Cell state · L2
FIB.barrier_purinergic.stress_GF_binding
132 cells in the full atlas (not the displayed sample).
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Marker genes
ATF3, CCDC80, CEBPD, EFEMP1, FGF7, IER3, IGFBP5, IGFBP6, NBL1, NFKBIA, RPL7, RPLP0, RPSA, VIM
Annotation genes
ATF3, EFEMP1, FGF7, IGFBP5, IGFBP6, NFKBIA
Annotation rationales
Under epithelial stress, these fibroblasts flip on IEGs (ATF3/IER3/CEBPD) and deploy EFEMP1/CCDC80 to alter matrix pliability. IGFBP5/6 buffer IGF availability; FGF7 (KGF) directly stimulates epithelial proliferation and barrier restoration; NFKBIA tempers NF-κB signaling to avoid chronic inflammation.
Functional implications
Acts as a growth-factor “sponge” and delivery platform: sequesters and doses IGF/FGF to epithelium for orderly restitution while damping cytokine cascades. Preserves barrier function by preventing over-repair and fibrosis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.