Cell state · L2
EC.heart_remodeling.perivascular
2,028 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
C2CD2, CLEC11A, DACH2, FLVCR2, HES4, ISYNA1, LINC01099, NAV3, NCALD, SMTN
Annotation genes
DACH2, FLVCR2, HES4, SMTN
Annotation rationales
SMTN (smoothelin) is a smooth muscle–like contractile marker; DACH2/HES4 point to Notch-driven plasticity; FLVCR2 maintains EC identity. This suggests endothelial cells partially shifting toward a perivascular/mural-like state, enabling vessel stabilization and fibrovascular transition.
Functional implications
Endothelial-to-mesenchymal–leaning cells that provide structural support, perivascular stabilization, and fibrosis contribution during chronic cardiac stress. They integrate with mural cells to thicken vessel walls, contributing to vascular stiffening and maladaptive remodeling.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.