Cell state · L2
EPI.renal_principal_cell.inflammatory
499 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
BAG3, CXCL1, CYTOR, DDIT3, HSPE1, HSPH1, ICAM1, MAFF, NFKBIA, NFKBID, NR4A1, PHLDA2, PIM3, PMAIP1, PPP1R15A, RHOV, SERPINH1, TNF
Annotation genes
CXCL1, DDIT3, HSPH1, ICAM1, NFKBIA
Annotation rationales
NF-κB target signature (NFKBIA, CXCL1, ICAM1) plus ER-stress/UPR (DDIT3/CHOP, HSPs) → stressed/inflammatory PC state. Expanded: adhesion (ICAM1) promotes leukocyte engagement; proteostasis genes preserve channel folding to prevent water–salt transport collapse.
Functional implications
Coordinates cytokine signaling and ER-stress mitigation; maintains tubular transport while promoting leukocyte recruitment in inflamed kidney. Limits barrier failure and supports immune clearance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.