Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90042226 · All tissues

Treatment or medication use - insulin product (UKB data field 20003_1140883066): evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Medication, insulin therapy

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	13.37	Significant	5.95e-43	1.35	Relevant	0	0
2	B_cell	11.84	Significant	4.30e-29	1.32	Specific	356	694
3	thymocyte	10.27	Significant	1.74e-08	1.27	Specific	168	512
4	natural_killer_cell	6.97	Significant	2.79e-17	1.22	Specific	1,204	2,052
5	T_cell	6.81	Significant	3.30e-49	1.25	Specific	470	959
6	haematopoietic_progenitor_cell	6.66	Significant	1.00	1.02	Relevant	262	502
7	innate_lymphoid_cell_2	4.44	Nominal	1.00	0.85	Other	3	8
8	plasma_cell	3.70	Nominal	1.00	0.87	Other	17	24
9	epithelial_cell	2.35	Nonsignificant	1.00	0.82	Other	24	47
10	hepatocyte	1.90	Nonsignificant	1.00	0.79	Other	1,515	3,822
11	platelet	1.21	Nonsignificant	—	0.02	Other	85	104
12	dendritic_cell	0.92	Nonsignificant	1.00	0.72	Other	496	724
13	granulocyte	0.78	Nonsignificant	1.00	0.65	Other	5	6
14	skeletal_muscle_cell	0.50	Nonsignificant	1.00	0.79	Other	944	2,600
15	smooth_muscle_cell	0.26	Nonsignificant	1.00	0.61	Other	27	139
16	monocyte	0.25	Nonsignificant	1.00	0.60	Other	2,176	3,871
17	cardiomyocyte	0.08	Nonsignificant	1.00	0.51	Other	533	2,045
18	astrocyte	0.07	Nonsignificant	1.00	0.51	Other	256	1,203
19	muscle_stem_cell	0.04	Nonsignificant	1.00	0.44	Other	7	27
20	macrophage	0.03	Nonsignificant	1.00	0.48	Other	813	1,732
21	endothelial_cell	0.03	Nonsignificant	1.00	0.42	Other	373	974
22	granulosa_cell	0.03	Nonsignificant	1.00	0.45	Other	293	670
23	fibroblast	0.03	Nonsignificant	1.00	0.53	Other	184	826
24	neuron	0.02	Nonsignificant	1.00	0.51	Other	330	1,328
25	pericyte	0.02	Nonsignificant	1.00	0.44	Other	128	517
26	microglia	9.53e-03	Nonsignificant	1.00	0.38	Other	61	129
27	schwann_cell	6.05e-03	Nonsignificant	1.00	0.34	Other	10	57
28	oligodendrocyte_precursor_cell	6.03e-03	Nonsignificant	1.00	0.37	Other	461	1,454
29	adipose_stem_and_progenitor_cell	2.66e-03	Nonsignificant	1.00	0.31	Other	327	954
30	mesothelial_cell	2.45e-03	Nonsignificant	1.00	0.35	Other	6	36
31	melanocyte	7.66e-04	Nonsignificant	1.00	0.36	Other	97	309
32	oligodendrocyte	7.29e-04	Nonsignificant	1.00	0.46	Other	385	1,507
33	chondrocyte	5.28e-04	Nonsignificant	1.00	0.27	Other	548	1,069
34	adipocyte	6.14e-06	Nonsignificant	1.00	0.17	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_ductal_mucinous	34.42	Significant	0.01	1.53	Specific	219	430
2	T.CD4_Treg	29.00	Significant	5.78e-45	2.78	Specific	244	511
3	IPSC.induced_pluripotent_stem_cell	13.37	Significant	—	—	Relevant	0	0
4	T.CD4_Trm	12.96	Significant	3.97e-20	2.17	Specific	176	363
5	EPI.colonocyte	12.48	Significant	2.11e-16	1.63	Specific	294	815
6	B.naive	12.39	Significant	0.02	1.42	Specific	307	595
7	B.memory	11.77	Significant	1.00	0.83	Specific	442	882
8	T.CD4_Tfh	11.51	Significant	1.79e-04	1.80	—	47	45
9	THYMO.thymocyte	10.27	Significant	—	—	Specific	163	495
10	T.CD8_Trm	9.55	Significant	2.47e-06	1.68	Specific	211	346
11	T.CD8_Tcm	8.33	Significant	0.03	1.38	Specific	460	926
12	T.CD4_Tcm	7.73	Significant	2.06e-04	1.37	Specific	494	988
13	T.CD4_transitional	7.64	Significant	0.10	1.29	Relevant	48	110
14	T.CD8_Tem	7.49	Significant	5.25e-05	1.45	Specific	1,083	1,857
15	T.CD8_transitional	7.37	Significant	0.18	1.14	Specific	497	932
16	T.CD4_Tem	7.36	Significant	0.06	1.29	Relevant	365	697
17	NK.natural_killer_cell	6.97	Significant	—	—	Specific	1,204	2,045
18	B.age_associated	6.75	Significant	1.00	0.19	Relevant	207	350
19	HPC.haematopoietic_progenitor_cell	6.66	Significant	—	—	—	211	370
20	T.CD4_cytotoxic	5.50	Nominal	1.00	0.72	Other	855	1,493
21	EPI.renal_proximal_tubule	5.28	Nominal	0.04	1.43	Other	525	806
22	PC.IgG_systemic	4.94	Nominal	0.09	1.38	Other	41	60
23	T.CD4_Th17	4.87	Nominal	1.00	0.55	Other	421	794
24	ILC2.innate_lymphoid_cell_2	4.44	Nominal	—	—	Other	2	0
25	T.CD4_Th2	4.27	Nominal	—	0.00	Other	1	2
26	EPI.esophageal_suprabasal	4.20	Nominal	0.44	1.27	Other	158	404
27	T.CD4_naive	4.16	Nominal	1.00	0.18	Other	399	866
28	PC.IgA_muocsal	3.53	Nominal	0.99	0.53	Other	18	31
29	T.gamma_delta	3.48	Nominal	1.00	0.21	Other	588	1,078
30	EPI.bile_duct_cholangiocyte	3.48	Nominal	1.00	1.08	Other	37	60
31	EPI.ileal_goblet	3.40	Nominal	1.00	1.23	Other	181	432
32	EPI.pancreatic_islet	3.39	Nominal	1.00	1.10	Other	52	132
33	T.CD8_naive	3.20	Nominal	1.00	0.07	Other	317	708
34	T.MAIT	2.93	Nonsignificant	1.00	0.02	Other	469	855
35	HEP.periportal_metabolic	2.85	Nonsignificant	4.29e-13	1.68	Other	1,750	4,427
36	EPI.ileal_enterocyte_crypt	2.74	Nonsignificant	1.00	0.87	Other	67	113
37	EPI.pancreatic_ductal_bicarbonate	2.66	Nonsignificant	1.00	0.96	Other	131	548
38	EPI.ileal_enterocyte_absorptive	2.59	Nonsignificant	1.00	1.00	Other	118	338
39	EPI.colonic_enteroendocrine	2.48	Nonsignificant	—	0.52	Other	1	1
40	EPI.pancreatic_acinar	2.42	Nonsignificant	1.00	1.03	Other	429	1,475
41	EPI.salivary_serous_acinar	2.16	Nonsignificant	1.00	1.07	Other	233	531
42	EPI.colonic_tuft	2.09	Nonsignificant	—	0.57	Other	7	24
43	EPI.esophageal_basal	2.08	Nonsignificant	1.00	0.92	Other	4	10
44	EPI.intrahepatic_cholangiocyte_defense	1.95	Nonsignificant	—	0.39	Other	8	13
45	EPI.lung_multiciliated	1.89	Nonsignificant	1.00	1.02	Other	16	49
46	DC.mig	1.82	Nonsignificant	—	0.88	Other	89	156
47	HEP.acute_phase	1.80	Nonsignificant	1.00	0.93	Other	1,441	3,641
48	EPI.renal_intercalated_cell_type_B	1.71	Nonsignificant	—	0.44	Other	6	7
49	EPI.tracheal_basal	1.57	Nonsignificant	1.00	0.93	Other	398	1,120
50	EPI.intrahepatic_cholangiocyte_transport	1.53	Nonsignificant	—	0.26	Other	12	42
51	EPI.pancreatic_ductal_progenitor	1.45	Nonsignificant	1.00	0.98	Other	234	873
52	EPI.pancreatic_ductal_perivascular	1.41	Nonsignificant	1.00	0.79	Other	4	30
53	EPI.extrahepatic_cholangiocyte	1.38	Nonsignificant	—	0.17	Other	37	71
54	PLAT.platelet	1.21	Nonsignificant	—	0.00	Other	38	53
55	SKM.type_1_slow	1.17	Nonsignificant	2.53e-22	1.64	Other	923	2,478
56	GRANU.MAST	1.14	Nonsignificant	9.43e-04	1.93	Other	5	6
57	DC.cDC2	1.14	Nonsignificant	4.06e-05	1.58	Other	1,189	1,793
58	EPI.lung_club_secretory	1.09	Nonsignificant	1.00	0.60	Other	5	14
59	EPI.hepatic_ductular_cholangiocyte	1.07	Nonsignificant	1.00	0.77	Other	83	243
60	HEP.canalicular_transport	1.04	Nonsignificant	1.00	0.39	Other	1,290	3,434
61	EPI.thymic_medullary	1.03	Nonsignificant	1.00	0.70	Other	26	133
62	EPI.renal_intercalated_cell_type_A	0.94	Nonsignificant	1.00	0.71	Other	67	142
63	NEU.EXC_SYT2	0.93	Nonsignificant	—	2.27	Other	40	77
64	EPI.gastric_foveolar	0.90	Nonsignificant	—	0.04	Other	0	0
65	FIB.skin_sheath	0.82	Nonsignificant	0.03	1.22	Other	49	118
66	B.germinal_center	0.82	Nonsignificant	1.00	0.00	Other	233	655
67	EPI.ileal_bile_transport	0.80	Nonsignificant	1.00	0.65	Other	61	93
68	EPI.salivary_mucous_acinar	0.74	Nonsignificant	1.00	0.65	Other	639	1,189
69	MAC.microglia_like	0.72	Nonsignificant	0.49	1.19	Other	124	179
70	EPI.tracheal_suprabasal	0.72	Nonsignificant	1.00	0.58	Other	29	56
71	MONO.CD16	0.71	Nonsignificant	4.73e-16	1.47	Other	1,304	1,835
72	EPI.renal_principal_cell	0.62	Nonsignificant	1.00	0.49	Other	207	403
73	EPI.alveolar_type_2	0.59	Nonsignificant	1.00	0.54	Other	813	1,853
74	FIB.skin_neurosecretory	0.53	Nonsignificant	—	2.25	Other	0	0
75	EPI.cervical_suprabasal	0.52	Nonsignificant	—	0.00	Other	14	50
76	FIB.skin_papillary	0.49	Nonsignificant	—	2.12	Other	0	0
77	EPI.renal_distal_tubule	0.44	Nonsignificant	1.00	0.50	Other	133	361
78	EPI.tracheal_submucosal_gland	0.42	Nonsignificant	—	0.00	Other	0	0
79	EPI.skin_keratinocyte_basal	0.32	Nonsignificant	—	0.00	Other	13	26
80	EPI.alveolar_type_1	0.32	Nonsignificant	1.00	0.48	Other	26	101
81	SMC.smooth_muscle_cell	0.26	Nonsignificant	—	—	Other	20	101
82	FIB.skin_tenogenic	0.26	Nonsignificant	—	1.75	Other	108	227
83	FIB.suburothelial	0.24	Nonsignificant	0.37	1.09	Other	122	432
84	EPI.salivary_duct_ion_transport	0.18	Nonsignificant	1.00	0.44	Other	5	11
85	MONO.CD14	0.16	Nonsignificant	1.00	0.15	Other	2,294	4,139
86	EC.liver_sinusoidal	0.15	Nonsignificant	0.09	1.15	Other	1,083	1,925
87	GRANU.neutrophil	0.15	Nonsignificant	1.00	0.00	Other	1,235	2,649
88	EC.lymphatic	0.14	Nonsignificant	0.09	1.15	Other	630	998
89	EPI.thymic_cortical	0.12	Nonsignificant	1.00	0.42	Other	442	824
90	FIB.lung_alveolar	0.12	Nonsignificant	—	1.32	Other	6	15
91	DC.pDC	0.12	Nonsignificant	1.00	0.24	Other	496	1,028
92	EPI.salivary_myoepithelial	0.09	Nonsignificant	1.00	0.38	Other	191	714
93	FIB.hepatic_stellate_cell	0.09	Nonsignificant	—	1.30	Other	64	252
94	EPI.renal_immature_ureteric_bud	0.09	Nonsignificant	1.00	0.35	Other	217	569
95	MAC.MDM	0.09	Nonsignificant	1.00	1.04	Other	623	986
96	CM.cardiomyocyte	0.08	Nonsignificant	—	—	Other	524	2,032
97	FIB.neurolectin_mucosa	0.08	Nonsignificant	1.00	0.97	Other	133	394
98	FIB.perivascular_interface	0.08	Nonsignificant	1.00	1.02	Other	0	0
99	ASTRO.astrocyte	0.07	Nonsignificant	—	—	Other	228	1,111
100	EPI.endocervical_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
101	EPI.skin_interfollicular_spinous	0.05	Nonsignificant	1.00	0.29	Other	260	563
102	EC.capillary	0.04	Nonsignificant	0.77	1.01	Other	514	1,635
103	EPI.ectocervical_granular	0.04	Nonsignificant	—	0.00	Other	11	23
104	MUSC.muscle_stem_cell	0.04	Nonsignificant	—	—	Other	4	18
105	FIB.barrier_purinergic	0.04	Nonsignificant	—	1.07	Other	1	3
106	MAC.resident_iron	0.03	Nonsignificant	1.00	0.99	Other	16	21
107	EPI.skin_follicular_keratinizing	0.03	Nonsignificant	1.00	0.29	Other	30	81
108	GRNLSA.granulosa_cell	0.03	Nonsignificant	—	—	Other	257	0
109	EPI.salivary_intercalated_defense	0.03	Nonsignificant	1.00	0.30	Other	81	161
110	DC.cDC1	0.03	Nonsignificant	1.00	0.08	Other	55	112
111	NEU.EXC_CT	0.02	Nonsignificant	1.00	1.07	Other	362	384
112	EPI.skin_keratinocyte_proliferating	0.02	Nonsignificant	1.00	0.28	Other	47	76
113	EPI.skin_appendage_keratinocyte	0.02	Nonsignificant	1.00	0.23	Other	87	222
114	PERI.pericyte	0.02	Nonsignificant	—	—	Other	117	0
115	MAC.resident_repair	0.01	Nonsignificant	1.00	0.96	Other	796	1,426
116	EC.arterial	0.01	Nonsignificant	1.00	0.92	Other	356	885
117	EPI.skin_hair_follicle_bulge	0.01	Nonsignificant	1.00	0.21	Other	51	178
118	SKM.type_2_fast	0.01	Nonsignificant	1.00	0.00	Other	972	2,639
119	MG.microglia	9.53e-03	Nonsignificant	—	—	Other	49	0
120	EC.venous	8.40e-03	Nonsignificant	1.00	0.85	Other	516	1,387
121	FIB.reticular	7.13e-03	Nonsignificant	1.00	0.87	Other	19	87
122	FIB.tracheal_subepithelial	7.07e-03	Nonsignificant	—	0.90	Other	0	0
123	MAC.LAM	6.64e-03	Nonsignificant	1.00	0.87	Other	914	2,064
124	EPI.skin_keratinocyte_progenitor	6.30e-03	Nonsignificant	—	0.00	Other	0	3
125	SCHWN.schwann_cell	6.05e-03	Nonsignificant	—	—	Other	7	33
126	OPC.oligodendrocyte_precursor_cell	6.03e-03	Nonsignificant	—	—	Other	413	1,269
127	NEU.EXC_IT	5.47e-03	Nonsignificant	1.00	0.90	Other	411	192
128	NEU.INH_VIP	4.54e-03	Nonsignificant	1.00	1.00	Other	241	366
129	FIB.interstitial	3.41e-03	Nonsignificant	1.00	0.86	Other	288	940
130	ASPC.adipose_stem_and_progenitor_cell	2.66e-03	Nonsignificant	—	—	Other	324	930
131	MESO.mesothelial_cell	2.45e-03	Nonsignificant	—	—	Other	2	18
132	FIB.transitioning	2.02e-03	Nonsignificant	1.00	0.96	Other	172	497
133	MAC.kupffer	1.80e-03	Nonsignificant	1.00	0.82	Other	189	530
134	EC.heart_remodeling	1.73e-03	Nonsignificant	1.00	0.78	Other	569	1,594
135	EPI.renal_thick_ascending_limb	1.04e-03	Nonsignificant	1.00	0.12	Other	453	1,153
136	EPI.skin_hair_follicle_companion	7.93e-04	Nonsignificant	—	0.00	Other	8	12
137	MEL.melanocyte	7.66e-04	Nonsignificant	—	—	Other	79	242
138	OLG.oligodendrocyte	7.29e-04	Nonsignificant	—	—	Other	384	1,397
139	CHOND.chondrocyte	5.28e-04	Nonsignificant	—	—	Other	519	730
140	FIB.adventitial	1.85e-04	Nonsignificant	1.00	0.61	Other	268	1,447
141	MAC.resident_cardiac	1.12e-04	Nonsignificant	1.00	0.57	Other	485	1,074
142	MAC.proliferating	1.08e-04	Nonsignificant	1.00	0.70	Other	87	253
143	NEU.INH_PVALB	1.07e-04	Nonsignificant	1.00	0.60	Other	193	183
144	HEP.pericentral_lipoprotein	8.35e-05	Nonsignificant	—	0.00	Other	0	0
145	NEU.EXC_NTNG1	6.04e-05	Nonsignificant	—	0.00	Other	0	0
146	NEU.INH_LAMP5	5.48e-05	Nonsignificant	1.00	0.69	Other	263	532
147	EPI.skin_sebaceous_duct_luminal	2.16e-05	Nonsignificant	1.00	0.13	Other	100	249
148	MAC.alveolar	2.04e-05	Nonsignificant	1.00	0.69	Other	1,432	3,122
149	EPI.skin_sweat_duct_keratinocyte	1.53e-05	Nonsignificant	1.00	0.17	Other	146	301
150	FIB.barrier_secretory	1.47e-05	Nonsignificant	1.00	0.63	Other	81	228
151	ADIPO.adipocyte	6.14e-06	Nonsignificant	—	—	Other	20	62
152	EPI.salivary_duct_excretory	3.79e-06	Nonsignificant	1.00	0.08	Other	85	180

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	45.18	Significant	0.04	1.78	Specific	449	1,034
2	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	44.90	Significant	—	0.10	Relevant	0	0
3	T.CD4_Treg.Tr1_like	36.35	Significant	—	0.47	—	8	8
4	T.CD4_Treg.APC_interactive	31.32	Significant	0.33	1.39	—	118	28
5	T.CD4_Treg.central_naive_like	31.15	Significant	0.67	0.98	—	333	45
6	IPSC.stress	28.12	Significant	2.50e-09	2.48	Relevant	0	0
7	B.memory.preactivated	19.98	Significant	5.73e-05	2.21	—	173	174
8	IPSC.mesenchymal_primed	19.12	Significant	2.50e-09	1.98	—	0	0
9	EPI.colonocyte.secretory_boost	18.20	Significant	0.11	1.72	—	98	91
10	HPC.MPP_activated	17.59	Significant	—	1.76	—	0	0
11	IPSC.mesendo_primed	16.95	Significant	1.20e-07	1.86	—	0	0
12	IPSC.midbrain_primed	16.94	Significant	0.74	1.13	Relevant	0	0
13	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	16.83	Significant	—	0.00	—	0	0
14	IPSC.stromal_primed	16.24	Significant	0.57	1.15	—	0	0
15	T.CD4_Trm.stress_adaptive	15.90	Significant	0.55	1.40	—	8	22
16	B.naive.restrained	15.69	Significant	5.81e-03	1.70	Specific	183	353
17	EPI.colonocyte.ionocyte_BEST4	15.49	Significant	0.11	1.77	—	103	188
18	T.CD4_Tfh.precursor_migratory	15.22	Significant	0.08	1.59	—	72	27
19	EPI.colonocyte.goblet_interface	14.53	Significant	—	0.36	Relevant	11	21
20	B.naive.activated	14.30	Significant	0.53	1.31	Specific	77	127
21	B.memory.activated	14.25	Significant	9.39e-03	1.77	—	105	29
22	T.CD4_Trm.central_like	14.00	Significant	0.55	1.32	—	38	31
23	THYMO.SP_CD8_naive	13.80	Significant	1.01e-04	1.94	—	297	177
24	B.naive.proteostasis	13.73	Significant	0.75	1.13	Relevant	49	69
25	T.CD4_Trm.activated	13.47	Significant	0.74	0.98	—	32	26
26	T.CD4_Trm.cytotoxic_effector	13.46	Significant	0.61	1.20	—	118	77
27	EPI.colonocyte.junction_remodeling	13.38	Significant	0.34	1.34	—	218	305
28	T.CD4_Tcm.APC_mimicry	13.32	Significant	9.60e-03	2.00	—	54	43
29	IPSC.neural_primed	13.27	Significant	1.00	0.81	—	0	0
30	IPSC.canonical_pluripotent	13.22	Significant	1.00	0.90	—	0	0
31	B.naive.purinergic	13.09	Significant	0.53	1.20	Specific	384	820
32	T.CD4_Tfh.effector_migratory	12.36	Significant	0.41	1.27	—	122	57
33	T.CD4_Treg.tissue_effector	12.35	Significant	0.67	0.85	—	16	13
34	T.CD4_naive.activated_stress	12.30	Significant	7.84e-11	2.82	—	339	429
35	THYMO.DP_early	12.24	Significant	0.73	1.18	—	326	313
36	T.CD4_Trm.metal_stress	12.06	Significant	0.77	0.83	Relevant	34	58
37	T.CD4_Trm.baseline	12.05	Significant	0.74	0.98	—	31	21
38	T.CD4_naive.Treg_like	11.84	Significant	2.88e-05	2.50	—	121	72
39	EPI.colonocyte.crypt_progenitor	11.79	Significant	0.91	0.76	Relevant	115	265
40	B.naive.antigen_presenting_ready	11.36	Significant	0.86	1.01	Relevant	48	73
41	B.naive.remodeling	11.36	Significant	1.00	0.58	Relevant	135	230
42	T.CD4_transitional.APC_interacting	11.14	Significant	0.02	2.04	—	10	14
43	B.memory.baseline	11.02	Significant	1.00	0.78	—	472	99
44	THYMO.proliferative_G2M	10.86	Significant	—	0.02	—	164	413
45	T.CD4_Trm.helper_like	10.75	Significant	0.85	0.66	Relevant	84	147
46	T.CD4_Tcm.Tfh_like	10.52	Significant	0.01	1.81	Specific	102	214
47	THYMO.SP_CD4_naive	10.44	Significant	1.00	0.77	—	65	75
48	T.CD4_Tcm.baseline	10.43	Significant	0.27	1.49	—	61	31
49	T.CD8_Trm.cytotoxic	10.36	Significant	0.77	1.17	—	165	85
50	T.CD8_Trm.muscosal_Tc17	10.24	Significant	0.77	0.99	Relevant	19	38
51	IPSC.axial_identity_primed	10.22	Significant	1.00	0.51	—	0	0
52	THYMO.DP_early_stress	10.17	Significant	—	0.00	—	0	0
53	THYMO.SP_CD8_naive_stress	10.09	Significant	1.00	0.91	—	1	1
54	HPC.MPP_IEG	10.08	Significant	0.19	1.56	—	45	46
55	T.CD4_Tem.transitional_CM	9.90	Significant	9.55e-05	2.33	—	31	20
56	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	9.64	Significant	—	0.00	—	0	0
57	T.CD8_Trm.homeostatic	9.52	Significant	0.77	1.06	—	42	5
58	NK.adaptive_immature_precursor	9.46	Significant	7.14e-07	2.98	—	358	111
59	T.CD8_Trm.inflammatory	9.40	Significant	0.77	0.91	Relevant	124	176
60	T.CD4_Tfh.suppression_exhaustion	9.35	Significant	1.00	0.57	—	0	2
61	T.CD8_Tcm.helper_like	9.33	Significant	0.10	1.78	Relevant	81	159
62	NK.adaptive_biosynthetic_primed	9.17	Significant	0.09	1.75	Relevant	244	405
63	T.CD4_transitional.primed_helper_effector	9.00	Significant	0.12	1.59	Relevant	19	43
64	B.memory.pDC_imprint	8.86	Significant	1.00	0.47	—	157	103
65	T.CD8_transitional.early	8.83	Significant	5.49e-03	1.72	—	327	55
66	T.CD8_Tcm.baseline	8.71	Significant	0.96	1.01	—	90	89
67	EPI.colonocyte.proximal_transport	8.61	Significant	0.98	0.27	—	24	12
68	T.CD8_Tcm.NK_like	8.60	Significant	0.96	0.77	Relevant	334	581
69	B.naive.metabolic	8.43	Significant	1.00	0.15	Relevant	50	79
70	T.CD8_Tem.early_helper_like	8.41	Significant	0.42	1.47	Relevant	445	755
71	NK.adaptive_axis_baseline	8.28	Significant	2.77e-03	2.06	—	1,008	153
72	NK.adaptive_adipose_stress	8.21	Significant	0.01	2.01	—	374	39
73	THYMO.CD8aa_IELp	8.12	Significant	—	0.00	—	1	7
74	HPC.LMPP	7.99	Significant	0.54	1.18	—	65	31
75	NK.adaptive_HLAE_tuned	7.96	Significant	1.17e-04	2.36	—	1,124	189
76	NK.adaptive_classII_inhibitory	7.92	Significant	8.16e-04	2.32	—	880	154
77	T.CD8_Tem.motility_primed	7.91	Significant	0.47	1.13	—	269	4
78	T.CD8_Tcm.gut_homing	7.83	Significant	0.96	0.64	—	380	112
79	T.CD4_Tem.inflammatory	7.82	Significant	0.68	1.00	—	28	6
80	ILC2.quiescent	7.72	Significant	—	1.03	Relevant	0	0
81	T.CD8_Tem.stress_adapted	7.71	Significant	0.47	1.08	—	607	520
82	T.CD8_transitional.effector_primed	7.71	Significant	0.07	1.49	—	435	151
83	B.age_associated.naive_transitional	7.62	Significant	—	0.59	—	0	0
84	T.CD8_Tem.TEMRA	7.60	Significant	0.47	1.14	—	920	1,088
85	B.memory.migratory	7.59	Significant	1.00	0.06	Relevant	123	208
86	T.CD8_Tem.signaling_turnover	7.52	Significant	0.47	1.34	Relevant	425	683
87	NK.cytokine_tissue_activation	7.46	Significant	0.52	1.31	Relevant	267	450
88	T.CD4_Tcm.migratory_cilium	7.39	Significant	1.00	1.00	—	5	10
89	T.CD4_Tem.cytotoxic_effector	7.36	Significant	0.68	1.05	Relevant	225	398
90	B.naive.receptor_recycle	7.34	Significant	1.00	0.10	—	51	0
91	T.CD4_Tcm.RNA_control	7.30	Significant	1.00	0.94	—	96	4
92	T.MAIT.stress	7.28	Significant	—	1.61	—	0	0
93	T.CD4_Tcm.crosstalk_myeloid	7.23	Significant	1.00	0.82	—	5	4
94	T.CD4_Tcm.secretory	7.21	Significant	1.00	0.52	—	20	11
95	PC.IgG_systemic.interacting	7.14	Significant	0.29	1.34	Relevant	0	0
96	T.CD4_transitional.baseline	7.11	Significant	0.71	0.93	Relevant	59	97
97	EPI.pancreatic_islet.delta	7.10	Significant	—	1.64	Relevant	0	0
98	B.age_associated.activated	7.01	Significant	—	0.28	Relevant	18	22
99	T.CD4_Tcm.synapse_dynamics	6.95	Significant	1.00	0.68	—	15	10
100	T.CD4_Tcm.effector_like	6.95	Significant	1.00	1.01	Relevant	293	533
101	T.CD4_transitional.primed_cytotoxic	6.94	Significant	0.71	0.86	—	28	30
102	T.CD4_Tcm.DC_interact	6.93	Significant	1.00	0.71	—	72	32
103	B.naive.baseline	6.86	Significant	1.00	0.23	Relevant	10	13
104	T.CD4_Tcm.retro_ZNF117	6.80	Significant	1.00	0.70	Relevant	5	9
105	NK.cytokine_lung_immediate_early	6.80	Significant	0.82	1.08	—	424	274
106	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	6.75	Significant	—	1.37	Relevant	0	0
107	T.CD4_cytotoxic.NK_adapted	6.75	Significant	0.14	1.80	Relevant	82	33
108	T.CD8_Tcm.effector_bias	6.69	Significant	0.96	0.37	Relevant	199	329
109	T.CD4_Tcm.regulatory_poised	6.67	Significant	1.00	0.91	—	2	3
110	NK.cytokine_tissue_resident	6.63	Significant	0.87	0.98	—	74	82
111	PC.IgA_muocsal.plasmablast	6.60	Significant	6.74e-03	1.78	Other	5	4
112	NK.cytokine_axis_baseline	6.57	Significant	1.00	0.88	—	1,172	116
113	NK.cytokine_quiescent	6.56	Significant	1.00	0.55	Relevant	623	1,062
114	NK.cytokine_vascular_patrolling	6.52	Significant	1.00	0.53	—	863	94
115	T.CD8_Tem.baseline	6.47	Significant	1.00	0.20	—	458	356
116	PC.IgG_systemic.metabolic	6.46	Significant	0.29	1.37	Relevant	46	63
117	T.CD8_Trm.dendritic_recruiter	6.34	Significant	1.00	0.05	Relevant	47	85
118	T.CD8_transitional.Trm_primed	6.33	Significant	1.00	0.54	—	108	15
119	EPI.colonocyte.distal_absorptive	6.28	Significant	—	0.00	—	0	0
120	T.CD4_Tcm.tissue_homing	6.21	Significant	1.00	0.42	—	78	46
121	B.age_associated.migratory	6.16	Significant	0.87	0.38	Relevant	2	2
122	IPSC.proliferative	6.06	Significant	1.00	0.05	—	0	0
123	NK.cytokine_repair_primed	5.96	Significant	1.00	0.26	—	266	11
124	NK.cytokine_biosynthetic_primed	5.94	Significant	1.00	0.24	—	360	21
125	T.CD4_cytotoxic.activated	5.81	Significant	0.99	0.86	Relevant	3	1
126	T.CD4_cytotoxic.terminal_effector	5.60	Significant	0.68	1.22	—	286	21
127	T.CD4_Tcm.Th2_like	5.58	Significant	1.00	0.49	Other	23	55
128	T.CD8_transitional.APC_like	5.57	Significant	1.00	0.21	Other	205	62
129	EPI.colonic_enteroendocrine.progenitor	5.47	Nominal	—	0.97	Relevant	0	0
130	EPI.renal_proximal_tubule.detox_antioxidant	5.46	Nominal	0.14	1.94	Relevant	394	77
131	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	5.43	Nominal	0.15	1.70	Other	219	533
132	T.CD4_naive.gut_prone	5.42	Nominal	0.39	1.54	Other	35	70
133	T.CD8_transitional.stress	5.39	Nominal	—	0.00	Other	24	34
134	T.CD4_transitional.tissue_enagement	5.28	Nominal	0.71	0.79	Other	5	11
135	T.CD4_Tem.long_term_memory	5.24	Nominal	1.00	0.18	Other	314	587
136	T.CD4_Tcm.imprinted_splicing	5.22	Nominal	1.00	0.17	Other	6	17
137	HPC.MEP	5.17	Nominal	0.74	0.81	Other	599	1,195
138	NK.immature_bridge	5.15	Nominal	1.00	0.11	Other	117	122
139	T.CD8_naive.mito_proteostasis	5.13	Nominal	6.94e-05	2.52	Other	428	100
140	NK.adaptive_terminal_cytotoxic	5.13	Nominal	1.00	0.12	Other	485	802
141	T.CD4_Th2.tissue_adapted	5.11	Nominal	—	0.00	Other	0	0
142	EPI.bile_duct_cholangiocyte.inflammatory_APC	5.09	Nominal	—	0.76	Other	2	0
143	EPI.esophageal_suprabasal.proliferative_G2M	5.07	Nominal	—	0.62	Other	0	0
144	EPI.renal_proximal_tubule.onecarbon_peroxisome	5.02	Nominal	0.92	0.28	Other	58	89
145	T.CD4_Th17.cytotoxic	4.99	Nominal	0.38	1.37	Other	332	123
146	EPI.pancreatic_acinar.quiet_dedifferentiation	4.92	Nominal	0.04	1.51	Other	142	171
147	T.CD4_Tcm.stress	4.91	Nominal	1.00	0.45	Other	5	11
148	T.CD4_Tfh.canonical_GC_helper	4.86	Nominal	1.00	0.06	Other	1	2
149	T.CD4_Th17.migratory	4.85	Nominal	0.43	1.20	Other	13	23
150	T.CD4_Th17.baseline	4.82	Nominal	0.56	0.95	Other	51	5
151	T.CD4_naive.purinergic	4.54	Nominal	0.86	1.13	Other	49	1
152	PC.IgG_systemic.stress	4.48	Nominal	—	0.00	Other	1	5
153	EPI.esophageal_suprabasal.basal_transitional	4.45	Nominal	0.26	1.35	Other	44	67
154	EPI.ileal_enterocyte_absorptive.brush_border	4.45	Nominal	5.48e-08	2.01	Other	580	1,717
155	EPI.ileal_enterocyte_crypt.secretory_precursor	4.35	Nominal	—	0.99	Other	0	0
156	T.CD4_cytotoxic.precursor	4.34	Nominal	0.99	0.33	Other	156	67
157	EPI.esophageal_suprabasal.differentiating_keratin	4.32	Nominal	0.26	1.37	Other	131	61
158	HPC.GMP_inflammatory	4.31	Nominal	0.54	1.09	Other	20	10
159	T.CD4_naive.proteostasis_mitoprot	4.30	Nominal	0.86	1.16	Other	15	37
160	T.CD4_naive.survival_neddylation	4.30	Nominal	0.87	0.96	Other	26	38
161	T.MAIT.migratory	4.28	Nominal	0.41	1.46	Other	10	1
162	T.CD4_naive.neddylation	4.25	Nominal	0.87	1.06	Other	104	222
163	T.CD4_naive.proteostasis	4.21	Nominal	0.87	1.03	Other	14	9
164	T.CD4_naive.neddylation_mitoprot	4.19	Nominal	0.56	1.28	Other	93	56
165	HEP.periportal_metabolic.xenobiotic_detox	4.15	Nominal	9.43e-05	1.95	Other	1,440	139
166	EPI.ileal_enterocyte_crypt.baseline	4.13	Nominal	0.50	1.35	Other	11	6
167	T.CD4_naive.mature_mitoprot	4.10	Nominal	0.87	0.96	Other	212	476
168	T.CD4_naive.resist_bystander	3.89	Nominal	1.00	0.60	Other	40	25
169	EPI.ileal_goblet.stress_metallothionein	3.88	Nominal	—	0.89	Other	4	11
170	HEP.periportal_metabolic.canonical_urea_cycle	3.84	Nominal	9.43e-05	1.97	Other	1,464	269
171	PC.IgA_muocsal.migratory	3.84	Nominal	0.25	1.17	Other	4	1
172	T.CD4_naive.homeostatic	3.81	Nominal	1.00	0.70	Other	215	108
173	T.CD4_naive.mature	3.81	Nominal	1.00	0.53	Other	211	100
174	EPI.pancreatic_islet.beta	3.74	Nominal	0.40	1.17	Other	42	57
175	PC.IgA_muocsal.activated	3.74	Nominal	0.25	1.23	Other	17	8
176	EPI.ileal_goblet.inflammatory_mucin	3.74	Nominal	0.73	1.13	Other	6	9
177	T.CD4_Th2.precursor	3.70	Nominal	—	0.00	Other	0	0
178	EPI.esophageal_basal.junctional_barrier	3.65	Nominal	—	1.21	Other	0	0
179	T.gamma_delta.central_memory	3.61	Nominal	0.73	0.90	Other	460	919
180	T.gamma_delta.cytotoxic_effector	3.59	Nominal	0.46	1.35	Other	349	109
181	EPI.pancreatic_acinar.baseline	3.59	Nominal	0.05	1.36	Other	274	163
182	T.CD4_naive.survival	3.47	Nominal	1.00	0.36	Other	12	17
183	T.CD8_naive.vesicle_secretory	3.43	Nominal	0.75	1.34	Other	42	0
184	T.CD4_naive.survival_mitoprot	3.42	Nominal	1.00	0.44	Other	13	7
185	T.CD8_naive.lipid_synthesis	3.37	Nominal	0.92	1.14	Other	6	4
186	EPI.ileal_goblet.baseline	3.26	Nominal	0.83	0.51	Other	16	2
187	T.gamma_delta.early_effector	3.24	Nominal	0.73	0.79	Other	89	0
188	T.CD4_cytotoxic.baseline	3.23	Nominal	0.99	0.06	Other	0	0
189	T.CD8_naive.innate_like	3.22	Nominal	0.92	0.97	Other	10	1
190	HEP.periportal_metabolic.inflammatory_activated	3.22	Nominal	1.00	0.94	Other	712	1,610
191	T.CD8_naive.splicing_enriched	3.15	Nominal	0.92	0.88	Other	120	16
192	THYMO.SP_CD8_transitional	3.15	Nominal	1.00	0.32	Other	32	75
193	T.CD8_naive.cytokine_dampened	3.12	Nominal	0.92	0.65	Other	71	4
194	T.MAIT.cytotoxic	3.11	Nominal	0.92	1.04	Other	52	15
195	HEP.acute_phase.complement_metabolic	3.09	Nominal	9.67e-09	2.18	Other	1,423	3,464
196	EPI.salivary_serous_acinar.seromucous_like	3.09	Nominal	—	0.89	Other	0	0
197	T.CD8_naive.effector_transition	3.02	Nominal	0.92	1.04	Other	35	62
198	EPI.pancreatic_ductal_bicarbonate.stress	3.00	Nonsignificant	—	0.39	Other	12	33
199	ILC2.activated	2.98	Nonsignificant	—	0.00	Other	0	0
200	T.CD8_naive.baseline	2.97	Nonsignificant	0.92	0.70	Other	142	2
201	EPI.esophageal_suprabasal.proliferative_S	2.97	Nonsignificant	—	0.00	Other	26	41
202	THYMO.proliferative_S	2.92	Nonsignificant	1.00	0.00	Other	163	418
203	EPI.pancreatic_acinar.stress	2.90	Nonsignificant	0.47	1.11	Other	28	28
204	EPI.esophageal_suprabasal.proliferative_exit	2.89	Nonsignificant	—	0.00	Other	0	0
205	EPI.pancreatic_ductal_bicarbonate.inflammatory	2.86	Nonsignificant	0.39	1.52	Other	14	32
206	HEP.periportal_metabolic.stress_chaperone	2.81	Nonsignificant	—	0.08	Other	66	128
207	EPI.ileal_enterocyte_crypt.proliferative_S	2.77	Nonsignificant	0.50	1.26	Other	4	2
208	IPSC.neuroendocrine_primed	2.70	Nonsignificant	—	0.00	Other	0	0
209	T.CD8_naive.nfkb_related	2.68	Nonsignificant	0.92	0.44	Other	1	0
210	T.MAIT.quiescent	2.67	Nonsignificant	0.92	1.01	Other	100	5
211	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.60	Nonsignificant	—	1.15	Other	0	0
212	T.MAIT.early_activation	2.59	Nonsignificant	0.92	0.69	Other	57	4
213	PC.IgG_systemic.secretory	2.55	Nonsignificant	1.00	0.15	Other	0	0
214	IPSC.mesodermal_primed	2.54	Nonsignificant	1.00	4.64e-03	Other	0	0
215	EPI.pancreatic_acinar.inflammatory_regenerative	2.53	Nonsignificant	0.41	1.21	Other	25	113
216	EPI.colonic_tuft.homeostatic	2.47	Nonsignificant	—	0.42	Other	0	0
217	T.MAIT.MAPK_brake	2.46	Nonsignificant	0.92	0.56	Other	44	66
218	EPI.lung_multiciliated.stress	2.46	Nonsignificant	—	0.61	Other	67	165
219	EPI.lung_club_secretory.ciliogenesis_axoneme	2.45	Nonsignificant	—	0.00	Other	0	0
220	IPSC.endoderm_primed	2.30	Nonsignificant	1.00	0.01	Other	0	0
221	EPI.salivary_serous_acinar.secretory_active	2.28	Nonsignificant	3.96e-03	2.05	Other	242	69
222	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	2.27	Nonsignificant	—	0.42	Other	0	0
223	EPI.ileal_enterocyte_crypt.proliferative_G2M	2.26	Nonsignificant	—	0.16	Other	19	54
224	HPC.GMP_granulocytic	2.26	Nonsignificant	—	0.00	Other	3	3
225	DC.cDC2.adhesion_signaling	2.26	Nonsignificant	0.08	1.44	Other	35	9
226	HEP.periportal_metabolic.urea_onecarbon_secretory	2.23	Nonsignificant	1.00	0.55	Other	1,332	3,053
227	ILC2.migratory	2.20	Nonsignificant	—	0.00	Other	0	0
228	PC.IgA_muocsal.baseline	2.17	Nonsignificant	1.00	0.40	Other	3	5
229	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.10	Nonsignificant	—	1.55	Other	0	0
230	EPI.pancreatic_islet.alpha	2.07	Nonsignificant	—	0.00	Other	152	330
231	DC.cDC2.antiviral	2.06	Nonsignificant	0.08	1.45	Other	100	37
232	THYMO.DN_preTCR	2.02	Nonsignificant	1.00	0.08	Other	41	71
233	T.MAIT.vesicle	1.98	Nonsignificant	0.92	0.53	Other	37	65
234	EPI.ileal_goblet.immature	1.97	Nonsignificant	—	0.00	Other	0	0
235	PLAT.adhesion	1.85	Nonsignificant	—	0.48	Other	0	0
236	DC.mig.baseline	1.82	Nonsignificant	—	0.00	Other	1	0
237	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.79	Nonsignificant	—	0.00	Other	0	0
238	EPI.bile_duct_cholangiocyte.secretory_mucin	1.78	Nonsignificant	—	0.00	Other	7	12
239	EPI.hepatic_ductular_cholangiocyte.secretory_transport	1.75	Nonsignificant	—	0.70	Other	0	0
240	EPI.colonic_tuft.activated	1.72	Nonsignificant	—	0.00	Other	0	0
241	EPI.renal_intercalated_cell_type_B.baseline	1.71	Nonsignificant	—	0.00	Other	3	1
242	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.68	Nonsignificant	—	0.00	Other	49	237
243	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.68	Nonsignificant	—	0.73	Other	0	0
244	EPI.pancreatic_ductal_perivascular.baseline	1.66	Nonsignificant	0.33	1.26	Other	1	5
245	HPC.CLP_B_primed	1.65	Nonsignificant	—	0.00	Other	0	0
246	EPI.lung_multiciliated.baseline	1.65	Nonsignificant	—	0.00	Other	0	7
247	HEP.canalicular_transport.sterol_lipid_biosynthesis	1.64	Nonsignificant	—	0.77	Other	10	20
248	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.61	Nonsignificant	1.00	0.71	Other	40	191
249	HEP.canalicular_transport.inflammatory	1.59	Nonsignificant	3.05e-03	1.37	Other	1,335	194
250	EPI.tracheal_basal.homeostatic_progenitor	1.59	Nonsignificant	0.38	1.42	Other	285	74
251	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.58	Nonsignificant	—	0.00	Other	0	0
252	EPI.esophageal_basal.activated_progenitor	1.56	Nonsignificant	1.00	0.00	Other	1	0
253	GRANU.MAST.activated_acute	1.56	Nonsignificant	—	0.66	Other	0	0
254	HEP.periportal_metabolic.acute_phase_barrier	1.55	Nonsignificant	1.00	0.37	Other	533	138
255	EPI.pancreatic_ductal_bicarbonate.activated	1.55	Nonsignificant	1.00	0.25	Other	10	7
256	EPI.tracheal_basal.activated_stress	1.54	Nonsignificant	0.38	1.12	Other	32	0
257	HEP.acute_phase.baseline	1.52	Nonsignificant	1.00	0.72	Other	946	19
258	B.germinal_center.DZ_M_phase	1.49	Nonsignificant	—	1.47	Other	0	0
259	NEU.EXC_SYT2.synaptic	1.47	Nonsignificant	—	0.48	Other	0	0
260	EPI.extrahepatic_cholangiocyte.mucin_secretory	1.42	Nonsignificant	—	0.00	Other	0	0
261	EPI.pancreatic_ductal_progenitor.baseline	1.41	Nonsignificant	0.52	0.94	Other	179	702
262	EPI.pancreatic_ductal_progenitor.ADM_like	1.39	Nonsignificant	—	0.00	Other	0	0
263	EPI.extrahepatic_cholangiocyte.barrier_interface	1.35	Nonsignificant	—	0.00	Other	0	0
264	EPI.ileal_enterocyte_crypt.bile_transport	1.32	Nonsignificant	0.83	0.60	Other	2	0
265	SKM.type_1_slow.oxidative	1.31	Nonsignificant	0.37	1.47	Other	802	251
266	EPI.pancreatic_ductal_bicarbonate.baseline	1.27	Nonsignificant	1.00	0.12	Other	11	42
267	SKM.type_1_slow.contractile	1.23	Nonsignificant	0.51	1.15	Other	596	8
268	EPI.pancreatic_ductal_progenitor.ciliated_transport	1.23	Nonsignificant	—	0.00	Other	105	368
269	MONO.CD16.inflammatory	1.21	Nonsignificant	1.25e-08	1.97	Other	1,640	168
270	HEP.periportal_metabolic.apolipoprotein_secretory	1.17	Nonsignificant	1.00	0.30	Other	43	110
271	GRANU.MAST.activated_repair	1.15	Nonsignificant	—	0.00	Other	0	1
272	EPI.renal_intercalated_cell_type_A.acid_secretion	1.14	Nonsignificant	3.71e-04	2.07	Other	12	6
273	EPI.colonic_enteroendocrine.Lcell_peptide	1.14	Nonsignificant	—	0.00	Other	0	0
274	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.14	Nonsignificant	—	0.78	Other	0	0
275	EPI.thymic_medullary.canonical_alarmin	1.12	Nonsignificant	0.50	1.36	Other	8	17
276	EPI.ileal_enterocyte_crypt.villus_transition	1.10	Nonsignificant	—	0.00	Other	7	10
277	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.07	Nonsignificant	—	0.09	Other	6	9
278	HEP.acute_phase.complement_antiviral	1.04	Nonsignificant	1.00	0.44	Other	377	751
279	EPI.pancreatic_ductal_perivascular.protective_antioxidant	1.02	Nonsignificant	—	0.00	Other	11	69
280	HEP.acute_phase.proliferative	1.01	Nonsignificant	—	0.00	Other	4	6
281	EPI.hepatic_ductular_cholangiocyte.polarity	1.00	Nonsignificant	—	0.08	Other	0	0
282	MAC.microglia_like.phagocytic_redox	1.00	Nonsignificant	—	0.20	Other	0	0
283	EPI.thymic_medullary.hormone_xeno_barrier	0.99	Nonsignificant	—	0.00	Other	0	8
284	EPI.renal_principal_cell.activated_acute	0.99	Nonsignificant	0.69	1.23	Other	29	59
285	EPI.thymic_medullary.proliferative_APC	0.99	Nonsignificant	—	0.00	Other	0	0
286	EPI.thymic_medullary.stress_APC	0.96	Nonsignificant	0.86	0.46	Other	2	4
287	HEP.canalicular_transport.injury_stress	0.96	Nonsignificant	0.71	1.13	Other	289	24
288	EPI.hepatic_ductular_cholangiocyte.stress	0.94	Nonsignificant	—	0.00	Other	0	0
289	FIB.skin_sheath.stress_chaperone	0.94	Nonsignificant	—	0.00	Other	0	0
290	CM.contractile_oxphos	0.93	Nonsignificant	6.68e-06	1.75	Other	6	19
291	HEP.periportal_metabolic.stress_checkpoint	0.93	Nonsignificant	1.00	0.05	Other	234	786
292	MAC.microglia_like.inflammatory_chemokine	0.90	Nonsignificant	—	0.51	Other	20	32
293	EPI.renal_distal_tubule.immune_modulatory	0.90	Nonsignificant	—	0.86	Other	0	0
294	EPI.gastric_foveolar.baseline	0.90	Nonsignificant	—	0.00	Other	0	0
295	DC.cDC2.tolerogenic_regulatory	0.89	Nonsignificant	0.93	0.84	Other	44	4
296	EPI.lung_club_secretory.ciliogenesis_primed	0.89	Nonsignificant	—	0.79	Other	0	0
297	GRANU.MAST.resting_granule	0.89	Nonsignificant	—	0.00	Other	0	0
298	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.87	Nonsignificant	—	0.00	Other	5	3
299	EPI.renal_principal_cell.inflammatory	0.87	Nonsignificant	0.24	1.54	Other	74	157
300	SKM.type_1_slow.glycolytic	0.85	Nonsignificant	0.92	0.44	Other	362	647
301	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.84	Nonsignificant	—	0.00	Other	0	0
302	EPI.tracheal_suprabasal.secretory_immune	0.84	Nonsignificant	—	0.38	Other	0	0
303	HEP.acute_phase.hypoxia_lipid	0.83	Nonsignificant	—	0.00	Other	0	0
304	EPI.ileal_bile_transport.absorptive_xenobiotic	0.83	Nonsignificant	0.13	1.64	Other	11	12
305	EPI.lung_club_secretory.inflammatory	0.83	Nonsignificant	—	0.37	Other	0	0
306	B.germinal_center.LZ_selection	0.83	Nonsignificant	—	0.00	Other	0	0
307	EPI.cervical_suprabasal.inflammatory_repair	0.81	Nonsignificant	—	0.73	Other	0	0
308	MONO.CD16.baseline	0.79	Nonsignificant	0.68	0.96	Other	50	1
309	FIB.skin_sheath.neuro_vascular_interface	0.78	Nonsignificant	—	0.00	Other	0	0
310	B.germinal_center.LZ_survival	0.77	Nonsignificant	—	0.00	Other	0	0
311	EPI.alveolar_type_2.baseline_surfactant	0.76	Nonsignificant	0.11	1.55	Other	64	9
312	HEP.acute_phase.inflammatory	0.75	Nonsignificant	1.00	0.02	Other	382	649
313	FIB.skin_sheath.ECM_immune	0.75	Nonsignificant	—	6.94e-17	Other	0	0
314	EPI.salivary_mucous_acinar.baseline	0.74	Nonsignificant	—	—	Other	394	683
315	MONO.CD16.platelet_bound	0.73	Nonsignificant	0.68	1.01	Other	372	508
316	EPI.alveolar_type_2.stress_response	0.72	Nonsignificant	0.01	1.91	Other	675	1,562
317	HEP.canalicular_transport.baseline	0.71	Nonsignificant	0.98	0.99	Other	199	477
318	EPI.ileal_enterocyte_absorptive.villus_tip	0.70	Nonsignificant	1.00	0.00	Other	4	3
319	DC.cDC2.pro_inflammatory	0.70	Nonsignificant	0.93	0.59	Other	3	5
320	HEP.canalicular_transport.pericentral_like_hypoxia	0.70	Nonsignificant	0.98	0.91	Other	326	8
321	DC.cDC2.migratory	0.70	Nonsignificant	0.93	0.71	Other	185	39
322	EPI.ileal_bile_transport.detox_transcytosis	0.70	Nonsignificant	—	0.00	Other	0	1
323	MONO.CD14.APC_like	0.67	Nonsignificant	6.38e-10	1.57	Other	1,686	2,493
324	EPI.skin_keratinocyte_basal.basement_anchoring	0.66	Nonsignificant	—	0.97	Other	0	0
325	EPI.tracheal_submucosal_gland.ductal_luminal	0.66	Nonsignificant	—	0.73	Other	0	0
326	EPI.tracheal_suprabasal.transitional_wound	0.63	Nonsignificant	—	0.00	Other	16	1
327	MONO.CD16.hepatic_mac_like	0.60	Nonsignificant	0.68	1.11	Other	803	117
328	EPI.pancreatic_acinar.adhesion_remodeling	0.60	Nonsignificant	1.00	0.26	Other	210	784
329	EPI.renal_distal_tubule.ciliated_remodelling	0.60	Nonsignificant	—	0.39	Other	0	0
330	B.germinal_center.LZ_memory_precursor	0.59	Nonsignificant	—	0.00	Other	0	0
331	HEP.canalicular_transport.ductular_like_transition	0.58	Nonsignificant	0.98	0.71	Other	400	87
332	B.germinal_center.DZ_S_phase	0.57	Nonsignificant	—	0.00	Other	0	0
333	EPI.pancreatic_acinar.metabolic_onecarbon	0.57	Nonsignificant	1.00	0.03	Other	287	328
334	EPI.renal_distal_tubule.stress	0.56	Nonsignificant	—	0.30	Other	0	0
335	HEP.acute_phase.stress_secretory	0.55	Nonsignificant	1.00	0.02	Other	26	3
336	FIB.skin_neurosecretory.baseline	0.53	Nonsignificant	—	0.00	Other	0	0
337	DC.cDC2.proliferative	0.53	Nonsignificant	—	0.00	Other	39	71
338	EPI.lung_club_secretory.canonical_surfactant	0.52	Nonsignificant	—	0.00	Other	74	104
339	FIB.skin_papillary.baseline	0.49	Nonsignificant	—	0.00	Other	0	0
340	EPI.salivary_serous_acinar.quiescent	0.49	Nonsignificant	1.00	0.02	Other	178	493
341	MONO.CD14.platelet_bound	0.48	Nonsignificant	0.07	1.34	Other	964	176
342	SMC.contractile	0.47	Nonsignificant	6.16e-04	1.63	Other	80	588
343	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.46	Nonsignificant	—	0.00	Other	0	0
344	EPI.renal_principal_cell.canonical_vasopressin	0.46	Nonsignificant	0.82	1.03	Other	2	0
345	EPI.renal_principal_cell.intercalated_like	0.43	Nonsignificant	0.82	0.88	Other	63	66
346	DC.cDC2.monocyte_like	0.39	Nonsignificant	0.93	0.70	Other	1,285	791
347	HEP.canalicular_transport.secretory_ERAD_UPR	0.38	Nonsignificant	0.98	0.49	Other	232	28
348	EC.liver_sinusoidal.secretory_lipoprotein	0.36	Nonsignificant	0.03	1.47	Other	120	70
349	EPI.alveolar_type_1.baseline	0.36	Nonsignificant	0.11	1.64	Other	8	0
350	DC.cDC2.lipid_metabolic	0.34	Nonsignificant	—	0.00	Other	0	0
351	MONO.CD16.patrolling	0.34	Nonsignificant	1.00	0.10	Other	797	216
352	EPI.renal_principal_cell.injury_repair	0.34	Nonsignificant	0.94	0.40	Other	26	9
353	EPI.renal_immature_ureteric_bud.defense_secretory	0.33	Nonsignificant	0.07	1.25	Other	45	76
354	MONO.CD14.inflammatory	0.31	Nonsignificant	0.63	1.17	Other	92	134
355	EPI.alveolar_type_2.injury_primed	0.30	Nonsignificant	1.00	0.00	Other	434	245
356	EC.capillary.angiogenic_tip	0.28	Nonsignificant	0.07	1.39	Other	186	218
357	EPI.skin_interfollicular_spinous.upper_lipid	0.28	Nonsignificant	—	1.51	Other	6	6
358	FIB.suburothelial.urothelial_interface	0.28	Nonsignificant	0.05	2.20	Other	9	8
359	FIB.suburothelial.inflammatory_prostanoid	0.26	Nonsignificant	—	0.32	Other	0	0
360	FIB.skin_tenogenic.baseline	0.26	Nonsignificant	—	0.00	Other	0	2
361	EPI.lung_multiciliated.mature_motile_cilia	0.25	Nonsignificant	—	0.00	Other	0	0
362	EPI.renal_distal_tubule.ion_transport	0.25	Nonsignificant	—	6.94e-17	Other	0	0
363	EPI.cervical_suprabasal.secretory_vesicle	0.24	Nonsignificant	—	0.00	Other	0	0
364	FIB.suburothelial.contractile_myofibroblast	0.23	Nonsignificant	—	0.00	Other	9	0
365	EPI.renal_intercalated_cell_type_A.PC_transitional	0.22	Nonsignificant	—	0.00	Other	203	407
366	EC.liver_sinusoidal.stress	0.21	Nonsignificant	—	0.54	Other	413	158
367	SMC.activated	0.21	Nonsignificant	1.00	0.73	Other	2	5
368	GRANU.neutrophil.primed_degranulation	0.20	Nonsignificant	—	0.64	Other	0	0
369	FIB.lung_alveolar.stress_interacting	0.20	Nonsignificant	—	0.97	Other	0	0
370	MAC.microglia_like.patrolling_adhesive	0.19	Nonsignificant	—	0.00	Other	0	0
371	FIB.suburothelial.homeostasis_matrix	0.19	Nonsignificant	0.72	0.65	Other	258	921
372	EPI.thymic_cortical.secretory_remodeling	0.19	Nonsignificant	—	1.23	Other	4	1
373	DC.pDC.immature_metabolic	0.19	Nonsignificant	0.11	1.64	Other	78	124
374	EC.lymphatic.activated	0.18	Nonsignificant	0.60	1.26	Other	47	73
375	EPI.salivary_duct_ion_transport.baseline	0.18	Nonsignificant	—	—	Other	0	0
376	EPI.tracheal_submucosal_gland.acinar_serous	0.18	Nonsignificant	—	0.00	Other	0	0
377	EC.lymphatic.baseline	0.17	Nonsignificant	0.60	1.18	Other	38	72
378	EPI.ectocervical_granular.inflammatory	0.17	Nonsignificant	—	1.15	Other	0	0
379	MAC.MDM.inflammatory_phagocytic	0.16	Nonsignificant	0.60	1.09	Other	199	52
380	GRANU.neutrophil.antiviral_endotoxin	0.15	Nonsignificant	—	0.00	Other	0	0
381	ASTRO.homeostatic	0.15	Nonsignificant	0.08	1.33	Other	200	431
382	EPI.salivary_myoepithelial.contractile_repair	0.15	Nonsignificant	—	0.64	Other	3	9
383	MONO.CD14.remodeling	0.14	Nonsignificant	0.99	0.97	Other	2,373	295
384	EC.liver_sinusoidal.inflammatory	0.14	Nonsignificant	—	0.11	Other	223	154
385	EC.lymphatic.tip_migratory	0.14	Nonsignificant	0.64	1.02	Other	23	37
386	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.12	Nonsignificant	—	0.00	Other	0	0
387	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.12	Nonsignificant	—	1.18	Other	39	82
388	EC.liver_sinusoidal.prostanoid	0.12	Nonsignificant	—	0.00	Other	11	64
389	FIB.neurolectin_mucosa.axon_responsive	0.11	Nonsignificant	0.61	0.95	Other	10	10
390	PLAT.megakaryocytic	0.11	Nonsignificant	—	0.00	Other	0	0
391	EPI.ectocervical_granular.immune_interact	0.11	Nonsignificant	—	0.32	Other	0	0
392	SMC.metabolic	0.11	Nonsignificant	1.00	0.32	Other	14	40
393	MONO.CD14.baseline	0.10	Nonsignificant	1.00	0.63	Other	2,268	76
394	MAC.MDM.APC_dendritic	0.10	Nonsignificant	0.60	1.13	Other	48	15
395	DC.pDC.poised_migratory	0.10	Nonsignificant	0.48	1.34	Other	54	95
396	FIB.hepatic_stellate_cell.contractile	0.10	Nonsignificant	—	1.15	Other	0	0
397	ASTRO.stress_acute	0.10	Nonsignificant	0.06	1.42	Other	60	56
398	EPI.salivary_myoepithelial.junctional_transport	0.10	Nonsignificant	0.86	1.11	Other	66	121
399	EPI.thymic_cortical.baseline	0.10	Nonsignificant	0.79	0.48	Other	185	386
400	FIB.perivascular_interface.vasomotor_tone	0.10	Nonsignificant	—	0.00	Other	0	0
401	EPI.salivary_myoepithelial.activated	0.09	Nonsignificant	0.86	0.80	Other	85	281
402	FIB.hepatic_stellate_cell.inflammatory	0.09	Nonsignificant	—	0.00	Other	0	0
403	NEU.EXC_CT.Ca2_sensor	0.09	Nonsignificant	—	1.32	Other	0	0
404	EPI.thymic_cortical.Notch_interface	0.09	Nonsignificant	—	0.00	Other	82	137
405	EPI.endocervical_secretory.secretory_translocon	0.09	Nonsignificant	—	0.67	Other	0	0
406	FIB.hepatic_stellate_cell.fibrogenic	0.09	Nonsignificant	—	0.00	Other	0	0
407	FIB.perivascular_interface.vascular_BM_remodelling	0.09	Nonsignificant	—	0.30	Other	0	0
408	FIB.neurolectin_mucosa.inflammatory	0.09	Nonsignificant	0.61	1.03	Other	52	110
409	CM.osmoprotection	0.08	Nonsignificant	1.00	1.20	Other	34	57
410	EPI.salivary_myoepithelial.baseline	0.08	Nonsignificant	0.86	0.54	Other	42	141
411	CM.sarcomere_actin_interface	0.08	Nonsignificant	1.00	1.02	Other	450	78
412	ASTRO.A2_reactive	0.08	Nonsignificant	0.98	0.85	Other	10	37
413	EC.lymphatic.scavenger	0.08	Nonsignificant	0.99	0.18	Other	203	257
414	EC.lymphatic.valve	0.08	Nonsignificant	—	0.00	Other	0	0
415	GRANU.neutrophil.tissue_patrolling	0.07	Nonsignificant	—	0.00	Other	0	0
416	MAC.resident_iron.stress_tolerogenic	0.07	Nonsignificant	—	0.93	Other	0	0
417	ASTRO.immature_lipid	0.07	Nonsignificant	0.98	1.07	Other	23	113
418	EC.capillary.inflammatory	0.07	Nonsignificant	0.13	1.21	Other	27	51
419	FIB.barrier_purinergic.lipid_secretory	0.07	Nonsignificant	—	0.48	Other	0	0
420	DC.cDC1.homeostatic_inhibitory	0.07	Nonsignificant	—	1.21	Other	0	0
421	EPI.skin_interfollicular_spinous.stress_UPR	0.07	Nonsignificant	—	0.75	Other	0	0
422	CM.anti_inflammatory	0.06	Nonsignificant	1.00	0.89	Other	424	1,503
423	DC.pDC.baseline	0.06	Nonsignificant	0.90	0.41	Other	88	123
424	MONO.CD14.cord_tolerance	0.06	Nonsignificant	0.63	1.06	Other	864	753
425	ASTRO.stress_mito	0.06	Nonsignificant	0.98	0.89	Other	47	110
426	FIB.neurolectin_mucosa.nerve_interface	0.06	Nonsignificant	—	0.00	Other	4	0
427	FIB.lung_alveolar.mito_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
428	ASTRO.A1_reactive	0.06	Nonsignificant	0.98	0.89	Other	433	394
429	CM.mechano_activated	0.05	Nonsignificant	1.00	1.15	Other	205	134
430	GRNLSA.lipid_hypoxia	0.05	Nonsignificant	0.75	1.07	Other	28	0
431	MUSC.baseline	0.05	Nonsignificant	0.58	1.31	Other	0	0
432	CM.baseline	0.05	Nonsignificant	1.00	0.76	Other	393	0
433	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.05	Nonsignificant	2.41e-03	1.23	Other	11	22
434	FIB.perivascular_interface.lipid_shuttle	0.05	Nonsignificant	—	0.00	Other	51	170
435	EPI.skin_interfollicular_spinous.baseline	0.05	Nonsignificant	0.98	1.14	Other	35	3
436	EC.capillary.stress	0.05	Nonsignificant	0.80	1.07	Other	44	36
437	MUSC.early_activation	0.05	Nonsignificant	0.65	1.09	Other	4	32
438	EC.capillary.activated	0.05	Nonsignificant	0.80	1.10	Other	2	5
439	MONO.CD14.repair_M2_like	0.05	Nonsignificant	1.00	0.72	Other	550	1,495
440	EPI.alveolar_type_1.activated	0.05	Nonsignificant	—	0.00	Other	0	0
441	NEU.EXC_SYT2.nuclear_reg	0.05	Nonsignificant	—	0.00	Other	0	0
442	FIB.neurolectin_mucosa.remodeling_repair	0.05	Nonsignificant	—	0.00	Other	4	2
443	GRNLSA.secretory_remodeling	0.05	Nonsignificant	0.01	1.43	Other	90	25
444	PERI.inflammatory	0.05	Nonsignificant	0.06	1.18	Other	40	77
445	EC.arterial.homeostatic	0.04	Nonsignificant	0.82	1.10	Other	24	3
446	EC.arterial.elastic	0.04	Nonsignificant	0.86	1.09	Other	22	45
447	CM.mito_proteostasis	0.04	Nonsignificant	1.00	0.62	Other	329	29
448	CM.translation_boost_RPL	0.04	Nonsignificant	1.00	0.65	Other	129	1
449	MAC.LAM.lipid_opsonization	0.04	Nonsignificant	0.06	1.19	Other	45	14
450	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.04	Nonsignificant	—	1.11	Other	29	88
451	MAC.resident_iron.APC_iron_sensing	0.04	Nonsignificant	0.66	1.04	Other	211	114
452	EPI.skin_interfollicular_spinous.early_differentiation	0.04	Nonsignificant	1.00	0.87	Other	89	19
453	EPI.skin_follicular_keratinizing.upper_infundibulum	0.04	Nonsignificant	—	0.00	Other	8	2
454	NEU.INH_VIP.LAMP5_hybrid	0.04	Nonsignificant	—	1.60	Other	1	9
455	EC.venous.quiescent_homeostatic	0.04	Nonsignificant	0.52	1.08	Other	456	360
456	CM.oxidative_phospho	0.04	Nonsignificant	1.00	0.70	Other	266	792
457	MUSC.quiescent_reservoir	0.04	Nonsignificant	0.65	1.04	Other	2	8
458	MAC.resident_repair.lipid_phagocytic	0.04	Nonsignificant	0.13	1.33	Other	228	604
459	ASTRO.synaptic_interaction	0.04	Nonsignificant	0.98	0.76	Other	76	334
460	EPI.skin_follicular_keratinizing.transit_amplifying	0.03	Nonsignificant	—	0.05	Other	21	49
461	MAC.MDM.LAM_like	0.03	Nonsignificant	0.60	1.05	Other	12	14
462	MAC.resident_iron.redox_metabolic	0.03	Nonsignificant	0.72	0.92	Other	4	4
463	NEU.INH_VIP.develop_niche	0.03	Nonsignificant	—	1.68	Other	0	0
464	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.03	Nonsignificant	—	0.61	Other	135	290
465	GRNLSA.chemokine_mechanosensory	0.03	Nonsignificant	0.77	0.97	Other	1	0
466	GRNLSA.cholesterol_mevalonate	0.03	Nonsignificant	0.77	0.92	Other	9	4
467	PERI.baseline	0.03	Nonsignificant	0.97	1.00	Other	39	66
468	EPI.skin_follicular_keratinizing.root_infundibulum	0.03	Nonsignificant	—	0.13	Other	0	0
469	NEU.EXC_IT.structural	0.03	Nonsignificant	0.51	1.23	Other	171	41
470	ASTRO.neuromodulatory	0.03	Nonsignificant	0.98	0.66	Other	34	172
471	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.02	Nonsignificant	—	0.00	Other	0	0
472	MAC.resident_iron.heme_catabolism	0.02	Nonsignificant	0.66	1.05	Other	30	51
473	GRNLSA.EMT_insulin_signaling	0.02	Nonsignificant	0.75	1.15	Other	47	84
474	MAC.resident_repair.antigen_presenting	0.02	Nonsignificant	0.86	1.03	Other	244	113
475	EC.liver_sinusoidal.hypoxia_metabolic	0.02	Nonsignificant	1.00	0.23	Other	183	107
476	DC.cDC1.cross_presenting	0.02	Nonsignificant	—	0.00	Other	0	0
477	FIB.interstitial.mesenchymal_regulator	0.02	Nonsignificant	0.41	1.14	Other	4	4
478	GRNLSA.stress_metabolic	0.02	Nonsignificant	—	0.31	Other	1	2
479	NEU.EXC_CT.remodeling	0.02	Nonsignificant	—	0.48	Other	23	1
480	MAC.MDM.complement_resolving	0.02	Nonsignificant	0.96	0.67	Other	440	860
481	EC.capillary.baseline	0.02	Nonsignificant	1.00	0.72	Other	246	560
482	SKM.type_2_fast.glycolytic_IIx_IIb	0.02	Nonsignificant	1.31e-03	1.22	Other	565	1,482
483	DC.cDC1.activated	0.02	Nonsignificant	—	0.00	Other	0	0
484	MAC.resident_repair.chemokine_angiocrine	0.01	Nonsignificant	0.86	0.97	Other	87	138
485	EC.arterial.angiogenic_tip	0.01	Nonsignificant	—	0.43	Other	30	37
486	EC.venous.remodeling_stalk	0.01	Nonsignificant	0.52	1.06	Other	559	566
487	EC.capillary.migratory	0.01	Nonsignificant	1.00	0.67	Other	181	509
488	CM.translation_boost_RPS	0.01	Nonsignificant	1.00	0.25	Other	69	16
489	EPI.skin_appendage_keratinocyte.transit_amplifying	0.01	Nonsignificant	—	0.00	Other	109	358
490	NEU.EXC_CT.projector	0.01	Nonsignificant	0.55	1.05	Other	87	26
491	MAC.kupffer.monocyte_like	0.01	Nonsignificant	—	0.00	Other	0	0
492	FIB.reticular.stromal_niche	0.01	Nonsignificant	0.37	1.15	Other	0	0
493	EC.capillary.postcap_venule	0.01	Nonsignificant	1.00	0.71	Other	355	261
494	EC.capillary.angiocrine	0.01	Nonsignificant	1.00	0.70	Other	250	630
495	MG.baseline	0.01	Nonsignificant	0.62	0.94	Other	16	5
496	EPI.renal_distal_tubule.repair	0.01	Nonsignificant	—	0.00	Other	34	102
497	EPI.skin_interfollicular_spinous.stress_oxidative	0.01	Nonsignificant	—	0.00	Other	0	0
498	EPI.renal_immature_ureteric_bud.osmoprotective	0.01	Nonsignificant	1.00	0.23	Other	126	44
499	OPC.premyelinating	9.62e-03	Nonsignificant	0.03	1.37	Other	185	12
500	MAC.LAM.anti_inflammatory	9.53e-03	Nonsignificant	0.06	1.16	Other	86	132
501	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	9.34e-03	Nonsignificant	—	1.15	Other	0	0
502	SCHWN.axon_contact_cardiac	9.21e-03	Nonsignificant	0.26	1.25	Other	18	63
503	DC.cDC1.baseline	9.20e-03	Nonsignificant	—	0.00	Other	0	0
504	MG.phagocytic_APC	8.84e-03	Nonsignificant	0.50	1.11	Other	25	8
505	CM.inflammatory	8.62e-03	Nonsignificant	—	0.00	Other	0	0
506	ASPC.proliferative	8.54e-03	Nonsignificant	0.46	1.29	Other	33	85
507	MUSC.activated_migratory	8.36e-03	Nonsignificant	1.00	0.00	Other	6	7
508	MAC.resident_repair.stress_iron	8.31e-03	Nonsignificant	0.86	0.99	Other	48	97
509	EC.arterial.inflammatory	7.93e-03	Nonsignificant	1.00	1.05	Other	63	50
510	ASPC.remodeling	7.83e-03	Nonsignificant	0.76	1.10	Other	106	354
511	MEL.neurotrophic_migratory	7.53e-03	Nonsignificant	—	1.74	Other	0	0
512	PERI.angiocrine	7.48e-03	Nonsignificant	1.00	0.77	Other	93	102
513	FIB.reticular.stress_metallothionein	7.35e-03	Nonsignificant	—	0.00	Other	3	32
514	EC.venous.cardiac_structural	7.25e-03	Nonsignificant	0.47	1.19	Other	102	229
515	EC.heart_remodeling.perivascular	7.21e-03	Nonsignificant	0.53	1.09	Other	124	408
516	FIB.tracheal_subepithelial.baseline	7.07e-03	Nonsignificant	—	0.00	Other	0	0
517	DC.cDC1.proliferative	7.06e-03	Nonsignificant	—	0.00	Other	0	0
518	EPI.renal_thick_ascending_limb.salt_sensing	6.64e-03	Nonsignificant	0.59	1.12	Other	73	103
519	ASTRO.hypoxia_angiogenic	6.52e-03	Nonsignificant	0.98	0.41	Other	5	18
520	EC.venous.baseline	6.48e-03	Nonsignificant	0.97	0.96	Other	346	807
521	MG.expanding	6.37e-03	Nonsignificant	0.50	1.22	Other	2	1
522	SKM.type_2_fast.oxidative_IIa	6.27e-03	Nonsignificant	0.26	1.06	Other	946	56
523	EPI.skin_interfollicular_spinous.inflammatory	6.23e-03	Nonsignificant	—	0.00	Other	0	0
524	EC.liver_sinusoidal.remodeling_lipotoxicity	6.17e-03	Nonsignificant	—	0.00	Other	90	58
525	FIB.transitioning.matrix_stress	5.94e-03	Nonsignificant	—	0.18	Other	47	138
526	ASPC.adipocyte_capillary_interface	5.87e-03	Nonsignificant	0.76	1.10	Other	21	54
527	EC.arterial.arteriole_interface	5.67e-03	Nonsignificant	1.00	0.97	Other	31	12
528	EPI.skin_keratinocyte_progenitor.activated_stress	5.08e-03	Nonsignificant	—	0.00	Other	0	0
529	MESO.baseline	5.04e-03	Nonsignificant	5.54e-03	1.37	Other	0	6
530	GRNLSA.p53_damage	4.80e-03	Nonsignificant	—	0.00	Other	13	10
531	MAC.LAM.inflammatory_APC	4.60e-03	Nonsignificant	0.22	1.06	Other	872	165
532	OPC.proliferative_immune_interact	4.60e-03	Nonsignificant	0.89	0.88	Other	180	373
533	FIB.interstitial.immune_interact	4.11e-03	Nonsignificant	1.00	1.01	Other	12	1
534	OPC.homeostatic	3.66e-03	Nonsignificant	0.89	0.79	Other	394	160
535	OLG.stress	3.53e-03	Nonsignificant	0.63	1.09	Other	232	8
536	MAC.resident_repair.ECM_stromal_crosstalk	3.47e-03	Nonsignificant	0.89	0.87	Other	95	158
537	ASPC.activated	3.38e-03	Nonsignificant	0.76	1.00	Other	164	162
538	EPI.skin_interfollicular_spinous.transition_basal	3.22e-03	Nonsignificant	1.00	0.12	Other	100	127
539	CHOND.remodeling	3.07e-03	Nonsignificant	—	1.26	Other	5	0
540	ASPC.niche_keeping_progenitor	3.02e-03	Nonsignificant	0.83	0.95	Other	52	219
541	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	2.91e-03	Nonsignificant	0.85	0.86	Other	33	34
542	EC.venous.adipose_lipid	2.85e-03	Nonsignificant	0.52	1.08	Other	254	476
543	EC.heart_remodeling.remodeling_stalk	2.83e-03	Nonsignificant	0.81	1.08	Other	33	111
544	MEL.dedifferentiated_migratory	2.73e-03	Nonsignificant	—	0.44	Other	0	0
545	SCHWN.translation_boost	2.67e-03	Nonsignificant	—	0.00	Other	8	1
546	ASPC.secretory	2.67e-03	Nonsignificant	0.76	1.01	Other	76	5
547	FIB.interstitial.remodeling	2.57e-03	Nonsignificant	1.00	0.94	Other	31	9
548	EPI.skin_interfollicular_spinous.proliferative	2.55e-03	Nonsignificant	—	0.00	Other	0	0
549	EPI.skin_hair_follicle_bulge.quiescent	2.50e-03	Nonsignificant	0.96	0.31	Other	56	69
550	GRNLSA.proliferative_migratory	2.49e-03	Nonsignificant	0.96	0.68	Other	248	292
551	ASPC.preadipocyte_lipid_primed	2.41e-03	Nonsignificant	0.76	1.00	Other	331	129
552	MESO.secretory_structural	2.29e-03	Nonsignificant	—	0.29	Other	0	0
553	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	2.26e-03	Nonsignificant	0.85	0.64	Other	7	16
554	EC.arterial.arteriole_gas_exchange	2.20e-03	Nonsignificant	1.00	0.81	Other	238	131
555	FIB.reticular.ECM_builder	2.16e-03	Nonsignificant	—	0.10	Other	0	0
556	NEU.INH_VIP.nuclear_reg	2.15e-03	Nonsignificant	—	0.82	Other	20	4
557	EPI.endocervical_secretory.squamous_barrier	2.06e-03	Nonsignificant	—	0.00	Other	0	0
558	ASPC.baseline	2.05e-03	Nonsignificant	0.76	0.99	Other	363	170
559	SCHWN.reactive_inflammatory	2.03e-03	Nonsignificant	—	0.00	Other	0	0
560	MAC.kupffer.fibrogenic	1.77e-03	Nonsignificant	—	0.95	Other	0	0
561	NEU.EXC_IT.adhesion	1.73e-03	Nonsignificant	1.00	1.05	Other	252	108
562	MESO.activated_migratory	1.61e-03	Nonsignificant	—	0.00	Other	0	0
563	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.47e-03	Nonsignificant	—	0.97	Other	0	0
564	EC.arterial.mito_contact	1.41e-03	Nonsignificant	1.00	0.80	Other	14	5
565	FIB.adventitial.adhesion_lipid	1.31e-03	Nonsignificant	0.86	1.13	Other	58	209
566	FIB.reticular.immune_interface	1.21e-03	Nonsignificant	—	0.00	Other	1	6
567	EC.venous.activated	9.77e-04	Nonsignificant	0.97	0.84	Other	247	752
568	ASPC.inflammatory	8.77e-04	Nonsignificant	0.76	1.03	Other	21	61
569	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	8.40e-04	Nonsignificant	—	0.00	Other	0	0
570	NEU.EXC_IT.neuromodulated	7.13e-04	Nonsignificant	1.00	0.83	Other	176	116
571	OLG.regulatory_activated	6.56e-04	Nonsignificant	0.63	1.15	Other	196	614
572	MESO.antiviral	6.55e-04	Nonsignificant	—	0.00	Other	3	8
573	FIB.transitioning.motility_remodelling	6.40e-04	Nonsignificant	—	0.31	Other	0	0
574	MAC.resident_cardiac.antigen_presenting	6.02e-04	Nonsignificant	0.40	1.11	Other	52	27
575	EPI.ectocervical_granular.secretory_apocrine	5.51e-04	Nonsignificant	—	0.00	Other	0	0
576	CHOND.articular_collagen	5.45e-04	Nonsignificant	0.75	1.01	Other	551	266
577	ASPC.stem_like_progenitor	5.42e-04	Nonsignificant	0.76	0.99	Other	300	842
578	FIB.barrier_purinergic.stress_GF_binding	5.33e-04	Nonsignificant	—	0.00	Other	0	0
579	EC.arterial.ion_pump	5.19e-04	Nonsignificant	1.00	0.59	Other	3	2
580	CHOND.activated_fibro_like	5.16e-04	Nonsignificant	0.75	1.01	Other	531	188
581	NEU.INH_VIP.cannabinoid	5.12e-04	Nonsignificant	—	0.28	Other	0	0
582	NEU.EXC_CT.Ca2_signaling	4.47e-04	Nonsignificant	—	0.00	Other	68	17
583	EC.arterial.metabolic	4.26e-04	Nonsignificant	1.00	0.47	Other	195	159
584	EPI.renal_thick_ascending_limb.barrier_repair	4.20e-04	Nonsignificant	0.90	1.02	Other	141	284
585	EPI.ectocervical_granular.proliferative_basal	3.76e-04	Nonsignificant	—	0.00	Other	0	0
586	OLG.myelinating_mature	3.66e-04	Nonsignificant	0.99	1.03	Other	363	94
587	EPI.skin_hair_follicle_bulge.anagen_growth	3.62e-04	Nonsignificant	—	0.00	Other	0	0
588	FIB.adventitial.inflammatory_activated	3.57e-04	Nonsignificant	0.86	1.06	Other	100	473
589	EPI.renal_thick_ascending_limb.canonical_salt_transporter	3.55e-04	Nonsignificant	0.59	1.09	Other	322	317
590	MAC.kupffer.tolerogenic	3.36e-04	Nonsignificant	—	0.31	Other	45	49
591	FIB.transitioning.secretory_procollagen	3.28e-04	Nonsignificant	—	0.61	Other	0	0
592	FIB.interstitial.lipid_matrix	3.12e-04	Nonsignificant	1.00	0.83	Other	258	191
593	NEU.INH_VIP.enkephalinergic	3.03e-04	Nonsignificant	—	0.63	Other	0	0
594	MAC.LAM.antimicrobial	2.88e-04	Nonsignificant	0.81	0.95	Other	389	93
595	MAC.resident_iron.heme_recycling	2.87e-04	Nonsignificant	—	0.00	Other	30	37
596	NEU.INH_PVALB.chandelier	2.24e-04	Nonsignificant	0.45	1.09	Other	19	16
597	NEU.EXC_IT.callosal	1.92e-04	Nonsignificant	1.00	0.65	Other	286	119
598	MAC.kupffer.inflammatory	1.76e-04	Nonsignificant	—	0.00	Other	7	4
599	EPI.skin_keratinocyte_proliferating.detox_repair	1.56e-04	Nonsignificant	—	0.00	Other	0	0
600	MAC.proliferating.stress	1.45e-04	Nonsignificant	—	0.00	Other	87	136
601	MAC.alveolar.capillary_interacting	1.39e-04	Nonsignificant	0.27	1.25	Other	113	181
602	NEU.INH_LAMP5.projecting	1.38e-04	Nonsignificant	—	1.16	Other	0	0
603	NEU.INH_PVALB.nuclear_reg	1.35e-04	Nonsignificant	0.40	1.22	Other	25	12
604	NEU.EXC_IT.guidance	1.28e-04	Nonsignificant	1.00	0.59	Other	274	63
605	MAC.kupffer.metabolic	1.24e-04	Nonsignificant	—	0.07	Other	25	36
606	PERI.cardiac_skeletal	1.18e-04	Nonsignificant	1.00	0.05	Other	313	630
607	EPI.renal_thick_ascending_limb.remodeling	1.12e-04	Nonsignificant	0.90	0.85	Other	152	92
608	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	1.10e-04	Nonsignificant	—	1.24	Other	0	0
609	MEL.stress_glucocorticoid	1.10e-04	Nonsignificant	1.00	0.89	Other	11	34
610	HEP.pericentral_lipoprotein.ApoB_coagulation	1.04e-04	Nonsignificant	—	0.67	Other	0	0
611	CHOND.angiogenic	9.12e-05	Nonsignificant	—	0.57	Other	0	0
612	MAC.proliferating.DNA_replication	9.01e-05	Nonsignificant	0.67	0.90	Other	3	6
613	NEU.INH_PVALB.metabotropic	8.45e-05	Nonsignificant	—	0.00	Other	0	0
614	NEU.EXC_NTNG1.synaptic	8.44e-05	Nonsignificant	—	0.67	Other	0	0
615	MEL.secretory_quiescent	7.94e-05	Nonsignificant	1.00	0.81	Other	19	13
616	FIB.transitioning.ISG_primed_interface	7.90e-05	Nonsignificant	—	0.00	Other	17	80
617	FIB.adventitial.PI16_matrix	7.00e-05	Nonsignificant	0.86	1.07	Other	70	90
618	NEU.INH_LAMP5.exc_inh_balance	6.51e-05	Nonsignificant	—	0.00	Other	46	2
619	HEP.pericentral_lipoprotein.UPR_redox	6.26e-05	Nonsignificant	—	0.00	Other	0	0
620	NEU.EXC_IT.transitional	6.00e-05	Nonsignificant	1.00	0.49	Other	237	142
621	MAC.LAM.lipid_phagocytosis	5.85e-05	Nonsignificant	0.81	0.90	Other	369	328
622	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	4.88e-05	Nonsignificant	0.27	1.20	Other	2	9
623	MAC.resident_cardiac.inflammatory_reparative	4.82e-05	Nonsignificant	0.73	1.05	Other	31	96
624	EPI.skin_sebaceous_duct_luminal.immune_interface	4.69e-05	Nonsignificant	—	0.92	Other	0	0
625	EPI.salivary_intercalated_defense.inflammatory	4.40e-05	Nonsignificant	1.00	0.18	Other	152	360
626	FIB.interstitial.mesenchymal_APC	4.12e-05	Nonsignificant	1.00	0.57	Other	81	33
627	NEU.EXC_NTNG1.nuclear_reg	3.94e-05	Nonsignificant	—	0.00	Other	0	0
628	EPI.skin_keratinocyte_basal.transit_amplifying	3.76e-05	Nonsignificant	—	0.00	Other	0	0
629	OLG.regulatory	3.10e-05	Nonsignificant	0.99	0.98	Other	353	73
630	NEU.INH_VIP.matrix	2.94e-05	Nonsignificant	—	0.22	Other	24	77
631	MAC.kupffer.stress	2.66e-05	Nonsignificant	0.99	0.38	Other	9	3
632	ADIPO.thermogenic	2.47e-05	Nonsignificant	—	1.09	Other	0	0
633	EPI.renal_thick_ascending_limb.cation_flux	2.33e-05	Nonsignificant	0.90	0.88	Other	57	95
634	EC.heart_remodeling.angiocrine	2.30e-05	Nonsignificant	1.00	0.58	Other	182	525
635	FIB.barrier_secretory.homeostasis	2.11e-05	Nonsignificant	—	0.43	Other	0	0
636	NEU.INH_VIP.serotonergic	2.08e-05	Nonsignificant	—	0.00	Other	9	2
637	EC.heart_remodeling.remodeling_secretory	1.82e-05	Nonsignificant	1.00	0.81	Other	605	1,341
638	EC.heart_remodeling.activated_acute	1.74e-05	Nonsignificant	1.00	0.95	Other	102	186
639	CHOND.pro_inflammatory	1.73e-05	Nonsignificant	0.99	0.63	Other	181	351
640	ASPC.mesothelial_like	1.49e-05	Nonsignificant	0.89	0.66	Other	143	486
641	NEU.INH_PVALB.neuromodulatory	1.34e-05	Nonsignificant	—	0.00	Other	0	0
642	NEU.INH_VIP.excitatory_coupled	1.22e-05	Nonsignificant	—	0.00	Other	13	0
643	MESO.activated_stress	1.04e-05	Nonsignificant	—	0.00	Other	0	0
644	NEU.INH_PVALB.fastspike	9.83e-06	Nonsignificant	—	0.00	Other	24	22
645	MAC.resident_cardiac.phagocytic_homeostasis	8.50e-06	Nonsignificant	1.00	0.71	Other	564	1,221
646	FIB.interstitial.stress_secretory	8.17e-06	Nonsignificant	1.00	0.43	Other	92	56
647	MAC.LAM.perivascular_angiocrine	7.03e-06	Nonsignificant	—	0.00	Other	53	138
648	FIB.barrier_secretory.remodeling	5.97e-06	Nonsignificant	—	0.00	Other	0	0
649	MAC.alveolar.lipid_autophagy	5.83e-06	Nonsignificant	—	0.22	Other	35	44
650	NEU.INH_PVALB.serotonergic	4.87e-06	Nonsignificant	—	0.00	Other	0	0
651	EPI.salivary_duct_excretory.baseline	4.42e-06	Nonsignificant	0.51	1.10	Other	23	57
652	FIB.adventitial.baseline	3.66e-06	Nonsignificant	0.99	0.83	Other	157	278
653	FIB.adventitial.mechano_chemo_sensing	3.02e-06	Nonsignificant	0.99	0.87	Other	135	524
654	MEL.mature_oxidative_traffic	2.62e-06	Nonsignificant	1.00	0.20	Other	247	285
655	EPI.salivary_duct_excretory.stress	2.37e-06	Nonsignificant	0.51	1.06	Other	33	68
656	FIB.adventitial.complement_angiocrine	2.29e-06	Nonsignificant	0.99	0.68	Other	153	684
657	MAC.alveolar.inflammatory	2.03e-06	Nonsignificant	0.87	1.03	Other	208	312
658	NEU.INH_VIP.regulatory_remodeling	1.88e-06	Nonsignificant	—	0.00	Other	6	1
659	ADIPO.hypoxia_remodelling	1.43e-06	Nonsignificant	—	0.00	Other	29	105
660	FIB.adventitial.mito_secretory	1.32e-06	Nonsignificant	0.99	0.75	Other	21	7
661	EPI.skin_sebaceous_duct_luminal.detox_repair	1.07e-06	Nonsignificant	0.97	0.48	Other	137	94
662	EPI.skin_sweat_duct_keratinocyte.barrier	9.53e-07	Nonsignificant	—	0.16	Other	0	0
663	OLG.myelinating_stress	8.65e-07	Nonsignificant	0.99	0.82	Other	232	62
664	EC.heart_remodeling.translation_boost	7.32e-07	Nonsignificant	—	0.00	Other	0	0
665	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	4.05e-07	Nonsignificant	—	0.00	Other	0	0
666	EPI.skin_hair_follicle_companion.activated_migratory	3.57e-07	Nonsignificant	—	0.00	Other	0	0
667	OLG.vesicle_trafficking	2.98e-07	Nonsignificant	0.99	0.77	Other	124	10
668	OLG.reactive_repair	2.66e-07	Nonsignificant	0.99	0.67	Other	385	385
669	NEU.INH_LAMP5.rosehip	2.36e-07	Nonsignificant	—	0.00	Other	0	0
670	NEU.INH_VIP.canonical_disinhibitory	1.85e-07	Nonsignificant	1.00	0.30	Other	59	38
671	NEU.INH_VIP.opioid	9.62e-08	Nonsignificant	—	0.00	Other	50	9
672	EC.heart_remodeling.capillary_metabolic	9.44e-08	Nonsignificant	1.00	0.37	Other	54	414
673	EPI.salivary_intercalated_defense.basal_EMT	4.70e-08	Nonsignificant	—	0.00	Other	0	0
674	NEU.INH_LAMP5.glial_interface	3.46e-08	Nonsignificant	—	0.00	Other	0	0
675	EPI.skin_sweat_duct_keratinocyte.signal_gate	3.19e-08	Nonsignificant	—	0.43	Other	43	26
676	ASPC.signal_integrator	2.15e-08	Nonsignificant	—	0.00	Other	0	0
677	FIB.adventitial.activated_remodelling	1.63e-08	Nonsignificant	—	0.00	Other	141	319
678	ADIPO.inflammatory	1.04e-08	Nonsignificant	—	0.28	Other	0	0
679	EPI.skin_keratinocyte_basal.spinous_transition	5.52e-09	Nonsignificant	—	0.00	Other	0	0
680	MAC.alveolar.biosynthetic_sterol_heme	4.93e-09	Nonsignificant	0.87	0.84	Other	347	40
681	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	3.55e-09	Nonsignificant	—	0.00	Other	0	0
682	GRNLSA.angiocrine_mechanosensory	2.20e-09	Nonsignificant	—	0.00	Other	0	0
683	EPI.skin_sweat_duct_keratinocyte.repair	1.97e-09	Nonsignificant	—	0.00	Other	0	0
684	MAC.alveolar.stress_metabolic	1.72e-09	Nonsignificant	0.87	0.79	Other	116	148
685	MAC.alveolar.scavenging_endocytic	1.01e-09	Nonsignificant	—	0.00	Other	140	283
686	EPI.skin_sweat_duct_keratinocyte.proliferative_S	3.77e-11	Nonsignificant	—	0.00	Other	0	0
687	ADIPO.immature	1.31e-11	Nonsignificant	—	0.00	Other	24	40
688	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	2.69e-12	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

384 unique genes. Showing 1–384. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
MICB	01-High	0.80	19.18	G1	C1	—	T.CD8_transitional (Tier: specific) B.naive.restrained (Tier: specific) B.naive.metabolic (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	43 cells — complete matches	294	633
ENSG00000285647	01-High	0.80	20.96	G1	C1	—	—	—	364	611
ENSG00000271581	01-High	0.76	16.95	G1	C1	—	—	—	348	596
ENSG00000298396	01-High	0.75	18.99	G1	C1	—	—	—	295	527
ENSG00000288813	01-High	0.75	18.71	G1	C1	—	—	—	295	527
ENSG00000298426	01-High	0.74	20.21	G1	C1	—	—	—	317	607
HLA-C	01-High	0.72	20.66	G1	C1	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	76 cells — complete matches	738	1,070
HCP5	01-High	0.72	20.49	G1	C1	—	—	—	510	867
PSMB9	01-High	0.72	18.47	G1	C1	—	—	21 cells — complete matches	227	422
TAP2	01-High	0.69	18.55	G1	C1	—	—	10 cells — complete matches	198	364
ENSG00000289047	01-High	0.67	22.24	G1	C1	—	—	—	248	377
ENSG00000250264	01-High	0.66	15.99	G1	C1	—	—	—	198	364
PSMB8-AS1	01-High	0.66	12.41	G1	C1	—	T.CD8_transitional (Tier: specific) B.age_associated.migratory (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant)	10 cells — complete matches	204	380
H2AC13	01-High	0.65	14.40	G1	C1	—	—	—	104	183
ENSG00000289406	01-High	0.64	13.05	G1	C1	—	—	—	201	390
BAG6	01-High	0.63	13.36	G1	C1	—	—	MONO.CD16.inflammatory (L2)	73	116
BRD2	01-High	0.63	13.70	G1	C1	EPI.colonic_tuft.activated (L2), T.CD4_Trm.activated (L2)	EPI.colonocyte.crypt_progenitor (Tier: relevant)	13 cells — complete matches	256	441
HLA-B	01-High	0.63	20.03	G1	C1	EC.heart_remodeling.remodeling_stalk (L2), EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), FIB.skin_sheath.ECM_immune (L2), OPC.proliferative_immune_interact (L2), SMC.metabolic (L2)	B_cell (Tier: specific) T_cell (Tier: specific) B.memory (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD8_Trm (Tier: specific) B.naive.activated (Tier: specific) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	130 cells — complete matches	493	836
ENSG00000223837	01-High	0.62	12.38	G1	C1	—	—	—	198	339
ENSG00000263756	01-High	0.61	9.30	G1	C1	—	—	—	41	69
LTA	01-High	0.61	9.30	G1	C1	—	T_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Treg (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) B.naive.activated (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_transitional (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.metabolic (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	105 cells — complete matches	226	418
REST	01-High	0.59	4.84	G1	C1	—	—	—	30	88
BTN3A2	01-High	0.59	7.29	G1	C1	—	—	6 cells — complete matches	124	241
H2AC16	01-High	0.59	14.82	G1	C1	—	—	—	96	183
H2BC13	01-High	0.58	14.05	G1	C1	—	—	—	8	21
ENSG00000233902	01-High	0.57	9.30	G1	C1	—	—	—	150	247
PTPN22	01-High	0.57	14.16	G1	C1	—	T_cell (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Treg (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD8_Trm (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.memory.migratory (Tier: relevant) ILC2.quiescent (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) NK.cytokine_quiescent (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	97 cells — complete matches	73	148
ENSG00000290055	01-High	0.55	8.24	G1	C1	—	—	—	168	252
AP4B1-AS1	01-High	0.55	13.48	G1	C1	—	T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) ILC2.quiescent (Tier: relevant) NK.cytokine_quiescent (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	34 cells — complete matches	73	147
SKIC2	01-High	0.54	9.30	G1	C1	—	—	—	63	108
VARS1	01-High	0.52	9.30	G1	C1	—	—	—	28	56
DCLRE1B	01-High	0.51	14.08	G1	C1	—	T.CD4_transitional (Tier: relevant) NK.cytokine_quiescent (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant)	26 cells — complete matches	73	148
AP4B1	01-High	0.51	13.63	G1	C1	—	B.naive.restrained (Tier: specific) B.naive.remodeling (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	9 cells — complete matches	72	150
ABCF1	01-High	0.51	5.70	G1	C1	—	—	—	37	84
RSBN1	01-High	0.50	12.74	G1	C1	—	B.age_associated.migratory (Tier: relevant)	B.age_associated.migratory (L2), B.naive.receptor_recycle (L2), T.CD8_Tcm.gut_homing (L2)	71	146
BCL2L15	01-High	0.50	13.18	G1	C1	—	T.CD4_transitional.primed_helper_effector (Tier: relevant)	29 cells — complete matches	72	147
C6orf136	01-High	0.50	5.69	G1	C1	—	T.CD8_Tem.signaling_turnover (Tier: relevant)	T.CD8_Tem.signaling_turnover (L2)	174	338
HIPK1-AS1	01-High	0.49	13.58	G1	C1	—	B.age_associated.migratory (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	23 cells — complete matches	72	153
PHTF1	01-High	0.49	14.45	G1	C1	—	B.naive.purinergic (Tier: specific) T.CD8_Tcm.effector_bias (Tier: relevant)	6 cells — complete matches	63	136
HIPK1	01-High	0.48	12.36	G1	C1	—	ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant)	29 cells — complete matches	72	153
OLFML3	01-High	0.46	9.23	G1	C1	EPI.pancreatic_ductal_progenitor.baseline (L2), MG.baseline (L2)	EPI.colonic_enteroendocrine.progenitor (Tier: relevant)	95 cells — complete matches	72	147
MIR6891	02-Medium	0.73	21.93	G1	C2	—	—	—	474	812
MICB-DT	02-Medium	0.67	13.86	G1	C2	—	—	—	131	286
HLA-DQB1	02-Medium	0.66	20.97	G1	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant)	133 cells — complete matches	703	1,314
ENSG00000309733	02-Medium	0.65	18.05	G1	C2	—	—	—	468	929
PSMB8	02-Medium	0.65	16.77	G1	C2	—	—	5 cells — complete matches	200	385
TRIM26	02-Medium	0.64	18.41	G1	C2	—	T.CD8_Tcm.effector_bias (Tier: relevant)	8 cells — complete matches	69	112
ENSG00000303029	02-Medium	0.64	17.71	G1	C2	—	—	—	234	380
VARS2	02-Medium	0.63	20.60	G1	C2	—	T.CD4_Treg (Tier: specific) B.naive.activated (Tier: specific)	11 cells — complete matches	62	90
PSORS1C1	02-Medium	0.63	24.61	G1	C2	—	—	26 cells — complete matches	152	355
ENSG00000289559	02-Medium	0.63	22.66	G1	C2	—	—	—	131	232
POU5F1	02-Medium	0.61	18.96	G1	C2	induced_pluripotent_stem_cell (L1), IPSC.induced_pluripotent_stem_cell (L1S), IPSC.canonical_pluripotent (L2), IPSC.endoderm_primed (L2)	IPSC.stress (Tier: relevant)	10 cells — complete matches	107	259
MICA-AS1	02-Medium	0.61	18.99	G1	C2	—	—	—	210	470
ENSG00000302994	02-Medium	0.61	20.19	G1	C2	—	—	—	354	697
ENSG00000307907	02-Medium	0.60	15.32	G1	C2	—	—	—	489	1,000
HLA-DOB	02-Medium	0.60	21.31	G2	C2	—	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant)	64 cells — complete matches	135	235
C2	02-Medium	0.60	18.18	G1	C2	EPI.alveolar_type_2.baseline_surfactant (L2), EPI.alveolar_type_2.stress_response (L2), HEP.pericentral_lipoprotein.ApoB_coagulation (L2)	T.CD8_Trm.inflammatory (Tier: relevant)	49 cells — complete matches	61	83
TAP1	02-Medium	0.59	18.47	G1	C2	EPI.thymic_cortical.baseline (L2)	—	ASPC.inflammatory (L2), GRANU.neutrophil.antiviral_endotoxin (L2), HEP.periportal_metabolic.acute_phase_barrier (L2)	201	382
MICA	02-Medium	0.59	16.96	G1	C2	—	—	7 cells — complete matches	277	593
HLA-DRB1	02-Medium	0.59	18.44	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), FIB.reticular.immune_interface (L2), MAC.resident_cardiac.antigen_presenting (L2), MAC.resident_repair.antigen_presenting (L2), MG.phagocytic_APC (L2), MONO.CD14.APC_like (L2), NK.adaptive_axis_baseline (L2), NK.adaptive_biosynthetic_primed (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Tfh.effector_migratory (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	203 cells — complete matches	565	1,192
NOTCH4	02-Medium	0.59	15.49	G1	C2	—	—	36 cells — complete matches	143	264
TRIM31	02-Medium	0.58	16.00	G1	C2	EPI.colonocyte.distal_absorptive (L2)	EPI.colonocyte (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific)	30 cells — complete matches	82	107
HLA-DOA	02-Medium	0.58	12.60	G1	C2	—	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant)	88 cells — complete matches	225	407
ENSG00000296065	02-Medium	0.58	18.74	G1	C2	—	—	—	130	282
H2AC14	02-Medium	0.57	13.81	G2	C1	—	—	—	0	0
HLA-DQA1	02-Medium	0.57	17.24	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), MAC.resident_iron.APC_iron_sensing (L2), MONO.CD14.APC_like (L2), MONO.CD16.hepatic_mac_like (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	159 cells — complete matches	608	1,232
H2BC15	02-Medium	0.56	12.60	G2	C1	—	—	—	0	0
HLA-DMA	02-Medium	0.56	16.35	G1	C2	MONO.CD16.hepatic_mac_like (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD8_transitional.APC_like (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant)	97 cells — complete matches	226	330
ENSG00000288587	02-Medium	0.56	14.15	G1	C2	—	—	—	257	555
ENSG00000299747	02-Medium	0.55	19.82	G1	C2	—	—	—	346	745
LINC00243	02-Medium	0.55	18.38	G2	C1	—	T_cell (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	78 cells — complete matches	192	416
H4C12	02-Medium	0.55	12.95	G2	C1	—	—	—	0	0
HCG18	02-Medium	0.54	17.01	G1	C2	—	B.naive.purinergic (Tier: specific) ILC2.quiescent (Tier: relevant)	4 cells — complete matches	45	77
HCG20	02-Medium	0.54	19.42	G1	C2	EPI.ectocervical_granular.inflammatory (L2), EPI.pancreatic_acinar.inflammatory_regenerative (L2)	EPI.colonocyte (Tier: specific) EPI.colonocyte.goblet_interface (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	38 cells — complete matches	183	351
CCHCR1	02-Medium	0.54	18.14	G1	C2	—	T.CD4_Tem (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	13 cells — complete matches	146	317
AIF1	02-Medium	0.54	13.77	G1	C2	IPSC.mesodermal_primed (L2), T.CD4_Tcm.stress (L2)	T_cell (Tier: specific) T.CD8_Tcm (Tier: specific) ILC2.quiescent (Tier: relevant)	118 cells — complete matches	433	801
HLA-DRA	02-Medium	0.54	16.89	G1	C2	B_cell (L1), dendritic_cell (L1), DC.mig (L1S), EC.capillary.postcap_venule (L2), EPI.renal_distal_tubule.stress (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MAC.resident_repair.antigen_presenting (L2), MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	194 cells — complete matches	693	1,237
ZDHHC20P1	02-Medium	0.54	10.42	G2	C1	—	—	—	140	226
HLA-DPA1	02-Medium	0.54	7.39	G1	C2	EC.capillary.postcap_venule (L2), MAC.resident_cardiac.antigen_presenting (L2), MAC.resident_repair.antigen_presenting (L2), MONO.CD14.APC_like (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	162 cells — complete matches	287	545
TRIM27	02-Medium	0.54	12.37	G1	C2	—	—	T.CD4_Tfh (L1S), B.naive.receptor_recycle (L2), MAC.resident_repair.antigen_presenting (L2)	44	103
HLA-F-AS1	02-Medium	0.54	10.16	G2	C1	—	—	—	199	357
SFTA2	02-Medium	0.54	20.11	G1	C2	EPI.alveolar_type_1.baseline (L2), EPI.lung_club_secretory.canonical_surfactant (L2)	T.CD4_cytotoxic.NK_adapted (Tier: relevant)	23 cells — complete matches	53	143
PSORS1C3	02-Medium	0.54	16.17	G1	C2	—	—	—	124	315
ENSG00000293879	02-Medium	0.54	17.39	G1	C2	—	—	—	152	319
MUCL3	02-Medium	0.53	15.83	G1	C2	—	—	—	1	1
ZFP57	02-Medium	0.53	10.85	G1	C2	—	B.naive (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.remodeling (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	34 cells — complete matches	59	109
FLOT1	02-Medium	0.53	9.99	G1	C2	—	—	EC.arterial.ion_pump (L2)	278	593
IER3	02-Medium	0.53	9.99	G1	C2	DC.cDC2.pro_inflammatory (L2), EPI.pancreatic_acinar.inflammatory_regenerative (L2), EPI.salivary_myoepithelial.activated (L2), EPI.skin_follicular_keratinizing.transit_amplifying (L2), FIB.barrier_purinergic.stress_GF_binding (L2), FIB.reticular.stress_metallothionein (L2), HEP.canalicular_transport.secretory_ERAD_UPR (L2), MAC.kupffer.inflammatory (L2), PC.IgG_systemic.interacting (L2), SCHWN.reactive_inflammatory (L2), T.CD4_Trm.activated (L2), T.CD8_Trm.inflammatory (L2)	EPI.colonocyte (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) EPI.colonocyte.goblet_interface (Tier: relevant) NK.cytokine_tissue_activation (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	85 cells — complete matches	247	484
HLA-L	02-Medium	0.53	14.63	G1	C2	—	—	—	76	108
HLA-L.2	02-Medium	0.53	14.63	G1	C2	—	—	—	76	108
BAK1	02-Medium	0.53	8.85	G2	C1	—	T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	12 cells — complete matches	19	57
H3C11	02-Medium	0.52	12.98	G2	C1	—	—	—	7	15
ENSG00000299769	02-Medium	0.52	16.90	G1	C2	—	—	—	333	727
H1-5	02-Medium	0.52	14.75	G2	C1	—	—	—	0	0
H2BC14	02-Medium	0.52	13.97	G2	C1	—	—	—	0	0
MIR6833	02-Medium	0.52	9.30	G1	C2	—	—	—	108	133
HLA-DQA2	02-Medium	0.52	18.13	G1	C2	T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	127 cells — complete matches	173	495
ZNF165	02-Medium	0.52	11.07	G2	C1	EPI.hepatic_ductular_cholangiocyte.stress (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) B.age_associated (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.metabolic (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.repair_actin_junction (Tier: relevant) ILC2.quiescent (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	93 cells — complete matches	19	48
GTF2H4	02-Medium	0.52	19.36	G2	C2	—	B.naive.antigen_presenting_ready (Tier: relevant)	4 cells — complete matches	61	160
H4C11	02-Medium	0.52	12.11	G2	C1	—	—	—	12	18
HLA-DPB1	02-Medium	0.52	5.52	G1	C2	EC.capillary.postcap_venule (L2), MAC.resident_repair.antigen_presenting (L2), MONO.CD14.APC_like (L2), NK.adaptive_classII_inhibitory (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_transitional.APC_like (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	137 cells — complete matches	293	562
TRIM38	02-Medium	0.52	3.99	G1	C2	—	B.naive.activated (Tier: specific) B.age_associated.migratory (Tier: relevant)	10 cells — complete matches	134	252
HCG27	02-Medium	0.52	20.74	G2	C2	—	T.CD4_Tcm.effector_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	37 cells — complete matches	119	287
H3C12	02-Medium	0.51	13.18	G2	C1	—	—	—	1	9
ENSG00000301898	02-Medium	0.51	11.94	G2	C1	—	—	—	0	0
ENSG00000298801	02-Medium	0.51	14.28	G1	C2	—	—	—	104	221
ENSG00000293897	02-Medium	0.51	17.87	G1	C2	—	—	—	122	272
CFB	02-Medium	0.51	9.30	G1	C2	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2), MAC.LAM.lipid_opsonization (L2), MAC.alveolar.scavenging_endocytic (L2), MAC.resident_repair.ECM_stromal_crosstalk (L2)	PC.IgG_systemic.interacting (Tier: relevant)	94 cells — complete matches	508	1,239
NELFE	02-Medium	0.51	13.45	G1	C2	—	—	—	66	84
AGER	02-Medium	0.51	9.30	G1	C2	EPI.alveolar_type_1 (L1S), EPI.alveolar_type_1.baseline (L2)	T.CD4_Treg (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	39 cells — complete matches	164	276
DDAH2	02-Medium	0.51	9.30	G1	C2	EPI.salivary_intercalated_defense.inflammatory (L2)	—	5 cells — complete matches	146	231
ZSCAN16-AS1	02-Medium	0.51	11.15	G2	C1	—	B.naive.baseline (Tier: relevant)	B.naive.baseline (L2)	19	48
ENSG00000299124	02-Medium	0.51	12.65	G2	C1	—	—	—	23	59
IGF2-AS	02-Medium	0.51	8.95	G1	C2	—	—	EC.arterial.angiogenic_tip (L2), EC.arterial.inflammatory (L2), EC.arterial.mito_contact (L2)	40	125
ENSG00000307923	02-Medium	0.50	14.50	G1	C2	—	—	—	371	796
MDC1	02-Medium	0.50	6.06	G1	C2	—	T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant)	10 cells — complete matches	155	295
ZSCAN16	02-Medium	0.50	12.22	G2	C2	—	T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	22 cells — complete matches	19	48
HCG15	02-Medium	0.50	11.27	G1	C2	—	—	EC.capillary.stress (L2), EPI.ileal_enterocyte_crypt.proliferative_G2M (L2), FIB.adventitial.inflammatory_activated (L2)	25	57
CSNK2B	02-Medium	0.50	9.30	G1	C2	—	—	—	54	128
ENSG00000263020	02-Medium	0.50	9.30	G1	C2	—	—	—	54	128
ENSG00000272501	02-Medium	0.50	19.41	G1	C2	—	—	—	151	319
ENSG00000301971	02-Medium	0.50	14.87	G1	C2	—	—	—	195	362
ENSG00000291111	02-Medium	0.50	13.09	G1	C2	—	—	—	212	386
TCF19	02-Medium	0.50	13.73	G1	C2	EPI.esophageal_suprabasal.proliferative_S (L2), HEP.acute_phase.proliferative (L2)	B.naive.restrained (Tier: specific) T.CD4_transitional (Tier: relevant) B.naive.proteostasis (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	46 cells — complete matches	196	428
HLA-G	02-Medium	0.50	10.07	G1	C2	—	T.CD4_transitional (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	33 cells — complete matches	74	109
ENSG00000310474	02-Medium	0.50	7.73	G1	C2	—	—	—	16	19
TH	02-Medium	0.49	15.96	G1	C2	NEU.INH_PVALB.serotonergic (L2)	PC.IgG_systemic.interacting (Tier: relevant)	13 cells — complete matches	35	118
ENSG00000298457	02-Medium	0.49	18.60	G1	C2	—	—	—	51	155
TNF	02-Medium	0.49	9.30	G2	C1	B.naive.activated (L2), EC.capillary.inflammatory (L2), EPI.ectocervical_granular.inflammatory (L2), EPI.renal_principal_cell.inflammatory (L2), ILC2.activated (L2), MAC.alveolar.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2), T.CD4_Trm.activated (L2), T.CD4_cytotoxic.NK_adapted (L2), T.CD8_Trm.inflammatory (L2)	B_cell (Tier: specific) T_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Trm (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.remodeling (Tier: relevant) NK.cytokine_tissue_activation (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	111 cells — complete matches	75	194
ATP6V1G2	02-Medium	0.49	9.70	G1	C2	—	T.CD4_Treg (Tier: specific) B.naive.purinergic (Tier: specific)	12 cells — complete matches	73	194
NFKBIL1	02-Medium	0.49	10.56	G1	C2	—	—	4 cells — complete matches	101	243
APOM	02-Medium	0.49	9.30	G1	C2	EPI.ileal_bile_transport.absorptive_xenobiotic (L2)	T.CD4_Trm.metal_stress (Tier: relevant)	13 cells — complete matches	14	16
DDX39B	02-Medium	0.49	11.26	G1	C2	—	—	—	112	383
ITPR3	02-Medium	0.49	8.39	G2	C1	—	B.naive.restrained (Tier: specific) B.naive.proteostasis (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	34 cells — complete matches	9	32
HLA-DPB2	02-Medium	0.49	12.09	G1	C2	—	—	—	211	384
ENSG00000227766	02-Medium	0.49	4.44	G1	C2	—	—	—	167	362
PRRC2A	02-Medium	0.49	9.30	G2	C1	—	—	—	110	204
ENSG00000244255	02-Medium	0.49	9.30	G1	C2	—	—	—	32	43
DDR1	02-Medium	0.49	16.52	G2	C2	—	T.CD8_Tem.signaling_turnover (Tier: relevant)	10 cells — complete matches	121	263
POLR1HASP.2	02-Medium	0.49	10.08	G1	C2	—	—	—	341	670
WDR46	02-Medium	0.49	4.87	G1	C2	—	B.age_associated.migratory (Tier: relevant)	4 cells — complete matches	15	28
SLC44A4	02-Medium	0.48	9.30	G1	C2	EPI.hepatic_ductular_cholangiocyte.ion_transport (L2), EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (L2), EPI.pancreatic_ductal_bicarbonate.barrier_mucin (L2)	EPI.colonocyte (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant)	46 cells — complete matches	23	31
HLA-DPA3	02-Medium	0.48	14.49	G1	C2	—	—	—	217	398
TUBB	02-Medium	0.48	5.62	G1	C2	CHOND.activated_fibro_like (L2), DC.cDC1.proliferative (L2), DC.cDC2.proliferative (L2), EPI.colonic_enteroendocrine.progenitor (L2), EPI.ileal_goblet.immature (L2), OLG.reactive_repair (L2), THYMO.proliferative_S (L2)	B.naive.antigen_presenting_ready (Tier: relevant)	8 cells — complete matches	165	310
BTN2A2	02-Medium	0.48	7.45	G2	C1	—	B.memory (Tier: specific) B.naive.activated (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated.migratory (Tier: relevant) B.naive.baseline (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant)	21 cells — complete matches	21	42
ZSCAN31	02-Medium	0.48	13.73	G1	C2	—	T.CD8_Tem.signaling_turnover (Tier: relevant)	19 cells — complete matches	28	78
ENSG00000290891	02-Medium	0.48	9.83	G2	C2	—	—	—	19	48
HLA-DRB9	02-Medium	0.48	13.84	G1	C2	—	—	—	337	743
ENSG00000296082	02-Medium	0.48	19.53	G1	C2	—	—	—	136	282
ENSG00000288473	02-Medium	0.48	15.15	G2	C2	—	—	—	61	160
INS	02-Medium	0.48	9.30	G1	C2	—	—	—	36	121
INS-IGF2	02-Medium	0.48	9.30	G1	C2	EPI.pancreatic_ductal_progenitor.ADM_like (L2)	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction (Tier: relevant) EPI.pancreatic_islet.delta (Tier: relevant)	29 cells — complete matches	36	121
IGF2	02-Medium	0.48	11.19	G1	C2	EC.venous.remodeling_stalk (L2), IPSC.mesendo_primed (L2), SMC.metabolic (L2)	—	58 cells — complete matches	43	132
DHFRP2	02-Medium	0.48	20.18	G2	C2	—	—	—	16	20
DDX39B-AS1	02-Medium	0.47	9.30	G2	C2	—	B.naive (Tier: specific) B.naive.metabolic (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	12 cells — complete matches	56	182
ENSG00000299760	02-Medium	0.47	9.30	G2	C2	—	—	—	56	182
MIR6834	02-Medium	0.47	5.79	G1	C2	—	—	—	10	10
PFDN6	02-Medium	0.47	5.79	G1	C2	—	—	EPI.colonic_tuft.homeostatic (L2)	10	10
H1-2	02-Medium	0.47	4.08	G2	C1	—	—	—	6	29
GPANK1	02-Medium	0.47	9.30	G1	C2	—	B.naive.baseline (Tier: relevant)	6 cells — complete matches	27	43
HMGN4	02-Medium	0.47	8.15	G2	C1	—	—	—	7	9
HCG9	02-Medium	0.47	9.06	G1	C2	—	PC.IgG_systemic.interacting (Tier: relevant)	10 cells — complete matches	46	80
ENSG00000293479	02-Medium	0.47	14.59	G2	C2	—	—	—	1	15
LY6G6E	02-Medium	0.47	14.59	G2	C2	—	—	—	1	15
HCG14	02-Medium	0.47	12.79	G2	C1	—	T.CD8_Tcm (Tier: specific) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	16 cells — complete matches	23	59
ENSG00000294261	02-Medium	0.47	13.15	G1	C2	—	—	—	227	409
HLA-DRB5	02-Medium	0.47	15.69	G1	C2	EC.venous.baseline (L2), EPI.endocervical_secretory.secretory_translocon (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MG.phagocytic_APC (L2), NK.adaptive_classII_inhibitory (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	193 cells — complete matches	364	756
WFS1	02-Medium	0.47	8.94	G1	C2	EC.lymphatic.baseline (L2)	B.naive.remodeling (Tier: relevant)	19 cells — complete matches	3	20
H2BC4	02-Medium	0.46	2.67	G2	C1	—	—	—	2	1
ENSG00000297040	02-Medium	0.46	20.38	G1	C2	—	—	—	180	389
ENSG00000290051	02-Medium	0.46	13.33	G2	C2	—	—	—	0	0
RNF5	02-Medium	0.46	9.30	G2	C2	—	—	SKM.type_1_slow (L1S), EPI.salivary_serous_acinar.secretory_active (L2), SKM.type_1_slow.oxidative (L2)	128	173
LINC01556	02-Medium	0.46	11.21	G1	C2	—	B.naive.antigen_presenting_ready (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	20 cells — complete matches	36	115
ENSG00000301948	02-Medium	0.46	12.13	G1	C2	—	—	—	217	398
POLR1H	02-Medium	0.46	9.60	G2	C2	—	—	—	134	224
COL11A2	02-Medium	0.46	12.45	G2	C2	—	B.naive.purinergic (Tier: specific) PC.IgG_systemic.interacting (Tier: relevant)	17 cells — complete matches	205	381
MSH5	02-Medium	0.46	9.30	G2	C2	—	T.CD4_Tcm.Tfh_like (Tier: specific) B.naive.baseline (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant)	13 cells — complete matches	7	14
MSH5-SAPCD1	02-Medium	0.46	9.30	G2	C2	—	B.naive.purinergic (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD8_Tcm.NK_like (Tier: relevant)	15 cells — complete matches	7	13
C6orf47	02-Medium	0.46	13.40	G2	C2	—	B.age_associated.activated (Tier: relevant) B.naive.proteostasis (Tier: relevant)	11 cells — complete matches	86	156
CDSN	02-Medium	0.46	18.37	G2	C2	—	—	EPI.skin_sweat_duct_keratinocyte.barrier (L2)	1	2
ZKSCAN4	02-Medium	0.45	12.72	G2	C2	—	B.memory.migratory (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant)	21 cells — complete matches	0	0
ENSG00000293281	02-Medium	0.45	17.82	G2	C2	—	—	—	16	20
ENSG00000229836	02-Medium	0.45	4.93	G1	C2	—	—	—	5	4
LINC02570	02-Medium	0.45	18.79	G1	C2	—	—	—	29	61
ENSG00000286176	02-Medium	0.45	9.15	G1	C2	—	—	—	3	20
ATP6V1G2-DDX39B	02-Medium	0.45	13.42	G2	C2	—	T.CD4_Treg (Tier: specific) B.naive.purinergic (Tier: specific)	11 cells — complete matches	69	185
ENSG00000310084	02-Medium	0.45	10.90	G1	C2	—	—	—	337	743
STK19	02-Medium	0.45	13.25	G2	C2	—	B.age_associated.migratory (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	12 cells — complete matches	35	52
SLC17A3	02-Medium	0.45	4.39	G1	C2	—	B.naive.purinergic (Tier: specific) EPI.renal_proximal_tubule.detox_antioxidant (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	13 cells — complete matches	156	373
PPT2	02-Medium	0.45	9.30	G1	C2	—	T.CD4_transitional (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	14 cells — complete matches	52	132
PPT2-EGFL8	02-Medium	0.45	9.30	G1	C2	—	T.CD4_transitional (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	14 cells — complete matches	52	132
EHMT2	02-Medium	0.45	11.16	G1	C2	—	ILC2.quiescent (Tier: relevant)	5 cells — complete matches	47	89
BTN2A3P	02-Medium	0.44	8.32	G1	C2	—	—	—	38	74
BTN2A3P.2	02-Medium	0.44	8.32	G1	C2	—	—	—	38	74
ENSG00000296349	02-Medium	0.44	6.50	G2	C1	—	—	—	2	12
LST1	02-Medium	0.44	14.24	G1	C2	granulocyte (L1), macrophage (L1), monocyte (L1), MAC.MDM (L1S), MONO.CD16 (L1S), ILC2.activated (L2), MAC.MDM.inflammatory_phagocytic (L2), MONO.CD14.baseline (L2)	T_cell (Tier: specific) ILC2.quiescent (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	106 cells — complete matches	183	440
ENSG00000308190	02-Medium	0.44	6.24	G2	C2	—	—	—	62	152
H3C1	02-Medium	0.44	4.54	G2	C1	—	—	—	9	17
H4C1	02-Medium	0.44	4.54	G2	C1	—	—	—	9	17
ENSG00000284954	02-Medium	0.44	9.30	G1	C2	—	—	—	49	123
ENSG00000285085	02-Medium	0.44	9.30	G1	C2	—	—	—	49	123
PRRT1	02-Medium	0.44	9.30	G1	C2	—	—	26 cells — complete matches	51	133
SNORD84	02-Medium	0.44	9.30	G2	C2	—	—	—	59	180
CDC123	02-Medium	0.44	5.75	G1	C2	—	—	T.CD4_cytotoxic.precursor (L2)	2	4
H4C4	02-Medium	0.44	1.27	G2	C1	—	—	—	10	31
GNL1	02-Medium	0.44	5.82	G2	C2	—	—	—	74	175
GPSM3	02-Medium	0.44	9.30	G1	C2	—	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_transitional (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant)	50 cells — complete matches	358	590
LINC02571	02-Medium	0.44	19.02	G2	C2	—	—	—	0	1
LTB	02-Medium	0.44	12.88	G1	C2	T.CD4_Tcm (L1S), T.CD4_Tem (L1S), T.CD4_transitional (L1S), T.CD8_Tcm (L1S), T.CD8_transitional (L1S), B.germinal_center.LZ_survival (L2), DC.mig.baseline (L2), HPC.CLP_B_primed (L2), ILC2.activated (L2), T.CD4_Trm.helper_like (L2), T.CD4_cytotoxic.precursor (L2), T.CD8_naive.baseline (L2), T.gamma_delta.central_memory (L2), THYMO.SP_CD8_naive (L2)	B_cell (Tier: specific) T_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Treg (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_transitional (Tier: specific) T.CD8_Trm (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) B.age_associated (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) B.age_associated.activated (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	165 cells — complete matches	127	281
BTN3A1	02-Medium	0.44	7.61	G2	C1	—	B.age_associated.activated (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	20 cells — complete matches	35	65
HLA-DMB	02-Medium	0.44	14.20	G1	C2	EPI.thymic_medullary.proliferative_APC (L2)	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) T.CD8_transitional (Tier: specific) B.naive.activated (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant) B.age_associated.migratory (Tier: relevant) B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.proteostasis (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant)	93 cells — complete matches	224	330
ENSG00000291008	02-Medium	0.44	9.94	G2	C2	—	—	—	19	48
MCCD1	02-Medium	0.43	10.61	G1	C2	—	—	—	35	113
TRIM15	02-Medium	0.43	11.09	G1	C2	—	EPI.pancreatic_ductal_mucinous (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific)	15 cells — complete matches	127	228
ENSG00000290574	02-Medium	0.43	9.94	G1	C2	—	—	—	55	94
HLA-J	02-Medium	0.43	9.94	G1	C2	—	—	—	54	90
TNXB	02-Medium	0.43	9.48	G1	C2	GRANU.neutrophil.antiviral_endotoxin (L2)	T.CD8_Tcm.helper_like (Tier: relevant)	27 cells — complete matches	153	526
HLA-V.2	02-Medium	0.43	7.75	G1	C2	—	—	—	18	22
SNHG32	02-Medium	0.43	13.30	G2	C2	—	—	—	38	69
ENSG00000284607	02-Medium	0.43	7.96	G2	C1	—	—	—	7	9
HSD17B8	02-Medium	0.43	9.17	G2	C2	—	T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	6 cells — complete matches	3	8
TRIM31-AS1	02-Medium	0.43	13.49	G2	C2	—	—	6 cells — complete matches	56	83
ENSG00000291336	02-Medium	0.43	10.90	G2	C1	—	—	—	7	8
PRSS16	02-Medium	0.43	7.23	G1	C2	EPI.thymic_cortical (L1S)	B.memory.migratory (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	21 cells — complete matches	29	45
HSPA1A	02-Medium	0.43	9.30	G2	C2	ASTRO.stress_acute (L2), B.memory.activated (L2), B.naive.activated (L2), DC.cDC2.tolerogenic_regulatory (L2), EC.liver_sinusoidal.stress (L2), EC.lymphatic.activated (L2), EPI.colonocyte.crypt_progenitor (L2), EPI.pancreatic_acinar.stress (L2), EPI.pancreatic_ductal_bicarbonate.stress (L2), EPI.renal_distal_tubule.stress (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), EPI.tracheal_basal.activated_stress (L2), FIB.skin_sheath.stress_chaperone (L2), HEP.canalicular_transport.inflammatory (L2), IPSC.stress (L2), MAC.kupffer.stress (L2), NK.cytokine_lung_immediate_early (L2), OLG.stress (L2), SMC.activated (L2), T.CD4_Trm.metal_stress (L2), T.CD8_transitional.stress (L2), T.MAIT.stress (L2), THYMO.DP_early_stress (L2), THYMO.SP_CD8_naive_stress (L2)	EPI.colonocyte (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Trm (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	104 cells — complete matches	81	205
HLA-V	02-Medium	0.43	7.30	G1	C2	—	—	—	8	13
PPP1R11	02-Medium	0.43	7.83	G2	C2	—	—	—	45	70
ENSG00000310496	02-Medium	0.42	8.95	G1	C2	—	—	—	112	169
HLA-K	02-Medium	0.42	8.95	G1	C2	—	—	—	112	169
ZKSCAN8P1	02-Medium	0.42	11.10	G2	C2	—	—	—	26	99
ENSG00000273333	02-Medium	0.42	9.30	G1	C2	—	—	—	245	490
HLA-A	02-Medium	0.42	7.63	G2	C2	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.renal_principal_cell.injury_repair (L2), EPI.skin_appendage_keratinocyte.ductal_immune_interacting (L2), FIB.skin_sheath.ECM_immune (L2), HEP.pericentral_lipoprotein.ApoB_coagulation (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	T.CD4_Treg (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	78 cells — complete matches	281	510
HCG4	02-Medium	0.42	7.50	G1	C2	—	—	—	13	17
H2BC7	02-Medium	0.42	0.71	G2	C1	—	—	—	3	3
ENSG00000276302	02-Medium	0.42	13.55	G2	C2	—	—	—	0	0
ZSCAN26	02-Medium	0.42	13.55	G2	C2	—	T.CD8_Tem (Tier: specific) B.naive.antigen_presenting_ready (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	10 cells — complete matches	0	0
H2BC5	02-Medium	0.42	2.50	G2	C2	—	—	—	1	1
MIR6832	02-Medium	0.42	9.30	G1	C2	—	—	—	99	170
ENSG00000306705	02-Medium	0.42	12.07	G2	C2	—	—	—	2	7
CAMK1D	02-Medium	0.42	3.86	G1	C2	—	B_cell (Tier: specific) B.memory (Tier: specific) B.naive (Tier: specific) B.naive.purinergic (Tier: specific) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.proteostasis (Tier: relevant)	14 cells — complete matches	2	4
ENSG00000204422	02-Medium	0.42	9.30	G2	C2	—	—	—	1	15
HLA-H	02-Medium	0.42	9.02	G1	C2	—	—	—	204	363
HLA-H.2	02-Medium	0.42	9.02	G1	C2	—	—	—	204	363
ATF6B	02-Medium	0.42	9.30	G1	C2	—	—	B.age_associated.naive_transitional (L2), EC.lymphatic.valve (L2)	71	164
H4C3	02-Medium	0.42	3.43	G2	C1	—	—	—	2	1
PRR3	02-Medium	0.42	5.96	G2	C2	—	B.naive.metabolic (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	8 cells — complete matches	8	9
PPP1R18	02-Medium	0.42	6.06	G2	C1	—	T.CD4_transitional (Tier: relevant) B.age_associated.migratory (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant)	12 cells — complete matches	153	285
ZSCAN9	02-Medium	0.42	14.54	G2	C2	—	B.naive.activated (Tier: specific) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant)	12 cells — complete matches	17	36
ENSG00000284829	02-Medium	0.41	12.50	G2	C2	—	—	—	41	114
ENSG00000286974	02-Medium	0.41	11.68	G1	C2	—	—	—	95	225
ZKSCAN3	02-Medium	0.41	12.82	G2	C2	—	B.naive.restrained (Tier: specific) PC.IgG_systemic.interacting (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	19 cells — complete matches	14	33
PSORS1C2	02-Medium	0.41	19.64	G2	C2	—	—	5 cells — complete matches	44	83
ENSG00000290474	02-Medium	0.41	10.09	G2	C1	—	—	—	18	16
HLA-DRB6.2	02-Medium	0.41	13.59	G2	C2	—	—	—	332	742
ENSG00000290047	02-Medium	0.41	5.79	G1	C2	—	—	—	8	9
PPP2R2C	02-Medium	0.41	5.63	G1	C2	—	—	EPI.pancreatic_islet (L1S)	3	20
TRIM40	02-Medium	0.41	10.90	G1	C2	—	T.CD8_Trm (Tier: specific) T.CD4_Tcm.effector_like (Tier: relevant)	15 cells — complete matches	60	82
ENSG00000287252	02-Medium	0.41	11.02	G2	C2	—	—	—	9	23
ENSG00000248993	02-Medium	0.40	13.80	G1	C2	—	—	—	188	275
ENSG00000230521	02-Medium	0.40	8.65	G1	C2	—	—	—	19	28
ENSG00000300257	02-Medium	0.40	14.15	G2	C2	—	—	—	9	21
ENSG00000310508	02-Medium	0.40	7.50	G1	C2	—	—	—	14	19
BTNL2	02-Medium	0.40	13.45	G2	C2	—	—	—	105	346
C6orf15	02-Medium	0.40	13.50	G2	C2	—	—	—	1	1
HSPA1L	02-Medium	0.40	9.30	G2	C2	—	T.CD4_Tcm.Tfh_like (Tier: specific) ILC2.quiescent (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	21 cells — complete matches	0	1
HCG4B	02-Medium	0.40	7.38	G1	C2	—	—	—	11	10
AGPAT1	02-Medium	0.40	9.30	G2	C2	—	B.naive.antigen_presenting_ready (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	6 cells — complete matches	27	58
ZKSCAN8	02-Medium	0.40	12.03	G2	C2	—	B.naive.activated (Tier: specific) B.age_associated.activated (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.remodeling (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant)	25 cells — complete matches	17	47
BTN2A1	02-Medium	0.40	7.93	G2	C1	—	—	10 cells — complete matches	18	29
C4orf50	02-Medium	0.40	8.71	G1	C2	T.CD8_Tem.motility_primed (L2)	T_cell (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD8_Trm (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_transitional (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) NK.cytokine_tissue_activation (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	78 cells — complete matches	3	20
ENSG00000261839	02-Medium	0.40	9.92	G2	C2	—	—	—	19	48
ENSG00000295395	02-Medium	0.40	11.94	G1	C2	—	—	—	32	106
ENSG00000280107	02-Medium	0.40	11.84	G2	C2	—	—	—	16	46
RNF39	02-Medium	0.40	8.44	G2	C2	—	—	41 cells — complete matches	25	47
ENSG00000299128	02-Medium	0.40	4.92	G2	C1	—	—	—	5	7
H2AC5P	02-Medium	0.40	4.92	G2	C1	—	—	—	5	7
H2AC6	02-Medium	0.39	2.38	G2	C2	—	—	—	1	1
BTN3A3	02-Medium	0.39	7.71	G2	C1	—	T.CD8_Tem (Tier: specific) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	16 cells — complete matches	35	71
HCG25	02-Medium	0.39	12.41	G1	C2	—	T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) B.age_associated.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	29 cells — complete matches	178	322
ENSG00000228302	02-Medium	0.39	3.40	G1	C2	—	—	—	2	4
FKBPL	02-Medium	0.39	9.30	G1	C2	—	B.naive.activated (Tier: specific) B.naive.remodeling (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	19 cells — complete matches	46	125
ENSG00000310558	02-Medium	0.39	9.30	G2	C2	—	—	—	0	0
SLC17A2	02-Medium	0.39	3.68	G1	C2	—	—	8 cells — complete matches	96	265
ENSG00000289375	02-Medium	0.39	9.30	G2	C2	—	—	—	0	0
PGBD1	02-Medium	0.39	12.74	G2	C2	—	EPI.colonic_enteroendocrine.progenitor (Tier: relevant) ILC2.quiescent (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant)	22 cells — complete matches	12	33
SNORD52	02-Medium	0.39	9.30	G2	C2	—	—	—	32	55
TRIM10	02-Medium	0.39	6.87	G1	C2	—	—	—	122	254
ENSG00000290803	02-Medium	0.38	6.49	G1	C2	—	—	—	3	20
LY6G6C	02-Medium	0.38	9.30	G2	C2	EPI.skin_sweat_duct_keratinocyte.barrier (L2)	T.CD4_Tcm.retro_ZNF117 (Tier: relevant)	7 cells — complete matches	1	15
NEU1	02-Medium	0.38	12.08	G2	C2	—	T.CD4_Trm (Tier: specific) T.CD4_Trm.metal_stress (Tier: relevant)	7 cells — complete matches	26	37
GUSBP2	02-Medium	0.38	6.95	G2	C1	—	—	—	2	3
JAKMIP1	02-Medium	0.38	6.78	G1	C2	T.CD8_Tem.motility_primed (L2)	T_cell (Tier: specific) T.CD4_Treg (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) T.CD8_Trm (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) T.CD4_transitional (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) NK.cytokine_tissue_activation (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tcm.NK_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	77 cells — complete matches	3	20
ENSG00000272217	02-Medium	0.38	11.03	G1	C2	—	—	—	178	320
ENSG00000287050	02-Medium	0.38	7.37	G2	C1	—	—	—	1	3
SLC17A1	02-Medium	0.38	4.12	G1	C2	—	EPI.renal_proximal_tubule.detox_antioxidant (Tier: relevant)	4 cells — complete matches	29	75
ABT1	02-Medium	0.38	7.46	G2	C1	—	—	T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.tissue_effector (L2)	10	20
IER3-AS1	02-Medium	0.38	9.86	G1	C2	—	—	—	155	290
ENSG00000289395	02-Medium	0.38	2.73	G1	C2	—	—	—	2	4
ENSG00000304640	02-Medium	0.38	2.73	G1	C2	—	—	—	2	4
ENSG00000288751	02-Medium	0.37	10.40	G1	C2	—	—	—	10	15
LY6G6D	02-Medium	0.37	9.30	G1	C2	—	—	—	9	22
HCG11	02-Medium	0.37	7.70	G2	C1	—	T.CD4_Tcm.Tfh_like (Tier: specific) B.age_associated.migratory (Tier: relevant)	16 cells — complete matches	9	13
MPIG6B	02-Medium	0.37	9.30	G1	C2	MONO.CD14.platelet_bound (L2), MONO.CD16.platelet_bound (L2)	B.memory (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	27 cells — complete matches	1	15
BTN1A1	02-Medium	0.37	8.45	G2	C2	—	—	FIB.barrier_purinergic (L1S), FIB.barrier_purinergic.lipid_secretory (L2)	2	3
DDR1-DT	02-Medium	0.37	12.49	G2	C2	—	—	—	38	97
ENSG00000310484	02-Medium	0.37	11.15	G2	C2	—	—	—	5	7
ENSG00000240801	02-Medium	0.36	4.78	G1	C2	—	—	—	38	124
LY6G6F	02-Medium	0.36	9.30	G1	C2	—	—	—	1	15
LY6G6F-LY6G6D	02-Medium	0.36	9.30	G1	C2	—	—	—	1	15
ENSG00000306378	02-Medium	0.36	9.30	G2	C2	—	—	—	76	375
ENSG00000286652	02-Medium	0.36	3.92	G2	C1	—	—	—	13	36
ENSG00000306895	02-Medium	0.36	8.95	G1	C2	—	—	—	2	7
MIR219A1	02-Medium	0.36	8.95	G1	C2	—	—	—	2	7
RING1	02-Medium	0.36	8.95	G1	C2	—	T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	T.CD4_Tcm.imprinted_splicing (L2), T.CD8_Trm.muscosal_Tc17 (L2)	2	7
ENSG00000299674	02-Medium	0.36	6.05	G2	C2	—	—	—	0	0
RXRB	02-Medium	0.36	13.57	G2	C2	—	—	8 cells — complete matches	11	29
ENSG00000293518	02-Medium	0.35	6.06	G2	C2	—	—	—	1	11
MICE	02-Medium	0.35	9.64	G2	C2	—	—	—	91	188
EHMT2-AS1	02-Medium	0.35	14.72	G2	C2	—	EPI.colonocyte (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	16 cells — complete matches	4	5
ZNF322	02-Medium	0.35	6.38	G2	C2	—	—	4 cells — complete matches	2	0
ENSG00000300236	02-Medium	0.35	8.01	G2	C2	—	—	—	7	9
TNNI2	02-Medium	0.34	4.62	G1	C2	SKM.type_1_slow.glycolytic (L2)	B.naive (Tier: specific) B.naive.activated (Tier: specific) B.naive.restrained (Tier: specific) B.age_associated.migratory (Tier: relevant) B.naive.baseline (Tier: relevant) B.naive.metabolic (Tier: relevant) B.naive.remodeling (Tier: relevant)	81 cells — complete matches	29	80
LSP1	02-Medium	0.34	4.16	G1	C2	B.age_associated.migratory (L2), EPI.salivary_myoepithelial.junctional_transport (L2), EPI.skin_follicular_keratinizing.upper_infundibulum (L2), EPI.thymic_medullary.canonical_alarmin (L2), T.CD4_Treg.APC_interactive (L2), T.CD8_Trm.cytotoxic (L2)	T_cell (Tier: specific) B.memory (Tier: specific) T.CD8_Tem (Tier: specific) B.naive.activated (Tier: specific) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	102 cells — complete matches	41	132
NOA1	02-Medium	0.34	3.62	G1	C2	—	T.CD4_transitional.primed_helper_effector (Tier: relevant)	7 cells — complete matches	21	48
TMPOP1	02-Medium	0.34	4.39	G2	C2	—	—	—	0	0
POLR2B	02-Medium	0.33	3.39	G1	C2	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling (L2)	B.naive.baseline (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant)	4 cells — complete matches	21	50
CLIC1	02-Medium	0.33	9.30	G2	C2	PC.IgG_systemic.secretory (L2)	—	10 cells — complete matches	159	256
FAM99A	02-Medium	0.33	4.19	G1	C2	—	—	—	35	115
MIR7847	02-Medium	0.33	4.45	G1	C2	—	—	—	23	75
ENSG00000290870	02-Medium	0.33	10.04	G2	C2	—	—	—	4	4
ENSG00000275846	02-Medium	0.33	5.23	G2	C1	—	—	—	3	2
ENSG00000285761	02-Medium	0.33	8.64	G2	C2	—	—	—	123	218
ENSG00000272236	02-Medium	0.32	9.24	G2	C2	—	—	—	38	69
ENSG00000300261	02-Medium	0.32	5.14	G2	C1	—	—	—	4	7
ENSG00000295483	02-Medium	0.32	4.57	G2	C2	—	—	—	0	0
ENSG00000308216	02-Medium	0.32	5.63	G2	C1	—	—	—	6	6
PPP1R10	02-Medium	0.32	5.65	G2	C2	HPC.MPP_activated (L2), MEL.dedifferentiated_migratory (L2)	PC.IgG_systemic.metabolic (Tier: relevant)	4 cells — complete matches	68	161
LY6G5B	02-Medium	0.32	9.30	G2	C2	—	T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	26 cells — complete matches	11	17
H2AC3P	02-Medium	0.32	4.20	G1	C2	—	—	—	60	156
ENSG00000294330	02-Medium	0.32	5.38	G2	C2	—	—	—	10	23
DHX16	02-Medium	0.32	6.42	G1	C2	—	T.CD4_cytotoxic.NK_adapted (Tier: relevant)	5 cells — complete matches	164	300
LINC02708	02-Medium	0.32	4.31	G1	C2	—	—	—	24	88
ENSG00000285571	02-Medium	0.31	5.26	G2	C1	—	—	—	4	2
ZNF311	02-Medium	0.31	11.68	G2	C2	—	EPI.colonocyte.crypt_progenitor (Tier: relevant)	8 cells — complete matches	25	61
COX11P1	02-Medium	0.31	3.11	G2	C2	—	—	—	0	0
ENSG00000303124	02-Medium	0.31	4.37	G2	C2	—	—	—	39	94
LINC02569	02-Medium	0.31	4.35	G2	C2	—	—	—	41	82
PHF1	02-Medium	0.31	5.21	G2	C2	—	—	MONO.CD14.inflammatory (L2), PLAT.megakaryocytic (L2)	0	0
ENSG00000231487	02-Medium	0.31	2.94	G1	C2	—	—	—	20	62
ZBTB12	02-Medium	0.31	13.13	G2	C2	—	B.age_associated.migratory (Tier: relevant) B.naive.remodeling (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant)	12 cells — complete matches	24	33
LY6G5C	02-Medium	0.31	13.27	G2	C2	—	T.CD8_Tcm (Tier: specific) ILC2.quiescent (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	30 cells — complete matches	38	57
DXO	02-Medium	0.31	13.25	G2	C2	—	B.age_associated.activated (Tier: relevant)	B.age_associated.activated (L2), T.CD4_Treg.Tr1_like (L2)	46	63
HLA-F	02-Medium	0.30	9.31	G2	C2	EPI.skin_appendage_keratinocyte.ductal_immune_interacting (L2)	—	11 cells — complete matches	205	352
FAM99B	02-Medium	0.30	3.00	G1	C2	—	—	—	29	101
TNNT3	02-Medium	0.30	3.45	G1	C2	SKM.type_2_fast (L1S), SKM.type_1_slow.glycolytic (L2)	—	52 cells — complete matches	24	72
ATAT1	02-Medium	0.30	5.97	G1	C2	—	T.CD8_Tem (Tier: specific) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	16 cells — complete matches	138	274
ENSG00000299209	02-Medium	0.30	4.03	G1	C2	—	—	—	14	42
IGFBP7	02-Medium	0.30	3.08	G1	C2	ASPC.niche_keeping_progenitor (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), EPI.skin_hair_follicle_bulge.niche_crosstalk (L2), EPI.skin_sebaceous_duct_luminal.ECM_remodelling (L2), FIB.barrier_secretory.homeostasis (L2), FIB.neurolectin_mucosa.remodeling_repair (L2), FIB.reticular.stromal_niche (L2), MAC.alveolar.capillary_interacting (L2), MUSC.activated_migratory (L2), NK.cytokine_biosynthetic_primed (L2), NK.cytokine_repair_primed (L2), NK.cytokine_vascular_patrolling (L2)	natural_killer_cell (Tier: specific) NK.natural_killer_cell (Tier: specific) ILC2.quiescent (Tier: relevant) NK.adaptive_biosynthetic_primed (Tier: relevant) NK.cytokine_quiescent (Tier: relevant) NK.cytokine_tissue_activation (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant)	177 cells — complete matches	21	47
NRM	02-Medium	0.29	5.24	G1	C2	—	B.memory.migratory (Tier: relevant) B.naive.antigen_presenting_ready (Tier: relevant) B.naive.proteostasis (Tier: relevant)	17 cells — complete matches	153	292
ENSG00000225173	02-Medium	0.29	11.27	G2	C2	—	—	—	23	59
ENSG00000289282	02-Medium	0.29	9.30	G2	C2	—	—	—	0	0
ITPR3-AS1	02-Medium	0.29	7.94	G2	C2	—	—	—	2	12
HLA-E	02-Medium	0.29	4.83	G2	C2	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.thymic_cortical.baseline (L2), EPI.thymic_medullary.stress_APC (L2), FIB.interstitial.immune_interact (L2), THYMO.SP_CD4_naive (L2)	T_cell (Tier: specific)	37 cells — complete matches	193	384
ENSG00000288805	02-Medium	0.28	9.25	G2	C2	—	—	—	32	64
HCG4P8	02-Medium	0.28	8.55	G2	C2	—	—	—	3	2
SLC17A4	02-Medium	0.28	4.00	G2	C2	—	—	18 cells — complete matches	36	87
LINC00336	02-Medium	0.28	8.23	G2	C2	—	—	5 cells — complete matches	2	12
ENSG00000305894	02-Medium	0.28	12.83	G2	C2	—	—	—	22	54
ENSG00000297504	02-Medium	0.27	4.73	G2	C2	—	—	—	11	26
ENSG00000297763	02-Medium	0.27	12.47	G2	C2	—	—	—	20	57
ENSG00000301820	02-Medium	0.26	10.50	G2	C2	—	—	—	16	17
MOG	02-Medium	0.26	10.34	G2	C2	oligodendrocyte (L1), OLG.oligodendrocyte (L1S)	—	10 cells — complete matches	6	8
LINC02935	02-Medium	0.24	13.76	G2	C2	—	—	—	4	10
LINC00240	02-Medium	0.23	7.38	G2	C2	—	B.age_associated (Tier: relevant) B.age_associated.activated (Tier: relevant)	12 cells — complete matches	24	27
ENSG00000296261	02-Medium	0.22	3.69	G2	C2	—	—	—	0	0
ENSG00000288588	02-Medium	0.21	9.59	G2	C2	—	—	—	3	14
LINC02980	02-Medium	0.20	5.04	G2	C2	—	—	—	19	38
SCGN	02-Medium	0.20	2.49	G2	C2	—	EPI.colonic_enteroendocrine.progenitor (Tier: relevant) EPI.pancreatic_islet.delta (Tier: relevant)	24 cells — complete matches	18	36
ENSG00000290217	02-Medium	0.20	2.43	G2	C2	—	—	—	18	36
CARMIL1	02-Medium	0.19	3.44	G2	C2	—	T.CD4_transitional (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_cytotoxic.NK_adapted (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant)	33 cells — complete matches	11	31
NUDT5	02-Medium	0.15	5.43	G2	C2	—	—	—	0	0
PAM	02-Medium	0.14	5.07	G2	C2	—	EPI.colonic_enteroendocrine.progenitor (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant)	16 cells — complete matches	1	2
SEC61A2	02-Medium	0.10	5.53	G2	C2	—	PC.IgG_systemic.interacting (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	26 cells — complete matches	1	0
SPINK2	02-Medium	0.08	5.03	G2	C2	haematopoietic_progenitor_cell (L1), HPC.haematopoietic_progenitor_cell (L1S), EPI.salivary_myoepithelial.baseline (L2)	T.CD8_Tcm (Tier: specific) T.CD8_Trm (Tier: specific) B.naive.activated (Tier: specific) T.CD4_Tcm.Tfh_like (Tier: specific) haematopoietic_progenitor_cell (Tier: relevant) ILC2.quiescent (Tier: relevant) PC.IgG_systemic.interacting (Tier: relevant) PC.IgG_systemic.metabolic (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	92 cells — complete matches	18	43

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.