Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90385168 · All tissues

DTI autoptx L2 atr l tract: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: White matter microstructure

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	17.46	Significant	3.30e-49	1.38	Relevant	0	0
2	natural_killer_cell	8.59	Significant	9.58e-40	1.33	Specific	1,204	2,052
3	haematopoietic_progenitor_cell	5.59	Significant	0.51	1.15	Other	262	502
4	endothelial_cell	5.29	Nominal	6.80e-11	1.15	Other	373	974
5	adipose_stem_and_progenitor_cell	2.81	Nonsignificant	1.00	1.00	Other	327	954
6	innate_lymphoid_cell_2	2.72	Nonsignificant	1.00	1.01	Other	3	8
7	platelet	2.16	Nonsignificant	—	0.42	Other	85	104
8	neuron	1.91	Nonsignificant	1.00	0.86	Other	330	1,328
9	cardiomyocyte	1.61	Nonsignificant	1.00	0.91	Other	533	2,045
10	muscle_stem_cell	1.61	Nonsignificant	1.00	0.89	Other	7	27
11	T_cell	1.38	Nonsignificant	1.00	0.85	Other	470	959
12	mesothelial_cell	0.91	Nonsignificant	1.00	0.85	Other	6	36
13	fibroblast	0.90	Nonsignificant	1.00	0.73	Other	184	826
14	monocyte	0.58	Nonsignificant	1.00	0.60	Other	2,176	3,871
15	oligodendrocyte_precursor_cell	0.51	Nonsignificant	1.00	0.62	Other	461	1,454
16	schwann_cell	0.51	Nonsignificant	1.00	0.77	Other	10	57
17	smooth_muscle_cell	0.23	Nonsignificant	1.00	0.54	Other	27	139
18	granulosa_cell	0.21	Nonsignificant	1.00	0.64	Other	293	670
19	dendritic_cell	0.17	Nonsignificant	1.00	0.58	Other	496	724
20	plasma_cell	0.17	Nonsignificant	1.00	0.47	Other	17	24
21	epithelial_cell	0.15	Nonsignificant	1.00	0.50	Other	24	47
22	melanocyte	0.14	Nonsignificant	1.00	0.51	Other	97	309
23	pericyte	0.13	Nonsignificant	1.00	0.50	Other	128	517
24	macrophage	0.10	Nonsignificant	1.00	0.52	Other	813	1,732
25	granulocyte	0.08	Nonsignificant	1.00	0.50	Other	5	6
26	thymocyte	0.07	Nonsignificant	1.00	0.48	Other	168	512
27	astrocyte	0.06	Nonsignificant	1.00	0.43	Other	256	1,203
28	B_cell	0.01	Nonsignificant	1.00	0.29	Other	356	694
29	adipocyte	0.01	Nonsignificant	1.00	0.41	Other	33	111
30	microglia	0.01	Nonsignificant	1.00	0.31	Other	61	129
31	chondrocyte	5.32e-03	Nonsignificant	1.00	0.24	Other	548	1,069
32	skeletal_muscle_cell	2.11e-03	Nonsignificant	1.00	0.25	Other	944	2,600
33	oligodendrocyte	1.62e-03	Nonsignificant	1.00	0.15	Other	385	1,507
34	hepatocyte	1.11e-03	Nonsignificant	1.00	0.17	Other	1,515	3,822

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	IPSC.induced_pluripotent_stem_cell	17.46	Significant	—	—	Relevant	0	0
2	NK.natural_killer_cell	8.59	Significant	—	—	Specific	1,204	2,045
3	EC.heart_remodeling	7.53	Significant	4.98e-05	1.51	Specific	569	1,594
4	EC.arterial	6.68	Significant	2.71e-03	1.32	Specific	356	885
5	EC.capillary	6.53	Significant	4.00e-07	1.50	Specific	514	1,635
6	HPC.haematopoietic_progenitor_cell	5.59	Significant	—	—	Other	211	370
7	T.CD8_Tem	5.41	Nominal	1.60e-49	1.96	Other	1,083	1,857
8	NEU.EXC_NTNG1	4.88	Nominal	—	1.63	Other	0	0
9	EC.liver_sinusoidal	4.02	Nominal	1.00	0.68	Other	1,083	1,925
10	T.CD4_cytotoxic	2.94	Nonsignificant	2.44e-03	1.41	Other	855	1,493
11	NEU.EXC_SYT2	2.85	Nonsignificant	—	0.60	Other	40	77
12	NEU.EXC_CT	2.81	Nonsignificant	0.29	1.26	Other	362	384
13	ASPC.adipose_stem_and_progenitor_cell	2.81	Nonsignificant	—	—	Other	324	930
14	EC.venous	2.79	Nonsignificant	1.00	0.06	Other	516	1,387
15	ILC2.innate_lymphoid_cell_2	2.72	Nonsignificant	—	—	Other	2	0
16	EPI.colonic_enteroendocrine	2.45	Nonsignificant	—	1.62	Other	1	1
17	PLAT.platelet	2.16	Nonsignificant	—	0.00	Other	38	53
18	FIB.neurolectin_mucosa	2.04	Nonsignificant	0.14	1.29	Other	133	394
19	FIB.barrier_secretory	2.03	Nonsignificant	0.83	1.13	Other	81	228
20	NEU.EXC_IT	1.92	Nonsignificant	0.01	1.43	Other	411	192
21	T.CD8_naive	1.79	Nonsignificant	8.95e-05	1.26	Other	317	708
22	T.CD8_transitional	1.79	Nonsignificant	0.22	1.11	Other	497	932
23	FIB.interstitial	1.73	Nonsignificant	5.34e-13	1.51	Other	288	940
24	T.CD8_Tcm	1.72	Nonsignificant	0.95	1.04	Other	460	926
25	T.gamma_delta	1.67	Nonsignificant	0.22	1.16	Other	588	1,078
26	CM.cardiomyocyte	1.61	Nonsignificant	—	—	Other	524	2,032
27	MUSC.muscle_stem_cell	1.61	Nonsignificant	—	—	Other	4	18
28	NEU.INH_VIP	1.54	Nonsignificant	0.98	0.73	Other	241	366
29	FIB.tracheal_subepithelial	1.51	Nonsignificant	—	0.72	Other	0	0
30	NEU.INH_PVALB	1.43	Nonsignificant	0.98	0.59	Other	193	183
31	FIB.reticular	1.38	Nonsignificant	0.83	1.04	Other	19	87
32	EC.lymphatic	1.29	Nonsignificant	1.00	0.03	Other	630	998
33	FIB.barrier_purinergic	1.27	Nonsignificant	—	0.51	Other	1	3
34	FIB.transitioning	1.25	Nonsignificant	0.83	1.03	Other	172	497
35	EPI.thymic_cortical	1.12	Nonsignificant	0.04	1.33	Other	442	824
36	EPI.cervical_suprabasal	1.04	Nonsignificant	—	1.88	Other	14	50
37	T.CD4_Th17	0.98	Nonsignificant	1.00	0.75	Other	421	794
38	NEU.INH_LAMP5	0.97	Nonsignificant	0.98	0.60	Other	263	532
39	MESO.mesothelial_cell	0.91	Nonsignificant	—	—	Other	2	18
40	MAC.alveolar	0.87	Nonsignificant	3.79e-03	1.16	Other	1,432	3,122
41	T.CD4_naive	0.85	Nonsignificant	1.00	0.63	Other	399	866
42	T.CD4_Tem	0.79	Nonsignificant	1.00	0.71	Other	365	697
43	T.MAIT	0.77	Nonsignificant	1.00	0.70	Other	469	855
44	EPI.renal_proximal_tubule	0.74	Nonsignificant	0.02	1.32	Other	525	806
45	T.CD8_Trm	0.64	Nonsignificant	1.00	0.53	Other	211	346
46	MONO.CD14	0.63	Nonsignificant	2.89e-07	1.27	Other	2,294	4,139
47	FIB.perivascular_interface	0.62	Nonsignificant	1.00	0.77	Other	0	0
48	FIB.skin_sheath	0.62	Nonsignificant	1.00	0.85	Other	49	118
49	EPI.salivary_duct_excretory	0.61	Nonsignificant	0.34	1.19	Other	85	180
50	EPI.lung_club_secretory	0.59	Nonsignificant	0.11	1.33	Other	5	14
51	OPC.oligodendrocyte_precursor_cell	0.51	Nonsignificant	—	—	Other	413	1,269
52	SCHWN.schwann_cell	0.51	Nonsignificant	—	—	Other	7	33
53	EPI.tracheal_basal	0.48	Nonsignificant	0.46	1.12	Other	398	1,120
54	EPI.colonic_tuft	0.48	Nonsignificant	—	1.29	Other	7	24
55	EPI.ileal_enterocyte_absorptive	0.47	Nonsignificant	0.37	1.13	Other	118	338
56	EPI.tracheal_suprabasal	0.47	Nonsignificant	1.00	1.06	Other	29	56
57	FIB.skin_papillary	0.47	Nonsignificant	—	0.07	Other	0	0
58	T.CD4_Tcm	0.47	Nonsignificant	1.00	0.31	Other	494	988
59	EPI.renal_distal_tubule	0.46	Nonsignificant	1.00	1.02	Other	133	361
60	EPI.endocervical_secretory	0.43	Nonsignificant	—	1.19	Other	0	0
61	EPI.renal_intercalated_cell_type_B	0.41	Nonsignificant	—	1.16	Other	6	7
62	EPI.intrahepatic_cholangiocyte_transport	0.38	Nonsignificant	—	0.61	Other	12	42
63	EPI.ileal_bile_transport	0.37	Nonsignificant	0.83	1.09	Other	61	93
64	FIB.skin_tenogenic	0.36	Nonsignificant	—	0.00	Other	108	227
65	FIB.skin_neurosecretory	0.36	Nonsignificant	—	0.00	Other	0	0
66	EPI.salivary_mucous_acinar	0.35	Nonsignificant	0.44	1.10	Other	639	1,189
67	EPI.renal_intercalated_cell_type_A	0.33	Nonsignificant	1.00	1.04	Other	67	142
68	MONO.CD16	0.30	Nonsignificant	1.00	0.72	Other	1,304	1,835
69	T.CD4_Th2	0.26	Nonsignificant	—	0.00	Other	1	2
70	EPI.salivary_intercalated_defense	0.26	Nonsignificant	1.00	0.98	Other	81	161
71	FIB.adventitial	0.26	Nonsignificant	1.00	0.67	Other	268	1,447
72	EPI.salivary_duct_ion_transport	0.24	Nonsignificant	1.00	0.99	Other	5	11
73	EPI.tracheal_submucosal_gland	0.23	Nonsignificant	—	0.75	Other	0	0
74	EPI.skin_keratinocyte_progenitor	0.23	Nonsignificant	—	0.77	Other	0	3
75	EPI.lung_multiciliated	0.23	Nonsignificant	1.00	1.00	Other	16	49
76	DC.cDC2	0.23	Nonsignificant	1.55e-03	1.18	Other	1,189	1,793
77	FIB.suburothelial	0.23	Nonsignificant	1.00	0.66	Other	122	432
78	SMC.smooth_muscle_cell	0.23	Nonsignificant	—	—	Other	20	101
79	GRNLSA.granulosa_cell	0.21	Nonsignificant	—	—	Other	257	0
80	EPI.skin_sebaceous_duct_luminal	0.20	Nonsignificant	1.00	0.97	Other	100	249
81	EPI.pancreatic_islet	0.20	Nonsignificant	0.74	1.13	Other	52	132
82	PC.IgG_systemic	0.19	Nonsignificant	0.66	1.08	Other	41	60
83	EPI.ileal_enterocyte_crypt	0.18	Nonsignificant	1.00	0.88	Other	67	113
84	T.CD4_transitional	0.17	Nonsignificant	1.00	0.16	Other	48	110
85	PC.IgA_muocsal	0.17	Nonsignificant	0.75	0.91	Other	18	31
86	FIB.lung_alveolar	0.16	Nonsignificant	—	0.00	Other	6	15
87	MAC.microglia_like	0.15	Nonsignificant	1.00	0.98	Other	124	179
88	MEL.melanocyte	0.14	Nonsignificant	—	—	Other	79	242
89	EPI.gastric_foveolar	0.14	Nonsignificant	—	0.59	Other	0	0
90	PERI.pericyte	0.13	Nonsignificant	—	—	Other	117	0
91	GRANU.MAST	0.13	Nonsignificant	4.69e-04	1.58	Other	5	6
92	EPI.renal_thick_ascending_limb	0.13	Nonsignificant	1.00	0.91	Other	453	1,153
93	EPI.skin_sweat_duct_keratinocyte	0.11	Nonsignificant	1.00	0.88	Other	146	301
94	EPI.pancreatic_acinar	0.11	Nonsignificant	1.00	0.97	Other	429	1,475
95	T.CD4_Trm	0.11	Nonsignificant	1.00	0.40	Other	176	363
96	EPI.skin_keratinocyte_proliferating	0.10	Nonsignificant	0.83	1.13	Other	47	76
97	HEP.pericentral_lipoprotein	0.09	Nonsignificant	—	2.64	Other	0	0
98	EPI.renal_principal_cell	0.08	Nonsignificant	1.00	0.80	Other	207	403
99	EPI.alveolar_type_1	0.07	Nonsignificant	1.00	0.77	Other	26	101
100	THYMO.thymocyte	0.07	Nonsignificant	—	—	Other	163	495
101	MAC.proliferating	0.07	Nonsignificant	1.00	0.93	Other	87	253
102	T.CD4_Tfh	0.06	Nonsignificant	1.00	0.07	Other	47	45
103	T.CD4_Treg	0.06	Nonsignificant	1.00	0.10	Other	244	511
104	EPI.pancreatic_ductal_mucinous	0.06	Nonsignificant	0.19	1.26	Other	219	430
105	ASTRO.astrocyte	0.06	Nonsignificant	—	—	Other	228	1,111
106	MAC.MDM	0.05	Nonsignificant	1.00	0.96	Other	623	986
107	B.age_associated	0.05	Nonsignificant	0.52	1.18	Other	207	350
108	MAC.resident_repair	0.05	Nonsignificant	1.00	0.96	Other	796	1,426
109	EPI.esophageal_basal	0.04	Nonsignificant	1.00	0.81	Other	4	10
110	EPI.ectocervical_granular	0.04	Nonsignificant	—	0.15	Other	11	23
111	B.germinal_center	0.04	Nonsignificant	0.57	1.11	Other	233	655
112	FIB.hepatic_stellate_cell	0.04	Nonsignificant	—	0.00	Other	64	252
113	MAC.resident_iron	0.03	Nonsignificant	1.00	0.90	Other	16	21
114	DC.mig	0.03	Nonsignificant	—	0.33	Other	89	156
115	EPI.bile_duct_cholangiocyte	0.03	Nonsignificant	1.00	0.85	Other	37	60
116	EPI.pancreatic_ductal_bicarbonate	0.03	Nonsignificant	1.00	0.74	Other	131	548
117	EPI.renal_immature_ureteric_bud	0.03	Nonsignificant	1.00	0.74	Other	217	569
118	MAC.LAM	0.02	Nonsignificant	1.00	0.85	Other	914	2,064
119	EPI.salivary_serous_acinar	0.02	Nonsignificant	1.00	0.73	Other	233	531
120	EPI.skin_hair_follicle_bulge	0.02	Nonsignificant	1.00	1.03	Other	51	178
121	B.memory	0.02	Nonsignificant	0.57	1.01	Other	442	882
122	EPI.intrahepatic_cholangiocyte_defense	0.02	Nonsignificant	—	0.00	Other	8	13
123	EPI.thymic_medullary	0.02	Nonsignificant	1.00	0.62	Other	26	133
124	EPI.skin_hair_follicle_companion	0.01	Nonsignificant	—	0.13	Other	8	12
125	ADIPO.adipocyte	0.01	Nonsignificant	—	—	Other	20	62
126	EPI.ileal_goblet	0.01	Nonsignificant	1.00	0.56	Other	181	432
127	MG.microglia	0.01	Nonsignificant	—	—	Other	49	0
128	MAC.kupffer	9.37e-03	Nonsignificant	1.00	0.78	Other	189	530
129	B.naive	7.18e-03	Nonsignificant	1.00	0.84	Other	307	595
130	EPI.hepatic_ductular_cholangiocyte	6.09e-03	Nonsignificant	1.00	0.52	Other	83	243
131	MAC.resident_cardiac	5.52e-03	Nonsignificant	1.00	0.64	Other	485	1,074
132	CHOND.chondrocyte	5.32e-03	Nonsignificant	—	—	Other	519	730
133	EPI.esophageal_suprabasal	4.99e-03	Nonsignificant	1.00	0.48	Other	158	404
134	EPI.skin_keratinocyte_basal	4.92e-03	Nonsignificant	—	0.00	Other	13	26
135	EPI.colonocyte	3.92e-03	Nonsignificant	1.00	0.47	Other	294	815
136	EPI.pancreatic_ductal_perivascular	3.64e-03	Nonsignificant	1.00	0.60	Other	4	30
137	SKM.type_2_fast	3.50e-03	Nonsignificant	7.79e-23	1.71	Other	972	2,639
138	EPI.skin_follicular_keratinizing	2.82e-03	Nonsignificant	1.00	0.43	Other	30	81
139	OLG.oligodendrocyte	1.62e-03	Nonsignificant	—	—	Other	384	1,397
140	DC.pDC	1.34e-03	Nonsignificant	1.00	0.36	Other	496	1,028
141	EPI.pancreatic_ductal_progenitor	1.18e-03	Nonsignificant	1.00	0.33	Other	234	873
142	HEP.periportal_metabolic	9.57e-04	Nonsignificant	8.84e-08	1.12	Other	1,750	4,427
143	HEP.canalicular_transport	9.55e-04	Nonsignificant	0.48	1.03	Other	1,290	3,434
144	EPI.skin_interfollicular_spinous	7.88e-04	Nonsignificant	1.00	0.30	Other	260	563
145	EPI.extrahepatic_cholangiocyte	6.51e-04	Nonsignificant	—	0.00	Other	37	71
146	DC.cDC1	4.00e-04	Nonsignificant	1.00	0.18	Other	55	112
147	EPI.skin_appendage_keratinocyte	3.45e-04	Nonsignificant	1.00	0.21	Other	87	222
148	EPI.salivary_myoepithelial	3.28e-04	Nonsignificant	1.00	0.23	Other	191	714
149	HEP.acute_phase	3.18e-04	Nonsignificant	0.94	0.89	Other	1,441	3,641
150	SKM.type_1_slow	2.45e-04	Nonsignificant	2.28e-20	1.68	Other	923	2,478
151	EPI.alveolar_type_2	1.52e-04	Nonsignificant	1.00	0.26	Other	813	1,853
152	GRANU.neutrophil	1.23e-04	Nonsignificant	1.00	0.00	Other	1,235	2,649

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	IPSC.mesenchymal_primed	40.72	Significant	6.89e-25	1.99	—	0	0
2	IPSC.midbrain_primed	39.29	Significant	2.47e-03	1.65	Relevant	0	0
3	IPSC.neural_primed	38.05	Significant	1.08e-07	1.72	—	0	0
4	IPSC.stress	29.28	Significant	0.08	1.40	Relevant	0	0
5	IPSC.stromal_primed	17.21	Significant	0.99	1.03	—	0	0
6	IPSC.neuroendocrine_primed	16.71	Significant	—	0.46	—	0	0
7	NK.immature_bridge	12.57	Significant	3.39e-06	2.48	—	117	122
8	EC.heart_remodeling.capillary_metabolic	11.70	Significant	0.17	1.55	Relevant	54	414
9	EC.arterial.metabolic	11.37	Significant	1.41e-03	1.72	—	195	159
10	IPSC.mesendo_primed	10.89	Significant	1.00	0.75	—	0	0
11	EC.heart_remodeling.angiocrine	10.20	Significant	0.17	1.31	Specific	182	525
12	NK.cytokine_biosynthetic_primed	10.16	Significant	0.10	1.61	—	360	21
13	NK.cytokine_vascular_patrolling	10.06	Significant	4.80e-03	1.86	—	863	94
14	EC.heart_remodeling.remodeling_secretory	9.86	Significant	0.02	1.62	Specific	605	1,341
15	HPC.MEP	9.71	Significant	0.24	1.48	Relevant	599	1,195
16	IPSC.axial_identity_primed	9.68	Significant	1.00	0.42	—	0	0
17	NK.cytokine_repair_primed	9.60	Significant	0.40	1.41	—	266	11
18	NK.cytokine_quiescent	9.48	Significant	0.10	1.53	Specific	623	1,062
19	NK.cytokine_axis_baseline	9.24	Significant	0.04	1.52	—	1,172	116
20	EC.capillary.angiocrine	9.00	Significant	9.50e-05	2.00	Specific	250	630
21	IPSC.proliferative	8.65	Significant	1.00	0.37	—	0	0
22	EC.arterial.elastic	8.47	Significant	0.32	1.34	—	22	45
23	NK.adaptive_HLAE_tuned	8.32	Significant	1.00	0.74	—	1,124	189
24	NK.adaptive_classII_inhibitory	8.27	Significant	1.00	0.80	—	880	154
25	MONO.CD14.cord_tolerance	8.11	Significant	1.55e-11	1.61	Specific	864	753
26	NK.adaptive_biosynthetic_primed	7.97	Significant	1.00	1.02	Relevant	244	405
27	NK.adaptive_axis_baseline	7.94	Significant	1.00	0.69	—	1,008	153
28	EC.capillary.postcap_venule	7.91	Significant	0.11	1.47	—	355	261
29	EC.arterial.inflammatory	7.75	Significant	0.68	1.11	—	63	50
30	T.CD8_Tem.TEMRA	7.66	Significant	2.73e-09	2.56	Specific	920	1,088
31	T.CD8_Tcm.NK_like	7.44	Significant	3.94e-06	1.79	Specific	334	581
32	EC.arterial.mito_contact	7.43	Significant	0.56	1.24	Other	14	5
33	EC.capillary.migratory	7.26	Significant	0.30	1.34	Relevant	181	509
34	EPI.colonic_enteroendocrine.progenitor	6.91	Significant	—	0.97	Relevant	0	0
35	EC.liver_sinusoidal.stress	6.68	Significant	—	1.38	Relevant	413	158
36	NK.adaptive_adipose_stress	6.56	Significant	1.00	0.41	—	374	39
37	NK.cytokine_tissue_activation	6.49	Significant	1.00	0.62	Relevant	267	450
38	HPC.LMPP	6.42	Significant	0.46	1.12	Relevant	65	31
39	EC.capillary.baseline	6.28	Significant	0.85	1.03	Specific	246	560
40	EC.capillary.stress	6.24	Significant	1.00	0.76	Relevant	44	36
41	T.CD8_Tem.signaling_turnover	6.12	Significant	0.41	1.35	Specific	425	683
42	HPC.MPP_IEG	6.08	Significant	0.46	1.14	Relevant	45	46
43	T.CD8_Tem.motility_primed	5.83	Significant	0.81	1.07	Relevant	269	4
44	FIB.adventitial.activated_remodelling	5.78	Significant	—	2.46	Other	141	319
45	NK.adaptive_immature_precursor	5.73	Significant	1.00	0.22	—	358	111
46	NEU.EXC_NTNG1.nuclear_reg	5.68	Significant	—	0.67	Relevant	0	0
47	EC.liver_sinusoidal.remodeling_lipotoxicity	5.64	Significant	—	0.88	Relevant	90	58
48	EC.venous.quiescent_homeostatic	5.56	Significant	0.03	1.52	Other	456	360
49	EC.arterial.arteriole_interface	5.50	Nominal	1.00	0.77	Other	31	12
50	NEU.EXC_SYT2.nuclear_reg	5.45	Nominal	—	0.97	Relevant	0	0
51	ASPC.remodeling	5.44	Nominal	2.37e-08	2.42	Other	106	354
52	EC.liver_sinusoidal.inflammatory	5.27	Nominal	—	0.56	Other	223	154
53	EC.arterial.arteriole_gas_exchange	5.12	Nominal	1.00	0.62	Other	238	131
54	T.CD8_Tem.early_helper_like	5.12	Nominal	0.91	0.92	Other	445	755
55	ILC2.activated	5.12	Nominal	—	0.00	Other	0	0
56	EC.capillary.angiogenic_tip	5.08	Nominal	1.00	0.57	Other	186	218
57	PLAT.megakaryocytic	5.04	Nominal	—	0.97	Other	0	0
58	EC.heart_remodeling.activated_acute	4.93	Nominal	1.00	0.48	Other	102	186
59	EC.venous.cardiac_structural	4.91	Nominal	8.23e-03	1.81	Other	102	229
60	NEU.EXC_CT.Ca2_sensor	4.85	Nominal	—	1.59	Other	0	0
61	T.CD8_Tem.stress_adapted	4.79	Nominal	1.00	0.30	Other	607	520
62	EC.venous.adipose_lipid	4.58	Nominal	0.10	1.43	Other	254	476
63	ASPC.inflammatory	4.55	Nominal	0.05	1.73	Other	21	61
64	EC.arterial.homeostatic	4.40	Nominal	1.00	0.40	Other	24	3
65	EC.capillary.activated	4.27	Nominal	1.00	0.53	Other	2	5
66	EC.capillary.inflammatory	4.25	Nominal	1.00	0.12	Other	27	51
67	T.CD8_Tem.baseline	4.20	Nominal	1.00	0.07	Other	458	356
68	NEU.EXC_CT.Ca2_signaling	4.07	Nominal	—	0.79	Other	68	17
69	NK.cytokine_tissue_resident	3.97	Nominal	1.00	0.02	Other	74	82
70	NEU.EXC_NTNG1.synaptic	3.96	Nominal	—	0.00	Other	0	0
71	IPSC.endoderm_primed	3.94	Nominal	1.00	0.09	Other	0	0
72	NK.adaptive_terminal_cytotoxic	3.93	Nominal	1.00	0.08	Other	485	802
73	EC.arterial.ion_pump	3.80	Nominal	1.00	0.43	Other	3	2
74	NK.cytokine_lung_immediate_early	3.74	Nominal	1.00	0.01	Other	424	274
75	EC.venous.remodeling_stalk	3.72	Nominal	0.22	1.30	Other	559	566
76	EC.heart_remodeling.translation_boost	3.69	Nominal	—	0.00	Other	0	0
77	NEU.EXC_IT.structural	3.66	Nominal	0.06	1.39	Other	171	41
78	T.CD4_cytotoxic.terminal_effector	3.64	Nominal	0.21	1.52	Other	286	21
79	EC.heart_remodeling.remodeling_stalk	3.62	Nominal	1.00	0.31	Other	33	111
80	EC.arterial.angiogenic_tip	3.41	Nominal	—	0.00	Other	30	37
81	ASPC.proliferative	3.35	Nominal	0.43	1.31	Other	33	85
82	ASPC.activated	3.29	Nominal	0.18	1.39	Other	164	162
83	EC.liver_sinusoidal.secretory_lipoprotein	3.26	Nominal	1.00	0.81	Other	120	70
84	IPSC.canonical_pluripotent	3.24	Nominal	1.00	0.00	Other	0	0
85	HPC.MPP_activated	3.13	Nominal	—	0.00	Other	0	0
86	ASPC.baseline	3.13	Nominal	0.25	1.21	Other	363	170
87	T.CD4_cytotoxic.NK_adapted	2.99	Nonsignificant	0.40	1.34	Other	82	33
88	ASPC.preadipocyte_lipid_primed	2.87	Nonsignificant	0.43	1.12	Other	331	129
89	EC.liver_sinusoidal.hypoxia_metabolic	2.82	Nonsignificant	1.00	0.10	Other	183	107
90	HPC.GMP_inflammatory	2.80	Nonsignificant	0.94	0.51	Other	20	10
91	FIB.interstitial.mesenchymal_APC	2.79	Nonsignificant	0.01	1.72	Other	81	33
92	FIB.interstitial.stress_secretory	2.77	Nonsignificant	0.03	1.84	Other	92	56
93	NEU.EXC_IT.callosal	2.72	Nonsignificant	0.81	1.09	Other	286	119
94	EC.heart_remodeling.perivascular	2.62	Nonsignificant	1.00	0.00	Other	124	408
95	T.CD8_transitional.effector_primed	2.62	Nonsignificant	4.70e-05	1.77	Other	435	151
96	NEU.INH_PVALB.chandelier	2.58	Nonsignificant	2.34e-04	2.34	Other	19	16
97	FIB.reticular.stress_metallothionein	2.54	Nonsignificant	—	0.79	Other	3	32
98	EPI.lung_club_secretory.ciliogenesis_axoneme	2.52	Nonsignificant	—	1.13	Other	0	0
99	T.CD4_cytotoxic.baseline	2.47	Nonsignificant	0.97	0.65	Other	0	0
100	EC.liver_sinusoidal.prostanoid	2.47	Nonsignificant	—	0.00	Other	11	64
101	ASPC.adipocyte_capillary_interface	2.43	Nonsignificant	1.00	0.60	Other	21	54
102	NEU.EXC_CT.remodeling	2.35	Nonsignificant	—	0.00	Other	23	1
103	FIB.barrier_secretory.remodeling	2.34	Nonsignificant	—	0.00	Other	0	0
104	NEU.INH_VIP.serotonergic	2.33	Nonsignificant	—	0.90	Other	9	2
105	EC.venous.baseline	2.31	Nonsignificant	1.00	0.55	Other	346	807
106	FIB.neurolectin_mucosa.nerve_interface	2.29	Nonsignificant	—	0.00	Other	4	0
107	HPC.GMP_granulocytic	2.22	Nonsignificant	—	0.00	Other	3	3
108	T.CD4_cytotoxic.activated	2.22	Nonsignificant	0.97	0.40	Other	3	1
109	NEU.EXC_IT.guidance	2.20	Nonsignificant	1.00	0.97	Other	274	63
110	T.CD8_naive.mito_proteostasis	2.20	Nonsignificant	0.11	1.63	Other	428	100
111	MUSC.activated_migratory	2.17	Nonsignificant	2.58e-03	2.57	Other	6	7
112	ASPC.stem_like_progenitor	2.14	Nonsignificant	1.00	0.67	Other	300	842
113	T.CD8_naive.innate_like	2.10	Nonsignificant	0.11	1.75	Other	10	1
114	NEU.INH_VIP.nuclear_reg	2.10	Nonsignificant	—	0.76	Other	20	4
115	T.gamma_delta.cytotoxic_effector	2.09	Nonsignificant	6.77e-04	2.00	Other	349	109
116	FIB.neurolectin_mucosa.inflammatory	2.04	Nonsignificant	0.57	1.26	Other	52	110
117	T.CD8_Tcm.gut_homing	2.01	Nonsignificant	0.12	1.37	Other	380	112
118	T.CD8_naive.vesicle_secretory	2.00	Nonsignificant	0.41	1.24	Other	42	0
119	EC.lymphatic.tip_migratory	1.98	Nonsignificant	0.51	1.35	Other	23	37
120	FIB.neurolectin_mucosa.remodeling_repair	1.97	Nonsignificant	—	0.08	Other	4	2
121	FIB.interstitial.lipid_matrix	1.95	Nonsignificant	0.22	1.29	Other	258	191
122	CM.oxidative_phospho	1.95	Nonsignificant	0.32	1.54	Other	266	792
123	NEU.EXC_CT.projector	1.94	Nonsignificant	1.00	0.00	Other	87	26
124	ILC2.quiescent	1.93	Nonsignificant	—	0.00	Other	0	0
125	FIB.neurolectin_mucosa.axon_responsive	1.91	Nonsignificant	0.78	0.62	Other	10	10
126	NEU.INH_VIP.cannabinoid	1.89	Nonsignificant	—	0.41	Other	0	0
127	FIB.barrier_purinergic.stress_GF_binding	1.88	Nonsignificant	—	0.97	Other	0	0
128	T.CD4_cytotoxic.precursor	1.84	Nonsignificant	0.97	0.61	Other	156	67
129	NEU.INH_VIP.matrix	1.81	Nonsignificant	—	0.41	Other	24	77
130	T.CD8_naive.cytokine_dampened	1.81	Nonsignificant	0.41	1.16	Other	71	4
131	FIB.barrier_secretory.homeostasis	1.80	Nonsignificant	—	0.00	Other	0	0
132	EC.lymphatic.activated	1.80	Nonsignificant	0.69	1.13	Other	47	73
133	CM.mito_proteostasis	1.79	Nonsignificant	0.50	1.34	Other	329	29
134	T.CD8_naive.splicing_enriched	1.78	Nonsignificant	0.97	0.80	Other	120	16
135	T.CD8_naive.baseline	1.76	Nonsignificant	0.97	0.78	Other	142	2
136	T.CD8_naive.nfkb_related	1.75	Nonsignificant	0.36	1.34	Other	1	0
137	CM.sarcomere_actin_interface	1.71	Nonsignificant	0.81	1.15	Other	450	78
138	DC.cDC2.lipid_metabolic	1.70	Nonsignificant	—	1.31	Other	0	0
139	NEU.INH_VIP.opioid	1.68	Nonsignificant	—	0.26	Other	50	9
140	MAC.alveolar.capillary_interacting	1.67	Nonsignificant	0.10	1.66	Other	113	181
141	NEU.INH_VIP.canonical_disinhibitory	1.67	Nonsignificant	0.49	1.04	Other	59	38
142	T.CD8_transitional.APC_like	1.65	Nonsignificant	0.86	0.93	Other	205	62
143	NEU.INH_PVALB.metabotropic	1.63	Nonsignificant	—	0.21	Other	0	0
144	CM.baseline	1.63	Nonsignificant	0.81	1.07	Other	393	0
145	ASPC.niche_keeping_progenitor	1.62	Nonsignificant	1.00	0.17	Other	52	219
146	MONO.CD14.inflammatory	1.62	Nonsignificant	0.24	1.42	Other	92	134
147	T.CD4_Tem.cytotoxic_effector	1.61	Nonsignificant	8.03e-04	1.52	Other	225	398
148	IPSC.mesodermal_primed	1.60	Nonsignificant	1.00	0.08	Other	0	0
149	T.CD8_transitional.Trm_primed	1.60	Nonsignificant	0.81	1.06	Other	108	15
150	ASPC.secretory	1.58	Nonsignificant	1.00	0.07	Other	76	5
151	CM.anti_inflammatory	1.57	Nonsignificant	0.81	1.06	Other	424	1,503
152	T.gamma_delta.early_effector	1.56	Nonsignificant	0.99	0.80	Other	89	0
153	T.CD8_naive.effector_transition	1.55	Nonsignificant	0.97	0.57	Other	35	62
154	EC.venous.activated	1.53	Nonsignificant	1.00	0.58	Other	247	752
155	MUSC.baseline	1.51	Nonsignificant	0.85	0.65	Other	0	0
156	CM.translation_boost_RPS	1.51	Nonsignificant	1.00	0.72	Other	69	16
157	FIB.interstitial.immune_interact	1.51	Nonsignificant	1.00	0.63	Other	12	1
158	T.CD8_naive.lipid_synthesis	1.51	Nonsignificant	0.77	1.00	Other	6	4
159	FIB.tracheal_subepithelial.baseline	1.51	Nonsignificant	—	0.00	Other	0	0
160	CM.translation_boost_RPL	1.51	Nonsignificant	1.00	0.78	Other	129	1
161	FIB.transitioning.secretory_procollagen	1.50	Nonsignificant	—	0.61	Other	0	0
162	EPI.cervical_suprabasal.secretory_vesicle	1.48	Nonsignificant	—	0.73	Other	0	0
163	MUSC.early_activation	1.46	Nonsignificant	0.85	0.74	Other	4	32
164	SCHWN.reactive_inflammatory	1.43	Nonsignificant	—	1.14	Other	0	0
165	FIB.reticular.immune_interface	1.42	Nonsignificant	—	0.10	Other	1	6
166	MUSC.quiescent_reservoir	1.40	Nonsignificant	0.85	0.45	Other	2	8
167	CM.osmoprotection	1.40	Nonsignificant	1.00	0.57	Other	34	57
168	FIB.reticular.ECM_builder	1.40	Nonsignificant	—	0.18	Other	0	0
169	CM.inflammatory	1.39	Nonsignificant	—	0.00	Other	0	0
170	T.CD8_transitional.early	1.38	Nonsignificant	0.99	0.56	Other	327	55
171	T.gamma_delta.central_memory	1.36	Nonsignificant	0.99	0.38	Other	460	919
172	FIB.transitioning.ISG_primed_interface	1.36	Nonsignificant	—	0.27	Other	17	80
173	T.CD8_Tcm.baseline	1.30	Nonsignificant	1.00	0.71	Other	90	89
174	MESO.baseline	1.30	Nonsignificant	0.23	1.22	Other	0	6
175	T.CD4_Th17.migratory	1.28	Nonsignificant	0.48	1.15	Other	13	23
176	NEU.INH_PVALB.serotonergic	1.26	Nonsignificant	—	0.00	Other	0	0
177	T.CD4_Tcm.Th2_like	1.26	Nonsignificant	0.21	1.51	Other	23	55
178	MONO.CD14.repair_M2_like	1.25	Nonsignificant	0.52	1.13	Other	550	1,495
179	EPI.thymic_cortical.baseline	1.25	Nonsignificant	8.44e-03	2.48	Other	185	386
180	NEU.EXC_SYT2.synaptic	1.23	Nonsignificant	—	0.00	Other	0	0
181	NEU.INH_LAMP5.exc_inh_balance	1.21	Nonsignificant	—	0.71	Other	46	2
182	ASPC.mesothelial_like	1.18	Nonsignificant	1.00	0.61	Other	143	486
183	EPI.thymic_cortical.Notch_interface	1.18	Nonsignificant	—	0.00	Other	82	137
184	FIB.transitioning.motility_remodelling	1.15	Nonsignificant	—	0.00	Other	0	0
185	FIB.interstitial.remodeling	1.15	Nonsignificant	1.00	0.21	Other	31	9
186	ILC2.migratory	1.14	Nonsignificant	—	6.94e-17	Other	0	0
187	NEU.INH_VIP.excitatory_coupled	1.13	Nonsignificant	—	0.00	Other	13	0
188	CM.mechano_activated	1.12	Nonsignificant	1.00	0.51	Other	205	134
189	EPI.renal_distal_tubule.repair	1.10	Nonsignificant	—	0.64	Other	34	102
190	NEU.EXC_IT.neuromodulated	1.10	Nonsignificant	1.00	0.59	Other	176	116
191	T.CD4_naive.survival_mitoprot	1.10	Nonsignificant	0.45	1.34	Other	13	7
192	T.CD8_Tcm.effector_bias	1.09	Nonsignificant	1.00	0.74	Other	199	329
193	T.CD8_transitional.stress	1.09	Nonsignificant	—	0.00	Other	24	34
194	NEU.INH_VIP.develop_niche	1.06	Nonsignificant	—	0.00	Other	0	0
195	MESO.antiviral	1.05	Nonsignificant	—	0.00	Other	3	8
196	MAC.alveolar.inflammatory	1.04	Nonsignificant	0.25	1.36	Other	208	312
197	FIB.transitioning.matrix_stress	1.03	Nonsignificant	—	0.00	Other	47	138
198	T.CD4_naive.neddylation_mitoprot	1.03	Nonsignificant	0.73	1.15	Other	93	56
199	EC.lymphatic.baseline	1.02	Nonsignificant	0.74	0.97	Other	38	72
200	NEU.INH_PVALB.nuclear_reg	1.02	Nonsignificant	0.75	0.69	Other	25	12
201	T.CD4_naive.purinergic	1.00	Nonsignificant	0.91	1.06	Other	49	1
202	T.CD4_Th17.baseline	0.97	Nonsignificant	0.17	1.43	Other	51	5
203	T.CD4_naive.gut_prone	0.96	Nonsignificant	0.45	1.44	Other	35	70
204	T.CD4_naive.homeostatic	0.95	Nonsignificant	0.31	1.27	Other	215	108
205	NEU.INH_LAMP5.glial_interface	0.95	Nonsignificant	—	0.18	Other	0	0
206	GRNLSA.EMT_insulin_signaling	0.92	Nonsignificant	0.48	1.18	Other	47	84
207	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.90	Nonsignificant	—	0.73	Other	0	0
208	FIB.reticular.stromal_niche	0.89	Nonsignificant	0.84	0.61	Other	0	0
209	T.CD4_naive.survival	0.88	Nonsignificant	0.91	1.08	Other	12	17
210	T.MAIT.quiescent	0.88	Nonsignificant	0.38	1.46	Other	100	5
211	T.MAIT.vesicle	0.88	Nonsignificant	0.86	0.88	Other	37	65
212	T.CD4_naive.mature	0.87	Nonsignificant	1.00	0.93	Other	211	100
213	T.MAIT.cytotoxic	0.87	Nonsignificant	0.86	1.15	Other	52	15
214	T.CD4_naive.mature_mitoprot	0.85	Nonsignificant	0.91	1.03	Other	212	476
215	FIB.perivascular_interface.lipid_shuttle	0.84	Nonsignificant	—	0.30	Other	51	170
216	NEU.INH_PVALB.neuromodulatory	0.83	Nonsignificant	—	0.00	Other	0	0
217	DC.cDC2.monocyte_like	0.83	Nonsignificant	0.51	1.17	Other	1,285	791
218	EPI.thymic_cortical.secretory_remodeling	0.83	Nonsignificant	—	0.00	Other	4	1
219	MAC.alveolar.scavenging_endocytic	0.81	Nonsignificant	—	0.03	Other	140	283
220	SCHWN.translation_boost	0.81	Nonsignificant	—	0.62	Other	8	1
221	T.MAIT.early_activation	0.81	Nonsignificant	0.86	1.00	Other	57	4
222	EPI.renal_distal_tubule.ciliated_remodelling	0.80	Nonsignificant	—	1.04	Other	0	0
223	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.80	Nonsignificant	—	0.74	Other	19	54
224	MESO.activated_migratory	0.78	Nonsignificant	—	0.00	Other	0	0
225	FIB.barrier_purinergic.lipid_secretory	0.78	Nonsignificant	—	0.00	Other	0	0
226	T.CD4_naive.resist_bystander	0.78	Nonsignificant	1.00	0.86	Other	40	25
227	EPI.renal_proximal_tubule.detox_antioxidant	0.77	Nonsignificant	0.22	1.71	Other	394	77
228	NEU.INH_LAMP5.projecting	0.76	Nonsignificant	—	0.00	Other	0	0
229	MAC.alveolar.lipid_autophagy	0.76	Nonsignificant	—	0.00	Other	35	44
230	FIB.skin_sheath.ECM_immune	0.76	Nonsignificant	—	0.35	Other	0	0
231	T.CD4_naive.neddylation	0.76	Nonsignificant	1.00	0.70	Other	104	222
232	T.CD8_Trm.dendritic_recruiter	0.75	Nonsignificant	0.56	1.11	Other	47	85
233	T.CD4_Tem.long_term_memory	0.75	Nonsignificant	0.61	1.09	Other	314	587
234	T.MAIT.MAPK_brake	0.75	Nonsignificant	0.86	0.82	Other	44	66
235	T.CD8_Trm.cytotoxic	0.75	Nonsignificant	0.25	1.28	Other	165	85
236	T.CD8_Trm.homeostatic	0.74	Nonsignificant	0.25	1.23	Other	42	5
237	FIB.interstitial.mesenchymal_regulator	0.74	Nonsignificant	1.00	0.06	Other	4	4
238	T.CD4_Th17.cytotoxic	0.71	Nonsignificant	0.89	0.65	Other	332	123
239	ASPC.signal_integrator	0.70	Nonsignificant	—	0.00	Other	0	0
240	CM.contractile_oxphos	0.70	Nonsignificant	1.00	0.07	Other	6	19
241	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.70	Nonsignificant	0.93	0.24	Other	58	89
242	NEU.INH_LAMP5.rosehip	0.69	Nonsignificant	—	0.00	Other	0	0
243	EPI.salivary_duct_excretory.baseline	0.67	Nonsignificant	9.44e-03	2.12	Other	23	57
244	T.CD4_Tcm.synapse_dynamics	0.66	Nonsignificant	0.94	1.23	Other	15	10
245	NEU.INH_PVALB.fastspike	0.66	Nonsignificant	—	0.00	Other	24	22
246	NEU.INH_VIP.regulatory_remodeling	0.65	Nonsignificant	—	0.00	Other	6	1
247	EPI.ileal_enterocyte_absorptive.brush_border	0.65	Nonsignificant	3.81e-07	2.73	Other	580	1,717
248	OPC.proliferative_immune_interact	0.65	Nonsignificant	0.18	1.52	Other	180	373
249	EPI.tracheal_suprabasal.transitional_wound	0.63	Nonsignificant	—	0.60	Other	16	1
250	T.CD4_naive.survival_neddylation	0.62	Nonsignificant	1.00	0.78	Other	26	38
251	FIB.perivascular_interface.vasomotor_tone	0.60	Nonsignificant	—	0.32	Other	0	0
252	EPI.cervical_suprabasal.inflammatory_repair	0.59	Nonsignificant	—	0.00	Other	0	0
253	NEU.INH_VIP.LAMP5_hybrid	0.59	Nonsignificant	—	0.00	Other	1	9
254	OPC.premyelinating	0.59	Nonsignificant	0.37	1.23	Other	185	12
255	MONO.CD16.platelet_bound	0.58	Nonsignificant	0.22	1.36	Other	372	508
256	T.CD4_naive.proteostasis_mitoprot	0.58	Nonsignificant	1.00	0.55	Other	15	37
257	FIB.skin_sheath.neuro_vascular_interface	0.57	Nonsignificant	—	6.94e-17	Other	0	0
258	MAC.alveolar.biosynthetic_sterol_heme	0.56	Nonsignificant	0.98	0.43	Other	347	40
259	T.CD4_Tcm.imprinted_splicing	0.56	Nonsignificant	0.94	1.03	Other	6	17
260	EC.lymphatic.scavenger	0.56	Nonsignificant	1.00	0.16	Other	203	257
261	T.CD4_Tcm.tissue_homing	0.55	Nonsignificant	0.94	1.09	Other	78	46
262	T.CD4_naive.proteostasis	0.54	Nonsignificant	1.00	0.47	Other	14	9
263	T.CD4_Tcm.effector_like	0.54	Nonsignificant	0.94	1.11	Other	293	533
264	EPI.tracheal_basal.homeostatic_progenitor	0.53	Nonsignificant	0.33	1.54	Other	285	74
265	T.CD4_Tcm.RNA_control	0.53	Nonsignificant	0.94	1.03	Other	96	4
266	FIB.skin_sheath.stress_chaperone	0.52	Nonsignificant	—	0.00	Other	0	0
267	MEL.dedifferentiated_migratory	0.52	Nonsignificant	—	0.83	Other	0	0
268	T.CD8_Trm.muscosal_Tc17	0.52	Nonsignificant	0.63	0.99	Other	19	38
269	EPI.colonic_tuft.homeostatic	0.51	Nonsignificant	—	0.42	Other	0	0
270	EC.lymphatic.valve	0.50	Nonsignificant	—	0.00	Other	0	0
271	T.CD4_Tcm.secretory	0.50	Nonsignificant	0.94	0.89	Other	20	11
272	T.MAIT.migratory	0.48	Nonsignificant	0.99	0.37	Other	10	1
273	MESO.secretory_structural	0.48	Nonsignificant	—	0.00	Other	0	0
274	PLAT.adhesion	0.48	Nonsignificant	—	0.00	Other	0	0
275	T.CD4_Tcm.crosstalk_myeloid	0.48	Nonsignificant	0.94	0.90	Other	5	4
276	EPI.salivary_duct_excretory.stress	0.48	Nonsignificant	0.85	0.47	Other	33	68
277	FIB.skin_papillary.baseline	0.47	Nonsignificant	—	0.00	Other	0	0
278	T.CD4_Tcm.regulatory_poised	0.47	Nonsignificant	0.94	0.86	Other	2	3
279	T.CD4_Tcm.retro_ZNF117	0.46	Nonsignificant	0.94	0.84	Other	5	9
280	MONO.CD14.remodeling	0.46	Nonsignificant	1.00	0.83	Other	2,373	295
281	GRNLSA.proliferative_migratory	0.45	Nonsignificant	0.48	1.11	Other	248	292
282	EPI.endocervical_secretory.secretory_translocon	0.45	Nonsignificant	—	0.67	Other	0	0
283	EPI.colonic_tuft.activated	0.44	Nonsignificant	—	0.00	Other	0	0
284	T.CD4_Tcm.DC_interact	0.44	Nonsignificant	0.94	0.95	Other	72	32
285	T.CD4_Tcm.stress	0.43	Nonsignificant	0.94	0.88	Other	5	11
286	MAC.microglia_like.patrolling_adhesive	0.43	Nonsignificant	—	1.21	Other	0	0
287	FIB.adventitial.PI16_matrix	0.42	Nonsignificant	0.59	1.18	Other	70	90
288	T.CD8_Tcm.helper_like	0.41	Nonsignificant	1.00	0.04	Other	81	159
289	EPI.renal_intercalated_cell_type_B.baseline	0.41	Nonsignificant	—	0.00	Other	3	1
290	T.CD4_Th2.precursor	0.41	Nonsignificant	—	0.48	Other	0	0
291	EPI.tracheal_basal.activated_stress	0.40	Nonsignificant	0.94	0.30	Other	32	0
292	MONO.CD14.baseline	0.40	Nonsignificant	1.00	0.65	Other	2,268	76
293	T.CD8_Trm.inflammatory	0.40	Nonsignificant	1.00	0.49	Other	124	176
294	EPI.pancreatic_islet.beta	0.40	Nonsignificant	0.14	1.28	Other	42	57
295	EPI.ileal_bile_transport.absorptive_xenobiotic	0.40	Nonsignificant	6.58e-03	2.67	Other	11	12
296	HPC.CLP_B_primed	0.40	Nonsignificant	—	0.00	Other	0	0
297	FIB.perivascular_interface.vascular_BM_remodelling	0.39	Nonsignificant	—	0.00	Other	0	0
298	MAC.alveolar.stress_metabolic	0.39	Nonsignificant	0.98	0.26	Other	116	148
299	FIB.adventitial.adhesion_lipid	0.38	Nonsignificant	0.59	1.33	Other	58	209
300	EPI.endocervical_secretory.squamous_barrier	0.38	Nonsignificant	—	0.00	Other	0	0
301	T.CD4_Tem.inflammatory	0.38	Nonsignificant	1.00	0.58	Other	28	6
302	MEL.neurotrophic_migratory	0.38	Nonsignificant	—	0.85	Other	0	0
303	FIB.skin_tenogenic.baseline	0.36	Nonsignificant	—	0.00	Other	0	2
304	FIB.skin_neurosecretory.baseline	0.36	Nonsignificant	—	0.00	Other	0	0
305	EPI.renal_intercalated_cell_type_A.PC_transitional	0.36	Nonsignificant	—	0.00	Other	203	407
306	PC.IgG_systemic.interacting	0.36	Nonsignificant	0.97	0.99	Other	0	0
307	EPI.pancreatic_acinar.stress	0.36	Nonsignificant	0.55	1.12	Other	28	28
308	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.35	Nonsignificant	—	1.36	Other	0	0
309	EPI.salivary_mucous_acinar.baseline	0.35	Nonsignificant	—	—	Other	394	683
310	OPC.homeostatic	0.35	Nonsignificant	0.86	0.65	Other	394	160
311	PC.IgG_systemic.stress	0.34	Nonsignificant	—	0.95	Other	1	5
312	NEU.EXC_IT.transitional	0.34	Nonsignificant	1.00	0.52	Other	237	142
313	EPI.skin_keratinocyte_proliferating.detox_repair	0.34	Nonsignificant	—	0.92	Other	0	0
314	SMC.activated	0.34	Nonsignificant	0.21	1.29	Other	2	5
315	MONO.CD14.platelet_bound	0.34	Nonsignificant	1.00	0.77	Other	964	176
316	MESO.activated_stress	0.34	Nonsignificant	—	0.00	Other	0	0
317	MONO.CD16.patrolling	0.33	Nonsignificant	0.22	1.19	Other	797	216
318	MONO.CD16.inflammatory	0.33	Nonsignificant	0.27	1.14	Other	1,640	168
319	T.CD4_Tcm.migratory_cilium	0.33	Nonsignificant	1.00	0.64	Other	5	10
320	THYMO.proliferative_S	0.33	Nonsignificant	0.22	1.12	Other	163	418
321	EPI.renal_intercalated_cell_type_A.acid_secretion	0.32	Nonsignificant	0.49	0.97	Other	12	6
322	EPI.skin_keratinocyte_progenitor.activated_stress	0.32	Nonsignificant	—	0.38	Other	0	0
323	T.MAIT.stress	0.32	Nonsignificant	—	0.00	Other	0	0
324	EPI.pancreatic_acinar.quiet_dedifferentiation	0.32	Nonsignificant	0.75	1.03	Other	142	171
325	T.CD4_Tcm.Tfh_like	0.31	Nonsignificant	0.94	1.06	Other	102	214
326	NEU.INH_VIP.enkephalinergic	0.31	Nonsignificant	—	0.00	Other	0	0
327	PERI.inflammatory	0.31	Nonsignificant	6.88e-03	1.26	Other	40	77
328	EPI.ileal_bile_transport.detox_transcytosis	0.30	Nonsignificant	—	0.00	Other	0	1
329	MAC.MDM.LAM_like	0.29	Nonsignificant	0.38	1.21	Other	12	14
330	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.29	Nonsignificant	—	0.81	Other	0	0
331	EPI.colonic_enteroendocrine.Lcell_peptide	0.29	Nonsignificant	—	0.00	Other	0	0
332	EPI.alveolar_type_1.activated	0.29	Nonsignificant	—	1.64	Other	0	0
333	EPI.ileal_enterocyte_absorptive.villus_tip	0.29	Nonsignificant	1.00	0.00	Other	4	3
334	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.29	Nonsignificant	0.24	1.44	Other	11	22
335	T.CD4_transitional.baseline	0.28	Nonsignificant	4.71e-04	1.49	Other	59	97
336	MONO.CD14.APC_like	0.28	Nonsignificant	1.00	0.77	Other	1,686	2,493
337	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.28	Nonsignificant	7.32e-03	1.41	Other	322	317
338	EPI.ileal_enterocyte_crypt.villus_transition	0.28	Nonsignificant	—	1.37	Other	7	10
339	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	0.26	Nonsignificant	—	1.52	Other	0	0
340	T.CD4_Tcm.baseline	0.26	Nonsignificant	1.00	0.51	Other	61	31
341	EPI.lung_multiciliated.stress	0.26	Nonsignificant	—	0.42	Other	67	165
342	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.25	Nonsignificant	—	0.92	Other	0	0
343	EPI.tracheal_submucosal_gland.acinar_serous	0.25	Nonsignificant	—	0.00	Other	0	0
344	EPI.salivary_intercalated_defense.inflammatory	0.25	Nonsignificant	0.68	0.83	Other	152	360
345	FIB.suburothelial.urothelial_interface	0.25	Nonsignificant	0.14	1.85	Other	9	8
346	EPI.tracheal_suprabasal.secretory_immune	0.24	Nonsignificant	—	0.00	Other	0	0
347	PERI.baseline	0.24	Nonsignificant	0.03	1.19	Other	39	66
348	DC.cDC2.migratory	0.24	Nonsignificant	0.99	1.03	Other	185	39
349	THYMO.DN_preTCR	0.24	Nonsignificant	0.21	1.16	Other	41	71
350	EPI.lung_multiciliated.baseline	0.24	Nonsignificant	—	0.00	Other	0	7
351	EPI.salivary_duct_ion_transport.baseline	0.24	Nonsignificant	—	—	Other	0	0
352	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.23	Nonsignificant	0.75	1.17	Other	2	9
353	T.CD4_Tem.transitional_CM	0.23	Nonsignificant	1.00	0.20	Other	31	20
354	EPI.tracheal_submucosal_gland.ductal_luminal	0.22	Nonsignificant	—	0.00	Other	0	0
355	FIB.suburothelial.homeostasis_matrix	0.22	Nonsignificant	0.52	0.92	Other	258	921
356	FIB.lung_alveolar.stress_interacting	0.21	Nonsignificant	—	0.97	Other	0	0
357	FIB.suburothelial.contractile_myofibroblast	0.21	Nonsignificant	—	0.00	Other	9	0
358	FIB.suburothelial.inflammatory_prostanoid	0.21	Nonsignificant	—	0.00	Other	0	0
359	SMC.metabolic	0.21	Nonsignificant	0.89	0.95	Other	14	40
360	PC.IgG_systemic.secretory	0.20	Nonsignificant	0.97	0.94	Other	0	0
361	EPI.pancreatic_acinar.inflammatory_regenerative	0.20	Nonsignificant	0.75	1.03	Other	25	113
362	MONO.CD16.baseline	0.20	Nonsignificant	0.99	0.56	Other	50	1
363	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.19	Nonsignificant	—	0.00	Other	0	0
364	EPI.renal_distal_tubule.immune_modulatory	0.19	Nonsignificant	—	6.94e-17	Other	0	0
365	T.CD4_Trm.metal_stress	0.19	Nonsignificant	0.42	1.33	Other	34	58
366	MONO.CD16.hepatic_mac_like	0.19	Nonsignificant	0.05	1.45	Other	803	117
367	PC.IgA_muocsal.activated	0.19	Nonsignificant	0.74	1.05	Other	17	8
368	GRANU.MAST.resting_granule	0.18	Nonsignificant	—	0.63	Other	0	0
369	MEL.stress_glucocorticoid	0.18	Nonsignificant	0.82	0.92	Other	11	34
370	T.CD4_Trm.baseline	0.18	Nonsignificant	0.81	1.09	Other	31	21
371	ASTRO.A1_reactive	0.17	Nonsignificant	0.16	1.23	Other	433	394
372	EPI.skin_sebaceous_duct_luminal.detox_repair	0.17	Nonsignificant	0.85	0.57	Other	137	94
373	MAC.resident_repair.lipid_phagocytic	0.17	Nonsignificant	0.58	1.18	Other	228	604
374	PC.IgA_muocsal.migratory	0.17	Nonsignificant	0.74	0.99	Other	4	1
375	EPI.skin_sweat_duct_keratinocyte.repair	0.17	Nonsignificant	—	0.57	Other	0	0
376	EPI.renal_principal_cell.canonical_vasopressin	0.16	Nonsignificant	0.58	1.29	Other	2	0
377	B.germinal_center.DZ_M_phase	0.16	Nonsignificant	—	1.47	Other	0	0
378	EPI.renal_distal_tubule.stress	0.16	Nonsignificant	—	0.00	Other	0	0
379	GRNLSA.lipid_hypoxia	0.16	Nonsignificant	0.48	1.11	Other	28	0
380	PC.IgA_muocsal.baseline	0.16	Nonsignificant	0.74	1.00	Other	3	5
381	SMC.contractile	0.16	Nonsignificant	0.95	0.71	Other	80	588
382	FIB.adventitial.complement_angiocrine	0.16	Nonsignificant	1.00	0.82	Other	153	684
383	EPI.pancreatic_ductal_bicarbonate.stress	0.16	Nonsignificant	—	0.00	Other	12	33
384	T.CD4_Treg.tissue_effector	0.15	Nonsignificant	0.70	1.10	Other	16	13
385	T.CD4_naive.Treg_like	0.15	Nonsignificant	1.00	0.23	Other	121	72
386	THYMO.SP_CD8_naive_stress	0.14	Nonsignificant	0.21	1.21	Other	1	1
387	EPI.gastric_foveolar.baseline	0.14	Nonsignificant	—	0.00	Other	0	0
388	FIB.adventitial.inflammatory_activated	0.13	Nonsignificant	1.00	0.91	Other	100	473
389	EPI.lung_multiciliated.mature_motile_cilia	0.13	Nonsignificant	—	0.00	Other	0	0
390	T.CD4_transitional.tissue_enagement	0.13	Nonsignificant	0.95	1.12	Other	5	11
391	GRANU.MAST.activated_repair	0.12	Nonsignificant	—	0.08	Other	0	1
392	FIB.lung_alveolar.mito_secretory	0.12	Nonsignificant	—	0.00	Other	0	0
393	MAC.resident_repair.stress_iron	0.12	Nonsignificant	0.58	1.15	Other	48	97
394	EPI.renal_principal_cell.inflammatory	0.11	Nonsignificant	0.66	1.14	Other	74	157
395	THYMO.proliferative_G2M	0.11	Nonsignificant	—	0.76	Other	164	413
396	ASTRO.stress_acute	0.11	Nonsignificant	1.00	1.08	Other	60	56
397	T.CD4_transitional.primed_cytotoxic	0.10	Nonsignificant	1.00	0.73	Other	28	30
398	MAC.proliferating.stress	0.10	Nonsignificant	—	0.00	Other	87	136
399	PERI.angiocrine	0.10	Nonsignificant	1.00	0.89	Other	93	102
400	EPI.renal_thick_ascending_limb.barrier_repair	0.10	Nonsignificant	1.00	0.84	Other	141	284
401	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.10	Nonsignificant	—	0.98	Other	29	88
402	T.CD4_Tfh.suppression_exhaustion	0.10	Nonsignificant	0.72	1.15	Other	0	2
403	EPI.renal_immature_ureteric_bud.defense_secretory	0.10	Nonsignificant	0.12	1.26	Other	45	76
404	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.09	Nonsignificant	—	0.09	Other	0	0
405	THYMO.CD8aa_IELp	0.09	Nonsignificant	—	0.64	Other	1	7
406	EPI.renal_thick_ascending_limb.salt_sensing	0.09	Nonsignificant	1.00	0.90	Other	73	103
407	HEP.pericentral_lipoprotein.ApoB_coagulation	0.09	Nonsignificant	—	0.67	Other	0	0
408	EPI.renal_principal_cell.activated_acute	0.09	Nonsignificant	0.66	1.04	Other	29	59
409	T.CD4_Tfh.canonical_GC_helper	0.09	Nonsignificant	0.72	1.04	Other	1	2
410	MEL.secretory_quiescent	0.09	Nonsignificant	0.82	0.87	Other	19	13
411	MAC.resident_iron.heme_catabolism	0.09	Nonsignificant	0.15	1.34	Other	30	51
412	T.CD4_Trm.cytotoxic_effector	0.09	Nonsignificant	0.83	0.91	Other	118	77
413	EPI.ileal_goblet.immature	0.08	Nonsignificant	—	0.27	Other	0	0
414	MAC.LAM.anti_inflammatory	0.08	Nonsignificant	0.55	1.13	Other	86	132
415	MAC.resident_iron.stress_tolerogenic	0.08	Nonsignificant	—	1.07	Other	0	0
416	ASTRO.neuromodulatory	0.08	Nonsignificant	1.00	0.98	Other	34	172
417	HEP.pericentral_lipoprotein.UPR_redox	0.08	Nonsignificant	—	0.00	Other	0	0
418	T.CD4_Trm.central_like	0.08	Nonsignificant	0.83	0.86	Other	38	31
419	EPI.ileal_enterocyte_crypt.bile_transport	0.08	Nonsignificant	0.90	0.74	Other	2	0
420	T.CD4_Trm.helper_like	0.07	Nonsignificant	0.81	1.06	Other	84	147
421	B.memory.activated	0.07	Nonsignificant	0.14	1.24	Other	105	29
422	DC.cDC2.proliferative	0.07	Nonsignificant	—	0.30	Other	39	71
423	FIB.adventitial.mechano_chemo_sensing	0.07	Nonsignificant	1.00	0.67	Other	135	524
424	FIB.adventitial.mito_secretory	0.07	Nonsignificant	0.59	1.27	Other	21	7
425	T.CD4_Tcm.APC_mimicry	0.07	Nonsignificant	1.00	0.08	Other	54	43
426	B.age_associated.activated	0.07	Nonsignificant	—	0.35	Other	18	22
427	FIB.adventitial.baseline	0.07	Nonsignificant	1.00	0.41	Other	157	278
428	T.CD4_Treg.APC_interactive	0.07	Nonsignificant	0.70	1.02	Other	118	28
429	PC.IgA_muocsal.plasmablast	0.07	Nonsignificant	0.78	0.83	Other	5	4
430	T.CD4_Tfh.effector_migratory	0.07	Nonsignificant	0.72	1.00	Other	122	57
431	EPI.ileal_enterocyte_crypt.secretory_precursor	0.07	Nonsignificant	—	0.05	Other	0	0
432	EPI.renal_thick_ascending_limb.cation_flux	0.06	Nonsignificant	1.00	0.91	Other	57	95
433	T.CD4_naive.activated_stress	0.06	Nonsignificant	1.00	6.36e-03	Other	339	429
434	EPI.ileal_enterocyte_crypt.proliferative_S	0.06	Nonsignificant	0.90	0.52	Other	4	2
435	GRANU.MAST.activated_acute	0.06	Nonsignificant	—	0.00	Other	0	0
436	EPI.ectocervical_granular.secretory_apocrine	0.06	Nonsignificant	—	1.15	Other	0	0
437	EPI.esophageal_basal.activated_progenitor	0.06	Nonsignificant	0.04	1.47	Other	1	0
438	DC.cDC2.adhesion_signaling	0.05	Nonsignificant	0.99	0.81	Other	35	9
439	T.CD4_transitional.APC_interacting	0.05	Nonsignificant	1.00	0.43	Other	10	14
440	EPI.renal_thick_ascending_limb.remodeling	0.05	Nonsignificant	1.00	0.54	Other	152	92
441	EPI.ectocervical_granular.proliferative_basal	0.05	Nonsignificant	—	0.32	Other	0	0
442	THYMO.DP_early_stress	0.05	Nonsignificant	—	0.74	Other	0	0
443	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.05	Nonsignificant	—	0.31	Other	2	0
444	EPI.skin_sweat_duct_keratinocyte.barrier	0.05	Nonsignificant	—	0.00	Other	0	0
445	MAC.proliferating.DNA_replication	0.05	Nonsignificant	0.72	0.91	Other	3	6
446	GRNLSA.stress_metabolic	0.05	Nonsignificant	—	0.56	Other	1	2
447	MAC.microglia_like.inflammatory_chemokine	0.05	Nonsignificant	—	0.00	Other	20	32
448	EPI.pancreatic_acinar.adhesion_remodeling	0.05	Nonsignificant	0.41	1.16	Other	210	784
449	EPI.ileal_enterocyte_crypt.baseline	0.05	Nonsignificant	0.90	0.68	Other	11	6
450	THYMO.SP_CD8_transitional	0.05	Nonsignificant	1.00	0.98	Other	32	75
451	MAC.MDM.inflammatory_phagocytic	0.05	Nonsignificant	0.65	1.08	Other	199	52
452	T.CD4_transitional.primed_helper_effector	0.05	Nonsignificant	1.00	0.30	Other	19	43
453	B.age_associated.naive_transitional	0.05	Nonsignificant	—	0.00	Other	0	0
454	T.CD4_Trm.stress_adaptive	0.04	Nonsignificant	0.83	1.02	Other	8	22
455	MAC.microglia_like.phagocytic_redox	0.04	Nonsignificant	—	0.00	Other	0	0
456	FIB.hepatic_stellate_cell.inflammatory	0.04	Nonsignificant	—	0.32	Other	0	0
457	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.04	Nonsignificant	—	0.00	Other	43	26
458	DC.cDC2.antiviral	0.04	Nonsignificant	0.99	0.69	Other	100	37
459	FIB.hepatic_stellate_cell.contractile	0.04	Nonsignificant	—	0.00	Other	0	0
460	MEL.mature_oxidative_traffic	0.04	Nonsignificant	0.82	1.05	Other	247	285
461	EPI.renal_principal_cell.intercalated_like	0.04	Nonsignificant	0.58	1.27	Other	63	66
462	EPI.alveolar_type_1.baseline	0.04	Nonsignificant	1.00	0.00	Other	8	0
463	MAC.resident_iron.redox_metabolic	0.04	Nonsignificant	0.82	1.02	Other	4	4
464	EPI.lung_club_secretory.inflammatory	0.04	Nonsignificant	—	0.37	Other	0	0
465	FIB.hepatic_stellate_cell.fibrogenic	0.04	Nonsignificant	—	0.00	Other	0	0
466	B.age_associated.migratory	0.04	Nonsignificant	0.85	0.51	Other	2	2
467	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.04	Nonsignificant	—	0.00	Other	135	290
468	MAC.resident_repair.chemokine_angiocrine	0.03	Nonsignificant	0.67	1.01	Other	87	138
469	ADIPO.thermogenic	0.03	Nonsignificant	—	1.09	Other	0	0
470	EPI.salivary_intercalated_defense.basal_EMT	0.03	Nonsignificant	—	0.00	Other	0	0
471	T.CD4_Th2.tissue_adapted	0.03	Nonsignificant	—	0.00	Other	0	0
472	EPI.pancreatic_ductal_bicarbonate.baseline	0.03	Nonsignificant	0.99	1.13	Other	11	42
473	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.03	Nonsignificant	—	0.42	Other	0	0
474	DC.mig.baseline	0.03	Nonsignificant	—	0.00	Other	1	0
475	HEP.periportal_metabolic.stress_chaperone	0.03	Nonsignificant	—	1.54	Other	66	128
476	MAC.resident_repair.ECM_stromal_crosstalk	0.03	Nonsignificant	0.09	1.15	Other	95	158
477	T.CD4_Tfh.precursor_migratory	0.03	Nonsignificant	0.96	0.69	Other	72	27
478	DC.cDC2.pro_inflammatory	0.03	Nonsignificant	0.99	0.67	Other	3	5
479	EPI.thymic_medullary.canonical_alarmin	0.03	Nonsignificant	0.77	1.23	Other	8	17
480	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.03	Nonsignificant	—	0.00	Other	0	0
481	SCHWN.axon_contact_cardiac	0.03	Nonsignificant	1.00	0.00	Other	18	63
482	EPI.salivary_serous_acinar.secretory_active	0.03	Nonsignificant	0.07	1.18	Other	242	69
483	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.02	Nonsignificant	—	1.59	Other	0	0
484	T.CD4_Trm.activated	0.02	Nonsignificant	0.83	0.78	Other	32	26
485	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.02	Nonsignificant	0.99	0.96	Other	14	32
486	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.02	Nonsignificant	0.99	1.06	Other	219	533
487	EPI.pancreatic_islet.delta	0.02	Nonsignificant	—	0.67	Other	0	0
488	PC.IgG_systemic.metabolic	0.02	Nonsignificant	1.00	0.00	Other	46	63
489	MAC.LAM.inflammatory_APC	0.02	Nonsignificant	0.97	0.94	Other	872	165
490	EPI.skin_hair_follicle_companion.activated_migratory	0.02	Nonsignificant	—	0.97	Other	0	0
491	ASTRO.A2_reactive	0.02	Nonsignificant	1.00	0.85	Other	10	37
492	NEU.EXC_IT.adhesion	0.02	Nonsignificant	1.00	0.14	Other	252	108
493	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.02	Nonsignificant	—	0.00	Other	0	0
494	MAC.LAM.lipid_opsonization	0.02	Nonsignificant	0.55	1.14	Other	45	14
495	ASTRO.synaptic_interaction	0.02	Nonsignificant	1.00	0.73	Other	76	334
496	EPI.ectocervical_granular.inflammatory	0.02	Nonsignificant	—	0.00	Other	0	0
497	EPI.thymic_medullary.hormone_xeno_barrier	0.02	Nonsignificant	—	0.57	Other	0	8
498	B.germinal_center.LZ_memory_precursor	0.02	Nonsignificant	—	0.37	Other	0	0
499	MG.expanding	0.02	Nonsignificant	0.59	1.12	Other	2	1
500	MAC.kupffer.stress	0.02	Nonsignificant	0.52	1.04	Other	9	3
501	MAC.resident_repair.antigen_presenting	0.02	Nonsignificant	0.87	0.90	Other	244	113
502	MG.phagocytic_APC	0.02	Nonsignificant	0.17	1.31	Other	25	8
503	EPI.pancreatic_acinar.baseline	0.02	Nonsignificant	1.00	0.75	Other	274	163
504	B.germinal_center.LZ_selection	0.02	Nonsignificant	—	0.00	Other	0	0
505	B.germinal_center.DZ_S_phase	0.02	Nonsignificant	—	0.00	Other	0	0
506	MAC.kupffer.tolerogenic	0.02	Nonsignificant	—	0.67	Other	45	49
507	ASTRO.immature_lipid	0.01	Nonsignificant	1.00	0.87	Other	23	113
508	B.memory.migratory	0.01	Nonsignificant	0.96	0.97	Other	123	208
509	B.naive.metabolic	0.01	Nonsignificant	0.88	1.07	Other	50	79
510	ADIPO.hypoxia_remodelling	0.01	Nonsignificant	—	0.32	Other	29	105
511	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.01	Nonsignificant	—	0.00	Other	0	0
512	EPI.skin_sebaceous_duct_luminal.immune_interface	0.01	Nonsignificant	—	0.00	Other	0	0
513	T.CD4_Treg.central_naive_like	0.01	Nonsignificant	0.98	0.77	Other	333	45
514	CHOND.angiogenic	0.01	Nonsignificant	—	1.46	Other	0	0
515	B.naive.baseline	0.01	Nonsignificant	0.88	1.13	Other	10	13
516	MAC.resident_iron.APC_iron_sensing	0.01	Nonsignificant	0.82	0.85	Other	211	114
517	EPI.hepatic_ductular_cholangiocyte.stress	0.01	Nonsignificant	—	1.01	Other	0	0
518	EPI.skin_keratinocyte_basal.transit_amplifying	0.01	Nonsignificant	—	0.97	Other	0	0
519	MAC.kupffer.inflammatory	0.01	Nonsignificant	—	0.00	Other	7	4
520	B.naive.purinergic	0.01	Nonsignificant	6.95e-04	1.20	Other	384	820
521	CHOND.articular_collagen	0.01	Nonsignificant	0.32	1.18	Other	551	266
522	EPI.skin_keratinocyte_proliferating.anchor_remodel	9.63e-03	Nonsignificant	—	0.00	Other	0	0
523	EPI.colonocyte.distal_absorptive	8.81e-03	Nonsignificant	—	1.24	Other	0	0
524	B.germinal_center.LZ_survival	8.62e-03	Nonsignificant	—	0.00	Other	0	0
525	ASTRO.hypoxia_angiogenic	8.52e-03	Nonsignificant	1.00	0.92	Other	5	18
526	HEP.periportal_metabolic.apolipoprotein_secretory	8.50e-03	Nonsignificant	0.41	1.28	Other	43	110
527	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	8.50e-03	Nonsignificant	—	0.98	Other	0	0
528	EPI.renal_principal_cell.injury_repair	8.27e-03	Nonsignificant	0.99	0.25	Other	26	9
529	MAC.resident_cardiac.inflammatory_reparative	8.23e-03	Nonsignificant	0.13	1.35	Other	31	96
530	GRNLSA.secretory_remodeling	8.12e-03	Nonsignificant	0.99	0.72	Other	90	25
531	PERI.cardiac_skeletal	7.54e-03	Nonsignificant	1.00	0.02	Other	313	630
532	EPI.skin_interfollicular_spinous.inflammatory	7.47e-03	Nonsignificant	—	1.83	Other	0	0
533	B.memory.preactivated	7.40e-03	Nonsignificant	0.96	0.89	Other	173	174
534	B.memory.baseline	7.39e-03	Nonsignificant	0.99	0.81	Other	472	99
535	EPI.renal_distal_tubule.ion_transport	7.35e-03	Nonsignificant	—	0.00	Other	0	0
536	EPI.esophageal_suprabasal.differentiating_keratin	7.14e-03	Nonsignificant	0.02	1.39	Other	131	61
537	EPI.pancreatic_islet.alpha	7.04e-03	Nonsignificant	—	0.00	Other	152	330
538	EPI.colonocyte.crypt_progenitor	7.04e-03	Nonsignificant	0.33	1.18	Other	115	265
539	EPI.skin_keratinocyte_basal.spinous_transition	7.00e-03	Nonsignificant	—	0.00	Other	0	0
540	GRNLSA.chemokine_mechanosensory	6.81e-03	Nonsignificant	0.99	0.65	Other	1	0
541	MG.baseline	6.77e-03	Nonsignificant	0.98	0.56	Other	16	5
542	DC.cDC2.tolerogenic_regulatory	6.64e-03	Nonsignificant	0.99	0.75	Other	44	4
543	THYMO.SP_CD4_naive	6.50e-03	Nonsignificant	1.00	0.72	Other	65	75
544	CHOND.remodeling	6.03e-03	Nonsignificant	—	0.68	Other	5	0
545	EPI.bile_duct_cholangiocyte.secretory_mucin	5.94e-03	Nonsignificant	—	0.00	Other	7	12
546	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	5.75e-03	Nonsignificant	—	0.10	Other	0	0
547	EPI.lung_club_secretory.canonical_surfactant	5.74e-03	Nonsignificant	—	0.00	Other	74	104
548	EPI.pancreatic_ductal_bicarbonate.activated	5.50e-03	Nonsignificant	1.00	0.59	Other	10	7
549	MAC.MDM.complement_resolving	5.49e-03	Nonsignificant	0.93	0.80	Other	440	860
550	EPI.skin_hair_follicle_companion.gap_junction_contractile	5.42e-03	Nonsignificant	—	0.00	Other	0	0
551	B.naive.antigen_presenting_ready	5.39e-03	Nonsignificant	0.94	0.98	Other	48	73
552	EPI.pancreatic_ductal_perivascular.protective_antioxidant	5.32e-03	Nonsignificant	—	0.00	Other	11	69
553	EPI.ileal_goblet.inflammatory_mucin	5.30e-03	Nonsignificant	0.69	1.05	Other	6	9
554	MAC.resident_cardiac.phagocytic_homeostasis	5.25e-03	Nonsignificant	0.83	0.87	Other	564	1,221
555	EPI.hepatic_ductular_cholangiocyte.polarity	5.19e-03	Nonsignificant	—	0.32	Other	0	0
556	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	5.11e-03	Nonsignificant	—	0.00	Other	0	0
557	MAC.resident_cardiac.antigen_presenting	5.07e-03	Nonsignificant	0.83	0.93	Other	52	27
558	EPI.pancreatic_ductal_progenitor.ADM_like	4.88e-03	Nonsignificant	—	1.79	Other	0	0
559	MAC.LAM.antimicrobial	4.81e-03	Nonsignificant	0.55	1.11	Other	389	93
560	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	4.60e-03	Nonsignificant	—	0.03	Other	0	0
561	SKM.type_2_fast.oxidative_IIa	4.49e-03	Nonsignificant	9.62e-04	1.61	Other	946	56
562	EPI.thymic_medullary.stress_APC	4.45e-03	Nonsignificant	0.91	0.40	Other	2	4
563	B.naive.activated	4.25e-03	Nonsignificant	0.94	0.94	Other	77	127
564	EPI.ileal_goblet.baseline	4.23e-03	Nonsignificant	0.69	0.69	Other	16	2
565	OLG.regulatory_activated	4.21e-03	Nonsignificant	0.53	1.27	Other	196	614
566	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	4.20e-03	Nonsignificant	—	0.00	Other	6	9
567	EPI.salivary_serous_acinar.quiescent	3.83e-03	Nonsignificant	0.90	0.72	Other	178	493
568	EPI.salivary_serous_acinar.seromucous_like	3.73e-03	Nonsignificant	—	0.39	Other	0	0
569	B.naive.restrained	3.67e-03	Nonsignificant	0.95	0.86	Other	183	353
570	EPI.renal_immature_ureteric_bud.osmoprotective	3.59e-03	Nonsignificant	1.00	0.16	Other	126	44
571	B.naive.receptor_recycle	3.57e-03	Nonsignificant	0.94	0.90	Other	51	0
572	EPI.skin_follicular_keratinizing.root_infundibulum	3.49e-03	Nonsignificant	—	0.46	Other	0	0
573	EPI.skin_follicular_keratinizing.transit_amplifying	3.41e-03	Nonsignificant	—	0.15	Other	21	49
574	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	3.25e-03	Nonsignificant	—	0.55	Other	0	0
575	B.naive.proteostasis	3.23e-03	Nonsignificant	0.94	1.00	Other	49	69
576	THYMO.DP_early	3.09e-03	Nonsignificant	1.00	0.66	Other	326	313
577	OLG.stress	2.96e-03	Nonsignificant	0.53	1.13	Other	232	8
578	B.memory.pDC_imprint	2.87e-03	Nonsignificant	0.96	1.10	Other	157	103
579	MAC.MDM.APC_dendritic	2.85e-03	Nonsignificant	0.93	0.96	Other	48	15
580	HEP.canalicular_transport.secretory_ERAD_UPR	2.85e-03	Nonsignificant	0.54	1.15	Other	232	28
581	EPI.ileal_goblet.stress_metallothionein	2.78e-03	Nonsignificant	—	0.00	Other	4	11
582	CHOND.pro_inflammatory	2.68e-03	Nonsignificant	1.00	0.81	Other	181	351
583	EPI.pancreatic_ductal_perivascular.baseline	2.57e-03	Nonsignificant	0.67	0.87	Other	1	5
584	EPI.colonocyte.proximal_transport	2.34e-03	Nonsignificant	0.91	0.81	Other	24	12
585	GRNLSA.p53_damage	2.32e-03	Nonsignificant	—	0.00	Other	13	10
586	EPI.pancreatic_acinar.metabolic_onecarbon	2.25e-03	Nonsignificant	1.00	0.59	Other	287	328
587	EPI.colonocyte.ionocyte_BEST4	2.24e-03	Nonsignificant	0.33	1.36	Other	103	188
588	EPI.salivary_myoepithelial.contractile_repair	2.16e-03	Nonsignificant	—	1.04	Other	3	9
589	EPI.skin_hair_follicle_bulge.anagen_growth	2.15e-03	Nonsignificant	—	0.92	Other	0	0
590	DC.pDC.poised_migratory	2.09e-03	Nonsignificant	0.12	1.61	Other	54	95
591	EPI.skin_follicular_keratinizing.upper_infundibulum	2.01e-03	Nonsignificant	—	0.00	Other	8	2
592	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	1.96e-03	Nonsignificant	—	0.00	Other	5	3
593	B.naive.remodeling	1.84e-03	Nonsignificant	0.94	0.90	Other	135	230
594	SKM.type_2_fast.glycolytic_IIx_IIb	1.81e-03	Nonsignificant	1.00	0.10	Other	565	1,482
595	HEP.canalicular_transport.ductular_like_transition	1.80e-03	Nonsignificant	0.54	1.09	Other	400	87
596	OLG.regulatory	1.76e-03	Nonsignificant	0.87	1.05	Other	353	73
597	HEP.acute_phase.inflammatory	1.74e-03	Nonsignificant	0.30	1.21	Other	382	649
598	EPI.skin_interfollicular_spinous.upper_lipid	1.73e-03	Nonsignificant	—	0.80	Other	6	6
599	EPI.skin_interfollicular_spinous.stress_oxidative	1.60e-03	Nonsignificant	—	0.97	Other	0	0
600	CHOND.activated_fibro_like	1.46e-03	Nonsignificant	1.00	0.54	Other	531	188
601	EPI.colonocyte.secretory_boost	1.32e-03	Nonsignificant	0.91	0.76	Other	98	91
602	HEP.canalicular_transport.pericentral_like_hypoxia	1.26e-03	Nonsignificant	0.54	1.11	Other	326	8
603	EPI.esophageal_suprabasal.basal_transitional	1.23e-03	Nonsignificant	0.78	0.72	Other	44	67
604	OLG.myelinating_mature	1.23e-03	Nonsignificant	0.96	0.97	Other	363	94
605	EPI.skin_appendage_keratinocyte.transit_amplifying	1.18e-03	Nonsignificant	—	0.00	Other	109	358
606	MAC.resident_iron.heme_recycling	1.16e-03	Nonsignificant	—	0.00	Other	30	37
607	DC.pDC.baseline	1.14e-03	Nonsignificant	0.78	0.86	Other	88	123
608	HEP.acute_phase.stress_secretory	1.11e-03	Nonsignificant	0.30	1.35	Other	26	3
609	SKM.type_1_slow.glycolytic	1.09e-03	Nonsignificant	0.15	1.11	Other	362	647
610	EPI.pancreatic_ductal_progenitor.baseline	1.06e-03	Nonsignificant	0.74	0.85	Other	179	702
611	EPI.extrahepatic_cholangiocyte.mucin_secretory	1.05e-03	Nonsignificant	—	0.73	Other	0	0
612	HEP.canalicular_transport.injury_stress	1.02e-03	Nonsignificant	0.54	1.06	Other	289	24
613	EPI.thymic_medullary.proliferative_APC	9.93e-04	Nonsignificant	—	0.00	Other	0	0
614	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	9.46e-04	Nonsignificant	—	0.00	Other	0	0
615	EPI.lung_club_secretory.ciliogenesis_primed	8.90e-04	Nonsignificant	—	0.00	Other	0	0
616	EPI.esophageal_basal.junctional_barrier	8.77e-04	Nonsignificant	—	0.00	Other	0	0
617	DC.pDC.immature_metabolic	8.56e-04	Nonsignificant	0.78	0.72	Other	78	124
618	DC.cDC1.baseline	8.54e-04	Nonsignificant	—	1.53	Other	0	0
619	EPI.hepatic_ductular_cholangiocyte.ion_transport	8.33e-04	Nonsignificant	—	0.00	Other	0	0
620	MAC.kupffer.metabolic	8.28e-04	Nonsignificant	—	0.00	Other	25	36
621	EPI.esophageal_suprabasal.proliferative_G2M	7.99e-04	Nonsignificant	—	0.00	Other	0	0
622	OLG.myelinating_stress	7.55e-04	Nonsignificant	0.92	0.98	Other	232	62
623	EPI.colonocyte.junction_remodeling	7.49e-04	Nonsignificant	0.91	0.70	Other	218	305
624	HEP.acute_phase.proliferative	7.33e-04	Nonsignificant	—	0.72	Other	4	6
625	EPI.ectocervical_granular.immune_interact	7.33e-04	Nonsignificant	—	0.00	Other	0	0
626	THYMO.SP_CD8_naive	6.69e-04	Nonsignificant	1.00	0.25	Other	297	177
627	EPI.skin_hair_follicle_bulge.quiescent	6.55e-04	Nonsignificant	1.00	0.00	Other	56	69
628	DC.cDC1.cross_presenting	6.50e-04	Nonsignificant	—	0.69	Other	0	0
629	EPI.alveolar_type_2.baseline_surfactant	5.94e-04	Nonsignificant	0.23	1.12	Other	64	9
630	EPI.colonocyte.goblet_interface	5.93e-04	Nonsignificant	—	0.00	Other	11	21
631	ASTRO.stress_mito	5.92e-04	Nonsignificant	1.00	0.48	Other	47	110
632	EPI.esophageal_suprabasal.proliferative_S	5.57e-04	Nonsignificant	—	0.00	Other	26	41
633	DC.cDC1.proliferative	5.14e-04	Nonsignificant	—	0.16	Other	0	0
634	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	4.77e-04	Nonsignificant	1.00	0.07	Other	449	1,034
635	EPI.skin_keratinocyte_basal.basement_anchoring	4.72e-04	Nonsignificant	—	0.00	Other	0	0
636	GRNLSA.cholesterol_mevalonate	3.98e-04	Nonsignificant	0.99	0.46	Other	9	4
637	EPI.skin_interfollicular_spinous.baseline	3.77e-04	Nonsignificant	0.96	0.83	Other	35	3
638	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	3.54e-04	Nonsignificant	0.83	1.09	Other	7	16
639	EPI.salivary_myoepithelial.baseline	2.97e-04	Nonsignificant	0.88	0.95	Other	42	141
640	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	2.95e-04	Nonsignificant	—	0.00	Other	49	237
641	MAC.LAM.lipid_phagocytosis	2.82e-04	Nonsignificant	0.97	0.66	Other	369	328
642	HEP.acute_phase.complement_antiviral	2.75e-04	Nonsignificant	0.75	1.06	Other	377	751
643	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.65e-04	Nonsignificant	—	0.00	Other	105	368
644	EPI.skin_interfollicular_spinous.transition_basal	2.59e-04	Nonsignificant	0.96	0.65	Other	100	127
645	GRANU.neutrophil.antiviral_endotoxin	2.57e-04	Nonsignificant	—	0.90	Other	0	0
646	EPI.esophageal_suprabasal.proliferative_exit	2.51e-04	Nonsignificant	—	0.00	Other	0	0
647	MAC.kupffer.monocyte_like	2.35e-04	Nonsignificant	—	0.00	Other	0	0
648	MAC.kupffer.fibrogenic	2.34e-04	Nonsignificant	—	0.00	Other	0	0
649	EPI.extrahepatic_cholangiocyte.barrier_interface	2.30e-04	Nonsignificant	—	0.00	Other	0	0
650	OLG.reactive_repair	2.05e-04	Nonsignificant	1.00	0.53	Other	385	385
651	HEP.periportal_metabolic.stress_checkpoint	1.90e-04	Nonsignificant	0.94	1.11	Other	234	786
652	EPI.skin_interfollicular_spinous.early_differentiation	1.90e-04	Nonsignificant	0.96	0.49	Other	89	19
653	DC.cDC1.activated	1.65e-04	Nonsignificant	—	0.00	Other	0	0
654	T.CD4_Treg.Tr1_like	1.55e-04	Nonsignificant	—	0.00	Other	8	8
655	ASTRO.homeostatic	1.44e-04	Nonsignificant	1.00	0.16	Other	200	431
656	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.43e-04	Nonsignificant	1.00	0.03	Other	40	191
657	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.30e-04	Nonsignificant	0.83	0.71	Other	33	34
658	EPI.skin_interfollicular_spinous.stress_UPR	1.26e-04	Nonsignificant	—	0.00	Other	0	0
659	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.14e-04	Nonsignificant	—	0.00	Other	0	0
660	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.13e-04	Nonsignificant	—	0.00	Other	0	0
661	EPI.salivary_myoepithelial.activated	1.10e-04	Nonsignificant	0.88	0.78	Other	85	281
662	OLG.vesicle_trafficking	9.91e-05	Nonsignificant	1.00	0.27	Other	124	10
663	HEP.canalicular_transport.inflammatory	9.17e-05	Nonsignificant	1.00	0.32	Other	1,335	194
664	GRANU.neutrophil.primed_degranulation	7.24e-05	Nonsignificant	—	0.00	Other	0	0
665	EPI.alveolar_type_2.injury_primed	6.19e-05	Nonsignificant	1.00	0.93	Other	434	245
666	EPI.skin_interfollicular_spinous.proliferative	6.02e-05	Nonsignificant	—	0.00	Other	0	0
667	HEP.canalicular_transport.sterol_lipid_biosynthesis	5.08e-05	Nonsignificant	—	0.00	Other	10	20
668	EPI.salivary_myoepithelial.junctional_transport	4.54e-05	Nonsignificant	0.88	0.92	Other	66	121
669	MAC.LAM.perivascular_angiocrine	3.72e-05	Nonsignificant	—	0.00	Other	53	138
670	ADIPO.immature	3.55e-05	Nonsignificant	—	0.00	Other	24	40
671	DC.cDC1.homeostatic_inhibitory	3.03e-05	Nonsignificant	—	0.00	Other	0	0
672	HEP.canalicular_transport.baseline	2.97e-05	Nonsignificant	1.00	0.29	Other	199	477
673	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.25e-05	Nonsignificant	—	0.00	Other	0	0
674	HEP.acute_phase.baseline	2.19e-05	Nonsignificant	1.00	0.46	Other	946	19
675	GRANU.neutrophil.tissue_patrolling	1.59e-05	Nonsignificant	—	0.00	Other	0	0
676	HEP.acute_phase.complement_metabolic	1.56e-05	Nonsignificant	1.00	0.36	Other	1,423	3,464
677	HEP.periportal_metabolic.inflammatory_activated	9.52e-06	Nonsignificant	1.00	0.95	Other	712	1,610
678	EPI.alveolar_type_2.stress_response	7.89e-06	Nonsignificant	1.00	0.72	Other	675	1,562
679	GRNLSA.angiocrine_mechanosensory	4.42e-06	Nonsignificant	—	0.00	Other	0	0
680	HEP.periportal_metabolic.acute_phase_barrier	2.67e-06	Nonsignificant	1.00	0.98	Other	533	138
681	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.47e-06	Nonsignificant	—	0.00	Other	39	82
682	HEP.acute_phase.hypoxia_lipid	8.92e-07	Nonsignificant	—	0.00	Other	0	0
683	HEP.periportal_metabolic.urea_onecarbon_secretory	6.20e-07	Nonsignificant	1.00	0.72	Other	1,332	3,053
684	ADIPO.inflammatory	5.36e-07	Nonsignificant	—	0.00	Other	0	0
685	HEP.periportal_metabolic.xenobiotic_detox	4.61e-07	Nonsignificant	1.00	0.71	Other	1,440	139
686	HEP.periportal_metabolic.canonical_urea_cycle	1.78e-07	Nonsignificant	1.00	0.57	Other	1,464	269
687	SKM.type_1_slow.contractile	6.40e-08	Nonsignificant	1.00	0.84	Other	596	8
688	SKM.type_1_slow.oxidative	2.09e-09	Nonsignificant	1.00	0.49	Other	802	251

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

6 unique genes. Showing 1–6. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
VCAN	02-Medium	0.56	16.16	G1	C2	ASTRO.A1_reactive (L2), DC.cDC2.monocyte_like (L2), EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (L2), EPI.thymic_medullary.canonical_alarmin (L2), MONO.CD14.baseline (L2), MONO.CD16.inflammatory (L2), NEU.EXC_CT.remodeling (L2)	EC.heart_remodeling (Tier: specific) EC.heart_remodeling.angiocrine (Tier: specific) EC.heart_remodeling.remodeling_secretory (Tier: specific)	103 cells — complete matches	11	255
CD82	02-Medium	0.50	7.37	G1	C2	B.age_associated.migratory (L2), B.germinal_center.LZ_memory_precursor (L2), EPI.skin_hair_follicle_companion.gap_junction_contractile (L2), FIB.interstitial.mesenchymal_regulator (L2), MAC.LAM.anti_inflammatory (L2), OPC.proliferative_immune_interact (L2), T.CD4_Th2.precursor (L2)	EC.capillary (Tier: specific) EC.capillary.angiocrine (Tier: specific) EC.capillary.baseline (Tier: specific) EC.capillary.migratory (Tier: relevant) EC.capillary.stress (Tier: relevant)	75 cells — complete matches	4	13
TSPAN18	02-Medium	0.41	4.95	G1	C2	—	EC.arterial (Tier: specific) EC.capillary (Tier: specific) EC.heart_remodeling.remodeling_secretory (Tier: specific) EC.liver_sinusoidal.stress (Tier: relevant)	70 cells — complete matches	2	12
LINC02704	02-Medium	0.40	4.98	G1	C2	—	—	—	0	4
ENSG00000293465	02-Medium	0.38	9.27	G2	C2	—	—	—	10	99
ENSG00000248112	02-Medium	0.30	7.21	G2	C2	—	—	—	7	87

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.