Cell state · L2
EPI.extrahepatic_cholangiocyte.barrier_interface
217 cells in the full atlas (not the displayed sample).
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Marker genes
ADGRG6, CLDN1, CLDN4, COL4A1, CREB5, CXCL1, CXCL3, CXCL8, FLNA, GABRP, GADD45A, ITGB8, LAMC2, LURAP1L, MACC1, NFKBIA, TPM1
Annotation genes
CLDN1, CLDN4, CXCL1, CXCL8, ITGB8, NFKBIA
Annotation rationales
Tight-junction claudins (1/4) plus basement membrane components (LAMC2/COL4A1) indicate a reinforced ductal seal; ITGB8 and FLNA strengthen ECM–cytoskeleton coupling under flow. CXCL1/3/8 establish neutrophil-recruiting gradients, while NFKBIA tempers NF-κB signaling to avoid duct damage.
Functional implications
Maintains a tight, shear-resistant biliary barrier while acting as an immune sentinel. Rapidly recruits neutrophils during ascending infection or obstruction, yet engages feedback brakes to protect duct integrity and prevent cholangitis-associated leak.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.