Cell state · L2
EPI.renal_principal_cell.intercalated_like
682 cells in the full atlas (not the displayed sample).
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Marker genes
ATP6V1G3, C12orf75, CALCA, CDA, CLEC3B, DMRT2, IL18, LGALS3, LINC00671, LINC01187, PTGER3, RHCG, RNASEK, SLC26A7, TMEM213
Annotation genes
ATP6V1G3, LGALS3, RHCG, SLC26A7
Annotation rationales
Shows intercalated-cell shift: ATP6V1G3 (IC-selective V-ATPase), ammonia transporter RHCG, A-IC exchanger SLC26A7; LGALS3 marks activation. Expanded: a functional blend that increases acid excretion capacity when systemic acidosis or injury demands exceed IC supply.
Functional implications
Adopts acid–base transport features of A-type intercalated cells to excrete acid equivalents and buffer systemic pH during stress or remodeling. Provides flexible epithelial division of labor.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.