Cell state · L2
EC.heart_remodeling.remodeling_stalk
1,393 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
B2M, CAV1, CLEC14A, CLU, FN1, HLA-B, ITM2B, MGP, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, RPS3, SPARCL1, TM4SF1, VIM
Annotation genes
CAV1, CLEC14A, FN1, MGP, SPARCL1, TM4SF1
Annotation rationales
CLEC14A/TM4SF1 are classical stalk-cell adhesion/migration molecules; SPARCL1/FN1 regulate ECM deposition and remodeling; MGP prevents vascular calcification; CAV1 modulates mechanotransduction and vesicular transport. Enrichment of mitochondrial genes highlights the energetic demand of sustained sprouting. This captures supporting stalk ECs in active remodeling.
Functional implications
Structural stabilizers of neovessels: maintain lumen integrity, deposit ECM, and prevent ectopic calcification. By coupling mitochondrial ATP supply with adhesive/ECM programs, they fuel the energetic and mechanical backbone of vessel remodeling in the heart, enabling long-term stabilization of sprouts.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.