Cell state · L2
B.memory.activated
3,376 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BAG3, CXCR4, DNAJB1, DUSP1, FOS, GADD45B, HSPA1A, HSPA1B, HSPH1, JUN, RHOB
Annotation genes
CXCR4, DNAJB1, DUSP1, FOS, HSPA1A, JUN
Annotation rationales
The co-induction of FOS/JUN (AP-1) with DUSP1 (MAPK phosphatase) is a classic immediate-early response to antigen or bystander cytokines, coupling strong BCR/TLR signaling to built-in attenuation that prevents runaway activation. DNAJB1/HSPA1A/HSPH1 indicate a chaperone surge that safeguards nascent polypeptides and preserves BCR surface density and signaling fidelity under high protein-folding demand. GADD45B supports stress-adapted survival and NF-κB crosstalk; RHOB participates in endosomal trafficking and immune-synapse remodeling. CXCR4 biases homing to germinal center dark-zone–like and bone-marrow niches, positioning recently triggered memory for secondary selection or maintenance. Altogether this profile captures memory B cells that have just engaged antigen and rapidly re-establish proteostasis and positioning cues to balance effector readiness with longevity.
Functional implications
Acts as a swift recall effector that can (i) deliver rapid cytokine and costimulatory output, (ii) re-enter secondary GC reactions for further affinity maturation, or (iii) traffic to bone marrow survival niches. The proteostasis program allows these cells to withstand the acute surge in antibody and receptor turnover during recall, preserving viability and function. CXCR4-guided repositioning enables flexible routing between lymph-node zones and marrow stromal niches, supporting either renewed proliferation or long-term persistence. Functionally, they amplify early protection after re-exposure while preserving the option to refine the antibody repertoire.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.