Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90469293 · All tissues

GADD45GIP1 levels: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: GADD45GIP1 levels

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	chondrocyte	41.02	Significant	9.69e-06	1.19	Specific	548	1,069
2	monocyte	30.26	Significant	3.30e-49	1.26	Specific	2,176	3,871
3	platelet	29.31	Significant	—	1.67	Relevant	85	104
4	dendritic_cell	13.64	Significant	2.60e-03	1.11	Specific	496	724
5	skeletal_muscle_cell	12.59	Significant	2.08e-07	1.15	Specific	944	2,600
6	macrophage	8.06	Significant	2.40e-05	1.08	Other	813	1,732
7	haematopoietic_progenitor_cell	7.89	Significant	0.94	1.06	Relevant	262	502
8	adipocyte	5.07	Nominal	1.00	0.98	Other	33	111
9	granulosa_cell	3.82	Nominal	1.00	0.94	Other	293	670
10	mesothelial_cell	3.02	Nominal	1.00	0.93	Other	6	36
11	granulocyte	2.56	Nonsignificant	1.00	0.88	Other	5	6
12	endothelial_cell	1.90	Nonsignificant	1.00	0.79	Other	373	974
13	smooth_muscle_cell	1.69	Nonsignificant	1.00	0.79	Other	27	139
14	muscle_stem_cell	1.62	Nonsignificant	1.00	0.87	Other	7	27
15	natural_killer_cell	1.30	Nonsignificant	1.00	0.79	Other	1,204	2,052
16	adipose_stem_and_progenitor_cell	1.08	Nonsignificant	1.00	0.72	Other	327	954
17	pericyte	0.90	Nonsignificant	1.00	0.67	Other	128	517
18	hepatocyte	0.84	Nonsignificant	1.00	0.69	Other	1,515	3,822
19	cardiomyocyte	0.81	Nonsignificant	1.00	0.67	Other	533	2,045
20	epithelial_cell	0.76	Nonsignificant	1.00	0.68	Other	24	47
21	fibroblast	0.71	Nonsignificant	1.00	0.68	Other	184	826
22	melanocyte	0.57	Nonsignificant	1.00	0.62	Other	97	309
23	astrocyte	0.44	Nonsignificant	1.00	0.75	Other	256	1,203
24	oligodendrocyte_precursor_cell	0.35	Nonsignificant	1.00	0.62	Other	461	1,454
25	innate_lymphoid_cell_2	0.26	Nonsignificant	1.00	0.63	Other	3	8
26	microglia	0.19	Nonsignificant	1.00	0.55	Other	61	129
27	plasma_cell	0.12	Nonsignificant	1.00	0.52	Other	17	24
28	B_cell	0.11	Nonsignificant	1.00	0.56	Other	356	694
29	neuron	0.08	Nonsignificant	1.00	0.51	Other	330	1,328
30	T_cell	0.06	Nonsignificant	1.00	0.37	Other	470	959
31	schwann_cell	0.05	Nonsignificant	1.00	0.48	Other	10	57
32	induced_pluripotent_stem_cell	0.05	Nonsignificant	1.00	0.51	Other	0	0
33	thymocyte	3.39e-03	Nonsignificant	1.00	0.43	Other	168	512
34	oligodendrocyte	9.11e-04	Nonsignificant	1.00	0.56	Other	385	1,507

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	CHOND.chondrocyte	41.02	Significant	—	—	Specific	519	730
2	MONO.CD14	32.77	Significant	2.00e-50	3.84	Specific	2,294	4,139
3	PLAT.platelet	29.31	Significant	—	0.00	Relevant	38	53
4	DC.cDC2	17.88	Significant	1.97e-13	2.20	Specific	1,189	1,793
5	MONO.CD16	17.17	Significant	1.00	0.14	Specific	1,304	1,835
6	MAC.alveolar	16.55	Significant	2.11e-04	1.51	Specific	1,432	3,122
7	MAC.LAM	13.98	Significant	4.69e-10	1.52	Specific	914	2,064
8	SKM.type_2_fast	12.68	Significant	0.35	1.12	Specific	972	2,639
9	MAC.proliferating	12.47	Significant	0.34	1.21	Relevant	87	253
10	SKM.type_1_slow	12.47	Significant	0.35	1.29	Specific	923	2,478
11	EC.liver_sinusoidal	11.75	Significant	7.67e-21	2.02	Specific	1,083	1,925
12	EPI.thymic_cortical	11.49	Significant	8.66e-05	1.45	Specific	442	824
13	MAC.MDM	9.27	Significant	0.61	1.06	Relevant	623	986
14	EC.lymphatic	8.58	Significant	1.33e-19	2.00	Specific	630	998
15	HPC.haematopoietic_progenitor_cell	7.89	Significant	—	—	Relevant	211	370
16	FIB.transitioning	6.22	Significant	0.08	1.48	Other	172	497
17	DC.mig	5.88	Significant	—	0.00	Relevant	89	156
18	ADIPO.adipocyte	5.07	Nominal	—	—	Other	20	62
19	GRANU.neutrophil	3.85	Nominal	0.06	1.88	Other	1,235	2,649
20	GRNLSA.granulosa_cell	3.82	Nominal	—	—	Other	257	0
21	EPI.salivary_mucous_acinar	3.54	Nominal	2.85e-06	1.42	Other	639	1,189
22	MAC.resident_iron	3.35	Nominal	1.00	0.50	Other	16	21
23	EPI.alveolar_type_2	3.26	Nominal	2.85e-06	1.37	Other	813	1,853
24	DC.cDC1	3.03	Nominal	1.00	0.31	Other	55	112
25	MESO.mesothelial_cell	3.02	Nominal	—	—	Other	2	18
26	EPI.renal_proximal_tubule	2.99	Nonsignificant	0.01	1.35	Other	525	806
27	MAC.resident_repair	2.89	Nonsignificant	1.00	0.52	Other	796	1,426
28	EPI.pancreatic_ductal_mucinous	2.41	Nonsignificant	1.00	1.14	Other	219	430
29	MAC.microglia_like	2.15	Nonsignificant	1.00	0.49	Other	124	179
30	FIB.skin_tenogenic	2.12	Nonsignificant	—	1.59	Other	108	227
31	FIB.barrier_secretory	2.04	Nonsignificant	0.21	1.38	Other	81	228
32	HEP.acute_phase	1.98	Nonsignificant	1.74e-10	1.40	Other	1,441	3,641
33	GRANU.MAST	1.83	Nonsignificant	1.00	0.00	Other	5	6
34	EC.heart_remodeling	1.77	Nonsignificant	0.17	1.18	Other	569	1,594
35	SMC.smooth_muscle_cell	1.69	Nonsignificant	—	—	Other	20	101
36	FIB.reticular	1.64	Nonsignificant	0.24	1.23	Other	19	87
37	MUSC.muscle_stem_cell	1.62	Nonsignificant	—	—	Other	4	18
38	B.age_associated	1.54	Nonsignificant	0.27	1.13	Other	207	350
39	FIB.hepatic_stellate_cell	1.44	Nonsignificant	—	1.01	Other	64	252
40	NK.natural_killer_cell	1.30	Nonsignificant	—	—	Other	1,204	2,045
41	EC.capillary	1.28	Nonsignificant	1.00	0.69	Other	514	1,635
42	FIB.skin_papillary	1.22	Nonsignificant	—	0.79	Other	0	0
43	FIB.skin_sheath	1.18	Nonsignificant	0.62	1.08	Other	49	118
44	ASPC.adipose_stem_and_progenitor_cell	1.08	Nonsignificant	—	—	Other	324	930
45	FIB.interstitial	1.08	Nonsignificant	6.82e-05	1.32	Other	288	940
46	EPI.tracheal_basal	1.08	Nonsignificant	1.00	1.09	Other	398	1,120
47	EPI.skin_sebaceous_duct_luminal	1.05	Nonsignificant	1.00	1.04	Other	100	249
48	EC.venous	1.03	Nonsignificant	1.00	0.35	Other	516	1,387
49	EPI.ileal_goblet	1.03	Nonsignificant	1.00	1.06	Other	181	432
50	FIB.tracheal_subepithelial	1.02	Nonsignificant	—	0.59	Other	0	0
51	EC.arterial	1.01	Nonsignificant	1.00	0.51	Other	356	885
52	MAC.kupffer	0.97	Nonsignificant	1.00	0.35	Other	189	530
53	PERI.pericyte	0.90	Nonsignificant	—	—	Other	117	0
54	EPI.colonic_tuft	0.88	Nonsignificant	—	0.67	Other	7	24
55	B.germinal_center	0.85	Nonsignificant	0.50	1.12	Other	233	655
56	EPI.ectocervical_granular	0.84	Nonsignificant	—	0.61	Other	11	23
57	CM.cardiomyocyte	0.81	Nonsignificant	—	—	Other	524	2,032
58	FIB.neurolectin_mucosa	0.81	Nonsignificant	1.00	0.90	Other	133	394
59	EPI.salivary_serous_acinar	0.79	Nonsignificant	1.00	1.02	Other	233	531
60	HEP.canalicular_transport	0.73	Nonsignificant	1.00	0.82	Other	1,290	3,434
61	EPI.skin_keratinocyte_progenitor	0.73	Nonsignificant	—	0.64	Other	0	3
62	EPI.extrahepatic_cholangiocyte	0.68	Nonsignificant	—	0.61	Other	37	71
63	EPI.colonic_enteroendocrine	0.62	Nonsignificant	—	0.52	Other	1	1
64	FIB.lung_alveolar	0.62	Nonsignificant	—	0.29	Other	6	15
65	EPI.ileal_bile_transport	0.62	Nonsignificant	1.00	1.00	Other	61	93
66	MEL.melanocyte	0.57	Nonsignificant	—	—	Other	79	242
67	EPI.esophageal_suprabasal	0.54	Nonsignificant	1.00	0.87	Other	158	404
68	EPI.skin_follicular_keratinizing	0.54	Nonsignificant	1.00	0.86	Other	30	81
69	EPI.skin_hair_follicle_bulge	0.52	Nonsignificant	1.00	0.84	Other	51	178
70	T.CD8_Tem	0.50	Nonsignificant	1.65e-12	1.13	Other	1,083	1,857
71	DC.pDC	0.49	Nonsignificant	1.00	0.00	Other	496	1,028
72	HEP.pericentral_lipoprotein	0.49	Nonsignificant	—	0.28	Other	0	0
73	EPI.renal_thick_ascending_limb	0.47	Nonsignificant	1.00	0.82	Other	453	1,153
74	EPI.lung_club_secretory	0.45	Nonsignificant	1.00	1.18	Other	5	14
75	ASTRO.astrocyte	0.44	Nonsignificant	—	—	Other	228	1,111
76	NEU.EXC_SYT2	0.43	Nonsignificant	—	1.37	Other	40	77
77	FIB.perivascular_interface	0.42	Nonsignificant	1.00	0.82	Other	0	0
78	EPI.renal_intercalated_cell_type_A	0.39	Nonsignificant	1.00	0.72	Other	67	142
79	OPC.oligodendrocyte_precursor_cell	0.35	Nonsignificant	—	—	Other	413	1,269
80	EPI.skin_keratinocyte_basal	0.34	Nonsignificant	—	0.33	Other	13	26
81	EPI.salivary_myoepithelial	0.34	Nonsignificant	1.00	0.83	Other	191	714
82	NEU.INH_LAMP5	0.34	Nonsignificant	0.34	1.15	Other	263	532
83	FIB.barrier_purinergic	0.33	Nonsignificant	—	0.00	Other	1	3
84	EPI.esophageal_basal	0.33	Nonsignificant	1.00	0.76	Other	4	10
85	FIB.skin_neurosecretory	0.32	Nonsignificant	—	0.01	Other	0	0
86	EPI.endocervical_secretory	0.31	Nonsignificant	—	0.20	Other	0	0
87	FIB.suburothelial	0.28	Nonsignificant	1.00	0.72	Other	122	432
88	ILC2.innate_lymphoid_cell_2	0.26	Nonsignificant	—	—	Other	2	0
89	EPI.renal_principal_cell	0.24	Nonsignificant	1.00	0.74	Other	207	403
90	NEU.EXC_CT	0.24	Nonsignificant	0.10	1.23	Other	362	384
91	EPI.tracheal_suprabasal	0.23	Nonsignificant	1.00	0.68	Other	29	56
92	MAC.resident_cardiac	0.22	Nonsignificant	1.00	0.00	Other	485	1,074
93	T.CD4_Th2	0.22	Nonsignificant	—	0.90	Other	1	2
94	EPI.intrahepatic_cholangiocyte_defense	0.21	Nonsignificant	—	0.04	Other	8	13
95	MG.microglia	0.19	Nonsignificant	—	—	Other	49	0
96	EPI.salivary_intercalated_defense	0.19	Nonsignificant	1.00	0.75	Other	81	161
97	PC.IgG_systemic	0.18	Nonsignificant	0.45	1.14	Other	41	60
98	EPI.ileal_enterocyte_absorptive	0.16	Nonsignificant	1.00	0.68	Other	118	338
99	EPI.tracheal_submucosal_gland	0.15	Nonsignificant	—	0.04	Other	0	0
100	EPI.skin_sweat_duct_keratinocyte	0.15	Nonsignificant	1.00	0.70	Other	146	301
101	NEU.INH_PVALB	0.14	Nonsignificant	0.48	1.06	Other	193	183
102	HEP.periportal_metabolic	0.14	Nonsignificant	1.00	0.24	Other	1,750	4,427
103	NEU.EXC_NTNG1	0.13	Nonsignificant	—	0.91	Other	0	0
104	FIB.adventitial	0.13	Nonsignificant	1.00	0.00	Other	268	1,447
105	PC.IgA_muocsal	0.11	Nonsignificant	0.99	0.68	Other	18	31
106	B.naive	0.08	Nonsignificant	0.81	0.99	Other	307	595
107	EPI.pancreatic_islet	0.08	Nonsignificant	1.00	0.82	Other	52	132
108	T.CD4_transitional	0.08	Nonsignificant	1.00	0.96	Other	48	110
109	EPI.renal_distal_tubule	0.07	Nonsignificant	1.00	0.63	Other	133	361
110	EPI.skin_keratinocyte_proliferating	0.07	Nonsignificant	1.00	0.66	Other	47	76
111	T.CD4_Tfh	0.07	Nonsignificant	1.00	0.94	Other	47	45
112	EPI.hepatic_ductular_cholangiocyte	0.06	Nonsignificant	1.00	0.59	Other	83	243
113	EPI.ileal_enterocyte_crypt	0.06	Nonsignificant	1.00	0.61	Other	67	113
114	SCHWN.schwann_cell	0.05	Nonsignificant	—	—	Other	7	33
115	IPSC.induced_pluripotent_stem_cell	0.05	Nonsignificant	—	—	Other	0	0
116	EPI.skin_hair_follicle_companion	0.05	Nonsignificant	—	0.00	Other	8	12
117	T.CD8_Trm	0.05	Nonsignificant	1.00	0.95	Other	211	346
118	EPI.renal_immature_ureteric_bud	0.04	Nonsignificant	1.00	0.56	Other	217	569
119	T.CD4_Trm	0.04	Nonsignificant	1.00	0.93	Other	176	363
120	EPI.salivary_duct_excretory	0.04	Nonsignificant	1.00	0.63	Other	85	180
121	T.CD8_transitional	0.04	Nonsignificant	1.00	0.95	Other	497	932
122	EPI.renal_intercalated_cell_type_B	0.03	Nonsignificant	—	0.00	Other	6	7
123	B.memory	0.03	Nonsignificant	1.00	0.85	Other	442	882
124	T.CD4_cytotoxic	0.03	Nonsignificant	1.00	0.91	Other	855	1,493
125	T.CD4_Treg	0.03	Nonsignificant	1.00	0.97	Other	244	511
126	EPI.pancreatic_ductal_bicarbonate	0.02	Nonsignificant	1.00	0.62	Other	131	548
127	EPI.thymic_medullary	0.02	Nonsignificant	1.00	0.56	Other	26	133
128	T.gamma_delta	0.02	Nonsignificant	1.00	0.94	Other	588	1,078
129	NEU.EXC_IT	0.02	Nonsignificant	1.00	0.59	Other	411	192
130	T.CD4_Th17	0.01	Nonsignificant	1.00	0.91	Other	421	794
131	EPI.skin_appendage_keratinocyte	0.01	Nonsignificant	1.00	0.46	Other	87	222
132	T.CD4_Tcm	8.09e-03	Nonsignificant	1.00	0.92	Other	494	988
133	T.CD4_naive	7.98e-03	Nonsignificant	1.00	1.00	Other	399	866
134	T.CD4_Tem	6.06e-03	Nonsignificant	1.00	0.85	Other	365	697
135	NEU.INH_VIP	5.64e-03	Nonsignificant	1.00	0.77	Other	241	366
136	EPI.gastric_foveolar	5.53e-03	Nonsignificant	—	0.00	Other	0	0
137	EPI.pancreatic_acinar	4.77e-03	Nonsignificant	1.00	0.52	Other	429	1,475
138	EPI.intrahepatic_cholangiocyte_transport	3.40e-03	Nonsignificant	—	0.00	Other	12	42
139	THYMO.thymocyte	3.39e-03	Nonsignificant	—	—	Other	163	495
140	EPI.skin_interfollicular_spinous	3.05e-03	Nonsignificant	1.00	0.32	Other	260	563
141	EPI.pancreatic_ductal_perivascular	2.47e-03	Nonsignificant	1.00	0.46	Other	4	30
142	EPI.salivary_duct_ion_transport	2.30e-03	Nonsignificant	1.00	0.36	Other	5	11
143	EPI.cervical_suprabasal	2.29e-03	Nonsignificant	—	0.00	Other	14	50
144	EPI.colonocyte	1.19e-03	Nonsignificant	1.00	0.28	Other	294	815
145	OLG.oligodendrocyte	9.11e-04	Nonsignificant	—	—	Other	384	1,397
146	T.CD8_naive	7.64e-04	Nonsignificant	1.00	0.80	Other	317	708
147	EPI.alveolar_type_1	5.74e-04	Nonsignificant	1.00	0.24	Other	26	101
148	EPI.lung_multiciliated	2.60e-04	Nonsignificant	1.00	0.23	Other	16	49
149	T.CD8_Tcm	1.94e-04	Nonsignificant	1.00	0.74	Other	460	926
150	T.MAIT	1.88e-04	Nonsignificant	1.00	0.79	Other	469	855
151	EPI.pancreatic_ductal_progenitor	3.50e-05	Nonsignificant	1.00	0.12	Other	234	873
152	EPI.bile_duct_cholangiocyte	3.26e-05	Nonsignificant	1.00	0.13	Other	37	60

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	CHOND.articular_collagen	48.10	Significant	0.16	1.52	—	551	266
2	MONO.CD14.platelet_bound	46.81	Significant	3.74e-06	2.67	—	964	176
3	PLAT.megakaryocytic	44.14	Significant	—	0.97	—	0	0
4	CHOND.activated_fibro_like	43.99	Significant	0.16	1.41	—	531	188
5	MONO.CD14.remodeling	36.77	Significant	3.74e-06	2.06	—	2,373	295
6	CHOND.remodeling	34.66	Significant	—	0.00	—	5	0
7	MONO.CD14.baseline	32.40	Significant	1.00	0.80	—	2,268	76
8	MONO.CD14.APC_like	30.23	Significant	1.00	0.50	Specific	1,686	2,493
9	DC.cDC2.monocyte_like	30.20	Significant	2.72e-03	2.03	—	1,285	791
10	MONO.CD14.cord_tolerance	28.63	Significant	0.07	1.68	—	864	753
11	MONO.CD16.platelet_bound	28.10	Significant	0.02	1.98	Specific	372	508
12	DC.cDC2.migratory	25.83	Significant	0.12	1.53	—	185	39
13	CHOND.pro_inflammatory	23.96	Significant	1.00	0.00	Relevant	181	351
14	MONO.CD16.inflammatory	21.07	Significant	8.31e-05	2.24	—	1,640	168
15	DC.cDC2.proliferative	20.90	Significant	—	0.00	Relevant	39	71
16	PLAT.adhesion	20.68	Significant	—	0.00	Relevant	0	0
17	MAC.LAM.lipid_phagocytosis	20.36	Significant	4.92e-03	1.93	—	369	328
18	MAC.LAM.perivascular_angiocrine	19.17	Significant	—	0.73	—	53	138
19	CHOND.angiogenic	18.92	Significant	—	0.00	Relevant	0	0
20	MAC.LAM.antimicrobial	18.71	Significant	0.03	1.66	—	389	93
21	MAC.alveolar.capillary_interacting	18.62	Significant	0.08	2.10	Relevant	113	181
22	MAC.proliferating.stress	18.55	Significant	—	0.72	Relevant	87	136
23	MONO.CD14.repair_M2_like	18.36	Significant	1.00	0.03	Relevant	550	1,495
24	MAC.alveolar.biosynthetic_sterol_heme	17.20	Significant	0.51	1.32	—	347	40
25	HPC.MPP_activated	16.77	Significant	—	1.21	—	0	0
26	MAC.alveolar.scavenging_endocytic	16.45	Significant	—	0.00	Relevant	140	283
27	MAC.alveolar.lipid_autophagy	16.25	Significant	—	0.00	Relevant	35	44
28	MAC.alveolar.inflammatory	16.07	Significant	0.82	0.64	Relevant	208	312
29	ADIPO.inflammatory	15.23	Significant	—	1.59	Relevant	0	0
30	MAC.alveolar.stress_metabolic	15.22	Significant	0.82	0.54	Relevant	116	148
31	MONO.CD16.hepatic_mac_like	15.12	Significant	0.21	1.42	—	803	117
32	MONO.CD16.patrolling	15.00	Significant	0.80	0.85	—	797	216
33	SKM.type_1_slow.oxidative	14.91	Significant	2.90e-06	3.17	—	802	251
34	DC.cDC2.adhesion_signaling	14.74	Significant	1.00	0.49	—	35	9
35	EC.liver_sinusoidal.stress	14.57	Significant	—	0.85	—	413	158
36	EC.liver_sinusoidal.inflammatory	14.31	Significant	—	0.98	—	223	154
37	MAC.LAM.anti_inflammatory	14.18	Significant	1.00	0.90	Relevant	86	132
38	EPI.thymic_cortical.Notch_interface	13.93	Significant	—	0.95	Relevant	82	137
39	MONO.CD16.baseline	13.58	Significant	0.80	0.69	—	50	1
40	EC.liver_sinusoidal.remodeling_lipotoxicity	13.40	Significant	—	0.15	—	90	58
41	SKM.type_2_fast.glycolytic_IIx_IIb	12.85	Significant	0.53	0.95	Relevant	565	1,482
42	DC.cDC2.tolerogenic_regulatory	12.84	Significant	1.00	0.50	—	44	4
43	SKM.type_2_fast.oxidative_IIa	12.59	Significant	0.37	1.36	—	946	56
44	EPI.thymic_cortical.baseline	12.34	Significant	0.57	0.86	Relevant	185	386
45	DC.cDC2.pro_inflammatory	12.25	Significant	1.00	0.33	—	3	5
46	EC.liver_sinusoidal.prostanoid	12.22	Significant	—	0.00	Relevant	11	64
47	SKM.type_1_slow.contractile	11.96	Significant	1.00	0.79	—	596	8
48	MAC.LAM.inflammatory_APC	11.87	Significant	1.00	0.27	—	872	165
49	FIB.transitioning.ISG_primed_interface	11.45	Significant	—	0.64	Relevant	17	80
50	DC.cDC2.antiviral	11.36	Significant	1.00	0.08	—	100	37
51	EC.liver_sinusoidal.hypoxia_metabolic	10.36	Significant	0.90	0.70	—	183	107
52	MAC.MDM.LAM_like	10.33	Significant	0.41	1.28	Relevant	12	14
53	EC.lymphatic.scavenger	10.27	Significant	0.05	2.10	Specific	203	257
54	SKM.type_1_slow.glycolytic	9.86	Significant	1.00	0.00	Relevant	362	647
55	MAC.MDM.inflammatory_phagocytic	9.82	Significant	0.41	1.17	—	199	52
56	MAC.MDM.APC_dendritic	9.82	Significant	0.41	1.22	—	48	15
57	MAC.proliferating.DNA_replication	9.60	Significant	0.95	0.31	Relevant	3	6
58	EC.liver_sinusoidal.secretory_lipoprotein	9.43	Significant	0.90	0.42	—	120	70
59	HPC.GMP_inflammatory	9.38	Significant	0.50	1.27	—	20	10
60	MAC.resident_repair.lipid_phagocytic	8.86	Significant	0.01	1.95	Specific	228	604
61	MONO.CD14.inflammatory	8.77	Significant	1.00	7.58e-03	—	92	134
62	EC.lymphatic.tip_migratory	8.62	Significant	0.76	0.80	Relevant	23	37
63	MAC.LAM.lipid_opsonization	8.30	Significant	1.00	0.14	—	45	14
64	FIB.transitioning.motility_remodelling	8.27	Significant	—	0.00	Relevant	0	0
65	EC.lymphatic.baseline	8.21	Significant	0.65	1.19	Relevant	38	72
66	MAC.MDM.complement_resolving	7.93	Significant	0.86	0.63	Relevant	440	860
67	EPI.thymic_cortical.secretory_remodeling	7.78	Significant	—	0.00	Other	4	1
68	EC.lymphatic.activated	7.77	Significant	0.76	0.67	Relevant	47	73
69	HPC.MEP	7.57	Significant	0.50	1.13	Relevant	599	1,195
70	HPC.MPP_IEG	7.20	Significant	0.50	1.09	—	45	46
71	HPC.LMPP	7.15	Significant	0.50	1.01	—	65	31
72	GRNLSA.secretory_remodeling	6.40	Significant	0.04	1.70	Specific	90	25
73	ADIPO.immature	6.21	Significant	—	0.22	Other	24	40
74	DC.cDC1.homeostatic_inhibitory	6.10	Significant	—	1.21	Relevant	0	0
75	DC.mig.baseline	5.88	Significant	—	0.00	—	1	0
76	GRANU.neutrophil.tissue_patrolling	5.73	Significant	—	1.28	Relevant	0	0
77	DC.cDC2.lipid_metabolic	5.63	Significant	—	0.00	Other	0	0
78	MAC.resident_iron.heme_catabolism	5.22	Nominal	0.44	1.20	Other	30	51
79	HPC.CLP_B_primed	4.94	Nominal	—	0.00	Other	0	0
80	ASPC.remodeling	4.87	Nominal	4.37e-18	2.42	Other	106	354
81	GRNLSA.proliferative_migratory	4.81	Nominal	0.04	1.69	Other	248	292
82	HEP.acute_phase.inflammatory	4.59	Nominal	6.94e-08	2.28	Other	382	649
83	EC.lymphatic.valve	4.57	Nominal	—	0.00	Other	0	0
84	GRNLSA.chemokine_mechanosensory	4.55	Nominal	0.76	1.06	Other	1	0
85	HPC.GMP_granulocytic	4.53	Nominal	—	0.00	Other	3	3
86	MAC.resident_iron.redox_metabolic	4.53	Nominal	0.34	1.41	Other	4	4
87	EPI.alveolar_type_2.stress_response	4.20	Nominal	1.88e-04	2.27	Other	675	1,562
88	GRANU.neutrophil.antiviral_endotoxin	4.18	Nominal	—	0.26	Other	0	0
89	GRNLSA.p53_damage	4.02	Nominal	—	0.14	Other	13	10
90	MESO.antiviral	3.57	Nominal	—	0.41	Other	3	8
91	MAC.resident_repair.antigen_presenting	3.57	Nominal	0.03	1.66	Other	244	113
92	EC.heart_remodeling.remodeling_secretory	3.55	Nominal	2.18e-05	1.83	Other	605	1,341
93	EPI.salivary_mucous_acinar.baseline	3.54	Nominal	—	—	Other	394	683
94	EPI.alveolar_type_2.baseline_surfactant	3.53	Nominal	0.79	0.97	Other	64	9
95	MAC.microglia_like.phagocytic_redox	3.49	Nominal	—	1.21	Other	0	0
96	GRNLSA.cholesterol_mevalonate	3.38	Nominal	0.76	1.00	Other	9	4
97	MESO.baseline	3.35	Nominal	0.39	1.15	Other	0	6
98	EPI.renal_proximal_tubule.detox_antioxidant	3.24	Nominal	1.66e-03	3.00	Other	394	77
99	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	3.09	Nominal	0.02	1.87	Other	449	1,034
100	MESO.secretory_structural	3.01	Nominal	—	0.19	Other	0	0
101	MAC.resident_iron.APC_iron_sensing	3.01	Nominal	0.60	0.93	Other	211	114
102	ASPC.adipocyte_capillary_interface	2.99	Nonsignificant	4.21e-03	1.86	Other	21	54
103	MESO.activated_stress	2.88	Nonsignificant	—	0.00	Other	0	0
104	DC.cDC1.activated	2.86	Nonsignificant	—	0.00	Other	0	0
105	ADIPO.thermogenic	2.85	Nonsignificant	—	0.15	Other	0	0
106	NK.cytokine_lung_immediate_early	2.77	Nonsignificant	3.55e-05	2.34	Other	424	274
107	EPI.ectocervical_granular.inflammatory	2.69	Nonsignificant	—	1.15	Other	0	0
108	EPI.renal_proximal_tubule.onecarbon_peroxisome	2.65	Nonsignificant	1.00	0.00	Other	58	89
109	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.62	Nonsignificant	—	0.10	Other	0	0
110	FIB.transitioning.secretory_procollagen	2.62	Nonsignificant	—	0.00	Other	0	0
111	FIB.reticular.stress_metallothionein	2.55	Nonsignificant	—	1.00	Other	3	32
112	EC.capillary.angiogenic_tip	2.49	Nonsignificant	9.07e-04	2.12	Other	186	218
113	MAC.microglia_like.inflammatory_chemokine	2.46	Nonsignificant	—	0.00	Other	20	32
114	DC.cDC1.cross_presenting	2.43	Nonsignificant	—	0.00	Other	0	0
115	MAC.resident_repair.stress_iron	2.38	Nonsignificant	0.45	1.27	Other	48	97
116	EC.capillary.activated	2.33	Nonsignificant	9.55e-03	2.04	Other	2	5
117	ASPC.proliferative	2.26	Nonsignificant	4.42e-03	1.91	Other	33	85
118	GRNLSA.EMT_insulin_signaling	2.26	Nonsignificant	0.99	0.52	Other	47	84
119	SMC.contractile	2.23	Nonsignificant	0.13	1.41	Other	80	588
120	GRNLSA.lipid_hypoxia	2.22	Nonsignificant	0.99	0.23	Other	28	0
121	EPI.lung_club_secretory.inflammatory	2.19	Nonsignificant	—	1.47	Other	0	0
122	MAC.resident_repair.chemokine_angiocrine	2.17	Nonsignificant	1.00	0.56	Other	87	138
123	MAC.resident_iron.heme_recycling	2.13	Nonsignificant	—	0.00	Other	30	37
124	FIB.skin_tenogenic.baseline	2.12	Nonsignificant	—	0.00	Other	0	2
125	B.age_associated.activated	2.10	Nonsignificant	—	0.64	Other	18	22
126	ASTRO.A1_reactive	2.10	Nonsignificant	0.07	1.16	Other	433	394
127	FIB.barrier_secretory.remodeling	2.09	Nonsignificant	—	0.00	Other	0	0
128	GRNLSA.angiocrine_mechanosensory	2.07	Nonsignificant	—	0.00	Other	0	0
129	EPI.ectocervical_granular.secretory_apocrine	2.07	Nonsignificant	—	0.32	Other	0	0
130	EC.venous.quiescent_homeostatic	2.06	Nonsignificant	2.78e-04	1.88	Other	456	360
131	HEP.acute_phase.baseline	2.00	Nonsignificant	0.76	1.11	Other	946	19
132	FIB.barrier_secretory.homeostasis	1.99	Nonsignificant	—	0.00	Other	0	0
133	GRANU.MAST.resting_granule	1.99	Nonsignificant	—	0.22	Other	0	0
134	DC.cDC1.proliferative	1.97	Nonsignificant	—	0.00	Other	0	0
135	FIB.transitioning.matrix_stress	1.96	Nonsignificant	—	0.00	Other	47	138
136	EC.venous.remodeling_stalk	1.95	Nonsignificant	4.52e-04	1.92	Other	559	566
137	B.germinal_center.LZ_survival	1.94	Nonsignificant	—	1.47	Other	0	0
138	EC.arterial.angiogenic_tip	1.93	Nonsignificant	—	1.16	Other	30	37
139	EC.arterial.inflammatory	1.91	Nonsignificant	0.19	1.40	Other	63	50
140	GRANU.neutrophil.primed_degranulation	1.90	Nonsignificant	—	0.00	Other	0	0
141	ASPC.inflammatory	1.90	Nonsignificant	0.13	1.45	Other	21	61
142	CM.mechano_activated	1.89	Nonsignificant	7.29e-07	2.10	Other	205	134
143	SMC.activated	1.89	Nonsignificant	0.11	1.55	Other	2	5
144	FIB.reticular.ECM_builder	1.88	Nonsignificant	—	0.39	Other	0	0
145	GRANU.MAST.activated_repair	1.87	Nonsignificant	—	0.08	Other	0	1
146	MESO.activated_migratory	1.87	Nonsignificant	—	0.00	Other	0	0
147	HEP.acute_phase.stress_secretory	1.87	Nonsignificant	0.84	0.96	Other	26	3
148	EPI.alveolar_type_2.injury_primed	1.85	Nonsignificant	1.00	0.00	Other	434	245
149	MUSC.early_activation	1.83	Nonsignificant	0.65	1.51	Other	4	32
150	FIB.reticular.immune_interface	1.83	Nonsignificant	—	0.29	Other	1	6
151	HEP.acute_phase.complement_antiviral	1.78	Nonsignificant	0.84	0.87	Other	377	751
152	GRNLSA.stress_metabolic	1.75	Nonsignificant	—	0.00	Other	1	2
153	CM.inflammatory	1.74	Nonsignificant	—	1.44	Other	0	0
154	MAC.kupffer.monocyte_like	1.69	Nonsignificant	—	0.53	Other	0	0
155	MAC.resident_repair.ECM_stromal_crosstalk	1.69	Nonsignificant	1.00	0.18	Other	95	158
156	FIB.interstitial.stress_secretory	1.65	Nonsignificant	0.35	1.33	Other	92	56
157	MUSC.quiescent_reservoir	1.63	Nonsignificant	0.82	0.90	Other	2	8
158	MUSC.baseline	1.63	Nonsignificant	0.82	0.82	Other	0	0
159	MAC.kupffer.tolerogenic	1.62	Nonsignificant	—	0.80	Other	45	49
160	FIB.hepatic_stellate_cell.inflammatory	1.61	Nonsignificant	—	1.15	Other	0	0
161	EC.heart_remodeling.perivascular	1.59	Nonsignificant	0.95	0.82	Other	124	408
162	EC.capillary.stress	1.57	Nonsignificant	0.03	1.62	Other	44	36
163	EC.venous.activated	1.54	Nonsignificant	6.99e-03	1.54	Other	247	752
164	NK.cytokine_tissue_activation	1.54	Nonsignificant	0.91	1.06	Other	267	450
165	NK.adaptive_adipose_stress	1.53	Nonsignificant	0.91	1.05	Other	374	39
166	PERI.inflammatory	1.53	Nonsignificant	7.36e-06	2.00	Other	40	77
167	NK.cytokine_axis_baseline	1.50	Nonsignificant	0.06	1.38	Other	1,172	116
168	FIB.hepatic_stellate_cell.contractile	1.49	Nonsignificant	—	0.32	Other	0	0
169	NK.cytokine_quiescent	1.48	Nonsignificant	0.34	1.37	Other	623	1,062
170	EC.arterial.arteriole_gas_exchange	1.46	Nonsignificant	0.19	1.31	Other	238	131
171	NK.cytokine_vascular_patrolling	1.44	Nonsignificant	0.48	1.23	Other	863	94
172	EC.heart_remodeling.remodeling_stalk	1.42	Nonsignificant	0.95	0.89	Other	33	111
173	NK.cytokine_biosynthetic_primed	1.42	Nonsignificant	0.91	1.10	Other	360	21
174	GRANU.MAST.activated_acute	1.41	Nonsignificant	—	0.00	Other	0	0
175	FIB.skin_sheath.neuro_vascular_interface	1.40	Nonsignificant	—	0.80	Other	0	0
176	MUSC.activated_migratory	1.39	Nonsignificant	0.83	0.50	Other	6	7
177	NK.adaptive_HLAE_tuned	1.38	Nonsignificant	0.91	0.94	Other	1,124	189
178	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.37	Nonsignificant	0.01	2.31	Other	2	9
179	EC.arterial.ion_pump	1.37	Nonsignificant	0.62	1.11	Other	3	2
180	NK.adaptive_biosynthetic_primed	1.35	Nonsignificant	0.91	0.85	Other	244	405
181	NK.adaptive_axis_baseline	1.35	Nonsignificant	0.91	0.94	Other	1,008	153
182	FIB.interstitial.lipid_matrix	1.35	Nonsignificant	0.04	1.58	Other	258	191
183	NK.cytokine_repair_primed	1.34	Nonsignificant	0.91	1.02	Other	266	11
184	NK.adaptive_classII_inhibitory	1.34	Nonsignificant	0.91	0.94	Other	880	154
185	HEP.acute_phase.proliferative	1.33	Nonsignificant	—	0.00	Other	4	6
186	FIB.hepatic_stellate_cell.fibrogenic	1.32	Nonsignificant	—	0.00	Other	0	0
187	EC.capillary.inflammatory	1.30	Nonsignificant	1.00	0.91	Other	27	51
188	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.28	Nonsignificant	—	0.00	Other	0	0
189	B.age_associated.migratory	1.27	Nonsignificant	0.89	0.40	Other	2	2
190	EC.heart_remodeling.capillary_metabolic	1.23	Nonsignificant	0.89	1.19	Other	54	414
191	FIB.skin_papillary.baseline	1.22	Nonsignificant	—	0.00	Other	0	0
192	FIB.interstitial.mesenchymal_APC	1.21	Nonsignificant	0.12	1.46	Other	81	33
193	MAC.kupffer.metabolic	1.21	Nonsignificant	—	0.58	Other	25	36
194	EC.capillary.postcap_venule	1.20	Nonsignificant	1.00	0.85	Other	355	261
195	EC.arterial.arteriole_interface	1.18	Nonsignificant	0.56	1.13	Other	31	12
196	HEP.canalicular_transport.inflammatory	1.18	Nonsignificant	3.42e-05	1.45	Other	1,335	194
197	EPI.ileal_goblet.baseline	1.18	Nonsignificant	0.20	1.72	Other	16	2
198	FIB.interstitial.immune_interact	1.17	Nonsignificant	0.73	1.00	Other	12	1
199	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.16	Nonsignificant	—	0.00	Other	0	0
200	ASPC.activated	1.16	Nonsignificant	0.15	1.27	Other	164	162
201	EC.capillary.angiocrine	1.16	Nonsignificant	1.00	0.67	Other	250	630
202	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.16	Nonsignificant	—	0.00	Other	0	0
203	FIB.skin_sheath.stress_chaperone	1.15	Nonsignificant	—	0.00	Other	0	0
204	EPI.tracheal_basal.homeostatic_progenitor	1.15	Nonsignificant	0.07	1.87	Other	285	74
205	ASPC.stem_like_progenitor	1.13	Nonsignificant	0.07	1.48	Other	300	842
206	B.age_associated.naive_transitional	1.12	Nonsignificant	—	0.00	Other	0	0
207	FIB.reticular.stromal_niche	1.11	Nonsignificant	1.00	0.00	Other	0	0
208	ADIPO.hypoxia_remodelling	1.11	Nonsignificant	—	0.00	Other	29	105
209	EC.arterial.mito_contact	1.09	Nonsignificant	0.56	1.21	Other	14	5
210	DC.cDC1.baseline	1.09	Nonsignificant	—	0.00	Other	0	0
211	EC.capillary.migratory	1.08	Nonsignificant	1.00	0.71	Other	181	509
212	ASPC.preadipocyte_lipid_primed	1.08	Nonsignificant	0.25	1.13	Other	331	129
213	HEP.acute_phase.complement_metabolic	1.08	Nonsignificant	1.00	0.03	Other	1,423	3,464
214	B.germinal_center.LZ_memory_precursor	1.06	Nonsignificant	—	0.79	Other	0	0
215	CM.sarcomere_actin_interface	1.06	Nonsignificant	0.09	1.36	Other	450	78
216	FIB.adventitial.activated_remodelling	1.05	Nonsignificant	—	1.84	Other	141	319
217	EPI.ileal_goblet.stress_metallothionein	1.05	Nonsignificant	—	0.00	Other	4	11
218	EC.capillary.baseline	1.03	Nonsignificant	1.00	0.33	Other	246	560
219	FIB.tracheal_subepithelial.baseline	1.02	Nonsignificant	—	0.00	Other	0	0
220	EPI.colonic_tuft.homeostatic	1.02	Nonsignificant	—	0.42	Other	0	0
221	FIB.neurolectin_mucosa.nerve_interface	1.02	Nonsignificant	—	0.64	Other	4	0
222	CM.anti_inflammatory	1.01	Nonsignificant	0.05	1.41	Other	424	1,503
223	HEP.canalicular_transport.sterol_lipid_biosynthesis	1.01	Nonsignificant	—	0.39	Other	10	20
224	SMC.metabolic	1.01	Nonsignificant	1.00	0.00	Other	14	40
225	PERI.angiocrine	1.00	Nonsignificant	0.22	1.24	Other	93	102
226	EPI.tracheal_basal.activated_stress	0.98	Nonsignificant	0.66	0.75	Other	32	0
227	DC.pDC.poised_migratory	0.98	Nonsignificant	0.12	1.48	Other	54	95
228	EC.heart_remodeling.activated_acute	0.98	Nonsignificant	0.95	0.72	Other	102	186
229	PERI.baseline	0.97	Nonsignificant	0.13	1.37	Other	39	66
230	FIB.skin_sheath.ECM_immune	0.97	Nonsignificant	—	0.00	Other	0	0
231	B.germinal_center.LZ_selection	0.96	Nonsignificant	—	0.18	Other	0	0
232	EC.venous.cardiac_structural	0.96	Nonsignificant	0.91	0.91	Other	102	229
233	FIB.interstitial.mesenchymal_regulator	0.95	Nonsignificant	0.82	0.86	Other	4	4
234	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.95	Nonsignificant	—	0.97	Other	0	0
235	EPI.ileal_goblet.inflammatory_mucin	0.94	Nonsignificant	0.58	0.86	Other	6	9
236	EC.heart_remodeling.angiocrine	0.93	Nonsignificant	1.00	0.19	Other	182	525
237	HEP.canalicular_transport.pericentral_like_hypoxia	0.90	Nonsignificant	0.65	1.14	Other	326	8
238	MEL.mature_oxidative_traffic	0.89	Nonsignificant	0.21	1.31	Other	247	285
239	EPI.skin_keratinocyte_progenitor.activated_stress	0.89	Nonsignificant	—	0.38	Other	0	0
240	MAC.resident_cardiac.antigen_presenting	0.88	Nonsignificant	0.03	1.62	Other	52	27
241	EPI.salivary_serous_acinar.secretory_active	0.87	Nonsignificant	1.42e-12	2.70	Other	242	69
242	EPI.renal_thick_ascending_limb.barrier_repair	0.86	Nonsignificant	0.02	1.52	Other	141	284
243	T.CD8_Tem.TEMRA	0.86	Nonsignificant	1.05e-04	1.62	Other	920	1,088
244	EPI.skin_sebaceous_duct_luminal.detox_repair	0.85	Nonsignificant	1.00	0.00	Other	137	94
245	FIB.neurolectin_mucosa.inflammatory	0.83	Nonsignificant	0.83	0.79	Other	52	110
246	CM.mito_proteostasis	0.82	Nonsignificant	0.81	1.05	Other	329	29
247	EC.venous.adipose_lipid	0.78	Nonsignificant	1.00	0.50	Other	254	476
248	CM.osmoprotection	0.77	Nonsignificant	1.00	0.94	Other	34	57
249	EPI.extrahepatic_cholangiocyte.barrier_interface	0.77	Nonsignificant	—	0.73	Other	0	0
250	ASPC.baseline	0.76	Nonsignificant	1.00	0.48	Other	363	170
251	CM.translation_boost_RPL	0.76	Nonsignificant	0.35	1.24	Other	129	1
252	EPI.colonic_tuft.activated	0.75	Nonsignificant	—	0.00	Other	0	0
253	FIB.neurolectin_mucosa.axon_responsive	0.74	Nonsignificant	0.83	0.55	Other	10	10
254	EC.venous.baseline	0.74	Nonsignificant	1.00	0.08	Other	346	807
255	MEL.dedifferentiated_migratory	0.73	Nonsignificant	—	0.11	Other	0	0
256	FIB.lung_alveolar.mito_secretory	0.73	Nonsignificant	—	0.48	Other	0	0
257	EPI.skin_sebaceous_duct_luminal.immune_interface	0.72	Nonsignificant	—	0.00	Other	0	0
258	FIB.neurolectin_mucosa.remodeling_repair	0.71	Nonsignificant	—	0.00	Other	4	2
259	EPI.ileal_goblet.immature	0.70	Nonsignificant	—	0.00	Other	0	0
260	HEP.periportal_metabolic.stress_checkpoint	0.69	Nonsignificant	0.06	1.21	Other	234	786
261	EPI.colonic_enteroendocrine.Lcell_peptide	0.68	Nonsignificant	—	0.00	Other	0	0
262	CM.oxidative_phospho	0.68	Nonsignificant	1.00	0.65	Other	266	792
263	T.CD4_naive.activated_stress	0.68	Nonsignificant	0.56	1.25	Other	339	429
264	T.CD8_Tem.signaling_turnover	0.67	Nonsignificant	0.19	1.32	Other	425	683
265	MAC.kupffer.stress	0.67	Nonsignificant	0.95	0.29	Other	9	3
266	FIB.barrier_purinergic.stress_GF_binding	0.66	Nonsignificant	—	0.97	Other	0	0
267	MAC.resident_iron.stress_tolerogenic	0.66	Nonsignificant	—	0.00	Other	0	0
268	EPI.skin_keratinocyte_basal.spinous_transition	0.65	Nonsignificant	—	0.97	Other	0	0
269	EPI.esophageal_suprabasal.differentiating_keratin	0.65	Nonsignificant	6.45e-05	2.54	Other	131	61
270	EPI.skin_hair_follicle_bulge.quiescent	0.64	Nonsignificant	0.12	1.40	Other	56	69
271	CM.baseline	0.64	Nonsignificant	1.00	0.52	Other	393	0
272	EPI.ileal_bile_transport.absorptive_xenobiotic	0.63	Nonsignificant	0.10	1.78	Other	11	12
273	NEU.EXC_SYT2.synaptic	0.62	Nonsignificant	—	0.48	Other	0	0
274	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.61	Nonsignificant	—	0.00	Other	0	0
275	ASPC.niche_keeping_progenitor	0.60	Nonsignificant	1.00	0.26	Other	52	219
276	FIB.interstitial.remodeling	0.60	Nonsignificant	1.00	0.09	Other	31	9
277	ASPC.mesothelial_like	0.60	Nonsignificant	0.03	1.78	Other	143	486
278	EPI.skin_follicular_keratinizing.upper_infundibulum	0.60	Nonsignificant	—	0.31	Other	8	2
279	EPI.ileal_bile_transport.detox_transcytosis	0.58	Nonsignificant	—	0.00	Other	0	1
280	NEU.INH_LAMP5.rosehip	0.58	Nonsignificant	—	1.34	Other	0	0
281	EPI.renal_principal_cell.inflammatory	0.57	Nonsignificant	0.58	1.24	Other	74	157
282	EPI.renal_principal_cell.activated_acute	0.56	Nonsignificant	0.99	1.00	Other	29	59
283	MAC.microglia_like.patrolling_adhesive	0.55	Nonsignificant	—	0.00	Other	0	0
284	EPI.skin_follicular_keratinizing.root_infundibulum	0.55	Nonsignificant	—	0.13	Other	0	0
285	PERI.cardiac_skeletal	0.52	Nonsignificant	1.00	0.16	Other	313	630
286	NK.immature_bridge	0.52	Nonsignificant	1.00	0.10	Other	117	122
287	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.52	Nonsignificant	0.75	1.05	Other	322	317
288	IPSC.midbrain_primed	0.52	Nonsignificant	0.46	1.08	Other	0	0
289	HEP.pericentral_lipoprotein.ApoB_coagulation	0.52	Nonsignificant	—	0.67	Other	0	0
290	HEP.canalicular_transport.injury_stress	0.51	Nonsignificant	0.67	1.08	Other	289	24
291	HEP.acute_phase.hypoxia_lipid	0.50	Nonsignificant	—	0.00	Other	0	0
292	EPI.skin_sweat_duct_keratinocyte.barrier	0.50	Nonsignificant	—	1.36	Other	0	0
293	EPI.skin_keratinocyte_basal.transit_amplifying	0.49	Nonsignificant	—	0.00	Other	0	0
294	EC.heart_remodeling.translation_boost	0.49	Nonsignificant	—	0.00	Other	0	0
295	ASTRO.stress_acute	0.49	Nonsignificant	1.00	1.03	Other	60	56
296	EPI.esophageal_suprabasal.proliferative_G2M	0.48	Nonsignificant	—	0.00	Other	0	0
297	EPI.renal_intercalated_cell_type_A.acid_secretion	0.48	Nonsignificant	0.03	1.54	Other	12	6
298	EPI.renal_thick_ascending_limb.cation_flux	0.48	Nonsignificant	0.75	1.03	Other	57	95
299	FIB.perivascular_interface.vasomotor_tone	0.48	Nonsignificant	—	0.52	Other	0	0
300	T.CD8_Tem.motility_primed	0.47	Nonsignificant	1.00	0.80	Other	269	4
301	FIB.lung_alveolar.stress_interacting	0.47	Nonsignificant	—	0.00	Other	0	0
302	NEU.INH_LAMP5.glial_interface	0.47	Nonsignificant	—	0.53	Other	0	0
303	EC.arterial.metabolic	0.46	Nonsignificant	1.00	0.16	Other	195	159
304	MAC.kupffer.inflammatory	0.46	Nonsignificant	—	0.00	Other	7	4
305	EPI.skin_follicular_keratinizing.transit_amplifying	0.46	Nonsignificant	—	0.00	Other	21	49
306	HEP.pericentral_lipoprotein.UPR_redox	0.46	Nonsignificant	—	0.00	Other	0	0
307	ASPC.secretory	0.45	Nonsignificant	1.00	0.05	Other	76	5
308	MEL.secretory_quiescent	0.45	Nonsignificant	0.96	0.72	Other	19	13
309	FIB.perivascular_interface.lipid_shuttle	0.45	Nonsignificant	—	0.16	Other	51	170
310	OPC.proliferative_immune_interact	0.44	Nonsignificant	0.04	1.88	Other	180	373
311	NEU.EXC_CT.projector	0.43	Nonsignificant	0.07	1.25	Other	87	26
312	MEL.neurotrophic_migratory	0.42	Nonsignificant	—	0.07	Other	0	0
313	FIB.adventitial.inflammatory_activated	0.42	Nonsignificant	5.10e-03	1.26	Other	100	473
314	NK.cytokine_tissue_resident	0.41	Nonsignificant	1.00	0.12	Other	74	82
315	T.CD8_Tem.stress_adapted	0.41	Nonsignificant	1.00	0.79	Other	607	520
316	EPI.salivary_myoepithelial.baseline	0.41	Nonsignificant	0.07	1.90	Other	42	141
317	EPI.esophageal_suprabasal.proliferative_exit	0.40	Nonsignificant	—	0.00	Other	0	0
318	PC.IgA_muocsal.plasmablast	0.40	Nonsignificant	0.05	1.43	Other	5	4
319	EC.arterial.homeostatic	0.39	Nonsignificant	1.00	0.09	Other	24	3
320	EPI.salivary_myoepithelial.contractile_repair	0.39	Nonsignificant	—	0.53	Other	3	9
321	EC.arterial.elastic	0.38	Nonsignificant	1.00	0.25	Other	22	45
322	CM.contractile_oxphos	0.38	Nonsignificant	1.00	0.20	Other	6	19
323	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.38	Nonsignificant	—	0.00	Other	0	0
324	T.CD8_Tem.baseline	0.38	Nonsignificant	1.00	0.75	Other	458	356
325	NK.adaptive_terminal_cytotoxic	0.37	Nonsignificant	1.00	0.03	Other	485	802
326	EPI.skin_hair_follicle_bulge.anagen_growth	0.37	Nonsignificant	—	0.00	Other	0	0
327	CM.translation_boost_RPS	0.37	Nonsignificant	1.00	0.16	Other	69	16
328	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.36	Nonsignificant	3.81e-03	1.50	Other	11	22
329	T.CD4_transitional.tissue_enagement	0.36	Nonsignificant	0.63	1.23	Other	5	11
330	EPI.endocervical_secretory.secretory_translocon	0.36	Nonsignificant	—	0.67	Other	0	0
331	NK.adaptive_immature_precursor	0.35	Nonsignificant	1.00	0.03	Other	358	111
332	EPI.tracheal_suprabasal.transitional_wound	0.35	Nonsignificant	—	0.60	Other	16	1
333	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.35	Nonsignificant	—	1.24	Other	0	0
334	HEP.periportal_metabolic.acute_phase_barrier	0.35	Nonsignificant	0.28	1.12	Other	533	138
335	FIB.perivascular_interface.vascular_BM_remodelling	0.34	Nonsignificant	—	0.00	Other	0	0
336	EPI.esophageal_basal.junctional_barrier	0.34	Nonsignificant	—	0.00	Other	0	0
337	FIB.suburothelial.urothelial_interface	0.34	Nonsignificant	9.74e-03	2.57	Other	9	8
338	NEU.INH_LAMP5.projecting	0.34	Nonsignificant	—	6.94e-17	Other	0	0
339	T.CD8_Tem.early_helper_like	0.34	Nonsignificant	1.00	0.57	Other	445	755
340	OPC.premyelinating	0.33	Nonsignificant	0.92	0.58	Other	185	12
341	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.33	Nonsignificant	—	0.00	Other	0	0
342	MAC.kupffer.fibrogenic	0.33	Nonsignificant	—	0.00	Other	0	0
343	B.memory.preactivated	0.33	Nonsignificant	0.01	1.18	Other	173	174
344	FIB.skin_neurosecretory.baseline	0.32	Nonsignificant	—	0.00	Other	0	0
345	ILC2.activated	0.32	Nonsignificant	—	6.94e-17	Other	0	0
346	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.32	Nonsignificant	—	0.73	Other	0	0
347	EPI.renal_thick_ascending_limb.remodeling	0.32	Nonsignificant	0.97	0.68	Other	152	92
348	EPI.esophageal_basal.activated_progenitor	0.32	Nonsignificant	0.58	1.00	Other	1	0
349	EPI.esophageal_suprabasal.proliferative_S	0.32	Nonsignificant	—	0.00	Other	26	41
350	B.naive.restrained	0.32	Nonsignificant	4.99e-03	1.15	Other	183	353
351	MG.baseline	0.31	Nonsignificant	0.14	1.22	Other	16	5
352	OPC.homeostatic	0.31	Nonsignificant	0.92	0.48	Other	394	160
353	HEP.canalicular_transport.baseline	0.31	Nonsignificant	1.00	0.60	Other	199	477
354	EPI.salivary_myoepithelial.activated	0.31	Nonsignificant	1.00	0.55	Other	85	281
355	B.germinal_center.DZ_S_phase	0.31	Nonsignificant	—	0.00	Other	0	0
356	EPI.ileal_enterocyte_crypt.villus_transition	0.30	Nonsignificant	—	1.62	Other	7	10
357	EPI.ectocervical_granular.proliferative_basal	0.29	Nonsignificant	—	0.00	Other	0	0
358	EPI.esophageal_suprabasal.basal_transitional	0.28	Nonsignificant	1.00	0.00	Other	44	67
359	NEU.INH_PVALB.serotonergic	0.28	Nonsignificant	—	1.16	Other	0	0
360	NEU.INH_PVALB.metabotropic	0.28	Nonsignificant	—	1.04	Other	0	0
361	ILC2.migratory	0.28	Nonsignificant	—	0.35	Other	0	0
362	DC.pDC.immature_metabolic	0.27	Nonsignificant	0.94	0.48	Other	78	124
363	DC.pDC.baseline	0.27	Nonsignificant	0.94	0.77	Other	88	123
364	ASTRO.hypoxia_angiogenic	0.26	Nonsignificant	1.00	1.03	Other	5	18
365	EPI.ileal_enterocyte_absorptive.villus_tip	0.26	Nonsignificant	5.45e-05	2.09	Other	4	3
366	B.germinal_center.DZ_M_phase	0.26	Nonsignificant	—	0.00	Other	0	0
367	EPI.skin_sweat_duct_keratinocyte.repair	0.26	Nonsignificant	—	0.57	Other	0	0
368	PC.IgG_systemic.interacting	0.25	Nonsignificant	0.38	1.32	Other	0	0
369	NEU.INH_PVALB.neuromodulatory	0.25	Nonsignificant	—	1.12	Other	0	0
370	FIB.suburothelial.contractile_myofibroblast	0.25	Nonsignificant	—	0.00	Other	9	0
371	EPI.salivary_myoepithelial.junctional_transport	0.25	Nonsignificant	1.00	0.00	Other	66	121
372	T.CD4_Th2.tissue_adapted	0.25	Nonsignificant	—	0.00	Other	0	0
373	FIB.adventitial.adhesion_lipid	0.24	Nonsignificant	1.00	1.07	Other	58	209
374	FIB.suburothelial.homeostasis_matrix	0.24	Nonsignificant	0.96	0.09	Other	258	921
375	FIB.suburothelial.inflammatory_prostanoid	0.23	Nonsignificant	—	0.00	Other	0	0
376	HEP.canalicular_transport.ductular_like_transition	0.23	Nonsignificant	1.00	0.28	Other	400	87
377	EPI.colonic_enteroendocrine.progenitor	0.23	Nonsignificant	—	0.00	Other	0	0
378	MEL.stress_glucocorticoid	0.21	Nonsignificant	0.96	0.49	Other	11	34
379	EPI.skin_keratinocyte_proliferating.detox_repair	0.21	Nonsignificant	—	1.13	Other	0	0
380	T.CD4_Treg.tissue_effector	0.21	Nonsignificant	0.29	1.16	Other	16	13
381	EPI.endocervical_secretory.squamous_barrier	0.20	Nonsignificant	—	0.00	Other	0	0
382	IPSC.neuroendocrine_primed	0.20	Nonsignificant	—	1.37	Other	0	0
383	PC.IgG_systemic.secretory	0.20	Nonsignificant	0.38	1.21	Other	0	0
384	EPI.pancreatic_islet.alpha	0.20	Nonsignificant	—	0.74	Other	152	330
385	ILC2.quiescent	0.20	Nonsignificant	—	0.00	Other	0	0
386	T.CD4_Th2.precursor	0.19	Nonsignificant	—	0.00	Other	0	0
387	HEP.canalicular_transport.secretory_ERAD_UPR	0.19	Nonsignificant	1.00	0.19	Other	232	28
388	T.CD4_Tfh.effector_migratory	0.19	Nonsignificant	0.48	1.22	Other	122	57
389	SCHWN.reactive_inflammatory	0.19	Nonsignificant	—	0.81	Other	0	0
390	NEU.EXC_CT.Ca2_signaling	0.18	Nonsignificant	—	0.20	Other	68	17
391	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	0.18	Nonsignificant	—	0.18	Other	0	0
392	IPSC.endoderm_primed	0.18	Nonsignificant	1.00	1.04	Other	0	0
393	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.18	Nonsignificant	—	0.00	Other	29	88
394	IPSC.neural_primed	0.18	Nonsignificant	0.46	1.04	Other	0	0
395	NEU.INH_LAMP5.exc_inh_balance	0.17	Nonsignificant	—	0.00	Other	46	2
396	EPI.tracheal_submucosal_gland.acinar_serous	0.17	Nonsignificant	—	0.42	Other	0	0
397	MAC.resident_cardiac.inflammatory_reparative	0.15	Nonsignificant	0.27	1.32	Other	31	96
398	NEU.INH_PVALB.fastspike	0.15	Nonsignificant	—	0.22	Other	24	22
399	NEU.EXC_NTNG1.synaptic	0.14	Nonsignificant	—	0.67	Other	0	0
400	PC.IgG_systemic.metabolic	0.14	Nonsignificant	0.79	0.77	Other	46	63
401	EPI.tracheal_submucosal_gland.ductal_luminal	0.14	Nonsignificant	—	0.00	Other	0	0
402	EPI.ileal_enterocyte_crypt.secretory_precursor	0.13	Nonsignificant	—	1.00	Other	0	0
403	IPSC.mesenchymal_primed	0.13	Nonsignificant	0.23	1.06	Other	0	0
404	NEU.EXC_SYT2.nuclear_reg	0.13	Nonsignificant	—	0.00	Other	0	0
405	T.CD8_Trm.dendritic_recruiter	0.12	Nonsignificant	0.54	1.13	Other	47	85
406	EPI.renal_distal_tubule.repair	0.12	Nonsignificant	—	0.07	Other	34	102
407	NEU.INH_PVALB.chandelier	0.12	Nonsignificant	1.00	0.60	Other	19	16
408	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.12	Nonsignificant	0.39	1.16	Other	219	533
409	EPI.skin_hair_follicle_companion.activated_migratory	0.11	Nonsignificant	—	0.97	Other	0	0
410	NEU.EXC_NTNG1.nuclear_reg	0.11	Nonsignificant	—	0.00	Other	0	0
411	HEP.periportal_metabolic.xenobiotic_detox	0.11	Nonsignificant	0.28	1.07	Other	1,440	139
412	EPI.renal_distal_tubule.stress	0.11	Nonsignificant	—	0.71	Other	0	0
413	PC.IgA_muocsal.migratory	0.11	Nonsignificant	0.93	0.94	Other	4	1
414	T.CD8_transitional.effector_primed	0.11	Nonsignificant	0.21	1.10	Other	435	151
415	T.CD4_Trm.metal_stress	0.10	Nonsignificant	0.39	1.22	Other	34	58
416	PC.IgG_systemic.stress	0.10	Nonsignificant	—	0.00	Other	1	5
417	PC.IgA_muocsal.baseline	0.10	Nonsignificant	0.93	0.93	Other	3	5
418	T.CD4_transitional.primed_cytotoxic	0.10	Nonsignificant	0.86	1.00	Other	28	30
419	EPI.renal_thick_ascending_limb.salt_sensing	0.09	Nonsignificant	0.97	0.57	Other	73	103
420	EPI.renal_distal_tubule.ion_transport	0.09	Nonsignificant	—	0.40	Other	0	0
421	EPI.renal_intercalated_cell_type_A.PC_transitional	0.09	Nonsignificant	—	0.00	Other	203	407
422	T.CD8_transitional.stress	0.09	Nonsignificant	—	0.85	Other	24	34
423	T.CD4_Trm.activated	0.09	Nonsignificant	0.94	1.08	Other	32	26
424	MAC.resident_cardiac.phagocytic_homeostasis	0.08	Nonsignificant	0.99	0.47	Other	564	1,221
425	B.naive.activated	0.08	Nonsignificant	1.00	0.94	Other	77	127
426	FIB.adventitial.PI16_matrix	0.08	Nonsignificant	1.00	0.89	Other	70	90
427	EPI.renal_principal_cell.canonical_vasopressin	0.08	Nonsignificant	0.99	0.82	Other	2	0
428	EPI.skin_keratinocyte_basal.basement_anchoring	0.07	Nonsignificant	—	0.00	Other	0	0
429	ASTRO.immature_lipid	0.07	Nonsignificant	1.00	0.92	Other	23	113
430	EPI.tracheal_suprabasal.secretory_immune	0.07	Nonsignificant	—	0.00	Other	0	0
431	HEP.periportal_metabolic.canonical_urea_cycle	0.07	Nonsignificant	0.87	1.00	Other	1,464	269
432	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.07	Nonsignificant	—	0.00	Other	0	0
433	EPI.ileal_enterocyte_crypt.bile_transport	0.07	Nonsignificant	0.97	0.99	Other	2	0
434	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.07	Nonsignificant	—	0.78	Other	0	0
435	B.naive.proteostasis	0.07	Nonsignificant	1.00	0.99	Other	49	69
436	NEU.EXC_CT.remodeling	0.07	Nonsignificant	—	0.00	Other	23	1
437	IPSC.stress	0.07	Nonsignificant	1.00	0.95	Other	0	0
438	T.CD4_Tcm.Th2_like	0.07	Nonsignificant	0.39	1.18	Other	23	55
439	T.CD4_transitional.APC_interacting	0.07	Nonsignificant	0.82	1.11	Other	10	14
440	FIB.barrier_purinergic.lipid_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
441	NEU.INH_VIP.LAMP5_hybrid	0.06	Nonsignificant	—	1.75	Other	1	9
442	T.CD8_Trm.inflammatory	0.06	Nonsignificant	0.54	1.08	Other	124	176
443	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.06	Nonsignificant	—	0.18	Other	0	0
444	EPI.ileal_enterocyte_absorptive.brush_border	0.06	Nonsignificant	1.00	0.00	Other	580	1,717
445	SCHWN.translation_boost	0.06	Nonsignificant	—	0.38	Other	8	1
446	PC.IgA_muocsal.activated	0.06	Nonsignificant	0.98	0.74	Other	17	8
447	B.naive.antigen_presenting_ready	0.06	Nonsignificant	1.00	1.01	Other	48	73
448	T.gamma_delta.cytotoxic_effector	0.06	Nonsignificant	0.06	1.14	Other	349	109
449	EPI.renal_immature_ureteric_bud.osmoprotective	0.06	Nonsignificant	0.07	1.21	Other	126	44
450	EPI.salivary_duct_excretory.baseline	0.06	Nonsignificant	2.63e-03	1.17	Other	23	57
451	EPI.lung_club_secretory.ciliogenesis_axoneme	0.05	Nonsignificant	—	0.00	Other	0	0
452	T.CD4_cytotoxic.terminal_effector	0.05	Nonsignificant	0.02	1.28	Other	286	21
453	T.CD4_Trm.cytotoxic_effector	0.05	Nonsignificant	0.22	1.16	Other	118	77
454	T.CD8_transitional.Trm_primed	0.05	Nonsignificant	0.87	1.01	Other	108	15
455	T.CD4_Trm.baseline	0.05	Nonsignificant	1.00	0.98	Other	31	21
456	MG.phagocytic_APC	0.05	Nonsignificant	0.97	0.55	Other	25	8
457	EPI.thymic_medullary.proliferative_APC	0.05	Nonsignificant	—	0.94	Other	0	0
458	NEU.EXC_IT.callosal	0.05	Nonsignificant	0.76	1.14	Other	286	119
459	T.CD8_Trm.homeostatic	0.04	Nonsignificant	1.00	0.94	Other	42	5
460	NEU.EXC_IT.structural	0.04	Nonsignificant	0.86	1.03	Other	171	41
461	NEU.INH_PVALB.nuclear_reg	0.04	Nonsignificant	1.00	0.00	Other	25	12
462	MG.expanding	0.04	Nonsignificant	0.97	0.67	Other	2	1
463	ASTRO.neuromodulatory	0.04	Nonsignificant	1.00	0.75	Other	34	172
464	T.CD4_Th17.migratory	0.04	Nonsignificant	0.27	1.13	Other	13	23
465	T.CD4_Tcm.Tfh_like	0.04	Nonsignificant	0.75	1.08	Other	102	214
466	T.CD4_Tfh.suppression_exhaustion	0.04	Nonsignificant	0.76	1.09	Other	0	2
467	T.CD4_transitional.baseline	0.04	Nonsignificant	0.86	0.88	Other	59	97
468	EPI.thymic_medullary.stress_APC	0.04	Nonsignificant	0.16	1.61	Other	2	4
469	EPI.renal_intercalated_cell_type_B.baseline	0.03	Nonsignificant	—	0.00	Other	3	1
470	FIB.adventitial.complement_angiocrine	0.03	Nonsignificant	1.00	0.67	Other	153	684
471	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.03	Nonsignificant	—	0.00	Other	0	0
472	ASTRO.A2_reactive	0.03	Nonsignificant	1.00	0.85	Other	10	37
473	T.CD4_cytotoxic.NK_adapted	0.03	Nonsignificant	1.00	0.96	Other	82	33
474	T.CD4_transitional.primed_helper_effector	0.03	Nonsignificant	0.86	0.86	Other	19	43
475	T.CD8_Trm.cytotoxic	0.03	Nonsignificant	1.00	0.91	Other	165	85
476	EPI.pancreatic_acinar.stress	0.03	Nonsignificant	0.76	1.17	Other	28	28
477	EPI.pancreatic_ductal_bicarbonate.stress	0.03	Nonsignificant	—	0.34	Other	12	33
478	EPI.salivary_serous_acinar.quiescent	0.02	Nonsignificant	1.00	0.03	Other	178	493
479	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.02	Nonsignificant	—	0.58	Other	0	0
480	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.02	Nonsignificant	—	0.00	Other	43	26
481	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.02	Nonsignificant	—	0.42	Other	5	3
482	T.CD4_Trm.central_like	0.02	Nonsignificant	1.00	0.87	Other	38	31
483	THYMO.SP_CD8_naive_stress	0.02	Nonsignificant	0.26	1.18	Other	1	1
484	EPI.renal_principal_cell.intercalated_like	0.02	Nonsignificant	0.99	0.84	Other	63	66
485	EPI.ileal_enterocyte_crypt.baseline	0.02	Nonsignificant	0.97	0.84	Other	11	6
486	T.CD4_Trm.stress_adaptive	0.02	Nonsignificant	1.00	0.91	Other	8	22
487	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.02	Nonsignificant	0.59	1.09	Other	33	34
488	EPI.hepatic_ductular_cholangiocyte.polarity	0.02	Nonsignificant	—	0.22	Other	0	0
489	HEP.periportal_metabolic.apolipoprotein_secretory	0.02	Nonsignificant	1.00	0.88	Other	43	110
490	HEP.periportal_metabolic.urea_onecarbon_secretory	0.02	Nonsignificant	1.00	0.83	Other	1,332	3,053
491	T.CD4_Tfh.precursor_migratory	0.02	Nonsignificant	0.76	0.95	Other	72	27
492	EPI.salivary_intercalated_defense.inflammatory	0.02	Nonsignificant	1.00	0.12	Other	152	360
493	EPI.pancreatic_acinar.inflammatory_regenerative	0.02	Nonsignificant	0.76	1.23	Other	25	113
494	EPI.thymic_medullary.hormone_xeno_barrier	0.02	Nonsignificant	—	0.00	Other	0	8
495	B.naive.remodeling	0.02	Nonsignificant	0.14	1.12	Other	135	230
496	FIB.adventitial.mito_secretory	0.02	Nonsignificant	1.00	0.65	Other	21	7
497	HEP.periportal_metabolic.stress_chaperone	0.02	Nonsignificant	—	0.29	Other	66	128
498	EPI.thymic_medullary.canonical_alarmin	0.01	Nonsignificant	0.98	0.18	Other	8	17
499	T.CD4_Tfh.canonical_GC_helper	0.01	Nonsignificant	0.76	0.85	Other	1	2
500	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.01	Nonsignificant	0.59	0.99	Other	7	16
501	T.CD4_cytotoxic.activated	0.01	Nonsignificant	1.00	0.78	Other	3	1
502	THYMO.proliferative_S	0.01	Nonsignificant	0.26	1.12	Other	163	418
503	EPI.salivary_serous_acinar.seromucous_like	0.01	Nonsignificant	—	0.00	Other	0	0
504	NEU.EXC_IT.transitional	0.01	Nonsignificant	0.76	1.13	Other	237	142
505	EPI.ileal_enterocyte_crypt.proliferative_S	0.01	Nonsignificant	0.97	0.47	Other	4	2
506	EPI.skin_interfollicular_spinous.transition_basal	0.01	Nonsignificant	0.67	1.27	Other	100	127
507	ASPC.signal_integrator	0.01	Nonsignificant	—	0.00	Other	0	0
508	THYMO.DN_preTCR	0.01	Nonsignificant	0.26	1.10	Other	41	71
509	NEU.EXC_IT.guidance	0.01	Nonsignificant	1.00	0.81	Other	274	63
510	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	0.23	1.12	Other	314	587
511	T.CD4_Th17.baseline	9.91e-03	Nonsignificant	0.64	1.02	Other	51	5
512	B.memory.activated	9.87e-03	Nonsignificant	1.00	0.88	Other	105	29
513	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	9.63e-03	Nonsignificant	—	0.00	Other	6	9
514	EPI.skin_hair_follicle_companion.gap_junction_contractile	9.38e-03	Nonsignificant	—	0.00	Other	0	0
515	T.gamma_delta.early_effector	9.27e-03	Nonsignificant	1.00	0.87	Other	89	0
516	FIB.adventitial.mechano_chemo_sensing	8.51e-03	Nonsignificant	1.00	0.32	Other	135	524
517	T.CD4_Tem.inflammatory	8.43e-03	Nonsignificant	0.31	1.09	Other	28	6
518	EPI.ectocervical_granular.immune_interact	7.97e-03	Nonsignificant	—	0.00	Other	0	0
519	T.CD4_Tcm.migratory_cilium	7.55e-03	Nonsignificant	0.75	1.10	Other	5	10
520	NEU.INH_VIP.enkephalinergic	7.48e-03	Nonsignificant	—	1.23	Other	0	0
521	B.naive.purinergic	7.28e-03	Nonsignificant	1.00	0.70	Other	384	820
522	T.CD8_transitional.early	7.22e-03	Nonsignificant	0.99	0.93	Other	327	55
523	IPSC.canonical_pluripotent	6.71e-03	Nonsignificant	1.00	0.90	Other	0	0
524	EPI.skin_sweat_duct_keratinocyte.proliferative_S	6.61e-03	Nonsignificant	—	0.00	Other	0	0
525	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	6.30e-03	Nonsignificant	—	0.42	Other	0	0
526	T.CD8_transitional.APC_like	6.26e-03	Nonsignificant	0.99	0.83	Other	205	62
527	T.CD4_Tcm.stress	6.18e-03	Nonsignificant	0.75	1.14	Other	5	11
528	EPI.skin_interfollicular_spinous.inflammatory	5.76e-03	Nonsignificant	—	1.14	Other	0	0
529	EPI.skin_appendage_keratinocyte.transit_amplifying	5.60e-03	Nonsignificant	—	0.00	Other	109	358
530	EPI.gastric_foveolar.baseline	5.53e-03	Nonsignificant	—	0.00	Other	0	0
531	EPI.renal_principal_cell.injury_repair	5.35e-03	Nonsignificant	0.99	0.44	Other	26	9
532	B.memory.migratory	5.17e-03	Nonsignificant	1.00	0.79	Other	123	208
533	THYMO.SP_CD8_transitional	5.17e-03	Nonsignificant	0.85	1.06	Other	32	75
534	B.naive.metabolic	5.13e-03	Nonsignificant	1.00	0.74	Other	50	79
535	OLG.stress	5.11e-03	Nonsignificant	0.09	1.08	Other	232	8
536	B.naive.baseline	4.69e-03	Nonsignificant	1.00	0.82	Other	10	13
537	T.CD8_naive.nfkb_related	4.55e-03	Nonsignificant	0.86	1.19	Other	1	0
538	EPI.renal_distal_tubule.ciliated_remodelling	4.48e-03	Nonsignificant	—	0.00	Other	0	0
539	EPI.skin_interfollicular_spinous.stress_oxidative	4.37e-03	Nonsignificant	—	0.73	Other	0	0
540	T.CD4_Tcm.imprinted_splicing	4.35e-03	Nonsignificant	0.81	1.08	Other	6	17
541	SCHWN.axon_contact_cardiac	4.33e-03	Nonsignificant	0.97	0.27	Other	18	63
542	B.memory.baseline	4.25e-03	Nonsignificant	1.00	0.69	Other	472	99
543	T.CD4_cytotoxic.baseline	4.20e-03	Nonsignificant	1.00	0.61	Other	0	0
544	EPI.pancreatic_islet.beta	4.02e-03	Nonsignificant	0.85	0.72	Other	42	57
545	EPI.cervical_suprabasal.inflammatory_repair	3.84e-03	Nonsignificant	—	0.42	Other	0	0
546	T.CD4_Tcm.tissue_homing	3.75e-03	Nonsignificant	0.81	1.02	Other	78	46
547	T.CD4_Tcm.regulatory_poised	3.53e-03	Nonsignificant	0.81	1.06	Other	2	3
548	FIB.adventitial.baseline	3.46e-03	Nonsignificant	1.00	0.10	Other	157	278
549	EPI.hepatic_ductular_cholangiocyte.secretory_transport	3.42e-03	Nonsignificant	—	0.00	Other	0	0
550	T.CD4_Treg.APC_interactive	3.39e-03	Nonsignificant	0.98	0.81	Other	118	28
551	EPI.pancreatic_ductal_perivascular.baseline	3.36e-03	Nonsignificant	0.46	1.16	Other	1	5
552	T.CD4_Tem.cytotoxic_effector	3.05e-03	Nonsignificant	0.79	0.99	Other	225	398
553	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	3.02e-03	Nonsignificant	—	0.00	Other	0	0
554	T.CD8_Trm.muscosal_Tc17	2.88e-03	Nonsignificant	1.00	0.37	Other	19	38
555	THYMO.DP_early_stress	2.84e-03	Nonsignificant	—	1.01	Other	0	0
556	T.CD8_naive.cytokine_dampened	2.75e-03	Nonsignificant	0.86	1.09	Other	71	4
557	T.CD4_Tcm.baseline	2.66e-03	Nonsignificant	0.81	1.01	Other	61	31
558	EPI.lung_club_secretory.canonical_surfactant	2.66e-03	Nonsignificant	—	0.00	Other	74	104
559	T.CD4_Tcm.DC_interact	2.63e-03	Nonsignificant	0.81	1.01	Other	72	32
560	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.57e-03	Nonsignificant	—	0.32	Other	0	0
561	EPI.colonocyte.proximal_transport	2.53e-03	Nonsignificant	0.48	1.26	Other	24	12
562	EPI.alveolar_type_1.activated	2.52e-03	Nonsignificant	—	1.64	Other	0	0
563	EPI.renal_immature_ureteric_bud.defense_secretory	2.38e-03	Nonsignificant	0.98	0.39	Other	45	76
564	NEU.INH_VIP.serotonergic	2.35e-03	Nonsignificant	—	0.23	Other	9	2
565	EPI.salivary_duct_ion_transport.baseline	2.30e-03	Nonsignificant	—	—	Other	0	0
566	T.CD4_naive.homeostatic	2.27e-03	Nonsignificant	0.99	1.01	Other	215	108
567	EPI.hepatic_ductular_cholangiocyte.stress	1.78e-03	Nonsignificant	—	0.00	Other	0	0
568	NEU.EXC_IT.neuromodulated	1.67e-03	Nonsignificant	1.00	0.89	Other	176	116
569	EPI.pancreatic_islet.delta	1.62e-03	Nonsignificant	—	0.13	Other	0	0
570	EPI.salivary_intercalated_defense.basal_EMT	1.55e-03	Nonsignificant	—	0.00	Other	0	0
571	T.CD4_naive.mature	1.49e-03	Nonsignificant	0.99	0.98	Other	211	100
572	EPI.colonocyte.goblet_interface	1.43e-03	Nonsignificant	—	0.58	Other	11	21
573	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.42e-03	Nonsignificant	—	0.00	Other	19	54
574	EPI.pancreatic_ductal_bicarbonate.baseline	1.40e-03	Nonsignificant	0.97	0.74	Other	11	42
575	EPI.colonocyte.distal_absorptive	1.35e-03	Nonsignificant	—	0.70	Other	0	0
576	T.CD4_Trm.helper_like	1.33e-03	Nonsignificant	1.00	0.46	Other	84	147
577	EPI.colonocyte.crypt_progenitor	1.27e-03	Nonsignificant	0.96	0.94	Other	115	265
578	T.CD4_Th17.cytotoxic	1.12e-03	Nonsignificant	0.86	0.90	Other	332	123
579	EPI.lung_club_secretory.ciliogenesis_primed	1.08e-03	Nonsignificant	—	0.00	Other	0	0
580	EPI.pancreatic_ductal_perivascular.protective_antioxidant	1.07e-03	Nonsignificant	—	0.00	Other	11	69
581	EPI.pancreatic_ductal_bicarbonate.inflammatory	1.02e-03	Nonsignificant	0.97	0.96	Other	14	32
582	IPSC.stromal_primed	9.52e-04	Nonsignificant	1.00	0.81	Other	0	0
583	ASTRO.stress_mito	8.93e-04	Nonsignificant	1.00	0.63	Other	47	110
584	NEU.INH_VIP.matrix	8.46e-04	Nonsignificant	—	0.22	Other	24	77
585	THYMO.DP_early	8.32e-04	Nonsignificant	1.00	0.94	Other	326	313
586	EPI.skin_interfollicular_spinous.upper_lipid	8.23e-04	Nonsignificant	—	0.40	Other	6	6
587	EPI.skin_keratinocyte_proliferating.early_spinous_transition	8.09e-04	Nonsignificant	—	0.00	Other	135	290
588	NEU.INH_VIP.regulatory_remodeling	7.90e-04	Nonsignificant	—	0.56	Other	6	1
589	T.CD8_Tcm.gut_homing	7.72e-04	Nonsignificant	0.07	1.17	Other	380	112
590	EPI.cervical_suprabasal.secretory_vesicle	7.37e-04	Nonsignificant	—	0.00	Other	0	0
591	EPI.pancreatic_acinar.quiet_dedifferentiation	7.28e-04	Nonsignificant	0.98	1.09	Other	142	171
592	T.CD4_Treg.central_naive_like	6.43e-04	Nonsignificant	0.98	0.82	Other	333	45
593	T.CD4_Tcm.crosstalk_myeloid	6.32e-04	Nonsignificant	0.81	1.00	Other	5	4
594	T.MAIT.early_activation	6.30e-04	Nonsignificant	0.44	1.16	Other	57	4
595	NEU.INH_VIP.develop_niche	6.29e-04	Nonsignificant	—	0.63	Other	0	0
596	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	6.20e-04	Nonsignificant	—	0.00	Other	39	82
597	EPI.colonocyte.junction_remodeling	5.85e-04	Nonsignificant	0.96	0.82	Other	218	305
598	T.CD4_Tcm.effector_like	4.64e-04	Nonsignificant	0.95	0.90	Other	293	533
599	EPI.skin_interfollicular_spinous.early_differentiation	4.60e-04	Nonsignificant	0.96	0.47	Other	89	19
600	EPI.colonocyte.ionocyte_BEST4	4.50e-04	Nonsignificant	0.96	1.01	Other	103	188
601	EPI.salivary_duct_excretory.stress	4.49e-04	Nonsignificant	0.98	0.14	Other	33	68
602	T.MAIT.migratory	4.27e-04	Nonsignificant	0.79	1.12	Other	10	1
603	T.CD4_Tcm.secretory	4.11e-04	Nonsignificant	0.81	1.00	Other	20	11
604	EPI.lung_multiciliated.baseline	3.88e-04	Nonsignificant	—	0.51	Other	0	7
605	T.CD4_Tcm.retro_ZNF117	3.71e-04	Nonsignificant	0.81	1.00	Other	5	9
606	T.CD4_Tcm.APC_mimicry	3.65e-04	Nonsignificant	0.95	0.91	Other	54	43
607	T.CD4_naive.resist_bystander	3.63e-04	Nonsignificant	0.99	1.01	Other	40	25
608	T.CD8_naive.splicing_enriched	3.17e-04	Nonsignificant	0.92	0.99	Other	120	16
609	IPSC.mesodermal_primed	2.94e-04	Nonsignificant	1.00	0.88	Other	0	0
610	EPI.skin_interfollicular_spinous.stress_UPR	2.85e-04	Nonsignificant	—	0.00	Other	0	0
611	T.CD4_naive.mature_mitoprot	2.83e-04	Nonsignificant	0.99	0.93	Other	212	476
612	ASTRO.synaptic_interaction	2.80e-04	Nonsignificant	1.00	0.50	Other	76	334
613	EPI.skin_interfollicular_spinous.proliferative	2.79e-04	Nonsignificant	—	0.00	Other	0	0
614	B.naive.receptor_recycle	2.76e-04	Nonsignificant	1.00	0.51	Other	51	0
615	EPI.alveolar_type_1.baseline	2.70e-04	Nonsignificant	1.00	0.00	Other	8	0
616	EPI.skin_interfollicular_spinous.baseline	2.62e-04	Nonsignificant	0.96	0.44	Other	35	3
617	T.CD4_naive.Treg_like	2.54e-04	Nonsignificant	0.99	1.23	Other	121	72
618	OLG.regulatory_activated	2.46e-04	Nonsignificant	0.35	1.15	Other	196	614
619	IPSC.proliferative	2.45e-04	Nonsignificant	1.00	0.76	Other	0	0
620	T.CD4_naive.survival	2.43e-04	Nonsignificant	0.99	1.09	Other	12	17
621	OLG.myelinating_mature	2.37e-04	Nonsignificant	0.95	1.02	Other	363	94
622	T.CD8_naive.vesicle_secretory	2.13e-04	Nonsignificant	0.86	1.09	Other	42	0
623	HEP.periportal_metabolic.inflammatory_activated	2.10e-04	Nonsignificant	1.00	0.77	Other	712	1,610
624	EPI.lung_multiciliated.mature_motile_cilia	2.05e-04	Nonsignificant	—	0.16	Other	0	0
625	T.CD4_Tem.transitional_CM	2.03e-04	Nonsignificant	0.96	0.78	Other	31	20
626	T.CD4_Tcm.synapse_dynamics	2.03e-04	Nonsignificant	0.95	0.90	Other	15	10
627	IPSC.mesendo_primed	1.85e-04	Nonsignificant	1.00	0.92	Other	0	0
628	B.memory.pDC_imprint	1.84e-04	Nonsignificant	1.00	0.59	Other	157	103
629	EPI.lung_multiciliated.stress	1.82e-04	Nonsignificant	—	0.00	Other	67	165
630	EPI.pancreatic_ductal_bicarbonate.activated	1.81e-04	Nonsignificant	0.97	0.73	Other	10	7
631	T.CD8_Tcm.NK_like	1.77e-04	Nonsignificant	0.69	1.09	Other	334	581
632	T.CD4_naive.neddylation	1.75e-04	Nonsignificant	0.99	0.96	Other	104	222
633	T.CD4_Treg.Tr1_like	1.70e-04	Nonsignificant	—	0.00	Other	8	8
634	T.CD4_naive.neddylation_mitoprot	1.58e-04	Nonsignificant	0.99	0.95	Other	93	56
635	EPI.colonocyte.secretory_boost	1.41e-04	Nonsignificant	0.96	0.45	Other	98	91
636	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.16e-04	Nonsignificant	0.97	0.74	Other	40	191
637	T.CD8_naive.baseline	1.16e-04	Nonsignificant	0.92	0.90	Other	142	2
638	T.CD8_Tcm.baseline	1.15e-04	Nonsignificant	0.69	1.08	Other	90	89
639	EPI.pancreatic_acinar.metabolic_onecarbon	1.04e-04	Nonsignificant	0.98	0.97	Other	287	328
640	T.CD4_naive.survival_mitoprot	9.65e-05	Nonsignificant	0.99	1.01	Other	13	7
641	T.CD8_Tcm.helper_like	7.67e-05	Nonsignificant	0.78	0.99	Other	81	159
642	IPSC.axial_identity_primed	7.59e-05	Nonsignificant	1.00	0.73	Other	0	0
643	T.CD8_naive.lipid_synthesis	6.81e-05	Nonsignificant	0.86	1.14	Other	6	4
644	T.CD4_Tcm.RNA_control	6.14e-05	Nonsignificant	0.97	0.85	Other	96	4
645	NEU.INH_VIP.excitatory_coupled	6.08e-05	Nonsignificant	—	0.15	Other	13	0
646	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	5.18e-05	Nonsignificant	—	0.43	Other	0	0
647	THYMO.SP_CD4_naive	4.95e-05	Nonsignificant	1.00	0.88	Other	65	75
648	T.CD4_naive.survival_neddylation	4.82e-05	Nonsignificant	0.99	0.94	Other	26	38
649	EPI.pancreatic_ductal_progenitor.ADM_like	4.64e-05	Nonsignificant	—	0.40	Other	0	0
650	EPI.bile_duct_cholangiocyte.inflammatory_APC	4.54e-05	Nonsignificant	—	0.00	Other	2	0
651	T.CD4_naive.purinergic	4.33e-05	Nonsignificant	0.99	0.95	Other	49	1
652	NEU.INH_VIP.cannabinoid	4.31e-05	Nonsignificant	—	0.00	Other	0	0
653	EPI.pancreatic_ductal_progenitor.baseline	3.70e-05	Nonsignificant	0.19	1.24	Other	179	702
654	T.CD8_naive.mito_proteostasis	2.90e-05	Nonsignificant	0.92	0.92	Other	428	100
655	T.gamma_delta.central_memory	2.73e-05	Nonsignificant	1.00	0.54	Other	460	919
656	NEU.INH_VIP.canonical_disinhibitory	2.51e-05	Nonsignificant	0.89	0.60	Other	59	38
657	T.MAIT.MAPK_brake	2.21e-05	Nonsignificant	0.79	0.93	Other	44	66
658	EPI.bile_duct_cholangiocyte.secretory_mucin	1.90e-05	Nonsignificant	—	0.22	Other	7	12
659	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	1.78e-05	Nonsignificant	—	0.00	Other	0	0
660	T.CD8_naive.effector_transition	1.72e-05	Nonsignificant	0.92	0.88	Other	35	62
661	NEU.EXC_IT.adhesion	1.70e-05	Nonsignificant	1.00	0.31	Other	252	108
662	T.CD4_cytotoxic.precursor	1.68e-05	Nonsignificant	1.00	0.05	Other	156	67
663	T.MAIT.quiescent	1.61e-05	Nonsignificant	0.79	0.98	Other	100	5
664	ASTRO.homeostatic	1.17e-05	Nonsignificant	1.00	0.35	Other	200	431
665	OLG.myelinating_stress	1.16e-05	Nonsignificant	0.94	1.06	Other	232	62
666	NEU.INH_VIP.nuclear_reg	1.08e-05	Nonsignificant	—	0.00	Other	20	4
667	NEU.INH_VIP.opioid	9.51e-06	Nonsignificant	—	0.00	Other	50	9
668	T.CD8_naive.innate_like	9.17e-06	Nonsignificant	0.92	0.72	Other	10	1
669	THYMO.SP_CD8_naive	8.94e-06	Nonsignificant	1.00	0.50	Other	297	177
670	T.MAIT.vesicle	8.67e-06	Nonsignificant	0.79	0.89	Other	37	65
671	T.CD4_naive.proteostasis	7.48e-06	Nonsignificant	0.99	0.85	Other	14	9
672	T.CD4_naive.gut_prone	5.69e-06	Nonsignificant	0.99	0.84	Other	35	70
673	EPI.pancreatic_ductal_progenitor.ciliated_transport	5.48e-06	Nonsignificant	—	0.00	Other	105	368
674	T.MAIT.cytotoxic	4.33e-06	Nonsignificant	0.79	0.92	Other	52	15
675	THYMO.proliferative_G2M	4.09e-06	Nonsignificant	—	0.00	Other	164	413
676	EPI.pancreatic_acinar.adhesion_remodeling	3.97e-06	Nonsignificant	0.98	0.63	Other	210	784
677	EPI.pancreatic_acinar.baseline	3.81e-06	Nonsignificant	0.98	0.59	Other	274	163
678	T.CD8_Tcm.effector_bias	3.00e-06	Nonsignificant	0.92	0.80	Other	199	329
679	T.CD4_naive.proteostasis_mitoprot	2.34e-06	Nonsignificant	0.99	0.65	Other	15	37
680	T.MAIT.stress	2.08e-06	Nonsignificant	—	0.00	Other	0	0
681	OLG.regulatory	2.03e-06	Nonsignificant	1.00	0.93	Other	353	73
682	THYMO.CD8aa_IELp	1.35e-06	Nonsignificant	—	0.00	Other	1	7
683	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.25e-06	Nonsignificant	—	0.00	Other	0	0
684	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	2.46e-07	Nonsignificant	—	0.00	Other	49	237
685	NEU.EXC_CT.Ca2_sensor	6.61e-08	Nonsignificant	—	0.00	Other	0	0
686	EPI.renal_distal_tubule.immune_modulatory	6.59e-08	Nonsignificant	—	0.00	Other	0	0
687	OLG.vesicle_trafficking	1.65e-08	Nonsignificant	1.00	0.70	Other	124	10
688	OLG.reactive_repair	5.08e-11	Nonsignificant	1.00	0.17	Other	385	385

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

72 unique genes. Showing 1–72. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
SLC22A4	01-High	0.72	11.61	G1	C1	—	MAC.alveolar.capillary_interacting (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	31 cells — complete matches	289	399
GPR84	01-High	0.68	10.05	G1	C1	—	dendritic_cell (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.MDM (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	43 cells — complete matches	141	177
ZNF385A	01-High	0.65	8.44	G1	C1	FIB.neurolectin_mucosa.nerve_interface (L2)	dendritic_cell (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14.APC_like (Tier: specific) DC.mig (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	51 cells — complete matches	94	96
IRF1	01-High	0.60	10.92	G1	C1	EC.arterial.inflammatory (L2), EPI.renal_principal_cell.activated_acute (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), FIB.hepatic_stellate_cell.inflammatory (L2), FIB.interstitial.immune_interact (L2), FIB.neurolectin_mucosa.inflammatory (L2), HEP.acute_phase.inflammatory (L2), PC.IgA_muocsal.plasmablast (L2)	ADIPO.inflammatory (Tier: relevant)	25 cells — complete matches	618	847
SLC22A5	02-Medium	0.68	13.22	G1	C2	—	—	13 cells — complete matches	376	507
MIR3936HG	02-Medium	0.68	13.43	G1	C2	—	—	—	302	416
P4HA2	02-Medium	0.68	13.28	G1	C2	—	MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.repair_M2_like (Tier: relevant)	14 cells — complete matches	213	354
CARINH	02-Medium	0.60	13.03	G1	C2	—	—	—	411	545
ENSG00000283782	02-Medium	0.60	13.42	G1	C2	—	—	—	374	500
LONP1	02-Medium	0.58	8.27	G1	C2	EC.liver_sinusoidal.hypoxia_metabolic (L2)	—	14 cells — complete matches	0	0
PDLIM4	02-Medium	0.57	12.46	G2	C2	EPI.salivary_intercalated_defense.inflammatory (L2)	skeletal_muscle_cell (Tier: specific) EC.lymphatic (Tier: specific) MAC.LAM (Tier: specific) SKM.type_2_fast (Tier: specific) GRNLSA.secretory_remodeling (Tier: specific) EC.lymphatic.activated (Tier: relevant) EC.lymphatic.tip_migratory (Tier: relevant) FIB.transitioning.ISG_primed_interface (Tier: relevant) FIB.transitioning.motility_remodelling (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant)	70 cells — complete matches	171	263
LINC02863	02-Medium	0.57	11.99	G1	C2	—	—	—	360	492
NFE2	02-Medium	0.56	10.09	G2	C1	PLAT.megakaryocytic (L2)	dendritic_cell (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MONO.CD14 (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) platelet (Tier: relevant) HPC.haematopoietic_progenitor_cell (Tier: relevant) PLAT.platelet (Tier: relevant) HPC.MEP (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.proliferating.stress (Tier: relevant) PLAT.adhesion (Tier: relevant)	40 cells — complete matches	7	9
ENSG00000298170	02-Medium	0.55	11.23	G1	C2	—	—	—	353	447
CATSPERD	02-Medium	0.54	8.57	G1	C2	—	—	12 cells — complete matches	14	13
HNRNPA1	02-Medium	0.53	9.69	G1	C2	EPI.tracheal_suprabasal.transitional_wound (L2)	—	—	13	14
ENSG00000303642	02-Medium	0.53	10.65	G2	C1	—	—	—	4	4
JMJD1C	02-Medium	0.52	8.28	G1	C2	—	EC.liver_sinusoidal.prostanoid (Tier: relevant)	4 cells — complete matches	290	935
GP6	02-Medium	0.50	8.33	G2	C2	—	MONO.CD14.APC_like (Tier: specific) MONO.CD16.platelet_bound (Tier: specific) platelet (Tier: relevant) PLAT.platelet (Tier: relevant) FIB.transitioning.motility_remodelling (Tier: relevant) PLAT.adhesion (Tier: relevant)	12 cells — complete matches	1	1
ENSG00000307127	02-Medium	0.49	8.61	G1	C2	—	—	—	182	667
ENSG00000289154	02-Medium	0.48	11.03	G2	C2	—	—	—	0	0
RPL36	02-Medium	0.48	6.81	G1	C2	SCHWN.translation_boost (L2)	EC.lymphatic.activated (Tier: relevant) EC.lymphatic.baseline (Tier: relevant) EC.lymphatic.tip_migratory (Tier: relevant)	51 cells — complete matches	1	11
LINC02356	02-Medium	0.46	3.05	G1	C2	—	dendritic_cell (Tier: specific) DC.cDC2 (Tier: specific) MAC.proliferating (Tier: relevant) DC.cDC1.homeostatic_inhibitory (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	28 cells — complete matches	263	733
RDH13	02-Medium	0.46	9.03	G2	C2	—	—	9 cells — complete matches	2	2
PHETA1	02-Medium	0.46	2.90	G1	C2	—	—	—	228	664
ENSG00000267149	02-Medium	0.46	8.85	G2	C2	—	—	—	1	1
ENSG00000289854	02-Medium	0.46	11.14	G2	C2	—	—	—	1	1
ENSG00000307521	02-Medium	0.46	8.79	G2	C2	—	—	—	16	21
REEP3	02-Medium	0.46	9.81	G2	C2	—	GRANU.neutrophil.tissue_patrolling (Tier: relevant)	5 cells — complete matches	132	589
GP6-AS1	02-Medium	0.45	7.63	G2	C2	—	—	—	4	4
ENSG00000286373	02-Medium	0.45	8.85	G2	C1	—	—	—	18	26
MIR3936	02-Medium	0.45	9.81	G2	C2	—	—	—	0	0
CBX5	02-Medium	0.45	9.30	G2	C2	—	—	FIB.adventitial.mechano_chemo_sensing (L2)	1	1
SH2B3	02-Medium	0.44	2.93	G1	C2	—	MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) DC.cDC1.homeostatic_inhibitory (Tier: relevant) GRANU.neutrophil.tissue_patrolling (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant)	47 cells — complete matches	316	770
RAD50	02-Medium	0.43	6.48	G1	C2	—	—	T.CD4_Tcm.secretory (L2), T.CD4_cytotoxic.terminal_effector (L2)	197	287
ENSG00000224015	02-Medium	0.43	9.53	G2	C2	—	—	—	6	28
ATXN2	02-Medium	0.42	2.35	G1	C2	—	—	7 cells — complete matches	48	83
ACSL6	02-Medium	0.41	6.11	G2	C2	—	—	59 cells — complete matches	5	2
ENSG00000281938	02-Medium	0.41	6.01	G2	C2	—	—	—	5	2
ENSG00000228566	02-Medium	0.40	6.44	G2	C1	—	—	—	29	77
CSF2	02-Medium	0.40	8.58	G2	C2	—	MAC.LAM (Tier: specific)	54 cells — complete matches	11	34
CUX2	02-Medium	0.39	4.03	G1	C2	NEU.EXC_IT (L1S)	dendritic_cell (Tier: specific)	13 cells — complete matches	207	650
NRBF2	02-Medium	0.38	5.46	G2	C1	—	MONO.CD14.repair_M2_like (Tier: relevant)	FIB.lung_alveolar.mito_secretory (L2), MONO.CD14.repair_M2_like (L2)	2	5
ENSG00000304623	02-Medium	0.38	3.25	G1	C2	—	—	—	219	658
TMCC2	02-Medium	0.37	5.74	G2	C2	—	MAC.resident_repair.lipid_phagocytic (Tier: specific) DC.mig (Tier: relevant)	9 cells — complete matches	3	3
KIF3A	02-Medium	0.37	4.71	G1	C2	—	—	14 cells — complete matches	132	203
ENSG00000258344	02-Medium	0.36	11.45	G2	C2	—	—	—	4	12
ENSG00000294281	02-Medium	0.36	2.71	G1	C2	—	—	—	156	504
ENSG00000299832	02-Medium	0.36	2.71	G1	C2	—	—	—	156	504
EPS8L1	02-Medium	0.36	8.20	G2	C2	—	—	44 cells — complete matches	1	1
SCAT2	02-Medium	0.36	9.30	G2	C2	—	—	—	0	0
SEPTIN8	02-Medium	0.34	3.73	G1	C2	—	—	—	109	187
EGR2	02-Medium	0.33	4.59	G2	C1	IPSC.neural_primed (L2)	MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) MONO.CD14.repair_M2_like (Tier: relevant)	54 cells — complete matches	3	8
PPP1R12C	02-Medium	0.33	7.76	G2	C2	—	—	14 cells — complete matches	0	0
ENSG00000243797	02-Medium	0.32	7.02	G2	C2	—	—	—	2	5
ENSG00000289487	02-Medium	0.31	4.22	G2	C1	—	—	—	1	1
RBBP5	02-Medium	0.31	5.85	G2	C2	—	—	B.naive.proteostasis (L2), B.naive.remodeling (L2)	5	9
MEIKIN	02-Medium	0.30	5.77	G2	C2	—	dendritic_cell (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) MONO.CD16.platelet_bound (Tier: specific) DC.mig (Tier: relevant) MAC.MDM (Tier: relevant) MAC.proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	48 cells — complete matches	7	26
FCAR	02-Medium	0.30	5.76	G2	C2	MAC.MDM.inflammatory_phagocytic (L2)	monocyte (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.MDM (Tier: relevant) GRANU.neutrophil.tissue_patrolling (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	29 cells — complete matches	13	17
NLRP2	02-Medium	0.29	7.76	G2	C2	—	DC.cDC2.proliferative (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant)	25 cells — complete matches	9	10
DSTYK	02-Medium	0.28	6.16	G2	C2	—	FIB.transitioning.motility_remodelling (Tier: relevant)	23 cells — complete matches	3	3
PDIA5	02-Medium	0.27	5.87	G2	C2	—	—	25 cells — complete matches	2	3
ENSG00000285837	02-Medium	0.26	1.48	G2	C1	—	—	—	23	30
LINC02929	02-Medium	0.26	1.82	G2	C1	—	—	—	3	5
RPL36AP50	02-Medium	0.26	6.54	G2	C2	—	—	—	0	0
KIR3DL1	02-Medium	0.26	6.35	G2	C2	T.CD8_Tem.TEMRA (L2)	—	36 cells — complete matches	4	6
ADO	02-Medium	0.25	4.08	G2	C2	—	DC.cDC2.proliferative (Tier: relevant)	16 cells — complete matches	10	26
KIR2DL1	02-Medium	0.25	6.96	G2	C2	T.CD8_Tem.TEMRA (L2)	—	26 cells — complete matches	8	10
KIR2DS4	02-Medium	0.21	3.64	G2	C2	—	—	—	1	1
LAIR2	02-Medium	0.18	2.62	G2	C2	T.CD4_naive.Treg_like (L2), T.gamma_delta.cytotoxic_effector (L2)	dendritic_cell (Tier: specific) MONO.CD16.platelet_bound (Tier: specific)	91 cells — complete matches	6	8
LILRB4	02-Medium	0.17	2.06	G2	C2	—	dendritic_cell (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) MONO.CD16.platelet_bound (Tier: specific) MAC.MDM (Tier: relevant) MAC.proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	75 cells — complete matches	14	16
LILRB1	02-Medium	0.16	2.36	G2	C2	monocyte (L1), MONO.CD14 (L1S), MONO.CD16 (L1S), MONO.CD16.baseline (L2), NK.adaptive_classII_inhibitory (L2)	dendritic_cell (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MONO.CD16.platelet_bound (Tier: specific) MAC.MDM (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	91 cells — complete matches	17	21

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.