Cell state · L2
FIB.adventitial.baseline
4,286 cells in the full atlas (not the displayed sample).
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Marker genes
ABCA10, ABCA6, ABCA8, ABCA9, ARGLU1, BCL6, BMPER, DDX17, DIO3OS, ECHDC2, EPB41L2, FMO2, RSRP1, SPATA6, SRRM2, TNS2, ZRANB2, PDGFRA
Annotation genes
ABCA10, ABCA6, ABCA8, ABCA9, ARGLU1, BCL6, BMPER, DDX17, DIO3OS, ECHDC2, EPB41L2, FMO2, RSRP1, SPATA6, SRRM2, TNS2, ZRANB2, PDGFRA
Annotation rationales
Transcription/processing genes dominate, consistent with homeostatic ECM upkeep. Adventitial fibroblasts in steady state supply fibrillar collagens, SLRPs (decorin/biglycan), and microfibrillar components (MFAP5/PCOLCE2) to maintain the compliant sheath around vessels; PDGFRA signaling typically sustains this identity.
Functional implications
Sustains the adventitial scaffold and perivascular trophic milieu: continually repairs micro-damage in collagen/elastin, spaces fibers to preserve compliance, and provides paracrine support to vasa vasorum and resident immune cells.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.