Cell state · L2
FIB.barrier_secretory.remodeling
210 cells in the full atlas (not the displayed sample).
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Marker genes
ACTG1, CCDC80, CD151, CD248, CYTOR, DBN1, EMP3, HTRA3, IGFBP6, PRSS23, RAB32, RHOA, S100A10, SH3BGRL3, SMIM15, SPARC, TXNDC17, TYMP
Annotation genes
CCDC80, CD248, HTRA3, IGFBP6, PRSS23, SPARC
Annotation rationales
When barrier breaks, fibroblasts upshift protease (HTRA3/PRSS23) and matricellular modules (SPARC/CCDC80), plus activation markers (CD248). RHOA/ACTG1/DBN1 support traction for matrix re-weaving; IGFBP6 restrains proliferation signals.
Functional implications
Degrades and re-laces ECM to restore barrier mechanics; coordinates with endothelium for perivascular sealing; limits exuberant epithelial/stromal proliferation to avoid fibrotic stenosis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.