Cell state · L2
EPI.lung_multiciliated.stress
447 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ATF3, CCNL1, CD55, DUSP1, EFNA1, FOS, HES1, ID1, JUN, JUNB, KLF6, PPP1R15A, RHOB, SAT1, SERTAD1, TGIF1
Annotation genes
ATF3, DUSP1, FOS, HES1, JUN
Annotation rationales
IEG/MAPK and Notch-tone genes dominate, with little structural cilium content—consistent with activated ciliated cells experiencing cytokine/mechanical cues and modulating transcription/splicing (CCNL1) and MAPK feedback (DUSP1, ATF3). Expanded: EFNA1/RHOB indicate planar polarity and junctional tension adjustments that transiently tune ciliary beat frequency and barrier signaling under irritants.
Functional implications
Sensing & tuning state: rapid response to irritants/infection; adjust ciliary beat frequency and barrier signaling, coordinate with Notch to balance repair vs. function while keeping motile apparatus largely intact. Prevents epithelial fatigue and maintains clearance during acute inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.