Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90274792 · All tissues

GDNF levels: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: GDNF levels

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte_precursor_cell	30.35	Significant	6.66e-25	1.85	Specific	461	1,454
2	dendritic_cell	8.23	Significant	9.78e-10	1.42	Other	496	724
3	B_cell	8.17	Significant	6.39e-30	1.40	Specific	356	694
4	T_cell	5.61	Significant	3.30e-49	1.41	Other	470	959
5	schwann_cell	4.72	Nominal	1.00	1.04	Other	10	57
6	monocyte	3.92	Nominal	1.00	0.97	Other	2,176	3,871
7	oligodendrocyte	3.91	Nominal	0.49	1.04	Other	385	1,507
8	skeletal_muscle_cell	3.91	Nominal	2.24e-03	1.18	Other	944	2,600
9	natural_killer_cell	3.77	Nominal	7.48e-04	1.11	Other	1,204	2,052
10	pericyte	3.39	Nominal	1.00	0.93	Other	128	517
11	neuron	3.14	Nominal	1.00	0.88	Other	330	1,328
12	plasma_cell	3.11	Nominal	1.00	0.90	Other	17	24
13	microglia	2.21	Nonsignificant	1.00	0.85	Other	61	129
14	innate_lymphoid_cell_2	2.19	Nonsignificant	1.00	0.72	Other	3	8
15	astrocyte	1.74	Nonsignificant	1.00	0.75	Other	256	1,203
16	smooth_muscle_cell	1.64	Nonsignificant	1.00	0.69	Other	27	139
17	granulosa_cell	1.55	Nonsignificant	1.00	0.69	Other	293	670
18	granulocyte	1.26	Nonsignificant	1.00	0.70	Other	5	6
19	macrophage	1.23	Nonsignificant	1.00	0.66	Other	813	1,732
20	thymocyte	0.98	Nonsignificant	1.00	0.67	Other	168	512
21	melanocyte	0.90	Nonsignificant	1.00	0.63	Other	97	309
22	muscle_stem_cell	0.73	Nonsignificant	1.00	0.61	Other	7	27
23	epithelial_cell	0.44	Nonsignificant	1.00	0.51	Other	24	47
24	fibroblast	0.41	Nonsignificant	1.00	0.52	Other	184	826
25	induced_pluripotent_stem_cell	0.36	Nonsignificant	1.00	0.49	Other	0	0
26	haematopoietic_progenitor_cell	0.30	Nonsignificant	1.00	0.49	Other	262	502
27	adipose_stem_and_progenitor_cell	0.26	Nonsignificant	1.00	0.49	Other	327	954
28	adipocyte	0.23	Nonsignificant	1.00	0.69	Other	33	111
29	endothelial_cell	0.11	Nonsignificant	1.00	0.40	Other	373	974
30	mesothelial_cell	0.04	Nonsignificant	1.00	0.36	Other	6	36
31	cardiomyocyte	0.02	Nonsignificant	1.00	0.45	Other	533	2,045
32	platelet	2.77e-03	Nonsignificant	—	0.00	Other	85	104
33	hepatocyte	2.47e-03	Nonsignificant	1.00	0.52	Other	1,515	3,822
34	chondrocyte	7.04e-04	Nonsignificant	1.00	0.23	Other	548	1,069

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OPC.oligodendrocyte_precursor_cell	30.35	Significant	—	—	Specific	413	1,269
2	DC.pDC	27.28	Significant	6.96e-06	1.60	Specific	496	1,028
3	T.MAIT	10.20	Significant	6.01e-29	2.84	Specific	469	855
4	B.memory	9.78	Significant	2.87e-09	2.00	Specific	442	882
5	T.CD4_cytotoxic	8.77	Significant	1.36e-06	2.05	Specific	855	1,493
6	T.gamma_delta	7.53	Significant	1.12e-08	2.06	Specific	588	1,078
7	T.CD4_Th17	7.38	Significant	5.07e-03	1.62	Specific	421	794
8	B.naive	7.10	Significant	1.00	0.51	Specific	307	595
9	T.CD4_Tem	6.82	Significant	2.25e-03	1.52	Specific	365	697
10	T.CD8_Tcm	6.62	Significant	2.25e-03	1.57	Specific	460	926
11	T.CD4_naive	6.46	Significant	2.87e-16	1.70	Specific	399	866
12	T.CD4_Tcm	6.18	Significant	2.25e-03	1.34	Specific	494	988
13	EPI.colonic_enteroendocrine	6.15	Significant	—	1.63	Other	1	1
14	SKM.type_2_fast	5.94	Significant	1.87e-36	2.72	Specific	972	2,639
15	NEU.EXC_CT	5.75	Significant	5.56e-04	1.95	Specific	362	384
16	T.CD8_transitional	5.64	Significant	0.74	1.02	Other	497	932
17	T.CD8_Tem	5.30	Nominal	0.74	1.01	Other	1,083	1,857
18	B.germinal_center	4.97	Nominal	1.00	0.34	Other	233	655
19	DC.cDC2	4.88	Nominal	1.00	0.51	Other	1,189	1,793
20	MAC.microglia_like	4.88	Nominal	9.03e-04	1.87	Other	124	179
21	B.age_associated	4.77	Nominal	1.00	0.30	Other	207	350
22	SCHWN.schwann_cell	4.72	Nominal	—	—	Other	7	33
23	PC.IgG_systemic	4.41	Nominal	0.49	1.18	Other	41	60
24	NEU.INH_PVALB	4.19	Nominal	0.15	1.42	Other	193	183
25	T.CD4_Trm	4.00	Nominal	1.00	0.65	Other	176	363
26	MONO.CD14	3.94	Nominal	0.70	1.00	Other	2,294	4,139
27	OLG.oligodendrocyte	3.91	Nominal	—	—	Other	384	1,397
28	MONO.CD16	3.81	Nominal	0.70	0.96	Other	1,304	1,835
29	NK.natural_killer_cell	3.77	Nominal	—	—	Other	1,204	2,045
30	T.CD8_naive	3.71	Nominal	1.00	0.35	Other	317	708
31	EPI.bile_duct_cholangiocyte	3.48	Nominal	0.93	1.20	Other	37	60
32	PERI.pericyte	3.39	Nominal	—	—	Other	117	0
33	NEU.EXC_SYT2	3.38	Nominal	—	0.11	Other	40	77
34	EPI.skin_interfollicular_spinous	3.30	Nominal	0.01	1.26	Other	260	563
35	T.CD8_Trm	3.25	Nominal	1.00	0.13	Other	211	346
36	NEU.EXC_IT	3.18	Nominal	0.64	1.06	Other	411	192
37	T.CD4_transitional	3.13	Nominal	1.00	0.06	Other	48	110
38	PC.IgA_muocsal	2.94	Nonsignificant	0.89	0.70	Other	18	31
39	FIB.skin_papillary	2.90	Nonsignificant	—	2.42	Other	0	0
40	EPI.ileal_enterocyte_absorptive	2.81	Nonsignificant	2.27e-03	1.31	Other	118	338
41	EPI.ileal_bile_transport	2.63	Nonsignificant	0.07	1.28	Other	61	93
42	FIB.skin_sheath	2.48	Nonsignificant	0.01	1.54	Other	49	118
43	FIB.skin_tenogenic	2.48	Nonsignificant	—	2.13	Other	108	227
44	MG.microglia	2.21	Nonsignificant	—	—	Other	49	0
45	MAC.resident_iron	2.20	Nonsignificant	0.03	1.43	Other	16	21
46	ILC2.innate_lymphoid_cell_2	2.19	Nonsignificant	—	—	Other	2	0
47	T.CD4_Th2	2.16	Nonsignificant	—	0.00	Other	1	2
48	FIB.skin_neurosecretory	2.13	Nonsignificant	—	1.91	Other	0	0
49	NEU.INH_VIP	1.79	Nonsignificant	1.00	0.19	Other	241	366
50	T.CD4_Tfh	1.76	Nonsignificant	1.00	0.03	Other	47	45
51	ASTRO.astrocyte	1.74	Nonsignificant	—	—	Other	228	1,111
52	SMC.smooth_muscle_cell	1.64	Nonsignificant	—	—	Other	20	101
53	EC.lymphatic	1.59	Nonsignificant	0.01	1.16	Other	630	998
54	GRNLSA.granulosa_cell	1.55	Nonsignificant	—	—	Other	257	0
55	MAC.LAM	1.45	Nonsignificant	9.69e-05	1.48	Other	914	2,064
56	FIB.suburothelial	1.35	Nonsignificant	7.62e-03	1.46	Other	122	432
57	GRANU.MAST	1.27	Nonsignificant	0.41	1.08	Other	5	6
58	GRANU.neutrophil	1.22	Nonsignificant	0.41	1.40	Other	1,235	2,649
59	SKM.type_1_slow	1.17	Nonsignificant	1.00	0.00	Other	923	2,478
60	T.CD4_Treg	1.09	Nonsignificant	1.00	4.06e-03	Other	244	511
61	MAC.MDM	1.06	Nonsignificant	1.00	0.97	Other	623	986
62	EPI.ileal_enterocyte_crypt	1.03	Nonsignificant	1.00	1.02	Other	67	113
63	THYMO.thymocyte	0.98	Nonsignificant	—	—	Other	163	495
64	DC.cDC1	0.97	Nonsignificant	1.00	0.14	Other	55	112
65	MAC.alveolar	0.97	Nonsignificant	1.00	1.03	Other	1,432	3,122
66	FIB.reticular	0.97	Nonsignificant	0.24	1.18	Other	19	87
67	MAC.resident_cardiac	0.94	Nonsignificant	1.00	0.71	Other	485	1,074
68	MAC.resident_repair	0.90	Nonsignificant	1.00	0.69	Other	796	1,426
69	MEL.melanocyte	0.90	Nonsignificant	—	—	Other	79	242
70	EPI.lung_multiciliated	0.89	Nonsignificant	0.93	1.16	Other	16	49
71	EPI.skin_sweat_duct_keratinocyte	0.88	Nonsignificant	1.00	1.09	Other	146	301
72	EPI.alveolar_type_2	0.87	Nonsignificant	0.93	1.09	Other	813	1,853
73	FIB.hepatic_stellate_cell	0.84	Nonsignificant	—	0.98	Other	64	252
74	EPI.renal_distal_tubule	0.84	Nonsignificant	1.00	1.06	Other	133	361
75	DC.mig	0.83	Nonsignificant	—	0.00	Other	89	156
76	MUSC.muscle_stem_cell	0.73	Nonsignificant	—	—	Other	4	18
77	EPI.gastric_foveolar	0.67	Nonsignificant	—	0.98	Other	0	0
78	FIB.neurolectin_mucosa	0.65	Nonsignificant	0.24	1.17	Other	133	394
79	EPI.skin_keratinocyte_proliferating	0.64	Nonsignificant	1.00	1.07	Other	47	76
80	EPI.skin_hair_follicle_bulge	0.64	Nonsignificant	1.00	0.93	Other	51	178
81	FIB.barrier_purinergic	0.63	Nonsignificant	—	0.71	Other	1	3
82	NEU.INH_LAMP5	0.62	Nonsignificant	1.00	0.03	Other	263	532
83	EPI.renal_proximal_tubule	0.61	Nonsignificant	1.00	1.03	Other	525	806
84	HEP.pericentral_lipoprotein	0.58	Nonsignificant	—	2.90	Other	0	0
85	EPI.colonocyte	0.54	Nonsignificant	1.00	0.99	Other	294	815
86	FIB.interstitial	0.53	Nonsignificant	0.04	1.14	Other	288	940
87	FIB.barrier_secretory	0.49	Nonsignificant	0.45	1.14	Other	81	228
88	FIB.perivascular_interface	0.49	Nonsignificant	0.70	0.99	Other	0	0
89	EPI.lung_club_secretory	0.47	Nonsignificant	1.00	0.94	Other	5	14
90	MAC.proliferating	0.46	Nonsignificant	1.00	0.24	Other	87	253
91	EPI.tracheal_submucosal_gland	0.42	Nonsignificant	—	0.62	Other	0	0
92	FIB.transitioning	0.42	Nonsignificant	0.86	0.88	Other	172	497
93	EPI.ectocervical_granular	0.40	Nonsignificant	—	0.70	Other	11	23
94	IPSC.induced_pluripotent_stem_cell	0.36	Nonsignificant	—	—	Other	0	0
95	NEU.EXC_NTNG1	0.35	Nonsignificant	—	0.00	Other	0	0
96	EPI.skin_follicular_keratinizing	0.32	Nonsignificant	1.00	0.86	Other	30	81
97	HPC.haematopoietic_progenitor_cell	0.30	Nonsignificant	—	—	Other	211	370
98	MAC.kupffer	0.27	Nonsignificant	1.00	0.11	Other	189	530
99	ASPC.adipose_stem_and_progenitor_cell	0.26	Nonsignificant	—	—	Other	324	930
100	EPI.pancreatic_islet	0.26	Nonsignificant	1.00	0.87	Other	52	132
101	FIB.lung_alveolar	0.25	Nonsignificant	—	0.14	Other	6	15
102	EPI.skin_keratinocyte_basal	0.24	Nonsignificant	—	0.53	Other	13	26
103	ADIPO.adipocyte	0.23	Nonsignificant	—	—	Other	20	62
104	EPI.esophageal_suprabasal	0.22	Nonsignificant	1.00	0.85	Other	158	404
105	EPI.ileal_goblet	0.20	Nonsignificant	1.00	0.82	Other	181	432
106	EPI.salivary_mucous_acinar	0.19	Nonsignificant	1.00	0.86	Other	639	1,189
107	EPI.skin_hair_follicle_companion	0.18	Nonsignificant	—	0.36	Other	8	12
108	EPI.thymic_cortical	0.16	Nonsignificant	1.00	0.82	Other	442	824
109	EPI.renal_thick_ascending_limb	0.16	Nonsignificant	1.00	0.83	Other	453	1,153
110	EPI.cervical_suprabasal	0.15	Nonsignificant	—	0.00	Other	14	50
111	EPI.colonic_tuft	0.14	Nonsignificant	—	0.35	Other	7	24
112	EC.arterial	0.13	Nonsignificant	0.25	1.04	Other	356	885
113	EPI.renal_principal_cell	0.10	Nonsignificant	1.00	0.76	Other	207	403
114	FIB.adventitial	0.10	Nonsignificant	1.00	0.25	Other	268	1,447
115	FIB.tracheal_subepithelial	0.09	Nonsignificant	—	0.00	Other	0	0
116	EPI.renal_intercalated_cell_type_A	0.08	Nonsignificant	1.00	0.73	Other	67	142
117	EPI.salivary_duct_ion_transport	0.05	Nonsignificant	1.00	0.71	Other	5	11
118	EPI.renal_immature_ureteric_bud	0.05	Nonsignificant	1.00	0.85	Other	217	569
119	EPI.endocervical_secretory	0.04	Nonsignificant	—	0.03	Other	0	0
120	MESO.mesothelial_cell	0.04	Nonsignificant	—	—	Other	2	18
121	EC.capillary	0.03	Nonsignificant	1.00	0.89	Other	514	1,635
122	EPI.esophageal_basal	0.03	Nonsignificant	1.00	0.67	Other	4	10
123	EPI.skin_keratinocyte_progenitor	0.02	Nonsignificant	—	0.00	Other	0	3
124	CM.cardiomyocyte	0.02	Nonsignificant	—	—	Other	524	2,032
125	EPI.salivary_myoepithelial	0.02	Nonsignificant	1.00	0.61	Other	191	714
126	EPI.skin_appendage_keratinocyte	0.01	Nonsignificant	1.00	0.64	Other	87	222
127	EPI.tracheal_basal	0.01	Nonsignificant	1.00	0.55	Other	398	1,120
128	EPI.salivary_intercalated_defense	0.01	Nonsignificant	1.00	0.58	Other	81	161
129	EPI.alveolar_type_1	8.69e-03	Nonsignificant	1.00	0.62	Other	26	101
130	EC.heart_remodeling	7.00e-03	Nonsignificant	1.00	0.65	Other	569	1,594
131	EPI.extrahepatic_cholangiocyte	5.78e-03	Nonsignificant	—	0.00	Other	37	71
132	EC.venous	4.47e-03	Nonsignificant	1.00	0.71	Other	516	1,387
133	EPI.thymic_medullary	3.86e-03	Nonsignificant	1.00	0.49	Other	26	133
134	EPI.pancreatic_acinar	3.04e-03	Nonsignificant	1.00	0.47	Other	429	1,475
135	EPI.renal_intercalated_cell_type_B	2.99e-03	Nonsignificant	—	0.00	Other	6	7
136	EPI.tracheal_suprabasal	2.98e-03	Nonsignificant	1.00	0.55	Other	29	56
137	PLAT.platelet	2.77e-03	Nonsignificant	—	0.00	Other	38	53
138	EPI.skin_sebaceous_duct_luminal	2.01e-03	Nonsignificant	1.00	0.43	Other	100	249
139	EPI.pancreatic_ductal_mucinous	7.78e-04	Nonsignificant	1.00	0.34	Other	219	430
140	CHOND.chondrocyte	7.04e-04	Nonsignificant	—	—	Other	519	730
141	EPI.pancreatic_ductal_perivascular	6.94e-04	Nonsignificant	1.00	0.43	Other	4	30
142	EPI.salivary_duct_excretory	4.60e-04	Nonsignificant	1.00	0.33	Other	85	180
143	HEP.acute_phase	4.49e-04	Nonsignificant	1.00	1.00	Other	1,441	3,641
144	EPI.salivary_serous_acinar	4.01e-04	Nonsignificant	1.00	0.36	Other	233	531
145	HEP.periportal_metabolic	3.80e-04	Nonsignificant	1.00	0.98	Other	1,750	4,427
146	EC.liver_sinusoidal	2.78e-04	Nonsignificant	1.00	0.29	Other	1,083	1,925
147	EPI.intrahepatic_cholangiocyte_defense	2.09e-04	Nonsignificant	—	0.00	Other	8	13
148	EPI.pancreatic_ductal_bicarbonate	1.68e-04	Nonsignificant	1.00	0.29	Other	131	548
149	EPI.pancreatic_ductal_progenitor	7.82e-05	Nonsignificant	1.00	0.39	Other	234	873
150	EPI.intrahepatic_cholangiocyte_transport	4.18e-05	Nonsignificant	—	0.00	Other	12	42
151	EPI.hepatic_ductular_cholangiocyte	3.14e-05	Nonsignificant	1.00	0.27	Other	83	243
152	HEP.canalicular_transport	4.24e-06	Nonsignificant	1.00	0.88	Other	1,290	3,434

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	DC.pDC.baseline	32.92	Significant	0.39	1.47	Specific	88	123
2	OPC.homeostatic	32.63	Significant	0.24	1.68	—	394	160
3	OPC.proliferative_immune_interact	29.53	Significant	0.98	0.71	Specific	180	373
4	DC.pDC.immature_metabolic	28.66	Significant	0.98	0.74	Specific	78	124
5	OPC.premyelinating	28.52	Significant	0.98	0.14	—	185	12
6	DC.pDC.poised_migratory	19.45	Significant	0.98	0.16	Relevant	54	95
7	T.MAIT.stress	17.47	Significant	—	2.15	—	0	0
8	EPI.colonic_enteroendocrine.progenitor	16.64	Significant	—	0.97	Relevant	0	0
9	T.CD8_transitional.stress	13.56	Significant	—	0.96	Relevant	24	34
10	MONO.CD14.APC_like	12.08	Significant	2.49e-11	1.72	Specific	1,686	2,493
11	B.memory.pDC_imprint	11.89	Significant	0.52	1.31	—	157	103
12	T.MAIT.cytotoxic	11.47	Significant	0.66	1.41	—	52	15
13	T.CD4_cytotoxic.precursor	11.23	Significant	0.20	1.87	—	156	67
14	B.memory.baseline	11.12	Significant	2.40e-05	2.11	—	472	99
15	T.MAIT.quiescent	10.98	Significant	0.73	1.12	—	100	5
16	T.MAIT.vesicle	10.82	Significant	0.66	1.31	Specific	37	65
17	T.CD4_Th17.cytotoxic	10.29	Significant	0.01	1.90	—	332	123
18	T.MAIT.early_activation	10.28	Significant	0.73	1.00	—	57	4
19	T.CD8_Tcm.gut_homing	9.88	Significant	0.04	1.80	—	380	112
20	T.gamma_delta.central_memory	9.77	Significant	2.84e-03	1.98	Specific	460	919
21	EPI.skin_interfollicular_spinous.upper_lipid	9.69	Significant	—	1.37	Relevant	6	6
22	T.MAIT.MAPK_brake	9.43	Significant	0.97	0.48	Relevant	44	66
23	T.CD4_cytotoxic.baseline	9.37	Significant	0.54	1.32	—	0	0
24	DC.cDC2.monocyte_like	9.22	Significant	3.27e-03	1.63	Specific	1,285	791
25	T.CD8_Tcm.effector_bias	9.13	Significant	0.13	1.51	Relevant	199	329
26	B.naive.purinergic	8.76	Significant	7.97e-04	1.81	Specific	384	820
27	T.CD4_cytotoxic.terminal_effector	8.50	Significant	0.54	1.06	—	286	21
28	T.CD4_Tem.long_term_memory	8.43	Significant	0.03	1.75	Specific	314	587
29	B.naive.receptor_recycle	8.27	Significant	0.56	1.33	—	51	0
30	B.naive.remodeling	8.23	Significant	0.56	1.24	Relevant	135	230
31	T.CD4_cytotoxic.NK_adapted	8.18	Significant	0.54	1.12	—	82	33
32	B.memory.activated	8.16	Significant	1.00	0.33	—	105	29
33	T.CD4_cytotoxic.activated	7.99	Significant	0.91	0.37	Relevant	3	1
34	B.germinal_center.LZ_survival	7.82	Significant	—	1.47	Relevant	0	0
35	NEU.EXC_CT.Ca2_sensor	7.74	Significant	—	1.13	Relevant	0	0
36	B.naive.antigen_presenting_ready	7.55	Significant	0.99	1.00	Relevant	48	73
37	T.MAIT.migratory	7.52	Significant	0.97	0.29	—	10	1
38	T.CD4_Tcm.secretory	7.50	Significant	0.12	1.79	Relevant	20	11
39	T.CD4_Tcm.effector_like	7.43	Significant	0.05	1.85	Relevant	293	533
40	B.memory.migratory	7.31	Significant	1.00	0.36	Relevant	123	208
41	T.CD4_Trm.metal_stress	7.21	Significant	0.17	1.68	Relevant	34	58
42	MAC.microglia_like.phagocytic_redox	7.19	Significant	—	0.69	Relevant	0	0
43	B.naive.baseline	7.19	Significant	0.99	0.69	Relevant	10	13
44	T.CD4_Tem.inflammatory	7.13	Significant	0.79	1.07	—	28	6
45	DC.cDC2.migratory	7.08	Significant	0.84	1.16	Other	185	39
46	B.naive.metabolic	7.03	Significant	0.99	0.66	Relevant	50	79
47	T.CD4_Tcm.stress	6.99	Significant	0.44	1.51	Relevant	5	11
48	THYMO.DP_early_stress	6.92	Significant	—	2.36	Relevant	0	0
49	T.gamma_delta.early_effector	6.92	Significant	1.00	0.63	—	89	0
50	T.CD4_naive.survival	6.91	Significant	0.84	1.05	Relevant	12	17
51	T.CD4_naive.mature_mitoprot	6.89	Significant	0.60	1.31	Specific	212	476
52	T.CD4_naive.neddylation_mitoprot	6.87	Significant	0.60	1.32	Specific	93	56
53	NEU.EXC_CT.Ca2_signaling	6.86	Significant	—	0.89	—	68	17
54	T.CD4_Tcm.RNA_control	6.83	Significant	0.44	1.32	—	96	4
55	B.naive.proteostasis	6.83	Significant	0.99	0.64	Relevant	49	69
56	T.CD4_naive.homeostatic	6.76	Significant	0.60	1.25	Specific	215	108
57	MONO.CD16.hepatic_mac_like	6.72	Significant	3.11e-03	1.56	Other	803	117
58	T.CD4_Th17.baseline	6.68	Significant	0.92	0.55	—	51	5
59	NEU.EXC_SYT2.nuclear_reg	6.56	Significant	—	0.97	Relevant	0	0
60	T.CD8_transitional.Trm_primed	6.55	Significant	3.28e-03	1.79	Other	108	15
61	T.CD8_Tcm.baseline	6.51	Significant	0.93	0.96	Relevant	90	89
62	T.CD4_naive.survival_neddylation	6.51	Significant	1.00	0.76	Relevant	26	38
63	T.CD4_naive.resist_bystander	6.50	Significant	0.60	1.35	Relevant	40	25
64	T.CD4_Tcm.baseline	6.49	Significant	0.44	1.28	Relevant	61	31
65	T.CD4_naive.survival_mitoprot	6.46	Significant	0.84	1.02	Relevant	13	7
66	T.CD4_naive.purinergic	6.45	Significant	0.84	1.15	—	49	1
67	T.CD4_Tcm.retro_ZNF117	6.44	Significant	0.86	1.01	Relevant	5	9
68	T.CD8_transitional.early	6.44	Significant	0.10	1.36	Relevant	327	55
69	PC.IgG_systemic.stress	6.44	Significant	—	1.00	Relevant	1	5
70	T.CD4_Tcm.DC_interact	6.43	Significant	0.44	1.26	Relevant	72	32
71	T.CD4_naive.mature	6.39	Significant	0.84	1.06	Specific	211	100
72	T.CD4_Tcm.regulatory_poised	6.37	Significant	0.44	1.30	—	2	3
73	T.CD4_naive.neddylation	6.33	Significant	1.00	0.92	Specific	104	222
74	MONO.CD16.inflammatory	6.28	Significant	2.44e-05	1.63	Other	1,640	168
75	EPI.bile_duct_cholangiocyte.secretory_mucin	6.26	Significant	—	0.76	Relevant	7	12
76	T.CD4_Tcm.imprinted_splicing	6.25	Significant	0.97	0.90	Relevant	6	17
77	T.CD4_Tem.transitional_CM	6.25	Significant	0.93	0.69	—	31	20
78	B.memory.preactivated	6.14	Significant	1.00	0.34	—	173	174
79	T.CD8_naive.mito_proteostasis	6.08	Significant	3.18e-03	2.31	Specific	428	100
80	SKM.type_2_fast.oxidative_IIa	6.05	Significant	0.03	2.02	—	946	56
81	T.CD4_Tcm.synapse_dynamics	6.03	Significant	1.00	0.61	Relevant	15	10
82	T.gamma_delta.cytotoxic_effector	5.89	Significant	1.00	0.32	Other	349	109
83	T.CD8_Tem.stress_adapted	5.88	Significant	0.27	1.32	Relevant	607	520
84	T.CD4_Tcm.migratory_cilium	5.87	Significant	1.00	0.68	Relevant	5	10
85	B.naive.activated	5.82	Significant	0.99	0.46	Relevant	77	127
86	T.CD4_Tcm.crosstalk_myeloid	5.75	Significant	0.74	1.12	Relevant	5	4
87	SKM.type_2_fast.glycolytic_IIx_IIb	5.73	Significant	0.74	0.71	Specific	565	1,482
88	B.age_associated.naive_transitional	5.73	Significant	—	0.73	Relevant	0	0
89	T.CD4_Th17.migratory	5.72	Significant	0.92	0.60	Other	13	23
90	NEU.INH_PVALB.serotonergic	5.61	Significant	—	0.84	Relevant	0	0
91	NK.adaptive_terminal_cytotoxic	5.55	Significant	9.19e-07	2.77	Specific	485	802
92	T.CD4_naive.proteostasis_mitoprot	5.54	Significant	1.00	0.34	Other	15	37
93	T.CD8_Tem.motility_primed	5.51	Significant	0.27	1.35	Relevant	269	4
94	T.CD8_Tem.early_helper_like	5.49	Nominal	0.27	1.35	Other	445	755
95	T.CD4_naive.Treg_like	5.46	Nominal	1.00	0.49	Other	121	72
96	NEU.INH_PVALB.neuromodulatory	5.40	Nominal	—	0.72	Relevant	0	0
97	PC.IgG_systemic.interacting	5.40	Nominal	0.43	1.18	Other	0	0
98	T.CD4_Tcm.tissue_homing	5.40	Nominal	1.00	0.50	Other	78	46
99	DC.cDC2.adhesion_signaling	5.39	Nominal	0.91	1.01	Other	35	9
100	T.CD8_Tem.signaling_turnover	5.37	Nominal	0.27	1.54	Other	425	683
101	T.CD4_Tem.cytotoxic_effector	5.30	Nominal	0.93	0.59	Other	225	398
102	B.age_associated.migratory	5.28	Nominal	0.57	0.98	Other	2	2
103	NK.cytokine_tissue_resident	5.27	Nominal	2.11e-03	2.31	Other	74	82
104	NEU.INH_VIP.cannabinoid	5.24	Nominal	—	1.91	Other	0	0
105	MAC.microglia_like.inflammatory_chemokine	5.23	Nominal	—	0.26	Other	20	32
106	T.CD4_Tcm.Tfh_like	5.23	Nominal	1.00	0.39	Other	102	214
107	NEU.EXC_IT.transitional	5.18	Nominal	0.02	1.87	Other	237	142
108	NEU.INH_PVALB.fastspike	5.16	Nominal	—	0.80	Other	24	22
109	NEU.EXC_CT.remodeling	5.11	Nominal	—	0.00	Other	23	1
110	T.CD4_naive.proteostasis	5.11	Nominal	1.00	0.28	Other	14	9
111	OLG.myelinating_mature	5.09	Nominal	1.28e-13	2.50	Other	363	94
112	NEU.EXC_CT.projector	5.04	Nominal	0.96	0.02	Other	87	26
113	T.CD8_Tem.baseline	5.02	Nominal	1.00	0.69	Other	458	356
114	SCHWN.axon_contact_cardiac	4.99	Nominal	0.21	1.44	Other	18	63
115	MONO.CD14.remodeling	4.96	Nominal	0.03	1.19	Other	2,373	295
116	PERI.inflammatory	4.93	Nominal	0.01	1.70	Other	40	77
117	T.CD8_transitional.effector_primed	4.92	Nominal	0.82	0.94	Other	435	151
118	T.CD4_Tcm.APC_mimicry	4.80	Nominal	1.00	0.16	Other	54	43
119	B.germinal_center.LZ_selection	4.73	Nominal	—	0.00	Other	0	0
120	B.germinal_center.LZ_memory_precursor	4.72	Nominal	—	0.00	Other	0	0
121	T.CD4_Trm.baseline	4.71	Nominal	0.62	1.17	Other	31	21
122	NK.adaptive_axis_baseline	4.67	Nominal	4.22e-07	2.64	Other	1,008	153
123	NK.adaptive_immature_precursor	4.61	Nominal	1.19e-03	2.27	Other	358	111
124	T.CD8_Tem.TEMRA	4.59	Nominal	1.00	0.20	Other	920	1,088
125	SCHWN.reactive_inflammatory	4.56	Nominal	—	0.00	Other	0	0
126	NEU.EXC_IT.neuromodulated	4.56	Nominal	0.05	1.70	Other	176	116
127	B.germinal_center.DZ_S_phase	4.54	Nominal	—	0.00	Other	0	0
128	T.CD4_Trm.helper_like	4.50	Nominal	0.62	1.10	Other	84	147
129	NK.adaptive_classII_inhibitory	4.48	Nominal	2.11e-03	2.12	Other	880	154
130	NEU.EXC_IT.adhesion	4.48	Nominal	0.05	1.69	Other	252	108
131	NK.adaptive_HLAE_tuned	4.44	Nominal	2.11e-03	1.94	Other	1,124	189
132	OLG.vesicle_trafficking	4.43	Nominal	0.25	1.39	Other	124	10
133	T.CD8_Tcm.helper_like	4.41	Nominal	1.00	0.06	Other	81	159
134	T.CD4_Tcm.Th2_like	4.41	Nominal	1.00	0.25	Other	23	55
135	OLG.myelinating_stress	4.39	Nominal	0.25	1.38	Other	232	62
136	T.CD8_transitional.APC_like	4.36	Nominal	1.00	0.29	Other	205	62
137	T.CD4_Trm.activated	4.35	Nominal	0.62	1.26	Other	32	26
138	EPI.skin_interfollicular_spinous.stress_UPR	4.32	Nominal	—	1.04	Other	0	0
139	SCHWN.translation_boost	4.31	Nominal	—	0.00	Other	8	1
140	DC.cDC2.antiviral	4.26	Nominal	0.91	0.96	Other	100	37
141	NK.adaptive_adipose_stress	4.24	Nominal	0.36	1.31	Other	374	39
142	B.naive.restrained	4.22	Nominal	0.99	0.47	Other	183	353
143	NK.adaptive_biosynthetic_primed	4.18	Nominal	0.11	1.66	Other	244	405
144	NEU.INH_PVALB.nuclear_reg	4.08	Nominal	1.00	0.80	Other	25	12
145	NK.cytokine_tissue_activation	4.06	Nominal	0.63	1.14	Other	267	450
146	T.CD4_transitional.primed_cytotoxic	4.00	Nominal	0.54	1.24	Other	28	30
147	PC.IgG_systemic.secretory	3.95	Nominal	0.43	1.20	Other	0	0
148	T.CD8_naive.baseline	3.94	Nominal	0.04	1.64	Other	142	2
149	PC.IgA_muocsal.activated	3.84	Nominal	2.25e-03	1.66	Other	17	8
150	ILC2.quiescent	3.82	Nominal	—	0.80	Other	0	0
151	NK.cytokine_vascular_patrolling	3.81	Nominal	0.99	0.82	Other	863	94
152	OLG.reactive_repair	3.79	Nominal	0.60	1.12	Other	385	385
153	T.CD8_naive.vesicle_secretory	3.65	Nominal	0.98	0.82	Other	42	0
154	T.CD8_Trm.inflammatory	3.63	Nominal	0.59	1.21	Other	124	176
155	T.CD8_naive.cytokine_dampened	3.63	Nominal	0.84	1.08	Other	71	4
156	NEU.INH_PVALB.metabotropic	3.63	Nominal	—	0.00	Other	0	0
157	NK.cytokine_quiescent	3.61	Nominal	1.00	0.60	Other	623	1,062
158	T.CD4_transitional.baseline	3.59	Nominal	0.54	1.19	Other	59	97
159	B.age_associated.activated	3.58	Nominal	—	0.00	Other	18	22
160	EPI.skin_interfollicular_spinous.baseline	3.55	Nominal	0.45	1.45	Other	35	3
161	T.CD8_naive.nfkb_related	3.54	Nominal	0.84	1.15	Other	1	0
162	NK.cytokine_repair_primed	3.50	Nominal	0.99	0.86	Other	266	11
163	B.germinal_center.DZ_M_phase	3.49	Nominal	—	0.00	Other	0	0
164	T.CD8_naive.innate_like	3.48	Nominal	0.98	0.83	Other	10	1
165	MONO.CD14.platelet_bound	3.48	Nominal	0.02	1.42	Other	964	176
166	PC.IgG_systemic.metabolic	3.45	Nominal	0.43	1.16	Other	46	63
167	T.CD8_Trm.dendritic_recruiter	3.44	Nominal	0.59	1.13	Other	47	85
168	T.CD4_Trm.cytotoxic_effector	3.40	Nominal	0.97	0.83	Other	118	77
169	T.CD8_naive.lipid_synthesis	3.37	Nominal	0.98	0.70	Other	6	4
170	NK.cytokine_biosynthetic_primed	3.36	Nominal	0.99	0.74	Other	360	21
171	T.CD8_Trm.cytotoxic	3.36	Nominal	0.59	1.09	Other	165	85
172	PERI.cardiac_skeletal	3.31	Nominal	0.02	1.50	Other	313	630
173	NK.cytokine_axis_baseline	3.25	Nominal	1.00	0.43	Other	1,172	116
174	T.CD8_naive.effector_transition	3.24	Nominal	0.98	0.46	Other	35	62
175	T.CD8_naive.splicing_enriched	3.22	Nominal	0.98	0.44	Other	120	16
176	NEU.INH_VIP.develop_niche	3.22	Nominal	—	1.08	Other	0	0
177	EPI.ileal_enterocyte_absorptive.brush_border	3.21	Nominal	5.88e-04	2.61	Other	580	1,717
178	T.CD8_Tcm.NK_like	3.20	Nominal	1.00	0.12	Other	334	581
179	T.CD4_naive.gut_prone	3.18	Nominal	1.00	4.86e-03	Other	35	70
180	MAC.resident_iron.APC_iron_sensing	3.18	Nominal	1.33e-03	1.93	Other	211	114
181	EPI.skin_interfollicular_spinous.early_differentiation	3.13	Nominal	0.79	0.99	Other	89	19
182	OLG.regulatory_activated	3.12	Nominal	1.00	0.26	Other	196	614
183	ASTRO.A1_reactive	3.07	Nominal	0.05	1.43	Other	433	394
184	OLG.stress	3.07	Nominal	1.00	0.17	Other	232	8
185	T.CD4_Trm.central_like	2.98	Nonsignificant	0.97	0.53	Other	38	31
186	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	2.97	Nonsignificant	—	1.52	Other	0	0
187	NEU.INH_VIP.matrix	2.97	Nonsignificant	—	1.20	Other	24	77
188	MONO.CD14.baseline	2.95	Nonsignificant	1.00	0.64	Other	2,268	76
189	T.CD8_Trm.homeostatic	2.95	Nonsignificant	0.84	0.73	Other	42	5
190	FIB.skin_papillary.baseline	2.90	Nonsignificant	—	0.00	Other	0	0
191	NEU.INH_PVALB.chandelier	2.85	Nonsignificant	1.00	0.00	Other	19	16
192	GRANU.MAST.activated_acute	2.84	Nonsignificant	—	1.28	Other	0	0
193	T.CD8_Trm.muscosal_Tc17	2.84	Nonsignificant	0.84	0.75	Other	19	38
194	MG.phagocytic_APC	2.75	Nonsignificant	0.23	1.60	Other	25	8
195	PERI.baseline	2.75	Nonsignificant	0.99	0.64	Other	39	66
196	OLG.regulatory	2.75	Nonsignificant	1.00	0.07	Other	353	73
197	FIB.skin_sheath.stress_chaperone	2.68	Nonsignificant	—	0.35	Other	0	0
198	FIB.skin_sheath.neuro_vascular_interface	2.66	Nonsignificant	—	0.44	Other	0	0
199	EC.lymphatic.activated	2.65	Nonsignificant	0.30	1.16	Other	47	73
200	EPI.ileal_bile_transport.absorptive_xenobiotic	2.65	Nonsignificant	0.57	0.92	Other	11	12
201	PC.IgA_muocsal.migratory	2.64	Nonsignificant	0.93	0.75	Other	4	1
202	T.CD4_Th2.tissue_adapted	2.63	Nonsignificant	—	0.97	Other	0	0
203	DC.cDC2.tolerogenic_regulatory	2.61	Nonsignificant	1.00	0.54	Other	44	4
204	NEU.EXC_IT.guidance	2.61	Nonsignificant	1.00	0.51	Other	274	63
205	NK.cytokine_lung_immediate_early	2.57	Nonsignificant	1.00	0.17	Other	424	274
206	NEU.EXC_IT.callosal	2.56	Nonsignificant	1.00	0.69	Other	286	119
207	EPI.ileal_bile_transport.detox_transcytosis	2.55	Nonsignificant	—	0.00	Other	0	1
208	T.CD4_transitional.primed_helper_effector	2.55	Nonsignificant	0.98	0.76	Other	19	43
209	ASTRO.neuromodulatory	2.53	Nonsignificant	1.00	1.15	Other	34	172
210	THYMO.SP_CD8_naive_stress	2.53	Nonsignificant	0.11	1.66	Other	1	1
211	T.CD4_Tfh.effector_migratory	2.50	Nonsignificant	0.07	1.61	Other	122	57
212	GRNLSA.lipid_hypoxia	2.48	Nonsignificant	0.11	1.63	Other	28	0
213	FIB.skin_tenogenic.baseline	2.48	Nonsignificant	—	0.00	Other	0	2
214	PC.IgA_muocsal.baseline	2.41	Nonsignificant	0.93	0.68	Other	3	5
215	EPI.ileal_enterocyte_absorptive.villus_tip	2.40	Nonsignificant	1.00	0.00	Other	4	3
216	MAC.microglia_like.patrolling_adhesive	2.38	Nonsignificant	—	0.00	Other	0	0
217	MONO.CD16.baseline	2.36	Nonsignificant	1.00	0.74	Other	50	1
218	T.CD4_Treg.central_naive_like	2.35	Nonsignificant	1.09e-04	1.65	Other	333	45
219	PERI.angiocrine	2.34	Nonsignificant	0.99	0.43	Other	93	102
220	EC.lymphatic.tip_migratory	2.31	Nonsignificant	0.29	1.25	Other	23	37
221	THYMO.SP_CD8_transitional	2.31	Nonsignificant	6.27e-05	2.20	Other	32	75
222	EPI.renal_distal_tubule.ion_transport	2.30	Nonsignificant	—	1.02	Other	0	0
223	GRNLSA.p53_damage	2.30	Nonsignificant	—	0.72	Other	13	10
224	ASTRO.stress_acute	2.27	Nonsignificant	1.00	1.06	Other	60	56
225	T.CD4_Trm.stress_adaptive	2.21	Nonsignificant	0.97	0.41	Other	8	22
226	PC.IgA_muocsal.plasmablast	2.21	Nonsignificant	0.93	0.72	Other	5	4
227	T.CD4_transitional.APC_interacting	2.15	Nonsignificant	0.98	0.54	Other	10	14
228	SMC.activated	2.14	Nonsignificant	0.13	1.42	Other	2	5
229	FIB.skin_neurosecretory.baseline	2.13	Nonsignificant	—	0.00	Other	0	0
230	GRNLSA.cholesterol_mevalonate	2.12	Nonsignificant	0.56	1.23	Other	9	4
231	FIB.skin_sheath.ECM_immune	2.06	Nonsignificant	—	0.00	Other	0	0
232	ASTRO.synaptic_interaction	2.05	Nonsignificant	1.00	0.96	Other	76	334
233	MG.expanding	2.03	Nonsignificant	0.90	0.61	Other	2	1
234	T.CD4_Treg.Tr1_like	2.03	Nonsignificant	—	0.75	Other	8	8
235	T.CD4_naive.activated_stress	2.00	Nonsignificant	1.00	0.00	Other	339	429
236	EPI.skin_interfollicular_spinous.stress_oxidative	2.00	Nonsignificant	—	0.00	Other	0	0
237	T.CD4_Tfh.precursor_migratory	1.99	Nonsignificant	0.96	1.02	Other	72	27
238	MAC.resident_iron.stress_tolerogenic	1.97	Nonsignificant	—	0.25	Other	0	0
239	MG.baseline	1.96	Nonsignificant	0.90	0.51	Other	16	5
240	EPI.skin_interfollicular_spinous.inflammatory	1.93	Nonsignificant	—	0.00	Other	0	0
241	NEU.INH_VIP.nuclear_reg	1.91	Nonsignificant	—	0.53	Other	20	4
242	DC.cDC2.proliferative	1.89	Nonsignificant	—	0.00	Other	39	71
243	MAC.LAM.inflammatory_APC	1.88	Nonsignificant	4.60e-04	1.58	Other	872	165
244	MAC.alveolar.biosynthetic_sterol_heme	1.86	Nonsignificant	4.75e-03	1.83	Other	347	40
245	DC.cDC1.homeostatic_inhibitory	1.86	Nonsignificant	—	1.01	Other	0	0
246	FIB.reticular.ECM_builder	1.86	Nonsignificant	—	0.28	Other	0	0
247	T.CD4_Th2.precursor	1.84	Nonsignificant	—	0.00	Other	0	0
248	ASTRO.immature_lipid	1.83	Nonsignificant	1.00	0.86	Other	23	113
249	MAC.LAM.antimicrobial	1.79	Nonsignificant	0.23	1.27	Other	389	93
250	SMC.metabolic	1.79	Nonsignificant	0.56	1.08	Other	14	40
251	DC.cDC1.proliferative	1.79	Nonsignificant	—	0.89	Other	0	0
252	MONO.CD16.patrolling	1.75	Nonsignificant	1.00	0.33	Other	797	216
253	GRNLSA.EMT_insulin_signaling	1.75	Nonsignificant	0.37	1.42	Other	47	84
254	SKM.type_1_slow.glycolytic	1.68	Nonsignificant	4.06e-03	2.10	Other	362	647
255	MONO.CD14.repair_M2_like	1.67	Nonsignificant	1.00	0.39	Other	550	1,495
256	MAC.LAM.lipid_opsonization	1.66	Nonsignificant	1.00	0.87	Other	45	14
257	ASPC.adipocyte_capillary_interface	1.62	Nonsignificant	0.09	1.66	Other	21	54
258	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	1.61	Nonsignificant	—	0.00	Other	0	0
259	NK.immature_bridge	1.60	Nonsignificant	1.00	0.00	Other	117	122
260	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.59	Nonsignificant	—	0.92	Other	0	0
261	EPI.ileal_enterocyte_crypt.villus_transition	1.59	Nonsignificant	—	0.80	Other	7	10
262	MAC.resident_cardiac.antigen_presenting	1.58	Nonsignificant	0.21	1.74	Other	52	27
263	ILC2.activated	1.58	Nonsignificant	—	0.23	Other	0	0
264	EPI.lung_club_secretory.ciliogenesis_axoneme	1.55	Nonsignificant	—	1.13	Other	0	0
265	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.53	Nonsignificant	—	0.82	Other	29	88
266	EC.lymphatic.baseline	1.52	Nonsignificant	0.64	0.99	Other	38	72
267	FIB.suburothelial.homeostasis_matrix	1.48	Nonsignificant	0.30	1.56	Other	258	921
268	NEU.EXC_IT.structural	1.47	Nonsignificant	1.00	0.00	Other	171	41
269	DC.cDC2.pro_inflammatory	1.44	Nonsignificant	1.00	0.18	Other	3	5
270	IPSC.mesodermal_primed	1.43	Nonsignificant	0.64	1.14	Other	0	0
271	NEU.INH_VIP.excitatory_coupled	1.42	Nonsignificant	—	0.00	Other	13	0
272	EPI.skin_interfollicular_spinous.transition_basal	1.42	Nonsignificant	1.00	0.00	Other	100	127
273	EPI.skin_interfollicular_spinous.proliferative	1.41	Nonsignificant	—	0.00	Other	0	0
274	NEU.INH_VIP.LAMP5_hybrid	1.41	Nonsignificant	—	0.00	Other	1	9
275	GRANU.neutrophil.antiviral_endotoxin	1.40	Nonsignificant	—	0.90	Other	0	0
276	NEU.EXC_SYT2.synaptic	1.40	Nonsignificant	—	0.00	Other	0	0
277	MEL.secretory_quiescent	1.37	Nonsignificant	0.03	1.91	Other	19	13
278	MAC.resident_iron.heme_catabolism	1.35	Nonsignificant	0.99	0.52	Other	30	51
279	FIB.suburothelial.contractile_myofibroblast	1.34	Nonsignificant	—	0.08	Other	9	0
280	MAC.alveolar.stress_metabolic	1.32	Nonsignificant	0.59	1.16	Other	116	148
281	FIB.suburothelial.urothelial_interface	1.32	Nonsignificant	0.60	0.84	Other	9	8
282	IPSC.mesendo_primed	1.31	Nonsignificant	2.80e-11	1.32	Other	0	0
283	NEU.INH_VIP.canonical_disinhibitory	1.31	Nonsignificant	0.97	0.18	Other	59	38
284	EPI.ectocervical_granular.secretory_apocrine	1.25	Nonsignificant	—	1.15	Other	0	0
285	ASTRO.hypoxia_angiogenic	1.24	Nonsignificant	1.00	0.63	Other	5	18
286	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.24	Nonsignificant	—	0.87	Other	135	290
287	NEU.INH_VIP.opioid	1.24	Nonsignificant	—	0.00	Other	50	9
288	MAC.resident_repair.antigen_presenting	1.22	Nonsignificant	0.22	1.56	Other	244	113
289	T.CD4_transitional.tissue_enagement	1.19	Nonsignificant	0.98	0.38	Other	5	11
290	NEU.INH_VIP.serotonergic	1.18	Nonsignificant	—	0.00	Other	9	2
291	MAC.MDM.complement_resolving	1.18	Nonsignificant	0.39	1.07	Other	440	860
292	EPI.alveolar_type_2.injury_primed	1.17	Nonsignificant	1.61e-05	2.26	Other	434	245
293	MONO.CD14.cord_tolerance	1.15	Nonsignificant	1.00	0.33	Other	864	753
294	EPI.ileal_enterocyte_crypt.secretory_precursor	1.15	Nonsignificant	—	0.25	Other	0	0
295	GRANU.neutrophil.tissue_patrolling	1.14	Nonsignificant	—	0.00	Other	0	0
296	GRNLSA.stress_metabolic	1.14	Nonsignificant	—	0.00	Other	1	2
297	GRNLSA.chemokine_mechanosensory	1.13	Nonsignificant	0.97	0.65	Other	1	0
298	EPI.ileal_enterocyte_crypt.baseline	1.12	Nonsignificant	0.55	0.95	Other	11	6
299	MAC.MDM.APC_dendritic	1.11	Nonsignificant	0.39	1.12	Other	48	15
300	MAC.resident_iron.heme_recycling	1.11	Nonsignificant	—	0.00	Other	30	37
301	GRANU.neutrophil.primed_degranulation	1.11	Nonsignificant	—	0.00	Other	0	0
302	SMC.contractile	1.11	Nonsignificant	1.00	0.32	Other	80	588
303	THYMO.SP_CD8_naive	1.10	Nonsignificant	1.54e-03	1.72	Other	297	177
304	EPI.renal_distal_tubule.repair	1.10	Nonsignificant	—	0.00	Other	34	102
305	SKM.type_1_slow.contractile	1.08	Nonsignificant	0.52	1.13	Other	596	8
306	EPI.ileal_enterocyte_crypt.bile_transport	1.08	Nonsignificant	0.55	0.98	Other	2	0
307	NEU.INH_VIP.regulatory_remodeling	1.07	Nonsignificant	—	0.00	Other	6	1
308	MONO.CD16.platelet_bound	1.06	Nonsignificant	1.00	0.45	Other	372	508
309	FIB.suburothelial.inflammatory_prostanoid	1.05	Nonsignificant	—	0.00	Other	0	0
310	GRNLSA.secretory_remodeling	1.03	Nonsignificant	0.97	0.39	Other	90	25
311	T.CD4_Tfh.canonical_GC_helper	1.01	Nonsignificant	0.97	0.33	Other	1	2
312	FIB.hepatic_stellate_cell.contractile	1.01	Nonsignificant	—	1.15	Other	0	0
313	MAC.resident_iron.redox_metabolic	1.00	Nonsignificant	0.99	0.15	Other	4	4
314	GRANU.MAST.resting_granule	0.98	Nonsignificant	—	0.00	Other	0	0
315	FIB.interstitial.stress_secretory	0.98	Nonsignificant	0.37	1.33	Other	92	56
316	DC.cDC2.lipid_metabolic	0.96	Nonsignificant	—	0.00	Other	0	0
317	NEU.INH_LAMP5.projecting	0.96	Nonsignificant	—	1.34	Other	0	0
318	ADIPO.thermogenic	0.96	Nonsignificant	—	1.28	Other	0	0
319	MAC.MDM.LAM_like	0.96	Nonsignificant	0.39	1.13	Other	12	14
320	GRNLSA.proliferative_migratory	0.95	Nonsignificant	0.97	0.41	Other	248	292
321	SKM.type_1_slow.oxidative	0.95	Nonsignificant	0.89	0.55	Other	802	251
322	ILC2.migratory	0.95	Nonsignificant	—	0.00	Other	0	0
323	EPI.lung_multiciliated.mature_motile_cilia	0.92	Nonsignificant	—	0.89	Other	0	0
324	MAC.MDM.inflammatory_phagocytic	0.92	Nonsignificant	0.39	1.12	Other	199	52
325	MUSC.quiescent_reservoir	0.91	Nonsignificant	0.20	1.49	Other	2	8
326	GRANU.MAST.activated_repair	0.90	Nonsignificant	—	0.00	Other	0	1
327	EPI.colonocyte.secretory_boost	0.90	Nonsignificant	0.23	1.57	Other	98	91
328	EPI.lung_multiciliated.baseline	0.89	Nonsignificant	—	0.00	Other	0	7
329	NEU.INH_VIP.enkephalinergic	0.88	Nonsignificant	—	0.00	Other	0	0
330	FIB.hepatic_stellate_cell.inflammatory	0.88	Nonsignificant	—	0.32	Other	0	0
331	EPI.lung_multiciliated.stress	0.88	Nonsignificant	—	0.00	Other	67	165
332	MAC.resident_cardiac.phagocytic_homeostasis	0.88	Nonsignificant	0.89	0.72	Other	564	1,221
333	MEL.stress_glucocorticoid	0.87	Nonsignificant	0.63	1.01	Other	11	34
334	FIB.reticular.immune_interface	0.87	Nonsignificant	—	0.00	Other	1	6
335	T.CD4_Tfh.suppression_exhaustion	0.87	Nonsignificant	0.97	0.69	Other	0	2
336	FIB.reticular.stromal_niche	0.87	Nonsignificant	0.40	1.13	Other	0	0
337	MAC.resident_repair.chemokine_angiocrine	0.84	Nonsignificant	0.98	0.74	Other	87	138
338	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.84	Nonsignificant	—	0.00	Other	2	0
339	DC.mig.baseline	0.83	Nonsignificant	—	0.00	Other	1	0
340	MAC.resident_repair.ECM_stromal_crosstalk	0.83	Nonsignificant	0.98	0.91	Other	95	158
341	EPI.colonocyte.ionocyte_BEST4	0.83	Nonsignificant	0.23	1.64	Other	103	188
342	FIB.barrier_purinergic.lipid_secretory	0.82	Nonsignificant	—	0.48	Other	0	0
343	EPI.ileal_goblet.immature	0.82	Nonsignificant	—	1.32	Other	0	0
344	MAC.alveolar.scavenging_endocytic	0.81	Nonsignificant	—	0.00	Other	140	283
345	THYMO.DN_preTCR	0.81	Nonsignificant	0.96	0.53	Other	41	71
346	EPI.colonocyte.distal_absorptive	0.81	Nonsignificant	—	0.59	Other	0	0
347	MAC.resident_repair.lipid_phagocytic	0.80	Nonsignificant	0.98	0.73	Other	228	604
348	FIB.interstitial.mesenchymal_APC	0.79	Nonsignificant	0.19	1.40	Other	81	33
349	EPI.colonocyte.goblet_interface	0.78	Nonsignificant	—	0.27	Other	11	21
350	MAC.proliferating.stress	0.76	Nonsignificant	—	0.54	Other	87	136
351	HPC.MPP_IEG	0.75	Nonsignificant	0.41	1.24	Other	45	46
352	THYMO.DP_early	0.75	Nonsignificant	0.96	0.59	Other	326	313
353	THYMO.SP_CD4_naive	0.74	Nonsignificant	0.82	0.99	Other	65	75
354	EPI.ileal_enterocyte_crypt.proliferative_S	0.74	Nonsignificant	0.55	1.10	Other	4	2
355	MUSC.activated_migratory	0.74	Nonsignificant	0.20	1.61	Other	6	7
356	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.74	Nonsignificant	—	0.00	Other	19	54
357	EPI.alveolar_type_2.stress_response	0.73	Nonsignificant	0.72	0.81	Other	675	1,562
358	MUSC.baseline	0.73	Nonsignificant	0.53	1.11	Other	0	0
359	FIB.neurolectin_mucosa.inflammatory	0.73	Nonsignificant	0.17	1.59	Other	52	110
360	FIB.hepatic_stellate_cell.fibrogenic	0.72	Nonsignificant	—	0.00	Other	0	0
361	FIB.transitioning.matrix_stress	0.69	Nonsignificant	—	0.63	Other	47	138
362	FIB.neurolectin_mucosa.axon_responsive	0.69	Nonsignificant	0.17	1.55	Other	10	10
363	MAC.alveolar.lipid_autophagy	0.69	Nonsignificant	—	0.00	Other	35	44
364	ASTRO.stress_mito	0.69	Nonsignificant	1.00	0.47	Other	47	110
365	DC.cDC1.cross_presenting	0.69	Nonsignificant	—	0.00	Other	0	0
366	EPI.pancreatic_islet.delta	0.68	Nonsignificant	—	1.04	Other	0	0
367	MAC.kupffer.monocyte_like	0.68	Nonsignificant	—	1.12	Other	0	0
368	EPI.alveolar_type_2.baseline_surfactant	0.68	Nonsignificant	0.36	1.27	Other	64	9
369	EPI.gastric_foveolar.baseline	0.67	Nonsignificant	—	0.00	Other	0	0
370	EPI.renal_proximal_tubule.detox_antioxidant	0.67	Nonsignificant	0.05	2.20	Other	394	77
371	FIB.reticular.stress_metallothionein	0.65	Nonsignificant	—	0.00	Other	3	32
372	MAC.alveolar.inflammatory	0.65	Nonsignificant	0.91	0.86	Other	208	312
373	MAC.kupffer.tolerogenic	0.65	Nonsignificant	—	1.12	Other	45	49
374	ASTRO.A2_reactive	0.65	Nonsignificant	1.00	0.43	Other	10	37
375	MEL.dedifferentiated_migratory	0.64	Nonsignificant	—	0.00	Other	0	0
376	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.64	Nonsignificant	—	0.10	Other	43	26
377	NEU.INH_LAMP5.rosehip	0.64	Nonsignificant	—	0.40	Other	0	0
378	FIB.barrier_secretory.homeostasis	0.64	Nonsignificant	—	0.17	Other	0	0
379	EPI.renal_thick_ascending_limb.barrier_repair	0.63	Nonsignificant	0.29	1.20	Other	141	284
380	DC.cDC1.activated	0.63	Nonsignificant	—	0.00	Other	0	0
381	EPI.skin_sweat_duct_keratinocyte.repair	0.63	Nonsignificant	—	0.18	Other	0	0
382	FIB.neurolectin_mucosa.nerve_interface	0.61	Nonsignificant	—	0.00	Other	4	0
383	MEL.mature_oxidative_traffic	0.60	Nonsignificant	0.99	0.12	Other	247	285
384	HEP.pericentral_lipoprotein.ApoB_coagulation	0.60	Nonsignificant	—	0.67	Other	0	0
385	EPI.tracheal_submucosal_gland.acinar_serous	0.60	Nonsignificant	—	0.73	Other	0	0
386	FIB.adventitial.adhesion_lipid	0.57	Nonsignificant	1.99e-03	1.40	Other	58	209
387	EPI.ectocervical_granular.inflammatory	0.57	Nonsignificant	—	0.32	Other	0	0
388	HEP.pericentral_lipoprotein.UPR_redox	0.56	Nonsignificant	—	0.00	Other	0	0
389	HPC.GMP_inflammatory	0.56	Nonsignificant	0.20	1.40	Other	20	10
390	FIB.interstitial.immune_interact	0.55	Nonsignificant	0.44	1.17	Other	12	1
391	FIB.neurolectin_mucosa.remodeling_repair	0.54	Nonsignificant	—	0.00	Other	4	2
392	NEU.INH_LAMP5.exc_inh_balance	0.53	Nonsignificant	—	0.00	Other	46	2
393	T.CD4_Treg.APC_interactive	0.53	Nonsignificant	0.99	0.52	Other	118	28
394	EPI.renal_distal_tubule.stress	0.53	Nonsignificant	—	0.14	Other	0	0
395	FIB.interstitial.mesenchymal_regulator	0.53	Nonsignificant	0.84	0.97	Other	4	4
396	NEU.EXC_NTNG1.nuclear_reg	0.52	Nonsignificant	—	0.67	Other	0	0
397	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.52	Nonsignificant	1.00	0.00	Other	58	89
398	MONO.CD14.inflammatory	0.51	Nonsignificant	0.93	1.01	Other	92	134
399	FIB.perivascular_interface.vasomotor_tone	0.51	Nonsignificant	—	0.17	Other	0	0
400	EPI.colonocyte.crypt_progenitor	0.50	Nonsignificant	1.00	0.79	Other	115	265
401	MAC.resident_repair.stress_iron	0.49	Nonsignificant	0.98	0.18	Other	48	97
402	FIB.perivascular_interface.lipid_shuttle	0.49	Nonsignificant	—	0.05	Other	51	170
403	FIB.interstitial.lipid_matrix	0.48	Nonsignificant	0.90	0.87	Other	258	191
404	IPSC.axial_identity_primed	0.47	Nonsignificant	1.00	1.00	Other	0	0
405	EPI.skin_keratinocyte_basal.spinous_transition	0.47	Nonsignificant	—	0.97	Other	0	0
406	FIB.perivascular_interface.vascular_BM_remodelling	0.47	Nonsignificant	—	0.00	Other	0	0
407	THYMO.CD8aa_IELp	0.47	Nonsignificant	—	0.00	Other	1	7
408	ASPC.remodeling	0.46	Nonsignificant	0.34	1.27	Other	106	354
409	MUSC.early_activation	0.45	Nonsignificant	0.97	0.25	Other	4	32
410	NEU.INH_LAMP5.glial_interface	0.43	Nonsignificant	—	0.00	Other	0	0
411	ASPC.niche_keeping_progenitor	0.41	Nonsignificant	0.34	1.26	Other	52	219
412	EPI.skin_hair_follicle_bulge.quiescent	0.41	Nonsignificant	0.87	0.45	Other	56	69
413	HPC.CLP_B_primed	0.40	Nonsignificant	—	0.71	Other	0	0
414	EPI.skin_sweat_duct_keratinocyte.barrier	0.40	Nonsignificant	—	0.00	Other	0	0
415	EPI.skin_follicular_keratinizing.upper_infundibulum	0.40	Nonsignificant	—	0.58	Other	8	2
416	FIB.barrier_purinergic.stress_GF_binding	0.38	Nonsignificant	—	0.00	Other	0	0
417	ASPC.stem_like_progenitor	0.38	Nonsignificant	0.34	1.27	Other	300	842
418	EC.arterial.metabolic	0.38	Nonsignificant	0.12	1.13	Other	195	159
419	EPI.skin_keratinocyte_basal.transit_amplifying	0.37	Nonsignificant	—	0.00	Other	0	0
420	THYMO.proliferative_S	0.37	Nonsignificant	0.82	0.91	Other	163	418
421	T.CD4_Treg.tissue_effector	0.37	Nonsignificant	0.70	1.03	Other	16	13
422	MAC.LAM.lipid_phagocytosis	0.36	Nonsignificant	1.00	0.18	Other	369	328
423	EPI.colonocyte.junction_remodeling	0.36	Nonsignificant	1.00	0.18	Other	218	305
424	FIB.transitioning.motility_remodelling	0.35	Nonsignificant	—	0.00	Other	0	0
425	EPI.skin_follicular_keratinizing.root_infundibulum	0.35	Nonsignificant	—	6.94e-17	Other	0	0
426	MEL.neurotrophic_migratory	0.35	Nonsignificant	—	0.00	Other	0	0
427	EC.lymphatic.valve	0.34	Nonsignificant	—	0.04	Other	0	0
428	EPI.skin_hair_follicle_companion.activated_migratory	0.34	Nonsignificant	—	0.97	Other	0	0
429	MAC.resident_cardiac.inflammatory_reparative	0.33	Nonsignificant	0.89	0.46	Other	31	96
430	ASPC.activated	0.33	Nonsignificant	0.40	1.15	Other	164	162
431	HPC.GMP_granulocytic	0.32	Nonsignificant	—	0.53	Other	3	3
432	EPI.colonocyte.proximal_transport	0.32	Nonsignificant	1.00	0.04	Other	24	12
433	EPI.pancreatic_islet.alpha	0.32	Nonsignificant	—	0.24	Other	152	330
434	MAC.proliferating.DNA_replication	0.32	Nonsignificant	0.93	0.39	Other	3	6
435	ASPC.preadipocyte_lipid_primed	0.31	Nonsignificant	0.40	1.10	Other	331	129
436	EPI.cervical_suprabasal.inflammatory_repair	0.30	Nonsignificant	—	0.42	Other	0	0
437	FIB.transitioning.secretory_procollagen	0.30	Nonsignificant	—	0.00	Other	0	0
438	EPI.thymic_cortical.secretory_remodeling	0.30	Nonsignificant	—	0.00	Other	4	1
439	EPI.esophageal_suprabasal.differentiating_keratin	0.30	Nonsignificant	2.60e-03	1.92	Other	131	61
440	FIB.interstitial.remodeling	0.29	Nonsignificant	1.00	0.34	Other	31	9
441	CM.contractile_oxphos	0.29	Nonsignificant	1.00	1.08	Other	6	19
442	EC.arterial.elastic	0.28	Nonsignificant	0.65	1.04	Other	22	45
443	EPI.skin_hair_follicle_bulge.anagen_growth	0.28	Nonsignificant	—	0.00	Other	0	0
444	FIB.barrier_secretory.remodeling	0.28	Nonsignificant	—	0.00	Other	0	0
445	FIB.lung_alveolar.mito_secretory	0.28	Nonsignificant	—	0.48	Other	0	0
446	CM.inflammatory	0.27	Nonsignificant	—	1.97	Other	0	0
447	ASPC.inflammatory	0.27	Nonsignificant	0.52	1.06	Other	21	61
448	FIB.transitioning.ISG_primed_interface	0.27	Nonsignificant	—	0.00	Other	17	80
449	MAC.alveolar.capillary_interacting	0.26	Nonsignificant	0.99	0.21	Other	113	181
450	EPI.colonic_enteroendocrine.Lcell_peptide	0.26	Nonsignificant	—	0.00	Other	0	0
451	EPI.renal_principal_cell.inflammatory	0.25	Nonsignificant	0.37	1.25	Other	74	157
452	EPI.tracheal_submucosal_gland.ductal_luminal	0.24	Nonsignificant	—	0.00	Other	0	0
453	THYMO.proliferative_G2M	0.24	Nonsignificant	—	0.00	Other	164	413
454	MAC.LAM.perivascular_angiocrine	0.24	Nonsignificant	—	0.00	Other	53	138
455	ASPC.proliferative	0.23	Nonsignificant	0.52	1.07	Other	33	85
456	EPI.renal_thick_ascending_limb.salt_sensing	0.23	Nonsignificant	1.00	1.06	Other	73	103
457	EPI.ectocervical_granular.immune_interact	0.23	Nonsignificant	—	0.00	Other	0	0
458	CM.mechano_activated	0.22	Nonsignificant	1.00	1.04	Other	205	134
459	EPI.lung_club_secretory.ciliogenesis_primed	0.22	Nonsignificant	—	0.00	Other	0	0
460	IPSC.stromal_primed	0.21	Nonsignificant	1.00	0.84	Other	0	0
461	FIB.lung_alveolar.stress_interacting	0.21	Nonsignificant	—	0.00	Other	0	0
462	ASTRO.homeostatic	0.20	Nonsignificant	1.00	0.00	Other	200	431
463	EPI.skin_follicular_keratinizing.transit_amplifying	0.20	Nonsignificant	—	0.00	Other	21	49
464	MAC.LAM.anti_inflammatory	0.20	Nonsignificant	1.00	0.04	Other	86	132
465	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.19	Nonsignificant	—	0.00	Other	0	0
466	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.19	Nonsignificant	—	0.00	Other	0	0
467	EPI.colonic_tuft.homeostatic	0.19	Nonsignificant	—	0.42	Other	0	0
468	EPI.salivary_mucous_acinar.baseline	0.19	Nonsignificant	—	—	Other	394	683
469	EPI.esophageal_suprabasal.proliferative_exit	0.19	Nonsignificant	—	0.04	Other	0	0
470	ASPC.secretory	0.19	Nonsignificant	1.00	0.67	Other	76	5
471	EPI.renal_intercalated_cell_type_A.PC_transitional	0.19	Nonsignificant	—	0.84	Other	203	407
472	EPI.lung_club_secretory.canonical_surfactant	0.18	Nonsignificant	—	0.00	Other	74	104
473	MAC.kupffer.stress	0.18	Nonsignificant	0.60	0.97	Other	9	3
474	ASPC.mesothelial_like	0.17	Nonsignificant	0.52	1.12	Other	143	486
475	EC.capillary.activated	0.17	Nonsignificant	0.63	1.25	Other	2	5
476	DC.cDC1.baseline	0.16	Nonsignificant	—	0.00	Other	0	0
477	EC.capillary.stress	0.16	Nonsignificant	0.15	1.21	Other	44	36
478	EPI.renal_principal_cell.activated_acute	0.16	Nonsignificant	0.97	0.97	Other	29	59
479	NEU.EXC_NTNG1.synaptic	0.15	Nonsignificant	—	0.00	Other	0	0
480	IPSC.proliferative	0.15	Nonsignificant	1.00	0.76	Other	0	0
481	EPI.ileal_goblet.baseline	0.15	Nonsignificant	0.95	1.11	Other	16	2
482	EC.lymphatic.scavenger	0.14	Nonsignificant	1.00	0.51	Other	203	257
483	EC.arterial.ion_pump	0.14	Nonsignificant	0.27	1.18	Other	3	2
484	EPI.ileal_goblet.stress_metallothionein	0.13	Nonsignificant	—	0.00	Other	4	11
485	HPC.LMPP	0.13	Nonsignificant	1.00	0.48	Other	65	31
486	EPI.pancreatic_islet.beta	0.13	Nonsignificant	0.76	0.89	Other	42	57
487	EPI.endocervical_secretory.squamous_barrier	0.12	Nonsignificant	—	0.67	Other	0	0
488	MAC.kupffer.fibrogenic	0.11	Nonsignificant	—	0.07	Other	0	0
489	EPI.thymic_cortical.Notch_interface	0.11	Nonsignificant	—	0.52	Other	82	137
490	MESO.activated_migratory	0.11	Nonsignificant	—	0.44	Other	0	0
491	EC.arterial.inflammatory	0.11	Nonsignificant	0.98	0.98	Other	63	50
492	FIB.adventitial.PI16_matrix	0.11	Nonsignificant	1.00	0.95	Other	70	90
493	EPI.ileal_goblet.inflammatory_mucin	0.11	Nonsignificant	1.00	0.00	Other	6	9
494	EPI.thymic_cortical.baseline	0.11	Nonsignificant	0.69	0.67	Other	185	386
495	ASPC.baseline	0.10	Nonsignificant	1.00	0.10	Other	363	170
496	IPSC.canonical_pluripotent	0.10	Nonsignificant	1.00	0.72	Other	0	0
497	FIB.tracheal_subepithelial.baseline	0.09	Nonsignificant	—	0.00	Other	0	0
498	EPI.renal_principal_cell.intercalated_like	0.09	Nonsignificant	0.20	1.30	Other	63	66
499	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.08	Nonsignificant	—	0.86	Other	39	82
500	MESO.secretory_structural	0.08	Nonsignificant	—	1.08	Other	0	0
501	EPI.renal_distal_tubule.immune_modulatory	0.08	Nonsignificant	—	0.00	Other	0	0
502	EPI.colonic_tuft.activated	0.08	Nonsignificant	—	0.00	Other	0	0
503	EC.arterial.arteriole_gas_exchange	0.08	Nonsignificant	0.27	1.06	Other	238	131
504	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.08	Nonsignificant	—	0.00	Other	0	0
505	EC.arterial.mito_contact	0.08	Nonsignificant	0.98	0.95	Other	14	5
506	EPI.esophageal_suprabasal.basal_transitional	0.07	Nonsignificant	0.98	0.38	Other	44	67
507	FIB.adventitial.inflammatory_activated	0.06	Nonsignificant	1.00	1.06	Other	100	473
508	EPI.alveolar_type_1.activated	0.06	Nonsignificant	—	1.64	Other	0	0
509	FIB.adventitial.mechano_chemo_sensing	0.06	Nonsignificant	1.00	0.96	Other	135	524
510	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.05	Nonsignificant	—	1.15	Other	0	0
511	EPI.renal_immature_ureteric_bud.defense_secretory	0.05	Nonsignificant	0.77	1.10	Other	45	76
512	EPI.salivary_duct_ion_transport.baseline	0.05	Nonsignificant	—	—	Other	0	0
513	IPSC.endoderm_primed	0.05	Nonsignificant	1.00	0.74	Other	0	0
514	EPI.renal_intercalated_cell_type_A.acid_secretion	0.05	Nonsignificant	0.98	0.33	Other	12	6
515	FIB.adventitial.baseline	0.05	Nonsignificant	1.00	0.79	Other	157	278
516	EPI.ectocervical_granular.proliferative_basal	0.05	Nonsignificant	—	0.00	Other	0	0
517	EPI.renal_immature_ureteric_bud.osmoprotective	0.04	Nonsignificant	0.77	0.94	Other	126	44
518	EPI.skin_keratinocyte_basal.basement_anchoring	0.04	Nonsignificant	—	0.00	Other	0	0
519	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.04	Nonsignificant	—	0.00	Other	0	0
520	EPI.renal_principal_cell.canonical_vasopressin	0.04	Nonsignificant	0.97	0.82	Other	2	0
521	EPI.esophageal_basal.activated_progenitor	0.03	Nonsignificant	0.24	1.52	Other	1	0
522	HPC.MEP	0.03	Nonsignificant	1.00	0.22	Other	599	1,195
523	EPI.salivary_myoepithelial.contractile_repair	0.03	Nonsignificant	—	0.28	Other	3	9
524	HPC.MPP_activated	0.03	Nonsignificant	—	0.00	Other	0	0
525	MAC.kupffer.metabolic	0.03	Nonsignificant	—	0.00	Other	25	36
526	FIB.adventitial.complement_angiocrine	0.03	Nonsignificant	1.00	0.59	Other	153	684
527	EPI.salivary_myoepithelial.baseline	0.02	Nonsignificant	0.63	1.20	Other	42	141
528	EPI.renal_distal_tubule.ciliated_remodelling	0.02	Nonsignificant	—	0.00	Other	0	0
529	EPI.tracheal_basal.activated_stress	0.02	Nonsignificant	0.08	1.53	Other	32	0
530	EC.capillary.inflammatory	0.02	Nonsignificant	0.99	0.86	Other	27	51
531	ASPC.signal_integrator	0.02	Nonsignificant	—	0.00	Other	0	0
532	EPI.esophageal_basal.junctional_barrier	0.02	Nonsignificant	—	0.00	Other	0	0
533	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.02	Nonsignificant	0.02	1.39	Other	11	22
534	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.02	Nonsignificant	—	0.00	Other	0	0
535	EPI.esophageal_suprabasal.proliferative_S	0.02	Nonsignificant	—	0.00	Other	26	41
536	FIB.adventitial.mito_secretory	0.02	Nonsignificant	1.00	0.73	Other	21	7
537	EC.arterial.arteriole_interface	0.02	Nonsignificant	0.99	0.82	Other	31	12
538	GRNLSA.angiocrine_mechanosensory	0.02	Nonsignificant	—	0.00	Other	0	0
539	EC.arterial.homeostatic	0.02	Nonsignificant	0.99	0.79	Other	24	3
540	EPI.renal_thick_ascending_limb.cation_flux	0.02	Nonsignificant	1.00	0.76	Other	57	95
541	EPI.esophageal_suprabasal.proliferative_G2M	0.02	Nonsignificant	—	0.00	Other	0	0
542	ADIPO.hypoxia_remodelling	0.02	Nonsignificant	—	0.00	Other	29	105
543	EC.capillary.baseline	0.01	Nonsignificant	0.99	0.79	Other	246	560
544	EPI.pancreatic_acinar.stress	0.01	Nonsignificant	0.61	1.17	Other	28	28
545	FIB.adventitial.activated_remodelling	0.01	Nonsignificant	—	0.00	Other	141	319
546	MESO.baseline	0.01	Nonsignificant	0.83	0.65	Other	0	6
547	EC.heart_remodeling.remodeling_secretory	0.01	Nonsignificant	0.01	1.39	Other	605	1,341
548	EC.venous.adipose_lipid	0.01	Nonsignificant	0.08	1.22	Other	254	476
549	EC.capillary.angiogenic_tip	0.01	Nonsignificant	0.99	0.98	Other	186	218
550	EC.capillary.angiocrine	0.01	Nonsignificant	0.99	0.79	Other	250	630
551	MAC.kupffer.inflammatory	0.01	Nonsignificant	—	0.00	Other	7	4
552	EPI.salivary_myoepithelial.activated	0.01	Nonsignificant	0.97	0.44	Other	85	281
553	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.01	Nonsignificant	—	0.73	Other	0	0
554	HEP.periportal_metabolic.apolipoprotein_secretory	9.72e-03	Nonsignificant	0.18	1.19	Other	43	110
555	EPI.salivary_myoepithelial.junctional_transport	9.21e-03	Nonsignificant	0.97	0.46	Other	66	121
556	EPI.skin_keratinocyte_progenitor.activated_stress	7.58e-03	Nonsignificant	—	0.00	Other	0	0
557	EPI.renal_thick_ascending_limb.remodeling	7.26e-03	Nonsignificant	1.00	0.56	Other	152	92
558	MESO.activated_stress	6.90e-03	Nonsignificant	—	0.00	Other	0	0
559	EPI.renal_thick_ascending_limb.canonical_salt_transporter	6.51e-03	Nonsignificant	1.00	0.50	Other	322	317
560	EC.heart_remodeling.angiocrine	6.37e-03	Nonsignificant	0.56	1.14	Other	182	525
561	EC.capillary.migratory	6.01e-03	Nonsignificant	0.99	0.60	Other	181	509
562	HEP.acute_phase.stress_secretory	5.76e-03	Nonsignificant	0.23	1.23	Other	26	3
563	EC.heart_remodeling.capillary_metabolic	5.41e-03	Nonsignificant	0.56	1.23	Other	54	414
564	EPI.tracheal_basal.homeostatic_progenitor	5.40e-03	Nonsignificant	1.00	0.00	Other	285	74
565	CM.baseline	5.28e-03	Nonsignificant	1.00	0.95	Other	393	0
566	EPI.thymic_medullary.canonical_alarmin	5.22e-03	Nonsignificant	0.14	1.55	Other	8	17
567	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	4.62e-03	Nonsignificant	0.72	1.11	Other	7	16
568	MESO.antiviral	4.56e-03	Nonsignificant	—	0.00	Other	3	8
569	EC.venous.activated	4.50e-03	Nonsignificant	0.32	1.10	Other	247	752
570	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	4.39e-03	Nonsignificant	0.72	0.90	Other	33	34
571	EC.venous.baseline	4.39e-03	Nonsignificant	0.32	1.05	Other	346	807
572	PLAT.adhesion	4.37e-03	Nonsignificant	—	0.48	Other	0	0
573	EPI.pancreatic_acinar.baseline	4.36e-03	Nonsignificant	1.00	1.03	Other	274	163
574	EPI.thymic_medullary.stress_APC	4.28e-03	Nonsignificant	0.21	1.37	Other	2	4
575	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	4.02e-03	Nonsignificant	0.40	1.24	Other	2	9
576	EC.heart_remodeling.perivascular	3.85e-03	Nonsignificant	0.83	0.90	Other	124	408
577	HEP.acute_phase.proliferative	3.80e-03	Nonsignificant	—	0.83	Other	4	6
578	EPI.renal_principal_cell.injury_repair	3.79e-03	Nonsignificant	0.99	0.24	Other	26	9
579	EPI.salivary_intercalated_defense.inflammatory	3.48e-03	Nonsignificant	0.98	0.53	Other	152	360
580	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	3.46e-03	Nonsignificant	—	1.44	Other	0	0
581	EC.heart_remodeling.remodeling_stalk	3.39e-03	Nonsignificant	0.83	0.91	Other	33	111
582	CM.mito_proteostasis	3.20e-03	Nonsignificant	1.00	1.01	Other	329	29
583	EPI.tracheal_suprabasal.secretory_immune	3.06e-03	Nonsignificant	—	0.00	Other	0	0
584	EC.capillary.postcap_venule	3.05e-03	Nonsignificant	0.99	0.68	Other	355	261
585	EPI.renal_intercalated_cell_type_B.baseline	2.99e-03	Nonsignificant	—	0.00	Other	3	1
586	EPI.tracheal_suprabasal.transitional_wound	2.92e-03	Nonsignificant	—	0.00	Other	16	1
587	CHOND.remodeling	2.49e-03	Nonsignificant	—	0.98	Other	5	0
588	CHOND.angiogenic	2.45e-03	Nonsignificant	—	1.29	Other	0	0
589	EC.venous.cardiac_structural	2.44e-03	Nonsignificant	0.36	1.21	Other	102	229
590	EPI.thymic_medullary.hormone_xeno_barrier	1.99e-03	Nonsignificant	—	0.00	Other	0	8
591	IPSC.stress	1.94e-03	Nonsignificant	1.00	0.59	Other	0	0
592	EPI.endocervical_secretory.secretory_translocon	1.93e-03	Nonsignificant	—	0.00	Other	0	0
593	EPI.skin_sebaceous_duct_luminal.detox_repair	1.53e-03	Nonsignificant	0.82	0.75	Other	137	94
594	EPI.pancreatic_acinar.inflammatory_regenerative	1.52e-03	Nonsignificant	1.00	0.96	Other	25	113
595	IPSC.neural_primed	1.40e-03	Nonsignificant	1.00	0.63	Other	0	0
596	EPI.thymic_medullary.proliferative_APC	1.39e-03	Nonsignificant	—	0.00	Other	0	0
597	CHOND.articular_collagen	1.23e-03	Nonsignificant	0.16	1.14	Other	551	266
598	EPI.alveolar_type_1.baseline	1.16e-03	Nonsignificant	1.00	0.00	Other	8	0
599	EC.heart_remodeling.activated_acute	1.11e-03	Nonsignificant	0.83	0.70	Other	102	186
600	EC.heart_remodeling.translation_boost	1.00e-03	Nonsignificant	—	0.00	Other	0	0
601	EPI.extrahepatic_cholangiocyte.barrier_interface	9.72e-04	Nonsignificant	—	0.00	Other	0	0
602	ADIPO.immature	9.36e-04	Nonsignificant	—	0.00	Other	24	40
603	EPI.salivary_serous_acinar.seromucous_like	9.10e-04	Nonsignificant	—	1.45	Other	0	0
604	EC.venous.quiescent_homeostatic	9.07e-04	Nonsignificant	1.00	0.79	Other	456	360
605	EPI.pancreatic_ductal_bicarbonate.stress	8.98e-04	Nonsignificant	—	0.86	Other	12	33
606	HEP.acute_phase.complement_antiviral	8.95e-04	Nonsignificant	0.86	1.06	Other	377	751
607	CM.oxidative_phospho	8.63e-04	Nonsignificant	1.00	0.94	Other	266	792
608	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	8.53e-04	Nonsignificant	—	1.79	Other	0	0
609	EPI.pancreatic_ductal_perivascular.baseline	8.14e-04	Nonsignificant	0.72	1.07	Other	1	5
610	IPSC.mesenchymal_primed	7.57e-04	Nonsignificant	1.00	0.52	Other	0	0
611	EC.liver_sinusoidal.remodeling_lipotoxicity	6.82e-04	Nonsignificant	—	0.71	Other	90	58
612	EPI.pancreatic_acinar.quiet_dedifferentiation	6.59e-04	Nonsignificant	1.00	0.80	Other	142	171
613	EC.liver_sinusoidal.prostanoid	6.45e-04	Nonsignificant	—	0.49	Other	11	64
614	IPSC.neuroendocrine_primed	6.17e-04	Nonsignificant	—	0.00	Other	0	0
615	CM.osmoprotection	5.72e-04	Nonsignificant	1.00	0.94	Other	34	57
616	EPI.pancreatic_ductal_perivascular.protective_antioxidant	5.05e-04	Nonsignificant	—	0.00	Other	11	69
617	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	4.86e-04	Nonsignificant	0.66	1.19	Other	219	533
618	EPI.salivary_duct_excretory.stress	4.65e-04	Nonsignificant	0.63	1.02	Other	33	68
619	EC.arterial.angiogenic_tip	4.61e-04	Nonsignificant	—	0.00	Other	30	37
620	EPI.salivary_duct_excretory.baseline	4.57e-04	Nonsignificant	0.63	0.95	Other	23	57
621	EPI.salivary_serous_acinar.secretory_active	4.13e-04	Nonsignificant	0.58	1.01	Other	242	69
622	EPI.lung_club_secretory.inflammatory	3.97e-04	Nonsignificant	—	0.00	Other	0	0
623	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	3.86e-04	Nonsignificant	—	0.81	Other	0	0
624	CHOND.pro_inflammatory	3.82e-04	Nonsignificant	1.00	0.82	Other	181	351
625	HEP.acute_phase.inflammatory	3.21e-04	Nonsignificant	0.86	1.02	Other	382	649
626	HEP.periportal_metabolic.acute_phase_barrier	3.20e-04	Nonsignificant	0.95	1.04	Other	533	138
627	EC.liver_sinusoidal.hypoxia_metabolic	3.10e-04	Nonsignificant	0.64	0.96	Other	183	107
628	EPI.skin_appendage_keratinocyte.transit_amplifying	3.03e-04	Nonsignificant	—	0.00	Other	109	358
629	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	2.86e-04	Nonsignificant	—	0.00	Other	0	0
630	EC.liver_sinusoidal.secretory_lipoprotein	2.59e-04	Nonsignificant	0.64	0.92	Other	120	70
631	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	2.51e-04	Nonsignificant	—	0.42	Other	0	0
632	HEP.periportal_metabolic.stress_checkpoint	2.26e-04	Nonsignificant	0.95	1.04	Other	234	786
633	CM.translation_boost_RPS	2.20e-04	Nonsignificant	1.00	0.94	Other	69	16
634	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	2.16e-04	Nonsignificant	—	0.11	Other	0	0
635	EPI.salivary_intercalated_defense.basal_EMT	2.11e-04	Nonsignificant	—	0.00	Other	0	0
636	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.71e-04	Nonsignificant	—	0.00	Other	0	0
637	EPI.cervical_suprabasal.secretory_vesicle	1.58e-04	Nonsignificant	—	0.00	Other	0	0
638	CHOND.activated_fibro_like	1.57e-04	Nonsignificant	1.00	0.67	Other	531	188
639	EPI.salivary_serous_acinar.quiescent	1.35e-04	Nonsignificant	0.58	1.02	Other	178	493
640	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.25e-04	Nonsignificant	—	0.51	Other	6	9
641	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.05e-04	Nonsignificant	1.00	0.00	Other	449	1,034
642	CM.sarcomere_actin_interface	9.73e-05	Nonsignificant	1.00	0.91	Other	450	78
643	EPI.skin_sebaceous_duct_luminal.immune_interface	9.02e-05	Nonsignificant	—	0.00	Other	0	0
644	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	8.86e-05	Nonsignificant	—	0.73	Other	0	0
645	EPI.skin_keratinocyte_proliferating.detox_repair	7.80e-05	Nonsignificant	—	0.00	Other	0	0
646	EPI.pancreatic_acinar.adhesion_remodeling	6.79e-05	Nonsignificant	1.00	0.86	Other	210	784
647	IPSC.midbrain_primed	4.57e-05	Nonsignificant	1.00	0.37	Other	0	0
648	CM.translation_boost_RPL	4.46e-05	Nonsignificant	1.00	0.84	Other	129	1
649	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.49e-05	Nonsignificant	—	0.03	Other	5	3
650	EPI.pancreatic_ductal_bicarbonate.baseline	3.08e-05	Nonsignificant	0.91	0.75	Other	11	42
651	PLAT.megakaryocytic	2.90e-05	Nonsignificant	—	0.00	Other	0	0
652	EPI.pancreatic_ductal_bicarbonate.inflammatory	2.76e-05	Nonsignificant	0.66	1.22	Other	14	32
653	EC.venous.remodeling_stalk	2.59e-05	Nonsignificant	1.00	0.20	Other	559	566
654	HEP.canalicular_transport.pericentral_like_hypoxia	2.53e-05	Nonsignificant	0.39	1.14	Other	326	8
655	EPI.hepatic_ductular_cholangiocyte.stress	2.37e-05	Nonsignificant	—	1.01	Other	0	0
656	EPI.pancreatic_ductal_bicarbonate.activated	2.07e-05	Nonsignificant	0.70	0.98	Other	10	7
657	CM.anti_inflammatory	1.63e-05	Nonsignificant	1.00	0.86	Other	424	1,503
658	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.43e-05	Nonsignificant	—	0.00	Other	0	0
659	HEP.acute_phase.baseline	1.17e-05	Nonsignificant	1.00	0.70	Other	946	19
660	EC.liver_sinusoidal.inflammatory	1.03e-05	Nonsignificant	—	0.00	Other	223	154
661	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	8.54e-06	Nonsignificant	0.70	1.00	Other	40	191
662	HEP.canalicular_transport.secretory_ERAD_UPR	4.63e-06	Nonsignificant	0.39	1.16	Other	232	28
663	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.76e-06	Nonsignificant	—	0.19	Other	0	0
664	EPI.hepatic_ductular_cholangiocyte.polarity	2.15e-06	Nonsignificant	—	0.00	Other	0	0
665	HEP.periportal_metabolic.urea_onecarbon_secretory	2.02e-06	Nonsignificant	1.00	0.88	Other	1,332	3,053
666	EPI.pancreatic_ductal_progenitor.ADM_like	1.84e-06	Nonsignificant	—	0.00	Other	0	0
667	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.69e-06	Nonsignificant	—	0.00	Other	49	237
668	EPI.pancreatic_ductal_progenitor.baseline	1.67e-06	Nonsignificant	0.97	0.60	Other	179	702
669	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.60e-06	Nonsignificant	—	0.16	Other	0	0
670	EC.liver_sinusoidal.stress	1.59e-06	Nonsignificant	—	0.00	Other	413	158
671	EPI.pancreatic_acinar.metabolic_onecarbon	9.90e-07	Nonsignificant	1.00	0.38	Other	287	328
672	EPI.pancreatic_ductal_progenitor.ciliated_transport	8.55e-07	Nonsignificant	—	0.00	Other	105	368
673	HEP.canalicular_transport.inflammatory	3.64e-07	Nonsignificant	0.78	0.98	Other	1,335	194
674	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	2.97e-07	Nonsignificant	—	0.00	Other	0	0
675	HEP.periportal_metabolic.inflammatory_activated	1.66e-07	Nonsignificant	1.00	0.79	Other	712	1,610
676	HEP.canalicular_transport.ductular_like_transition	8.53e-08	Nonsignificant	0.78	0.97	Other	400	87
677	HEP.canalicular_transport.injury_stress	7.57e-08	Nonsignificant	0.79	0.90	Other	289	24
678	HEP.acute_phase.complement_metabolic	7.29e-08	Nonsignificant	1.00	0.40	Other	1,423	3,464
679	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	4.69e-08	Nonsignificant	—	0.00	Other	0	0
680	HEP.periportal_metabolic.xenobiotic_detox	1.89e-08	Nonsignificant	1.00	0.76	Other	1,440	139
681	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.26e-08	Nonsignificant	—	0.00	Other	0	0
682	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.09e-08	Nonsignificant	—	0.00	Other	0	0
683	HEP.canalicular_transport.sterol_lipid_biosynthesis	6.65e-09	Nonsignificant	—	0.19	Other	10	20
684	HEP.canalicular_transport.baseline	4.98e-09	Nonsignificant	0.78	0.95	Other	199	477
685	HEP.periportal_metabolic.stress_chaperone	3.86e-09	Nonsignificant	—	0.00	Other	66	128
686	ADIPO.inflammatory	2.23e-09	Nonsignificant	—	0.00	Other	0	0
687	HEP.periportal_metabolic.canonical_urea_cycle	3.56e-10	Nonsignificant	1.00	0.49	Other	1,464	269
688	HEP.acute_phase.hypoxia_lipid	5.63e-11	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

6 unique genes. Showing 1–6. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
GDNF-AS1	02-Medium	0.58	23.17	G1	C2	—	—	5 cells — complete matches	1	1
ADGRE3	02-Medium	0.52	7.86	G1	C2	—	DC.cDC2.monocyte_like (Tier: specific) MONO.CD14.APC_like (Tier: specific)	36 cells — complete matches	2	5
GDNF	02-Medium	0.50	14.16	G1	C2	—	—	EPI.skin_hair_follicle_bulge.anagen_growth (L2), T.CD4_Tcm.Tfh_like (L2)	6	20
ZNF333	02-Medium	0.50	8.73	G1	C2	—	B.age_associated.naive_transitional (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant)	19 cells — complete matches	2	2
SLC1A3-AS1	02-Medium	0.32	5.92	G2	C2	—	—	—	0	0
ADGRE2	02-Medium	0.23	6.86	G2	C2	MAC.resident_repair.stress_iron (L2)	DC.cDC2.monocyte_like (Tier: specific) MONO.CD14.APC_like (Tier: specific) T.CD4_Trm.metal_stress (Tier: relevant)	80 cells — complete matches	1	1

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.