Cell state · L2
FIB.adventitial.PI16_matrix
3,599 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACKR3, ADAMTS5, CD55, CLEC3B, CREB5, CYP4B1, DBN1, FBLN2, FBN1, FSTL1, GSN, IGFBP6, MFAP5, NHSL1, PCOLCE2, PI16, SCARA5, SLC4A4
Annotation genes
ADAMTS5, FBLN2, FBN1, MFAP5, PCOLCE2, PI16
Annotation rationales
PI16⁺ adventitial fibroblasts organize elastic microfibrils (FBN1/MFAP5) and mature collagen fibrils (PCOLCE2). ADAMTS5 trims versican, controlling pericellular hydration/chemokine retention. ACKR3 scavenges chemokines, shaping immune gradients; CD55 curbs complement.
Functional implications
Maintains an immune-tuned, elastic adventitial sleeve: clears chemokines to prevent chronic leukocyte trapping, preserves recoil via microfibril turnover, and balances proteoglycan levels to keep wall mechanics optimal.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.