Cell state · L2
FIB.adventitial.mechano_chemo_sensing
2,963 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
FMO2, KCNMB2, NPHP3, SPRY2
Annotation genes
NPHP3, SPRY2
Annotation rationales
Primary-cilium component NPHP3 and RTK brake SPRY2 indicate a cell specialized to sample luminal/mechanical cues (flow, stretch) relayed from endothelium/smooth muscle. KCNMB2 tunes BK-channel responses and calcium oscillations that couple to integrin signaling.
Functional implications
Damps excessive growth-factor responses, calibrates mechano-transduction thresholds, and helps the adventitia adapt to pressure changes by adjusting focal adhesion dynamics and ECM deposition rates.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.