Cell state · L2
EPI.colonocyte.junction_remodeling
1,106 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARC, FOSL1, LAMA3, LIPH, LMO7, LPXN, NEDD4L, NT5DC3, PARD6B, PLAGL1, RELB, SGMS2, SNX9, SPAG9, TLCD1, VCL
Annotation genes
LAMA3, PARD6B, RELB, VCL
Annotation rationales
LAMA3 and VCL/LPXN require basement-membrane and focal-adhesion tuning; PARD6B regulates polarity complexes; SNX9/NEDD4L remodel endocytic trafficking of junctional proteins; RELB denotes noncanonical NF-κB–dependent barrier plasticity.
Functional implications
Adjusts tight junctions and apico-basal polarity to fine-tune permeability during mechanical strain, microbial signals, or cytokine exposure; prevents barrier failure by dynamically recycling claudins/occludins and reinforcing adhesive contacts.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.