Cell subtype · L1S
EPI.extrahepatic_cholangiocyte
448 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
KRT19, KRT7, CFTR, SLC4A2, MUC1, SOX9
Annotation genes
CFTR, SLC4A2, MUC1, KRT19
Annotation rationales
Extrahepatic cholangiocytes line the larger bile ducts outside the liver and combine a ductal keratin program with mucin and ion-transport machinery. Their phenotype is adapted to sustained exposure to concentrated bile.
Functional implications
They alkalinize and hydrate bile, provide a protective mucosal barrier and coordinate epithelial repair and inflammatory sensing in the extrahepatic ducts.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.