Cell state · L2
EPI.colonic_tuft.activated
254 cells in the full atlas (not the displayed sample).
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Marker genes
ATF3, BAIAP2, BRD2, EGR1, GADD45B, GLUL, KLF4, NEAT1, NFKBIZ, RHOB
Annotation genes
ATF3, EGR1, KLF4, NFKBIZ
Annotation rationales
IEGs (EGR1/ATF3) and NF-κB regulator NFKBIZ indicate rapid chemosensory activation; KLF4 supports epithelial stress adaptation and differentiation; GLUL boosts glutamine anaplerosis for metabolic rewiring; RHOB and BAIAP2 tune actin dynamics for apical tuft microvilli signaling.
Functional implications
Acts as a chemosensory alarm that translates luminal metabolites, helminth products, or bacterial signals into epithelial and ILC2/T helper responses; releases lipid mediators and cytokines while rapidly adjusting metabolism to sustain signaling and barrier defense.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.