Cell state · L2
B.memory.migratory
2,890 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADK, ANXA2, ANXA4, BIN2, CAPZB, COCH, CPNE5, CRIP1, CRIP2, EBI3, FUT7, GCSAM, GRAMD1C, GSN, GSTK1, HIPK2, HOMER3, HOPX, ITGB1, LYPLAL1, PDE4D, PIK3R5, RNASEK, S100A10, TKT
Annotation genes
BIN2, FUT7, GCSAM, ITGB1, PIK3R5
Annotation rationales
BIN2/GCSAM (HGAL)/CAPZB/GSN/ANXA2 enrich for actin remodeling, immune-synapse stability, and high motility—features of cells that engage Tfh or APCs across changing microenvironments. FUT7 endows functional selectin ligands that facilitate high-endothelial venule transit; ITGB1 supports firm adhesion to VCAM-1–bearing stroma and tissue entry. PIK3R5 (PI3Kγ) tunes chemokine receptor sensitivity, while PDE4D sets cAMP rheostats to prevent desensitization during repeated chemokine encounters. Metabolic cofactors (TKT, GSTK1, LYPLAL1) support flexible energy routing during travel. Collectively this indicates a memory subset specialized for wide-area antigen surveillance.
Functional implications
Operates as a roving memory patrol that continuously scans lymph nodes, spleen, and inflamed tissues, ensuring early interception of antigen where it appears. Efficient HEV entry/egress and integrin-mediated tissue anchoring let these cells establish contacts with Tfh and dendritic cells on short notice, accelerating recall kinetics in peripheral sites. By distributing memory geographically, they extend protection to barrier organs and lesions that are distant from secondary lymphoid organs, promoting rapid local plasmablast formation and containment of infections.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.