Cell state · L2
EPI.colonocyte.goblet_interface
294 cells in the full atlas (not the displayed sample).
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Marker genes
ANO7, ANXA13, CACNA2D2, DLL1, ENTPD8, FAM174B, HES6, HID1, HPCAL1, KCNMA1, KLK1, L1TD1, LRRC26, PTPRN2, RAB26, RAP1GAP, RASA4, REP15, RETNLB, SPDEF, SPINK4, ST6GALNAC1, TFF3, TOX, TUBA1A, WFDC2
Annotation genes
RETNLB, SPDEF, SPINK4, TFF3
Annotation rationales
SPDEF, TFF3, SPINK4, and RETNLB reflect goblet-lineage influence; DLL1/HES6 signal Notch-mediated fate interface; trafficking enzymes (HID1/RAB26/REP15) enable secretory routing; ion channels adjust mucus hydration.
Functional implications
Mediates absorptive–secretory crosstalk, enhancing mucus layer quality while maintaining ion transport; supports barrier reinforcement during inflammation by biasing colonocytes toward secretory functions without fully converting to goblet cells.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.