Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90468898 · All tissues

CSTB levels: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: CSTB levels

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	skeletal_muscle_cell	24.51	Significant	3.30e-49	1.72	Specific	944	2,600
2	haematopoietic_progenitor_cell	10.29	Significant	8.89e-06	1.51	Specific	262	502
3	platelet	7.31	Significant	—	1.80	Relevant	85	104
4	thymocyte	4.22	Nominal	7.86e-07	1.33	Other	168	512
5	monocyte	3.28	Nominal	2.08e-37	1.34	Other	2,176	3,871
6	cardiomyocyte	3.21	Nominal	1.92e-12	1.31	Other	533	2,045
7	innate_lymphoid_cell_2	2.39	Nonsignificant	1.00	1.12	Other	3	8
8	macrophage	2.38	Nonsignificant	0.12	1.08	Other	813	1,732
9	dendritic_cell	2.20	Nonsignificant	0.66	1.07	Other	496	724
10	endothelial_cell	2.04	Nonsignificant	0.02	1.09	Other	373	974
11	pericyte	1.75	Nonsignificant	1.00	0.93	Other	128	517
12	hepatocyte	1.65	Nonsignificant	1.00	1.00	Other	1,515	3,822
13	plasma_cell	1.56	Nonsignificant	1.00	0.98	Other	17	24
14	B_cell	1.25	Nonsignificant	1.00	0.96	Other	356	694
15	microglia	1.06	Nonsignificant	1.00	0.74	Other	61	129
16	oligodendrocyte	1.03	Nonsignificant	1.00	0.82	Other	385	1,507
17	mesothelial_cell	0.89	Nonsignificant	1.00	0.88	Other	6	36
18	granulocyte	0.87	Nonsignificant	1.00	0.76	Other	5	6
19	oligodendrocyte_precursor_cell	0.85	Nonsignificant	1.00	0.77	Other	461	1,454
20	smooth_muscle_cell	0.79	Nonsignificant	1.00	0.75	Other	27	139
21	T_cell	0.57	Nonsignificant	1.00	0.61	Other	470	959
22	melanocyte	0.51	Nonsignificant	1.00	0.56	Other	97	309
23	neuron	0.45	Nonsignificant	7.45e-19	1.51	Other	330	1,328
24	epithelial_cell	0.35	Nonsignificant	1.00	0.56	Other	24	47
25	fibroblast	0.23	Nonsignificant	1.00	0.51	Other	184	826
26	natural_killer_cell	0.23	Nonsignificant	1.00	0.42	Other	1,204	2,052
27	muscle_stem_cell	0.16	Nonsignificant	1.00	0.43	Other	7	27
28	chondrocyte	0.05	Nonsignificant	1.00	0.61	Other	548	1,069
29	astrocyte	0.04	Nonsignificant	1.00	0.31	Other	256	1,203
30	granulosa_cell	0.02	Nonsignificant	1.00	0.28	Other	293	670
31	adipose_stem_and_progenitor_cell	0.01	Nonsignificant	1.00	0.46	Other	327	954
32	schwann_cell	1.56e-03	Nonsignificant	1.00	0.25	Other	10	57
33	induced_pluripotent_stem_cell	7.84e-04	Nonsignificant	1.00	0.23	Other	0	0
34	adipocyte	1.23e-04	Nonsignificant	1.00	0.23	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	SKM.type_1_slow	32.75	Significant	1.82e-35	4.38	Specific	923	2,478
2	SKM.type_2_fast	18.39	Significant	1.00	0.00	Specific	972	2,639
3	HPC.haematopoietic_progenitor_cell	10.29	Significant	—	—	Specific	211	370
4	NEU.INH_LAMP5	7.38	Significant	7.19e-05	1.16	Specific	263	532
5	PLAT.platelet	7.31	Significant	—	0.00	Relevant	38	53
6	EC.liver_sinusoidal	5.85	Significant	1.68e-04	1.46	Specific	1,083	1,925
7	THYMO.thymocyte	4.22	Nominal	—	—	Other	163	495
8	EC.lymphatic	4.20	Nominal	1.68e-04	1.44	Other	630	998
9	MAC.resident_repair	3.85	Nominal	9.35e-11	2.14	Other	796	1,426
10	MONO.CD14	3.58	Nominal	4.85e-29	2.62	Other	2,294	4,139
11	MAC.resident_cardiac	3.46	Nominal	2.47e-06	1.79	Other	485	1,074
12	CM.cardiomyocyte	3.21	Nominal	—	—	Other	524	2,032
13	HEP.periportal_metabolic	3.17	Nominal	1.71e-12	1.43	Other	1,750	4,427
14	B.age_associated	2.93	Nonsignificant	4.58e-10	3.09	Other	207	350
15	DC.cDC1	2.83	Nonsignificant	0.18	1.35	Other	55	112
16	MAC.MDM	2.79	Nonsignificant	0.23	1.27	Other	623	986
17	EC.arterial	2.79	Nonsignificant	3.46e-05	1.28	Other	356	885
18	EC.heart_remodeling	2.50	Nonsignificant	0.30	1.07	Other	569	1,594
19	ILC2.innate_lymphoid_cell_2	2.39	Nonsignificant	—	—	Other	2	0
20	DC.cDC2	2.21	Nonsignificant	0.10	1.47	Other	1,189	1,793
21	EC.capillary	2.19	Nonsignificant	1.00	0.94	Other	514	1,635
22	EPI.salivary_mucous_acinar	2.14	Nonsignificant	1.07e-08	1.53	Other	639	1,189
23	MAC.microglia_like	2.11	Nonsignificant	0.79	1.12	Other	124	179
24	GRANU.neutrophil	2.01	Nonsignificant	9.43e-04	1.63	Other	1,235	2,649
25	DC.pDC	1.97	Nonsignificant	0.18	1.30	Other	496	1,028
26	DC.mig	1.90	Nonsignificant	—	0.03	Other	89	156
27	EPI.salivary_intercalated_defense	1.88	Nonsignificant	0.05	1.34	Other	81	161
28	MAC.LAM	1.84	Nonsignificant	1.00	0.46	Other	914	2,064
29	PERI.pericyte	1.75	Nonsignificant	—	—	Other	117	0
30	MONO.CD16	1.73	Nonsignificant	1.00	0.10	Other	1,304	1,835
31	PC.IgG_systemic	1.61	Nonsignificant	0.62	0.89	Other	41	60
32	PC.IgA_muocsal	1.56	Nonsignificant	0.62	1.14	Other	18	31
33	MAC.proliferating	1.49	Nonsignificant	1.00	0.70	Other	87	253
34	EPI.ileal_enterocyte_absorptive	1.41	Nonsignificant	0.05	1.31	Other	118	338
35	MAC.kupffer	1.38	Nonsignificant	1.00	0.22	Other	189	530
36	B.naive	1.28	Nonsignificant	7.81e-03	1.59	Other	307	595
37	HEP.canalicular_transport	1.18	Nonsignificant	1.00	0.96	Other	1,290	3,434
38	B.memory	1.15	Nonsignificant	1.00	0.28	Other	442	882
39	T.CD4_naive	1.12	Nonsignificant	1.60e-49	1.66	Other	399	866
40	MG.microglia	1.06	Nonsignificant	—	—	Other	49	0
41	EPI.skin_keratinocyte_basal	1.06	Nonsignificant	—	1.32	Other	13	26
42	MAC.resident_iron	1.05	Nonsignificant	1.00	0.01	Other	16	21
43	OLG.oligodendrocyte	1.03	Nonsignificant	—	—	Other	384	1,397
44	T.CD8_naive	1.01	Nonsignificant	3.39e-09	1.35	Other	317	708
45	EPI.ectocervical_granular	0.95	Nonsignificant	—	1.01	Other	11	23
46	MAC.alveolar	0.92	Nonsignificant	1.00	0.13	Other	1,432	3,122
47	MESO.mesothelial_cell	0.89	Nonsignificant	—	—	Other	2	18
48	OPC.oligodendrocyte_precursor_cell	0.85	Nonsignificant	—	—	Other	413	1,269
49	SMC.smooth_muscle_cell	0.79	Nonsignificant	—	—	Other	20	101
50	EPI.salivary_myoepithelial	0.68	Nonsignificant	0.05	1.27	Other	191	714
51	EPI.bile_duct_cholangiocyte	0.64	Nonsignificant	1.00	1.17	Other	37	60
52	EPI.skin_follicular_keratinizing	0.59	Nonsignificant	0.73	1.22	Other	30	81
53	FIB.hepatic_stellate_cell	0.58	Nonsignificant	—	1.28	Other	64	252
54	EPI.skin_keratinocyte_progenitor	0.53	Nonsignificant	—	0.89	Other	0	3
55	MEL.melanocyte	0.51	Nonsignificant	—	—	Other	79	242
56	EPI.tracheal_submucosal_gland	0.48	Nonsignificant	—	0.69	Other	0	0
57	T.CD4_Trm	0.47	Nonsignificant	1.00	0.95	Other	176	363
58	T.CD4_Tcm	0.46	Nonsignificant	1.00	0.80	Other	494	988
59	FIB.adventitial	0.44	Nonsignificant	8.68e-23	1.50	Other	268	1,447
60	EPI.salivary_duct_excretory	0.44	Nonsignificant	1.00	0.99	Other	85	180
61	EPI.pancreatic_acinar	0.43	Nonsignificant	1.00	0.97	Other	429	1,475
62	EPI.ileal_enterocyte_crypt	0.42	Nonsignificant	1.00	0.97	Other	67	113
63	EPI.salivary_duct_ion_transport	0.42	Nonsignificant	1.00	0.98	Other	5	11
64	EPI.salivary_serous_acinar	0.41	Nonsignificant	0.01	1.21	Other	233	531
65	EPI.skin_sebaceous_duct_luminal	0.38	Nonsignificant	1.00	1.09	Other	100	249
66	EPI.esophageal_suprabasal	0.38	Nonsignificant	1.00	0.83	Other	158	404
67	T.CD8_Tcm	0.38	Nonsignificant	1.00	0.66	Other	460	926
68	EC.venous	0.37	Nonsignificant	1.00	0.03	Other	516	1,387
69	T.CD8_Trm	0.35	Nonsignificant	1.00	0.70	Other	211	346
70	EPI.gastric_foveolar	0.32	Nonsignificant	—	0.55	Other	0	0
71	T.CD4_Tem	0.31	Nonsignificant	1.00	0.58	Other	365	697
72	EPI.ileal_bile_transport	0.31	Nonsignificant	1.00	0.98	Other	61	93
73	EPI.renal_proximal_tubule	0.30	Nonsignificant	1.00	0.98	Other	525	806
74	T.CD4_Tfh	0.30	Nonsignificant	1.00	0.60	Other	47	45
75	B.germinal_center	0.29	Nonsignificant	1.00	0.00	Other	233	655
76	EPI.skin_interfollicular_spinous	0.28	Nonsignificant	1.00	0.78	Other	260	563
77	EPI.skin_sweat_duct_keratinocyte	0.27	Nonsignificant	1.00	0.76	Other	146	301
78	EPI.thymic_medullary	0.27	Nonsignificant	1.00	0.92	Other	26	133
79	EPI.skin_keratinocyte_proliferating	0.26	Nonsignificant	1.00	0.84	Other	47	76
80	NK.natural_killer_cell	0.23	Nonsignificant	—	—	Other	1,204	2,045
81	T.CD8_transitional	0.23	Nonsignificant	1.00	0.38	Other	497	932
82	T.CD4_Th17	0.22	Nonsignificant	1.00	0.49	Other	421	794
83	NEU.INH_PVALB	0.22	Nonsignificant	1.00	0.99	Other	193	183
84	EPI.cervical_suprabasal	0.22	Nonsignificant	—	0.30	Other	14	50
85	HEP.acute_phase	0.21	Nonsignificant	1.00	0.28	Other	1,441	3,641
86	GRANU.MAST	0.21	Nonsignificant	1.00	0.00	Other	5	6
87	EPI.esophageal_basal	0.21	Nonsignificant	1.00	0.73	Other	4	10
88	EPI.tracheal_basal	0.20	Nonsignificant	1.00	0.80	Other	398	1,120
89	T.gamma_delta	0.20	Nonsignificant	1.00	0.34	Other	588	1,078
90	FIB.lung_alveolar	0.16	Nonsignificant	—	0.34	Other	6	15
91	MUSC.muscle_stem_cell	0.16	Nonsignificant	—	—	Other	4	18
92	T.CD4_transitional	0.14	Nonsignificant	1.00	0.33	Other	48	110
93	FIB.reticular	0.13	Nonsignificant	1.00	0.73	Other	19	87
94	EPI.alveolar_type_2	0.13	Nonsignificant	1.00	0.76	Other	813	1,853
95	EPI.renal_intercalated_cell_type_B	0.13	Nonsignificant	—	0.08	Other	6	7
96	T.MAIT	0.12	Nonsignificant	1.00	0.33	Other	469	855
97	FIB.barrier_purinergic	0.12	Nonsignificant	—	0.18	Other	1	3
98	EPI.skin_appendage_keratinocyte	0.11	Nonsignificant	1.00	0.70	Other	87	222
99	EPI.lung_club_secretory	0.11	Nonsignificant	1.00	0.70	Other	5	14
100	EPI.tracheal_suprabasal	0.10	Nonsignificant	1.00	0.72	Other	29	56
101	T.CD4_cytotoxic	0.07	Nonsignificant	1.00	0.11	Other	855	1,493
102	NEU.EXC_CT	0.07	Nonsignificant	1.00	0.89	Other	362	384
103	EPI.endocervical_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
104	EPI.renal_intercalated_cell_type_A	0.06	Nonsignificant	1.00	0.72	Other	67	142
105	T.CD4_Th2	0.06	Nonsignificant	—	0.00	Other	1	2
106	EPI.extrahepatic_cholangiocyte	0.05	Nonsignificant	—	0.00	Other	37	71
107	CHOND.chondrocyte	0.05	Nonsignificant	—	—	Other	519	730
108	FIB.perivascular_interface	0.04	Nonsignificant	1.00	0.57	Other	0	0
109	T.CD8_Tem	0.04	Nonsignificant	1.00	0.03	Other	1,083	1,857
110	ASTRO.astrocyte	0.04	Nonsignificant	—	—	Other	228	1,111
111	T.CD4_Treg	0.04	Nonsignificant	1.00	0.04	Other	244	511
112	EPI.thymic_cortical	0.03	Nonsignificant	1.00	0.64	Other	442	824
113	EPI.colonic_enteroendocrine	0.03	Nonsignificant	—	0.00	Other	1	1
114	FIB.interstitial	0.03	Nonsignificant	1.00	0.37	Other	288	940
115	GRNLSA.granulosa_cell	0.02	Nonsignificant	—	—	Other	257	0
116	NEU.INH_VIP	0.02	Nonsignificant	1.00	0.83	Other	241	366
117	FIB.skin_neurosecretory	0.02	Nonsignificant	—	0.00	Other	0	0
118	EPI.pancreatic_islet	0.01	Nonsignificant	1.00	0.59	Other	52	132
119	ASPC.adipose_stem_and_progenitor_cell	0.01	Nonsignificant	—	—	Other	324	930
120	EPI.renal_immature_ureteric_bud	0.01	Nonsignificant	1.00	0.59	Other	217	569
121	HEP.pericentral_lipoprotein	9.35e-03	Nonsignificant	—	0.00	Other	0	0
122	NEU.EXC_SYT2	7.29e-03	Nonsignificant	—	0.17	Other	40	77
123	EPI.renal_distal_tubule	6.26e-03	Nonsignificant	1.00	0.62	Other	133	361
124	EPI.colonic_tuft	5.56e-03	Nonsignificant	—	0.00	Other	7	24
125	EPI.skin_hair_follicle_bulge	5.27e-03	Nonsignificant	1.00	0.59	Other	51	178
126	EPI.ileal_goblet	5.03e-03	Nonsignificant	1.00	0.75	Other	181	432
127	EPI.alveolar_type_1	4.28e-03	Nonsignificant	1.00	0.44	Other	26	101
128	EPI.renal_principal_cell	3.24e-03	Nonsignificant	1.00	0.50	Other	207	403
129	EPI.renal_thick_ascending_limb	2.15e-03	Nonsignificant	1.00	0.43	Other	453	1,153
130	NEU.EXC_IT	2.11e-03	Nonsignificant	1.00	0.87	Other	411	192
131	SCHWN.schwann_cell	1.56e-03	Nonsignificant	—	—	Other	7	33
132	FIB.skin_sheath	1.19e-03	Nonsignificant	1.00	0.54	Other	49	118
133	FIB.tracheal_subepithelial	1.14e-03	Nonsignificant	—	0.00	Other	0	0
134	EPI.colonocyte	9.76e-04	Nonsignificant	1.00	0.51	Other	294	815
135	FIB.suburothelial	8.42e-04	Nonsignificant	1.00	0.30	Other	122	432
136	IPSC.induced_pluripotent_stem_cell	7.84e-04	Nonsignificant	—	—	Other	0	0
137	EPI.lung_multiciliated	6.44e-04	Nonsignificant	1.00	0.43	Other	16	49
138	FIB.barrier_secretory	5.81e-04	Nonsignificant	1.00	0.44	Other	81	228
139	FIB.transitioning	5.57e-04	Nonsignificant	1.00	0.41	Other	172	497
140	EPI.skin_hair_follicle_companion	1.99e-04	Nonsignificant	—	0.00	Other	8	12
141	EPI.pancreatic_ductal_perivascular	1.47e-04	Nonsignificant	1.00	0.38	Other	4	30
142	ADIPO.adipocyte	1.23e-04	Nonsignificant	—	—	Other	20	62
143	FIB.neurolectin_mucosa	9.37e-05	Nonsignificant	1.00	0.27	Other	133	394
144	FIB.skin_tenogenic	8.38e-05	Nonsignificant	—	0.00	Other	108	227
145	EPI.pancreatic_ductal_progenitor	5.68e-05	Nonsignificant	1.00	0.42	Other	234	873
146	EPI.intrahepatic_cholangiocyte_defense	7.32e-06	Nonsignificant	—	0.00	Other	8	13
147	EPI.pancreatic_ductal_bicarbonate	3.51e-06	Nonsignificant	1.00	0.29	Other	131	548
148	FIB.skin_papillary	2.15e-07	Nonsignificant	—	0.00	Other	0	0
149	EPI.hepatic_ductular_cholangiocyte	2.14e-07	Nonsignificant	1.00	0.27	Other	83	243
150	EPI.intrahepatic_cholangiocyte_transport	2.63e-08	Nonsignificant	—	0.00	Other	12	42
151	EPI.pancreatic_ductal_mucinous	4.66e-11	Nonsignificant	1.00	0.05	Other	219	430
152	NEU.EXC_NTNG1	1.44e-13	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	SKM.type_1_slow.oxidative	33.33	Significant	0.27	1.63	—	802	251
2	SKM.type_1_slow.glycolytic	32.64	Significant	0.49	1.21	Specific	362	647
3	SKM.type_1_slow.contractile	32.38	Significant	0.56	0.92	—	596	8
4	SKM.type_2_fast.oxidative_IIa	19.16	Significant	0.03	1.92	—	946	56
5	SKM.type_2_fast.glycolytic_IIx_IIb	17.10	Significant	0.91	0.50	Specific	565	1,482
6	HPC.MPP_IEG	16.47	Significant	0.54	1.36	—	45	46
7	HPC.MPP_activated	13.54	Significant	—	0.46	—	0	0
8	HPC.MEP	12.90	Significant	0.62	1.03	Relevant	599	1,195
9	PLAT.megakaryocytic	10.36	Significant	—	0.97	—	0	0
10	HPC.LMPP	9.84	Significant	0.62	1.11	—	65	31
11	NEU.INH_LAMP5.glial_interface	9.63	Significant	—	1.16	Relevant	0	0
12	EC.liver_sinusoidal.inflammatory	8.31	Significant	—	1.13	—	223	154
13	NEU.INH_LAMP5.rosehip	8.19	Significant	—	0.58	Relevant	0	0
14	THYMO.SP_CD4_naive	7.81	Significant	0.01	1.76	Specific	65	75
15	HPC.GMP_inflammatory	7.20	Significant	0.85	0.70	—	20	10
16	DC.cDC1.homeostatic_inhibitory	6.88	Significant	—	1.21	Relevant	0	0
17	THYMO.DP_early	6.87	Significant	1.17e-12	2.32	Specific	326	313
18	EC.liver_sinusoidal.stress	6.87	Significant	—	0.68	—	413	158
19	NEU.INH_LAMP5.exc_inh_balance	6.53	Significant	—	0.00	—	46	2
20	EC.lymphatic.scavenger	6.49	Significant	0.36	1.19	Relevant	203	257
21	THYMO.DP_early_stress	6.35	Significant	—	0.80	Relevant	0	0
22	EC.liver_sinusoidal.secretory_lipoprotein	6.31	Significant	0.59	1.22	—	120	70
23	NEU.INH_LAMP5.projecting	6.18	Significant	—	0.00	—	0	0
24	EC.liver_sinusoidal.remodeling_lipotoxicity	6.13	Significant	—	0.03	—	90	58
25	EC.lymphatic.valve	6.00	Significant	—	0.34	Relevant	0	0
26	HEP.periportal_metabolic.canonical_urea_cycle	5.74	Significant	1.34e-05	1.48	Other	1,464	269
27	MONO.CD14.platelet_bound	5.63	Significant	1.18e-05	2.31	Other	964	176
28	PLAT.adhesion	5.54	Significant	—	0.00	Relevant	0	0
29	MONO.CD14.inflammatory	5.06	Nominal	0.01	1.96	Other	92	134
30	EC.liver_sinusoidal.prostanoid	5.01	Nominal	—	0.00	Other	11	64
31	EC.heart_remodeling.activated_acute	4.97	Nominal	0.20	1.43	Other	102	186
32	EC.lymphatic.baseline	4.94	Nominal	4.16e-03	1.71	Other	38	72
33	EC.arterial.arteriole_gas_exchange	4.47	Nominal	7.62e-03	1.36	Other	238	131
34	MONO.CD14.repair_M2_like	4.43	Nominal	0.16	1.38	Other	550	1,495
35	THYMO.SP_CD8_transitional	4.42	Nominal	0.64	1.23	Other	32	75
36	DC.cDC2.monocyte_like	4.40	Nominal	3.49e-04	2.04	Other	1,285	791
37	EC.heart_remodeling.capillary_metabolic	4.24	Nominal	0.13	1.56	Other	54	414
38	MAC.resident_repair.antigen_presenting	4.24	Nominal	0.50	1.42	Other	244	113
39	CM.translation_boost_RPS	4.22	Nominal	0.43	1.34	Other	69	16
40	EC.capillary.inflammatory	4.12	Nominal	0.12	1.39	Other	27	51
41	CM.mechano_activated	4.07	Nominal	0.27	1.53	Other	205	134
42	HEP.periportal_metabolic.xenobiotic_detox	4.06	Nominal	0.09	1.22	Other	1,440	139
43	EC.liver_sinusoidal.hypoxia_metabolic	4.05	Nominal	1.00	0.05	Other	183	107
44	CM.oxidative_phospho	4.04	Nominal	0.05	1.69	Other	266	792
45	HPC.GMP_granulocytic	3.98	Nominal	—	0.00	Other	3	3
46	MAC.resident_repair.chemokine_angiocrine	3.98	Nominal	0.75	0.97	Other	87	138
47	EC.arterial.angiogenic_tip	3.86	Nominal	—	0.47	Other	30	37
48	MAC.resident_repair.ECM_stromal_crosstalk	3.82	Nominal	0.75	0.88	Other	95	158
49	MAC.resident_cardiac.inflammatory_reparative	3.78	Nominal	0.37	1.16	Other	31	96
50	EPI.salivary_serous_acinar.quiescent	3.77	Nominal	3.56e-04	1.37	Other	178	493
51	MONO.CD14.APC_like	3.70	Nominal	0.76	0.91	Other	1,686	2,493
52	MONO.CD14.remodeling	3.66	Nominal	0.29	1.13	Other	2,373	295
53	MAC.resident_cardiac.phagocytic_homeostasis	3.64	Nominal	0.11	1.65	Other	564	1,221
54	MAC.resident_repair.stress_iron	3.64	Nominal	0.50	1.41	Other	48	97
55	HEP.periportal_metabolic.stress_chaperone	3.61	Nominal	—	0.00	Other	66	128
56	HEP.periportal_metabolic.urea_onecarbon_secretory	3.57	Nominal	0.83	1.05	Other	1,332	3,053
57	MAC.MDM.complement_resolving	3.53	Nominal	0.04	1.82	Other	440	860
58	MONO.CD14.baseline	3.50	Nominal	0.99	0.70	Other	2,268	76
59	EC.arterial.inflammatory	3.44	Nominal	7.62e-03	1.49	Other	63	50
60	CM.mito_proteostasis	3.43	Nominal	0.80	0.96	Other	329	29
61	EC.capillary.activated	3.38	Nominal	0.12	1.56	Other	2	5
62	EC.arterial.mito_contact	3.37	Nominal	0.28	1.24	Other	14	5
63	EC.arterial.ion_pump	3.36	Nominal	1.00	0.91	Other	3	2
64	CM.translation_boost_RPL	3.30	Nominal	0.69	1.04	Other	129	1
65	THYMO.DN_preTCR	3.29	Nominal	1.00	0.94	Other	41	71
66	B.age_associated.activated	3.25	Nominal	—	0.46	Other	18	22
67	EC.arterial.arteriole_interface	3.22	Nominal	0.95	1.01	Other	31	12
68	CM.baseline	3.19	Nominal	0.60	1.10	Other	393	0
69	EC.heart_remodeling.angiocrine	3.12	Nominal	3.93e-03	1.68	Other	182	525
70	GRANU.neutrophil.tissue_patrolling	3.05	Nominal	—	0.52	Other	0	0
71	MONO.CD16.platelet_bound	3.02	Nominal	0.30	1.32	Other	372	508
72	MAC.kupffer.metabolic	3.01	Nominal	—	1.32	Other	25	36
73	B.age_associated.naive_transitional	3.00	Nominal	—	0.00	Other	0	0
74	CM.anti_inflammatory	2.98	Nonsignificant	1.00	0.57	Other	424	1,503
75	ILC2.activated	2.98	Nonsignificant	—	0.00	Other	0	0
76	CM.sarcomere_actin_interface	2.96	Nonsignificant	1.00	0.53	Other	450	78
77	EC.capillary.stress	2.88	Nonsignificant	0.73	1.13	Other	44	36
78	EC.lymphatic.tip_migratory	2.78	Nonsignificant	0.85	0.77	Other	23	37
79	MONO.CD16.hepatic_mac_like	2.75	Nonsignificant	2.42e-03	1.79	Other	803	117
80	ILC2.quiescent	2.70	Nonsignificant	—	0.44	Other	0	0
81	THYMO.SP_CD8_naive	2.69	Nonsignificant	1.00	0.44	Other	297	177
82	MAC.MDM.inflammatory_phagocytic	2.68	Nonsignificant	0.84	0.93	Other	199	52
83	EPI.ectocervical_granular.secretory_apocrine	2.67	Nonsignificant	—	1.15	Other	0	0
84	THYMO.CD8aa_IELp	2.66	Nonsignificant	—	0.00	Other	1	7
85	B.age_associated.migratory	2.63	Nonsignificant	0.76	0.67	Other	2	2
86	DC.cDC2.migratory	2.58	Nonsignificant	0.19	1.47	Other	185	39
87	EPI.salivary_intercalated_defense.canonical_antimicrobial	2.57	Nonsignificant	0.13	1.48	Other	11	22
88	EC.heart_remodeling.remodeling_secretory	2.54	Nonsignificant	0.53	1.09	Other	605	1,341
89	EC.venous.cardiac_structural	2.53	Nonsignificant	0.01	1.48	Other	102	229
90	MAC.resident_cardiac.antigen_presenting	2.49	Nonsignificant	0.37	1.13	Other	52	27
91	DC.cDC1.activated	2.45	Nonsignificant	—	0.32	Other	0	0
92	GRANU.neutrophil.antiviral_endotoxin	2.38	Nonsignificant	—	0.64	Other	0	0
93	MONO.CD16.inflammatory	2.37	Nonsignificant	7.20e-04	1.75	Other	1,640	168
94	MAC.resident_repair.lipid_phagocytic	2.35	Nonsignificant	0.99	0.05	Other	228	604
95	PC.IgG_systemic.stress	2.35	Nonsignificant	—	1.08	Other	1	5
96	THYMO.SP_CD8_naive_stress	2.34	Nonsignificant	1.00	0.18	Other	1	1
97	MAC.MDM.LAM_like	2.32	Nonsignificant	0.84	0.87	Other	12	14
98	MAC.microglia_like.phagocytic_redox	2.31	Nonsignificant	—	0.52	Other	0	0
99	MAC.microglia_like.patrolling_adhesive	2.27	Nonsignificant	—	0.69	Other	0	0
100	MAC.LAM.inflammatory_APC	2.27	Nonsignificant	1.25e-05	2.12	Other	872	165
101	MAC.resident_iron.heme_recycling	2.25	Nonsignificant	—	1.32	Other	30	37
102	EC.lymphatic.activated	2.21	Nonsignificant	0.85	0.86	Other	47	73
103	MAC.MDM.APC_dendritic	2.20	Nonsignificant	0.88	0.58	Other	48	15
104	DC.cDC2.proliferative	2.17	Nonsignificant	—	0.00	Other	39	71
105	EPI.salivary_mucous_acinar.baseline	2.14	Nonsignificant	—	—	Other	394	683
106	DC.pDC.baseline	2.11	Nonsignificant	0.40	1.67	Other	88	123
107	HEP.canalicular_transport.ductular_like_transition	2.11	Nonsignificant	5.69e-03	1.55	Other	400	87
108	PERI.cardiac_skeletal	2.10	Nonsignificant	4.75e-05	1.86	Other	313	630
109	DC.cDC2.pro_inflammatory	2.09	Nonsignificant	1.00	0.99	Other	3	5
110	CM.osmoprotection	2.06	Nonsignificant	1.00	0.21	Other	34	57
111	EC.capillary.baseline	2.03	Nonsignificant	1.00	1.00	Other	246	560
112	DC.pDC.immature_metabolic	2.03	Nonsignificant	0.54	1.18	Other	78	124
113	EPI.ileal_enterocyte_absorptive.brush_border	1.93	Nonsignificant	3.06e-04	2.21	Other	580	1,717
114	MAC.microglia_like.inflammatory_chemokine	1.92	Nonsignificant	—	0.00	Other	20	32
115	DC.mig.baseline	1.90	Nonsignificant	—	0.00	Other	1	0
116	PERI.inflammatory	1.90	Nonsignificant	0.57	1.05	Other	40	77
117	DC.cDC1.cross_presenting	1.87	Nonsignificant	—	0.00	Other	0	0
118	MAC.proliferating.stress	1.86	Nonsignificant	—	0.23	Other	87	136
119	HEP.periportal_metabolic.inflammatory_activated	1.84	Nonsignificant	1.00	0.68	Other	712	1,610
120	T.CD4_naive.gut_prone	1.83	Nonsignificant	0.24	1.70	Other	35	70
121	EC.heart_remodeling.translation_boost	1.77	Nonsignificant	—	0.00	Other	0	0
122	MAC.LAM.lipid_opsonization	1.77	Nonsignificant	1.00	1.03	Other	45	14
123	CM.contractile_oxphos	1.76	Nonsignificant	0.27	1.49	Other	6	19
124	DC.pDC.poised_migratory	1.75	Nonsignificant	1.00	0.00	Other	54	95
125	DC.cDC1.proliferative	1.75	Nonsignificant	—	0.00	Other	0	0
126	NK.cytokine_lung_immediate_early	1.74	Nonsignificant	0.02	1.54	Other	424	274
127	EC.arterial.homeostatic	1.72	Nonsignificant	1.00	0.63	Other	24	3
128	PC.IgG_systemic.interacting	1.70	Nonsignificant	0.24	1.61	Other	0	0
129	PC.IgA_muocsal.activated	1.70	Nonsignificant	0.19	1.47	Other	17	8
130	PERI.angiocrine	1.69	Nonsignificant	0.37	1.24	Other	93	102
131	DC.cDC2.adhesion_signaling	1.69	Nonsignificant	1.00	0.62	Other	35	9
132	EPI.salivary_serous_acinar.seromucous_like	1.67	Nonsignificant	—	1.43	Other	0	0
133	FIB.adventitial.adhesion_lipid	1.66	Nonsignificant	2.98e-03	1.73	Other	58	209
134	EPI.skin_keratinocyte_basal.spinous_transition	1.65	Nonsignificant	—	0.97	Other	0	0
135	EC.arterial.metabolic	1.59	Nonsignificant	1.00	0.72	Other	195	159
136	PC.IgA_muocsal.migratory	1.58	Nonsignificant	0.75	1.08	Other	4	1
137	EPI.ectocervical_granular.inflammatory	1.54	Nonsignificant	—	0.32	Other	0	0
138	EC.capillary.migratory	1.54	Nonsignificant	1.00	0.84	Other	181	509
139	T.CD4_naive.proteostasis	1.53	Nonsignificant	0.24	1.48	Other	14	9
140	PC.IgG_systemic.metabolic	1.52	Nonsignificant	0.62	1.09	Other	46	63
141	MAC.kupffer.inflammatory	1.52	Nonsignificant	—	0.05	Other	7	4
142	MAC.LAM.perivascular_angiocrine	1.51	Nonsignificant	—	0.00	Other	53	138
143	HEP.canalicular_transport.pericentral_like_hypoxia	1.50	Nonsignificant	0.27	1.21	Other	326	8
144	PC.IgA_muocsal.plasmablast	1.50	Nonsignificant	0.96	0.77	Other	5	4
145	MAC.LAM.antimicrobial	1.50	Nonsignificant	1.00	0.64	Other	389	93
146	FIB.adventitial.activated_remodelling	1.49	Nonsignificant	—	1.70	Other	141	319
147	DC.cDC2.tolerogenic_regulatory	1.49	Nonsignificant	1.00	0.49	Other	44	4
148	HEP.canalicular_transport.baseline	1.45	Nonsignificant	0.50	1.10	Other	199	477
149	HEP.canalicular_transport.injury_stress	1.45	Nonsignificant	0.21	1.26	Other	289	24
150	MONO.CD16.baseline	1.45	Nonsignificant	0.91	0.84	Other	50	1
151	DC.cDC2.antiviral	1.44	Nonsignificant	1.00	0.25	Other	100	37
152	B.naive.proteostasis	1.43	Nonsignificant	0.78	1.15	Other	49	69
153	ILC2.migratory	1.43	Nonsignificant	—	0.00	Other	0	0
154	THYMO.proliferative_G2M	1.40	Nonsignificant	—	0.00	Other	164	413
155	EC.heart_remodeling.remodeling_stalk	1.40	Nonsignificant	1.00	0.55	Other	33	111
156	EC.capillary.angiocrine	1.39	Nonsignificant	1.00	0.63	Other	250	630
157	B.naive.restrained	1.38	Nonsignificant	0.47	1.40	Other	183	353
158	PC.IgA_muocsal.baseline	1.38	Nonsignificant	0.96	0.54	Other	3	5
159	MG.baseline	1.36	Nonsignificant	0.26	1.36	Other	16	5
160	B.memory.pDC_imprint	1.36	Nonsignificant	0.09	1.86	Other	157	103
161	PC.IgG_systemic.secretory	1.34	Nonsignificant	0.91	0.41	Other	0	0
162	B.naive.purinergic	1.32	Nonsignificant	0.47	1.39	Other	384	820
163	MAC.proliferating.DNA_replication	1.32	Nonsignificant	0.69	0.79	Other	3	6
164	T.CD4_naive.proteostasis_mitoprot	1.30	Nonsignificant	0.24	1.54	Other	15	37
165	MAC.LAM.anti_inflammatory	1.30	Nonsignificant	1.00	0.37	Other	86	132
166	OLG.myelinating_mature	1.29	Nonsignificant	4.44e-06	1.87	Other	363	94
167	EPI.skin_keratinocyte_basal.transit_amplifying	1.28	Nonsignificant	—	0.00	Other	0	0
168	MEL.dedifferentiated_migratory	1.28	Nonsignificant	—	0.19	Other	0	0
169	EPI.salivary_intercalated_defense.inflammatory	1.27	Nonsignificant	0.97	0.33	Other	152	360
170	NK.immature_bridge	1.26	Nonsignificant	6.07e-06	1.53	Other	117	122
171	B.memory.preactivated	1.26	Nonsignificant	0.22	1.49	Other	173	174
172	T.CD4_naive.survival_neddylation	1.26	Nonsignificant	0.28	1.43	Other	26	38
173	MESO.secretory_structural	1.25	Nonsignificant	—	0.44	Other	0	0
174	B.naive.remodeling	1.25	Nonsignificant	0.95	0.61	Other	135	230
175	T.CD8_naive.effector_transition	1.24	Nonsignificant	0.04	1.69	Other	35	62
176	B.naive.activated	1.24	Nonsignificant	0.95	0.80	Other	77	127
177	T.CD4_naive.resist_bystander	1.23	Nonsignificant	0.68	1.19	Other	40	25
178	EC.capillary.angiogenic_tip	1.23	Nonsignificant	1.00	0.65	Other	186	218
179	B.naive.metabolic	1.23	Nonsignificant	0.78	1.17	Other	50	79
180	HPC.CLP_B_primed	1.23	Nonsignificant	—	0.00	Other	0	0
181	SMC.activated	1.22	Nonsignificant	0.13	1.33	Other	2	5
182	T.CD8_naive.lipid_synthesis	1.20	Nonsignificant	0.83	1.20	Other	6	4
183	B.memory.activated	1.20	Nonsignificant	1.00	0.67	Other	105	29
184	B.naive.antigen_presenting_ready	1.20	Nonsignificant	0.95	0.65	Other	48	73
185	MAC.alveolar.capillary_interacting	1.18	Nonsignificant	0.10	2.00	Other	113	181
186	T.CD4_naive.neddylation	1.18	Nonsignificant	0.68	1.13	Other	104	222
187	B.naive.baseline	1.17	Nonsignificant	0.95	0.54	Other	10	13
188	MAC.resident_iron.APC_iron_sensing	1.16	Nonsignificant	0.48	1.31	Other	211	114
189	B.memory.baseline	1.15	Nonsignificant	0.40	1.19	Other	472	99
190	MESO.activated_stress	1.15	Nonsignificant	—	0.42	Other	0	0
191	MAC.kupffer.stress	1.14	Nonsignificant	0.77	0.71	Other	9	3
192	MAC.kupffer.fibrogenic	1.14	Nonsignificant	—	0.00	Other	0	0
193	T.CD4_naive.mature	1.12	Nonsignificant	0.96	0.78	Other	211	100
194	OLG.regulatory_activated	1.11	Nonsignificant	0.96	1.07	Other	196	614
195	T.CD4_naive.purinergic	1.11	Nonsignificant	0.80	1.09	Other	49	1
196	T.CD4_naive.mature_mitoprot	1.11	Nonsignificant	0.96	0.92	Other	212	476
197	MAC.alveolar.scavenging_endocytic	1.10	Nonsignificant	—	0.64	Other	140	283
198	T.CD8_naive.nfkb_related	1.09	Nonsignificant	0.83	0.91	Other	1	0
199	T.CD4_naive.survival	1.09	Nonsignificant	0.96	0.77	Other	12	17
200	T.CD8_naive.cytokine_dampened	1.08	Nonsignificant	0.83	1.15	Other	71	4
201	OPC.homeostatic	1.07	Nonsignificant	6.27e-03	1.87	Other	394	160
202	MESO.activated_migratory	1.05	Nonsignificant	—	0.38	Other	0	0
203	T.CD4_naive.neddylation_mitoprot	1.05	Nonsignificant	0.96	0.85	Other	93	56
204	T.CD4_naive.homeostatic	1.04	Nonsignificant	0.96	0.79	Other	215	108
205	T.CD4_Trm.metal_stress	1.04	Nonsignificant	0.33	1.42	Other	34	58
206	OLG.myelinating_stress	1.03	Nonsignificant	0.96	1.06	Other	232	62
207	T.CD4_naive.survival_mitoprot	1.03	Nonsignificant	0.96	0.78	Other	13	7
208	EC.capillary.postcap_venule	1.03	Nonsignificant	1.00	0.23	Other	355	261
209	T.CD8_naive.vesicle_secretory	1.02	Nonsignificant	0.83	0.99	Other	42	0
210	MAC.kupffer.tolerogenic	1.02	Nonsignificant	—	0.00	Other	45	49
211	EC.heart_remodeling.perivascular	1.02	Nonsignificant	1.00	0.18	Other	124	408
212	MAC.alveolar.biosynthetic_sterol_heme	1.01	Nonsignificant	0.39	1.41	Other	347	40
213	B.naive.receptor_recycle	1.01	Nonsignificant	0.95	0.43	Other	51	0
214	T.CD8_naive.baseline	1.01	Nonsignificant	0.83	0.86	Other	142	2
215	MAC.alveolar.stress_metabolic	0.98	Nonsignificant	0.69	0.95	Other	116	148
216	MONO.CD14.cord_tolerance	0.98	Nonsignificant	2.31e-04	2.12	Other	864	753
217	T.CD8_naive.innate_like	0.97	Nonsignificant	0.83	0.78	Other	10	1
218	T.CD8_naive.splicing_enriched	0.96	Nonsignificant	0.83	0.96	Other	120	16
219	OLG.vesicle_trafficking	0.95	Nonsignificant	1.00	0.88	Other	124	10
220	THYMO.proliferative_S	0.95	Nonsignificant	1.00	0.26	Other	163	418
221	T.CD8_transitional.stress	0.93	Nonsignificant	—	1.22	Other	24	34
222	B.memory.migratory	0.92	Nonsignificant	1.00	0.18	Other	123	208
223	SMC.metabolic	0.92	Nonsignificant	0.80	0.99	Other	14	40
224	MAC.LAM.lipid_phagocytosis	0.92	Nonsignificant	1.00	0.10	Other	369	328
225	HEP.canalicular_transport.secretory_ERAD_UPR	0.92	Nonsignificant	1.00	0.70	Other	232	28
226	OLG.regulatory	0.92	Nonsignificant	1.00	0.51	Other	353	73
227	NK.cytokine_tissue_activation	0.89	Nonsignificant	0.28	1.40	Other	267	450
228	EPI.ileal_enterocyte_absorptive.villus_tip	0.89	Nonsignificant	1.00	0.00	Other	4	3
229	T.CD4_naive.activated_stress	0.88	Nonsignificant	0.96	0.91	Other	339	429
230	MESO.baseline	0.88	Nonsignificant	0.52	1.02	Other	0	6
231	OPC.proliferative_immune_interact	0.87	Nonsignificant	0.82	0.98	Other	180	373
232	T.CD4_Tcm.migratory_cilium	0.87	Nonsignificant	0.07	1.70	Other	5	10
233	T.CD8_Tcm.baseline	0.85	Nonsignificant	2.09e-04	1.73	Other	90	89
234	MONO.CD16.patrolling	0.85	Nonsignificant	1.00	3.63e-03	Other	797	216
235	OLG.stress	0.83	Nonsignificant	1.00	0.60	Other	232	8
236	PERI.baseline	0.81	Nonsignificant	1.00	0.01	Other	39	66
237	MAC.alveolar.inflammatory	0.81	Nonsignificant	0.96	0.25	Other	208	312
238	MG.phagocytic_APC	0.79	Nonsignificant	0.67	1.01	Other	25	8
239	T.CD4_Trm.baseline	0.74	Nonsignificant	0.33	1.29	Other	31	21
240	GRANU.neutrophil.primed_degranulation	0.74	Nonsignificant	—	0.00	Other	0	0
241	EPI.salivary_myoepithelial.baseline	0.73	Nonsignificant	0.50	1.19	Other	42	141
242	EPI.salivary_myoepithelial.activated	0.72	Nonsignificant	0.50	1.38	Other	85	281
243	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.72	Nonsignificant	—	0.37	Other	19	54
244	MAC.resident_iron.stress_tolerogenic	0.71	Nonsignificant	—	0.00	Other	0	0
245	EPI.skin_keratinocyte_progenitor.activated_stress	0.69	Nonsignificant	—	0.38	Other	0	0
246	T.CD4_Tcm.synapse_dynamics	0.69	Nonsignificant	0.26	1.51	Other	15	10
247	NEU.INH_PVALB.chandelier	0.68	Nonsignificant	0.27	1.24	Other	19	16
248	MAC.resident_iron.heme_catabolism	0.68	Nonsignificant	0.98	0.34	Other	30	51
249	FIB.hepatic_stellate_cell.contractile	0.68	Nonsignificant	—	1.15	Other	0	0
250	T.CD4_Tcm.imprinted_splicing	0.67	Nonsignificant	0.81	1.20	Other	6	17
251	HEP.periportal_metabolic.apolipoprotein_secretory	0.67	Nonsignificant	1.00	0.57	Other	43	110
252	EPI.bile_duct_cholangiocyte.secretory_mucin	0.67	Nonsignificant	—	0.22	Other	7	12
253	EPI.pancreatic_acinar.stress	0.66	Nonsignificant	0.12	1.72	Other	28	28
254	EPI.skin_follicular_keratinizing.root_infundibulum	0.65	Nonsignificant	—	0.71	Other	0	0
255	MEL.secretory_quiescent	0.65	Nonsignificant	0.15	1.45	Other	19	13
256	EPI.salivary_myoepithelial.junctional_transport	0.65	Nonsignificant	0.84	0.53	Other	66	121
257	HEP.acute_phase.complement_antiviral	0.63	Nonsignificant	0.27	1.15	Other	377	751
258	EPI.tracheal_submucosal_gland.acinar_serous	0.62	Nonsignificant	—	0.73	Other	0	0
259	EPI.salivary_intercalated_defense.basal_EMT	0.62	Nonsignificant	—	0.00	Other	0	0
260	OPC.premyelinating	0.61	Nonsignificant	0.99	0.27	Other	185	12
261	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.61	Nonsignificant	—	0.00	Other	2	0
262	HEP.canalicular_transport.inflammatory	0.60	Nonsignificant	1.00	0.15	Other	1,335	194
263	ASPC.mesothelial_like	0.59	Nonsignificant	0.58	1.26	Other	143	486
264	MG.expanding	0.59	Nonsignificant	0.67	0.80	Other	2	1
265	EPI.skin_keratinocyte_basal.basement_anchoring	0.58	Nonsignificant	—	0.00	Other	0	0
266	EPI.skin_follicular_keratinizing.upper_infundibulum	0.58	Nonsignificant	—	0.00	Other	8	2
267	T.CD4_Tcm.RNA_control	0.58	Nonsignificant	1.00	1.02	Other	96	4
268	NK.cytokine_tissue_resident	0.58	Nonsignificant	0.28	1.44	Other	74	82
269	EPI.skin_sweat_duct_keratinocyte.barrier	0.57	Nonsignificant	—	1.52	Other	0	0
270	EPI.skin_follicular_keratinizing.transit_amplifying	0.56	Nonsignificant	—	0.00	Other	21	49
271	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.56	Nonsignificant	—	0.00	Other	10	20
272	T.CD4_Tcm.DC_interact	0.56	Nonsignificant	0.45	1.34	Other	72	32
273	OLG.reactive_repair	0.56	Nonsignificant	1.00	0.08	Other	385	385
274	EC.arterial.elastic	0.56	Nonsignificant	1.00	0.24	Other	22	45
275	MEL.stress_glucocorticoid	0.56	Nonsignificant	0.78	0.99	Other	11	34
276	DC.cDC2.lipid_metabolic	0.55	Nonsignificant	—	0.00	Other	0	0
277	FIB.hepatic_stellate_cell.inflammatory	0.55	Nonsignificant	—	0.32	Other	0	0
278	EPI.skin_interfollicular_spinous.upper_lipid	0.55	Nonsignificant	—	1.07	Other	6	6
279	T.CD8_Trm.inflammatory	0.55	Nonsignificant	0.13	1.26	Other	124	176
280	EC.venous.quiescent_homeostatic	0.54	Nonsignificant	0.82	1.11	Other	456	360
281	EPI.pancreatic_acinar.baseline	0.54	Nonsignificant	0.68	1.22	Other	274	163
282	T.CD8_Trm.dendritic_recruiter	0.54	Nonsignificant	0.13	1.37	Other	47	85
283	HEP.periportal_metabolic.stress_checkpoint	0.54	Nonsignificant	1.00	0.76	Other	234	786
284	FIB.hepatic_stellate_cell.fibrogenic	0.54	Nonsignificant	—	0.00	Other	0	0
285	T.CD4_Tcm.crosstalk_myeloid	0.54	Nonsignificant	0.62	1.30	Other	5	4
286	T.CD4_Tcm.stress	0.53	Nonsignificant	1.00	1.03	Other	5	11
287	MAC.alveolar.lipid_autophagy	0.52	Nonsignificant	—	0.00	Other	35	44
288	MAC.kupffer.monocyte_like	0.52	Nonsignificant	—	0.00	Other	0	0
289	DC.cDC1.baseline	0.52	Nonsignificant	—	0.00	Other	0	0
290	MAC.resident_iron.redox_metabolic	0.51	Nonsignificant	0.98	0.19	Other	4	4
291	EPI.esophageal_suprabasal.differentiating_keratin	0.50	Nonsignificant	1.25e-05	2.21	Other	131	61
292	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.50	Nonsignificant	—	0.92	Other	0	0
293	T.CD8_Tcm.NK_like	0.50	Nonsignificant	0.44	1.26	Other	334	581
294	EPI.skin_interfollicular_spinous.stress_oxidative	0.47	Nonsignificant	—	1.14	Other	0	0
295	EPI.salivary_duct_excretory.baseline	0.47	Nonsignificant	0.08	1.89	Other	23	57
296	EPI.ileal_enterocyte_crypt.villus_transition	0.46	Nonsignificant	—	0.22	Other	7	10
297	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.45	Nonsignificant	0.01	2.48	Other	2	9
298	EPI.ileal_enterocyte_crypt.bile_transport	0.45	Nonsignificant	0.90	0.92	Other	2	0
299	EPI.ileal_enterocyte_crypt.proliferative_S	0.45	Nonsignificant	0.15	1.51	Other	4	2
300	B.germinal_center.LZ_memory_precursor	0.45	Nonsignificant	—	1.47	Other	0	0
301	EPI.ectocervical_granular.proliferative_basal	0.44	Nonsignificant	—	0.00	Other	0	0
302	T.CD4_Tcm.Tfh_like	0.43	Nonsignificant	1.00	0.98	Other	102	214
303	EPI.pancreatic_acinar.metabolic_onecarbon	0.43	Nonsignificant	0.68	1.12	Other	287	328
304	B.germinal_center.LZ_survival	0.42	Nonsignificant	—	0.37	Other	0	0
305	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	0.42	Nonsignificant	—	0.57	Other	0	0
306	EPI.salivary_duct_ion_transport.baseline	0.42	Nonsignificant	—	—	Other	0	0
307	T.CD4_Tcm.baseline	0.41	Nonsignificant	1.00	0.85	Other	61	31
308	EC.venous.activated	0.40	Nonsignificant	0.82	1.04	Other	247	752
309	HEP.acute_phase.inflammatory	0.40	Nonsignificant	0.27	1.19	Other	382	649
310	T.CD4_Tcm.APC_mimicry	0.39	Nonsignificant	1.00	0.93	Other	54	43
311	T.CD4_Trm.activated	0.39	Nonsignificant	0.76	1.17	Other	32	26
312	FIB.adventitial.mechano_chemo_sensing	0.38	Nonsignificant	1.00	0.87	Other	135	524
313	EPI.salivary_myoepithelial.contractile_repair	0.38	Nonsignificant	—	0.00	Other	3	9
314	T.CD4_Trm.central_like	0.38	Nonsignificant	0.96	0.78	Other	38	31
315	FIB.adventitial.PI16_matrix	0.37	Nonsignificant	1.00	0.84	Other	70	90
316	T.CD4_naive.Treg_like	0.37	Nonsignificant	1.00	8.09e-03	Other	121	72
317	T.CD4_Tfh.precursor_migratory	0.37	Nonsignificant	0.12	1.58	Other	72	27
318	MESO.antiviral	0.37	Nonsignificant	—	0.00	Other	3	8
319	EPI.skin_sebaceous_duct_luminal.immune_interface	0.37	Nonsignificant	—	0.09	Other	0	0
320	T.CD4_Tcm.secretory	0.37	Nonsignificant	1.00	0.65	Other	20	11
321	T.CD4_Tcm.retro_ZNF117	0.36	Nonsignificant	1.00	0.61	Other	5	9
322	MUSC.early_activation	0.36	Nonsignificant	0.11	1.84	Other	4	32
323	EPI.salivary_duct_excretory.stress	0.36	Nonsignificant	0.60	0.90	Other	33	68
324	EPI.pancreatic_acinar.inflammatory_regenerative	0.36	Nonsignificant	0.75	0.98	Other	25	113
325	T.CD8_transitional.effector_primed	0.36	Nonsignificant	0.20	1.27	Other	435	151
326	EC.venous.remodeling_stalk	0.36	Nonsignificant	1.00	0.92	Other	559	566
327	FIB.adventitial.baseline	0.35	Nonsignificant	1.00	0.82	Other	157	278
328	EPI.pancreatic_acinar.adhesion_remodeling	0.35	Nonsignificant	1.00	0.52	Other	210	784
329	T.MAIT.stress	0.35	Nonsignificant	—	1.50	Other	0	0
330	T.CD4_Tem.cytotoxic_effector	0.35	Nonsignificant	0.44	1.18	Other	225	398
331	T.CD4_Tem.transitional_CM	0.35	Nonsignificant	0.44	1.31	Other	31	20
332	B.germinal_center.LZ_selection	0.35	Nonsignificant	—	0.21	Other	0	0
333	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.35	Nonsignificant	—	1.13	Other	0	0
334	EPI.skin_sebaceous_duct_luminal.detox_repair	0.34	Nonsignificant	1.00	0.00	Other	137	94
335	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.34	Nonsignificant	—	0.00	Other	0	0
336	EPI.tracheal_submucosal_gland.ductal_luminal	0.33	Nonsignificant	—	0.00	Other	0	0
337	T.CD4_Tem.inflammatory	0.33	Nonsignificant	0.53	1.07	Other	28	6
338	EPI.skin_interfollicular_spinous.transition_basal	0.32	Nonsignificant	0.71	1.23	Other	100	127
339	EPI.gastric_foveolar.baseline	0.32	Nonsignificant	—	0.00	Other	0	0
340	EPI.renal_proximal_tubule.detox_antioxidant	0.32	Nonsignificant	0.25	1.67	Other	394	77
341	SMC.contractile	0.32	Nonsignificant	0.88	0.77	Other	80	588
342	EPI.ileal_bile_transport.absorptive_xenobiotic	0.32	Nonsignificant	0.18	1.50	Other	11	12
343	EPI.ileal_enterocyte_crypt.baseline	0.31	Nonsignificant	0.92	0.59	Other	11	6
344	T.CD4_Tcm.regulatory_poised	0.31	Nonsignificant	1.00	0.70	Other	2	3
345	FIB.adventitial.mito_secretory	0.31	Nonsignificant	1.00	0.94	Other	21	7
346	EPI.thymic_medullary.stress_APC	0.31	Nonsignificant	0.09	1.87	Other	2	4
347	T.CD4_Tcm.effector_like	0.30	Nonsignificant	1.00	0.37	Other	293	533
348	EPI.skin_interfollicular_spinous.proliferative	0.30	Nonsignificant	—	0.29	Other	0	0
349	T.CD8_Trm.homeostatic	0.29	Nonsignificant	1.00	0.85	Other	42	5
350	T.CD4_Tfh.canonical_GC_helper	0.29	Nonsignificant	0.81	0.77	Other	1	2
351	T.CD4_Trm.stress_adaptive	0.29	Nonsignificant	0.96	0.79	Other	8	22
352	FIB.adventitial.inflammatory_activated	0.29	Nonsignificant	1.00	0.59	Other	100	473
353	NEU.INH_PVALB.metabotropic	0.29	Nonsignificant	—	0.73	Other	0	0
354	EPI.thymic_medullary.hormone_xeno_barrier	0.29	Nonsignificant	—	0.23	Other	0	8
355	EC.venous.adipose_lipid	0.28	Nonsignificant	1.00	0.71	Other	254	476
356	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.28	Nonsignificant	0.92	0.28	Other	58	89
357	EPI.ileal_bile_transport.detox_transcytosis	0.28	Nonsignificant	—	0.00	Other	0	1
358	CHOND.pro_inflammatory	0.28	Nonsignificant	0.04	1.17	Other	181	351
359	T.CD8_naive.mito_proteostasis	0.28	Nonsignificant	1.00	0.00	Other	428	100
360	T.CD4_Th17.migratory	0.28	Nonsignificant	0.43	1.33	Other	13	23
361	T.CD8_Tcm.gut_homing	0.27	Nonsignificant	1.00	0.85	Other	380	112
362	HEP.periportal_metabolic.acute_phase_barrier	0.27	Nonsignificant	1.00	0.32	Other	533	138
363	ASTRO.A2_reactive	0.27	Nonsignificant	0.76	1.24	Other	10	37
364	GRANU.MAST.resting_granule	0.27	Nonsignificant	—	0.44	Other	0	0
365	EPI.thymic_medullary.canonical_alarmin	0.26	Nonsignificant	0.35	1.17	Other	8	17
366	T.gamma_delta.central_memory	0.26	Nonsignificant	0.25	1.23	Other	460	919
367	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.25	Nonsignificant	—	0.00	Other	135	290
368	FIB.reticular.stromal_niche	0.25	Nonsignificant	0.02	1.49	Other	0	0
369	EPI.cervical_suprabasal.secretory_vesicle	0.25	Nonsignificant	—	0.00	Other	0	0
370	EC.venous.baseline	0.25	Nonsignificant	1.00	0.71	Other	346	807
371	GRANU.MAST.activated_acute	0.25	Nonsignificant	—	0.19	Other	0	0
372	T.CD4_Tfh.effector_migratory	0.24	Nonsignificant	0.81	0.72	Other	122	57
373	EPI.esophageal_basal.activated_progenitor	0.24	Nonsignificant	0.07	1.80	Other	1	0
374	EPI.skin_interfollicular_spinous.baseline	0.24	Nonsignificant	0.71	0.83	Other	35	3
375	B.germinal_center.DZ_S_phase	0.24	Nonsignificant	—	0.00	Other	0	0
376	T.CD4_Tfh.suppression_exhaustion	0.24	Nonsignificant	0.14	1.53	Other	0	2
377	MEL.mature_oxidative_traffic	0.23	Nonsignificant	1.00	0.18	Other	247	285
378	T.CD8_Trm.muscosal_Tc17	0.23	Nonsignificant	1.00	0.79	Other	19	38
379	T.CD4_Trm.cytotoxic_effector	0.23	Nonsignificant	0.96	0.62	Other	118	77
380	EPI.alveolar_type_2.baseline_surfactant	0.23	Nonsignificant	0.16	1.27	Other	64	9
381	T.CD8_Trm.cytotoxic	0.23	Nonsignificant	1.00	0.60	Other	165	85
382	EPI.lung_club_secretory.canonical_surfactant	0.22	Nonsignificant	—	0.75	Other	74	104
383	T.CD4_Tcm.Th2_like	0.22	Nonsignificant	1.00	0.23	Other	23	55
384	T.CD8_transitional.early	0.22	Nonsignificant	0.82	1.04	Other	327	55
385	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.21	Nonsignificant	—	0.00	Other	43	26
386	T.CD4_Th17.baseline	0.21	Nonsignificant	0.82	0.73	Other	51	5
387	T.CD4_Tcm.tissue_homing	0.21	Nonsignificant	1.00	0.09	Other	78	46
388	FIB.barrier_purinergic.lipid_secretory	0.21	Nonsignificant	—	0.48	Other	0	0
389	T.CD4_Trm.helper_like	0.21	Nonsignificant	0.96	0.65	Other	84	147
390	T.CD4_Tem.long_term_memory	0.20	Nonsignificant	0.96	0.62	Other	314	587
391	FIB.adventitial.complement_angiocrine	0.20	Nonsignificant	1.00	0.23	Other	153	684
392	EPI.skin_interfollicular_spinous.early_differentiation	0.20	Nonsignificant	0.71	0.81	Other	89	19
393	NEU.INH_VIP.LAMP5_hybrid	0.20	Nonsignificant	—	1.75	Other	1	9
394	EPI.tracheal_basal.homeostatic_progenitor	0.20	Nonsignificant	0.80	0.61	Other	285	74
395	EPI.tracheal_basal.activated_stress	0.20	Nonsignificant	0.80	0.99	Other	32	0
396	T.CD8_Tcm.helper_like	0.20	Nonsignificant	1.00	0.23	Other	81	159
397	HEP.acute_phase.baseline	0.19	Nonsignificant	1.00	0.95	Other	946	19
398	T.gamma_delta.early_effector	0.19	Nonsignificant	0.67	0.93	Other	89	0
399	EPI.skin_sweat_duct_keratinocyte.repair	0.19	Nonsignificant	—	0.00	Other	0	0
400	EPI.cervical_suprabasal.inflammatory_repair	0.18	Nonsignificant	—	0.00	Other	0	0
401	FIB.lung_alveolar.mito_secretory	0.18	Nonsignificant	—	0.00	Other	0	0
402	T.CD4_Th17.cytotoxic	0.18	Nonsignificant	0.82	0.75	Other	332	123
403	EPI.endocervical_secretory.squamous_barrier	0.18	Nonsignificant	—	0.67	Other	0	0
404	EPI.esophageal_suprabasal.proliferative_exit	0.18	Nonsignificant	—	0.00	Other	0	0
405	EPI.tracheal_suprabasal.transitional_wound	0.18	Nonsignificant	—	0.60	Other	16	1
406	MEL.neurotrophic_migratory	0.17	Nonsignificant	—	0.00	Other	0	0
407	EPI.skin_interfollicular_spinous.stress_UPR	0.17	Nonsignificant	—	0.00	Other	0	0
408	EPI.thymic_medullary.proliferative_APC	0.17	Nonsignificant	—	0.00	Other	0	0
409	HEP.acute_phase.stress_secretory	0.17	Nonsignificant	1.00	0.84	Other	26	3
410	T.CD4_transitional.baseline	0.17	Nonsignificant	0.27	1.40	Other	59	97
411	T.CD8_Tcm.effector_bias	0.17	Nonsignificant	1.00	0.32	Other	199	329
412	EPI.alveolar_type_2.stress_response	0.17	Nonsignificant	0.16	1.22	Other	675	1,562
413	NEU.EXC_CT.remodeling	0.17	Nonsignificant	—	0.82	Other	23	1
414	HEP.acute_phase.proliferative	0.17	Nonsignificant	—	0.14	Other	4	6
415	NEU.EXC_CT.Ca2_sensor	0.16	Nonsignificant	—	1.16	Other	0	0
416	GRANU.MAST.activated_repair	0.16	Nonsignificant	—	0.00	Other	0	1
417	EPI.esophageal_suprabasal.proliferative_S	0.16	Nonsignificant	—	0.00	Other	26	41
418	EPI.skin_keratinocyte_proliferating.detox_repair	0.16	Nonsignificant	—	0.00	Other	0	0
419	T.MAIT.migratory	0.15	Nonsignificant	0.72	1.29	Other	10	1
420	T.MAIT.MAPK_brake	0.15	Nonsignificant	0.72	1.29	Other	44	66
421	T.gamma_delta.cytotoxic_effector	0.15	Nonsignificant	0.25	1.20	Other	349	109
422	EPI.esophageal_suprabasal.proliferative_G2M	0.14	Nonsignificant	—	0.00	Other	0	0
423	ASTRO.hypoxia_angiogenic	0.14	Nonsignificant	0.76	1.14	Other	5	18
424	EPI.skin_interfollicular_spinous.inflammatory	0.14	Nonsignificant	—	0.00	Other	0	0
425	FIB.lung_alveolar.stress_interacting	0.14	Nonsignificant	—	0.00	Other	0	0
426	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.14	Nonsignificant	—	0.00	Other	0	0
427	T.CD4_transitional.primed_helper_effector	0.14	Nonsignificant	0.81	1.15	Other	19	43
428	NK.cytokine_axis_baseline	0.14	Nonsignificant	1.00	0.81	Other	1,172	116
429	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.13	Nonsignificant	—	0.00	Other	0	0
430	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.13	Nonsignificant	0.51	1.25	Other	33	34
431	MUSC.baseline	0.13	Nonsignificant	0.94	0.59	Other	0	0
432	NK.adaptive_adipose_stress	0.13	Nonsignificant	1.00	0.89	Other	374	39
433	T.CD8_transitional.APC_like	0.13	Nonsignificant	1.00	0.51	Other	205	62
434	EPI.renal_intercalated_cell_type_B.baseline	0.13	Nonsignificant	—	0.00	Other	3	1
435	NK.cytokine_repair_primed	0.12	Nonsignificant	1.00	0.69	Other	266	11
436	EPI.esophageal_suprabasal.basal_transitional	0.12	Nonsignificant	1.00	0.00	Other	44	67
437	T.CD4_cytotoxic.activated	0.12	Nonsignificant	0.47	1.34	Other	3	1
438	T.CD8_transitional.Trm_primed	0.12	Nonsignificant	1.00	0.74	Other	108	15
439	T.CD4_transitional.primed_cytotoxic	0.12	Nonsignificant	0.83	0.77	Other	28	30
440	T.CD4_cytotoxic.NK_adapted	0.12	Nonsignificant	0.62	1.12	Other	82	33
441	T.CD4_cytotoxic.precursor	0.12	Nonsignificant	0.55	1.27	Other	156	67
442	MUSC.activated_migratory	0.12	Nonsignificant	0.94	0.65	Other	6	7
443	NK.cytokine_vascular_patrolling	0.12	Nonsignificant	1.00	0.58	Other	863	94
444	T.CD4_transitional.APC_interacting	0.11	Nonsignificant	0.83	0.64	Other	10	14
445	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.11	Nonsignificant	0.67	0.84	Other	7	16
446	EPI.lung_club_secretory.ciliogenesis_primed	0.11	Nonsignificant	—	0.37	Other	0	0
447	T.MAIT.quiescent	0.11	Nonsignificant	0.90	0.83	Other	100	5
448	EPI.pancreatic_acinar.quiet_dedifferentiation	0.11	Nonsignificant	1.00	0.06	Other	142	171
449	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.10	Nonsignificant	—	0.73	Other	0	0
450	CM.inflammatory	0.10	Nonsignificant	—	0.00	Other	0	0
451	EPI.esophageal_basal.junctional_barrier	0.10	Nonsignificant	—	0.00	Other	0	0
452	NK.cytokine_biosynthetic_primed	0.10	Nonsignificant	1.00	0.64	Other	360	21
453	T.CD4_transitional.tissue_enagement	0.10	Nonsignificant	0.83	0.65	Other	5	11
454	T.CD4_Treg.tissue_effector	0.10	Nonsignificant	0.12	1.34	Other	16	13
455	EPI.salivary_serous_acinar.secretory_active	0.10	Nonsignificant	1.00	0.00	Other	242	69
456	NEU.INH_PVALB.serotonergic	0.10	Nonsignificant	—	0.14	Other	0	0
457	T.MAIT.vesicle	0.09	Nonsignificant	0.90	0.59	Other	37	65
458	T.MAIT.cytotoxic	0.09	Nonsignificant	0.90	0.52	Other	52	15
459	T.CD4_Th2.precursor	0.09	Nonsignificant	—	0.48	Other	0	0
460	GRNLSA.stress_metabolic	0.09	Nonsignificant	—	0.89	Other	1	2
461	NK.adaptive_immature_precursor	0.09	Nonsignificant	1.00	0.57	Other	358	111
462	NK.cytokine_quiescent	0.09	Nonsignificant	1.00	0.45	Other	623	1,062
463	FIB.perivascular_interface.vascular_BM_remodelling	0.08	Nonsignificant	—	0.73	Other	0	0
464	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.08	Nonsignificant	—	0.97	Other	0	0
465	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.08	Nonsignificant	—	0.00	Other	39	82
466	T.MAIT.early_activation	0.08	Nonsignificant	0.90	0.55	Other	57	4
467	EPI.skin_appendage_keratinocyte.transit_amplifying	0.08	Nonsignificant	—	0.00	Other	109	358
468	T.CD4_Treg.Tr1_like	0.08	Nonsignificant	—	0.61	Other	8	8
469	MUSC.quiescent_reservoir	0.07	Nonsignificant	0.94	0.32	Other	2	8
470	EPI.thymic_cortical.secretory_remodeling	0.07	Nonsignificant	—	0.00	Other	4	1
471	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.07	Nonsignificant	—	0.00	Other	0	0
472	EPI.renal_intercalated_cell_type_A.acid_secretion	0.07	Nonsignificant	0.61	1.00	Other	12	6
473	HEP.acute_phase.hypoxia_lipid	0.06	Nonsignificant	—	0.13	Other	0	0
474	T.CD8_Tem.baseline	0.06	Nonsignificant	0.28	1.19	Other	458	356
475	NK.adaptive_HLAE_tuned	0.06	Nonsignificant	1.00	0.58	Other	1,124	189
476	T.CD8_Tem.early_helper_like	0.05	Nonsignificant	0.69	1.08	Other	445	755
477	FIB.interstitial.mesenchymal_regulator	0.05	Nonsignificant	0.70	1.09	Other	4	4
478	EPI.ileal_goblet.immature	0.05	Nonsignificant	—	1.44	Other	0	0
479	T.CD4_Treg.central_naive_like	0.05	Nonsignificant	0.32	1.14	Other	333	45
480	NK.adaptive_classII_inhibitory	0.05	Nonsignificant	1.00	0.47	Other	880	154
481	FIB.perivascular_interface.vasomotor_tone	0.05	Nonsignificant	—	0.36	Other	0	0
482	T.CD8_Tem.TEMRA	0.05	Nonsignificant	0.69	0.98	Other	920	1,088
483	NK.adaptive_biosynthetic_primed	0.04	Nonsignificant	1.00	0.35	Other	244	405
484	FIB.interstitial.mesenchymal_APC	0.04	Nonsignificant	0.93	0.99	Other	81	33
485	FIB.reticular.immune_interface	0.04	Nonsignificant	—	0.00	Other	1	6
486	GRNLSA.lipid_hypoxia	0.04	Nonsignificant	0.77	1.06	Other	28	0
487	FIB.interstitial.immune_interact	0.04	Nonsignificant	0.93	0.97	Other	12	1
488	NK.adaptive_axis_baseline	0.04	Nonsignificant	1.00	0.15	Other	1,008	153
489	EPI.renal_immature_ureteric_bud.defense_secretory	0.04	Nonsignificant	0.28	1.15	Other	45	76
490	FIB.interstitial.remodeling	0.04	Nonsignificant	0.70	1.06	Other	31	9
491	NK.adaptive_terminal_cytotoxic	0.04	Nonsignificant	1.00	0.15	Other	485	802
492	GRNLSA.EMT_insulin_signaling	0.03	Nonsignificant	0.77	1.21	Other	47	84
493	T.CD8_Tem.stress_adapted	0.03	Nonsignificant	0.69	0.98	Other	607	520
494	GRNLSA.chemokine_mechanosensory	0.03	Nonsignificant	0.77	1.03	Other	1	0
495	T.CD8_Tem.motility_primed	0.03	Nonsignificant	0.20	1.41	Other	269	4
496	EPI.pancreatic_islet.alpha	0.03	Nonsignificant	—	0.87	Other	152	330
497	ASTRO.stress_mito	0.03	Nonsignificant	0.76	1.15	Other	47	110
498	ASPC.niche_keeping_progenitor	0.03	Nonsignificant	0.58	1.12	Other	52	219
499	EPI.alveolar_type_1.activated	0.03	Nonsignificant	—	1.64	Other	0	0
500	T.CD4_cytotoxic.terminal_effector	0.03	Nonsignificant	1.00	0.35	Other	286	21
501	GRNLSA.cholesterol_mevalonate	0.02	Nonsignificant	0.77	1.14	Other	9	4
502	EPI.renal_intercalated_cell_type_A.PC_transitional	0.02	Nonsignificant	—	0.00	Other	203	407
503	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.02	Nonsignificant	—	1.32	Other	29	88
504	EPI.thymic_cortical.Notch_interface	0.02	Nonsignificant	—	0.62	Other	82	137
505	ASTRO.synaptic_interaction	0.02	Nonsignificant	0.99	0.91	Other	76	334
506	T.CD4_cytotoxic.baseline	0.02	Nonsignificant	0.95	0.74	Other	0	0
507	NEU.INH_VIP.regulatory_remodeling	0.02	Nonsignificant	—	0.74	Other	6	1
508	T.CD8_Tem.signaling_turnover	0.02	Nonsignificant	0.96	0.58	Other	425	683
509	EPI.renal_distal_tubule.stress	0.02	Nonsignificant	—	0.63	Other	0	0
510	ASPC.activated	0.02	Nonsignificant	1.00	1.02	Other	164	162
511	ASTRO.homeostatic	0.02	Nonsignificant	0.99	0.97	Other	200	431
512	NEU.EXC_CT.Ca2_signaling	0.02	Nonsignificant	—	0.09	Other	68	17
513	HEP.acute_phase.complement_metabolic	0.02	Nonsignificant	1.00	0.50	Other	1,423	3,464
514	ASTRO.stress_acute	0.02	Nonsignificant	0.76	1.10	Other	60	56
515	ASPC.adipocyte_capillary_interface	0.02	Nonsignificant	1.00	1.01	Other	21	54
516	EPI.thymic_cortical.baseline	0.02	Nonsignificant	0.86	0.32	Other	185	386
517	FIB.skin_neurosecretory.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
518	FIB.reticular.ECM_builder	0.02	Nonsignificant	—	0.00	Other	0	0
519	EPI.colonocyte.distal_absorptive	0.02	Nonsignificant	—	2.20	Other	0	0
520	EPI.colonic_enteroendocrine.Lcell_peptide	0.01	Nonsignificant	—	0.00	Other	0	0
521	FIB.reticular.stress_metallothionein	0.01	Nonsignificant	—	0.00	Other	3	32
522	T.CD4_Treg.APC_interactive	0.01	Nonsignificant	1.00	0.56	Other	118	28
523	ASPC.preadipocyte_lipid_primed	0.01	Nonsignificant	0.95	1.04	Other	331	129
524	EPI.renal_distal_tubule.ciliated_remodelling	0.01	Nonsignificant	—	1.04	Other	0	0
525	EPI.renal_principal_cell.activated_acute	0.01	Nonsignificant	1.00	1.16	Other	29	59
526	HEP.pericentral_lipoprotein.ApoB_coagulation	0.01	Nonsignificant	—	0.67	Other	0	0
527	ASTRO.A1_reactive	0.01	Nonsignificant	0.99	0.84	Other	433	394
528	NEU.EXC_SYT2.synaptic	0.01	Nonsignificant	—	0.48	Other	0	0
529	NEU.INH_PVALB.fastspike	0.01	Nonsignificant	—	0.00	Other	24	22
530	EPI.ileal_enterocyte_crypt.secretory_precursor	0.01	Nonsignificant	—	0.00	Other	0	0
531	NEU.EXC_IT.structural	0.01	Nonsignificant	0.37	1.09	Other	171	41
532	NEU.INH_VIP.canonical_disinhibitory	9.99e-03	Nonsignificant	0.50	1.03	Other	59	38
533	CHOND.articular_collagen	9.88e-03	Nonsignificant	1.00	0.81	Other	551	266
534	NEU.INH_VIP.enkephalinergic	9.15e-03	Nonsignificant	—	0.45	Other	0	0
535	ASTRO.immature_lipid	8.45e-03	Nonsignificant	0.99	0.77	Other	23	113
536	CHOND.angiogenic	8.35e-03	Nonsignificant	—	0.70	Other	0	0
537	FIB.interstitial.stress_secretory	7.80e-03	Nonsignificant	0.98	0.86	Other	92	56
538	FIB.perivascular_interface.lipid_shuttle	7.44e-03	Nonsignificant	—	0.00	Other	51	170
539	EPI.renal_thick_ascending_limb.canonical_salt_transporter	7.39e-03	Nonsignificant	0.54	1.13	Other	322	317
540	EPI.colonic_tuft.homeostatic	7.00e-03	Nonsignificant	—	0.42	Other	0	0
541	NEU.INH_PVALB.neuromodulatory	6.74e-03	Nonsignificant	—	0.00	Other	0	0
542	HEP.pericentral_lipoprotein.UPR_redox	6.11e-03	Nonsignificant	—	0.00	Other	0	0
543	NEU.INH_VIP.serotonergic	5.96e-03	Nonsignificant	—	0.29	Other	9	2
544	GRNLSA.proliferative_migratory	4.28e-03	Nonsignificant	0.98	0.85	Other	248	292
545	EPI.colonic_tuft.activated	4.14e-03	Nonsignificant	—	0.00	Other	0	0
546	NEU.EXC_CT.projector	4.10e-03	Nonsignificant	1.00	0.00	Other	87	26
547	IPSC.mesendo_primed	4.04e-03	Nonsignificant	0.61	1.02	Other	0	0
548	T.CD4_Th2.tissue_adapted	4.02e-03	Nonsignificant	—	0.00	Other	0	0
549	ASPC.secretory	3.84e-03	Nonsignificant	1.00	0.89	Other	76	5
550	NEU.INH_VIP.opioid	3.77e-03	Nonsignificant	—	0.00	Other	50	9
551	SCHWN.reactive_inflammatory	3.72e-03	Nonsignificant	—	0.98	Other	0	0
552	ASPC.inflammatory	3.66e-03	Nonsignificant	1.00	0.94	Other	21	61
553	FIB.skin_sheath.stress_chaperone	3.38e-03	Nonsignificant	—	0.00	Other	0	0
554	EPI.alveolar_type_2.injury_primed	3.12e-03	Nonsignificant	1.00	0.00	Other	434	245
555	SCHWN.translation_boost	3.07e-03	Nonsignificant	—	0.18	Other	8	1
556	EPI.tracheal_suprabasal.secretory_immune	2.95e-03	Nonsignificant	—	0.00	Other	0	0
557	EPI.pancreatic_islet.beta	2.88e-03	Nonsignificant	0.95	0.54	Other	42	57
558	ASPC.baseline	2.79e-03	Nonsignificant	1.00	0.85	Other	363	170
559	EPI.renal_immature_ureteric_bud.osmoprotective	2.65e-03	Nonsignificant	1.00	0.41	Other	126	44
560	EPI.colonocyte.ionocyte_BEST4	2.64e-03	Nonsignificant	0.92	1.17	Other	103	188
561	B.germinal_center.DZ_M_phase	2.21e-03	Nonsignificant	—	0.00	Other	0	0
562	EPI.renal_principal_cell.inflammatory	2.03e-03	Nonsignificant	1.00	1.09	Other	74	157
563	EPI.renal_thick_ascending_limb.salt_sensing	1.96e-03	Nonsignificant	0.77	1.10	Other	73	103
564	GRNLSA.p53_damage	1.77e-03	Nonsignificant	—	0.00	Other	13	10
565	FIB.suburothelial.urothelial_interface	1.75e-03	Nonsignificant	0.39	1.32	Other	9	8
566	NEU.INH_PVALB.nuclear_reg	1.68e-03	Nonsignificant	1.00	8.75e-03	Other	25	12
567	EPI.ectocervical_granular.immune_interact	1.60e-03	Nonsignificant	—	0.00	Other	0	0
568	FIB.transitioning.matrix_stress	1.40e-03	Nonsignificant	—	0.00	Other	47	138
569	CHOND.remodeling	1.25e-03	Nonsignificant	—	0.00	Other	5	0
570	EPI.colonocyte.proximal_transport	1.19e-03	Nonsignificant	0.92	1.06	Other	24	12
571	FIB.tracheal_subepithelial.baseline	1.14e-03	Nonsignificant	—	0.00	Other	0	0
572	EPI.lung_club_secretory.ciliogenesis_axoneme	1.12e-03	Nonsignificant	—	0.00	Other	0	0
573	EPI.lung_multiciliated.stress	1.09e-03	Nonsignificant	—	0.69	Other	67	165
574	GRNLSA.angiocrine_mechanosensory	1.08e-03	Nonsignificant	—	0.00	Other	0	0
575	FIB.barrier_purinergic.stress_GF_binding	1.08e-03	Nonsignificant	—	0.00	Other	0	0
576	FIB.barrier_secretory.homeostasis	1.00e-03	Nonsignificant	—	0.60	Other	0	0
577	ASTRO.neuromodulatory	8.91e-04	Nonsignificant	0.99	0.59	Other	34	172
578	EPI.alveolar_type_1.baseline	7.96e-04	Nonsignificant	1.00	0.00	Other	8	0
579	GRNLSA.secretory_remodeling	7.81e-04	Nonsignificant	1.00	0.38	Other	90	25
580	CHOND.activated_fibro_like	7.18e-04	Nonsignificant	1.00	0.69	Other	531	188
581	EPI.pancreatic_ductal_progenitor.ADM_like	6.89e-04	Nonsignificant	—	1.79	Other	0	0
582	NEU.INH_VIP.excitatory_coupled	6.88e-04	Nonsignificant	—	0.00	Other	13	0
583	EPI.skin_hair_follicle_companion.activated_migratory	6.03e-04	Nonsignificant	—	0.97	Other	0	0
584	FIB.interstitial.lipid_matrix	5.58e-04	Nonsignificant	1.00	0.37	Other	258	191
585	FIB.transitioning.secretory_procollagen	5.40e-04	Nonsignificant	—	0.92	Other	0	0
586	IPSC.proliferative	5.18e-04	Nonsignificant	0.61	1.01	Other	0	0
587	FIB.suburothelial.inflammatory_prostanoid	4.28e-04	Nonsignificant	—	0.25	Other	0	0
588	NEU.INH_VIP.nuclear_reg	3.61e-04	Nonsignificant	—	0.00	Other	20	4
589	FIB.suburothelial.homeostasis_matrix	3.54e-04	Nonsignificant	0.49	1.05	Other	258	921
590	FIB.neurolectin_mucosa.nerve_interface	2.70e-04	Nonsignificant	—	0.57	Other	4	0
591	EPI.skin_hair_follicle_bulge.quiescent	2.58e-04	Nonsignificant	0.98	0.26	Other	56	69
592	IPSC.stress	2.54e-04	Nonsignificant	0.61	1.06	Other	0	0
593	NEU.INH_VIP.cannabinoid	2.49e-04	Nonsignificant	—	0.00	Other	0	0
594	EPI.pancreatic_ductal_perivascular.baseline	2.35e-04	Nonsignificant	0.27	1.19	Other	1	5
595	IPSC.neuroendocrine_primed	2.33e-04	Nonsignificant	—	1.88	Other	0	0
596	ADIPO.immature	2.27e-04	Nonsignificant	—	0.53	Other	24	40
597	EPI.colonocyte.goblet_interface	2.27e-04	Nonsignificant	—	0.36	Other	11	21
598	EPI.lung_multiciliated.baseline	2.20e-04	Nonsignificant	—	0.00	Other	0	7
599	EPI.colonocyte.junction_remodeling	2.00e-04	Nonsignificant	0.92	0.98	Other	218	305
600	NEU.INH_VIP.develop_niche	1.88e-04	Nonsignificant	—	0.00	Other	0	0
601	IPSC.canonical_pluripotent	1.86e-04	Nonsignificant	0.99	0.99	Other	0	0
602	EPI.renal_thick_ascending_limb.barrier_repair	1.72e-04	Nonsignificant	1.00	0.92	Other	141	284
603	EPI.extrahepatic_cholangiocyte.barrier_interface	1.72e-04	Nonsignificant	—	0.00	Other	0	0
604	ADIPO.hypoxia_remodelling	1.69e-04	Nonsignificant	—	0.20	Other	29	105
605	IPSC.endoderm_primed	1.56e-04	Nonsignificant	0.61	1.14	Other	0	0
606	FIB.suburothelial.contractile_myofibroblast	1.55e-04	Nonsignificant	—	0.00	Other	9	0
607	ASPC.proliferative	1.53e-04	Nonsignificant	1.00	0.73	Other	33	85
608	FIB.neurolectin_mucosa.remodeling_repair	1.46e-04	Nonsignificant	—	0.82	Other	4	2
609	EPI.renal_principal_cell.canonical_vasopressin	1.32e-04	Nonsignificant	1.00	0.94	Other	2	0
610	ASPC.remodeling	1.29e-04	Nonsignificant	1.00	0.65	Other	106	354
611	EPI.skin_hair_follicle_bulge.anagen_growth	1.18e-04	Nonsignificant	—	0.00	Other	0	0
612	EPI.colonic_enteroendocrine.progenitor	1.06e-04	Nonsignificant	—	0.00	Other	0	0
613	EPI.renal_thick_ascending_limb.cation_flux	1.01e-04	Nonsignificant	1.00	0.77	Other	57	95
614	IPSC.neural_primed	8.47e-05	Nonsignificant	0.70	1.02	Other	0	0
615	FIB.skin_tenogenic.baseline	8.38e-05	Nonsignificant	—	0.00	Other	0	2
616	IPSC.mesodermal_primed	6.05e-05	Nonsignificant	0.65	1.06	Other	0	0
617	EPI.endocervical_secretory.secretory_translocon	5.66e-05	Nonsignificant	—	0.00	Other	0	0
618	FIB.transitioning.ISG_primed_interface	5.25e-05	Nonsignificant	—	0.00	Other	17	80
619	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	4.51e-05	Nonsignificant	—	0.00	Other	0	0
620	EPI.lung_multiciliated.mature_motile_cilia	4.36e-05	Nonsignificant	—	0.00	Other	0	0
621	FIB.transitioning.motility_remodelling	3.79e-05	Nonsignificant	—	0.00	Other	0	0
622	EPI.colonocyte.crypt_progenitor	3.51e-05	Nonsignificant	0.92	0.88	Other	115	265
623	ASPC.stem_like_progenitor	3.25e-05	Nonsignificant	1.00	0.62	Other	300	842
624	SCHWN.axon_contact_cardiac	2.29e-05	Nonsignificant	0.99	0.25	Other	18	63
625	EPI.pancreatic_ductal_bicarbonate.stress	1.39e-05	Nonsignificant	—	0.49	Other	12	33
626	EPI.colonocyte.secretory_boost	1.09e-05	Nonsignificant	0.92	0.94	Other	98	91
627	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.09e-05	Nonsignificant	—	0.00	Other	0	0
628	EPI.pancreatic_ductal_perivascular.protective_antioxidant	9.60e-06	Nonsignificant	—	0.00	Other	11	69
629	EPI.renal_thick_ascending_limb.remodeling	8.35e-06	Nonsignificant	1.00	0.48	Other	152	92
630	EPI.pancreatic_ductal_bicarbonate.baseline	6.01e-06	Nonsignificant	0.20	1.13	Other	11	42
631	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	4.44e-06	Nonsignificant	—	0.30	Other	0	0
632	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	4.23e-06	Nonsignificant	—	0.00	Other	0	0
633	FIB.neurolectin_mucosa.axon_responsive	4.19e-06	Nonsignificant	0.95	0.57	Other	10	10
634	EPI.ileal_goblet.baseline	4.01e-06	Nonsignificant	0.78	1.15	Other	16	2
635	EPI.pancreatic_ductal_bicarbonate.inflammatory	3.56e-06	Nonsignificant	0.22	1.22	Other	14	32
636	FIB.skin_sheath.ECM_immune	2.54e-06	Nonsignificant	—	0.00	Other	0	0
637	FIB.skin_sheath.neuro_vascular_interface	1.97e-06	Nonsignificant	—	6.94e-17	Other	0	0
638	EPI.pancreatic_islet.delta	1.65e-06	Nonsignificant	—	0.00	Other	0	0
639	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.63e-06	Nonsignificant	—	0.00	Other	0	0
640	FIB.neurolectin_mucosa.inflammatory	1.40e-06	Nonsignificant	0.95	0.47	Other	52	110
641	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.14e-06	Nonsignificant	—	0.51	Other	6	9
642	IPSC.axial_identity_primed	1.14e-06	Nonsignificant	0.99	0.92	Other	0	0
643	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	8.24e-07	Nonsignificant	0.93	0.90	Other	219	533
644	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	6.18e-07	Nonsignificant	0.85	1.05	Other	40	191
645	NEU.INH_VIP.matrix	4.43e-07	Nonsignificant	—	0.00	Other	24	77
646	EPI.renal_principal_cell.injury_repair	4.08e-07	Nonsignificant	1.00	0.59	Other	26	9
647	EPI.renal_distal_tubule.repair	3.76e-07	Nonsignificant	—	0.40	Other	34	102
648	FIB.skin_papillary.baseline	2.15e-07	Nonsignificant	—	0.00	Other	0	0
649	EPI.lung_club_secretory.inflammatory	2.00e-07	Nonsignificant	—	0.00	Other	0	0
650	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	6.81e-08	Nonsignificant	—	0.61	Other	0	0
651	EPI.ileal_goblet.inflammatory_mucin	6.73e-08	Nonsignificant	0.78	0.66	Other	6	9
652	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	5.80e-08	Nonsignificant	—	0.73	Other	0	0
653	ADIPO.thermogenic	5.04e-08	Nonsignificant	—	0.00	Other	0	0
654	EPI.ileal_goblet.stress_metallothionein	4.37e-08	Nonsignificant	—	0.00	Other	4	11
655	IPSC.stromal_primed	2.96e-08	Nonsignificant	0.99	0.94	Other	0	0
656	EPI.pancreatic_ductal_progenitor.baseline	2.43e-08	Nonsignificant	0.98	0.57	Other	179	702
657	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.92e-08	Nonsignificant	—	0.54	Other	0	0
658	IPSC.mesenchymal_primed	1.82e-08	Nonsignificant	0.99	0.91	Other	0	0
659	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.17e-08	Nonsignificant	—	0.00	Other	0	0
660	EPI.hepatic_ductular_cholangiocyte.stress	1.16e-08	Nonsignificant	—	0.58	Other	0	0
661	EPI.hepatic_ductular_cholangiocyte.polarity	1.11e-08	Nonsignificant	—	0.00	Other	0	0
662	FIB.barrier_secretory.remodeling	8.74e-09	Nonsignificant	—	0.00	Other	0	0
663	EPI.pancreatic_ductal_bicarbonate.activated	7.69e-09	Nonsignificant	0.93	0.68	Other	10	7
664	IPSC.midbrain_primed	3.75e-09	Nonsignificant	0.99	0.87	Other	0	0
665	NEU.EXC_IT.transitional	3.15e-09	Nonsignificant	0.98	1.00	Other	237	142
666	EPI.pancreatic_ductal_progenitor.ciliated_transport	3.11e-09	Nonsignificant	—	0.00	Other	105	368
667	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.11e-09	Nonsignificant	—	0.00	Other	0	0
668	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.62e-09	Nonsignificant	—	0.00	Other	0	0
669	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	1.45e-09	Nonsignificant	—	0.03	Other	5	3
670	NEU.EXC_IT.guidance	3.89e-10	Nonsignificant	0.98	0.88	Other	274	63
671	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	3.10e-10	Nonsignificant	—	0.00	Other	49	237
672	NEU.EXC_IT.callosal	1.86e-10	Nonsignificant	0.98	0.84	Other	286	119
673	EPI.hepatic_ductular_cholangiocyte.secretory_transport	1.79e-10	Nonsignificant	—	0.00	Other	0	0
674	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	6.89e-11	Nonsignificant	0.44	1.13	Other	449	1,034
675	EPI.renal_principal_cell.intercalated_like	4.55e-11	Nonsignificant	1.00	0.00	Other	63	66
676	ASPC.signal_integrator	3.71e-11	Nonsignificant	—	0.00	Other	0	0
677	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	3.48e-11	Nonsignificant	—	0.85	Other	0	0
678	NEU.EXC_IT.neuromodulated	1.53e-11	Nonsignificant	0.98	0.85	Other	176	116
679	NEU.EXC_IT.adhesion	1.41e-11	Nonsignificant	0.98	0.75	Other	252	108
680	EPI.hepatic_ductular_cholangiocyte.ion_transport	5.63e-12	Nonsignificant	—	0.00	Other	0	0
681	EPI.renal_distal_tubule.ion_transport	3.41e-12	Nonsignificant	—	0.00	Other	0	0
682	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	8.28e-13	Nonsignificant	—	0.00	Other	0	0
683	NEU.EXC_SYT2.nuclear_reg	5.72e-13	Nonsignificant	—	0.00	Other	0	0
684	NEU.EXC_NTNG1.synaptic	3.09e-13	Nonsignificant	—	0.67	Other	0	0
685	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.14e-13	Nonsignificant	—	0.00	Other	0	0
686	EPI.renal_distal_tubule.immune_modulatory	6.38e-14	Nonsignificant	—	0.00	Other	0	0
687	ADIPO.inflammatory	2.60e-15	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_NTNG1.nuclear_reg	4.82e-17	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

77 unique genes. Showing 1–77. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
AGPAT3	02-Medium	0.69	26.63	G1	C2	—	—	20 cells — complete matches	2	5
PFKL	02-Medium	0.67	25.53	G1	C2	—	—	—	34	105
ENSG00000295834	02-Medium	0.66	28.70	G1	C2	—	—	—	5	14
ENSG00000232124	02-Medium	0.64	25.17	G1	C2	—	—	—	27	77
AATBC	02-Medium	0.62	30.22	G1	C2	—	DC.cDC1.homeostatic_inhibitory (Tier: relevant)	20 cells — complete matches	1	1
LINC00313	02-Medium	0.60	30.42	G1	C2	—	EC.lymphatic.valve (Tier: relevant)	25 cells — complete matches	3	5
ICOSLG	02-Medium	0.60	25.50	G1	C2	—	—	50 cells — complete matches	5	14
SIK1	02-Medium	0.60	24.12	G1	C2	EPI.skin_interfollicular_spinous.stress_UPR (L2)	—	57 cells — complete matches	5	13
PDXK	02-Medium	0.60	25.56	G1	C2	—	—	5 cells — complete matches	2	4
ENSG00000278158	02-Medium	0.58	25.25	G1	C2	—	—	—	5	14
ENSG00000285413	02-Medium	0.57	16.00	G1	C2	—	—	—	5	14
ENSG00000294982	02-Medium	0.56	16.10	G1	C2	—	—	—	31	98
ENSG00000287507	02-Medium	0.56	15.71	G1	C2	—	—	—	0	0
LINC01678	02-Medium	0.56	22.45	G1	C2	—	—	68 cells — complete matches	2	2
ENSG00000237604	02-Medium	0.55	18.38	G1	C2	—	—	—	5	15
LINC00319	02-Medium	0.54	22.56	G1	C2	—	—	5 cells — complete matches	2	5
DNMT3L-AS1	02-Medium	0.53	22.12	G1	C2	—	—	—	6	15
RRP1	02-Medium	0.53	20.51	G1	C2	—	—	T.CD4_Treg.tissue_effector (L2), T.CD4_cytotoxic.baseline (L2), T.CD4_naive.survival_neddylation (L2)	1	1
TRAPPC10	02-Medium	0.52	26.75	G1	C2	—	—	18 cells — complete matches	4	5
ENSG00000300030	02-Medium	0.50	17.95	G1	C2	—	—	—	3	5
ENSG00000294141	02-Medium	0.50	26.75	G2	C2	—	—	—	3	6
ENSG00000275799	02-Medium	0.50	15.27	G1	C2	—	—	—	5	14
RRP1B	02-Medium	0.49	21.11	G2	C2	—	—	6 cells — complete matches	0	0
ENSG00000289546	02-Medium	0.48	16.11	G1	C2	—	—	—	1	1
LINC01679	02-Medium	0.48	21.56	G2	C2	—	—	56 cells — complete matches	3	5
CSTB	02-Medium	0.48	17.11	G1	C2	EPI.esophageal_basal.junctional_barrier (L2), EPI.tracheal_submucosal_gland.ductal_luminal (L2), GRNLSA.p53_damage (L2), MAC.MDM.LAM_like (L2), MAC.resident_iron.redox_metabolic (L2)	—	40 cells — complete matches	0	0
AIRE	02-Medium	0.47	25.73	G2	C2	EPI.thymic_medullary (L1S)	—	6 cells — complete matches	5	15
ENSG00000295592	02-Medium	0.47	21.93	G1	C2	—	—	—	0	0
ENSG00000310147	02-Medium	0.46	15.67	G1	C2	—	—	—	0	0
ENSG00000303490	02-Medium	0.46	21.13	G1	C2	—	—	—	0	0
ENSG00000309574	02-Medium	0.46	14.12	G1	C2	—	—	—	0	0
ENSG00000225637	02-Medium	0.45	15.13	G2	C2	—	—	—	0	0
CFAP410	02-Medium	0.44	11.18	G2	C2	—	—	—	6	30
DNMT3L	02-Medium	0.44	21.17	G2	C2	—	—	EPI.renal_proximal_tubule (L1S), EPI.renal_proximal_tubule.detox_antioxidant (L2), EPI.renal_proximal_tubule.onecarbon_peroxisome (L2)	5	14
LINC00322	02-Medium	0.44	19.63	G2	C2	—	—	MAC.LAM.lipid_phagocytosis (L2)	0	0
ENSG00000232969	02-Medium	0.43	9.30	G2	C2	—	—	—	3	12
H2BC12L	02-Medium	0.43	24.35	G2	C2	—	—	—	0	0
SH2B3	02-Medium	0.42	4.07	G1	C2	—	DC.cDC1.homeostatic_inhibitory (Tier: relevant)	47 cells — complete matches	316	770
ENSG00000257767	02-Medium	0.42	1.53	G1	C2	—	—	—	109	353
ATXN2	02-Medium	0.41	3.18	G1	C2	—	—	7 cells — complete matches	48	83
ENSG00000301935	02-Medium	0.41	16.40	G1	C2	—	—	—	2	4
PWP2	02-Medium	0.41	17.22	G1	C2	—	—	10 cells — complete matches	3	4
HSF2BP	02-Medium	0.41	11.91	G2	C2	—	—	4 cells — complete matches	0	0
GATD3	02-Medium	0.41	14.80	G2	C2	—	—	—	2	2
TMEM97P1	02-Medium	0.40	13.75	G2	C2	—	—	—	0	0
TRPM2	02-Medium	0.40	18.93	G2	C2	—	—	67 cells — complete matches	34	103
LINC02356	02-Medium	0.39	3.88	G1	C2	—	DC.cDC1.homeostatic_inhibitory (Tier: relevant)	28 cells — complete matches	263	733
PHETA1	02-Medium	0.39	3.63	G1	C2	—	—	—	228	664
TMPRSS3	02-Medium	0.38	9.78	G1	C2	—	—	53 cells — complete matches	19	52
ENSG00000298760	02-Medium	0.37	13.70	G2	C2	—	—	—	2	1
ENSG00000184441	02-Medium	0.36	10.59	G2	C2	—	—	—	3	12
SLC19A1	02-Medium	0.36	7.37	G1	C2	—	—	35 cells — complete matches	46	96
ENSG00000307048	02-Medium	0.36	7.53	G1	C2	—	—	—	24	48
HEPFAL	02-Medium	0.36	15.59	G2	C2	—	—	—	9	52
ENSG00000310337	02-Medium	0.36	17.08	G2	C2	—	—	—	0	0
ENSG00000308454	02-Medium	0.36	25.29	G2	C2	—	—	—	2	4
ENSG00000241728	02-Medium	0.35	9.30	G2	C2	—	—	—	3	12
SLX9	02-Medium	0.35	6.88	G2	C2	—	—	—	43	129
TSPEAR	02-Medium	0.34	10.41	G2	C2	—	—	EPI.pancreatic_islet (L1S), EPI.pancreatic_islet.beta (L2), EPI.pancreatic_islet.delta (L2)	7	26
LINC00334	02-Medium	0.34	6.22	G1	C2	—	EC.lymphatic.scavenger (Tier: relevant)	5 cells — complete matches	35	86
LRRC3	02-Medium	0.33	14.16	G2	C2	—	—	9 cells — complete matches	35	130
ENSG00000228120	02-Medium	0.33	14.45	G2	C2	—	—	—	10	11
ENSG00000280604	02-Medium	0.32	5.16	G1	C2	—	—	—	37	100
TRPM2-AS	02-Medium	0.31	11.67	G2	C2	—	—	6 cells — complete matches	10	39
GET1	02-Medium	0.31	3.78	G2	C2	—	—	—	1	4
LRRC3-DT	02-Medium	0.30	10.72	G2	C2	—	—	—	21	61
ATXN2-AS	02-Medium	0.29	3.12	G2	C2	—	EC.lymphatic.scavenger (Tier: relevant)	14 cells — complete matches	1	1
SH3BGR	02-Medium	0.28	5.43	G2	C2	—	—	12 cells — complete matches	3	6
ENSG00000225218	02-Medium	0.26	2.96	G2	C2	—	—	—	0	0
MX2	02-Medium	0.26	4.19	G2	C2	MESO.antiviral (L2)	—	51 cells — complete matches	12	17
ZBTB20	02-Medium	0.25	6.84	G2	C2	EPI.pancreatic_ductal_progenitor.ciliated_transport (L2), EPI.salivary_serous_acinar.quiescent (L2), NEU.INH_LAMP5.glial_interface (L2), NEU.INH_VIP.regulatory_remodeling (L2), PC.IgA_muocsal.migratory (L2), PERI.baseline (L2)	NEU.INH_LAMP5.glial_interface (Tier: relevant)	10 cells — complete matches	6	8
WDR4	02-Medium	0.23	5.42	G2	C2	—	—	8 cells — complete matches	0	0
ERVH48-1	02-Medium	0.22	5.24	G2	C2	—	—	11 cells — complete matches	0	0
NDUFV3	02-Medium	0.22	4.13	G2	C2	—	—	T.CD8_Tem.motility_primed (L2)	0	0
LINC02575	02-Medium	0.21	9.95	G2	C2	—	—	—	38	133
ZBTB20-AS5	02-Medium	0.19	5.92	G2	C2	—	—	10 cells — complete matches	1	1
TSPEAR-AS1	02-Medium	0.18	7.58	G2	C2	—	—	T.CD4_Tcm.synapse_dynamics (L2)	38	126

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.