Cell state · L2
B.memory.baseline
13,404 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AIM2, CD27, FCRL2, GPR183, LINC01781, S100A6, TNFRSF13B, VIM
Annotation genes
CD27, FCRL2, GPR183, TNFRSF13B
Annotation rationales
CD27/FCRL2 delineate antigen-experienced memory distinct from naïve pools and often associate with class-switch history. GPR183 (EBI2) orients cells along oxysterol gradients to interfollicular and medullary zones where antigen and T-cell help can be encountered efficiently without constant activation. TNFRSF13B (TACI) integrates BAFF/APRIL survival signals from stromal and myeloid cells, sustaining low-turnover, long-lived memory. AIM2/S100A6/VIM support cytoskeletal resilience and stress sensing compatible with longevity. This constellation defines the quiescent, energy-efficient memory core that preserves clonal breadth.
Functional implications
Serves as the durable archive of humoral immunity, maintaining diverse, high-value clones for years with minimal metabolic cost. Strategically positioned by EBI2, these cells can quickly sense antigen relayed from subcapsular macrophages or dendritic cells and shift into plasmablast or GC pathways on demand. TACI-dependent trophic support buffers them against attrition, securing vaccine durability and long-term protection. On re-challenge, they provide a rapid wave of antibody secretion while seeding new rounds of selection only when beneficial.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.