Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90241978 · All tissues

MINPP1 levels: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: MINPP1 levels

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte_precursor_cell	44.90	Significant	1.84e-15	1.57	Specific	461	1,454
2	thymocyte	16.30	Significant	3.57e-22	1.42	Specific	168	512
3	cardiomyocyte	16.03	Significant	1.04e-41	1.39	Specific	533	2,045
4	natural_killer_cell	8.12	Significant	7.18e-14	1.16	Specific	1,204	2,052
5	T_cell	8.06	Significant	3.30e-49	1.30	Specific	470	959
6	microglia	7.77	Significant	1.00	1.05	Relevant	61	129
7	neuron	5.51	Significant	1.00	0.95	Other	330	1,328
8	mesothelial_cell	5.43	Nominal	1.00	0.86	Other	6	36
9	skeletal_muscle_cell	5.06	Nominal	0.06	1.08	Other	944	2,600
10	epithelial_cell	1.95	Nonsignificant	1.00	0.82	Other	24	47
11	B_cell	1.69	Nonsignificant	1.00	0.81	Other	356	694
12	endothelial_cell	1.45	Nonsignificant	1.00	0.92	Other	373	974
13	astrocyte	1.27	Nonsignificant	1.00	0.80	Other	256	1,203
14	hepatocyte	1.10	Nonsignificant	1.00	0.78	Other	1,515	3,822
15	plasma_cell	0.84	Nonsignificant	1.00	0.68	Other	17	24
16	macrophage	0.80	Nonsignificant	1.00	0.73	Other	813	1,732
17	induced_pluripotent_stem_cell	0.78	Nonsignificant	1.00	0.69	Other	0	0
18	innate_lymphoid_cell_2	0.77	Nonsignificant	1.00	0.67	Other	3	8
19	granulosa_cell	0.43	Nonsignificant	1.00	0.65	Other	293	670
20	haematopoietic_progenitor_cell	0.14	Nonsignificant	1.00	0.52	Other	262	502
21	granulocyte	0.09	Nonsignificant	1.00	0.54	Other	5	6
22	muscle_stem_cell	0.09	Nonsignificant	1.00	0.45	Other	7	27
23	smooth_muscle_cell	0.08	Nonsignificant	1.00	0.44	Other	27	139
24	dendritic_cell	0.05	Nonsignificant	1.00	0.50	Other	496	724
25	chondrocyte	0.03	Nonsignificant	1.00	0.51	Other	548	1,069
26	monocyte	0.03	Nonsignificant	1.00	0.34	Other	2,176	3,871
27	fibroblast	0.03	Nonsignificant	1.00	0.36	Other	184	826
28	platelet	0.03	Nonsignificant	—	0.00	Other	85	104
29	adipose_stem_and_progenitor_cell	0.02	Nonsignificant	1.00	0.37	Other	327	954
30	oligodendrocyte	0.02	Nonsignificant	1.00	0.36	Other	385	1,507
31	melanocyte	0.01	Nonsignificant	1.00	0.42	Other	97	309
32	schwann_cell	9.71e-03	Nonsignificant	1.00	0.30	Other	10	57
33	pericyte	7.08e-03	Nonsignificant	1.00	0.28	Other	128	517
34	adipocyte	2.88e-04	Nonsignificant	1.00	0.17	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OPC.oligodendrocyte_precursor_cell	44.90	Significant	—	—	Specific	413	1,269
2	THYMO.thymocyte	16.30	Significant	—	—	Specific	163	495
3	CM.cardiomyocyte	16.03	Significant	—	—	Specific	524	2,032
4	EPI.intrahepatic_cholangiocyte_transport	14.44	Significant	—	1.47	Relevant	12	42
5	NEU.EXC_CT	14.17	Significant	9.13e-04	1.84	Specific	362	384
6	T.CD4_Tcm	12.12	Significant	3.58e-19	1.79	Specific	494	988
7	T.CD8_Tcm	11.29	Significant	0.04	1.34	Specific	460	926
8	T.CD4_Th17	10.97	Significant	0.16	1.26	Relevant	421	794
9	T.CD4_naive	10.41	Significant	8.63e-19	1.58	Specific	399	866
10	T.CD8_Tem	10.30	Significant	8.75e-04	1.32	Specific	1,083	1,857
11	EC.lymphatic	10.04	Significant	7.27e-03	1.15	Specific	630	998
12	EPI.salivary_serous_acinar	9.93	Significant	4.43e-13	1.34	Specific	233	531
13	EPI.ileal_goblet	9.28	Significant	0.11	1.26	Relevant	181	432
14	T.CD8_naive	9.17	Significant	0.51	1.07	Specific	317	708
15	T.CD4_cytotoxic	8.91	Significant	1.00	0.88	Relevant	855	1,493
16	T.CD4_Treg	8.65	Significant	1.04e-06	1.77	Specific	244	511
17	NK.natural_killer_cell	8.12	Significant	—	—	Specific	1,204	2,045
18	MG.microglia	7.77	Significant	—	—	—	49	0
19	EPI.colonic_tuft	6.74	Significant	—	1.26	Relevant	7	24
20	SKM.type_1_slow	6.59	Significant	9.45e-28	4.16	Specific	923	2,478
21	EPI.renal_principal_cell	6.39	Significant	0.15	1.19	Relevant	207	403
22	EC.heart_remodeling	6.24	Significant	7.58e-10	1.22	Specific	569	1,594
23	T.gamma_delta	5.83	Significant	1.00	0.72	Other	588	1,078
24	T.CD4_Tem	5.59	Significant	1.00	0.47	Other	365	697
25	MESO.mesothelial_cell	5.43	Nominal	—	—	Other	2	18
26	NEU.EXC_IT	5.29	Nominal	0.28	1.22	Other	411	192
27	EPI.pancreatic_ductal_mucinous	5.26	Nominal	1.00	1.11	Other	219	430
28	T.CD4_Th2	5.08	Nominal	—	0.00	Other	1	2
29	T.CD4_transitional	4.99	Nominal	1.00	0.50	Other	48	110
30	NEU.INH_PVALB	4.94	Nominal	0.90	0.98	Other	193	183
31	MAC.microglia_like	4.56	Nominal	0.13	1.32	Other	124	179
32	MAC.kupffer	4.50	Nominal	0.06	1.30	Other	189	530
33	T.CD8_transitional	4.17	Nominal	1.00	0.32	Other	497	932
34	NEU.INH_LAMP5	4.08	Nominal	0.95	0.79	Other	263	532
35	EC.liver_sinusoidal	4.06	Nominal	0.27	1.06	Other	1,083	1,925
36	SKM.type_2_fast	3.93	Nominal	1.00	0.00	Other	972	2,639
37	EPI.alveolar_type_1	3.76	Nominal	1.00	1.08	Other	26	101
38	T.CD4_Tfh	3.71	Nominal	1.00	0.63	Other	47	45
39	EPI.endocervical_secretory	3.66	Nominal	—	0.33	Other	0	0
40	NEU.EXC_NTNG1	3.40	Nominal	—	0.00	Other	0	0
41	EPI.renal_distal_tubule	3.17	Nominal	1.00	1.01	Other	133	361
42	EPI.tracheal_basal	3.09	Nominal	1.00	1.04	Other	398	1,120
43	T.MAIT	2.90	Nonsignificant	1.00	0.36	Other	469	855
44	EPI.colonic_enteroendocrine	2.88	Nonsignificant	—	0.83	Other	1	1
45	NEU.INH_VIP	2.40	Nonsignificant	1.00	0.10	Other	241	366
46	EPI.hepatic_ductular_cholangiocyte	2.39	Nonsignificant	1.00	1.00	Other	83	243
47	EPI.pancreatic_islet	2.20	Nonsignificant	1.00	0.92	Other	52	132
48	EPI.ileal_enterocyte_absorptive	2.12	Nonsignificant	1.00	0.87	Other	118	338
49	EPI.ileal_enterocyte_crypt	1.93	Nonsignificant	1.00	0.96	Other	67	113
50	EPI.tracheal_suprabasal	1.92	Nonsignificant	1.00	0.90	Other	29	56
51	HEP.periportal_metabolic	1.89	Nonsignificant	1.71e-07	1.29	Other	1,750	4,427
52	B.memory	1.84	Nonsignificant	0.82	1.10	Other	442	882
53	EPI.salivary_intercalated_defense	1.72	Nonsignificant	1.00	0.88	Other	81	161
54	B.naive	1.66	Nonsignificant	0.92	1.01	Other	307	595
55	MAC.resident_cardiac	1.54	Nonsignificant	5.73e-03	1.23	Other	485	1,074
56	EPI.tracheal_submucosal_gland	1.50	Nonsignificant	—	0.60	Other	0	0
57	EPI.extrahepatic_cholangiocyte	1.38	Nonsignificant	—	0.32	Other	37	71
58	EPI.renal_intercalated_cell_type_A	1.33	Nonsignificant	1.00	0.78	Other	67	142
59	EPI.colonocyte	1.27	Nonsignificant	1.00	0.91	Other	294	815
60	ASTRO.astrocyte	1.27	Nonsignificant	—	—	Other	228	1,111
61	T.CD4_Trm	1.24	Nonsignificant	1.00	0.06	Other	176	363
62	B.germinal_center	1.11	Nonsignificant	1.00	0.60	Other	233	655
63	HEP.canalicular_transport	1.07	Nonsignificant	0.26	1.05	Other	1,290	3,434
64	MAC.resident_repair	0.92	Nonsignificant	1.00	1.01	Other	796	1,426
65	PC.IgA_muocsal	0.90	Nonsignificant	8.70e-04	1.65	Other	18	31
66	EPI.salivary_mucous_acinar	0.90	Nonsignificant	1.00	0.85	Other	639	1,189
67	IPSC.induced_pluripotent_stem_cell	0.78	Nonsignificant	—	—	Other	0	0
68	ILC2.innate_lymphoid_cell_2	0.77	Nonsignificant	—	—	Other	2	0
69	EPI.ileal_bile_transport	0.76	Nonsignificant	1.00	0.83	Other	61	93
70	MAC.resident_iron	0.70	Nonsignificant	1.00	0.85	Other	16	21
71	EPI.renal_thick_ascending_limb	0.64	Nonsignificant	1.00	0.74	Other	453	1,153
72	T.CD8_Trm	0.56	Nonsignificant	1.00	0.01	Other	211	346
73	NEU.EXC_SYT2	0.53	Nonsignificant	—	0.00	Other	40	77
74	EPI.gastric_foveolar	0.52	Nonsignificant	—	0.19	Other	0	0
75	EPI.cervical_suprabasal	0.47	Nonsignificant	—	0.17	Other	14	50
76	PC.IgG_systemic	0.43	Nonsignificant	1.00	0.38	Other	41	60
77	GRNLSA.granulosa_cell	0.43	Nonsignificant	—	—	Other	257	0
78	EPI.renal_intercalated_cell_type_B	0.33	Nonsignificant	—	0.12	Other	6	7
79	EC.venous	0.26	Nonsignificant	1.00	0.73	Other	516	1,387
80	FIB.reticular	0.22	Nonsignificant	0.03	1.37	Other	19	87
81	MAC.MDM	0.21	Nonsignificant	1.00	0.74	Other	623	986
82	EPI.pancreatic_ductal_bicarbonate	0.19	Nonsignificant	1.00	0.65	Other	131	548
83	MAC.LAM	0.19	Nonsignificant	1.00	0.58	Other	914	2,064
84	EPI.intrahepatic_cholangiocyte_defense	0.19	Nonsignificant	—	0.00	Other	8	13
85	HPC.haematopoietic_progenitor_cell	0.14	Nonsignificant	—	—	Other	211	370
86	FIB.skin_sheath	0.14	Nonsignificant	0.33	1.31	Other	49	118
87	GRANU.MAST	0.14	Nonsignificant	9.43e-04	1.68	Other	5	6
88	EC.arterial	0.13	Nonsignificant	1.00	0.51	Other	356	885
89	EPI.ectocervical_granular	0.11	Nonsignificant	—	0.00	Other	11	23
90	B.age_associated	0.10	Nonsignificant	1.00	0.00	Other	207	350
91	MAC.proliferating	0.10	Nonsignificant	1.00	0.77	Other	87	253
92	FIB.neurolectin_mucosa	0.09	Nonsignificant	0.41	1.14	Other	133	394
93	DC.cDC1	0.09	Nonsignificant	0.01	1.27	Other	55	112
94	MUSC.muscle_stem_cell	0.09	Nonsignificant	—	—	Other	4	18
95	MONO.CD16	0.08	Nonsignificant	5.68e-06	1.18	Other	1,304	1,835
96	SMC.smooth_muscle_cell	0.08	Nonsignificant	—	—	Other	20	101
97	FIB.suburothelial	0.07	Nonsignificant	0.37	1.18	Other	122	432
98	EPI.salivary_duct_excretory	0.06	Nonsignificant	1.00	0.57	Other	85	180
99	DC.cDC2	0.06	Nonsignificant	3.73e-03	1.23	Other	1,189	1,793
100	EPI.skin_appendage_keratinocyte	0.06	Nonsignificant	1.00	0.68	Other	87	222
101	EPI.thymic_medullary	0.06	Nonsignificant	1.00	0.55	Other	26	133
102	EPI.lung_multiciliated	0.06	Nonsignificant	1.00	0.55	Other	16	49
103	HEP.acute_phase	0.05	Nonsignificant	1.00	0.30	Other	1,441	3,641
104	FIB.barrier_purinergic	0.05	Nonsignificant	—	0.78	Other	1	3
105	FIB.barrier_secretory	0.04	Nonsignificant	0.59	1.15	Other	81	228
106	FIB.perivascular_interface	0.03	Nonsignificant	0.82	0.99	Other	0	0
107	EPI.renal_immature_ureteric_bud	0.03	Nonsignificant	1.00	0.51	Other	217	569
108	CHOND.chondrocyte	0.03	Nonsignificant	—	—	Other	519	730
109	FIB.skin_neurosecretory	0.03	Nonsignificant	—	0.79	Other	0	0
110	DC.mig	0.03	Nonsignificant	—	0.54	Other	89	156
111	PLAT.platelet	0.03	Nonsignificant	—	0.00	Other	38	53
112	EPI.esophageal_basal	0.02	Nonsignificant	1.00	0.54	Other	4	10
113	FIB.hepatic_stellate_cell	0.02	Nonsignificant	—	0.68	Other	64	252
114	FIB.skin_tenogenic	0.02	Nonsignificant	—	0.62	Other	108	227
115	EPI.pancreatic_ductal_perivascular	0.02	Nonsignificant	1.00	0.55	Other	4	30
116	ASPC.adipose_stem_and_progenitor_cell	0.02	Nonsignificant	—	—	Other	324	930
117	EC.capillary	0.02	Nonsignificant	1.00	0.12	Other	514	1,635
118	EPI.skin_keratinocyte_progenitor	0.02	Nonsignificant	—	0.00	Other	0	3
119	OLG.oligodendrocyte	0.02	Nonsignificant	—	—	Other	384	1,397
120	MONO.CD14	0.02	Nonsignificant	1.00	0.42	Other	2,294	4,139
121	MEL.melanocyte	0.01	Nonsignificant	—	—	Other	79	242
122	FIB.tracheal_subepithelial	0.01	Nonsignificant	—	0.26	Other	0	0
123	FIB.skin_papillary	0.01	Nonsignificant	—	0.49	Other	0	0
124	FIB.adventitial	0.01	Nonsignificant	1.00	0.86	Other	268	1,447
125	FIB.interstitial	0.01	Nonsignificant	1.00	0.73	Other	288	940
126	SCHWN.schwann_cell	9.71e-03	Nonsignificant	—	—	Other	7	33
127	EPI.renal_proximal_tubule	9.08e-03	Nonsignificant	1.00	0.49	Other	525	806
128	EPI.skin_keratinocyte_basal	8.68e-03	Nonsignificant	—	0.00	Other	13	26
129	FIB.lung_alveolar	7.85e-03	Nonsignificant	—	0.00	Other	6	15
130	PERI.pericyte	7.08e-03	Nonsignificant	—	—	Other	117	0
131	EPI.lung_club_secretory	6.59e-03	Nonsignificant	1.00	0.44	Other	5	14
132	EPI.thymic_cortical	6.21e-03	Nonsignificant	1.00	0.58	Other	442	824
133	HEP.pericentral_lipoprotein	5.76e-03	Nonsignificant	—	0.00	Other	0	0
134	FIB.transitioning	5.30e-03	Nonsignificant	1.00	0.59	Other	172	497
135	EPI.pancreatic_acinar	5.06e-03	Nonsignificant	1.00	0.61	Other	429	1,475
136	EPI.alveolar_type_2	3.61e-03	Nonsignificant	1.00	0.49	Other	813	1,853
137	EPI.skin_interfollicular_spinous	2.81e-03	Nonsignificant	1.00	0.35	Other	260	563
138	EPI.salivary_myoepithelial	2.69e-03	Nonsignificant	1.00	0.38	Other	191	714
139	EPI.bile_duct_cholangiocyte	2.46e-03	Nonsignificant	1.00	0.39	Other	37	60
140	EPI.salivary_duct_ion_transport	2.42e-03	Nonsignificant	1.00	0.35	Other	5	11
141	EPI.skin_follicular_keratinizing	2.16e-03	Nonsignificant	1.00	0.28	Other	30	81
142	GRANU.neutrophil	2.06e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
143	EPI.skin_hair_follicle_bulge	1.87e-03	Nonsignificant	1.00	0.33	Other	51	178
144	EPI.skin_sweat_duct_keratinocyte	1.32e-03	Nonsignificant	1.00	0.44	Other	146	301
145	EPI.esophageal_suprabasal	1.02e-03	Nonsignificant	1.00	0.26	Other	158	404
146	EPI.pancreatic_ductal_progenitor	8.56e-04	Nonsignificant	1.00	0.27	Other	234	873
147	EPI.skin_sebaceous_duct_luminal	7.51e-04	Nonsignificant	1.00	0.30	Other	100	249
148	ADIPO.adipocyte	2.88e-04	Nonsignificant	—	—	Other	20	62
149	EPI.skin_keratinocyte_proliferating	1.23e-04	Nonsignificant	1.00	0.16	Other	47	76
150	MAC.alveolar	6.25e-05	Nonsignificant	1.00	2.08e-03	Other	1,432	3,122
151	DC.pDC	3.11e-05	Nonsignificant	1.00	0.26	Other	496	1,028
152	EPI.skin_hair_follicle_companion	1.05e-05	Nonsignificant	—	0.00	Other	8	12

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OPC.proliferative_immune_interact	49.49	Significant	0.20	1.64	Specific	180	373
2	OPC.homeostatic	48.47	Significant	0.24	1.41	—	394	160
3	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	41.61	Significant	—	1.15	—	0	0
4	OPC.premyelinating	37.72	Significant	0.99	0.16	—	185	12
5	NEU.EXC_CT.Ca2_sensor	29.59	Significant	—	1.44	Relevant	0	0
6	THYMO.DP_early	26.27	Significant	2.33e-06	1.86	—	326	313
7	THYMO.SP_CD8_naive	19.48	Significant	0.30	1.23	—	297	177
8	THYMO.SP_CD4_naive	19.30	Significant	1.00	0.92	—	65	75
9	CM.anti_inflammatory	18.67	Significant	0.39	1.44	Specific	424	1,503
10	CM.mito_proteostasis	17.56	Significant	0.39	1.35	—	329	29
11	CM.translation_boost_RPS	17.47	Significant	1.00	0.79	—	69	16
12	CM.oxidative_phospho	17.36	Significant	0.39	1.33	Specific	266	792
13	NEU.EXC_CT.remodeling	16.86	Significant	—	0.09	—	23	1
14	CM.sarcomere_actin_interface	16.78	Significant	0.83	1.05	—	450	78
15	CM.translation_boost_RPL	16.29	Significant	1.00	0.89	—	129	1
16	CM.osmoprotection	16.05	Significant	0.83	1.07	Relevant	34	57
17	CM.baseline	15.50	Significant	1.00	0.73	—	393	0
18	T.CD4_Tcm.APC_mimicry	15.25	Significant	0.07	1.87	—	54	43
19	MAC.kupffer.metabolic	15.21	Significant	—	1.39	Relevant	25	36
20	T.CD4_Tcm.synapse_dynamics	15.09	Significant	0.43	1.48	—	15	10
21	T.CD4_Tcm.Th2_like	14.52	Significant	0.46	1.39	Relevant	23	55
22	T.CD4_Th17.migratory	14.30	Significant	0.33	1.46	Relevant	13	23
23	THYMO.CD8aa_IELp	13.86	Significant	—	0.00	—	1	7
24	T.CD4_Tcm.DC_interact	13.73	Significant	0.24	1.57	—	72	32
25	T.CD8_Tcm.helper_like	13.60	Significant	6.03e-03	2.12	Specific	81	159
26	T.CD4_Tcm.migratory_cilium	13.53	Significant	0.78	1.15	—	5	10
27	T.CD4_Tcm.secretory	13.50	Significant	0.78	1.11	—	20	11
28	CM.mechano_activated	13.36	Significant	1.00	0.45	—	205	134
29	T.CD4_Tcm.retro_ZNF117	13.36	Significant	0.78	1.10	Relevant	5	9
30	T.CD8_Tcm.NK_like	13.04	Significant	0.43	1.27	Relevant	334	581
31	EC.lymphatic.scavenger	12.83	Significant	0.11	1.86	Relevant	203	257
32	T.CD8_Tcm.baseline	12.81	Significant	0.29	1.42	—	90	89
33	T.CD4_naive.Treg_like	12.69	Significant	0.49	1.78	—	121	72
34	T.CD4_Tcm.RNA_control	12.66	Significant	0.87	0.96	—	96	4
35	T.CD4_Tcm.Tfh_like	12.46	Significant	0.46	1.32	Relevant	102	214
36	THYMO.SP_CD8_naive_stress	12.18	Significant	1.00	0.79	—	1	1
37	T.CD4_Tcm.crosstalk_myeloid	11.96	Significant	1.00	0.67	—	5	4
38	T.CD4_naive.proteostasis	11.87	Significant	0.75	1.30	—	14	9
39	NEU.EXC_CT.Ca2_signaling	11.84	Significant	—	0.02	—	68	17
40	T.CD4_Tcm.baseline	11.78	Significant	0.86	1.00	—	61	31
41	T.CD4_Treg.central_naive_like	11.69	Significant	0.66	1.15	—	333	45
42	T.CD8_Tem.signaling_turnover	11.66	Significant	0.09	1.80	Relevant	425	683
43	T.CD4_Tcm.imprinted_splicing	11.60	Significant	1.00	0.82	Relevant	6	17
44	T.CD8_Tem.TEMRA	11.57	Significant	0.12	1.53	—	920	1,088
45	T.CD8_Tem.motility_primed	11.46	Significant	0.25	1.42	—	269	4
46	T.CD4_Treg.Tr1_like	11.41	Significant	—	0.51	—	8	8
47	T.CD4_naive.resist_bystander	11.30	Significant	0.92	0.96	—	40	25
48	T.CD8_naive.effector_transition	10.99	Significant	0.07	1.78	Relevant	35	62
49	T.CD4_naive.survival_neddylation	10.99	Significant	0.92	1.11	Relevant	26	38
50	T.CD4_Th17.baseline	10.91	Significant	0.54	1.13	—	51	5
51	NK.adaptive_immature_precursor	10.82	Significant	1.08e-03	2.10	—	358	111
52	NK.adaptive_HLAE_tuned	10.77	Significant	4.63e-08	2.43	—	1,124	189
53	T.CD4_naive.mature_mitoprot	10.71	Significant	0.75	1.27	Specific	212	476
54	EPI.ileal_goblet.stress_metallothionein	10.67	Significant	—	1.09	Relevant	4	11
55	T.CD4_naive.neddylation	10.59	Significant	0.75	1.27	Relevant	104	222
56	T.CD4_naive.proteostasis_mitoprot	10.50	Significant	0.92	1.03	Relevant	15	37
57	T.CD4_Tcm.tissue_homing	10.50	Significant	1.00	0.64	—	78	46
58	T.CD4_naive.survival	10.44	Significant	0.92	0.63	Relevant	12	17
59	T.CD4_naive.purinergic	10.40	Significant	0.92	1.02	—	49	1
60	T.CD4_naive.mature	10.32	Significant	0.92	0.85	—	211	100
61	T.CD4_naive.homeostatic	10.26	Significant	0.92	0.82	—	215	108
62	T.CD4_cytotoxic.precursor	10.26	Significant	0.60	1.30	—	156	67
63	T.CD8_Tem.stress_adapted	10.24	Significant	1.00	0.55	—	607	520
64	EC.lymphatic.baseline	10.21	Significant	0.38	1.37	Relevant	38	72
65	EPI.salivary_serous_acinar.secretory_active	10.17	Significant	0.13	1.58	—	242	69
66	T.CD8_Tem.early_helper_like	10.00	Significant	1.00	0.82	Relevant	445	755
67	T.CD4_naive.neddylation_mitoprot	9.94	Significant	0.92	0.71	—	93	56
68	EPI.ileal_goblet.baseline	9.87	Significant	0.59	1.26	—	16	2
69	T.CD8_naive.vesicle_secretory	9.85	Significant	0.76	1.24	—	42	0
70	T.CD4_naive.survival_mitoprot	9.81	Significant	0.92	0.91	—	13	7
71	T.CD4_naive.gut_prone	9.79	Significant	0.92	0.57	—	35	70
72	T.CD4_Tcm.stress	9.77	Significant	1.00	0.49	Relevant	5	11
73	T.CD8_naive.lipid_synthesis	9.75	Significant	0.83	0.87	—	6	4
74	EC.liver_sinusoidal.remodeling_lipotoxicity	9.73	Significant	—	1.65	Specific	90	58
75	NK.adaptive_classII_inhibitory	9.58	Significant	0.11	1.58	—	880	154
76	EPI.renal_principal_cell.injury_repair	9.52	Significant	0.15	1.76	—	26	9
77	NK.adaptive_axis_baseline	9.45	Significant	0.29	1.36	—	1,008	153
78	T.CD8_naive.cytokine_dampened	9.43	Significant	0.83	0.87	—	71	4
79	T.CD4_cytotoxic.NK_adapted	9.41	Significant	0.32	1.63	—	82	33
80	EC.lymphatic.tip_migratory	9.32	Significant	0.53	1.11	Relevant	23	37
81	T.CD8_naive.baseline	9.20	Significant	0.78	1.10	—	142	2
82	NK.cytokine_quiescent	9.20	Significant	0.55	1.25	Relevant	623	1,062
83	EPI.renal_distal_tubule.ion_transport	9.11	Significant	—	1.34	Relevant	0	0
84	NEU.EXC_CT.projector	9.06	Significant	0.96	0.18	Relevant	87	26
85	NK.adaptive_terminal_cytotoxic	9.01	Significant	1.00	0.99	Relevant	485	802
86	T.CD8_Tcm.gut_homing	9.01	Significant	1.00	0.40	—	380	112
87	EPI.salivary_serous_acinar.quiescent	9.00	Significant	0.63	0.89	Relevant	178	493
88	NK.cytokine_vascular_patrolling	8.87	Significant	1.00	0.95	—	863	94
89	CM.inflammatory	8.86	Significant	—	0.00	—	0	0
90	T.CD8_naive.innate_like	8.86	Significant	0.80	1.04	—	10	1
91	T.CD4_cytotoxic.terminal_effector	8.85	Significant	0.79	0.99	—	286	21
92	EPI.ileal_goblet.inflammatory_mucin	8.83	Significant	0.92	0.27	Relevant	6	9
93	T.CD8_Tem.baseline	8.82	Significant	1.00	0.18	—	458	356
94	T.CD4_Treg.APC_interactive	8.81	Significant	0.95	0.93	—	118	28
95	NEU.INH_VIP.cannabinoid	8.74	Significant	—	1.79	Relevant	0	0
96	T.CD4_cytotoxic.activated	8.69	Significant	0.79	0.85	Relevant	3	1
97	T.CD8_naive.mito_proteostasis	8.62	Significant	0.76	1.36	—	428	100
98	MESO.baseline	8.41	Significant	0.35	1.23	Relevant	0	6
99	NK.adaptive_biosynthetic_primed	8.41	Significant	1.00	0.64	Relevant	244	405
100	T.CD4_Tcm.regulatory_poised	8.36	Significant	1.00	0.14	—	2	3
101	NK.cytokine_repair_primed	8.29	Significant	1.00	0.88	—	266	11
102	MG.phagocytic_APC	8.23	Significant	0.48	1.40	—	25	8
103	T.CD4_Tem.transitional_CM	8.21	Significant	0.05	1.53	—	31	20
104	EPI.colonic_tuft.homeostatic	8.18	Significant	—	0.73	—	0	0
105	EC.lymphatic.activated	8.14	Significant	0.96	0.24	Relevant	47	73
106	T.CD8_naive.splicing_enriched	8.08	Significant	1.00	0.28	—	120	16
107	NK.cytokine_axis_baseline	8.05	Significant	1.00	1.00	—	1,172	116
108	NK.cytokine_biosynthetic_primed	7.98	Significant	1.00	0.81	—	360	21
109	NEU.EXC_IT.callosal	7.96	Significant	9.66e-03	1.70	Specific	286	119
110	T.CD4_Th17.cytotoxic	7.92	Significant	0.99	0.23	—	332	123
111	MG.baseline	7.87	Significant	0.94	0.86	—	16	5
112	EPI.renal_principal_cell.activated_acute	7.81	Significant	0.55	1.34	Relevant	29	59
113	T.CD4_Tcm.effector_like	7.81	Significant	1.00	0.11	Relevant	293	533
114	T.CD8_naive.nfkb_related	7.76	Significant	1.00	0.39	—	1	0
115	NEU.EXC_IT.guidance	7.69	Significant	0.15	1.42	Relevant	274	63
116	SKM.type_1_slow.oxidative	7.54	Significant	2.73e-03	2.51	Specific	802	251
117	NK.adaptive_adipose_stress	7.42	Significant	1.00	0.44	—	374	39
118	NEU.INH_PVALB.neuromodulatory	7.40	Significant	—	1.94	Relevant	0	0
119	EC.heart_remodeling.angiocrine	7.26	Significant	6.13e-03	2.12	Specific	182	525
120	T.CD8_Tcm.effector_bias	7.17	Significant	1.00	0.00	Relevant	199	329
121	EPI.pancreatic_islet.delta	7.16	Significant	—	1.64	Relevant	0	0
122	T.CD4_Th2.precursor	7.12	Significant	—	0.48	Relevant	0	0
123	NEU.INH_VIP.develop_niche	7.03	Significant	—	1.68	Relevant	0	0
124	EC.lymphatic.valve	6.86	Significant	—	0.00	Relevant	0	0
125	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	6.70	Significant	6.51e-03	2.18	Specific	449	1,034
126	EC.heart_remodeling.remodeling_secretory	6.68	Significant	0.74	1.24	Relevant	605	1,341
127	MG.expanding	6.60	Significant	0.94	0.37	—	2	1
128	T.CD4_transitional.APC_interacting	6.56	Significant	0.86	1.13	—	10	14
129	T.CD4_cytotoxic.baseline	6.46	Significant	0.95	0.29	—	0	0
130	SKM.type_1_slow.contractile	6.36	Significant	0.98	0.64	—	596	8
131	T.gamma_delta.central_memory	6.18	Significant	0.75	0.95	Relevant	460	919
132	NEU.EXC_IT.adhesion	6.17	Significant	1.00	1.00	Other	252	108
133	T.CD4_Tem.long_term_memory	6.03	Significant	0.58	1.13	Relevant	314	587
134	NEU.INH_PVALB.nuclear_reg	6.00	Significant	0.24	1.59	Relevant	25	12
135	MESO.antiviral	5.88	Significant	—	0.23	Other	3	8
136	EPI.ileal_goblet.immature	5.75	Significant	—	0.00	Relevant	0	0
137	EC.heart_remodeling.activated_acute	5.70	Significant	0.98	0.48	Other	102	186
138	T.gamma_delta.cytotoxic_effector	5.69	Significant	0.75	1.15	Other	349	109
139	EC.heart_remodeling.perivascular	5.63	Significant	0.98	0.48	Relevant	124	408
140	SKM.type_1_slow.glycolytic	5.63	Significant	0.98	0.21	Relevant	362	647
141	EC.liver_sinusoidal.stress	5.60	Significant	—	0.73	Relevant	413	158
142	T.gamma_delta.early_effector	5.59	Significant	0.75	0.78	Other	89	0
143	EPI.endocervical_secretory.secretory_translocon	5.47	Nominal	—	0.67	Relevant	0	0
144	EC.heart_remodeling.remodeling_stalk	5.44	Nominal	0.98	0.34	Other	33	111
145	EPI.colonic_tuft.activated	5.33	Nominal	—	0.00	Other	0	0
146	T.CD4_transitional.baseline	5.31	Nominal	0.91	0.89	Other	59	97
147	T.CD4_transitional.primed_helper_effector	5.30	Nominal	0.69	1.25	Other	19	43
148	EPI.renal_principal_cell.intercalated_like	5.21	Nominal	0.96	0.77	Other	63	66
149	MAC.microglia_like.patrolling_adhesive	5.05	Nominal	—	0.17	Other	0	0
150	T.CD8_transitional.early	4.97	Nominal	0.30	1.19	Other	327	55
151	T.CD4_Tem.cytotoxic_effector	4.95	Nominal	0.61	1.03	Other	225	398
152	T.CD4_transitional.tissue_enagement	4.92	Nominal	0.91	0.91	Other	5	11
153	MAC.microglia_like.inflammatory_chemokine	4.83	Nominal	—	0.08	Other	20	32
154	T.CD4_Tfh.precursor_migratory	4.80	Nominal	0.34	1.16	Other	72	27
155	NEU.INH_PVALB.serotonergic	4.79	Nominal	—	0.00	Other	0	0
156	MAC.kupffer.inflammatory	4.78	Nominal	—	0.00	Other	7	4
157	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	4.77	Nominal	—	0.00	Other	0	0
158	NEU.INH_LAMP5.rosehip	4.71	Nominal	—	0.53	Other	0	0
159	EPI.renal_principal_cell.canonical_vasopressin	4.70	Nominal	0.96	0.33	Other	2	0
160	NEU.INH_PVALB.fastspike	4.61	Nominal	—	0.00	Other	24	22
161	NEU.INH_LAMP5.projecting	4.61	Nominal	—	0.63	Other	0	0
162	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	4.55	Nominal	—	0.00	Other	0	0
163	NEU.INH_LAMP5.glial_interface	4.52	Nominal	—	0.46	Other	0	0
164	NEU.INH_VIP.matrix	4.43	Nominal	—	0.95	Other	24	77
165	NK.cytokine_tissue_activation	4.34	Nominal	1.00	0.11	Other	267	450
166	MESO.secretory_structural	4.30	Nominal	—	0.00	Other	0	0
167	EPI.alveolar_type_1.baseline	4.29	Nominal	0.11	1.66	Other	8	0
168	SKM.type_2_fast.glycolytic_IIx_IIb	4.28	Nominal	0.01	2.23	Other	565	1,482
169	HEP.periportal_metabolic.stress_chaperone	4.19	Nominal	—	1.06	Other	66	128
170	T.CD8_transitional.effector_primed	4.19	Nominal	0.41	1.09	Other	435	151
171	T.CD4_Tfh.effector_migratory	4.16	Nominal	0.34	1.17	Other	122	57
172	NEU.INH_PVALB.metabotropic	4.13	Nominal	—	0.00	Other	0	0
173	T.CD4_Tem.inflammatory	4.11	Nominal	0.97	0.58	Other	28	6
174	EPI.ileal_enterocyte_crypt.secretory_precursor	3.96	Nominal	—	1.53	Other	0	0
175	T.CD8_transitional.Trm_primed	3.91	Nominal	0.41	1.08	Other	108	15
176	NEU.INH_PVALB.chandelier	3.90	Nominal	0.97	0.20	Other	19	16
177	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	3.89	Nominal	—	1.32	Other	0	0
178	EPI.renal_principal_cell.inflammatory	3.80	Nominal	0.96	0.40	Other	74	157
179	EPI.renal_distal_tubule.repair	3.78	Nominal	—	0.14	Other	34	102
180	EC.liver_sinusoidal.hypoxia_metabolic	3.76	Nominal	0.89	0.84	Other	183	107
181	SKM.type_2_fast.oxidative_IIa	3.72	Nominal	1.00	0.00	Other	946	56
182	EPI.renal_intercalated_cell_type_A.PC_transitional	3.60	Nominal	—	1.26	Other	203	407
183	HEP.periportal_metabolic.canonical_urea_cycle	3.60	Nominal	7.41e-03	1.40	Other	1,464	269
184	EC.heart_remodeling.translation_boost	3.58	Nominal	—	0.00	Other	0	0
185	T.MAIT.cytotoxic	3.57	Nominal	0.49	1.29	Other	52	15
186	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	3.52	Nominal	—	0.58	Other	6	9
187	EPI.tracheal_basal.homeostatic_progenitor	3.49	Nominal	0.18	1.62	Other	285	74
188	EPI.colonic_enteroendocrine.progenitor	3.45	Nominal	—	0.97	Other	0	0
189	EPI.ileal_enterocyte_absorptive.brush_border	3.44	Nominal	1.19e-08	2.22	Other	580	1,717
190	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	3.44	Nominal	—	0.00	Other	0	0
191	NEU.EXC_NTNG1.nuclear_reg	3.43	Nominal	—	0.67	Other	0	0
192	MAC.microglia_like.phagocytic_redox	3.40	Nominal	—	0.00	Other	0	0
193	EC.liver_sinusoidal.inflammatory	3.39	Nominal	—	0.00	Other	223	154
194	NEU.EXC_NTNG1.synaptic	3.37	Nominal	—	0.00	Other	0	0
195	NEU.INH_LAMP5.exc_inh_balance	3.31	Nominal	—	0.00	Other	46	2
196	T.CD8_transitional.APC_like	3.31	Nominal	0.94	0.76	Other	205	62
197	EC.heart_remodeling.capillary_metabolic	3.27	Nominal	0.98	0.93	Other	54	414
198	NEU.INH_VIP.LAMP5_hybrid	3.26	Nominal	—	0.68	Other	1	9
199	T.MAIT.vesicle	3.26	Nominal	0.49	1.15	Other	37	65
200	MAC.kupffer.stress	3.22	Nominal	0.63	0.92	Other	9	3
201	EPI.salivary_intercalated_defense.canonical_antimicrobial	3.21	Nominal	0.02	1.43	Other	11	22
202	EPI.colonocyte.goblet_interface	3.15	Nominal	—	2.06	Other	11	21
203	NEU.EXC_IT.transitional	3.09	Nominal	1.00	0.61	Other	237	142
204	ASTRO.immature_lipid	3.08	Nominal	0.26	1.33	Other	23	113
205	T.MAIT.quiescent	3.07	Nominal	0.49	1.20	Other	100	5
206	T.MAIT.early_activation	3.03	Nominal	0.49	1.20	Other	57	4
207	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	2.99	Nonsignificant	—	0.00	Other	0	0
208	MESO.activated_migratory	2.94	Nonsignificant	—	0.00	Other	0	0
209	B.memory.pDC_imprint	2.91	Nonsignificant	0.17	1.45	Other	157	103
210	T.CD4_transitional.primed_cytotoxic	2.90	Nonsignificant	0.93	0.64	Other	28	30
211	HEP.periportal_metabolic.xenobiotic_detox	2.90	Nonsignificant	0.30	1.18	Other	1,440	139
212	T.MAIT.MAPK_brake	2.89	Nonsignificant	0.99	0.68	Other	44	66
213	THYMO.DP_early_stress	2.89	Nonsignificant	—	0.00	Other	0	0
214	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.88	Nonsignificant	—	0.00	Other	0	0
215	EPI.renal_distal_tubule.ciliated_remodelling	2.86	Nonsignificant	—	0.39	Other	0	0
216	EC.liver_sinusoidal.secretory_lipoprotein	2.81	Nonsignificant	0.89	0.51	Other	120	70
217	EPI.pancreatic_islet.alpha	2.69	Nonsignificant	—	0.36	Other	152	330
218	B.naive.baseline	2.53	Nonsignificant	0.18	1.44	Other	10	13
219	EPI.tracheal_basal.activated_stress	2.49	Nonsignificant	1.00	0.00	Other	32	0
220	EPI.extrahepatic_cholangiocyte.barrier_interface	2.48	Nonsignificant	—	0.00	Other	0	0
221	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.48	Nonsignificant	—	0.24	Other	0	0
222	MAC.resident_cardiac.inflammatory_reparative	2.46	Nonsignificant	3.34e-03	1.99	Other	31	96
223	B.naive.receptor_recycle	2.46	Nonsignificant	0.54	1.23	Other	51	0
224	IPSC.mesendo_primed	2.38	Nonsignificant	2.69e-22	1.71	Other	0	0
225	T.CD4_Tfh.suppression_exhaustion	2.38	Nonsignificant	0.34	1.28	Other	0	2
226	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	2.38	Nonsignificant	—	0.00	Other	5	3
227	NEU.EXC_IT.structural	2.33	Nonsignificant	1.00	0.07	Other	171	41
228	EPI.tracheal_suprabasal.secretory_immune	2.27	Nonsignificant	—	0.26	Other	0	0
229	HEP.canalicular_transport.ductular_like_transition	2.26	Nonsignificant	1.97e-04	1.60	Other	400	87
230	EPI.hepatic_ductular_cholangiocyte.polarity	2.26	Nonsignificant	—	0.00	Other	0	0
231	NK.immature_bridge	2.25	Nonsignificant	1.00	0.08	Other	117	122
232	EPI.ileal_enterocyte_crypt.proliferative_S	2.22	Nonsignificant	0.63	1.39	Other	4	2
233	EPI.hepatic_ductular_cholangiocyte.stress	2.22	Nonsignificant	—	0.00	Other	0	0
234	EPI.ileal_enterocyte_crypt.baseline	2.21	Nonsignificant	0.87	0.94	Other	11	6
235	ASTRO.homeostatic	2.13	Nonsignificant	0.34	1.22	Other	200	431
236	HEP.periportal_metabolic.inflammatory_activated	2.11	Nonsignificant	0.93	0.97	Other	712	1,610
237	T.CD4_Trm.stress_adaptive	2.11	Nonsignificant	0.70	1.20	Other	8	22
238	B.memory.baseline	2.10	Nonsignificant	5.16e-04	1.73	Other	472	99
239	THYMO.proliferative_G2M	2.09	Nonsignificant	—	0.00	Other	164	413
240	EPI.renal_thick_ascending_limb.salt_sensing	2.08	Nonsignificant	9.34e-03	1.62	Other	73	103
241	T.CD4_Tfh.canonical_GC_helper	2.06	Nonsignificant	0.94	0.55	Other	1	2
242	B.naive.purinergic	2.03	Nonsignificant	0.06	1.41	Other	384	820
243	EPI.salivary_serous_acinar.seromucous_like	2.01	Nonsignificant	—	0.00	Other	0	0
244	NEU.EXC_IT.neuromodulated	2.00	Nonsignificant	1.00	0.21	Other	176	116
245	B.naive.remodeling	1.99	Nonsignificant	0.65	1.12	Other	135	230
246	T.CD4_Th2.tissue_adapted	1.99	Nonsignificant	—	0.00	Other	0	0
247	NEU.INH_VIP.opioid	1.95	Nonsignificant	—	0.05	Other	50	9
248	T.MAIT.migratory	1.94	Nonsignificant	0.99	0.31	Other	10	1
249	ASTRO.A2_reactive	1.94	Nonsignificant	0.90	1.00	Other	10	37
250	B.germinal_center.DZ_M_phase	1.90	Nonsignificant	—	1.47	Other	0	0
251	ILC2.quiescent	1.90	Nonsignificant	—	0.80	Other	0	0
252	NK.cytokine_lung_immediate_early	1.88	Nonsignificant	1.00	0.02	Other	424	274
253	EC.liver_sinusoidal.prostanoid	1.88	Nonsignificant	—	0.00	Other	11	64
254	MAC.kupffer.tolerogenic	1.86	Nonsignificant	—	0.00	Other	45	49
255	MAC.kupffer.monocyte_like	1.80	Nonsignificant	—	0.00	Other	0	0
256	MESO.activated_stress	1.79	Nonsignificant	—	0.00	Other	0	0
257	HEP.canalicular_transport.injury_stress	1.79	Nonsignificant	9.05e-03	1.38	Other	289	24
258	EPI.tracheal_submucosal_gland.acinar_serous	1.77	Nonsignificant	—	0.73	Other	0	0
259	EPI.colonic_enteroendocrine.Lcell_peptide	1.75	Nonsignificant	—	0.00	Other	0	0
260	CM.contractile_oxphos	1.75	Nonsignificant	1.00	0.00	Other	6	19
261	B.naive.antigen_presenting_ready	1.75	Nonsignificant	0.82	0.92	Other	48	73
262	T.CD8_transitional.stress	1.73	Nonsignificant	—	0.00	Other	24	34
263	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.70	Nonsignificant	—	0.00	Other	19	54
264	ASTRO.synaptic_interaction	1.67	Nonsignificant	0.90	0.99	Other	76	334
265	EPI.tracheal_suprabasal.transitional_wound	1.67	Nonsignificant	—	0.00	Other	16	1
266	MAC.resident_repair.stress_iron	1.66	Nonsignificant	0.17	1.46	Other	48	97
267	B.naive.proteostasis	1.66	Nonsignificant	0.82	0.93	Other	49	69
268	T.CD4_Trm.central_like	1.65	Nonsignificant	0.70	1.23	Other	38	31
269	B.memory.activated	1.61	Nonsignificant	1.00	0.59	Other	105	29
270	B.naive.activated	1.58	Nonsignificant	0.82	0.94	Other	77	127
271	NEU.INH_VIP.canonical_disinhibitory	1.52	Nonsignificant	0.73	0.77	Other	59	38
272	GRNLSA.proliferative_migratory	1.50	Nonsignificant	0.53	1.15	Other	248	292
273	MAC.resident_cardiac.antigen_presenting	1.48	Nonsignificant	0.36	1.25	Other	52	27
274	ASTRO.stress_mito	1.48	Nonsignificant	1.00	0.90	Other	47	110
275	NEU.INH_VIP.excitatory_coupled	1.46	Nonsignificant	—	0.00	Other	13	0
276	IPSC.mesodermal_primed	1.45	Nonsignificant	0.42	1.29	Other	0	0
277	MAC.resident_iron.heme_recycling	1.42	Nonsignificant	—	1.14	Other	30	37
278	MAC.resident_cardiac.phagocytic_homeostasis	1.42	Nonsignificant	0.87	0.64	Other	564	1,221
279	EPI.renal_distal_tubule.stress	1.37	Nonsignificant	—	0.00	Other	0	0
280	EPI.pancreatic_ductal_bicarbonate.inflammatory	1.32	Nonsignificant	0.37	1.38	Other	14	32
281	T.CD4_Trm.baseline	1.30	Nonsignificant	0.70	0.99	Other	31	21
282	EPI.ileal_enterocyte_crypt.bile_transport	1.27	Nonsignificant	0.97	0.19	Other	2	0
283	NEU.INH_VIP.regulatory_remodeling	1.27	Nonsignificant	—	0.00	Other	6	1
284	T.CD4_Trm.metal_stress	1.27	Nonsignificant	0.70	1.14	Other	34	58
285	B.germinal_center.DZ_S_phase	1.26	Nonsignificant	—	0.58	Other	0	0
286	EPI.colonocyte.crypt_progenitor	1.25	Nonsignificant	0.80	1.18	Other	115	265
287	EPI.colonocyte.ionocyte_BEST4	1.24	Nonsignificant	0.80	0.99	Other	103	188
288	EPI.tracheal_submucosal_gland.ductal_luminal	1.24	Nonsignificant	—	0.00	Other	0	0
289	B.memory.migratory	1.20	Nonsignificant	1.00	0.40	Other	123	208
290	EPI.colonocyte.proximal_transport	1.17	Nonsignificant	0.80	0.95	Other	24	12
291	EC.venous.cardiac_structural	1.17	Nonsignificant	0.01	1.65	Other	102	229
292	EPI.colonocyte.secretory_boost	1.14	Nonsignificant	0.80	0.66	Other	98	91
293	EPI.colonocyte.junction_remodeling	1.14	Nonsignificant	0.80	0.66	Other	218	305
294	NK.cytokine_tissue_resident	1.14	Nonsignificant	1.00	5.24e-03	Other	74	82
295	T.CD4_naive.activated_stress	1.11	Nonsignificant	1.00	0.00	Other	339	429
296	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.10	Nonsignificant	—	0.00	Other	0	0
297	B.naive.metabolic	1.10	Nonsignificant	1.00	0.54	Other	50	79
298	MAC.resident_repair.chemokine_angiocrine	1.09	Nonsignificant	0.47	1.13	Other	87	138
299	EPI.renal_thick_ascending_limb.cation_flux	1.08	Nonsignificant	0.55	1.22	Other	57	95
300	T.MAIT.stress	1.08	Nonsignificant	—	0.00	Other	0	0
301	EPI.ileal_enterocyte_crypt.villus_transition	1.06	Nonsignificant	—	0.00	Other	7	10
302	HEP.canalicular_transport.secretory_ERAD_UPR	1.04	Nonsignificant	0.86	0.91	Other	232	28
303	NEU.INH_VIP.enkephalinergic	1.04	Nonsignificant	—	0.00	Other	0	0
304	IPSC.midbrain_primed	1.03	Nonsignificant	0.59	1.16	Other	0	0
305	HEP.canalicular_transport.pericentral_like_hypoxia	1.02	Nonsignificant	0.86	0.93	Other	326	8
306	HEP.canalicular_transport.baseline	1.02	Nonsignificant	0.86	0.98	Other	199	477
307	ASTRO.hypoxia_angiogenic	1.01	Nonsignificant	0.90	1.04	Other	5	18
308	MAC.resident_repair.ECM_stromal_crosstalk	1.01	Nonsignificant	0.49	1.07	Other	95	158
309	T.CD4_Trm.activated	1.00	Nonsignificant	0.70	0.84	Other	32	26
310	NEU.INH_VIP.nuclear_reg	0.95	Nonsignificant	—	0.00	Other	20	4
311	T.CD4_Trm.cytotoxic_effector	0.95	Nonsignificant	0.70	0.92	Other	118	77
312	PC.IgA_muocsal.plasmablast	0.94	Nonsignificant	0.22	1.40	Other	5	4
313	PC.IgA_muocsal.baseline	0.94	Nonsignificant	0.48	1.12	Other	3	5
314	IPSC.stromal_primed	0.92	Nonsignificant	0.59	1.09	Other	0	0
315	MAC.resident_iron.APC_iron_sensing	0.90	Nonsignificant	0.99	1.09	Other	211	114
316	B.germinal_center.LZ_memory_precursor	0.90	Nonsignificant	—	0.00	Other	0	0
317	PC.IgA_muocsal.migratory	0.90	Nonsignificant	0.58	0.99	Other	4	1
318	EPI.salivary_mucous_acinar.baseline	0.90	Nonsignificant	—	—	Other	394	683
319	B.memory.preactivated	0.87	Nonsignificant	0.41	1.16	Other	173	174
320	PC.IgA_muocsal.activated	0.85	Nonsignificant	0.58	0.97	Other	17	8
321	IPSC.axial_identity_primed	0.83	Nonsignificant	1.00	0.95	Other	0	0
322	T.CD4_Treg.tissue_effector	0.81	Nonsignificant	1.00	0.12	Other	16	13
323	EPI.pancreatic_islet.beta	0.80	Nonsignificant	0.97	0.32	Other	42	57
324	B.germinal_center.LZ_selection	0.80	Nonsignificant	—	0.00	Other	0	0
325	HEP.periportal_metabolic.apolipoprotein_secretory	0.80	Nonsignificant	0.93	0.91	Other	43	110
326	THYMO.proliferative_S	0.78	Nonsignificant	1.00	0.15	Other	163	418
327	EPI.ileal_bile_transport.absorptive_xenobiotic	0.78	Nonsignificant	0.25	1.51	Other	11	12
328	EPI.ileal_enterocyte_absorptive.villus_tip	0.78	Nonsignificant	1.00	0.00	Other	4	3
329	B.germinal_center.LZ_survival	0.78	Nonsignificant	—	0.00	Other	0	0
330	B.naive.restrained	0.77	Nonsignificant	1.00	0.40	Other	183	353
331	NEU.INH_VIP.serotonergic	0.77	Nonsignificant	—	0.00	Other	9	2
332	EPI.colonocyte.distal_absorptive	0.76	Nonsignificant	—	0.00	Other	0	0
333	MAC.kupffer.fibrogenic	0.75	Nonsignificant	—	0.00	Other	0	0
334	NEU.EXC_SYT2.synaptic	0.74	Nonsignificant	—	0.48	Other	0	0
335	IPSC.neuroendocrine_primed	0.71	Nonsignificant	—	0.42	Other	0	0
336	EPI.ileal_bile_transport.detox_transcytosis	0.71	Nonsignificant	—	0.00	Other	0	1
337	EPI.renal_intercalated_cell_type_A.acid_secretion	0.68	Nonsignificant	1.00	0.00	Other	12	6
338	T.CD8_Trm.homeostatic	0.67	Nonsignificant	0.30	1.16	Other	42	5
339	EPI.cervical_suprabasal.secretory_vesicle	0.63	Nonsignificant	—	0.42	Other	0	0
340	HEP.periportal_metabolic.stress_checkpoint	0.60	Nonsignificant	1.00	0.44	Other	234	786
341	T.CD8_Trm.cytotoxic	0.59	Nonsignificant	0.07	1.30	Other	165	85
342	PC.IgG_systemic.metabolic	0.58	Nonsignificant	0.56	1.19	Other	46	63
343	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.57	Nonsignificant	—	0.00	Other	10	20
344	HPC.MPP_activated	0.56	Nonsignificant	—	1.16	Other	0	0
345	IPSC.neural_primed	0.55	Nonsignificant	1.00	0.81	Other	0	0
346	MAC.resident_repair.lipid_phagocytic	0.54	Nonsignificant	0.08	1.64	Other	228	604
347	DC.cDC1.baseline	0.54	Nonsignificant	—	1.53	Other	0	0
348	HEP.periportal_metabolic.urea_onecarbon_secretory	0.54	Nonsignificant	0.34	1.14	Other	1,332	3,053
349	EPI.gastric_foveolar.baseline	0.52	Nonsignificant	—	0.00	Other	0	0
350	T.CD8_Trm.muscosal_Tc17	0.52	Nonsignificant	0.06	1.44	Other	19	38
351	T.CD8_Trm.inflammatory	0.49	Nonsignificant	0.64	1.00	Other	124	176
352	MAC.resident_repair.antigen_presenting	0.48	Nonsignificant	0.98	0.50	Other	244	113
353	GRNLSA.EMT_insulin_signaling	0.47	Nonsignificant	0.53	1.14	Other	47	84
354	THYMO.SP_CD8_transitional	0.45	Nonsignificant	1.00	0.21	Other	32	75
355	T.CD4_Trm.helper_like	0.44	Nonsignificant	0.70	1.03	Other	84	147
356	IPSC.mesenchymal_primed	0.42	Nonsignificant	1.00	0.65	Other	0	0
357	HEP.periportal_metabolic.acute_phase_barrier	0.42	Nonsignificant	1.00	0.48	Other	533	138
358	EPI.ectocervical_granular.secretory_apocrine	0.41	Nonsignificant	—	1.15	Other	0	0
359	GRNLSA.secretory_remodeling	0.41	Nonsignificant	0.53	1.13	Other	90	25
360	PC.IgG_systemic.stress	0.40	Nonsignificant	—	0.13	Other	1	5
361	EPI.lung_multiciliated.mature_motile_cilia	0.40	Nonsignificant	—	1.53	Other	0	0
362	MAC.resident_iron.heme_catabolism	0.39	Nonsignificant	0.99	0.87	Other	30	51
363	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.39	Nonsignificant	1.00	0.82	Other	322	317
364	MAC.resident_iron.stress_tolerogenic	0.37	Nonsignificant	—	0.00	Other	0	0
365	PC.IgG_systemic.interacting	0.36	Nonsignificant	0.74	0.77	Other	0	0
366	EPI.alveolar_type_1.activated	0.36	Nonsignificant	—	0.00	Other	0	0
367	HPC.GMP_inflammatory	0.36	Nonsignificant	0.46	1.21	Other	20	10
368	IPSC.stress	0.35	Nonsignificant	1.00	0.62	Other	0	0
369	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.35	Nonsignificant	—	0.00	Other	0	0
370	IPSC.endoderm_primed	0.35	Nonsignificant	1.00	0.81	Other	0	0
371	EPI.renal_intercalated_cell_type_B.baseline	0.33	Nonsignificant	—	0.00	Other	3	1
372	EC.arterial.arteriole_interface	0.33	Nonsignificant	0.53	1.20	Other	31	12
373	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.33	Nonsignificant	—	0.00	Other	0	0
374	PC.IgG_systemic.secretory	0.33	Nonsignificant	0.56	1.12	Other	0	0
375	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.33	Nonsignificant	—	0.00	Other	0	0
376	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.33	Nonsignificant	—	0.73	Other	0	0
377	FIB.reticular.stromal_niche	0.32	Nonsignificant	0.24	1.23	Other	0	0
378	EC.venous.remodeling_stalk	0.32	Nonsignificant	0.32	1.28	Other	559	566
379	ASPC.mesothelial_like	0.31	Nonsignificant	0.29	1.35	Other	143	486
380	ASTRO.stress_acute	0.31	Nonsignificant	1.00	0.57	Other	60	56
381	B.age_associated.naive_transitional	0.31	Nonsignificant	—	1.03	Other	0	0
382	EPI.cervical_suprabasal.inflammatory_repair	0.30	Nonsignificant	—	0.00	Other	0	0
383	MAC.LAM.inflammatory_APC	0.30	Nonsignificant	8.88e-03	1.25	Other	872	165
384	T.CD8_Trm.dendritic_recruiter	0.30	Nonsignificant	0.94	0.60	Other	47	85
385	MAC.MDM.complement_resolving	0.29	Nonsignificant	0.56	1.03	Other	440	860
386	HEP.canalicular_transport.inflammatory	0.29	Nonsignificant	1.00	0.19	Other	1,335	194
387	EPI.salivary_intercalated_defense.inflammatory	0.29	Nonsignificant	1.00	0.13	Other	152	360
388	MAC.MDM.LAM_like	0.28	Nonsignificant	0.30	1.27	Other	12	14
389	EPI.renal_thick_ascending_limb.remodeling	0.28	Nonsignificant	1.00	0.44	Other	152	92
390	FIB.reticular.immune_interface	0.27	Nonsignificant	—	0.55	Other	1	6
391	EC.venous.baseline	0.25	Nonsignificant	0.97	0.89	Other	346	807
392	FIB.adventitial.activated_remodelling	0.23	Nonsignificant	—	2.05	Other	141	319
393	MUSC.activated_migratory	0.23	Nonsignificant	0.10	1.54	Other	6	7
394	ILC2.activated	0.22	Nonsignificant	—	0.00	Other	0	0
395	FIB.skin_sheath.stress_chaperone	0.21	Nonsignificant	—	1.03	Other	0	0
396	EC.venous.activated	0.20	Nonsignificant	0.76	1.00	Other	247	752
397	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.20	Nonsignificant	0.17	1.19	Other	7	16
398	EC.venous.quiescent_homeostatic	0.20	Nonsignificant	0.70	1.08	Other	456	360
399	MAC.MDM.APC_dendritic	0.20	Nonsignificant	0.56	0.99	Other	48	15
400	ASPC.proliferative	0.19	Nonsignificant	0.48	1.28	Other	33	85
401	NEU.EXC_SYT2.nuclear_reg	0.19	Nonsignificant	—	0.00	Other	0	0
402	EPI.pancreatic_ductal_bicarbonate.activated	0.19	Nonsignificant	0.89	0.93	Other	10	7
403	SMC.activated	0.18	Nonsignificant	0.09	1.28	Other	2	5
404	HPC.CLP_B_primed	0.17	Nonsignificant	—	0.77	Other	0	0
405	GRNLSA.lipid_hypoxia	0.17	Nonsignificant	0.69	1.04	Other	28	0
406	EC.arterial.elastic	0.17	Nonsignificant	0.53	1.16	Other	22	45
407	MONO.CD16.hepatic_mac_like	0.17	Nonsignificant	0.17	1.28	Other	803	117
408	IPSC.proliferative	0.17	Nonsignificant	1.00	0.36	Other	0	0
409	FIB.suburothelial.inflammatory_prostanoid	0.16	Nonsignificant	—	1.59	Other	0	0
410	GRANU.MAST.activated_repair	0.16	Nonsignificant	—	0.15	Other	0	1
411	HPC.MPP_IEG	0.15	Nonsignificant	0.86	1.09	Other	45	46
412	GRANU.MAST.activated_acute	0.15	Nonsignificant	—	0.00	Other	0	0
413	EC.arterial.arteriole_gas_exchange	0.15	Nonsignificant	0.53	1.15	Other	238	131
414	EC.arterial.angiogenic_tip	0.14	Nonsignificant	—	0.72	Other	30	37
415	MAC.proliferating.DNA_replication	0.14	Nonsignificant	0.29	1.16	Other	3	6
416	THYMO.DN_preTCR	0.14	Nonsignificant	1.00	0.08	Other	41	71
417	MAC.resident_iron.redox_metabolic	0.13	Nonsignificant	0.99	0.36	Other	4	4
418	DC.cDC2.migratory	0.13	Nonsignificant	0.10	1.19	Other	185	39
419	DC.cDC2.monocyte_like	0.13	Nonsignificant	0.10	1.20	Other	1,285	791
420	EPI.ectocervical_granular.inflammatory	0.12	Nonsignificant	—	0.32	Other	0	0
421	HEP.acute_phase.complement_metabolic	0.12	Nonsignificant	0.10	1.17	Other	1,423	3,464
422	FIB.neurolectin_mucosa.axon_responsive	0.12	Nonsignificant	0.48	1.26	Other	10	10
423	EC.arterial.inflammatory	0.12	Nonsignificant	0.65	1.08	Other	63	50
424	MONO.CD16.baseline	0.11	Nonsignificant	0.17	1.32	Other	50	1
425	MAC.LAM.lipid_phagocytosis	0.11	Nonsignificant	0.99	0.87	Other	369	328
426	MAC.LAM.lipid_opsonization	0.11	Nonsignificant	0.99	0.97	Other	45	14
427	FIB.skin_sheath.neuro_vascular_interface	0.11	Nonsignificant	—	0.00	Other	0	0
428	MAC.MDM.inflammatory_phagocytic	0.11	Nonsignificant	0.56	1.05	Other	199	52
429	GRANU.MAST.resting_granule	0.10	Nonsignificant	—	0.00	Other	0	0
430	EPI.pancreatic_ductal_bicarbonate.baseline	0.10	Nonsignificant	0.89	0.89	Other	11	42
431	GRNLSA.angiocrine_mechanosensory	0.10	Nonsignificant	—	0.35	Other	0	0
432	FIB.skin_sheath.ECM_immune	0.10	Nonsignificant	—	0.00	Other	0	0
433	EPI.thymic_medullary.canonical_alarmin	0.10	Nonsignificant	0.23	1.34	Other	8	17
434	FIB.suburothelial.contractile_myofibroblast	0.10	Nonsignificant	—	0.73	Other	9	0
435	EPI.renal_distal_tubule.immune_modulatory	0.09	Nonsignificant	—	0.00	Other	0	0
436	DC.cDC2.adhesion_signaling	0.09	Nonsignificant	0.85	1.03	Other	35	9
437	FIB.barrier_purinergic.lipid_secretory	0.09	Nonsignificant	—	0.48	Other	0	0
438	MONO.CD16.inflammatory	0.09	Nonsignificant	0.54	1.07	Other	1,640	168
439	FIB.neurolectin_mucosa.remodeling_repair	0.09	Nonsignificant	—	0.11	Other	4	2
440	EPI.salivary_duct_excretory.baseline	0.09	Nonsignificant	0.08	1.31	Other	23	57
441	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.09	Nonsignificant	—	0.21	Other	0	0
442	MONO.CD14.cord_tolerance	0.09	Nonsignificant	0.62	1.10	Other	864	753
443	FIB.neurolectin_mucosa.nerve_interface	0.08	Nonsignificant	—	0.00	Other	4	0
444	EC.capillary.angiogenic_tip	0.08	Nonsignificant	0.66	1.18	Other	186	218
445	ASTRO.A1_reactive	0.08	Nonsignificant	1.00	0.36	Other	433	394
446	HEP.acute_phase.hypoxia_lipid	0.08	Nonsignificant	—	0.96	Other	0	0
447	B.age_associated.migratory	0.08	Nonsignificant	0.58	1.01	Other	2	2
448	HEP.acute_phase.proliferative	0.08	Nonsignificant	—	0.00	Other	4	6
449	CHOND.articular_collagen	0.07	Nonsignificant	0.04	1.12	Other	551	266
450	EC.arterial.ion_pump	0.07	Nonsignificant	0.88	0.98	Other	3	2
451	MUSC.baseline	0.07	Nonsignificant	0.94	0.91	Other	0	0
452	MONO.CD14.APC_like	0.07	Nonsignificant	6.51e-04	1.21	Other	1,686	2,493
453	EPI.renal_immature_ureteric_bud.defense_secretory	0.07	Nonsignificant	0.15	1.38	Other	45	76
454	EPI.renal_thick_ascending_limb.barrier_repair	0.07	Nonsignificant	1.00	0.00	Other	141	284
455	FIB.neurolectin_mucosa.inflammatory	0.07	Nonsignificant	0.68	0.86	Other	52	110
456	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.07	Nonsignificant	0.58	1.23	Other	40	191
457	ASPC.stem_like_progenitor	0.07	Nonsignificant	0.83	1.09	Other	300	842
458	GRNLSA.chemokine_mechanosensory	0.06	Nonsignificant	0.82	0.92	Other	1	0
459	MEL.neurotrophic_migratory	0.06	Nonsignificant	—	1.27	Other	0	0
460	MUSC.quiescent_reservoir	0.06	Nonsignificant	0.94	0.77	Other	2	8
461	EPI.thymic_medullary.hormone_xeno_barrier	0.06	Nonsignificant	—	0.00	Other	0	8
462	FIB.reticular.stress_metallothionein	0.06	Nonsignificant	—	0.00	Other	3	32
463	HPC.LMPP	0.06	Nonsignificant	0.99	0.74	Other	65	31
464	EC.venous.adipose_lipid	0.06	Nonsignificant	0.97	0.60	Other	254	476
465	MEL.dedifferentiated_migratory	0.06	Nonsignificant	—	1.10	Other	0	0
466	EC.capillary.activated	0.06	Nonsignificant	0.66	1.20	Other	2	5
467	FIB.perivascular_interface.vasomotor_tone	0.05	Nonsignificant	—	0.32	Other	0	0
468	CHOND.remodeling	0.05	Nonsignificant	—	0.48	Other	5	0
469	SMC.contractile	0.05	Nonsignificant	0.84	0.99	Other	80	588
470	EC.arterial.homeostatic	0.05	Nonsignificant	0.97	0.71	Other	24	3
471	GRNLSA.stress_metabolic	0.05	Nonsignificant	—	0.08	Other	1	2
472	FIB.suburothelial.urothelial_interface	0.05	Nonsignificant	0.90	0.44	Other	9	8
473	FIB.perivascular_interface.vascular_BM_remodelling	0.05	Nonsignificant	—	0.64	Other	0	0
474	MONO.CD16.patrolling	0.04	Nonsignificant	1.00	0.55	Other	797	216
475	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	0.04	Nonsignificant	—	0.00	Other	49	237
476	ILC2.migratory	0.04	Nonsignificant	—	0.00	Other	0	0
477	FIB.suburothelial.homeostasis_matrix	0.04	Nonsignificant	0.90	0.44	Other	258	921
478	FIB.barrier_secretory.homeostasis	0.04	Nonsignificant	—	0.17	Other	0	0
479	GRNLSA.p53_damage	0.04	Nonsignificant	—	0.00	Other	13	10
480	MAC.LAM.antimicrobial	0.04	Nonsignificant	0.99	0.64	Other	389	93
481	EC.arterial.mito_contact	0.04	Nonsignificant	0.97	0.65	Other	14	5
482	PLAT.adhesion	0.03	Nonsignificant	—	0.48	Other	0	0
483	OLG.myelinating_mature	0.03	Nonsignificant	4.17e-04	1.14	Other	363	94
484	EPI.ectocervical_granular.immune_interact	0.03	Nonsignificant	—	0.00	Other	0	0
485	FIB.adventitial.adhesion_lipid	0.03	Nonsignificant	1.00	1.07	Other	58	209
486	FIB.hepatic_stellate_cell.fibrogenic	0.03	Nonsignificant	—	0.73	Other	0	0
487	EPI.pancreatic_ductal_perivascular.baseline	0.03	Nonsignificant	0.30	1.24	Other	1	5
488	FIB.barrier_secretory.remodeling	0.03	Nonsignificant	—	0.00	Other	0	0
489	DC.cDC2.antiviral	0.03	Nonsignificant	1.00	0.91	Other	100	37
490	FIB.adventitial.inflammatory_activated	0.03	Nonsignificant	0.53	1.15	Other	100	473
491	EPI.pancreatic_acinar.inflammatory_regenerative	0.03	Nonsignificant	0.58	1.33	Other	25	113
492	EPI.esophageal_basal.activated_progenitor	0.03	Nonsignificant	0.21	1.49	Other	1	0
493	MAC.LAM.perivascular_angiocrine	0.03	Nonsignificant	—	0.00	Other	53	138
494	MAC.LAM.anti_inflammatory	0.03	Nonsignificant	0.99	0.54	Other	86	132
495	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.03	Nonsignificant	—	0.00	Other	0	0
496	FIB.skin_neurosecretory.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
497	DC.mig.baseline	0.03	Nonsignificant	—	0.00	Other	1	0
498	EC.arterial.metabolic	0.03	Nonsignificant	0.97	0.68	Other	195	159
499	HEP.acute_phase.baseline	0.03	Nonsignificant	1.00	0.84	Other	946	19
500	SMC.metabolic	0.03	Nonsignificant	0.92	0.78	Other	14	40
501	EPI.salivary_myoepithelial.contractile_repair	0.03	Nonsignificant	—	1.80	Other	3	9
502	MAC.proliferating.stress	0.02	Nonsignificant	—	0.00	Other	87	136
503	EC.capillary.inflammatory	0.02	Nonsignificant	0.79	1.00	Other	27	51
504	EPI.skin_keratinocyte_progenitor.activated_stress	0.02	Nonsignificant	—	0.38	Other	0	0
505	EPI.thymic_medullary.stress_APC	0.02	Nonsignificant	0.97	0.34	Other	2	4
506	EPI.thymic_cortical.secretory_remodeling	0.02	Nonsignificant	—	0.78	Other	4	1
507	EPI.skin_keratinocyte_basal.spinous_transition	0.02	Nonsignificant	—	0.97	Other	0	0
508	ASPC.inflammatory	0.02	Nonsignificant	0.83	1.02	Other	21	61
509	FIB.hepatic_stellate_cell.contractile	0.02	Nonsignificant	—	0.00	Other	0	0
510	OLG.myelinating_stress	0.02	Nonsignificant	1.00	1.00	Other	232	62
511	FIB.skin_tenogenic.baseline	0.02	Nonsignificant	—	0.00	Other	0	2
512	ASPC.adipocyte_capillary_interface	0.02	Nonsignificant	0.83	1.07	Other	21	54
513	EC.capillary.postcap_venule	0.02	Nonsignificant	0.66	1.06	Other	355	261
514	ASPC.secretory	0.02	Nonsignificant	0.83	1.00	Other	76	5
515	B.age_associated.activated	0.02	Nonsignificant	—	0.00	Other	18	22
516	HEP.acute_phase.inflammatory	0.02	Nonsignificant	1.00	0.85	Other	382	649
517	OLG.regulatory_activated	0.02	Nonsignificant	4.17e-04	1.26	Other	196	614
518	ASPC.niche_keeping_progenitor	0.02	Nonsignificant	0.83	0.94	Other	52	219
519	MEL.secretory_quiescent	0.02	Nonsignificant	0.98	1.03	Other	19	13
520	ASTRO.neuromodulatory	0.02	Nonsignificant	1.00	0.25	Other	34	172
521	MUSC.early_activation	0.02	Nonsignificant	0.94	0.26	Other	4	32
522	EPI.pancreatic_acinar.stress	0.02	Nonsignificant	0.58	1.26	Other	28	28
523	EC.capillary.baseline	0.02	Nonsignificant	0.79	0.98	Other	246	560
524	EPI.lung_multiciliated.baseline	0.02	Nonsignificant	—	0.51	Other	0	7
525	MONO.CD16.platelet_bound	0.02	Nonsignificant	1.00	0.42	Other	372	508
526	FIB.interstitial.lipid_matrix	0.02	Nonsignificant	0.83	1.04	Other	258	191
527	FIB.lung_alveolar.stress_interacting	0.02	Nonsignificant	—	0.97	Other	0	0
528	EPI.alveolar_type_2.baseline_surfactant	0.02	Nonsignificant	0.34	1.21	Other	64	9
529	EC.capillary.stress	0.02	Nonsignificant	0.79	0.96	Other	44	36
530	FIB.interstitial.immune_interact	0.02	Nonsignificant	0.32	1.26	Other	12	1
531	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.02	Nonsignificant	8.70e-04	2.12	Other	58	89
532	EPI.lung_club_secretory.canonical_surfactant	0.02	Nonsignificant	—	0.87	Other	74	104
533	FIB.tracheal_subepithelial.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
534	MONO.CD14.platelet_bound	0.01	Nonsignificant	0.83	1.05	Other	964	176
535	EPI.renal_immature_ureteric_bud.osmoprotective	0.01	Nonsignificant	0.75	0.95	Other	126	44
536	FIB.skin_papillary.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
537	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.01	Nonsignificant	1.00	0.30	Other	219	533
538	PERI.inflammatory	0.01	Nonsignificant	0.13	1.27	Other	40	77
539	FIB.interstitial.remodeling	0.01	Nonsignificant	0.83	1.08	Other	31	9
540	FIB.interstitial.mesenchymal_regulator	0.01	Nonsignificant	1.00	0.90	Other	4	4
541	EPI.salivary_duct_excretory.stress	0.01	Nonsignificant	0.89	0.42	Other	33	68
542	EPI.esophageal_basal.junctional_barrier	0.01	Nonsignificant	—	0.00	Other	0	0
543	SCHWN.axon_contact_cardiac	0.01	Nonsignificant	0.16	1.32	Other	18	63
544	MONO.CD14.remodeling	0.01	Nonsignificant	1.00	0.88	Other	2,373	295
545	PLAT.megakaryocytic	0.01	Nonsignificant	—	0.00	Other	0	0
546	FIB.perivascular_interface.lipid_shuttle	0.01	Nonsignificant	—	0.00	Other	51	170
547	EPI.thymic_medullary.proliferative_APC	0.01	Nonsignificant	—	0.00	Other	0	0
548	SCHWN.reactive_inflammatory	0.01	Nonsignificant	—	0.35	Other	0	0
549	FIB.transitioning.secretory_procollagen	0.01	Nonsignificant	—	0.85	Other	0	0
550	FIB.hepatic_stellate_cell.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
551	ASPC.baseline	0.01	Nonsignificant	0.83	0.96	Other	363	170
552	DC.cDC2.tolerogenic_regulatory	0.01	Nonsignificant	1.00	0.61	Other	44	4
553	PERI.baseline	0.01	Nonsignificant	0.14	1.24	Other	39	66
554	ASPC.remodeling	9.96e-03	Nonsignificant	0.83	0.92	Other	106	354
555	EPI.skin_sweat_duct_keratinocyte.barrier	9.82e-03	Nonsignificant	—	1.13	Other	0	0
556	ASPC.preadipocyte_lipid_primed	9.76e-03	Nonsignificant	0.83	1.01	Other	331	129
557	MONO.CD14.baseline	9.62e-03	Nonsignificant	1.00	0.79	Other	2,268	76
558	DC.cDC2.lipid_metabolic	9.15e-03	Nonsignificant	—	0.00	Other	0	0
559	EPI.skin_interfollicular_spinous.stress_oxidative	8.88e-03	Nonsignificant	—	1.13	Other	0	0
560	OLG.stress	8.83e-03	Nonsignificant	1.00	0.94	Other	232	8
561	EPI.skin_keratinocyte_basal.transit_amplifying	7.65e-03	Nonsignificant	—	0.00	Other	0	0
562	FIB.transitioning.ISG_primed_interface	7.62e-03	Nonsignificant	—	0.05	Other	17	80
563	EPI.lung_multiciliated.stress	7.43e-03	Nonsignificant	—	0.00	Other	67	165
564	EPI.pancreatic_ductal_bicarbonate.stress	7.34e-03	Nonsignificant	—	0.00	Other	12	33
565	EPI.skin_interfollicular_spinous.upper_lipid	6.59e-03	Nonsignificant	—	0.62	Other	6	6
566	HPC.MEP	6.57e-03	Nonsignificant	0.99	0.42	Other	599	1,195
567	IPSC.canonical_pluripotent	6.14e-03	Nonsignificant	1.00	7.16e-03	Other	0	0
568	HEP.pericentral_lipoprotein.ApoB_coagulation	6.06e-03	Nonsignificant	—	0.67	Other	0	0
569	EPI.ectocervical_granular.proliferative_basal	5.84e-03	Nonsignificant	—	0.00	Other	0	0
570	FIB.adventitial.PI16_matrix	5.51e-03	Nonsignificant	1.00	0.84	Other	70	90
571	SCHWN.translation_boost	5.46e-03	Nonsignificant	—	0.00	Other	8	1
572	HEP.pericentral_lipoprotein.UPR_redox	5.45e-03	Nonsignificant	—	0.00	Other	0	0
573	ASPC.activated	5.21e-03	Nonsignificant	0.83	0.99	Other	164	162
574	OLG.vesicle_trafficking	5.14e-03	Nonsignificant	1.00	0.86	Other	124	10
575	HPC.GMP_granulocytic	4.95e-03	Nonsignificant	—	0.00	Other	3	3
576	FIB.adventitial.baseline	4.74e-03	Nonsignificant	1.00	0.82	Other	157	278
577	EPI.skin_follicular_keratinizing.root_infundibulum	4.69e-03	Nonsignificant	—	0.49	Other	0	0
578	FIB.reticular.ECM_builder	4.66e-03	Nonsignificant	—	0.00	Other	0	0
579	EPI.renal_proximal_tubule.detox_antioxidant	4.60e-03	Nonsignificant	1.00	0.00	Other	394	77
580	PERI.cardiac_skeletal	4.56e-03	Nonsignificant	0.97	0.76	Other	313	630
581	EPI.pancreatic_ductal_perivascular.protective_antioxidant	4.23e-03	Nonsignificant	—	0.00	Other	11	69
582	FIB.interstitial.mesenchymal_APC	3.81e-03	Nonsignificant	1.00	0.36	Other	81	33
583	EPI.skin_interfollicular_spinous.baseline	3.75e-03	Nonsignificant	0.99	1.16	Other	35	3
584	EPI.bile_duct_cholangiocyte.inflammatory_APC	3.61e-03	Nonsignificant	—	0.46	Other	2	0
585	GRANU.neutrophil.antiviral_endotoxin	3.34e-03	Nonsignificant	—	0.00	Other	0	0
586	CHOND.angiogenic	3.20e-03	Nonsignificant	—	0.78	Other	0	0
587	EC.capillary.migratory	3.15e-03	Nonsignificant	0.79	0.95	Other	181	509
588	EC.capillary.angiocrine	3.06e-03	Nonsignificant	1.00	0.66	Other	250	630
589	EPI.skin_interfollicular_spinous.stress_UPR	2.97e-03	Nonsignificant	—	0.62	Other	0	0
590	EPI.skin_follicular_keratinizing.transit_amplifying	2.87e-03	Nonsignificant	—	0.56	Other	21	49
591	HEP.acute_phase.stress_secretory	2.69e-03	Nonsignificant	1.00	0.72	Other	26	3
592	EPI.skin_hair_follicle_bulge.quiescent	2.55e-03	Nonsignificant	0.23	1.22	Other	56	69
593	EPI.pancreatic_acinar.metabolic_onecarbon	2.55e-03	Nonsignificant	0.85	1.07	Other	287	328
594	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.51e-03	Nonsignificant	—	1.65	Other	0	0
595	FIB.interstitial.stress_secretory	2.50e-03	Nonsignificant	1.00	0.41	Other	92	56
596	DC.cDC2.pro_inflammatory	2.46e-03	Nonsignificant	1.00	0.49	Other	3	5
597	EPI.salivary_duct_ion_transport.baseline	2.42e-03	Nonsignificant	—	—	Other	0	0
598	FIB.transitioning.motility_remodelling	2.36e-03	Nonsignificant	—	0.00	Other	0	0
599	PERI.angiocrine	2.24e-03	Nonsignificant	0.97	0.78	Other	93	102
600	CHOND.activated_fibro_like	2.16e-03	Nonsignificant	1.00	0.80	Other	531	188
601	MONO.CD14.repair_M2_like	2.12e-03	Nonsignificant	1.00	0.85	Other	550	1,495
602	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	2.04e-03	Nonsignificant	0.13	1.33	Other	2	9
603	EPI.skin_interfollicular_spinous.early_differentiation	2.03e-03	Nonsignificant	0.99	0.89	Other	89	19
604	EPI.endocervical_secretory.squamous_barrier	2.01e-03	Nonsignificant	—	0.00	Other	0	0
605	GRANU.neutrophil.primed_degranulation	2.00e-03	Nonsignificant	—	0.26	Other	0	0
606	FIB.adventitial.mito_secretory	1.84e-03	Nonsignificant	1.00	0.77	Other	21	7
607	MONO.CD14.inflammatory	1.74e-03	Nonsignificant	1.00	0.78	Other	92	134
608	DC.cDC1.cross_presenting	1.69e-03	Nonsignificant	—	0.36	Other	0	0
609	OLG.regulatory	1.64e-03	Nonsignificant	1.00	0.97	Other	353	73
610	EPI.lung_club_secretory.ciliogenesis_primed	1.62e-03	Nonsignificant	—	0.00	Other	0	0
611	FIB.lung_alveolar.mito_secretory	1.39e-03	Nonsignificant	—	0.00	Other	0	0
612	EPI.salivary_myoepithelial.baseline	1.26e-03	Nonsignificant	1.00	1.00	Other	42	141
613	FIB.adventitial.complement_angiocrine	1.26e-03	Nonsignificant	1.00	0.50	Other	153	684
614	EPI.esophageal_suprabasal.differentiating_keratin	1.25e-03	Nonsignificant	0.15	1.31	Other	131	61
615	EPI.bile_duct_cholangiocyte.secretory_mucin	1.25e-03	Nonsignificant	—	0.00	Other	7	12
616	FIB.transitioning.matrix_stress	1.19e-03	Nonsignificant	—	0.00	Other	47	138
617	EPI.esophageal_suprabasal.basal_transitional	1.15e-03	Nonsignificant	0.46	1.12	Other	44	67
618	FIB.adventitial.mechano_chemo_sensing	1.13e-03	Nonsignificant	1.00	0.67	Other	135	524
619	ADIPO.thermogenic	1.07e-03	Nonsignificant	—	1.28	Other	0	0
620	EPI.skin_interfollicular_spinous.inflammatory	8.90e-04	Nonsignificant	—	0.00	Other	0	0
621	EPI.lung_club_secretory.ciliogenesis_axoneme	8.77e-04	Nonsignificant	—	0.00	Other	0	0
622	EPI.pancreatic_ductal_progenitor.ciliated_transport	7.61e-04	Nonsignificant	—	0.03	Other	105	368
623	DC.cDC1.activated	7.39e-04	Nonsignificant	—	0.00	Other	0	0
624	EPI.pancreatic_ductal_progenitor.baseline	7.23e-04	Nonsignificant	0.90	0.61	Other	179	702
625	MEL.stress_glucocorticoid	7.15e-04	Nonsignificant	0.98	0.54	Other	11	34
626	MEL.mature_oxidative_traffic	6.90e-04	Nonsignificant	0.98	0.45	Other	247	285
627	FIB.barrier_purinergic.stress_GF_binding	6.87e-04	Nonsignificant	—	0.00	Other	0	0
628	EPI.skin_sweat_duct_keratinocyte.repair	6.54e-04	Nonsignificant	—	1.08	Other	0	0
629	EPI.salivary_myoepithelial.activated	6.33e-04	Nonsignificant	1.00	0.63	Other	85	281
630	GRANU.neutrophil.tissue_patrolling	5.39e-04	Nonsignificant	—	0.00	Other	0	0
631	EPI.skin_interfollicular_spinous.transition_basal	5.26e-04	Nonsignificant	0.99	0.30	Other	100	127
632	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	4.47e-04	Nonsignificant	—	0.47	Other	0	0
633	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	4.22e-04	Nonsignificant	—	0.67	Other	0	0
634	EPI.skin_hair_follicle_bulge.niche_crosstalk	4.21e-04	Nonsignificant	—	0.00	Other	29	88
635	EPI.skin_interfollicular_spinous.proliferative	3.97e-04	Nonsignificant	—	0.00	Other	0	0
636	EPI.salivary_intercalated_defense.basal_EMT	3.69e-04	Nonsignificant	—	0.00	Other	0	0
637	EPI.pancreatic_ductal_progenitor.ADM_like	3.36e-04	Nonsignificant	—	0.00	Other	0	0
638	DC.cDC1.proliferative	3.04e-04	Nonsignificant	—	0.16	Other	0	0
639	EPI.skin_follicular_keratinizing.upper_infundibulum	2.99e-04	Nonsignificant	—	0.00	Other	8	2
640	DC.cDC2.proliferative	2.86e-04	Nonsignificant	—	0.00	Other	39	71
641	EPI.skin_keratinocyte_proliferating.early_spinous_transition	2.49e-04	Nonsignificant	—	0.87	Other	135	290
642	EPI.skin_appendage_keratinocyte.transit_amplifying	2.48e-04	Nonsignificant	—	0.19	Other	109	358
643	MAC.alveolar.capillary_interacting	2.36e-04	Nonsignificant	0.54	1.35	Other	113	181
644	EPI.alveolar_type_2.injury_primed	2.16e-04	Nonsignificant	0.99	0.82	Other	434	245
645	OLG.reactive_repair	1.89e-04	Nonsignificant	1.00	0.41	Other	385	385
646	EPI.alveolar_type_2.stress_response	1.69e-04	Nonsignificant	0.99	0.60	Other	675	1,562
647	GRNLSA.cholesterol_mevalonate	1.65e-04	Nonsignificant	1.00	0.29	Other	9	4
648	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.50e-04	Nonsignificant	—	0.00	Other	0	0
649	EPI.esophageal_suprabasal.proliferative_exit	1.48e-04	Nonsignificant	—	0.00	Other	0	0
650	EPI.esophageal_suprabasal.proliferative_S	1.36e-04	Nonsignificant	—	0.00	Other	26	41
651	ADIPO.hypoxia_remodelling	1.19e-04	Nonsignificant	—	0.00	Other	29	105
652	EPI.skin_hair_follicle_bulge.anagen_growth	9.99e-05	Nonsignificant	—	0.00	Other	0	0
653	EPI.lung_club_secretory.inflammatory	8.28e-05	Nonsignificant	—	0.00	Other	0	0
654	DC.pDC.immature_metabolic	7.58e-05	Nonsignificant	0.77	1.15	Other	78	124
655	MAC.alveolar.inflammatory	7.21e-05	Nonsignificant	0.54	1.17	Other	208	312
656	EPI.thymic_cortical.Notch_interface	6.38e-05	Nonsignificant	—	0.35	Other	82	137
657	CHOND.pro_inflammatory	6.19e-05	Nonsignificant	1.00	0.54	Other	181	351
658	EPI.salivary_myoepithelial.junctional_transport	5.04e-05	Nonsignificant	1.00	0.22	Other	66	121
659	EPI.pancreatic_acinar.adhesion_remodeling	4.92e-05	Nonsignificant	1.00	0.80	Other	210	784
660	EPI.skin_sebaceous_duct_luminal.detox_repair	4.27e-05	Nonsignificant	0.97	0.44	Other	137	94
661	ASPC.signal_integrator	4.07e-05	Nonsignificant	—	0.00	Other	0	0
662	EPI.thymic_cortical.baseline	3.90e-05	Nonsignificant	0.97	0.03	Other	185	386
663	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	3.67e-05	Nonsignificant	—	0.18	Other	0	0
664	MAC.alveolar.stress_metabolic	3.00e-05	Nonsignificant	0.81	0.98	Other	116	148
665	HEP.acute_phase.complement_antiviral	2.96e-05	Nonsignificant	1.00	0.26	Other	377	751
666	EPI.pancreatic_acinar.baseline	2.30e-05	Nonsignificant	1.00	0.60	Other	274	163
667	EPI.esophageal_suprabasal.proliferative_G2M	1.80e-05	Nonsignificant	—	0.00	Other	0	0
668	EPI.skin_hair_follicle_companion.activated_migratory	1.76e-05	Nonsignificant	—	0.97	Other	0	0
669	EPI.skin_keratinocyte_proliferating.anchor_remodel	1.75e-05	Nonsignificant	—	0.00	Other	0	0
670	DC.pDC.baseline	1.41e-05	Nonsignificant	0.77	1.09	Other	88	123
671	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.40e-05	Nonsignificant	0.99	0.30	Other	33	34
672	ADIPO.immature	1.36e-05	Nonsignificant	—	0.00	Other	24	40
673	MAC.alveolar.biosynthetic_sterol_heme	1.25e-05	Nonsignificant	0.90	0.61	Other	347	40
674	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	9.50e-06	Nonsignificant	—	0.00	Other	0	0
675	MAC.alveolar.lipid_autophagy	9.18e-06	Nonsignificant	—	0.00	Other	35	44
676	EPI.skin_sweat_duct_keratinocyte.proliferative_S	7.88e-06	Nonsignificant	—	0.00	Other	0	0
677	MAC.alveolar.scavenging_endocytic	6.22e-06	Nonsignificant	—	0.00	Other	140	283
678	EPI.skin_keratinocyte_basal.basement_anchoring	5.23e-06	Nonsignificant	—	0.00	Other	0	0
679	EPI.skin_hair_follicle_companion.gap_junction_contractile	5.00e-06	Nonsignificant	—	0.00	Other	0	0
680	EPI.skin_sebaceous_duct_luminal.immune_interface	3.66e-06	Nonsignificant	—	0.00	Other	0	0
681	EPI.skin_sweat_duct_keratinocyte.signal_gate	3.54e-06	Nonsignificant	—	0.00	Other	43	26
682	EPI.pancreatic_acinar.quiet_dedifferentiation	3.26e-06	Nonsignificant	1.00	0.24	Other	142	171
683	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	6.10e-07	Nonsignificant	—	0.00	Other	39	82
684	DC.cDC1.homeostatic_inhibitory	5.74e-07	Nonsignificant	—	0.00	Other	0	0
685	DC.pDC.poised_migratory	8.28e-08	Nonsignificant	0.77	0.84	Other	54	95
686	ADIPO.inflammatory	3.08e-08	Nonsignificant	—	0.00	Other	0	0
687	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	2.60e-08	Nonsignificant	—	0.00	Other	0	0
688	EPI.skin_keratinocyte_proliferating.detox_repair	1.40e-09	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

10 unique genes. Showing 1–10. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ST6GAL1	02-Medium	0.63	17.16	G1	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2), EPI.renal_principal_cell.canonical_vasopressin (L2), THYMO.SP_CD4_naive (L2)	EC.heart_remodeling (Tier: specific) T.CD8_Tem (Tier: specific) EC.heart_remodeling.angiocrine (Tier: specific) T.CD8_Tcm.helper_like (Tier: specific) microglia (Tier: relevant) EPI.renal_principal_cell (Tier: relevant) EC.heart_remodeling.perivascular (Tier: relevant) EC.heart_remodeling.remodeling_secretory (Tier: relevant) EC.liver_sinusoidal.stress (Tier: relevant) EPI.endocervical_secretory.secretory_translocon (Tier: relevant) EPI.renal_principal_cell.activated_acute (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	72 cells — complete matches	105	163
ABO	02-Medium	0.53	4.46	G1	C2	—	EC.heart_remodeling (Tier: specific) NEU.EXC_CT (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD8_Tcm (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) T.CD8_Tcm.helper_like (Tier: specific) EC.lymphatic.activated (Tier: relevant) EC.lymphatic.baseline (Tier: relevant) EC.lymphatic.scavenger (Tier: relevant) EC.lymphatic.valve (Tier: relevant) MESO.baseline (Tier: relevant) NEU.EXC_CT.projector (Tier: relevant) T.CD4_Tem.long_term_memory (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant)	55 cells — complete matches	185	251
ENSG00000289971	02-Medium	0.46	19.26	G2	C1	—	—	—	62	116
ENSG00000286445	02-Medium	0.45	7.01	G1	C2	—	—	—	7	19
MINPP1	02-Medium	0.44	4.77	G1	C2	HPC.MEP (L2)	—	10 cells — complete matches	9	20
ENSG00000305816	02-Medium	0.43	4.86	G1	C2	—	—	—	12	23
OBP2B	02-Medium	0.40	4.32	G1	C2	—	—	—	106	149
ADIPOQ	02-Medium	0.38	13.26	G2	C1	adipocyte (L1), ADIPO.adipocyte (L1S)	—	6 cells — complete matches	6	5
RPL39L	02-Medium	0.33	10.80	G2	C1	—	T.CD8_Tcm (Tier: specific) EC.lymphatic.activated (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	25 cells — complete matches	2	2
LINC02043	02-Medium	0.32	10.33	G2	C1	—	EC.heart_remodeling (Tier: specific) EC.heart_remodeling.angiocrine (Tier: specific)	4 cells — complete matches	57	110

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.