Cell state · L2
FIB.adventitial.mito_secretory
721 cells in the full atlas (not the displayed sample).
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Marker genes
COX16, SYNJ2BP
Annotation genes
COX16, SYNJ2BP
Annotation rationales
COX16 supports complex IV assembly, while SYNJ2BP tethers mitochondria to ER, enhancing localized ATP/Ca²⁺ microdomains for secretion. In fibroblasts this underpins high ECM and cytokine output during activation without lineage conversion.
Functional implications
Powers bursts of secretory activity (collagens, proteases, cytokines) while maintaining mitochondrial fitness—enabling sustained remodeling near vessels during injury.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.