Cell state · L2
EPI.colonocyte.ionocyte_BEST4
580 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADCY5, BEST4, CA4, CA7, CEACAM3, CEACAM6, FRMD1, GUCA2A, GUCA2B, HECAM2, LYPD8, MEIS1, NEURL1, NOTCH2, OTOP2, PCSK1N, PRKG1, PRKG2, SCIN, SPIB
Annotation genes
BEST4, CA4, CA7, GUCA2A, OTOP2, PRKG1
Annotation rationales
BEST4/OTOP2 define intestinal ionocytes; CA4/CA7 support rapid CO₂/HCO₃⁻ interconversion; GUCA2A/B activate cGMP signaling (PRKG1/2) to drive electrolyte secretion; LYPD8 contributes antimicrobial binding.
Functional implications
Senses luminal pH/electrolytes and drives cGMP-mediated bicarbonate/chloride secretion, modulating mucus pH and viscosity; contributes to antimicrobial defense and epithelial homeostasis in colon crypts.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.