Cell state · L2
EPI.colonocyte.crypt_progenitor
2,652 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ATF3, BAIAP2, CACNB2, CCDC88B, CDK6, CROCC, DNAJB1, DUSP8, EGR1, FAM53C, FOSB, GADD45G, GK5, HSPA1A, HSPA1B, HSPH1, ING1, ITGA6, JUN, KIF12, LFNG, LGR5, LINC01819, MIDN, MKNK2, PLK3, PTGDR, RASD1, RGMB, RNF43, SLC12A2, SMOC2, SOX4, TMX4, UTRN, ZBTB10
Annotation genes
ATF3, HSPA1A, JUN, LGR5, RNF43
Annotation rationales
LGR5 and RNF43 mark Wnt-responsive crypt stem/progenitors; IEG/HSP induction fits damage-associated proliferation; ITGA6 and SOX4 support adhesion and lineage priming; cell-cycle and cytoskeletal genes enable rapid expansion and migration.
Functional implications
Amplifies to replenish colonocytes after injury, migrating up the crypt–villus axis to restore barrier and transport; provides a transient proliferative surge under Wnt/EGFR cues to reseal mucosa and re-establish electrolyte absorption.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.