Cell state · L2
FIB.adventitial.complement_angiocrine
5,164 cells in the full atlas (not the displayed sample).
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Marker genes
ANG, APP, C1R, C3, C7, CFD, COL14A1, DCN, FBLN1, GSN, MMP2, PSAP, RNASE4, SERPINF1, SERPING1, SPARCL1
Annotation genes
C1R, C3, C7, CFD, MMP2, SERPING1, SPARCL1
Annotation rationales
Adventitial fibroblasts are key innate-immunity suppliers for vessel walls. Local production of complement (C1R/C3/C7/CFD) primes opsonization while SERPING1 brakes activation to avoid bystander damage. SPARCL1 and DCN sculpt the pericellular matrix and influence endothelial quiescence; SERPINF1 (PEDF) adds anti-angiogenic tone. MMP2 loosens perivascular collagen to accommodate remodeling and immune cell transit.
Functional implications
Serves as an “angiocrine-immune” hub: meters complement on the vessel exterior, suppresses exuberant sprouting, and shapes ECM porosity so leukocytes can access inflamed endothelium without compromising wall integrity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.