Cell state · L2
EPI.alveolar_type_2.stress_response
2,853 cells in the full atlas (not the displayed sample).
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Marker genes
EGR1, HSPA1B, C2, EGLN3, MSMO1, PSAP, CRTAC1
Annotation genes
EGR1, HSPA1B, EGLN3, MSMO1, PSAP
Annotation rationales
EGR1 indicates rapid transcriptional activation under stress, while HSPA1B encodes a chaperone that preserves proteostasis. EGLN3 is a hypoxia sensor, MSMO1 supports sterol remodeling in surfactant membranes, and PSAP enhances lysosomal recycling. C2 contributes to complement-mediated immune signaling.
Functional implications
Protects alveoli during hypoxia and irritation by restoring proteostasis, remodeling surfactant lipid composition, and accelerating endo-lysosomal recycling. Provides immune cues through complement to alveolar macrophages, maintaining gas-exchange stability under stress.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.