Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90269727 · All tissues

Cholesterol to total lipids in very large HDL percentage (UKB data field 23630): evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Cholesterol, HDL

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	granulosa_cell	26.19	Significant	1.52e-03	1.18	Specific	293	670
2	hepatocyte	25.64	Significant	3.30e-49	1.25	Specific	1,515	3,822
3	epithelial_cell	4.21	Nominal	0.17	1.02	Other	24	47
4	muscle_stem_cell	3.97	Nominal	1.00	1.07	Other	7	27
5	endothelial_cell	3.47	Nominal	0.17	1.03	Other	373	974
6	astrocyte	2.33	Nonsignificant	1.00	0.92	Other	256	1,203
7	macrophage	2.29	Nonsignificant	1.00	0.95	Other	813	1,732
8	oligodendrocyte	1.89	Nonsignificant	1.00	0.96	Other	385	1,507
9	mesothelial_cell	1.77	Nonsignificant	1.00	0.99	Other	6	36
10	schwann_cell	1.29	Nonsignificant	1.00	0.91	Other	10	57
11	platelet	1.00	Nonsignificant	—	0.56	Other	85	104
12	adipose_stem_and_progenitor_cell	0.76	Nonsignificant	1.00	0.85	Other	327	954
13	plasma_cell	0.70	Nonsignificant	1.00	0.85	Other	17	24
14	smooth_muscle_cell	0.61	Nonsignificant	1.00	0.88	Other	27	139
15	melanocyte	0.56	Nonsignificant	1.00	0.79	Other	97	309
16	fibroblast	0.48	Nonsignificant	1.00	0.81	Other	184	826
17	granulocyte	0.36	Nonsignificant	1.00	0.83	Other	5	6
18	pericyte	0.35	Nonsignificant	1.00	0.83	Other	128	517
19	chondrocyte	0.24	Nonsignificant	1.00	0.76	Other	548	1,069
20	microglia	0.19	Nonsignificant	1.00	0.74	Other	61	129
21	dendritic_cell	0.13	Nonsignificant	1.00	0.75	Other	496	724
22	adipocyte	0.07	Nonsignificant	1.00	0.67	Other	33	111
23	monocyte	0.04	Nonsignificant	1.00	0.65	Other	2,176	3,871
24	B_cell	0.03	Nonsignificant	1.00	0.65	Other	356	694
25	T_cell	8.39e-03	Nonsignificant	1.00	0.48	Other	470	959
26	thymocyte	5.67e-03	Nonsignificant	1.00	0.65	Other	168	512
27	neuron	3.00e-03	Nonsignificant	1.00	0.57	Other	330	1,328
28	innate_lymphoid_cell_2	2.22e-03	Nonsignificant	1.00	0.53	Other	3	8
29	haematopoietic_progenitor_cell	1.41e-03	Nonsignificant	1.00	0.59	Other	262	502
30	natural_killer_cell	1.08e-03	Nonsignificant	1.00	0.52	Other	1,204	2,052
31	oligodendrocyte_precursor_cell	1.00e-03	Nonsignificant	1.00	0.45	Other	461	1,454
32	cardiomyocyte	8.28e-04	Nonsignificant	1.00	0.76	Other	533	2,045
33	induced_pluripotent_stem_cell	3.00e-04	Nonsignificant	1.00	0.45	Other	0	0
34	skeletal_muscle_cell	1.91e-05	Nonsignificant	1.00	0.35	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HEP.periportal_metabolic	26.78	Significant	4.24e-06	2.24	Specific	1,750	4,427
2	GRNLSA.granulosa_cell	26.19	Significant	—	—	—	257	0
3	HEP.canalicular_transport	25.44	Significant	0.90	0.81	Specific	1,290	3,434
4	HEP.acute_phase	24.62	Significant	0.90	0.65	Specific	1,441	3,641
5	EPI.renal_thick_ascending_limb	19.79	Significant	1.09e-10	1.45	Specific	453	1,153
6	EPI.renal_distal_tubule	19.08	Significant	0.08	1.37	Relevant	133	361
7	EPI.pancreatic_ductal_progenitor	16.68	Significant	5.39e-03	1.36	Specific	234	873
8	EPI.renal_principal_cell	16.38	Significant	4.59e-03	1.36	Specific	207	403
9	EPI.renal_immature_ureteric_bud	12.30	Significant	0.19	1.20	Relevant	217	569
10	EPI.colonic_tuft	12.24	Significant	—	1.14	Relevant	7	24
11	EPI.ileal_enterocyte_absorptive	9.84	Significant	0.08	1.23	Relevant	118	338
12	EPI.ileal_bile_transport	8.96	Significant	0.22	1.26	Relevant	61	93
13	EPI.ileal_enterocyte_crypt	7.31	Significant	0.26	1.17	Relevant	67	113
14	MAC.alveolar	7.07	Significant	2.10e-05	1.45	Specific	1,432	3,122
15	EC.capillary	6.64	Significant	5.26e-17	1.47	Specific	514	1,635
16	HEP.pericentral_lipoprotein	6.32	Significant	—	0.00	Relevant	0	0
17	MAC.kupffer	6.12	Significant	0.39	1.16	Other	189	530
18	EPI.ileal_goblet	5.26	Nominal	0.89	1.12	Other	181	432
19	EPI.pancreatic_ductal_perivascular	4.84	Nominal	1.00	0.89	Other	4	30
20	EPI.colonocyte	4.64	Nominal	0.89	1.06	Other	294	815
21	EC.venous	4.50	Nominal	3.45e-03	1.17	Other	516	1,387
22	MUSC.muscle_stem_cell	3.97	Nominal	—	—	Other	4	18
23	EPI.intrahepatic_cholangiocyte_transport	3.82	Nominal	—	0.53	Other	12	42
24	EPI.hepatic_ductular_cholangiocyte	3.73	Nominal	1.00	0.93	Other	83	243
25	MAC.LAM	3.37	Nominal	4.02e-06	1.33	Other	914	2,064
26	EPI.skin_interfollicular_spinous	3.34	Nominal	1.00	0.93	Other	260	563
27	EPI.endocervical_secretory	3.10	Nominal	—	0.25	Other	0	0
28	MAC.proliferating	3.01	Nominal	1.00	1.03	Other	87	253
29	EPI.cervical_suprabasal	2.79	Nonsignificant	—	0.42	Other	14	50
30	EPI.intrahepatic_cholangiocyte_defense	2.77	Nonsignificant	—	0.23	Other	8	13
31	EPI.salivary_duct_excretory	2.61	Nonsignificant	1.00	0.78	Other	85	180
32	EPI.extrahepatic_cholangiocyte	2.53	Nonsignificant	—	0.31	Other	37	71
33	ASTRO.astrocyte	2.33	Nonsignificant	—	—	Other	228	1,111
34	EPI.renal_intercalated_cell_type_A	2.20	Nonsignificant	1.00	0.73	Other	67	142
35	EPI.renal_proximal_tubule	2.16	Nonsignificant	1.00	0.89	Other	525	806
36	EPI.tracheal_suprabasal	2.08	Nonsignificant	1.00	0.88	Other	29	56
37	EPI.bile_duct_cholangiocyte	2.01	Nonsignificant	1.00	0.88	Other	37	60
38	EPI.renal_intercalated_cell_type_B	1.90	Nonsignificant	—	0.28	Other	6	7
39	OLG.oligodendrocyte	1.89	Nonsignificant	—	—	Other	384	1,397
40	FIB.hepatic_stellate_cell	1.88	Nonsignificant	—	1.64	Other	64	252
41	EPI.pancreatic_islet	1.82	Nonsignificant	1.00	0.76	Other	52	132
42	MESO.mesothelial_cell	1.77	Nonsignificant	—	—	Other	2	18
43	EC.liver_sinusoidal	1.76	Nonsignificant	1.00	0.63	Other	1,083	1,925
44	EPI.lung_club_secretory	1.59	Nonsignificant	1.00	0.70	Other	5	14
45	FIB.neurolectin_mucosa	1.48	Nonsignificant	2.29e-03	1.47	Other	133	394
46	EPI.salivary_intercalated_defense	1.30	Nonsignificant	1.00	0.67	Other	81	161
47	SCHWN.schwann_cell	1.29	Nonsignificant	—	—	Other	7	33
48	MAC.resident_iron	1.21	Nonsignificant	1.00	0.60	Other	16	21
49	EPI.pancreatic_acinar	1.16	Nonsignificant	1.00	0.56	Other	429	1,475
50	EPI.skin_sebaceous_duct_luminal	1.13	Nonsignificant	1.00	0.65	Other	100	249
51	FIB.suburothelial	1.07	Nonsignificant	0.05	1.33	Other	122	432
52	PLAT.platelet	1.00	Nonsignificant	—	0.00	Other	38	53
53	EPI.alveolar_type_1	0.99	Nonsignificant	1.00	0.64	Other	26	101
54	EPI.pancreatic_ductal_bicarbonate	0.91	Nonsignificant	1.00	0.51	Other	131	548
55	GRANU.neutrophil	0.90	Nonsignificant	1.90e-03	1.50	Other	1,235	2,649
56	EPI.ectocervical_granular	0.89	Nonsignificant	—	0.00	Other	11	23
57	MAC.resident_repair	0.84	Nonsignificant	1.00	0.53	Other	796	1,426
58	EPI.colonic_enteroendocrine	0.82	Nonsignificant	—	0.00	Other	1	1
59	ASPC.adipose_stem_and_progenitor_cell	0.76	Nonsignificant	—	—	Other	324	930
60	PC.IgA_muocsal	0.74	Nonsignificant	0.01	1.58	Other	18	31
61	MAC.MDM	0.72	Nonsignificant	1.00	0.53	Other	623	986
62	FIB.interstitial	0.71	Nonsignificant	6.55e-04	1.26	Other	288	940
63	EPI.alveolar_type_2	0.69	Nonsignificant	1.00	0.36	Other	813	1,853
64	FIB.perivascular_interface	0.61	Nonsignificant	0.55	1.16	Other	0	0
65	EPI.pancreatic_ductal_mucinous	0.61	Nonsignificant	1.00	0.51	Other	219	430
66	SMC.smooth_muscle_cell	0.61	Nonsignificant	—	—	Other	20	101
67	MEL.melanocyte	0.56	Nonsignificant	—	—	Other	79	242
68	EC.arterial	0.54	Nonsignificant	1.00	0.32	Other	356	885
69	EC.lymphatic	0.50	Nonsignificant	1.00	0.44	Other	630	998
70	EPI.salivary_serous_acinar	0.50	Nonsignificant	1.00	0.41	Other	233	531
71	EPI.skin_keratinocyte_progenitor	0.49	Nonsignificant	—	0.00	Other	0	3
72	FIB.barrier_purinergic	0.48	Nonsignificant	—	0.05	Other	1	3
73	DC.mig	0.44	Nonsignificant	—	1.52	Other	89	156
74	PC.IgG_systemic	0.43	Nonsignificant	1.00	0.38	Other	41	60
75	EPI.esophageal_suprabasal	0.37	Nonsignificant	1.00	0.30	Other	158	404
76	PERI.pericyte	0.35	Nonsignificant	—	—	Other	117	0
77	EPI.gastric_foveolar	0.35	Nonsignificant	—	0.00	Other	0	0
78	EPI.skin_keratinocyte_proliferating	0.35	Nonsignificant	1.00	0.44	Other	47	76
79	EPI.tracheal_submucosal_gland	0.33	Nonsignificant	—	0.00	Other	0	0
80	FIB.tracheal_subepithelial	0.32	Nonsignificant	—	0.20	Other	0	0
81	DC.cDC1	0.30	Nonsignificant	0.95	1.02	Other	55	112
82	FIB.reticular	0.28	Nonsignificant	1.00	0.71	Other	19	87
83	CHOND.chondrocyte	0.24	Nonsignificant	—	—	Other	519	730
84	FIB.adventitial	0.24	Nonsignificant	1.00	0.55	Other	268	1,447
85	EPI.lung_multiciliated	0.19	Nonsignificant	1.00	0.25	Other	16	49
86	MG.microglia	0.19	Nonsignificant	—	—	Other	49	0
87	EPI.tracheal_basal	0.17	Nonsignificant	1.00	0.25	Other	398	1,120
88	FIB.skin_tenogenic	0.14	Nonsignificant	—	0.00	Other	108	227
89	DC.cDC2	0.13	Nonsignificant	0.95	0.97	Other	1,189	1,793
90	FIB.skin_sheath	0.10	Nonsignificant	1.00	0.53	Other	49	118
91	MONO.CD16	0.09	Nonsignificant	0.48	1.04	Other	1,304	1,835
92	ADIPO.adipocyte	0.07	Nonsignificant	—	—	Other	20	62
93	FIB.skin_neurosecretory	0.07	Nonsignificant	—	0.00	Other	0	0
94	T.CD4_Trm	0.07	Nonsignificant	0.31	1.07	Other	176	363
95	FIB.lung_alveolar	0.06	Nonsignificant	—	0.00	Other	6	15
96	FIB.barrier_secretory	0.05	Nonsignificant	1.00	0.50	Other	81	228
97	B.naive	0.05	Nonsignificant	0.10	1.08	Other	307	595
98	GRANU.MAST	0.05	Nonsignificant	1.00	0.00	Other	5	6
99	EPI.salivary_duct_ion_transport	0.05	Nonsignificant	1.00	0.16	Other	5	11
100	MAC.resident_cardiac	0.05	Nonsignificant	1.00	0.06	Other	485	1,074
101	EPI.salivary_myoepithelial	0.05	Nonsignificant	1.00	0.15	Other	191	714
102	EPI.skin_sweat_duct_keratinocyte	0.04	Nonsignificant	1.00	0.63	Other	146	301
103	FIB.skin_papillary	0.04	Nonsignificant	—	0.00	Other	0	0
104	T.CD4_Tfh	0.04	Nonsignificant	1.00	1.05	Other	47	45
105	MONO.CD14	0.04	Nonsignificant	1.00	0.86	Other	2,294	4,139
106	EPI.skin_hair_follicle_bulge	0.03	Nonsignificant	1.00	0.12	Other	51	178
107	EPI.salivary_mucous_acinar	0.03	Nonsignificant	1.00	0.15	Other	639	1,189
108	EC.heart_remodeling	0.03	Nonsignificant	1.00	0.01	Other	569	1,594
109	T.MAIT	0.02	Nonsignificant	1.00	0.99	Other	469	855
110	MAC.microglia_like	0.02	Nonsignificant	1.00	0.11	Other	124	179
111	EPI.esophageal_basal	0.02	Nonsignificant	1.00	0.14	Other	4	10
112	T.CD4_Th2	0.02	Nonsignificant	—	1.52	Other	1	2
113	B.memory	0.01	Nonsignificant	0.98	0.92	Other	442	882
114	T.CD8_Trm	0.01	Nonsignificant	1.00	1.00	Other	211	346
115	T.CD8_transitional	0.01	Nonsignificant	1.00	1.02	Other	497	932
116	T.CD4_Tem	9.32e-03	Nonsignificant	1.00	1.03	Other	365	697
117	T.CD4_transitional	8.07e-03	Nonsignificant	1.00	0.95	Other	48	110
118	THYMO.thymocyte	5.67e-03	Nonsignificant	—	—	Other	163	495
119	T.CD4_Treg	5.51e-03	Nonsignificant	1.00	0.96	Other	244	511
120	NEU.EXC_IT	4.60e-03	Nonsignificant	0.64	1.09	Other	411	192
121	T.CD8_naive	3.84e-03	Nonsignificant	0.74	1.03	Other	317	708
122	T.CD4_Th17	3.77e-03	Nonsignificant	1.00	0.97	Other	421	794
123	T.CD4_Tcm	3.32e-03	Nonsignificant	1.00	1.00	Other	494	988
124	ILC2.innate_lymphoid_cell_2	2.22e-03	Nonsignificant	—	—	Other	2	0
125	NEU.EXC_CT	2.14e-03	Nonsignificant	0.64	1.14	Other	362	384
126	NEU.INH_VIP	1.99e-03	Nonsignificant	0.64	1.04	Other	241	366
127	B.age_associated	1.68e-03	Nonsignificant	0.98	0.81	Other	207	350
128	EPI.skin_follicular_keratinizing	1.57e-03	Nonsignificant	1.00	0.09	Other	30	81
129	HPC.haematopoietic_progenitor_cell	1.41e-03	Nonsignificant	—	—	Other	211	370
130	T.CD4_naive	1.11e-03	Nonsignificant	1.00	0.91	Other	399	866
131	NK.natural_killer_cell	1.08e-03	Nonsignificant	—	—	Other	1,204	2,045
132	B.germinal_center	1.05e-03	Nonsignificant	0.98	0.53	Other	233	655
133	OPC.oligodendrocyte_precursor_cell	1.00e-03	Nonsignificant	—	—	Other	413	1,269
134	FIB.transitioning	9.09e-04	Nonsignificant	1.00	0.13	Other	172	497
135	T.CD8_Tem	8.75e-04	Nonsignificant	1.00	0.80	Other	1,083	1,857
136	CM.cardiomyocyte	8.28e-04	Nonsignificant	—	—	Other	524	2,032
137	T.gamma_delta	6.98e-04	Nonsignificant	1.00	0.79	Other	588	1,078
138	EPI.skin_keratinocyte_basal	4.67e-04	Nonsignificant	—	0.00	Other	13	26
139	T.CD8_Tcm	3.58e-04	Nonsignificant	1.00	0.81	Other	460	926
140	IPSC.induced_pluripotent_stem_cell	3.00e-04	Nonsignificant	—	—	Other	0	0
141	NEU.EXC_SYT2	2.66e-04	Nonsignificant	—	0.00	Other	40	77
142	NEU.INH_LAMP5	1.20e-04	Nonsignificant	1.00	0.61	Other	263	532
143	T.CD4_cytotoxic	1.20e-04	Nonsignificant	1.00	0.66	Other	855	1,493
144	NEU.EXC_NTNG1	1.07e-04	Nonsignificant	—	0.11	Other	0	0
145	EPI.thymic_medullary	8.95e-05	Nonsignificant	1.00	0.03	Other	26	133
146	EPI.skin_appendage_keratinocyte	6.46e-05	Nonsignificant	1.00	0.04	Other	87	222
147	NEU.INH_PVALB	3.57e-05	Nonsignificant	1.00	0.43	Other	193	183
148	SKM.type_2_fast	3.05e-05	Nonsignificant	0.36	1.10	Other	972	2,639
149	EPI.skin_hair_follicle_companion	2.17e-05	Nonsignificant	—	0.00	Other	8	12
150	EPI.thymic_cortical	4.09e-06	Nonsignificant	1.00	0.07	Other	442	824
151	SKM.type_1_slow	3.74e-06	Nonsignificant	0.88	0.86	Other	923	2,478
152	DC.pDC	7.93e-07	Nonsignificant	1.00	0.06	Other	496	1,028

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	GRNLSA.proliferative_migratory	40.21	Significant	0.08	1.86	—	248	292
2	HEP.periportal_metabolic.stress_chaperone	39.42	Significant	—	1.54	Specific	66	128
3	GRNLSA.EMT_insulin_signaling	32.77	Significant	0.15	1.69	—	47	84
4	HEP.periportal_metabolic.xenobiotic_detox	31.36	Significant	1.37e-03	2.19	—	1,440	139
5	HEP.canalicular_transport.baseline	31.29	Significant	0.05	2.00	Relevant	199	477
6	HEP.periportal_metabolic.apolipoprotein_secretory	30.61	Significant	0.30	1.50	Relevant	43	110
7	HEP.periportal_metabolic.urea_onecarbon_secretory	30.00	Significant	0.12	1.60	Specific	1,332	3,053
8	GRNLSA.secretory_remodeling	29.51	Significant	0.73	1.14	—	90	25
9	HEP.acute_phase.complement_metabolic	28.64	Significant	7.47e-05	2.82	Specific	1,423	3,464
10	EPI.renal_distal_tubule.stress	28.30	Significant	—	1.16	Relevant	0	0
11	EPI.renal_thick_ascending_limb.canonical_salt_transporter	28.26	Significant	6.22e-05	2.40	—	322	317
12	HEP.canalicular_transport.inflammatory	27.75	Significant	0.01	2.12	—	1,335	194
13	HEP.periportal_metabolic.acute_phase_barrier	27.45	Significant	1.00	0.69	—	533	138
14	HEP.canalicular_transport.secretory_ERAD_UPR	26.18	Significant	0.11	1.68	—	232	28
15	HEP.acute_phase.stress_secretory	26.10	Significant	1.00	1.02	—	26	3
16	HEP.canalicular_transport.pericentral_like_hypoxia	24.50	Significant	1.00	0.58	—	326	8
17	HEP.acute_phase.baseline	24.27	Significant	1.00	0.77	—	946	19
18	HEP.periportal_metabolic.canonical_urea_cycle	24.26	Significant	1.00	0.42	—	1,464	269
19	HEP.canalicular_transport.ductular_like_transition	23.67	Significant	1.00	0.30	—	400	87
20	HEP.acute_phase.hypoxia_lipid	23.41	Significant	—	0.00	Relevant	0	0
21	EPI.renal_principal_cell.activated_acute	22.61	Significant	0.21	1.78	Relevant	29	59
22	GRNLSA.cholesterol_mevalonate	22.60	Significant	0.76	1.01	—	9	4
23	GRNLSA.p53_damage	21.97	Significant	—	0.00	—	13	10
24	HEP.periportal_metabolic.stress_checkpoint	21.95	Significant	1.00	0.66	Relevant	234	786
25	GRNLSA.stress_metabolic	21.93	Significant	—	0.00	—	1	2
26	HEP.canalicular_transport.sterol_lipid_biosynthesis	21.90	Significant	—	0.00	Relevant	10	20
27	GRNLSA.angiocrine_mechanosensory	21.63	Significant	—	0.00	—	0	0
28	EPI.renal_thick_ascending_limb.barrier_repair	21.60	Significant	0.58	1.24	Relevant	141	284
29	EPI.renal_distal_tubule.immune_modulatory	21.39	Significant	—	0.33	Relevant	0	0
30	GRNLSA.lipid_hypoxia	21.15	Significant	1.00	0.40	—	28	0
31	HEP.canalicular_transport.injury_stress	20.95	Significant	1.00	0.03	—	289	24
32	HEP.acute_phase.inflammatory	20.93	Significant	1.00	0.12	Relevant	382	649
33	HEP.acute_phase.complement_antiviral	19.81	Significant	1.00	0.08	Relevant	377	751
34	EPI.renal_principal_cell.inflammatory	19.32	Significant	0.45	1.43	Relevant	74	157
35	HEP.periportal_metabolic.inflammatory_activated	17.97	Significant	1.00	0.03	Relevant	712	1,610
36	EPI.pancreatic_ductal_progenitor.baseline	17.90	Significant	1.48e-03	2.58	Specific	179	702
37	EPI.renal_thick_ascending_limb.cation_flux	17.50	Significant	1.00	0.68	Relevant	57	95
38	EPI.pancreatic_ductal_progenitor.ciliated_transport	17.42	Significant	—	0.14	Relevant	105	368
39	EPI.renal_distal_tubule.ion_transport	17.30	Significant	—	0.13	—	0	0
40	HEP.acute_phase.proliferative	16.90	Significant	—	0.00	Relevant	4	6
41	EPI.colonic_tuft.homeostatic	16.29	Significant	—	0.42	—	0	0
42	EPI.renal_thick_ascending_limb.remodeling	15.84	Significant	1.00	0.40	—	152	92
43	EPI.renal_distal_tubule.repair	15.83	Significant	—	0.00	Relevant	34	102
44	EPI.renal_principal_cell.injury_repair	15.80	Significant	0.98	0.62	—	26	9
45	MAC.kupffer.monocyte_like	13.56	Significant	—	1.50	Relevant	0	0
46	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	13.44	Significant	—	0.00	—	0	0
47	EPI.ileal_enterocyte_absorptive.brush_border	12.88	Significant	2.63e-03	2.21	Specific	580	1,717
48	EPI.renal_principal_cell.intercalated_like	12.53	Significant	0.98	0.65	—	63	66
49	EPI.renal_immature_ureteric_bud.osmoprotective	12.44	Significant	0.47	1.10	—	126	44
50	EPI.renal_immature_ureteric_bud.defense_secretory	11.88	Significant	0.47	1.03	—	45	76
51	MAC.alveolar.scavenging_endocytic	11.70	Significant	—	1.12	Relevant	140	283
52	EPI.renal_thick_ascending_limb.salt_sensing	11.49	Significant	1.00	0.10	—	73	103
53	GRNLSA.chemokine_mechanosensory	11.19	Significant	1.00	0.00	—	1	0
54	EPI.renal_principal_cell.canonical_vasopressin	11.08	Significant	0.98	0.11	—	2	0
55	EC.capillary.postcap_venule	10.00	Significant	0.01	1.58	—	355	261
56	EC.venous.adipose_lipid	9.61	Significant	1.30e-04	1.95	Specific	254	476
57	EPI.ileal_bile_transport.detox_transcytosis	9.20	Significant	—	0.19	Relevant	0	1
58	EC.capillary.migratory	8.93	Significant	0.04	1.50	Specific	181	509
59	EPI.ileal_bile_transport.absorptive_xenobiotic	8.88	Significant	0.85	0.39	Relevant	11	12
60	EPI.pancreatic_ductal_progenitor.ADM_like	8.73	Significant	—	0.00	—	0	0
61	EPI.colonocyte.ionocyte_BEST4	8.51	Significant	3.92e-04	2.29	Specific	103	188
62	EPI.ileal_enterocyte_crypt.villus_transition	8.50	Significant	—	0.39	—	7	10
63	MAC.alveolar.biosynthetic_sterol_heme	8.45	Significant	0.72	1.23	—	347	40
64	EPI.colonic_tuft.activated	8.26	Significant	—	0.00	—	0	0
65	EPI.ileal_enterocyte_crypt.baseline	8.20	Significant	0.04	1.93	—	11	6
66	EPI.ileal_enterocyte_crypt.bile_transport	8.10	Significant	0.84	0.93	—	2	0
67	EPI.renal_intercalated_cell_type_A.PC_transitional	7.92	Significant	—	1.22	Specific	203	407
68	MAC.kupffer.stress	7.80	Significant	0.41	1.11	Relevant	9	3
69	EC.capillary.stress	7.62	Significant	0.49	1.14	Relevant	44	36
70	EPI.ileal_enterocyte_crypt.secretory_precursor	7.35	Significant	—	0.00	—	0	0
71	MAC.LAM.perivascular_angiocrine	7.28	Significant	—	1.43	Relevant	53	138
72	HEP.pericentral_lipoprotein.UPR_redox	6.89	Significant	—	0.67	—	0	0
73	EPI.ileal_enterocyte_absorptive.villus_tip	6.77	Significant	1.00	0.00	—	4	3
74	EPI.pancreatic_ductal_perivascular.protective_antioxidant	6.70	Significant	—	0.67	Relevant	11	69
75	MAC.kupffer.inflammatory	6.52	Significant	—	0.41	Relevant	7	4
76	EC.capillary.baseline	6.51	Significant	0.86	0.95	Other	246	560
77	MAC.alveolar.capillary_interacting	6.50	Significant	0.72	0.96	Relevant	113	181
78	MAC.alveolar.lipid_autophagy	6.47	Significant	—	0.03	Relevant	35	44
79	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	6.44	Significant	—	1.44	Relevant	0	0
80	EPI.ileal_enterocyte_crypt.proliferative_S	6.34	Significant	0.98	0.23	—	4	2
81	MAC.alveolar.stress_metabolic	6.24	Significant	0.72	1.11	Relevant	116	148
82	EPI.colonocyte.secretory_boost	6.22	Significant	0.23	1.51	Relevant	98	91
83	EC.capillary.angiocrine	6.09	Significant	0.92	0.85	Other	250	630
84	HEP.pericentral_lipoprotein.ApoB_coagulation	5.76	Significant	—	0.00	Relevant	0	0
85	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	5.75	Significant	—	1.15	Relevant	0	0
86	EC.capillary.angiogenic_tip	5.71	Significant	0.15	1.43	Other	186	218
87	EPI.ileal_goblet.baseline	5.69	Significant	0.24	1.67	Relevant	16	2
88	MAC.alveolar.inflammatory	5.65	Significant	0.93	0.50	Relevant	208	312
89	EPI.ileal_goblet.stress_metallothionein	5.63	Significant	—	0.22	Relevant	4	11
90	MAC.LAM.lipid_phagocytosis	5.62	Significant	0.03	1.64	Specific	369	328
91	EPI.colonocyte.goblet_interface	5.07	Nominal	—	0.23	Other	11	21
92	EPI.colonocyte.junction_remodeling	5.02	Nominal	0.42	1.26	Other	218	305
93	MAC.kupffer.fibrogenic	4.94	Nominal	—	0.22	Other	0	0
94	EC.venous.quiescent_homeostatic	4.94	Nominal	0.65	1.20	Other	456	360
95	EPI.colonocyte.distal_absorptive	4.87	Nominal	—	0.15	Other	0	0
96	EPI.skin_interfollicular_spinous.stress_UPR	4.73	Nominal	—	0.65	Other	0	0
97	EPI.ileal_goblet.inflammatory_mucin	4.71	Nominal	0.88	0.28	Other	6	9
98	EPI.skin_interfollicular_spinous.early_differentiation	4.68	Nominal	0.27	1.45	Other	89	19
99	EPI.hepatic_ductular_cholangiocyte.polarity	4.58	Nominal	—	0.62	Other	0	0
100	EPI.ileal_enterocyte_crypt.proliferative_G2M	4.56	Nominal	—	0.00	Other	19	54
101	EPI.ileal_goblet.immature	4.53	Nominal	—	0.00	Other	0	0
102	MUSC.baseline	4.53	Nominal	0.40	1.68	Other	0	0
103	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	4.46	Nominal	—	0.73	Other	0	0
104	EPI.tracheal_suprabasal.secretory_immune	4.30	Nominal	—	0.90	Other	0	0
105	EC.venous.baseline	4.27	Nominal	0.88	1.00	Other	346	807
106	EPI.endocervical_secretory.secretory_translocon	4.23	Nominal	—	0.67	Other	0	0
107	EPI.skin_interfollicular_spinous.baseline	4.12	Nominal	0.53	1.13	Other	35	3
108	EC.venous.activated	4.08	Nominal	0.88	0.95	Other	247	752
109	EC.capillary.activated	4.06	Nominal	0.86	0.91	Other	2	5
110	EC.capillary.inflammatory	4.06	Nominal	1.00	0.39	Other	27	51
111	ASTRO.homeostatic	4.03	Nominal	0.01	1.55	Other	200	431
112	MUSC.quiescent_reservoir	4.02	Nominal	0.61	1.27	Other	2	8
113	EPI.hepatic_ductular_cholangiocyte.ion_transport	3.84	Nominal	—	0.08	Other	0	0
114	MAC.LAM.antimicrobial	3.81	Nominal	0.89	0.92	Other	389	93
115	MAC.LAM.anti_inflammatory	3.80	Nominal	0.57	1.19	Other	86	132
116	EPI.colonocyte.crypt_progenitor	3.77	Nominal	0.97	0.42	Other	115	265
117	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.76	Nominal	—	0.32	Other	0	0
118	MAC.proliferating.stress	3.70	Nominal	—	0.00	Other	87	136
119	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	3.66	Nominal	—	0.00	Other	0	0
120	EPI.hepatic_ductular_cholangiocyte.secretory_transport	3.66	Nominal	—	0.00	Other	0	0
121	EPI.pancreatic_ductal_perivascular.baseline	3.66	Nominal	0.94	0.36	Other	1	5
122	OLG.reactive_repair	3.61	Nominal	2.68e-08	2.38	Other	385	385
123	MUSC.early_activation	3.56	Nominal	0.80	0.75	Other	4	32
124	EPI.pancreatic_islet.alpha	3.54	Nominal	—	0.87	Other	152	330
125	EPI.cervical_suprabasal.inflammatory_repair	3.45	Nominal	—	0.73	Other	0	0
126	MUSC.activated_migratory	3.45	Nominal	0.80	0.49	Other	6	7
127	MAC.resident_repair.lipid_phagocytic	3.42	Nominal	2.40e-03	1.85	Other	228	604
128	ASTRO.stress_mito	3.30	Nominal	0.91	1.12	Other	47	110
129	EC.venous.remodeling_stalk	3.29	Nominal	1.00	0.68	Other	559	566
130	EPI.salivary_duct_excretory.baseline	3.19	Nominal	0.07	1.79	Other	23	57
131	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.19	Nominal	—	0.00	Other	5	3
132	EPI.colonocyte.proximal_transport	3.15	Nominal	0.97	0.39	Other	24	12
133	MAC.kupffer.metabolic	3.13	Nominal	—	0.00	Other	25	36
134	EPI.pancreatic_acinar.stress	2.98	Nonsignificant	9.97e-05	2.11	Other	28	28
135	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	2.96	Nonsignificant	—	0.00	Other	6	9
136	EPI.skin_interfollicular_spinous.stress_oxidative	2.95	Nonsignificant	—	0.00	Other	0	0
137	ASTRO.hypoxia_angiogenic	2.93	Nonsignificant	0.94	0.98	Other	5	18
138	MESO.antiviral	2.83	Nonsignificant	—	0.68	Other	3	8
139	MAC.resident_iron.heme_catabolism	2.79	Nonsignificant	0.10	1.49	Other	30	51
140	EC.liver_sinusoidal.prostanoid	2.76	Nonsignificant	—	0.86	Other	11	64
141	MAC.proliferating.DNA_replication	2.69	Nonsignificant	0.66	0.84	Other	3	6
142	ASTRO.immature_lipid	2.67	Nonsignificant	0.94	0.98	Other	23	113
143	MAC.LAM.lipid_opsonization	2.63	Nonsignificant	0.89	0.83	Other	45	14
144	MAC.LAM.inflammatory_APC	2.61	Nonsignificant	1.00	0.48	Other	872	165
145	PLAT.megakaryocytic	2.61	Nonsignificant	—	0.97	Other	0	0
146	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.60	Nonsignificant	—	0.00	Other	0	0
147	EPI.skin_interfollicular_spinous.proliferative	2.60	Nonsignificant	—	0.00	Other	0	0
148	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	2.57	Nonsignificant	—	0.00	Other	0	0
149	EC.liver_sinusoidal.hypoxia_metabolic	2.54	Nonsignificant	0.07	1.60	Other	183	107
150	EPI.bile_duct_cholangiocyte.secretory_mucin	2.49	Nonsignificant	—	0.31	Other	7	12
151	MAC.resident_iron.redox_metabolic	2.49	Nonsignificant	0.40	1.24	Other	4	4
152	ASTRO.A2_reactive	2.48	Nonsignificant	0.94	0.85	Other	10	37
153	EPI.extrahepatic_cholangiocyte.barrier_interface	2.45	Nonsignificant	—	0.00	Other	0	0
154	EPI.renal_proximal_tubule.detox_antioxidant	2.36	Nonsignificant	9.59e-03	2.44	Other	394	77
155	OLG.myelinating_stress	2.34	Nonsignificant	9.11e-03	1.58	Other	232	62
156	ASTRO.stress_acute	2.32	Nonsignificant	0.04	1.52	Other	60	56
157	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	2.24	Nonsignificant	0.03	1.53	Other	219	533
158	OLG.myelinating_mature	2.24	Nonsignificant	5.42e-07	1.86	Other	363	94
159	EPI.lung_club_secretory.canonical_surfactant	2.19	Nonsignificant	—	0.61	Other	74	104
160	OLG.vesicle_trafficking	2.19	Nonsignificant	0.81	1.01	Other	124	10
161	EC.liver_sinusoidal.inflammatory	2.13	Nonsignificant	—	0.31	Other	223	154
162	EPI.cervical_suprabasal.secretory_vesicle	2.13	Nonsignificant	—	0.00	Other	0	0
163	FIB.hepatic_stellate_cell.fibrogenic	2.11	Nonsignificant	—	0.42	Other	0	0
164	MESO.secretory_structural	2.10	Nonsignificant	—	0.48	Other	0	0
165	SCHWN.reactive_inflammatory	2.10	Nonsignificant	—	0.46	Other	0	0
166	ASPC.activated	2.01	Nonsignificant	0.01	1.32	Other	164	162
167	FIB.hepatic_stellate_cell.inflammatory	1.94	Nonsignificant	—	0.32	Other	0	0
168	FIB.neurolectin_mucosa.inflammatory	1.93	Nonsignificant	0.23	1.70	Other	52	110
169	EPI.pancreatic_islet.delta	1.92	Nonsignificant	—	0.39	Other	0	0
170	EPI.lung_club_secretory.ciliogenesis_primed	1.91	Nonsignificant	—	0.79	Other	0	0
171	EPI.renal_intercalated_cell_type_B.baseline	1.90	Nonsignificant	—	0.00	Other	3	1
172	EPI.renal_proximal_tubule.onecarbon_peroxisome	1.89	Nonsignificant	1.00	0.00	Other	58	89
173	MAC.MDM.LAM_like	1.84	Nonsignificant	0.47	1.45	Other	12	14
174	MESO.activated_migratory	1.81	Nonsignificant	—	0.00	Other	0	0
175	EPI.skin_sebaceous_duct_luminal.detox_repair	1.75	Nonsignificant	0.15	1.52	Other	137	94
176	EPI.skin_interfollicular_spinous.upper_lipid	1.73	Nonsignificant	—	0.00	Other	6	6
177	EPI.ectocervical_granular.secretory_apocrine	1.72	Nonsignificant	—	1.15	Other	0	0
178	OLG.stress	1.71	Nonsignificant	1.00	0.71	Other	232	8
179	ASPC.inflammatory	1.65	Nonsignificant	0.41	1.21	Other	21	61
180	ASTRO.A1_reactive	1.65	Nonsignificant	0.94	0.89	Other	433	394
181	EPI.salivary_intercalated_defense.inflammatory	1.64	Nonsignificant	9.59e-03	2.09	Other	152	360
182	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.64	Nonsignificant	—	0.89	Other	49	237
183	ASPC.mesothelial_like	1.64	Nonsignificant	0.68	1.18	Other	143	486
184	EPI.colonic_enteroendocrine.Lcell_peptide	1.63	Nonsignificant	—	0.97	Other	0	0
185	ASTRO.synaptic_interaction	1.62	Nonsignificant	1.00	0.64	Other	76	334
186	EC.liver_sinusoidal.remodeling_lipotoxicity	1.59	Nonsignificant	—	0.13	Other	90	58
187	EPI.bile_duct_cholangiocyte.inflammatory_APC	1.56	Nonsignificant	—	0.00	Other	2	0
188	EPI.skin_interfollicular_spinous.inflammatory	1.47	Nonsignificant	—	0.00	Other	0	0
189	FIB.hepatic_stellate_cell.contractile	1.46	Nonsignificant	—	0.00	Other	0	0
190	EPI.hepatic_ductular_cholangiocyte.stress	1.43	Nonsignificant	—	0.00	Other	0	0
191	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.43	Nonsignificant	—	0.57	Other	0	0
192	EPI.renal_distal_tubule.ciliated_remodelling	1.42	Nonsignificant	—	0.00	Other	0	0
193	MESO.baseline	1.41	Nonsignificant	0.64	0.89	Other	0	6
194	FIB.neurolectin_mucosa.nerve_interface	1.41	Nonsignificant	—	0.00	Other	4	0
195	EPI.pancreatic_acinar.adhesion_remodeling	1.40	Nonsignificant	0.05	1.64	Other	210	784
196	EPI.lung_club_secretory.inflammatory	1.37	Nonsignificant	—	0.00	Other	0	0
197	EC.arterial.angiogenic_tip	1.34	Nonsignificant	—	0.70	Other	30	37
198	FIB.suburothelial.homeostasis_matrix	1.33	Nonsignificant	0.05	2.11	Other	258	921
199	FIB.neurolectin_mucosa.remodeling_repair	1.33	Nonsignificant	—	0.00	Other	4	2
200	EPI.skin_interfollicular_spinous.transition_basal	1.31	Nonsignificant	0.99	0.28	Other	100	127
201	EPI.salivary_duct_excretory.stress	1.31	Nonsignificant	0.99	0.02	Other	33	68
202	SCHWN.translation_boost	1.31	Nonsignificant	—	0.53	Other	8	1
203	EPI.ectocervical_granular.inflammatory	1.28	Nonsignificant	—	0.32	Other	0	0
204	MAC.kupffer.tolerogenic	1.25	Nonsignificant	—	0.00	Other	45	49
205	FIB.neurolectin_mucosa.axon_responsive	1.24	Nonsignificant	0.86	0.43	Other	10	10
206	ASPC.preadipocyte_lipid_primed	1.23	Nonsignificant	6.40e-03	1.24	Other	331	129
207	EPI.pancreatic_acinar.metabolic_onecarbon	1.22	Nonsignificant	0.03	1.55	Other	287	328
208	FIB.interstitial.remodeling	1.18	Nonsignificant	0.48	1.18	Other	31	9
209	FIB.interstitial.immune_interact	1.13	Nonsignificant	0.54	1.13	Other	12	1
210	FIB.suburothelial.inflammatory_prostanoid	1.13	Nonsignificant	—	0.68	Other	0	0
211	OLG.regulatory_activated	1.11	Nonsignificant	1.00	0.15	Other	196	614
212	EPI.alveolar_type_1.baseline	1.10	Nonsignificant	0.09	1.80	Other	8	0
213	FIB.suburothelial.contractile_myofibroblast	1.08	Nonsignificant	—	0.08	Other	9	0
214	EPI.alveolar_type_2.stress_response	1.06	Nonsignificant	5.91e-05	1.82	Other	675	1,562
215	EPI.salivary_intercalated_defense.canonical_antimicrobial	1.05	Nonsignificant	0.88	0.42	Other	11	22
216	EPI.ectocervical_granular.immune_interact	1.05	Nonsignificant	—	0.00	Other	0	0
217	GRANU.neutrophil.tissue_patrolling	1.01	Nonsignificant	—	1.28	Other	0	0
218	SCHWN.axon_contact_cardiac	1.01	Nonsignificant	0.96	0.04	Other	18	63
219	DC.cDC1.baseline	1.00	Nonsignificant	—	1.53	Other	0	0
220	EC.arterial.inflammatory	1.00	Nonsignificant	0.43	1.17	Other	63	50
221	EC.liver_sinusoidal.stress	0.99	Nonsignificant	—	0.00	Other	413	158
222	OLG.regulatory	0.98	Nonsignificant	1.00	0.01	Other	353	73
223	FIB.barrier_purinergic.stress_GF_binding	0.97	Nonsignificant	—	0.97	Other	0	0
224	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.96	Nonsignificant	0.99	0.87	Other	40	191
225	GRANU.neutrophil.antiviral_endotoxin	0.93	Nonsignificant	—	0.26	Other	0	0
226	MONO.CD14.inflammatory	0.92	Nonsignificant	0.08	1.32	Other	92	134
227	EPI.pancreatic_acinar.inflammatory_regenerative	0.90	Nonsignificant	0.92	0.88	Other	25	113
228	SMC.activated	0.87	Nonsignificant	0.05	1.24	Other	2	5
229	FIB.interstitial.mesenchymal_regulator	0.87	Nonsignificant	1.00	0.89	Other	4	4
230	PERI.inflammatory	0.87	Nonsignificant	0.02	1.25	Other	40	77
231	MAC.resident_iron.heme_recycling	0.86	Nonsignificant	—	0.12	Other	30	37
232	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.85	Nonsignificant	—	0.00	Other	0	0
233	FIB.suburothelial.urothelial_interface	0.84	Nonsignificant	0.94	0.29	Other	9	8
234	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.82	Nonsignificant	8.89e-03	1.99	Other	449	1,034
235	PC.IgA_muocsal.baseline	0.82	Nonsignificant	0.57	1.15	Other	3	5
236	EPI.endocervical_secretory.squamous_barrier	0.82	Nonsignificant	—	0.00	Other	0	0
237	MEL.stress_glucocorticoid	0.81	Nonsignificant	0.75	0.89	Other	11	34
238	MAC.resident_repair.ECM_stromal_crosstalk	0.81	Nonsignificant	0.81	1.14	Other	95	158
239	GRANU.neutrophil.primed_degranulation	0.78	Nonsignificant	—	0.00	Other	0	0
240	EC.lymphatic.activated	0.76	Nonsignificant	0.20	1.32	Other	47	73
241	PC.IgA_muocsal.activated	0.75	Nonsignificant	0.57	1.11	Other	17	8
242	EPI.pancreatic_acinar.quiet_dedifferentiation	0.74	Nonsignificant	1.00	0.38	Other	142	171
243	SMC.metabolic	0.74	Nonsignificant	0.05	1.23	Other	14	40
244	MAC.MDM.APC_dendritic	0.72	Nonsignificant	0.80	1.00	Other	48	15
245	FIB.perivascular_interface.vascular_BM_remodelling	0.72	Nonsignificant	—	0.73	Other	0	0
246	MEL.secretory_quiescent	0.72	Nonsignificant	0.09	1.51	Other	19	13
247	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.72	Nonsignificant	—	0.87	Other	135	290
248	PC.IgA_muocsal.migratory	0.71	Nonsignificant	0.88	0.93	Other	4	1
249	MAC.resident_repair.stress_iron	0.69	Nonsignificant	0.84	0.90	Other	48	97
250	EC.arterial.arteriole_interface	0.68	Nonsignificant	0.31	1.24	Other	31	12
251	FIB.perivascular_interface.vasomotor_tone	0.66	Nonsignificant	—	0.36	Other	0	0
252	MESO.activated_stress	0.66	Nonsignificant	—	0.00	Other	0	0
253	PC.IgG_systemic.secretory	0.65	Nonsignificant	0.03	1.64	Other	0	0
254	EC.arterial.arteriole_gas_exchange	0.63	Nonsignificant	0.43	1.09	Other	238	131
255	EC.lymphatic.tip_migratory	0.63	Nonsignificant	0.20	1.36	Other	23	37
256	EPI.salivary_serous_acinar.quiescent	0.62	Nonsignificant	0.18	1.50	Other	178	493
257	MAC.resident_repair.chemokine_angiocrine	0.62	Nonsignificant	0.84	0.87	Other	87	138
258	FIB.interstitial.mesenchymal_APC	0.61	Nonsignificant	1.00	0.95	Other	81	33
259	EPI.salivary_intercalated_defense.basal_EMT	0.61	Nonsignificant	—	0.00	Other	0	0
260	EC.arterial.metabolic	0.60	Nonsignificant	0.99	0.90	Other	195	159
261	EC.arterial.mito_contact	0.59	Nonsignificant	0.43	1.15	Other	14	5
262	EPI.tracheal_submucosal_gland.ductal_luminal	0.59	Nonsignificant	—	0.42	Other	0	0
263	EC.liver_sinusoidal.secretory_lipoprotein	0.58	Nonsignificant	1.00	0.00	Other	120	70
264	EPI.renal_intercalated_cell_type_A.acid_secretion	0.58	Nonsignificant	1.00	0.00	Other	12	6
265	EPI.skin_keratinocyte_progenitor.activated_stress	0.56	Nonsignificant	—	0.11	Other	0	0
266	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.56	Nonsignificant	0.98	0.22	Other	2	9
267	EPI.pancreatic_ductal_bicarbonate.baseline	0.56	Nonsignificant	0.99	0.52	Other	11	42
268	MAC.MDM.inflammatory_phagocytic	0.55	Nonsignificant	0.80	0.74	Other	199	52
269	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.54	Nonsignificant	—	0.00	Other	0	0
270	EPI.pancreatic_acinar.baseline	0.54	Nonsignificant	1.00	0.14	Other	274	163
271	EPI.pancreatic_ductal_bicarbonate.stress	0.53	Nonsignificant	—	0.00	Other	12	33
272	FIB.adventitial.mechano_chemo_sensing	0.53	Nonsignificant	0.05	1.35	Other	135	524
273	ASPC.baseline	0.53	Nonsignificant	1.00	0.80	Other	363	170
274	PERI.baseline	0.51	Nonsignificant	0.36	1.08	Other	39	66
275	PC.IgG_systemic.interacting	0.50	Nonsignificant	0.28	1.31	Other	0	0
276	EPI.lung_club_secretory.ciliogenesis_axoneme	0.50	Nonsignificant	—	0.00	Other	0	0
277	EPI.esophageal_suprabasal.differentiating_keratin	0.50	Nonsignificant	1.11e-03	2.03	Other	131	61
278	EPI.salivary_serous_acinar.secretory_active	0.50	Nonsignificant	0.43	1.05	Other	242	69
279	FIB.perivascular_interface.lipid_shuttle	0.49	Nonsignificant	—	0.00	Other	51	170
280	MAC.resident_iron.APC_iron_sensing	0.49	Nonsignificant	1.00	0.33	Other	211	114
281	EC.lymphatic.baseline	0.48	Nonsignificant	0.50	1.10	Other	38	72
282	EPI.tracheal_suprabasal.transitional_wound	0.47	Nonsignificant	—	0.00	Other	16	1
283	PC.IgA_muocsal.plasmablast	0.47	Nonsignificant	0.89	0.67	Other	5	4
284	ASPC.adipocyte_capillary_interface	0.47	Nonsignificant	1.00	0.67	Other	21	54
285	MAC.MDM.complement_resolving	0.46	Nonsignificant	0.80	0.88	Other	440	860
286	ASTRO.neuromodulatory	0.46	Nonsignificant	1.00	0.12	Other	34	172
287	EPI.colonic_enteroendocrine.progenitor	0.45	Nonsignificant	—	0.00	Other	0	0
288	ASPC.secretory	0.45	Nonsignificant	1.00	0.74	Other	76	5
289	DC.mig.baseline	0.44	Nonsignificant	—	0.00	Other	1	0
290	EPI.alveolar_type_2.baseline_surfactant	0.43	Nonsignificant	1.00	0.49	Other	64	9
291	PERI.angiocrine	0.42	Nonsignificant	1.00	0.90	Other	93	102
292	MAC.resident_repair.antigen_presenting	0.42	Nonsignificant	0.97	0.52	Other	244	113
293	CHOND.articular_collagen	0.42	Nonsignificant	5.94e-03	1.50	Other	551	266
294	MEL.mature_oxidative_traffic	0.40	Nonsignificant	0.75	0.81	Other	247	285
295	DC.cDC2.lipid_metabolic	0.40	Nonsignificant	—	1.04	Other	0	0
296	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.39	Nonsignificant	0.99	0.71	Other	14	32
297	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.39	Nonsignificant	—	0.00	Other	0	0
298	EPI.pancreatic_islet.beta	0.37	Nonsignificant	1.00	0.00	Other	42	57
299	EPI.skin_sweat_duct_keratinocyte.barrier	0.36	Nonsignificant	—	1.52	Other	0	0
300	EPI.alveolar_type_2.injury_primed	0.36	Nonsignificant	1.00	0.30	Other	434	245
301	EPI.gastric_foveolar.baseline	0.35	Nonsignificant	—	0.00	Other	0	0
302	PC.IgG_systemic.stress	0.33	Nonsignificant	—	0.00	Other	1	5
303	FIB.reticular.stromal_niche	0.33	Nonsignificant	0.63	0.92	Other	0	0
304	FIB.tracheal_subepithelial.baseline	0.32	Nonsignificant	—	0.00	Other	0	0
305	EPI.ectocervical_granular.proliferative_basal	0.32	Nonsignificant	—	0.00	Other	0	0
306	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.31	Nonsignificant	—	0.00	Other	0	0
307	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.31	Nonsignificant	—	0.00	Other	0	0
308	FIB.adventitial.mito_secretory	0.30	Nonsignificant	0.96	0.93	Other	21	7
309	DC.cDC2.proliferative	0.30	Nonsignificant	—	0.34	Other	39	71
310	MONO.CD14.repair_M2_like	0.30	Nonsignificant	0.06	1.21	Other	550	1,495
311	EPI.alveolar_type_1.activated	0.29	Nonsignificant	—	0.00	Other	0	0
312	ADIPO.inflammatory	0.29	Nonsignificant	—	1.59	Other	0	0
313	T.CD8_transitional.stress	0.28	Nonsignificant	—	2.02	Other	24	34
314	MEL.neurotrophic_migratory	0.28	Nonsignificant	—	0.00	Other	0	0
315	SMC.contractile	0.28	Nonsignificant	1.00	0.70	Other	80	588
316	FIB.adventitial.baseline	0.27	Nonsignificant	0.96	0.92	Other	157	278
317	T.CD4_Trm.metal_stress	0.27	Nonsignificant	0.10	1.35	Other	34	58
318	FIB.adventitial.complement_angiocrine	0.27	Nonsignificant	0.96	1.07	Other	153	684
319	FIB.reticular.ECM_builder	0.26	Nonsignificant	—	0.00	Other	0	0
320	EPI.lung_multiciliated.stress	0.26	Nonsignificant	—	0.61	Other	67	165
321	DC.cDC2.tolerogenic_regulatory	0.25	Nonsignificant	0.28	1.18	Other	44	4
322	EC.arterial.homeostatic	0.24	Nonsignificant	0.99	0.81	Other	24	3
323	FIB.reticular.stress_metallothionein	0.24	Nonsignificant	—	0.00	Other	3	32
324	MONO.CD16.platelet_bound	0.24	Nonsignificant	0.34	1.30	Other	372	508
325	FIB.reticular.immune_interface	0.23	Nonsignificant	—	0.00	Other	1	6
326	MG.baseline	0.23	Nonsignificant	0.06	1.56	Other	16	5
327	CHOND.pro_inflammatory	0.23	Nonsignificant	0.42	1.15	Other	181	351
328	DC.cDC1.homeostatic_inhibitory	0.22	Nonsignificant	—	0.20	Other	0	0
329	FIB.adventitial.adhesion_lipid	0.22	Nonsignificant	0.96	0.87	Other	58	209
330	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.22	Nonsignificant	—	0.00	Other	0	0
331	MONO.CD16.baseline	0.21	Nonsignificant	0.16	1.28	Other	50	1
332	PC.IgG_systemic.metabolic	0.21	Nonsignificant	0.99	0.15	Other	46	63
333	EPI.tracheal_basal.activated_stress	0.21	Nonsignificant	0.72	1.15	Other	32	0
334	MONO.CD16.hepatic_mac_like	0.20	Nonsignificant	0.08	1.33	Other	803	117
335	MEL.dedifferentiated_migratory	0.19	Nonsignificant	—	0.00	Other	0	0
336	B.naive.restrained	0.19	Nonsignificant	0.01	1.18	Other	183	353
337	DC.cDC1.cross_presenting	0.19	Nonsignificant	—	0.00	Other	0	0
338	EPI.pancreatic_ductal_bicarbonate.activated	0.19	Nonsignificant	0.99	0.34	Other	10	7
339	EC.lymphatic.scavenger	0.18	Nonsignificant	1.00	0.16	Other	203	257
340	FIB.adventitial.activated_remodelling	0.18	Nonsignificant	—	0.15	Other	141	319
341	EC.lymphatic.valve	0.17	Nonsignificant	—	0.00	Other	0	0
342	DC.cDC1.activated	0.17	Nonsignificant	—	0.00	Other	0	0
343	FIB.interstitial.stress_secretory	0.16	Nonsignificant	1.00	0.66	Other	92	56
344	EPI.esophageal_suprabasal.proliferative_S	0.16	Nonsignificant	—	0.00	Other	26	41
345	CHOND.angiogenic	0.15	Nonsignificant	—	0.00	Other	0	0
346	DC.cDC2.pro_inflammatory	0.15	Nonsignificant	0.88	0.96	Other	3	5
347	MG.expanding	0.15	Nonsignificant	0.82	0.82	Other	2	1
348	EPI.lung_multiciliated.baseline	0.15	Nonsignificant	—	0.00	Other	0	7
349	FIB.skin_tenogenic.baseline	0.14	Nonsignificant	—	0.00	Other	0	2
350	MG.phagocytic_APC	0.14	Nonsignificant	0.82	0.69	Other	25	8
351	EPI.tracheal_basal.homeostatic_progenitor	0.14	Nonsignificant	0.77	0.69	Other	285	74
352	EPI.esophageal_suprabasal.basal_transitional	0.14	Nonsignificant	0.98	0.18	Other	44	67
353	T.CD4_Trm.helper_like	0.14	Nonsignificant	0.42	1.17	Other	84	147
354	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.14	Nonsignificant	—	0.00	Other	0	0
355	FIB.adventitial.inflammatory_activated	0.14	Nonsignificant	0.96	0.87	Other	100	473
356	FIB.lung_alveolar.stress_interacting	0.13	Nonsignificant	—	0.97	Other	0	0
357	EC.arterial.elastic	0.12	Nonsignificant	0.99	0.62	Other	22	45
358	CHOND.activated_fibro_like	0.12	Nonsignificant	1.00	0.28	Other	531	188
359	MAC.resident_cardiac.inflammatory_reparative	0.12	Nonsignificant	0.40	1.32	Other	31	96
360	THYMO.SP_CD8_naive_stress	0.12	Nonsignificant	0.40	1.26	Other	1	1
361	MONO.CD14.platelet_bound	0.12	Nonsignificant	0.08	1.19	Other	964	176
362	FIB.skin_sheath.neuro_vascular_interface	0.12	Nonsignificant	—	0.59	Other	0	0
363	CHOND.remodeling	0.11	Nonsignificant	—	0.00	Other	5	0
364	T.MAIT.stress	0.11	Nonsignificant	—	1.46	Other	0	0
365	EC.arterial.ion_pump	0.11	Nonsignificant	0.99	0.68	Other	3	2
366	DC.cDC2.monocyte_like	0.10	Nonsignificant	0.32	1.14	Other	1,285	791
367	ADIPO.immature	0.10	Nonsignificant	—	0.61	Other	24	40
368	FIB.skin_sheath.ECM_immune	0.10	Nonsignificant	—	0.00	Other	0	0
369	MAC.resident_iron.stress_tolerogenic	0.10	Nonsignificant	—	0.00	Other	0	0
370	FIB.skin_sheath.stress_chaperone	0.10	Nonsignificant	—	0.00	Other	0	0
371	T.CD4_Trm.activated	0.09	Nonsignificant	0.72	1.08	Other	32	26
372	T.CD4_Trm.baseline	0.09	Nonsignificant	0.49	1.09	Other	31	21
373	DC.cDC2.migratory	0.09	Nonsignificant	0.28	1.18	Other	185	39
374	FIB.barrier_purinergic.lipid_secretory	0.09	Nonsignificant	—	0.00	Other	0	0
375	ASPC.niche_keeping_progenitor	0.09	Nonsignificant	1.00	0.39	Other	52	219
376	EC.heart_remodeling.activated_acute	0.09	Nonsignificant	0.29	1.36	Other	102	186
377	EPI.tracheal_submucosal_gland.acinar_serous	0.08	Nonsignificant	—	0.00	Other	0	0
378	EPI.esophageal_suprabasal.proliferative_exit	0.08	Nonsignificant	—	0.00	Other	0	0
379	PLAT.adhesion	0.07	Nonsignificant	—	0.00	Other	0	0
380	T.CD4_Tfh.precursor_migratory	0.07	Nonsignificant	0.12	1.21	Other	72	27
381	FIB.skin_neurosecretory.baseline	0.07	Nonsignificant	—	0.00	Other	0	0
382	GRANU.MAST.resting_granule	0.07	Nonsignificant	—	0.85	Other	0	0
383	EC.heart_remodeling.translation_boost	0.07	Nonsignificant	—	1.20	Other	0	0
384	ASPC.remodeling	0.07	Nonsignificant	1.00	0.31	Other	106	354
385	B.memory.preactivated	0.06	Nonsignificant	0.42	1.12	Other	173	174
386	FIB.barrier_secretory.homeostasis	0.06	Nonsignificant	—	0.00	Other	0	0
387	EPI.salivary_myoepithelial.activated	0.06	Nonsignificant	0.18	1.42	Other	85	281
388	MAC.microglia_like.patrolling_adhesive	0.06	Nonsignificant	—	1.21	Other	0	0
389	T.MAIT.migratory	0.06	Nonsignificant	0.31	1.49	Other	10	1
390	EPI.esophageal_suprabasal.proliferative_G2M	0.06	Nonsignificant	—	0.00	Other	0	0
391	T.CD8_Trm.muscosal_Tc17	0.05	Nonsignificant	0.29	1.20	Other	19	38
392	FIB.interstitial.lipid_matrix	0.05	Nonsignificant	1.00	0.14	Other	258	191
393	MONO.CD16.inflammatory	0.05	Nonsignificant	1.00	0.86	Other	1,640	168
394	ASPC.proliferative	0.05	Nonsignificant	1.00	0.36	Other	33	85
395	EPI.skin_sebaceous_duct_luminal.immune_interface	0.05	Nonsignificant	—	0.00	Other	0	0
396	EPI.skin_hair_follicle_bulge.quiescent	0.05	Nonsignificant	9.48e-04	1.47	Other	56	69
397	DC.cDC2.antiviral	0.05	Nonsignificant	1.00	0.82	Other	100	37
398	EPI.salivary_duct_ion_transport.baseline	0.05	Nonsignificant	—	—	Other	0	0
399	EPI.salivary_myoepithelial.junctional_transport	0.04	Nonsignificant	0.18	1.47	Other	66	121
400	EC.heart_remodeling.remodeling_secretory	0.04	Nonsignificant	0.21	1.29	Other	605	1,341
401	EPI.lung_multiciliated.mature_motile_cilia	0.04	Nonsignificant	—	0.00	Other	0	0
402	EC.venous.cardiac_structural	0.04	Nonsignificant	1.00	0.00	Other	102	229
403	FIB.skin_papillary.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
404	T.CD4_Trm.stress_adaptive	0.04	Nonsignificant	0.77	1.00	Other	8	22
405	B.naive.antigen_presenting_ready	0.04	Nonsignificant	1.00	1.05	Other	48	73
406	MAC.resident_cardiac.phagocytic_homeostasis	0.04	Nonsignificant	0.95	0.70	Other	564	1,221
407	EC.heart_remodeling.perivascular	0.04	Nonsignificant	0.65	1.10	Other	124	408
408	EPI.salivary_myoepithelial.baseline	0.04	Nonsignificant	0.55	0.95	Other	42	141
409	GRANU.MAST.activated_repair	0.04	Nonsignificant	—	0.00	Other	0	1
410	FIB.adventitial.PI16_matrix	0.04	Nonsignificant	1.00	0.10	Other	70	90
411	FIB.barrier_secretory.remodeling	0.04	Nonsignificant	—	0.00	Other	0	0
412	B.memory.activated	0.03	Nonsignificant	0.42	1.07	Other	105	29
413	B.naive.baseline	0.03	Nonsignificant	1.00	0.96	Other	10	13
414	EPI.salivary_mucous_acinar.baseline	0.03	Nonsignificant	—	—	Other	394	683
415	GRANU.MAST.activated_acute	0.03	Nonsignificant	—	0.00	Other	0	0
416	EC.heart_remodeling.remodeling_stalk	0.03	Nonsignificant	1.00	0.78	Other	33	111
417	MAC.resident_cardiac.antigen_presenting	0.03	Nonsignificant	0.95	0.68	Other	52	27
418	MONO.CD16.patrolling	0.03	Nonsignificant	1.00	0.48	Other	797	216
419	T.CD4_Tfh.effector_migratory	0.03	Nonsignificant	0.63	1.09	Other	122	57
420	T.CD4_Tfh.canonical_GC_helper	0.02	Nonsignificant	0.63	1.08	Other	1	2
421	MONO.CD14.cord_tolerance	0.02	Nonsignificant	1.00	0.95	Other	864	753
422	T.CD4_Treg.tissue_effector	0.02	Nonsignificant	0.32	1.17	Other	16	13
423	T.CD4_transitional.primed_helper_effector	0.02	Nonsignificant	0.04	1.25	Other	19	43
424	NEU.EXC_IT.structural	0.02	Nonsignificant	0.55	1.30	Other	171	41
425	EPI.salivary_myoepithelial.contractile_repair	0.02	Nonsignificant	—	0.00	Other	3	9
426	MONO.CD14.baseline	0.02	Nonsignificant	1.00	0.92	Other	2,268	76
427	B.naive.activated	0.02	Nonsignificant	1.00	0.94	Other	77	127
428	EPI.esophageal_basal.junctional_barrier	0.02	Nonsignificant	—	0.32	Other	0	0
429	T.CD8_naive.mito_proteostasis	0.02	Nonsignificant	0.42	1.20	Other	428	100
430	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.77	1.07	Other	28	6
431	T.CD4_Tem.long_term_memory	0.02	Nonsignificant	0.77	1.06	Other	314	587
432	T.CD4_Th2.tissue_adapted	0.02	Nonsignificant	—	0.00	Other	0	0
433	EPI.esophageal_basal.activated_progenitor	0.02	Nonsignificant	0.67	0.83	Other	1	0
434	T.CD4_Trm.cytotoxic_effector	0.02	Nonsignificant	1.00	0.59	Other	118	77
435	B.naive.proteostasis	0.02	Nonsignificant	1.00	0.95	Other	49	69
436	T.CD4_Th2.precursor	0.02	Nonsignificant	—	0.00	Other	0	0
437	T.CD4_Tcm.effector_like	0.02	Nonsignificant	0.54	1.09	Other	293	533
438	T.CD8_Trm.homeostatic	0.02	Nonsignificant	0.29	1.11	Other	42	5
439	FIB.lung_alveolar.mito_secretory	0.01	Nonsignificant	—	0.00	Other	0	0
440	EPI.skin_keratinocyte_proliferating.detox_repair	0.01	Nonsignificant	—	0.00	Other	0	0
441	T.CD8_transitional.effector_primed	0.01	Nonsignificant	0.56	1.05	Other	435	151
442	HPC.CLP_B_primed	0.01	Nonsignificant	—	1.62	Other	0	0
443	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	1.69	Other	1	9
444	NEU.INH_VIP.enkephalinergic	0.01	Nonsignificant	—	1.42	Other	0	0
445	THYMO.DP_early_stress	0.01	Nonsignificant	—	1.83	Other	0	0
446	DC.cDC1.proliferative	0.01	Nonsignificant	—	0.00	Other	0	0
447	ASPC.stem_like_progenitor	0.01	Nonsignificant	1.00	0.31	Other	300	842
448	MONO.CD14.APC_like	0.01	Nonsignificant	1.00	0.92	Other	1,686	2,493
449	T.CD4_transitional.APC_interacting	0.01	Nonsignificant	0.32	1.24	Other	10	14
450	ADIPO.thermogenic	0.01	Nonsignificant	—	0.00	Other	0	0
451	B.naive.metabolic	9.93e-03	Nonsignificant	1.00	0.77	Other	50	79
452	T.MAIT.early_activation	9.55e-03	Nonsignificant	0.97	0.75	Other	57	4
453	B.naive.receptor_recycle	9.38e-03	Nonsignificant	1.00	0.79	Other	51	0
454	T.MAIT.vesicle	9.37e-03	Nonsignificant	0.97	0.87	Other	37	65
455	T.CD8_transitional.early	8.95e-03	Nonsignificant	0.56	1.04	Other	327	55
456	T.CD4_Tcm.stress	8.37e-03	Nonsignificant	0.64	1.13	Other	5	11
457	T.MAIT.quiescent	8.34e-03	Nonsignificant	0.97	0.64	Other	100	5
458	T.CD4_Tfh.suppression_exhaustion	8.24e-03	Nonsignificant	0.66	0.90	Other	0	2
459	EPI.skin_keratinocyte_proliferating.anchor_remodel	7.95e-03	Nonsignificant	—	0.00	Other	0	0
460	EPI.skin_hair_follicle_bulge.anagen_growth	7.78e-03	Nonsignificant	—	0.00	Other	0	0
461	T.MAIT.cytotoxic	7.31e-03	Nonsignificant	0.97	0.64	Other	52	15
462	EC.heart_remodeling.angiocrine	7.16e-03	Nonsignificant	1.00	0.33	Other	182	525
463	T.CD4_Trm.central_like	6.99e-03	Nonsignificant	1.00	0.38	Other	38	31
464	T.CD8_naive.baseline	6.98e-03	Nonsignificant	0.71	1.04	Other	142	2
465	T.MAIT.MAPK_brake	6.86e-03	Nonsignificant	0.97	0.49	Other	44	66
466	T.CD4_Tcm.tissue_homing	6.67e-03	Nonsignificant	0.64	1.07	Other	78	46
467	T.CD8_Trm.inflammatory	6.48e-03	Nonsignificant	1.00	0.93	Other	124	176
468	B.naive.purinergic	6.43e-03	Nonsignificant	1.00	0.65	Other	384	820
469	NK.immature_bridge	6.33e-03	Nonsignificant	0.66	1.04	Other	117	122
470	DC.cDC2.adhesion_signaling	6.16e-03	Nonsignificant	1.00	0.46	Other	35	9
471	ILC2.migratory	6.08e-03	Nonsignificant	—	0.80	Other	0	0
472	T.CD8_naive.nfkb_related	5.74e-03	Nonsignificant	0.71	1.17	Other	1	0
473	B.memory.baseline	5.67e-03	Nonsignificant	1.00	0.73	Other	472	99
474	B.naive.remodeling	5.49e-03	Nonsignificant	1.00	0.65	Other	135	230
475	NK.cytokine_repair_primed	5.21e-03	Nonsignificant	0.02	1.15	Other	266	11
476	T.CD4_transitional.tissue_enagement	5.20e-03	Nonsignificant	0.93	1.00	Other	5	11
477	T.CD4_Th17.migratory	5.14e-03	Nonsignificant	0.36	1.12	Other	13	23
478	PERI.cardiac_skeletal	4.93e-03	Nonsignificant	1.00	0.01	Other	313	630
479	T.CD4_naive.homeostatic	4.82e-03	Nonsignificant	0.96	1.07	Other	215	108
480	THYMO.DN_preTCR	4.80e-03	Nonsignificant	0.63	1.09	Other	41	71
481	T.CD4_transitional.baseline	4.58e-03	Nonsignificant	0.96	0.89	Other	59	97
482	T.CD4_Tcm.baseline	4.50e-03	Nonsignificant	0.54	1.08	Other	61	31
483	NEU.EXC_CT.remodeling	4.26e-03	Nonsignificant	—	0.71	Other	23	1
484	IPSC.stress	4.22e-03	Nonsignificant	0.01	1.16	Other	0	0
485	T.CD4_Treg.central_naive_like	3.91e-03	Nonsignificant	0.32	1.09	Other	333	45
486	EC.heart_remodeling.capillary_metabolic	3.85e-03	Nonsignificant	1.00	0.33	Other	54	414
487	MONO.CD14.remodeling	3.79e-03	Nonsignificant	1.00	0.66	Other	2,373	295
488	NK.adaptive_classII_inhibitory	3.71e-03	Nonsignificant	0.22	1.08	Other	880	154
489	B.age_associated.migratory	3.59e-03	Nonsignificant	0.11	1.26	Other	2	2
490	T.CD4_Th17.baseline	3.52e-03	Nonsignificant	0.77	0.97	Other	51	5
491	T.CD4_Tcm.migratory_cilium	3.48e-03	Nonsignificant	0.54	1.12	Other	5	10
492	B.germinal_center.LZ_selection	3.14e-03	Nonsignificant	—	1.13	Other	0	0
493	HPC.LMPP	3.09e-03	Nonsignificant	0.96	1.12	Other	65	31
494	B.memory.migratory	3.04e-03	Nonsignificant	1.00	0.78	Other	123	208
495	T.CD4_Th17.cytotoxic	2.98e-03	Nonsignificant	0.77	0.94	Other	332	123
496	T.CD4_Tcm.secretory	2.48e-03	Nonsignificant	0.54	1.14	Other	20	11
497	EPI.skin_follicular_keratinizing.transit_amplifying	2.45e-03	Nonsignificant	—	0.44	Other	21	49
498	ASPC.signal_integrator	2.40e-03	Nonsignificant	—	0.00	Other	0	0
499	FIB.transitioning.matrix_stress	2.38e-03	Nonsignificant	—	0.00	Other	47	138
500	NEU.EXC_CT.projector	2.38e-03	Nonsignificant	0.41	1.06	Other	87	26
501	T.CD8_naive.cytokine_dampened	2.38e-03	Nonsignificant	0.71	1.04	Other	71	4
502	T.CD4_Treg.APC_interactive	2.32e-03	Nonsignificant	0.99	0.73	Other	118	28
503	MAC.microglia_like.inflammatory_chemokine	2.19e-03	Nonsignificant	—	0.00	Other	20	32
504	NEU.INH_VIP.develop_niche	2.18e-03	Nonsignificant	—	0.95	Other	0	0
505	CM.baseline	2.17e-03	Nonsignificant	0.99	1.03	Other	393	0
506	OPC.homeostatic	2.06e-03	Nonsignificant	9.49e-03	1.31	Other	394	160
507	T.CD4_Tcm.DC_interact	1.93e-03	Nonsignificant	0.54	1.08	Other	72	32
508	T.CD4_transitional.primed_cytotoxic	1.58e-03	Nonsignificant	0.96	0.66	Other	28	30
509	EPI.skin_keratinocyte_basal.spinous_transition	1.52e-03	Nonsignificant	—	0.97	Other	0	0
510	THYMO.SP_CD8_transitional	1.49e-03	Nonsignificant	0.63	1.13	Other	32	75
511	CM.contractile_oxphos	1.35e-03	Nonsignificant	0.99	1.10	Other	6	19
512	T.CD4_Tcm.Th2_like	1.34e-03	Nonsignificant	0.76	1.07	Other	23	55
513	B.memory.pDC_imprint	1.30e-03	Nonsignificant	1.00	0.68	Other	157	103
514	T.CD8_Tem.signaling_turnover	1.26e-03	Nonsignificant	0.66	1.11	Other	425	683
515	NEU.INH_VIP.nuclear_reg	1.26e-03	Nonsignificant	—	0.48	Other	20	4
516	T.CD8_Tem.baseline	1.17e-03	Nonsignificant	0.66	1.05	Other	458	356
517	EPI.skin_follicular_keratinizing.upper_infundibulum	1.12e-03	Nonsignificant	—	0.00	Other	8	2
518	EPI.skin_follicular_keratinizing.root_infundibulum	1.09e-03	Nonsignificant	—	0.00	Other	0	0
519	T.CD8_Tem.TEMRA	1.06e-03	Nonsignificant	0.66	1.05	Other	920	1,088
520	T.gamma_delta.cytotoxic_effector	1.05e-03	Nonsignificant	0.44	1.19	Other	349	109
521	IPSC.neuroendocrine_primed	1.02e-03	Nonsignificant	—	1.88	Other	0	0
522	T.CD4_Tcm.Tfh_like	9.85e-04	Nonsignificant	0.74	1.04	Other	102	214
523	T.CD8_Tcm.effector_bias	9.23e-04	Nonsignificant	0.49	1.11	Other	199	329
524	T.CD4_Treg.Tr1_like	8.89e-04	Nonsignificant	—	0.00	Other	8	8
525	ILC2.activated	8.87e-04	Nonsignificant	—	0.00	Other	0	0
526	T.CD8_Trm.cytotoxic	8.85e-04	Nonsignificant	1.00	0.64	Other	165	85
527	T.CD8_Tem.stress_adapted	8.52e-04	Nonsignificant	0.89	0.99	Other	607	520
528	NK.adaptive_immature_precursor	8.18e-04	Nonsignificant	0.99	0.95	Other	358	111
529	B.germinal_center.LZ_memory_precursor	8.17e-04	Nonsignificant	—	0.37	Other	0	0
530	T.CD8_naive.vesicle_secretory	8.10e-04	Nonsignificant	0.71	1.10	Other	42	0
531	T.gamma_delta.early_effector	7.92e-04	Nonsignificant	0.80	1.00	Other	89	0
532	THYMO.DP_early	7.66e-04	Nonsignificant	0.72	1.01	Other	326	313
533	NK.adaptive_HLAE_tuned	7.44e-04	Nonsignificant	0.02	1.09	Other	1,124	189
534	NEU.INH_VIP.matrix	7.34e-04	Nonsignificant	—	0.32	Other	24	77
535	T.CD4_naive.mature	7.30e-04	Nonsignificant	1.00	1.01	Other	211	100
536	T.CD8_transitional.Trm_primed	7.20e-04	Nonsignificant	1.00	0.85	Other	108	15
537	THYMO.SP_CD4_naive	7.11e-04	Nonsignificant	0.63	1.13	Other	65	75
538	NEU.INH_VIP.serotonergic	7.06e-04	Nonsignificant	—	0.00	Other	9	2
539	T.CD8_transitional.APC_like	6.90e-04	Nonsignificant	1.00	0.74	Other	205	62
540	NK.adaptive_terminal_cytotoxic	6.70e-04	Nonsignificant	0.99	0.95	Other	485	802
541	IPSC.axial_identity_primed	6.50e-04	Nonsignificant	0.96	1.06	Other	0	0
542	NK.cytokine_tissue_resident	6.34e-04	Nonsignificant	0.89	1.05	Other	74	82
543	EPI.skin_hair_follicle_bulge.niche_crosstalk	6.06e-04	Nonsignificant	—	0.00	Other	29	88
544	T.CD4_naive.mature_mitoprot	5.74e-04	Nonsignificant	1.00	1.00	Other	212	476
545	NK.cytokine_lung_immediate_early	5.64e-04	Nonsignificant	0.77	1.07	Other	424	274
546	FIB.transitioning.motility_remodelling	5.29e-04	Nonsignificant	—	0.00	Other	0	0
547	NEU.EXC_IT.guidance	5.13e-04	Nonsignificant	0.97	1.06	Other	274	63
548	NEU.INH_VIP.excitatory_coupled	4.59e-04	Nonsignificant	—	0.07	Other	13	0
549	T.CD8_Tcm.helper_like	4.53e-04	Nonsignificant	0.64	1.03	Other	81	159
550	OPC.proliferative_immune_interact	4.52e-04	Nonsignificant	0.96	0.84	Other	180	373
551	T.CD4_Tcm.retro_ZNF117	4.52e-04	Nonsignificant	0.64	1.11	Other	5	9
552	MAC.microglia_like.phagocytic_redox	4.48e-04	Nonsignificant	—	0.00	Other	0	0
553	NEU.EXC_SYT2.synaptic	4.31e-04	Nonsignificant	—	0.48	Other	0	0
554	HPC.GMP_granulocytic	4.31e-04	Nonsignificant	—	0.46	Other	3	3
555	IPSC.endoderm_primed	4.26e-04	Nonsignificant	0.96	1.12	Other	0	0
556	NEU.INH_VIP.regulatory_remodeling	4.23e-04	Nonsignificant	—	0.00	Other	6	1
557	NK.cytokine_axis_baseline	3.99e-04	Nonsignificant	0.76	1.01	Other	1,172	116
558	NK.adaptive_axis_baseline	3.93e-04	Nonsignificant	0.04	1.09	Other	1,008	153
559	T.CD8_naive.splicing_enriched	3.91e-04	Nonsignificant	0.89	0.98	Other	120	16
560	IPSC.mesendo_primed	3.69e-04	Nonsignificant	0.96	1.01	Other	0	0
561	T.CD4_Tcm.imprinted_splicing	3.55e-04	Nonsignificant	0.83	1.02	Other	6	17
562	T.CD8_Trm.dendritic_recruiter	3.40e-04	Nonsignificant	1.00	0.54	Other	47	85
563	T.CD8_Tem.early_helper_like	3.38e-04	Nonsignificant	1.00	0.82	Other	445	755
564	T.CD8_naive.effector_transition	3.02e-04	Nonsignificant	0.85	1.00	Other	35	62
565	OPC.premyelinating	2.72e-04	Nonsignificant	0.96	0.64	Other	185	12
566	HPC.MPP_IEG	2.72e-04	Nonsignificant	0.96	1.00	Other	45	46
567	B.age_associated.naive_transitional	2.66e-04	Nonsignificant	—	1.11e-16	Other	0	0
568	NEU.EXC_IT.adhesion	2.62e-04	Nonsignificant	0.99	0.83	Other	252	108
569	T.gamma_delta.central_memory	2.58e-04	Nonsignificant	0.99	0.54	Other	460	919
570	IPSC.neural_primed	2.50e-04	Nonsignificant	0.96	1.03	Other	0	0
571	NEU.EXC_CT.Ca2_signaling	2.46e-04	Nonsignificant	—	0.00	Other	68	17
572	NK.adaptive_adipose_stress	2.46e-04	Nonsignificant	0.99	0.94	Other	374	39
573	T.CD4_cytotoxic.terminal_effector	2.27e-04	Nonsignificant	0.13	1.22	Other	286	21
574	EPI.thymic_medullary.canonical_alarmin	2.16e-04	Nonsignificant	0.19	1.27	Other	8	17
575	B.germinal_center.LZ_survival	2.13e-04	Nonsignificant	—	0.00	Other	0	0
576	NEU.INH_LAMP5.exc_inh_balance	1.89e-04	Nonsignificant	—	0.54	Other	46	2
577	ADIPO.hypoxia_remodelling	1.84e-04	Nonsignificant	—	0.00	Other	29	105
578	EPI.skin_appendage_keratinocyte.transit_amplifying	1.82e-04	Nonsignificant	—	0.00	Other	109	358
579	T.CD4_Tem.cytotoxic_effector	1.80e-04	Nonsignificant	0.98	0.77	Other	225	398
580	FIB.transitioning.ISG_primed_interface	1.75e-04	Nonsignificant	—	0.02	Other	17	80
581	NK.cytokine_quiescent	1.74e-04	Nonsignificant	0.76	1.03	Other	623	1,062
582	T.CD4_Tem.transitional_CM	1.73e-04	Nonsignificant	0.98	0.84	Other	31	20
583	T.CD4_naive.neddylation_mitoprot	1.56e-04	Nonsignificant	1.00	0.94	Other	93	56
584	FIB.transitioning.secretory_procollagen	1.53e-04	Nonsignificant	—	0.35	Other	0	0
585	B.germinal_center.DZ_M_phase	1.52e-04	Nonsignificant	—	0.00	Other	0	0
586	T.CD4_naive.neddylation	1.51e-04	Nonsignificant	1.00	0.97	Other	104	222
587	NEU.EXC_IT.transitional	1.47e-04	Nonsignificant	0.99	0.83	Other	237	142
588	NEU.EXC_NTNG1.synaptic	1.41e-04	Nonsignificant	—	0.67	Other	0	0
589	NEU.INH_LAMP5.rosehip	1.38e-04	Nonsignificant	—	0.00	Other	0	0
590	NEU.INH_PVALB.metabotropic	1.34e-04	Nonsignificant	—	1.10	Other	0	0
591	T.CD8_Tcm.NK_like	1.29e-04	Nonsignificant	0.64	1.04	Other	334	581
592	NEU.EXC_IT.neuromodulated	1.25e-04	Nonsignificant	0.99	0.75	Other	176	116
593	T.CD4_cytotoxic.baseline	1.21e-04	Nonsignificant	0.69	1.19	Other	0	0
594	NK.cytokine_biosynthetic_primed	1.19e-04	Nonsignificant	0.99	0.99	Other	360	21
595	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.16e-04	Nonsignificant	—	0.55	Other	43	26
596	NEU.INH_VIP.cannabinoid	1.16e-04	Nonsignificant	—	0.00	Other	0	0
597	CM.inflammatory	1.15e-04	Nonsignificant	—	1.60	Other	0	0
598	EPI.skin_sweat_duct_keratinocyte.repair	1.13e-04	Nonsignificant	—	0.20	Other	0	0
599	EPI.salivary_serous_acinar.seromucous_like	1.07e-04	Nonsignificant	—	0.00	Other	0	0
600	IPSC.mesodermal_primed	1.02e-04	Nonsignificant	0.96	0.98	Other	0	0
601	B.germinal_center.DZ_S_phase	1.01e-04	Nonsignificant	—	0.00	Other	0	0
602	NEU.INH_VIP.canonical_disinhibitory	9.11e-05	Nonsignificant	0.99	0.25	Other	59	38
603	T.CD4_naive.survival_mitoprot	9.08e-05	Nonsignificant	1.00	1.00	Other	13	7
604	T.CD8_Tcm.gut_homing	9.06e-05	Nonsignificant	0.44	1.16	Other	380	112
605	B.age_associated.activated	8.99e-05	Nonsignificant	—	0.00	Other	18	22
606	T.CD4_naive.survival	8.25e-05	Nonsignificant	1.00	0.99	Other	12	17
607	T.CD8_Tem.motility_primed	7.96e-05	Nonsignificant	1.00	0.49	Other	269	4
608	THYMO.SP_CD8_naive	7.72e-05	Nonsignificant	1.00	0.57	Other	297	177
609	NEU.INH_VIP.opioid	7.70e-05	Nonsignificant	—	0.00	Other	50	9
610	NEU.EXC_NTNG1.nuclear_reg	7.64e-05	Nonsignificant	—	0.00	Other	0	0
611	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	7.43e-05	Nonsignificant	0.73	1.19	Other	7	16
612	NEU.INH_PVALB.chandelier	7.38e-05	Nonsignificant	0.52	1.21	Other	19	16
613	NEU.EXC_IT.callosal	7.11e-05	Nonsignificant	0.99	0.57	Other	286	119
614	NEU.INH_LAMP5.projecting	6.99e-05	Nonsignificant	—	0.26	Other	0	0
615	T.CD4_Tcm.crosstalk_myeloid	6.75e-05	Nonsignificant	0.83	0.95	Other	5	4
616	T.CD4_Tcm.regulatory_poised	6.35e-05	Nonsignificant	0.83	0.96	Other	2	3
617	CM.osmoprotection	5.81e-05	Nonsignificant	0.99	1.05	Other	34	57
618	T.CD4_naive.survival_neddylation	5.50e-05	Nonsignificant	1.00	0.93	Other	26	38
619	IPSC.canonical_pluripotent	5.29e-05	Nonsignificant	0.96	0.93	Other	0	0
620	EPI.skin_hair_follicle_companion.activated_migratory	4.69e-05	Nonsignificant	—	0.97	Other	0	0
621	THYMO.proliferative_G2M	4.54e-05	Nonsignificant	—	0.00	Other	164	413
622	THYMO.CD8aa_IELp	4.36e-05	Nonsignificant	—	0.18	Other	1	7
623	SKM.type_2_fast.oxidative_IIa	4.32e-05	Nonsignificant	0.03	1.10	Other	946	56
624	T.CD4_cytotoxic.activated	4.19e-05	Nonsignificant	0.81	0.85	Other	3	1
625	T.CD4_naive.resist_bystander	4.08e-05	Nonsignificant	1.00	0.97	Other	40	25
626	T.CD4_naive.Treg_like	3.94e-05	Nonsignificant	1.00	1.05	Other	121	72
627	EPI.thymic_medullary.proliferative_APC	3.83e-05	Nonsignificant	—	0.93	Other	0	0
628	ILC2.quiescent	3.77e-05	Nonsignificant	—	0.00	Other	0	0
629	IPSC.stromal_primed	3.52e-05	Nonsignificant	0.96	0.92	Other	0	0
630	T.CD4_naive.gut_prone	3.50e-05	Nonsignificant	1.00	0.98	Other	35	70
631	T.CD4_cytotoxic.precursor	3.28e-05	Nonsignificant	0.81	0.86	Other	156	67
632	T.CD4_Tcm.APC_mimicry	3.24e-05	Nonsignificant	0.93	0.87	Other	54	43
633	T.CD4_naive.proteostasis_mitoprot	2.86e-05	Nonsignificant	1.00	0.94	Other	15	37
634	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	2.86e-05	Nonsignificant	0.73	0.81	Other	33	34
635	CM.mechano_activated	2.85e-05	Nonsignificant	0.99	1.04	Other	205	134
636	THYMO.proliferative_S	2.45e-05	Nonsignificant	1.00	0.55	Other	163	418
637	IPSC.midbrain_primed	2.41e-05	Nonsignificant	0.96	0.90	Other	0	0
638	T.CD4_cytotoxic.NK_adapted	2.37e-05	Nonsignificant	0.81	0.82	Other	82	33
639	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	2.01e-05	Nonsignificant	—	0.00	Other	0	0
640	EPI.skin_keratinocyte_basal.transit_amplifying	1.88e-05	Nonsignificant	—	0.00	Other	0	0
641	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.59e-05	Nonsignificant	—	0.00	Other	39	82
642	EPI.thymic_cortical.secretory_remodeling	1.54e-05	Nonsignificant	—	0.93	Other	4	1
643	HPC.GMP_inflammatory	1.53e-05	Nonsignificant	0.96	0.61	Other	20	10
644	NK.cytokine_vascular_patrolling	1.38e-05	Nonsignificant	1.00	0.78	Other	863	94
645	HPC.MEP	1.26e-05	Nonsignificant	0.96	0.74	Other	599	1,195
646	T.CD4_Tcm.RNA_control	1.26e-05	Nonsignificant	0.99	0.71	Other	96	4
647	T.CD8_naive.lipid_synthesis	1.21e-05	Nonsignificant	0.85	0.99	Other	6	4
648	IPSC.mesenchymal_primed	1.21e-05	Nonsignificant	0.96	0.95	Other	0	0
649	T.CD4_naive.proteostasis	1.18e-05	Nonsignificant	1.00	0.83	Other	14	9
650	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.17e-05	Nonsignificant	—	0.00	Other	0	0
651	SKM.type_1_slow.glycolytic	1.07e-05	Nonsignificant	0.20	1.23	Other	362	647
652	NEU.INH_PVALB.nuclear_reg	1.06e-05	Nonsignificant	0.80	0.76	Other	25	12
653	T.CD8_naive.innate_like	9.31e-06	Nonsignificant	0.93	0.60	Other	10	1
654	NEU.INH_PVALB.neuromodulatory	9.16e-06	Nonsignificant	—	0.00	Other	0	0
655	SKM.type_2_fast.glycolytic_IIx_IIb	9.09e-06	Nonsignificant	0.41	1.06	Other	565	1,482
656	NEU.INH_LAMP5.glial_interface	8.73e-06	Nonsignificant	—	0.00	Other	0	0
657	CM.oxidative_phospho	7.87e-06	Nonsignificant	1.00	0.99	Other	266	792
658	T.CD4_naive.purinergic	7.57e-06	Nonsignificant	1.00	0.73	Other	49	1
659	NK.adaptive_biosynthetic_primed	7.24e-06	Nonsignificant	0.99	0.79	Other	244	405
660	T.CD4_Tcm.synapse_dynamics	6.33e-06	Nonsignificant	0.99	0.76	Other	15	10
661	NEU.INH_PVALB.fastspike	5.56e-06	Nonsignificant	—	0.00	Other	24	22
662	NK.cytokine_tissue_activation	5.02e-06	Nonsignificant	0.99	0.76	Other	267	450
663	EPI.thymic_medullary.stress_APC	4.70e-06	Nonsignificant	0.88	0.63	Other	2	4
664	CM.sarcomere_actin_interface	4.63e-06	Nonsignificant	1.00	0.96	Other	450	78
665	NEU.INH_PVALB.serotonergic	2.27e-06	Nonsignificant	—	0.00	Other	0	0
666	SKM.type_1_slow.contractile	2.22e-06	Nonsignificant	0.95	0.85	Other	596	8
667	NEU.EXC_CT.Ca2_sensor	1.78e-06	Nonsignificant	—	0.00	Other	0	0
668	HPC.MPP_activated	1.56e-06	Nonsignificant	—	0.00	Other	0	0
669	CM.mito_proteostasis	1.54e-06	Nonsignificant	1.00	0.95	Other	329	29
670	DC.pDC.baseline	1.46e-06	Nonsignificant	0.43	1.27	Other	88	123
671	T.CD8_Tcm.baseline	1.37e-06	Nonsignificant	1.00	0.47	Other	90	89
672	SKM.type_1_slow.oxidative	1.09e-06	Nonsignificant	0.95	0.71	Other	802	251
673	NEU.EXC_SYT2.nuclear_reg	1.02e-06	Nonsignificant	—	0.00	Other	0	0
674	DC.pDC.immature_metabolic	6.45e-07	Nonsignificant	0.64	1.12	Other	78	124
675	EPI.thymic_medullary.hormone_xeno_barrier	3.94e-07	Nonsignificant	—	0.00	Other	0	8
676	T.CD4_naive.activated_stress	3.05e-07	Nonsignificant	1.00	0.29	Other	339	429
677	EPI.skin_hair_follicle_companion.gap_junction_contractile	2.14e-07	Nonsignificant	—	0.00	Other	0	0
678	DC.pDC.poised_migratory	2.11e-07	Nonsignificant	0.70	0.85	Other	54	95
679	IPSC.proliferative	2.04e-07	Nonsignificant	1.00	0.69	Other	0	0
680	EPI.skin_keratinocyte_basal.basement_anchoring	2.03e-07	Nonsignificant	—	0.00	Other	0	0
681	EPI.skin_sweat_duct_keratinocyte.proliferative_S	7.90e-08	Nonsignificant	—	0.00	Other	0	0
682	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	7.18e-08	Nonsignificant	—	0.00	Other	0	0
683	CM.translation_boost_RPS	6.90e-08	Nonsignificant	1.00	0.94	Other	69	16
684	CM.translation_boost_RPL	6.19e-08	Nonsignificant	1.00	0.92	Other	129	1
685	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	9.82e-09	Nonsignificant	—	0.00	Other	0	0
686	EPI.thymic_cortical.baseline	1.74e-09	Nonsignificant	0.80	0.68	Other	185	386
687	CM.anti_inflammatory	1.32e-09	Nonsignificant	1.00	0.74	Other	424	1,503
688	EPI.thymic_cortical.Notch_interface	9.20e-10	Nonsignificant	—	0.00	Other	82	137

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

330 unique genes. Showing 1–330. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
LIPC	01-High	0.79	40.60	G1	C1	—	EPI.pancreatic_ductal_progenitor (Tier: specific) EPI.pancreatic_ductal_progenitor.baseline (Tier: specific) EPI.pancreatic_ductal_progenitor.ciliated_transport (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant)	37 cells — complete matches	144	1,089
APOC4	01-High	0.71	21.02	G1	C1	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	10 cells — complete matches	242	1,341
CEACAM16-AS1	01-High	0.68	24.59	G1	C1	—	—	—	100	849
APOC2	01-High	0.68	18.78	G1	C1	MAC.MDM.LAM_like (L2)	HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) MAC.alveolar (Tier: specific) EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) EPI.ileal_bile_transport (Tier: relevant) EPI.ileal_enterocyte_absorptive (Tier: relevant) EPI.ileal_enterocyte_crypt (Tier: relevant) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.ileal_bile_transport.absorptive_xenobiotic (Tier: relevant) EPI.ileal_bile_transport.detox_transcytosis (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	93 cells — complete matches	203	1,252
ALDH1A2	01-High	0.68	48.07	G1	C1	EPI.ectocervical_granular.secretory_apocrine (L2), MAC.LAM.anti_inflammatory (L2)	EPI.renal_thick_ascending_limb (Tier: specific) EPI.renal_immature_ureteric_bud (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant)	50 cells — complete matches	72	576
APOC1P1	01-High	0.65	9.30	G1	C1	—	—	—	317	1,464
APOC1P1.2	01-High	0.65	9.30	G1	C1	—	—	—	317	1,464
NECTIN2	01-High	0.64	14.77	G1	C1	—	—	17 cells — complete matches	217	1,214
APOA5	01-High	0.62	13.00	G1	C1	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	10 cells — complete matches	143	1,150
ENSG00000280087	01-High	0.61	14.47	G1	C1	—	—	—	359	1,576
ANGPTL8	01-High	0.61	7.74	G1	C1	—	HEP.canalicular_transport (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EC.capillary.stress (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant)	14 cells — complete matches	80	654
PVR	01-High	0.60	16.93	G1	C1	—	—	26 cells — complete matches	79	711
CFB	01-High	0.60	1.33	G1	C1	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2), MAC.LAM.lipid_opsonization (L2), MAC.alveolar.scavenging_endocytic (L2), MAC.resident_repair.ECM_stromal_crosstalk (L2)	EPI.renal_principal_cell (Tier: specific) HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) MAC.alveolar (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) EPI.ileal_enterocyte_crypt (Tier: relevant) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant)	94 cells — complete matches	508	1,239
ENSG00000306519	01-High	0.60	7.60	G1	C1	—	—	—	35	101
PON3	01-High	0.60	7.49	G1	C1	—	EPI.renal_principal_cell (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) EPI.renal_intercalated_cell_type_A.PC_transitional (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) EPI.renal_principal_cell.activated_acute (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant)	34 cells — complete matches	35	101
TOMM40	01-High	0.60	16.41	G1	C1	—	—	DC.cDC2.monocyte_like (L2), EPI.ileal_goblet.immature (L2)	296	1,418
ENSG00000267282	01-High	0.60	16.99	G1	C1	—	—	—	213	1,188
ENSG00000304613	01-High	0.60	23.94	G1	C1	—	—	—	64	429
ASGR1	01-High	0.59	12.91	G1	C1	hepatocyte (L1), EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2)	hepatocyte (Tier: specific) HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) HEP.periportal_metabolic (Tier: specific) EC.capillary.migratory (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant)	43 cells — complete matches	184	416
ENSG00000287242	01-High	0.59	15.03	G1	C1	—	—	—	35	250
SCARB1	01-High	0.59	14.75	G1	C1	EC.liver_sinusoidal.hypoxia_metabolic (L2), EPI.skin_appendage_keratinocyte.sebaceous_apocrine (L2)	granulosa_cell (Tier: specific) EC.capillary.migratory (Tier: specific) EC.venous.adipose_lipid (Tier: specific)	38 cells — complete matches	52	304
CLPTM1	01-High	0.58	20.74	G1	C1	—	—	T.CD4_naive.activated_stress (L2)	254	1,362
MT1M	01-High	0.57	5.35	G1	C1	ASPC.inflammatory (L2), FIB.adventitial.activated_remodelling (L2), FIB.reticular.stress_metallothionein (L2), FIB.suburothelial.inflammatory_prostanoid (L2), MEL.stress_glucocorticoid (L2), MUSC.early_activation (L2)	EC.capillary (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) EPI.ileal_enterocyte_crypt (Tier: relevant) EC.capillary.stress (Tier: relevant) EPI.colonocyte.secretory_boost (Tier: relevant) EPI.ileal_goblet.stress_metallothionein (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	82 cells — complete matches	29	70
ENSG00000302518	01-High	0.57	16.65	G1	C1	—	—	—	121	890
ENSG00000233942	01-High	0.57	10.41	G1	C1	—	—	—	36	88
APOC1	01-High	0.57	15.06	G1	C1	ASPC.adipocyte_capillary_interface (L2), ASPC.remodeling (L2), DC.cDC2.lipid_metabolic (L2), EPI.ectocervical_granular.secretory_apocrine (L2), FIB.reticular.stromal_niche (L2), MAC.MDM.LAM_like (L2), MONO.CD16.hepatic_mac_like (L2)	granulosa_cell (Tier: specific) MAC.alveolar (Tier: specific) EPI.renal_intercalated_cell_type_A.PC_transitional (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	135 cells — complete matches	301	1,434
BCAM	01-High	0.57	17.10	G1	C1	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), NEU.EXC_IT.neuromodulated (L2)	EC.capillary (Tier: specific) EPI.renal_thick_ascending_limb (Tier: specific) EC.venous.adipose_lipid (Tier: specific) EPI.colonic_tuft (Tier: relevant) EPI.renal_distal_tubule (Tier: relevant) EPI.renal_immature_ureteric_bud (Tier: relevant) EC.capillary.stress (Tier: relevant) EPI.renal_distal_tubule.immune_modulatory (Tier: relevant) EPI.renal_distal_tubule.repair (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant) EPI.renal_thick_ascending_limb.cation_flux (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	82 cells — complete matches	119	896
APOE	01-High	0.57	13.38	G1	C1	macrophage (L1), HEP.pericentral_lipoprotein (L1S), MAC.LAM (L1S), MAC.microglia_like (L1S), ASPC.adipocyte_capillary_interface (L2), EPI.ectocervical_granular.secretory_apocrine (L2), EPI.renal_intercalated_cell_type_A.acid_secretion (L2), EPI.skin_appendage_keratinocyte.sebaceous_apocrine (L2), EPI.skin_hair_follicle_bulge.niche_crosstalk (L2), EPI.skin_keratinocyte_progenitor.quiescent_stem_like (L2), EPI.skin_keratinocyte_proliferating.early_spinous_transition (L2), FIB.interstitial.lipid_matrix (L2), FIB.perivascular_interface.lipid_shuttle (L2), FIB.suburothelial.homeostasis_matrix (L2), FIB.transitioning.ISG_primed_interface (L2), HEP.acute_phase.stress_secretory (L2), HEP.periportal_metabolic.apolipoprotein_secretory (L2), MAC.LAM.inflammatory_APC (L2), MAC.MDM.LAM_like (L2), MAC.resident_repair.lipid_phagocytic (L2), MG.phagocytic_APC (L2), NEU.INH_LAMP5.glial_interface (L2)	granulosa_cell (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	163 cells — complete matches	351	1,543
HNF1A	01-High	0.57	11.09	G1	C1	—	—	—	170	486
ENSG00000259476	01-High	0.56	18.81	G1	C1	—	—	—	58	306
ENSG00000310339	01-High	0.55	23.72	G1	C1	—	—	—	58	447
PON1	01-High	0.55	8.95	G1	C1	—	HEP.periportal_metabolic (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	14 cells — complete matches	37	159
ENSG00000285128	01-High	0.55	17.78	G1	C1	—	—	—	86	636
ZFAND2A	01-High	0.54	10.36	G1	C1	EPI.pancreatic_acinar.stress (L2), EPI.pancreatic_ductal_bicarbonate.stress (L2), EPI.renal_distal_tubule.stress (L2), IPSC.stress (L2), PERI.inflammatory (L2), T.CD4_Trm.metal_stress (L2), T.CD8_transitional.stress (L2), THYMO.SP_CD8_naive_stress (L2)	EPI.renal_distal_tubule.stress (Tier: relevant)	19 cells — complete matches	63	324
DOCK7	01-High	0.54	18.47	G1	C1	—	—	10 cells — complete matches	80	799
CTSA	01-High	0.53	17.50	G1	C1	T.CD4_transitional.tissue_enagement (L2)	EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant)	7 cells — complete matches	40	187
ENSG00000294609	01-High	0.52	16.13	G1	C1	—	—	—	50	300
ENSG00000288773	01-High	0.52	16.39	G1	C1	—	—	—	81	522
DOCK7-DT	01-High	0.51	13.56	G1	C1	—	—	—	78	794
HNF1A-AS1	01-High	0.51	12.03	G1	C1	—	—	—	191	580
ENSG00000296673	01-High	0.51	15.37	G1	C1	—	—	—	44	361
AQP9	01-High	0.51	15.28	G1	C1	EPI.endocervical_secretory.squamous_barrier (L2), MAC.alveolar.inflammatory (L2)	MAC.alveolar (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant)	55 cells — complete matches	44	363
ENSG00000277229	01-High	0.50	26.59	G1	C1	—	—	—	74	612
ADAM10	01-High	0.50	9.35	G1	C1	THYMO.DP_early (L2)	—	7 cells — complete matches	39	231
APOC4-APOC2	01-High	0.50	14.59	G1	C1	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	10 cells — complete matches	211	1,246
ENSG00000289948	01-High	0.50	15.30	G1	C1	—	—	—	46	360
ENSG00000296637	01-High	0.50	15.30	G1	C1	—	—	—	46	360
DOCK6	01-High	0.50	4.91	G1	C1	—	EC.capillary (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific)	25 cells — complete matches	106	1,012
ENSG00000302981	01-High	0.49	10.14	G1	C1	—	—	—	43	267
SMUG1P1	01-High	0.49	17.23	G1	C1	—	—	—	58	405
ALDH1A2-AS1	01-High	0.49	8.53	G1	C1	—	—	—	41	308
CEACAM19	01-High	0.48	20.73	G1	C1	—	EPI.colonocyte.secretory_boost (Tier: relevant)	22 cells — complete matches	81	710
APOA2	01-High	0.48	6.64	G1	C1	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2)	hepatocyte (Tier: specific) HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) HEP.periportal_metabolic (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.kupffer.monocyte_like (Tier: relevant) MAC.kupffer.stress (Tier: relevant)	42 cells — complete matches	27	179
ENSG00000301546	01-High	0.46	2.32	G1	C1	—	—	—	25	144
MIR5188	01-High	0.46	2.13	G1	C1	—	—	—	25	144
CEACAM22P.2	01-High	0.46	9.73	G1	C1	—	—	—	77	699
ENSG00000279095	01-High	0.45	16.74	G1	C1	—	—	—	77	701
IGSF23	01-High	0.45	12.70	G1	C1	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) EPI.ileal_enterocyte_absorptive (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	10 cells — complete matches	77	688
ZPR1	01-High	0.45	9.84	G1	C1	—	—	4 cells — complete matches	144	1,122
POLR2M	01-High	0.45	6.22	G1	C1	—	—	4 cells — complete matches	43	323
ENSG00000267114	01-High	0.45	9.30	G1	C1	—	—	—	160	1,070
DHX37	01-High	0.44	10.42	G1	C1	—	—	20 cells — complete matches	38	224
ENSG00000299894	01-High	0.43	4.81	G1	C1	—	—	—	37	230
PON2	01-High	0.43	7.94	G1	C1	—	—	18 cells — complete matches	31	72
NCOR2	01-High	0.42	5.85	G1	C1	—	—	9 cells — complete matches	55	273
CGNL1	01-High	0.40	3.13	G1	C1	—	EPI.colonic_tuft (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant)	38 cells — complete matches	53	325
UBC	01-High	0.38	2.32	G1	C1	ASTRO.stress_acute (L2), EC.liver_sinusoidal.remodeling_lipotoxicity (L2), EPI.hepatic_ductular_cholangiocyte.stress (L2), EPI.pancreatic_acinar.stress (L2), EPI.renal_distal_tubule.stress (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), EPI.tracheal_basal.homeostatic_progenitor (L2), FIB.skin_sheath.stress_chaperone (L2), MAC.kupffer.stress (L2)	HEP.periportal_metabolic.stress_chaperone (Tier: specific) EC.capillary.stress (Tier: relevant)	27 cells — complete matches	23	137
MYO5B	01-High	0.38	12.27	G1	C1	—	EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant)	38 cells — complete matches	14	15
ENSG00000301157	01-High	0.37	1.81	G1	C1	—	—	—	22	136
BRI3BP	01-High	0.37	3.84	G1	C1	—	—	18 cells — complete matches	22	136
ENSG00000293207	01-High	0.36	3.02	G1	C1	—	—	—	22	136
RPL22P19	01-High	0.36	3.02	G1	C1	—	—	—	22	136
AACS	01-High	0.36	4.29	G1	C1	—	—	19 cells — complete matches	22	136
ASB4	01-High	0.36	7.13	G1	C1	—	—	skeletal_muscle_cell (L1), EPI.pancreatic_islet (L1S), EPI.pancreatic_islet.delta (L2)	30	71
ENSG00000277022	02-Medium	0.55	8.27	G1	C2	—	—	—	30	89
CETP	02-Medium	0.53	18.45	G1	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2)	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EC.capillary.stress (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	39 cells — complete matches	47	124
MMP9	02-Medium	0.53	15.11	G1	C2	—	EC.capillary (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) MAC.LAM.perivascular_angiocrine (Tier: relevant)	57 cells — complete matches	54	374
NLRC5	02-Medium	0.52	14.99	G1	C2	—	—	42 cells — complete matches	54	163
PLTP	02-Medium	0.52	18.49	G1	C2	MAC.MDM.complement_resolving (L2), MAC.resident_cardiac.phagocytic_homeostasis (L2)	—	71 cells — complete matches	18	36
ENSG00000301874	02-Medium	0.52	9.69	G1	C2	—	—	—	7	30
BCL3	02-Medium	0.52	14.43	G2	C1	EC.arterial.inflammatory (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), HEP.pericentral_lipoprotein.UPR_redox (L2), MUSC.early_activation (L2), T.CD4_Tcm.regulatory_poised (L2)	—	14 cells — complete matches	73	301
TOP1MT	02-Medium	0.51	3.09	G1	C2	—	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant)	16 cells — complete matches	34	84
LIPC-AS1	02-Medium	0.50	22.61	G2	C1	—	—	—	53	279
ENSG00000304588	02-Medium	0.49	20.83	G2	C1	—	—	—	37	157
CYP2W1	02-Medium	0.49	13.68	G1	C2	—	EPI.ileal_enterocyte_crypt (Tier: relevant) EPI.colonocyte.secretory_boost (Tier: relevant)	23 cells — complete matches	8	49
MIR6891	02-Medium	0.48	4.75	G1	C2	—	—	—	474	812
HLA-B	02-Medium	0.48	4.35	G1	C2	EC.heart_remodeling.remodeling_stalk (L2), EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), FIB.skin_sheath.ECM_immune (L2), OPC.proliferative_immune_interact (L2), SMC.metabolic (L2)	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EC.venous.adipose_lipid (Tier: specific) EC.capillary.stress (Tier: relevant) EPI.ileal_goblet.baseline (Tier: relevant) EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant)	130 cells — complete matches	493	836
ENSG00000310291	02-Medium	0.47	13.69	G1	C2	—	—	—	16	58
ENSG00000308961	02-Medium	0.47	12.51	G1	C2	—	—	—	4	11
FCER1G	02-Medium	0.47	7.75	G1	C2	granulocyte (L1), NK.cytokine_axis_baseline (L2), NK.cytokine_biosynthetic_primed (L2), NK.cytokine_repair_primed (L2), NK.cytokine_tissue_activation (L2), NK.cytokine_tissue_resident (L2), NK.cytokine_vascular_patrolling (L2)	MAC.alveolar (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	130 cells — complete matches	104	220
MIR3936HG	02-Medium	0.46	3.37	G1	C2	—	—	—	302	416
BUD13-DT	02-Medium	0.46	14.72	G1	C2	—	—	—	105	913
GPIHBP1	02-Medium	0.46	5.42	G1	C2	—	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EC.venous.adipose_lipid (Tier: specific) EC.capillary.stress (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	39 cells — complete matches	2	2
ENSG00000283782	02-Medium	0.46	4.64	G1	C2	—	—	—	374	500
GPER1	02-Medium	0.45	12.42	G1	C2	—	—	25 cells — complete matches	25	92
IRF1	02-Medium	0.45	3.93	G1	C2	EC.arterial.inflammatory (L2), EPI.renal_principal_cell.activated_acute (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), FIB.hepatic_stellate_cell.inflammatory (L2), FIB.interstitial.immune_interact (L2), FIB.neurolectin_mucosa.inflammatory (L2), HEP.acute_phase.inflammatory (L2), PC.IgA_muocsal.plasmablast (L2)	EPI.renal_distal_tubule.stress (Tier: relevant) EPI.renal_principal_cell.activated_acute (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant)	25 cells — complete matches	618	847
SNX21	02-Medium	0.45	14.81	G1	C2	—	—	15 cells — complete matches	10	26
TNNC2	02-Medium	0.45	12.74	G1	C2	SKM.type_1_slow.glycolytic (L2)	—	6 cells — complete matches	10	26
BUD13	02-Medium	0.45	11.23	G1	C2	—	—	7 cells — complete matches	107	917
SLC22A4	02-Medium	0.45	2.47	G1	C2	—	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant)	31 cells — complete matches	289	399
ZNF696	02-Medium	0.45	2.51	G1	C2	—	—	25 cells — complete matches	27	74
CBLC	02-Medium	0.44	16.91	G2	C1	—	—	5 cells — complete matches	64	316
NEURL2	02-Medium	0.44	15.07	G1	C2	—	—	18 cells — complete matches	8	24
ENSG00000285647	02-Medium	0.44	4.66	G1	C2	—	—	—	364	611
ENSG00000271581	02-Medium	0.44	4.53	G1	C2	—	—	—	348	596
ENSG00000302100	02-Medium	0.44	7.34	G1	C2	—	—	—	59	217
GSEC	02-Medium	0.44	6.22	G1	C2	—	granulosa_cell (Tier: specific)	48 cells — complete matches	16	15
C7orf50	02-Medium	0.43	13.32	G2	C2	—	—	B.age_associated.naive_transitional (L2), B.naive.baseline (L2), T.CD4_Tcm.imprinted_splicing (L2)	14	70
SLC22A5	02-Medium	0.43	3.93	G1	C2	—	—	13 cells — complete matches	376	507
ENSG00000272172	02-Medium	0.43	2.78	G1	C2	—	—	—	27	70
GEMIN7-AS1	02-Medium	0.43	6.35	G1	C2	—	—	—	1	2
CEACAM16	02-Medium	0.43	16.00	G2	C1	—	—	—	54	258
ST3GAL4	02-Medium	0.43	5.61	G1	C2	—	granulosa_cell (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific)	38 cells — complete matches	37	47
ACOT8	02-Medium	0.43	14.16	G1	C2	—	—	6 cells — complete matches	9	25
SAPCD1-AS1	02-Medium	0.43	1.75	G1	C2	—	MAC.LAM.perivascular_angiocrine (Tier: relevant)	MAC.LAM.perivascular_angiocrine (L2)	27	56
LIPG	02-Medium	0.43	21.42	G2	C1	HEP.acute_phase.baseline (L2)	HEP.acute_phase (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) EPI.colonic_tuft (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (Tier: relevant) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant)	38 cells — complete matches	52	274
APOA1-AS	02-Medium	0.43	13.32	G1	C2	—	EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) EPI.ileal_enterocyte_absorptive (Tier: relevant) HEP.pericentral_lipoprotein (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	11 cells — complete matches	84	833
ENSG00000234378	02-Medium	0.43	5.27	G1	C2	—	—	—	43	174
DCPS	02-Medium	0.42	5.97	G2	C2	—	—	T.CD4_Tfh.canonical_GC_helper (L2)	9	7
RHPN1	02-Medium	0.42	2.50	G1	C2	—	—	44 cells — complete matches	30	73
ENSG00000271984	02-Medium	0.42	12.62	G1	C2	—	—	—	3	9
ENSG00000285796	02-Medium	0.42	17.06	G2	C2	—	—	—	8	24
MICA	02-Medium	0.42	2.94	G1	C2	—	—	7 cells — complete matches	277	593
ENSG00000288587	02-Medium	0.42	2.85	G1	C2	—	—	—	257	555
APOA1	02-Medium	0.42	10.74	G1	C2	hepatocyte (L1), EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2), EPI.ileal_bile_transport.absorptive_xenobiotic (L2), EPI.ileal_enterocyte_crypt.villus_transition (L2), HEP.acute_phase.stress_secretory (L2), HEP.periportal_metabolic.apolipoprotein_secretory (L2)	granulosa_cell (Tier: specific) HEP.canalicular_transport (Tier: specific) EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EPI.ileal_bile_transport (Tier: relevant) EPI.ileal_enterocyte_absorptive (Tier: relevant) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.ileal_bile_transport.absorptive_xenobiotic (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.kupffer.monocyte_like (Tier: relevant) MAC.kupffer.stress (Tier: relevant)	55 cells — complete matches	122	1,071
HCP5	02-Medium	0.42	5.04	G1	C2	—	—	—	510	867
RHPN1-AS1	02-Medium	0.41	2.49	G1	C2	—	EPI.colonic_tuft (Tier: relevant)	9 cells — complete matches	29	73
CARINH	02-Medium	0.41	4.53	G1	C2	—	—	—	411	545
MINCR	02-Medium	0.41	2.72	G1	C2	—	—	B.naive.baseline (L2), EC.lymphatic.valve (L2), T.CD4_Tcm.imprinted_splicing (L2)	26	69
ENSG00000225146	02-Medium	0.41	13.14	G2	C2	—	—	—	16	63
ENSG00000264668	02-Medium	0.41	3.70	G1	C2	—	—	—	27	69
NCK1-DT	02-Medium	0.41	1.04	G1	C2	—	—	—	37	84
NCK1	02-Medium	0.41	1.30	G1	C2	—	—	B.age_associated.naive_transitional (L2), T.CD4_Trm.stress_adaptive (L2)	35	67
DNTTIP1	02-Medium	0.41	12.67	G2	C2	—	—	DC.cDC2.monocyte_like (L2), EC.arterial.angiogenic_tip (L2), T.CD4_Tcm.crosstalk_myeloid (L2)	32	97
ENSG00000308823	02-Medium	0.41	14.38	G1	C2	—	—	—	105	913
ADAP1	02-Medium	0.41	12.39	G2	C1	—	MAC.LAM.perivascular_angiocrine (Tier: relevant)	35 cells — complete matches	16	48
PCIF1	02-Medium	0.41	17.30	G1	C2	—	—	T.CD8_Tcm.gut_homing (L2)	8	24
ENSG00000233902	02-Medium	0.41	3.23	G1	C2	—	—	—	150	247
ENSG00000306233	02-Medium	0.40	16.93	G1	C2	—	—	—	8	24
ANGPTL3	02-Medium	0.40	11.79	G2	C1	HEP.acute_phase.complement_metabolic (L2)	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.pericentral_lipoprotein (Tier: relevant) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	16 cells — complete matches	1	0
ZSWIM3	02-Medium	0.40	10.76	G1	C2	—	—	33 cells — complete matches	9	25
MCCD1	02-Medium	0.40	4.16	G2	C2	—	—	—	35	113
PPP1R9A	02-Medium	0.40	8.27	G2	C1	—	—	36 cells — complete matches	15	21
SIK3	02-Medium	0.40	7.69	G1	C2	OLG.regulatory (L2)	—	18 cells — complete matches	71	412
ENSG00000298170	02-Medium	0.40	4.53	G1	C2	—	—	—	353	447
NR1I3	02-Medium	0.40	4.04	G2	C1	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant)	16 cells — complete matches	11	16
WFDC3	02-Medium	0.40	11.45	G2	C2	—	—	19 cells — complete matches	34	101
PPP1R9A-AS1	02-Medium	0.40	7.00	G2	C1	—	—	—	4	6
LINC02863	02-Medium	0.40	4.38	G1	C2	—	—	—	360	492
ZNF227	02-Medium	0.40	4.16	G1	C2	—	—	14 cells — complete matches	1	1
USP1	02-Medium	0.39	9.30	G1	C2	THYMO.proliferative_S (L2)	—	EC.venous.remodeling_stalk (L2)	3	21
MICA-AS1	02-Medium	0.39	4.07	G1	C2	—	—	—	210	470
ZSWIM1	02-Medium	0.39	12.81	G1	C2	—	—	20 cells — complete matches	9	25
UBE2C	02-Medium	0.39	12.45	G1	C2	EPI.skin_keratinocyte_proliferating (L1S), ASPC.proliferative (L2), B.germinal_center.DZ_M_phase (L2), DC.cDC1.proliferative (L2), EPI.esophageal_suprabasal.proliferative_G2M (L2), EPI.ileal_enterocyte_crypt.proliferative_G2M (L2), EPI.ileal_goblet.immature (L2), EPI.skin_sweat_duct_keratinocyte.proliferative_G2M (L2)	EPI.ileal_enterocyte_crypt (Tier: relevant) EPI.colonocyte.secretory_boost (Tier: relevant)	61 cells — complete matches	9	25
NFKBIL1	02-Medium	0.39	5.71	G2	C2	—	—	4 cells — complete matches	101	243
ENSG00000257607	02-Medium	0.39	12.64	G1	C2	—	—	—	17	64
RPL7A	02-Medium	0.39	0.94	G1	C2	—	EC.venous.adipose_lipid (Tier: specific) EPI.pancreatic_ductal_progenitor.baseline (Tier: specific) EPI.colonocyte.secretory_boost (Tier: relevant) EPI.pancreatic_ductal_progenitor.ciliated_transport (Tier: relevant)	40 cells — complete matches	107	152
SNORD24	02-Medium	0.39	0.94	G1	C2	—	—	—	106	151
TOMM40L	02-Medium	0.38	5.90	G2	C2	—	—	24 cells — complete matches	11	16
ZNF335	02-Medium	0.38	15.62	G1	C2	—	EPI.colonocyte.ionocyte_BEST4 (Tier: specific)	21 cells — complete matches	8	24
LPL	02-Medium	0.38	2.70	G1	C2	adipocyte (L1), ADIPO.adipocyte (L1S)	granulosa_cell (Tier: specific) EC.capillary (Tier: specific) MAC.alveolar (Tier: specific) EC.capillary.migratory (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.LAM.perivascular_angiocrine (Tier: relevant)	79 cells — complete matches	50	219
ENSG00000226291	02-Medium	0.38	10.40	G1	C2	—	—	—	5	41
SLC12A5	02-Medium	0.38	13.90	G2	C2	—	EC.capillary (Tier: specific) EC.capillary.stress (Tier: relevant)	56 cells — complete matches	15	97
C12orf43	02-Medium	0.38	12.42	G2	C2	—	—	6 cells — complete matches	90	178
ENSG00000279103	02-Medium	0.38	4.16	G1	C2	—	—	—	1	2
APOC3	02-Medium	0.38	11.65	G1	C2	EPI.ileal_bile_transport.absorptive_xenobiotic (L2), EPI.ileal_enterocyte_crypt.villus_transition (L2), HEP.acute_phase.stress_secretory (L2), HEP.periportal_metabolic.apolipoprotein_secretory (L2)	EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EPI.ileal_bile_transport (Tier: relevant) EPI.ileal_enterocyte_absorptive (Tier: relevant) EPI.ileal_enterocyte_crypt (Tier: relevant) HEP.pericentral_lipoprotein (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.ileal_bile_transport.absorptive_xenobiotic (Tier: relevant) HEP.pericentral_lipoprotein.ApoB_coagulation (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.kupffer.monocyte_like (Tier: relevant) MAC.kupffer.stress (Tier: relevant)	42 cells — complete matches	140	1,060
PDK4-AS1	02-Medium	0.38	3.53	G2	C1	—	—	—	4	4
ENSG00000306520	02-Medium	0.38	15.51	G2	C1	—	—	—	1	0
TRIB1AL	02-Medium	0.37	5.28	G2	C1	—	—	—	87	466
DYNC1I1	02-Medium	0.37	3.18	G2	C1	—	EC.capillary (Tier: specific)	25 cells — complete matches	4	3
CASD1	02-Medium	0.37	5.16	G2	C1	B.germinal_center.LZ_survival (L2)	—	19 cells — complete matches	11	13
PCP4L1	02-Medium	0.37	4.53	G2	C2	—	—	49 cells — complete matches	11	16
ZNF233	02-Medium	0.37	4.52	G1	C2	—	—	11 cells — complete matches	1	1
ENSG00000297070	02-Medium	0.37	4.69	G1	C2	—	—	—	59	220
SDC1	02-Medium	0.37	4.69	G1	C2	plasma_cell (L1), PC.IgA_muocsal (L1S), PC.IgG_systemic (L1S), EPI.skin_hair_follicle_companion.gap_junction_contractile (L2), PC.IgG_systemic.metabolic (L2)	EPI.renal_thick_ascending_limb (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant)	34 cells — complete matches	59	220
APOA4	02-Medium	0.37	11.94	G1	C2	EPI.ileal_enterocyte_absorptive (L1S), EPI.ileal_bile_transport.absorptive_xenobiotic (L2), EPI.ileal_enterocyte_crypt.villus_transition (L2)	EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) EPI.ileal_bile_transport (Tier: relevant) EPI.ileal_enterocyte_absorptive (Tier: relevant) EPI.ileal_enterocyte_crypt (Tier: relevant) EPI.ileal_bile_transport.absorptive_xenobiotic (Tier: relevant)	11 cells — complete matches	4	30
SLC12A5-AS1	02-Medium	0.36	12.70	G2	C2	—	EC.capillary.stress (Tier: relevant)	EC.capillary.stress (L2)	12	64
COL1A2	02-Medium	0.36	5.74	G2	C1	fibroblast (L1), FIB.interstitial (L1S), FIB.skin_tenogenic (L1S), FIB.transitioning.secretory_procollagen (L2), IPSC.mesenchymal_primed (L2)	MAC.LAM.perivascular_angiocrine (Tier: relevant)	106 cells — complete matches	19	39
ENSG00000305533	02-Medium	0.36	4.20	G2	C1	—	—	—	10	15
ATG4C	02-Medium	0.36	16.72	G2	C1	—	—	9 cells — complete matches	1	0
NDUFS2	02-Medium	0.36	5.84	G2	C2	—	—	EC.arterial.arteriole_gas_exchange (L2), MONO.CD16.inflammatory (L2)	11	16
CELSR2	02-Medium	0.35	10.11	G2	C2	—	—	T.CD4_cytotoxic.NK_adapted (L2), T.CD8_transitional.stress (L2)	9	9
TMEM147-AS1	02-Medium	0.35	5.72	G2	C2	—	—	24 cells — complete matches	0	0
ABO	02-Medium	0.35	2.94	G2	C1	—	EC.capillary (Tier: specific)	55 cells — complete matches	185	251
GPR146	02-Medium	0.35	12.53	G2	C2	GRNLSA.angiocrine_mechanosensory (L2)	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EC.venous.adipose_lipid (Tier: specific) EC.capillary.stress (Tier: relevant)	70 cells — complete matches	19	73
GAPDHS	02-Medium	0.35	4.39	G2	C2	—	—	7 cells — complete matches	0	0
MSL2	02-Medium	0.35	5.35	G1	C2	—	—	15 cells — complete matches	12	29
ATP6V1G2-DDX39B	02-Medium	0.35	5.21	G2	C2	—	—	11 cells — complete matches	69	185
PCCB	02-Medium	0.35	6.30	G2	C2	—	—	7 cells — complete matches	2	2
LNC-RHL1	02-Medium	0.34	11.55	G1	C2	—	—	—	87	842
ENSG00000297052	02-Medium	0.34	3.36	G1	C2	—	—	—	56	146
ADAMTS4	02-Medium	0.34	4.74	G1	C2	FIB.adventitial.activated_remodelling (L2), FIB.hepatic_stellate_cell.inflammatory (L2), SMC.activated (L2)	EC.venous.adipose_lipid (Tier: specific) EC.capillary.stress (Tier: relevant)	52 cells — complete matches	15	24
ATP6V1G2	02-Medium	0.34	4.60	G2	C2	—	—	12 cells — complete matches	73	194
TMEM147	02-Medium	0.34	3.77	G2	C2	—	—	EPI.skin_follicular_keratinizing (L1S), EPI.skin_follicular_keratinizing.transit_amplifying (L2), NEU.EXC_NTNG1.synaptic (L2)	0	0
MYO1E	02-Medium	0.34	4.44	G2	C1	—	—	25 cells — complete matches	39	223
ENSG00000310423	02-Medium	0.34	4.89	G1	C2	—	—	—	15	93
ENSG00000286974	02-Medium	0.34	1.54	G1	C2	—	—	—	95	225
ENSG00000306537	02-Medium	0.33	0.59	G2	C1	—	—	—	2	2
TIRAP-AS1	02-Medium	0.33	4.76	G2	C2	—	—	—	4	2
ACAP1	02-Medium	0.33	1.17	G1	C2	MAC.kupffer.monocyte_like (L2)	MAC.kupffer.monocyte_like (Tier: relevant)	93 cells — complete matches	107	149
ENSG00000310453	02-Medium	0.33	4.04	G1	C2	—	—	—	32	132
KIRREL3	02-Medium	0.33	3.64	G2	C2	—	—	19 cells — complete matches	3	3
ENSG00000253775	02-Medium	0.33	3.71	G1	C2	—	—	—	56	138
CLIC1	02-Medium	0.33	1.85	G2	C2	PC.IgG_systemic.secretory (L2)	EC.capillary (Tier: specific)	10 cells — complete matches	159	256
ENSG00000305923	02-Medium	0.33	9.17	G1	C2	—	—	—	83	628
COX19	02-Medium	0.32	13.39	G2	C2	—	—	T.CD4_Tcm.migratory_cilium (L2), T.CD4_naive.survival_neddylation (L2)	13	52
MSH5	02-Medium	0.32	2.10	G2	C2	—	—	13 cells — complete matches	7	14
MIR3936	02-Medium	0.32	2.65	G2	C2	—	—	—	0	0
ENSG00000303243	02-Medium	0.32	4.94	G2	C2	—	—	—	5	4
TNF	02-Medium	0.32	5.56	G2	C2	B.naive.activated (L2), EC.capillary.inflammatory (L2), EPI.ectocervical_granular.inflammatory (L2), EPI.renal_principal_cell.inflammatory (L2), ILC2.activated (L2), MAC.alveolar.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2), T.CD4_Trm.activated (L2), T.CD4_cytotoxic.NK_adapted (L2), T.CD8_Trm.inflammatory (L2)	EC.capillary (Tier: specific) MAC.alveolar (Tier: specific) EC.capillary.migratory (Tier: specific) EPI.renal_distal_tubule (Tier: relevant) EC.capillary.stress (Tier: relevant) EPI.renal_distal_tubule.immune_modulatory (Tier: relevant) EPI.renal_distal_tubule.repair (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant)	111 cells — complete matches	75	194
ENSG00000306937	02-Medium	0.32	6.70	G2	C2	—	—	—	11	33
OASL	02-Medium	0.32	13.21	G1	C2	—	EC.capillary (Tier: specific) MAC.alveolar (Tier: specific) EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EC.capillary.stress (Tier: relevant) EPI.ileal_goblet.baseline (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant)	88 cells — complete matches	57	132
MICB	02-Medium	0.32	3.78	G2	C2	—	—	43 cells — complete matches	294	633
MICB-DT	02-Medium	0.32	3.77	G2	C2	—	—	—	131	286
KIRREL3-AS1	02-Medium	0.32	3.23	G2	C2	—	—	—	0	0
B4GALT3	02-Medium	0.31	7.21	G1	C2	—	—	4 cells — complete matches	9	14
ENSG00000303738	02-Medium	0.31	7.41	G2	C2	—	—	—	0	0
LINC01766	02-Medium	0.31	5.81	G2	C2	—	—	DC.pDC.poised_migratory (L2)	0	0
ENSG00000266997	02-Medium	0.31	7.07	G2	C1	—	—	—	2	3
MPZ	02-Medium	0.31	2.03	G2	C1	schwann_cell (L1), SCHWN.schwann_cell (L1S)	—	30 cells — complete matches	11	16
FAM157D	02-Medium	0.31	5.82	G2	C2	—	—	—	23	54
FAM81A	02-Medium	0.31	3.60	G2	C1	—	EPI.renal_principal_cell (Tier: specific) EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) EPI.renal_intercalated_cell_type_A.PC_transitional (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EPI.renal_principal_cell.activated_acute (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant)	36 cells — complete matches	26	96
ENSG00000306875	02-Medium	0.31	3.57	G2	C1	—	—	—	34	110
ATP4A	02-Medium	0.31	5.22	G2	C2	—	—	—	0	0
ENSG00000296731	02-Medium	0.30	7.32	G1	C2	—	—	—	3	13
WDR35-DT	02-Medium	0.30	4.00	G1	C2	—	—	—	16	43
MATN3	02-Medium	0.30	3.41	G1	C2	chondrocyte (L1), CHOND.chondrocyte (L1S)	—	30 cells — complete matches	17	44
ENSG00000259732	02-Medium	0.30	2.39	G2	C1	—	—	—	26	37
MED22	02-Medium	0.30	0.87	G2	C2	—	—	22 cells — complete matches	29	42
TIRAP	02-Medium	0.30	2.54	G2	C2	—	—	28 cells — complete matches	4	2
ENSG00000303197	02-Medium	0.30	5.84	G2	C2	—	—	—	2	13
CCNB2	02-Medium	0.30	2.80	G2	C1	EPI.esophageal_suprabasal.proliferative_exit (L2), EPI.ileal_enterocyte_crypt.proliferative_G2M (L2), EPI.skin_sweat_duct_keratinocyte.proliferative_G2M (L2)	EPI.ileal_enterocyte_crypt (Tier: relevant)	59 cells — complete matches	15	22
SBSN	02-Medium	0.30	4.09	G2	C2	EPI.skin_interfollicular_spinous.upper_lipid (L2)	—	46 cells — complete matches	0	0
WDR35	02-Medium	0.30	3.18	G1	C2	—	—	19 cells — complete matches	18	43
ENSG00000288670	02-Medium	0.30	1.99	G2	C1	—	—	—	11	16
MSH5-SAPCD1	02-Medium	0.30	1.72	G2	C2	—	—	15 cells — complete matches	7	13
ENSG00000267188	02-Medium	0.30	8.18	G2	C1	—	—	—	0	0
SNHG32	02-Medium	0.30	2.12	G2	C2	—	—	—	38	69
ZNF229	02-Medium	0.30	7.93	G2	C1	—	—	5 cells — complete matches	0	0
ENSG00000289106	02-Medium	0.30	1.76	G2	C1	—	—	—	10	15
VASP	02-Medium	0.29	0.38	G2	C2	EPI.thymic_cortical.Notch_interface (L2)	—	T.CD4_Tem.transitional_CM (L2)	27	117
FCGR2B	02-Medium	0.29	1.84	G2	C1	EC.liver_sinusoidal (L1S), DC.cDC2.tolerogenic_regulatory (L2), HEP.canalicular_transport.secretory_ERAD_UPR (L2), MAC.alveolar.capillary_interacting (L2), MAC.resident_iron.APC_iron_sensing (L2)	MAC.alveolar (Tier: specific) EPI.colonic_tuft (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.kupffer.monocyte_like (Tier: relevant)	86 cells — complete matches	209	293
ENSG00000297068	02-Medium	0.29	2.24	G2	C1	—	—	—	11	16
ENSG00000299497	02-Medium	0.29	5.54	G2	C2	—	—	—	0	0
SDHC	02-Medium	0.29	2.14	G2	C1	—	—	EPI.alveolar_type_1.baseline (L2), EPI.salivary_serous_acinar.secretory_active (L2)	11	16
BAG6	02-Medium	0.29	2.43	G2	C2	—	—	MONO.CD16.inflammatory (L2)	73	116
RELB	02-Medium	0.29	15.36	G2	C2	DC.mig.baseline (L2), EPI.colonocyte.junction_remodeling (L2), EPI.pancreatic_ductal_bicarbonate.inflammatory (L2), FIB.suburothelial.inflammatory_prostanoid (L2), GRNLSA.lipid_hypoxia (L2)	EPI.renal_distal_tubule (Tier: relevant) EPI.renal_distal_tubule.immune_modulatory (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant)	23 cells — complete matches	41	86
SNORD52	02-Medium	0.29	1.10	G2	C2	—	—	—	32	55
PPOX	02-Medium	0.29	3.54	G2	C2	—	—	10 cells — complete matches	11	21
SURF4	02-Medium	0.29	0.83	G1	C2	—	—	EPI.alveolar_type_1.baseline (L2), ILC2.migratory (L2)	29	41
ENSG00000290115	02-Medium	0.29	3.53	G2	C2	—	—	—	31	74
CABP1	02-Medium	0.28	7.03	G1	C2	—	—	29 cells — complete matches	36	73
MYZAP	02-Medium	0.28	5.84	G2	C1	—	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) EPI.renal_intercalated_cell_type_A.PC_transitional (Tier: specific) EPI.colonic_tuft (Tier: relevant) EC.capillary.stress (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant)	63 cells — complete matches	42	273
DMKN	02-Medium	0.28	3.27	G2	C2	EPI.skin_interfollicular_spinous.baseline (L2), EPI.skin_keratinocyte_basal.spinous_transition (L2), EPI.skin_keratinocyte_progenitor.quiescent_stem_like (L2), EPI.skin_keratinocyte_proliferating.early_spinous_transition (L2), EPI.skin_sebaceous_duct_luminal.detox_repair (L2)	EPI.renal_immature_ureteric_bud (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant)	82 cells — complete matches	67	112
ENSG00000300813	02-Medium	0.28	9.30	G2	C2	—	—	—	0	0
PPP1R13L	02-Medium	0.28	0.77	G2	C2	—	EC.capillary (Tier: specific) EC.capillary.stress (Tier: relevant)	15 cells — complete matches	2	1
GCOM1	02-Medium	0.28	5.72	G2	C1	—	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) EPI.renal_intercalated_cell_type_A.PC_transitional (Tier: specific) EPI.colonic_tuft (Tier: relevant) EC.capillary.stress (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant)	66 cells — complete matches	42	273
ENSG00000295231	02-Medium	0.28	2.75	G2	C2	—	—	—	0	0
POLR1G	02-Medium	0.28	0.46	G2	C2	—	—	—	0	0
RNF111	02-Medium	0.28	4.64	G2	C1	—	—	7 cells — complete matches	3	8
ENSG00000309394	02-Medium	0.28	5.72	G2	C2	—	—	—	0	0
ZNF285	02-Medium	0.28	6.60	G2	C1	—	—	22 cells — complete matches	0	0
ENSG00000267173	02-Medium	0.28	6.46	G2	C1	—	—	—	0	0
ERCC1	02-Medium	0.28	0.19	G2	C2	—	—	EPI.ectocervical_granular.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2)	7	10
STKLD1	02-Medium	0.28	0.76	G1	C2	—	—	14 cells — complete matches	29	41
SNORD48	02-Medium	0.27	1.98	G2	C2	—	—	—	1	6
ENSG00000302425	02-Medium	0.27	2.01	G2	C1	—	—	—	79	451
ENSG00000301327	02-Medium	0.27	2.57	G1	C2	—	—	—	32	74
REXO4	02-Medium	0.27	0.82	G2	C2	—	—	6 cells — complete matches	45	64
ENSG00000304067	02-Medium	0.26	3.02	G2	C1	—	—	—	81	426
UFC1	02-Medium	0.26	5.19	G1	C2	—	—	EC.heart_remodeling (L1S), GRANU.MAST (L1S), EC.heart_remodeling.translation_boost (L2)	2	2
P4HA2	02-Medium	0.26	1.85	G1	C2	—	HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant)	14 cells — complete matches	213	354
ENSG00000286493	02-Medium	0.26	4.32	G1	C2	—	—	—	24	56
ADAMTS13	02-Medium	0.26	1.12	G2	C2	—	—	20 cells — complete matches	37	50
ACADS	02-Medium	0.25	5.46	G1	C2	—	EPI.ileal_enterocyte_absorptive (Tier: relevant)	5 cells — complete matches	21	53
ENSG00000283696	02-Medium	0.25	1.34	G1	C2	—	—	—	11	17
ENSG00000288093	02-Medium	0.25	1.34	G1	C2	—	—	—	11	17
PDLIM4	02-Medium	0.25	2.29	G1	C2	EPI.salivary_intercalated_defense.inflammatory (L2)	EC.capillary (Tier: specific) EPI.renal_thick_ascending_limb (Tier: specific) EPI.colonocyte.ionocyte_BEST4 (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: relevant) EPI.renal_thick_ascending_limb.cation_flux (Tier: relevant)	70 cells — complete matches	171	263
SURF1	02-Medium	0.24	0.84	G1	C2	—	—	T.CD4_Tcm.APC_mimicry (L2)	27	40
SURF2	02-Medium	0.24	0.79	G1	C2	—	—	—	35	74
LY6H	02-Medium	0.24	4.21	G2	C2	EC.capillary.angiogenic_tip (L2), EPI.pancreatic_islet.delta (L2), FIB.neurolectin_mucosa.axon_responsive (L2), OPC.premyelinating (L2), THYMO.DN_preTCR (L2)	EC.capillary (Tier: specific) EC.capillary.migratory (Tier: specific) EPI.colonic_tuft (Tier: relevant)	40 cells — complete matches	0	0
ENSG00000298585	02-Medium	0.24	0.36	G2	C2	—	—	—	20	92
LINC02964	02-Medium	0.24	0.28	G2	C1	—	—	—	75	450
ZFP41	02-Medium	0.24	3.35	G2	C2	—	—	17 cells — complete matches	1	1
SPPL3	02-Medium	0.24	5.24	G2	C1	—	—	T.CD4_Treg.Tr1_like (L2), T.CD4_transitional.tissue_enagement (L2)	22	53
ENSG00000309463	02-Medium	0.24	1.72	G2	C2	—	—	—	0	0
HAUS5	02-Medium	0.24	1.98	G2	C2	—	—	10 cells — complete matches	0	0
TNXB	02-Medium	0.24	1.19	G2	C2	GRANU.neutrophil.antiviral_endotoxin (L2)	EPI.ileal_goblet.stress_metallothionein (Tier: relevant)	27 cells — complete matches	153	526
ENSG00000307923	02-Medium	0.24	0.35	G2	C2	—	—	—	371	796
SNORD36A	02-Medium	0.24	0.94	G1	C2	—	—	—	28	41
SNORD36B	02-Medium	0.24	0.94	G1	C2	—	—	—	28	41
SNORD36C	02-Medium	0.24	0.94	G1	C2	—	—	—	28	41
ENSG00000303834	02-Medium	0.24	1.48	G2	C1	—	—	—	81	714
NEU1	02-Medium	0.23	1.09	G2	C2	—	EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant)	7 cells — complete matches	26	37
LY6L	02-Medium	0.23	4.53	G2	C2	—	—	—	0	0
SURF6	02-Medium	0.23	0.80	G1	C2	—	—	7 cells — complete matches	27	40
UNC119B	02-Medium	0.23	5.66	G2	C1	—	EC.capillary.migratory (Tier: specific)	21 cells — complete matches	17	29
ENSG00000279001	02-Medium	0.23	3.58	G2	C2	—	—	—	3	1
CLASRP	02-Medium	0.22	14.53	G2	C2	—	—	B.naive.baseline (L2), B.naive.proteostasis (L2)	15	15
ERCC2	02-Medium	0.22	1.14	G2	C2	—	—	10 cells — complete matches	5	39
CACFD1	02-Medium	0.22	1.32	G1	C2	—	—	12 cells — complete matches	52	72
STAG1	02-Medium	0.22	5.06	G2	C2	—	—	EPI.alveolar_type_1.activated (L2), MAC.MDM.APC_dendritic (L2)	3	3
POP5	02-Medium	0.22	4.59	G2	C1	—	—	—	19	32
PPM1N	02-Medium	0.21	0.47	G2	C2	EPI.thymic_cortical.Notch_interface (L2), MONO.CD16.patrolling (L2)	—	41 cells — complete matches	23	103
SH2D4A	02-Medium	0.21	0.23	G1	C2	—	—	9 cells — complete matches	18	46
RTN2	02-Medium	0.21	0.40	G2	C2	—	MAC.LAM.perivascular_angiocrine (Tier: relevant)	19 cells — complete matches	21	92
LPAL2.2	02-Medium	0.21	0.95	G2	C1	—	—	—	122	986
INTS10	02-Medium	0.21	1.06	G1	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2)	—	B.naive.proteostasis (L2), EC.liver_sinusoidal.secretory_lipoprotein (L2), EPI.hepatic_ductular_cholangiocyte.secretory_transport (L2)	23	48
FOSB	02-Medium	0.21	0.12	G2	C2	ASPC.activated (L2), B.naive.activated (L2), EC.heart_remodeling.activated_acute (L2), EPI.colonocyte.crypt_progenitor (L2), EPI.pancreatic_ductal_bicarbonate.activated (L2), EPI.salivary_myoepithelial.activated (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), FIB.reticular.stromal_niche (L2), GRNLSA.EMT_insulin_signaling (L2), HEP.periportal_metabolic.stress_chaperone (L2), MEL.dedifferentiated_migratory (L2), MESO.activated_stress (L2), PC.IgG_systemic.interacting (L2), SMC.activated (L2), T.CD4_Tfh.precursor_migratory (L2), T.CD4_Trm.activated (L2)	EPI.ileal_enterocyte_absorptive.brush_border (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: specific) EC.capillary.stress (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	74 cells — complete matches	10	20
GLI4	02-Medium	0.21	3.11	G2	C2	—	—	6 cells — complete matches	22	72
ENSG00000299344	02-Medium	0.20	0.17	G2	C2	—	—	—	7	19
CSGALNACT1	02-Medium	0.20	0.24	G1	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2), EPI.pancreatic_islet.alpha (L2)	EPI.renal_thick_ascending_limb (Tier: specific) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (Tier: relevant)	85 cells — complete matches	17	41
KLC3	02-Medium	0.20	4.63	G2	C2	—	EPI.ileal_goblet.stress_metallothionein (Tier: relevant)	58 cells — complete matches	6	42
LPA	02-Medium	0.20	0.99	G2	C1	—	hepatocyte (Tier: specific) HEP.acute_phase (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant)	7 cells — complete matches	89	880
P2RX7	02-Medium	0.20	2.32	G2	C1	—	HEP.periportal_metabolic (Tier: specific) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant)	42 cells — complete matches	6	9
EML2-AS1	02-Medium	0.19	0.27	G2	C2	—	—	—	21	92
ENSG00000299359	02-Medium	0.19	0.19	G2	C2	—	—	—	5	7
EML2	02-Medium	0.18	0.26	G2	C2	—	—	4 cells — complete matches	25	94
KANK4	02-Medium	0.18	7.52	G2	C1	—	—	23 cells — complete matches	2	2
LAPTM4A	02-Medium	0.18	2.86	G2	C2	EPI.alveolar_type_2.baseline_surfactant (L2), EPI.pancreatic_ductal_bicarbonate.junctional_remodel (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2)	EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant)	8 cells — complete matches	14	22
GML	02-Medium	0.18	0.88	G2	C2	—	—	—	0	2
ENSG00000224077	02-Medium	0.18	6.05	G2	C2	—	—	—	63	346
ENSG00000304183	02-Medium	0.18	0.24	G2	C2	—	—	—	20	91
LY6S	02-Medium	0.18	1.79	G2	C2	—	—	—	0	2
LY6S-AS1	02-Medium	0.17	1.51	G2	C2	—	—	—	0	0
ENSG00000254607	02-Medium	0.17	2.46	G2	C2	—	—	—	0	0
LINC01739	02-Medium	0.16	5.44	G2	C1	—	—	—	0	0
L1TD1	02-Medium	0.16	5.12	G2	C1	EPI.colonocyte.goblet_interface (L2)	MAC.alveolar (Tier: specific) MAC.LAM.lipid_phagocytosis (Tier: specific) EPI.ileal_goblet.baseline (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant)	40 cells — complete matches	2	2
PPP2R3A	02-Medium	0.11	3.92	G2	C2	—	—	5 cells — complete matches	27	98
IL20RB	02-Medium	0.05	1.76	G2	C2	—	—	52 cells — complete matches	20	45

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.