Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST90004167 · All tissues

IDP dMRI TBSS L2 Uncinate fasciculus R: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: White matter microstructure

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte_precursor_cell	15.00	Significant	5.13e-09	1.35	Specific	461	1,454
2	induced_pluripotent_stem_cell	5.32	Nominal	1.09e-31	1.23	Other	0	0
3	melanocyte	3.95	Nominal	0.21	1.12	Other	97	309
4	endothelial_cell	2.94	Nonsignificant	5.00e-18	1.15	Other	373	974
5	granulosa_cell	2.89	Nonsignificant	0.74	1.06	Other	293	670
6	platelet	2.33	Nonsignificant	—	1.04	Other	85	104
7	pericyte	2.05	Nonsignificant	0.03	1.09	Other	128	517
8	astrocyte	1.91	Nonsignificant	0.15	1.08	Other	256	1,203
9	epithelial_cell	1.69	Nonsignificant	6.30e-36	1.18	Other	24	47
10	smooth_muscle_cell	1.37	Nonsignificant	1.00	1.00	Other	27	139
11	haematopoietic_progenitor_cell	1.27	Nonsignificant	1.00	0.95	Other	262	502
12	fibroblast	1.24	Nonsignificant	1.00	0.97	Other	184	826
13	oligodendrocyte	1.22	Nonsignificant	1.00	0.97	Other	385	1,507
14	monocyte	0.68	Nonsignificant	1.00	0.91	Other	2,176	3,871
15	adipocyte	0.67	Nonsignificant	1.00	0.95	Other	33	111
16	adipose_stem_and_progenitor_cell	0.61	Nonsignificant	1.00	0.88	Other	327	954
17	muscle_stem_cell	0.56	Nonsignificant	1.00	0.86	Other	7	27
18	granulocyte	0.36	Nonsignificant	1.00	0.77	Other	5	6
19	mesothelial_cell	0.23	Nonsignificant	1.00	0.74	Other	6	36
20	thymocyte	0.13	Nonsignificant	1.00	0.89	Other	168	512
21	macrophage	0.12	Nonsignificant	1.00	0.77	Other	813	1,732
22	plasma_cell	0.10	Nonsignificant	1.00	0.72	Other	17	24
23	schwann_cell	0.09	Nonsignificant	1.00	0.75	Other	10	57
24	neuron	0.08	Nonsignificant	1.00	0.83	Other	330	1,328
25	dendritic_cell	0.05	Nonsignificant	1.00	0.74	Other	496	724
26	B_cell	0.03	Nonsignificant	1.00	0.68	Other	356	694
27	natural_killer_cell	0.02	Nonsignificant	1.00	0.74	Other	1,204	2,052
28	T_cell	9.33e-03	Nonsignificant	1.00	0.46	Other	470	959
29	microglia	8.98e-03	Nonsignificant	1.00	0.58	Other	61	129
30	innate_lymphoid_cell_2	8.13e-03	Nonsignificant	1.00	0.60	Other	3	8
31	cardiomyocyte	7.83e-03	Nonsignificant	1.00	0.65	Other	533	2,045
32	skeletal_muscle_cell	3.87e-03	Nonsignificant	1.00	0.53	Other	944	2,600
33	chondrocyte	2.80e-03	Nonsignificant	1.00	0.53	Other	548	1,069
34	hepatocyte	8.67e-04	Nonsignificant	1.00	0.45	Other	1,515	3,822

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar	17.02	Significant	5.23e-17	1.22	Specific	429	1,475
2	OPC.oligodendrocyte_precursor_cell	15.00	Significant	—	—	Specific	413	1,269
3	FIB.transitioning	6.18	Significant	4.16e-07	2.08	Other	172	497
4	EPI.alveolar_type_1	5.62	Significant	1.00	1.18	Relevant	26	101
5	EPI.bile_duct_cholangiocyte	5.32	Nominal	1.00	1.19	Other	37	60
6	IPSC.induced_pluripotent_stem_cell	5.32	Nominal	—	—	Other	0	0
7	MEL.melanocyte	3.95	Nominal	—	—	Other	79	242
8	EC.capillary	3.85	Nominal	1.18e-04	1.43	Other	514	1,635
9	EPI.pancreatic_ductal_mucinous	3.51	Nominal	1.00	1.14	Other	219	430
10	EC.liver_sinusoidal	3.28	Nominal	0.15	1.33	Other	1,083	1,925
11	EC.arterial	3.17	Nominal	0.74	1.01	Other	356	885
12	GRNLSA.granulosa_cell	2.89	Nonsignificant	—	—	Other	257	0
13	EC.heart_remodeling	2.50	Nonsignificant	1.00	0.66	Other	569	1,594
14	FIB.tracheal_subepithelial	2.43	Nonsignificant	—	1.19	Other	0	0
15	PLAT.platelet	2.33	Nonsignificant	—	0.00	Other	38	53
16	EC.venous	2.21	Nonsignificant	0.74	0.97	Other	516	1,387
17	PERI.pericyte	2.05	Nonsignificant	—	—	Other	117	0
18	FIB.reticular	1.91	Nonsignificant	9.60e-03	1.70	Other	19	87
19	ASTRO.astrocyte	1.91	Nonsignificant	—	—	Other	228	1,111
20	EPI.intrahepatic_cholangiocyte_transport	1.58	Nonsignificant	—	1.12	Other	12	42
21	EPI.skin_hair_follicle_companion	1.50	Nonsignificant	—	1.17	Other	8	12
22	EC.lymphatic	1.43	Nonsignificant	0.74	1.00	Other	630	998
23	SMC.smooth_muscle_cell	1.37	Nonsignificant	—	—	Other	20	101
24	EPI.extrahepatic_cholangiocyte	1.33	Nonsignificant	—	0.86	Other	37	71
25	FIB.adventitial	1.32	Nonsignificant	5.09e-03	1.35	Other	268	1,447
26	HPC.haematopoietic_progenitor_cell	1.27	Nonsignificant	—	—	Other	211	370
27	OLG.oligodendrocyte	1.22	Nonsignificant	—	—	Other	384	1,397
28	NEU.INH_LAMP5	1.22	Nonsignificant	0.01	1.20	Other	263	532
29	FIB.interstitial	1.02	Nonsignificant	0.99	0.71	Other	288	940
30	FIB.neurolectin_mucosa	0.99	Nonsignificant	0.99	0.69	Other	133	394
31	EPI.intrahepatic_cholangiocyte_defense	0.82	Nonsignificant	—	0.78	Other	8	13
32	FIB.perivascular_interface	0.78	Nonsignificant	0.99	0.59	Other	0	0
33	MONO.CD14	0.77	Nonsignificant	4.77e-24	1.75	Other	2,294	4,139
34	FIB.lung_alveolar	0.76	Nonsignificant	—	0.00	Other	6	15
35	EPI.skin_sweat_duct_keratinocyte	0.73	Nonsignificant	1.00	0.93	Other	146	301
36	EPI.salivary_duct_excretory	0.71	Nonsignificant	1.00	0.97	Other	85	180
37	EPI.endocervical_secretory	0.69	Nonsignificant	—	0.73	Other	0	0
38	EPI.hepatic_ductular_cholangiocyte	0.69	Nonsignificant	1.00	0.78	Other	83	243
39	ADIPO.adipocyte	0.67	Nonsignificant	—	—	Other	20	62
40	EPI.ileal_enterocyte_absorptive	0.64	Nonsignificant	1.00	0.78	Other	118	338
41	ASPC.adipose_stem_and_progenitor_cell	0.61	Nonsignificant	—	—	Other	324	930
42	MUSC.muscle_stem_cell	0.56	Nonsignificant	—	—	Other	4	18
43	FIB.skin_tenogenic	0.55	Nonsignificant	—	0.00	Other	108	227
44	EPI.gastric_foveolar	0.54	Nonsignificant	—	0.80	Other	0	0
45	FIB.skin_sheath	0.53	Nonsignificant	0.99	0.33	Other	49	118
46	FIB.barrier_secretory	0.52	Nonsignificant	0.99	0.37	Other	81	228
47	GRANU.MAST	0.52	Nonsignificant	9.43e-04	1.90	Other	5	6
48	EPI.ileal_bile_transport	0.50	Nonsignificant	1.00	0.94	Other	61	93
49	FIB.suburothelial	0.47	Nonsignificant	0.99	0.32	Other	122	432
50	FIB.skin_papillary	0.45	Nonsignificant	—	0.00	Other	0	0
51	MAC.resident_iron	0.42	Nonsignificant	3.94e-03	1.31	Other	16	21
52	EPI.salivary_intercalated_defense	0.41	Nonsignificant	1.00	0.76	Other	81	161
53	PC.IgG_systemic	0.41	Nonsignificant	4.57e-06	1.42	Other	41	60
54	EPI.salivary_serous_acinar	0.40	Nonsignificant	1.00	0.80	Other	233	531
55	EPI.renal_proximal_tubule	0.40	Nonsignificant	1.00	0.90	Other	525	806
56	FIB.barrier_purinergic	0.39	Nonsignificant	—	0.00	Other	1	3
57	EPI.pancreatic_islet	0.31	Nonsignificant	1.00	0.86	Other	52	132
58	EPI.skin_keratinocyte_basal	0.30	Nonsignificant	—	0.58	Other	13	26
59	B.age_associated	0.30	Nonsignificant	0.21	1.19	Other	207	350
60	FIB.skin_neurosecretory	0.29	Nonsignificant	—	0.00	Other	0	0
61	EPI.tracheal_basal	0.24	Nonsignificant	1.00	0.71	Other	398	1,120
62	MESO.mesothelial_cell	0.23	Nonsignificant	—	—	Other	2	18
63	EPI.colonic_tuft	0.23	Nonsignificant	—	0.38	Other	7	24
64	MAC.resident_cardiac	0.20	Nonsignificant	7.45e-03	1.19	Other	485	1,074
65	MONO.CD16	0.19	Nonsignificant	1.00	0.52	Other	1,304	1,835
66	EPI.lung_club_secretory	0.19	Nonsignificant	1.00	0.94	Other	5	14
67	EPI.ectocervical_granular	0.18	Nonsignificant	—	0.28	Other	11	23
68	EPI.ileal_goblet	0.18	Nonsignificant	1.00	0.70	Other	181	432
69	EPI.skin_keratinocyte_progenitor	0.17	Nonsignificant	—	0.29	Other	0	3
70	MAC.resident_repair	0.17	Nonsignificant	0.48	1.03	Other	796	1,426
71	EPI.salivary_duct_ion_transport	0.16	Nonsignificant	1.00	0.70	Other	5	11
72	EPI.renal_thick_ascending_limb	0.16	Nonsignificant	1.00	0.67	Other	453	1,153
73	EPI.pancreatic_ductal_bicarbonate	0.16	Nonsignificant	1.00	0.74	Other	131	548
74	EPI.tracheal_suprabasal	0.15	Nonsignificant	1.00	0.71	Other	29	56
75	THYMO.thymocyte	0.13	Nonsignificant	—	—	Other	163	495
76	EPI.esophageal_basal	0.13	Nonsignificant	1.00	0.66	Other	4	10
77	EPI.skin_sebaceous_duct_luminal	0.13	Nonsignificant	1.00	0.61	Other	100	249
78	EPI.ileal_enterocyte_crypt	0.11	Nonsignificant	1.00	0.65	Other	67	113
79	SCHWN.schwann_cell	0.09	Nonsignificant	—	—	Other	7	33
80	EPI.renal_immature_ureteric_bud	0.09	Nonsignificant	1.00	0.81	Other	217	569
81	EPI.alveolar_type_2	0.09	Nonsignificant	1.00	0.59	Other	813	1,853
82	EPI.skin_hair_follicle_bulge	0.08	Nonsignificant	1.00	0.80	Other	51	178
83	GRANU.neutrophil	0.07	Nonsignificant	1.00	0.00	Other	1,235	2,649
84	EPI.tracheal_submucosal_gland	0.06	Nonsignificant	—	0.01	Other	0	0
85	MAC.MDM	0.06	Nonsignificant	4.34e-03	1.24	Other	623	986
86	DC.cDC2	0.06	Nonsignificant	0.07	1.12	Other	1,189	1,793
87	MAC.kupffer	0.06	Nonsignificant	1.00	0.86	Other	189	530
88	PC.IgA_muocsal	0.06	Nonsignificant	1.00	0.43	Other	18	31
89	MAC.LAM	0.05	Nonsignificant	1.10e-05	1.22	Other	914	2,064
90	T.CD4_transitional	0.04	Nonsignificant	0.51	1.11	Other	48	110
91	EPI.skin_keratinocyte_proliferating	0.04	Nonsignificant	1.00	0.73	Other	47	76
92	DC.mig	0.04	Nonsignificant	—	0.93	Other	89	156
93	T.CD8_Tem	0.03	Nonsignificant	5.40e-08	1.15	Other	1,083	1,857
94	DC.cDC1	0.03	Nonsignificant	1.00	0.91	Other	55	112
95	HEP.pericentral_lipoprotein	0.03	Nonsignificant	—	2.35	Other	0	0
96	B.naive	0.02	Nonsignificant	0.34	1.03	Other	307	595
97	EPI.cervical_suprabasal	0.02	Nonsignificant	—	0.00	Other	14	50
98	NEU.INH_VIP	0.02	Nonsignificant	1.00	0.88	Other	241	366
99	NK.natural_killer_cell	0.02	Nonsignificant	—	—	Other	1,204	2,045
100	NEU.INH_PVALB	0.02	Nonsignificant	1.00	0.94	Other	193	183
101	T.CD4_Th2	0.02	Nonsignificant	—	1.32	Other	1	2
102	EPI.renal_principal_cell	0.02	Nonsignificant	1.00	0.51	Other	207	403
103	T.MAIT	0.02	Nonsignificant	0.83	1.04	Other	469	855
104	T.CD4_Th17	0.02	Nonsignificant	0.51	1.11	Other	421	794
105	EPI.skin_follicular_keratinizing	0.01	Nonsignificant	1.00	0.47	Other	30	81
106	NEU.EXC_IT	0.01	Nonsignificant	1.00	0.80	Other	411	192
107	B.memory	0.01	Nonsignificant	1.00	0.88	Other	442	882
108	EPI.colonic_enteroendocrine	0.01	Nonsignificant	—	0.00	Other	1	1
109	EPI.colonocyte	0.01	Nonsignificant	1.00	0.36	Other	294	815
110	T.CD4_Trm	9.47e-03	Nonsignificant	0.83	1.05	Other	176	363
111	MG.microglia	8.98e-03	Nonsignificant	—	—	Other	49	0
112	T.CD4_Tcm	8.70e-03	Nonsignificant	0.49	1.08	Other	494	988
113	EPI.skin_appendage_keratinocyte	8.58e-03	Nonsignificant	1.00	0.46	Other	87	222
114	MAC.proliferating	8.15e-03	Nonsignificant	1.00	0.73	Other	87	253
115	ILC2.innate_lymphoid_cell_2	8.13e-03	Nonsignificant	—	—	Other	2	0
116	FIB.hepatic_stellate_cell	7.89e-03	Nonsignificant	—	0.00	Other	64	252
117	CM.cardiomyocyte	7.83e-03	Nonsignificant	—	—	Other	524	2,032
118	T.CD4_naive	7.60e-03	Nonsignificant	1.00	0.98	Other	399	866
119	EPI.skin_interfollicular_spinous	7.40e-03	Nonsignificant	1.00	0.59	Other	260	563
120	T.CD8_naive	7.35e-03	Nonsignificant	1.00	0.96	Other	317	708
121	EPI.pancreatic_ductal_perivascular	7.18e-03	Nonsignificant	1.00	0.47	Other	4	30
122	EPI.renal_intercalated_cell_type_B	7.15e-03	Nonsignificant	—	0.00	Other	6	7
123	SKM.type_2_fast	5.45e-03	Nonsignificant	0.35	1.08	Other	972	2,639
124	EPI.thymic_medullary	5.39e-03	Nonsignificant	1.00	0.37	Other	26	133
125	T.CD4_Tfh	4.63e-03	Nonsignificant	1.00	0.97	Other	47	45
126	CHOND.chondrocyte	2.80e-03	Nonsignificant	—	—	Other	519	730
127	EPI.esophageal_suprabasal	2.46e-03	Nonsignificant	1.00	0.30	Other	158	404
128	EPI.renal_distal_tubule	2.39e-03	Nonsignificant	1.00	0.38	Other	133	361
129	EPI.renal_intercalated_cell_type_A	2.19e-03	Nonsignificant	1.00	0.26	Other	67	142
130	T.CD8_Trm	1.81e-03	Nonsignificant	1.00	0.88	Other	211	346
131	SKM.type_1_slow	1.73e-03	Nonsignificant	0.88	0.87	Other	923	2,478
132	HEP.canalicular_transport	1.31e-03	Nonsignificant	0.16	1.06	Other	1,290	3,434
133	T.CD8_transitional	1.15e-03	Nonsignificant	1.00	0.96	Other	497	932
134	DC.pDC	9.65e-04	Nonsignificant	1.00	0.72	Other	496	1,028
135	T.CD4_Tem	9.10e-04	Nonsignificant	1.00	0.94	Other	365	697
136	B.germinal_center	7.36e-04	Nonsignificant	1.00	0.61	Other	233	655
137	HEP.acute_phase	6.61e-04	Nonsignificant	0.57	1.02	Other	1,441	3,641
138	T.gamma_delta	6.53e-04	Nonsignificant	1.00	1.00	Other	588	1,078
139	EPI.salivary_myoepithelial	6.30e-04	Nonsignificant	1.00	0.23	Other	191	714
140	T.CD4_Treg	6.29e-04	Nonsignificant	1.00	0.74	Other	244	511
141	EPI.lung_multiciliated	6.00e-04	Nonsignificant	1.00	0.34	Other	16	49
142	EPI.pancreatic_ductal_progenitor	5.94e-04	Nonsignificant	1.00	0.38	Other	234	873
143	HEP.periportal_metabolic	2.77e-04	Nonsignificant	0.81	0.96	Other	1,750	4,427
144	MAC.microglia_like	1.97e-04	Nonsignificant	1.00	0.61	Other	124	179
145	NEU.EXC_SYT2	1.67e-04	Nonsignificant	—	0.00	Other	40	77
146	NEU.EXC_CT	7.96e-05	Nonsignificant	1.00	0.26	Other	362	384
147	T.CD8_Tcm	5.55e-05	Nonsignificant	1.00	0.65	Other	460	926
148	EPI.salivary_mucous_acinar	3.94e-05	Nonsignificant	1.00	0.20	Other	639	1,189
149	NEU.EXC_NTNG1	2.78e-05	Nonsignificant	—	0.00	Other	0	0
150	T.CD4_cytotoxic	5.53e-06	Nonsignificant	1.00	0.56	Other	855	1,493
151	EPI.thymic_cortical	1.84e-06	Nonsignificant	1.00	0.14	Other	442	824
152	MAC.alveolar	1.69e-06	Nonsignificant	1.00	0.26	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar.metabolic_onecarbon	24.30	Significant	5.95e-07	2.54	—	287	328
2	EPI.pancreatic_acinar.adhesion_remodeling	19.73	Significant	0.42	1.39	Specific	210	784
3	OPC.homeostatic	18.20	Significant	4.17e-03	2.31	—	394	160
4	EPI.pancreatic_acinar.quiet_dedifferentiation	14.71	Significant	1.00	0.56	—	142	171
5	EPI.pancreatic_acinar.baseline	14.54	Significant	1.00	0.44	—	274	163
6	OPC.proliferative_immune_interact	14.13	Significant	1.00	0.75	Relevant	180	373
7	EPI.pancreatic_acinar.stress	13.57	Significant	0.47	1.25	—	28	28
8	OPC.premyelinating	12.22	Significant	1.00	0.00	—	185	12
9	IPSC.mesenchymal_primed	10.61	Significant	3.64e-12	1.88	Relevant	0	0
10	EC.venous.remodeling_stalk	9.63	Significant	2.18e-05	1.77	Specific	559	566
11	IPSC.neural_primed	8.07	Significant	0.01	1.46	Relevant	0	0
12	GRNLSA.angiocrine_mechanosensory	7.85	Significant	—	2.33	Relevant	0	0
13	FIB.transitioning.ISG_primed_interface	7.75	Significant	—	0.56	Relevant	17	80
14	IPSC.midbrain_primed	7.44	Significant	0.23	1.34	Relevant	0	0
15	EC.capillary.angiogenic_tip	7.29	Significant	2.13e-05	2.54	Specific	186	218
16	IPSC.endoderm_primed	6.84	Significant	0.43	1.28	Relevant	0	0
17	EC.arterial.angiogenic_tip	6.68	Significant	—	1.61	Specific	30	37
18	EPI.bile_duct_cholangiocyte.secretory_mucin	6.67	Significant	—	0.76	Relevant	7	12
19	EPI.alveolar_type_1.activated	6.57	Significant	—	1.64	Relevant	0	0
20	MEL.mature_oxidative_traffic	6.44	Significant	5.48e-04	2.06	Specific	247	285
21	FIB.transitioning.matrix_stress	6.44	Significant	—	2.78e-17	Other	47	138
22	IPSC.proliferative	6.00	Significant	0.06	1.26	Relevant	0	0
23	EPI.pancreatic_acinar.inflammatory_regenerative	5.89	Significant	1.00	0.00	Other	25	113
24	EPI.alveolar_type_1.baseline	5.47	Nominal	1.00	0.00	—	8	0
25	EC.venous.quiescent_homeostatic	5.28	Nominal	1.91e-04	1.60	Other	456	360
26	FIB.transitioning.secretory_procollagen	5.13	Nominal	—	0.00	Other	0	0
27	IPSC.stromal_primed	5.05	Nominal	1.00	0.95	Other	0	0
28	EC.liver_sinusoidal.hypoxia_metabolic	4.90	Nominal	7.15e-04	2.07	Other	183	107
29	EC.liver_sinusoidal.remodeling_lipotoxicity	4.88	Nominal	—	0.98	Other	90	58
30	EC.heart_remodeling.capillary_metabolic	4.87	Nominal	0.08	1.68	Other	54	414
31	IPSC.stress	4.87	Nominal	0.62	1.11	Other	0	0
32	PLAT.megakaryocytic	4.77	Nominal	—	0.97	Other	0	0
33	EC.arterial.arteriole_gas_exchange	4.41	Nominal	2.50e-03	1.80	Other	238	131
34	EC.arterial.ion_pump	4.38	Nominal	0.16	1.60	Other	3	2
35	IPSC.axial_identity_primed	4.24	Nominal	1.00	0.59	Other	0	0
36	FIB.transitioning.motility_remodelling	4.17	Nominal	—	0.00	Other	0	0
37	EC.arterial.mito_contact	4.11	Nominal	0.58	1.19	Other	14	5
38	EC.capillary.inflammatory	4.05	Nominal	1.00	0.63	Other	27	51
39	EPI.bile_duct_cholangiocyte.inflammatory_APC	4.04	Nominal	—	0.00	Other	2	0
40	EC.capillary.baseline	3.89	Nominal	0.71	1.03	Other	246	560
41	ASTRO.A2_reactive	3.87	Nominal	0.82	1.10	Other	10	37
42	EC.capillary.angiocrine	3.86	Nominal	0.65	1.27	Other	250	630
43	GRNLSA.stress_metabolic	3.85	Nominal	—	0.50	Other	1	2
44	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	3.82	Nominal	0.31	1.25	Other	449	1,034
45	GRNLSA.EMT_insulin_signaling	3.71	Nominal	0.38	1.40	Other	47	84
46	EC.liver_sinusoidal.prostanoid	3.62	Nominal	—	0.25	Other	11	64
47	GRNLSA.proliferative_migratory	3.60	Nominal	0.58	1.17	Other	248	292
48	GRNLSA.p53_damage	3.57	Nominal	—	0.48	Other	13	10
49	IPSC.mesodermal_primed	3.53	Nominal	1.00	0.62	Other	0	0
50	EC.capillary.activated	3.47	Nominal	0.71	1.17	Other	2	5
51	GRNLSA.lipid_hypoxia	3.47	Nominal	0.38	1.40	Other	28	0
52	EC.arterial.arteriole_interface	3.44	Nominal	0.58	1.18	Other	31	12
53	EC.heart_remodeling.remodeling_secretory	3.41	Nominal	0.05	1.56	Other	605	1,341
54	ASTRO.homeostatic	3.40	Nominal	0.75	1.19	Other	200	431
55	EC.capillary.migratory	3.39	Nominal	0.71	1.08	Other	181	509
56	FIB.reticular.ECM_builder	3.39	Nominal	—	0.57	Other	0	0
57	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	3.35	Nominal	—	0.00	Other	0	0
58	MEL.dedifferentiated_migratory	3.34	Nominal	—	0.00	Other	0	0
59	EC.heart_remodeling.perivascular	3.30	Nominal	0.08	1.44	Other	124	408
60	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	3.22	Nominal	—	0.00	Other	0	0
61	EC.capillary.stress	3.18	Nominal	1.00	0.33	Other	44	36
62	ASTRO.stress_mito	3.11	Nominal	1.00	1.00	Other	47	110
63	ASTRO.synaptic_interaction	3.04	Nominal	0.76	1.13	Other	76	334
64	EC.liver_sinusoidal.stress	2.99	Nonsignificant	—	0.00	Other	413	158
65	EC.capillary.postcap_venule	2.93	Nonsignificant	1.00	0.17	Other	355	261
66	HPC.MPP_IEG	2.79	Nonsignificant	0.74	1.12	Other	45	46
67	MEL.secretory_quiescent	2.79	Nonsignificant	0.97	0.41	Other	19	13
68	EC.arterial.metabolic	2.77	Nonsignificant	1.00	0.73	Other	195	159
69	PERI.angiocrine	2.76	Nonsignificant	3.58e-05	2.38	Other	93	102
70	FIB.reticular.stress_metallothionein	2.69	Nonsignificant	—	0.47	Other	3	32
71	MEL.stress_glucocorticoid	2.59	Nonsignificant	0.97	0.68	Other	11	34
72	IPSC.mesendo_primed	2.54	Nonsignificant	1.00	0.30	Other	0	0
73	FIB.adventitial.mechano_chemo_sensing	2.49	Nonsignificant	1.03e-04	1.84	Other	135	524
74	EC.liver_sinusoidal.inflammatory	2.44	Nonsignificant	—	0.00	Other	223	154
75	FIB.tracheal_subepithelial.baseline	2.43	Nonsignificant	—	0.00	Other	0	0
76	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.42	Nonsignificant	—	1.15	Other	0	0
77	HPC.LMPP	2.40	Nonsignificant	0.74	1.09	Other	65	31
78	EC.lymphatic.activated	2.38	Nonsignificant	0.58	1.09	Other	47	73
79	EC.arterial.inflammatory	2.34	Nonsignificant	1.00	0.40	Other	63	50
80	EC.venous.cardiac_structural	2.27	Nonsignificant	1.00	0.93	Other	102	229
81	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.26	Nonsignificant	—	0.00	Other	0	0
82	FIB.reticular.immune_interface	2.25	Nonsignificant	—	0.41	Other	1	6
83	EC.arterial.homeostatic	2.24	Nonsignificant	1.00	0.36	Other	24	3
84	MEL.neurotrophic_migratory	2.23	Nonsignificant	—	0.00	Other	0	0
85	EPI.extrahepatic_cholangiocyte.barrier_interface	2.17	Nonsignificant	—	0.73	Other	0	0
86	EPI.hepatic_ductular_cholangiocyte.stress	2.09	Nonsignificant	—	1.32	Other	0	0
87	ASTRO.immature_lipid	2.09	Nonsignificant	1.00	0.85	Other	23	113
88	EC.heart_remodeling.remodeling_stalk	2.05	Nonsignificant	1.00	0.62	Other	33	111
89	EC.lymphatic.tip_migratory	2.05	Nonsignificant	0.58	1.13	Other	23	37
90	PERI.baseline	2.01	Nonsignificant	0.67	1.11	Other	39	66
91	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.98	Nonsignificant	—	1.13	Other	0	0
92	MONO.CD14.platelet_bound	1.97	Nonsignificant	0.05	1.36	Other	964	176
93	PERI.inflammatory	1.93	Nonsignificant	0.98	0.44	Other	40	77
94	GRNLSA.cholesterol_mevalonate	1.92	Nonsignificant	1.00	0.32	Other	9	4
95	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.90	Nonsignificant	—	1.36	Other	0	0
96	PERI.cardiac_skeletal	1.86	Nonsignificant	0.98	0.43	Other	313	630
97	SMC.metabolic	1.85	Nonsignificant	2.69e-04	2.06	Other	14	40
98	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.77	Nonsignificant	—	0.00	Other	0	0
99	GRNLSA.secretory_remodeling	1.75	Nonsignificant	1.00	0.27	Other	90	25
100	FIB.adventitial.complement_angiocrine	1.70	Nonsignificant	0.07	1.40	Other	153	684
101	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.70	Nonsignificant	—	0.97	Other	0	0
102	OLG.myelinating_mature	1.64	Nonsignificant	1.12e-03	1.41	Other	363	94
103	MONO.CD14.APC_like	1.64	Nonsignificant	1.79e-07	1.62	Other	1,686	2,493
104	EC.venous.baseline	1.64	Nonsignificant	1.00	0.87	Other	346	807
105	IPSC.neuroendocrine_primed	1.64	Nonsignificant	—	0.00	Other	0	0
106	HPC.MPP_activated	1.58	Nonsignificant	—	0.54	Other	0	0
107	OLG.myelinating_stress	1.57	Nonsignificant	0.34	1.13	Other	232	62
108	EC.heart_remodeling.angiocrine	1.53	Nonsignificant	1.00	0.42	Other	182	525
109	OLG.vesicle_trafficking	1.52	Nonsignificant	0.09	1.36	Other	124	10
110	NEU.INH_LAMP5.exc_inh_balance	1.50	Nonsignificant	—	0.64	Other	46	2
111	EC.lymphatic.baseline	1.43	Nonsignificant	0.65	1.00	Other	38	72
112	OLG.reactive_repair	1.42	Nonsignificant	0.31	1.19	Other	385	385
113	ASTRO.hypoxia_angiogenic	1.42	Nonsignificant	1.00	0.82	Other	5	18
114	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	1.40	Nonsignificant	—	0.00	Other	0	0
115	EPI.skin_hair_follicle_companion.activated_migratory	1.40	Nonsignificant	—	0.00	Other	0	0
116	ASPC.mesothelial_like	1.37	Nonsignificant	0.15	1.56	Other	143	486
117	FIB.neurolectin_mucosa.remodeling_repair	1.35	Nonsignificant	—	0.44	Other	4	2
118	NEU.INH_LAMP5.glial_interface	1.34	Nonsignificant	—	0.58	Other	0	0
119	FIB.adventitial.baseline	1.34	Nonsignificant	1.00	0.91	Other	157	278
120	FIB.interstitial.remodeling	1.33	Nonsignificant	9.44e-03	1.70	Other	31	9
121	FIB.interstitial.stress_secretory	1.32	Nonsignificant	0.33	1.36	Other	92	56
122	EC.heart_remodeling.translation_boost	1.24	Nonsignificant	—	0.00	Other	0	0
123	THYMO.proliferative_S	1.21	Nonsignificant	0.64	1.17	Other	163	418
124	ADIPO.thermogenic	1.20	Nonsignificant	—	1.28	Other	0	0
125	EPI.skin_sweat_duct_keratinocyte.barrier	1.20	Nonsignificant	—	0.76	Other	0	0
126	OLG.stress	1.18	Nonsignificant	0.56	1.03	Other	232	8
127	SMC.activated	1.18	Nonsignificant	0.94	0.85	Other	2	5
128	EC.liver_sinusoidal.secretory_lipoprotein	1.15	Nonsignificant	1.00	0.00	Other	120	70
129	FIB.neurolectin_mucosa.nerve_interface	1.14	Nonsignificant	—	0.35	Other	4	0
130	MONO.CD16.platelet_bound	1.07	Nonsignificant	0.34	1.28	Other	372	508
131	MONO.CD14.remodeling	1.05	Nonsignificant	4.09e-03	1.25	Other	2,373	295
132	FIB.adventitial.PI16_matrix	1.03	Nonsignificant	1.00	0.63	Other	70	90
133	ASPC.stem_like_progenitor	1.03	Nonsignificant	0.07	1.49	Other	300	842
134	EC.arterial.elastic	1.02	Nonsignificant	1.00	0.00	Other	22	45
135	SMC.contractile	1.01	Nonsignificant	0.94	0.57	Other	80	588
136	ASPC.niche_keeping_progenitor	1.01	Nonsignificant	0.06	1.47	Other	52	219
137	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.00	Nonsignificant	—	0.67	Other	0	0
138	NEU.INH_LAMP5.rosehip	1.00	Nonsignificant	—	0.00	Other	0	0
139	FIB.reticular.stromal_niche	0.99	Nonsignificant	0.82	0.71	Other	0	0
140	FIB.interstitial.mesenchymal_APC	0.99	Nonsignificant	0.30	1.36	Other	81	33
141	FIB.adventitial.mito_secretory	0.97	Nonsignificant	1.00	0.60	Other	21	7
142	FIB.interstitial.immune_interact	0.96	Nonsignificant	1.00	0.67	Other	12	1
143	EC.venous.activated	0.96	Nonsignificant	1.00	0.70	Other	247	752
144	ADIPO.hypoxia_remodelling	0.95	Nonsignificant	—	0.29	Other	29	105
145	EPI.endocervical_secretory.secretory_translocon	0.93	Nonsignificant	—	0.67	Other	0	0
146	FIB.interstitial.mesenchymal_regulator	0.92	Nonsignificant	1.00	0.85	Other	4	4
147	EPI.ileal_enterocyte_absorptive.brush_border	0.91	Nonsignificant	2.63e-03	1.79	Other	580	1,717
148	PLAT.adhesion	0.91	Nonsignificant	—	0.00	Other	0	0
149	GRNLSA.chemokine_mechanosensory	0.89	Nonsignificant	1.00	0.00	Other	1	0
150	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.88	Nonsignificant	—	0.00	Other	0	0
151	ASPC.signal_integrator	0.88	Nonsignificant	—	0.14	Other	0	0
152	FIB.adventitial.adhesion_lipid	0.87	Nonsignificant	1.00	0.51	Other	58	209
153	MAC.resident_iron.APC_iron_sensing	0.86	Nonsignificant	0.57	1.17	Other	211	114
154	FIB.perivascular_interface.lipid_shuttle	0.84	Nonsignificant	—	0.00	Other	51	170
155	FIB.lung_alveolar.mito_secretory	0.82	Nonsignificant	—	0.48	Other	0	0
156	FIB.perivascular_interface.vasomotor_tone	0.78	Nonsignificant	—	0.32	Other	0	0
157	FIB.neurolectin_mucosa.inflammatory	0.78	Nonsignificant	0.65	1.06	Other	52	110
158	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.77	Nonsignificant	—	0.00	Other	0	0
159	FIB.neurolectin_mucosa.axon_responsive	0.75	Nonsignificant	0.65	0.86	Other	10	10
160	ASPC.baseline	0.75	Nonsignificant	0.01	1.33	Other	363	170
161	FIB.interstitial.lipid_matrix	0.75	Nonsignificant	1.00	0.37	Other	258	191
162	HPC.GMP_inflammatory	0.75	Nonsignificant	1.00	0.69	Other	20	10
163	EPI.salivary_duct_excretory.stress	0.74	Nonsignificant	0.82	0.99	Other	33	68
164	EPI.skin_hair_follicle_bulge.anagen_growth	0.73	Nonsignificant	—	1.80	Other	0	0
165	FIB.perivascular_interface.vascular_BM_remodelling	0.72	Nonsignificant	—	0.00	Other	0	0
166	NEU.INH_LAMP5.projecting	0.72	Nonsignificant	—	0.00	Other	0	0
167	EPI.skin_sweat_duct_keratinocyte.repair	0.71	Nonsignificant	—	0.19	Other	0	0
168	FIB.skin_sheath.neuro_vascular_interface	0.71	Nonsignificant	—	1.03	Other	0	0
169	PC.IgG_systemic.stress	0.70	Nonsignificant	—	0.71	Other	1	5
170	EPI.salivary_duct_excretory.baseline	0.70	Nonsignificant	0.82	0.49	Other	23	57
171	MUSC.activated_migratory	0.68	Nonsignificant	0.56	1.51	Other	6	7
172	FIB.lung_alveolar.stress_interacting	0.68	Nonsignificant	—	0.00	Other	0	0
173	EPI.salivary_serous_acinar.quiescent	0.67	Nonsignificant	0.02	1.80	Other	178	493
174	EPI.pancreatic_islet.delta	0.65	Nonsignificant	—	1.04	Other	0	0
175	HPC.GMP_granulocytic	0.65	Nonsignificant	—	0.00	Other	3	3
176	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.63	Nonsignificant	—	0.58	Other	0	0
177	FIB.barrier_secretory.remodeling	0.63	Nonsignificant	—	0.26	Other	0	0
178	OLG.regulatory	0.62	Nonsignificant	1.00	0.39	Other	353	73
179	FIB.suburothelial.homeostasis_matrix	0.62	Nonsignificant	0.08	1.94	Other	258	921
180	GRANU.MAST.activated_repair	0.61	Nonsignificant	—	0.64	Other	0	1
181	MUSC.quiescent_reservoir	0.61	Nonsignificant	0.81	0.91	Other	2	8
182	IPSC.canonical_pluripotent	0.61	Nonsignificant	1.00	0.00	Other	0	0
183	ASPC.adipocyte_capillary_interface	0.61	Nonsignificant	0.78	1.12	Other	21	54
184	MONO.CD14.baseline	0.61	Nonsignificant	1.00	0.55	Other	2,268	76
185	EPI.salivary_intercalated_defense.inflammatory	0.61	Nonsignificant	3.06e-04	2.16	Other	152	360
186	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.61	Nonsignificant	0.49	1.18	Other	219	533
187	ASPC.proliferative	0.61	Nonsignificant	1.00	0.92	Other	33	85
188	EC.heart_remodeling.activated_acute	0.59	Nonsignificant	1.00	0.02	Other	102	186
189	PC.IgG_systemic.interacting	0.58	Nonsignificant	0.66	1.06	Other	0	0
190	ASPC.secretory	0.57	Nonsignificant	1.00	0.80	Other	76	5
191	PC.IgG_systemic.metabolic	0.56	Nonsignificant	0.66	1.07	Other	46	63
192	MUSC.early_activation	0.55	Nonsignificant	0.70	1.18	Other	4	32
193	EC.venous.adipose_lipid	0.55	Nonsignificant	1.00	0.26	Other	254	476
194	EPI.ileal_bile_transport.detox_transcytosis	0.55	Nonsignificant	—	0.45	Other	0	1
195	FIB.skin_tenogenic.baseline	0.55	Nonsignificant	—	0.00	Other	0	2
196	EPI.gastric_foveolar.baseline	0.54	Nonsignificant	—	0.00	Other	0	0
197	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.53	Nonsignificant	—	0.00	Other	0	0
198	FIB.barrier_purinergic.stress_GF_binding	0.52	Nonsignificant	—	0.97	Other	0	0
199	GRANU.MAST.resting_granule	0.51	Nonsignificant	—	3.70e-17	Other	0	0
200	EPI.renal_thick_ascending_limb.salt_sensing	0.51	Nonsignificant	0.50	1.26	Other	73	103
201	B.age_associated.activated	0.51	Nonsignificant	—	0.83	Other	18	22
202	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.50	Nonsignificant	—	0.00	Other	0	0
203	THYMO.proliferative_G2M	0.49	Nonsignificant	—	1.54	Other	164	413
204	FIB.adventitial.inflammatory_activated	0.49	Nonsignificant	1.00	0.04	Other	100	473
205	EPI.ileal_bile_transport.absorptive_xenobiotic	0.48	Nonsignificant	0.83	0.42	Other	11	12
206	EPI.skin_keratinocyte_basal.spinous_transition	0.48	Nonsignificant	—	0.97	Other	0	0
207	EPI.pancreatic_islet.beta	0.47	Nonsignificant	0.48	1.09	Other	42	57
208	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.47	Nonsignificant	—	1.06	Other	0	0
209	ASPC.remodeling	0.46	Nonsignificant	1.00	0.77	Other	106	354
210	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.46	Nonsignificant	—	0.00	Other	0	0
211	FIB.skin_sheath.ECM_immune	0.46	Nonsignificant	—	0.00	Other	0	0
212	FIB.skin_papillary.baseline	0.45	Nonsignificant	—	0.00	Other	0	0
213	FIB.adventitial.activated_remodelling	0.45	Nonsignificant	—	0.00	Other	141	319
214	FIB.barrier_secretory.homeostasis	0.45	Nonsignificant	—	0.00	Other	0	0
215	FIB.skin_sheath.stress_chaperone	0.43	Nonsignificant	—	0.00	Other	0	0
216	ASPC.preadipocyte_lipid_primed	0.43	Nonsignificant	1.00	0.42	Other	331	129
217	MUSC.baseline	0.43	Nonsignificant	0.98	0.16	Other	0	0
218	EPI.skin_keratinocyte_basal.transit_amplifying	0.41	Nonsignificant	—	0.00	Other	0	0
219	MESO.secretory_structural	0.41	Nonsignificant	—	0.16	Other	0	0
220	FIB.suburothelial.urothelial_interface	0.41	Nonsignificant	0.69	0.73	Other	9	8
221	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.40	Nonsignificant	0.73	1.09	Other	58	89
222	FIB.suburothelial.contractile_myofibroblast	0.39	Nonsignificant	—	0.00	Other	9	0
223	EPI.salivary_serous_acinar.secretory_active	0.39	Nonsignificant	0.50	0.98	Other	242	69
224	EPI.renal_proximal_tubule.detox_antioxidant	0.39	Nonsignificant	0.73	0.62	Other	394	77
225	EPI.ectocervical_granular.inflammatory	0.39	Nonsignificant	—	1.15	Other	0	0
226	EPI.ileal_enterocyte_crypt.bile_transport	0.38	Nonsignificant	0.48	1.25	Other	2	0
227	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.37	Nonsignificant	—	0.00	Other	6	9
228	FIB.suburothelial.inflammatory_prostanoid	0.36	Nonsignificant	—	0.00	Other	0	0
229	EPI.ileal_enterocyte_absorptive.villus_tip	0.36	Nonsignificant	0.86	0.68	Other	4	3
230	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.35	Nonsignificant	—	0.00	Other	5	3
231	EPI.lung_club_secretory.canonical_surfactant	0.34	Nonsignificant	—	0.75	Other	74	104
232	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.33	Nonsignificant	—	0.00	Other	43	26
233	EPI.lung_club_secretory.ciliogenesis_primed	0.32	Nonsignificant	—	0.37	Other	0	0
234	EPI.ectocervical_granular.secretory_apocrine	0.32	Nonsignificant	—	0.32	Other	0	0
235	MESO.activated_migratory	0.31	Nonsignificant	—	0.28	Other	0	0
236	MONO.CD16.inflammatory	0.31	Nonsignificant	0.05	1.23	Other	1,640	168
237	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.30	Nonsignificant	—	0.00	Other	0	0
238	FIB.barrier_purinergic.lipid_secretory	0.29	Nonsignificant	—	0.00	Other	0	0
239	FIB.skin_neurosecretory.baseline	0.29	Nonsignificant	—	0.00	Other	0	0
240	EPI.hepatic_ductular_cholangiocyte.polarity	0.28	Nonsignificant	—	0.00	Other	0	0
241	EPI.tracheal_basal.activated_stress	0.28	Nonsignificant	0.34	1.42	Other	32	0
242	GRANU.MAST.activated_acute	0.27	Nonsignificant	—	0.00	Other	0	0
243	ADIPO.immature	0.27	Nonsignificant	—	0.00	Other	24	40
244	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.27	Nonsignificant	0.98	0.22	Other	11	22
245	MESO.activated_stress	0.25	Nonsignificant	—	0.32	Other	0	0
246	MAC.LAM.lipid_opsonization	0.25	Nonsignificant	0.47	1.12	Other	45	14
247	EPI.renal_immature_ureteric_bud.defense_secretory	0.25	Nonsignificant	0.65	1.12	Other	45	76
248	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.25	Nonsignificant	—	0.00	Other	0	0
249	EPI.colonic_tuft.homeostatic	0.24	Nonsignificant	—	0.42	Other	0	0
250	MAC.resident_cardiac.antigen_presenting	0.24	Nonsignificant	0.05	1.83	Other	52	27
251	MAC.resident_repair.stress_iron	0.24	Nonsignificant	0.42	1.20	Other	48	97
252	SCHWN.reactive_inflammatory	0.24	Nonsignificant	—	1.14	Other	0	0
253	MONO.CD16.hepatic_mac_like	0.23	Nonsignificant	0.34	1.13	Other	803	117
254	EPI.renal_thick_ascending_limb.cation_flux	0.23	Nonsignificant	0.55	1.13	Other	57	95
255	NEU.INH_VIP.LAMP5_hybrid	0.23	Nonsignificant	—	1.75	Other	1	9
256	OLG.regulatory_activated	0.23	Nonsignificant	1.00	0.16	Other	196	614
257	ASTRO.neuromodulatory	0.23	Nonsignificant	1.00	0.42	Other	34	172
258	EPI.skin_keratinocyte_progenitor.activated_stress	0.22	Nonsignificant	—	0.38	Other	0	0
259	EPI.ileal_goblet.baseline	0.22	Nonsignificant	0.08	1.96	Other	16	2
260	DC.cDC2.monocyte_like	0.22	Nonsignificant	1.00	1.08	Other	1,285	791
261	EPI.tracheal_basal.homeostatic_progenitor	0.22	Nonsignificant	0.86	0.51	Other	285	74
262	MAC.resident_repair.chemokine_angiocrine	0.22	Nonsignificant	0.42	1.17	Other	87	138
263	EPI.colonic_tuft.activated	0.21	Nonsignificant	—	0.00	Other	0	0
264	EPI.endocervical_secretory.squamous_barrier	0.21	Nonsignificant	—	0.00	Other	0	0
265	MAC.resident_repair.ECM_stromal_crosstalk	0.21	Nonsignificant	0.42	1.16	Other	95	158
266	NK.cytokine_repair_primed	0.21	Nonsignificant	0.06	1.11	Other	266	11
267	B.age_associated.migratory	0.21	Nonsignificant	0.84	0.60	Other	2	2
268	MAC.resident_cardiac.phagocytic_homeostasis	0.21	Nonsignificant	0.09	1.51	Other	564	1,221
269	ASPC.inflammatory	0.20	Nonsignificant	1.00	0.16	Other	21	61
270	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.20	Nonsignificant	0.02	1.76	Other	2	9
271	EPI.tracheal_suprabasal.secretory_immune	0.20	Nonsignificant	—	0.38	Other	0	0
272	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.19	Nonsignificant	—	0.57	Other	0	0
273	EC.lymphatic.valve	0.19	Nonsignificant	—	0.00	Other	0	0
274	MESO.baseline	0.18	Nonsignificant	0.66	0.91	Other	0	6
275	ASPC.activated	0.18	Nonsignificant	1.00	0.28	Other	164	162
276	EPI.esophageal_basal.activated_progenitor	0.17	Nonsignificant	0.04	1.67	Other	1	0
277	SCHWN.translation_boost	0.17	Nonsignificant	—	0.47	Other	8	1
278	MAC.kupffer.tolerogenic	0.17	Nonsignificant	—	1.27	Other	45	49
279	EPI.ectocervical_granular.proliferative_basal	0.16	Nonsignificant	—	0.00	Other	0	0
280	EPI.salivary_duct_ion_transport.baseline	0.16	Nonsignificant	—	—	Other	0	0
281	EPI.ileal_enterocyte_crypt.villus_transition	0.16	Nonsignificant	—	1.05	Other	7	10
282	EPI.ileal_goblet.stress_metallothionein	0.16	Nonsignificant	—	0.00	Other	4	11
283	EPI.ileal_goblet.inflammatory_mucin	0.15	Nonsignificant	0.89	0.35	Other	6	9
284	ASTRO.stress_acute	0.15	Nonsignificant	1.00	0.32	Other	60	56
285	MAC.MDM.complement_resolving	0.15	Nonsignificant	0.04	1.13	Other	440	860
286	EPI.ileal_goblet.immature	0.15	Nonsignificant	—	0.00	Other	0	0
287	DC.cDC1.baseline	0.14	Nonsignificant	—	1.53	Other	0	0
288	PC.IgA_muocsal.plasmablast	0.14	Nonsignificant	0.20	1.24	Other	5	4
289	EPI.skin_keratinocyte_basal.basement_anchoring	0.14	Nonsignificant	—	0.00	Other	0	0
290	T.CD8_Tem.early_helper_like	0.14	Nonsignificant	0.17	1.06	Other	445	755
291	MAC.kupffer.fibrogenic	0.13	Nonsignificant	—	0.88	Other	0	0
292	EPI.renal_thick_ascending_limb.barrier_repair	0.13	Nonsignificant	0.55	1.11	Other	141	284
293	MONO.CD14.repair_M2_like	0.13	Nonsignificant	1.00	0.25	Other	550	1,495
294	EPI.skin_keratinocyte_proliferating.detox_repair	0.12	Nonsignificant	—	0.55	Other	0	0
295	EC.lymphatic.scavenger	0.12	Nonsignificant	1.00	0.40	Other	203	257
296	EPI.tracheal_suprabasal.transitional_wound	0.12	Nonsignificant	—	0.00	Other	16	1
297	NK.adaptive_classII_inhibitory	0.12	Nonsignificant	0.49	1.04	Other	880	154
298	B.age_associated.naive_transitional	0.12	Nonsignificant	—	0.00	Other	0	0
299	EPI.renal_thick_ascending_limb.remodeling	0.12	Nonsignificant	0.79	0.95	Other	152	92
300	NK.immature_bridge	0.12	Nonsignificant	0.49	1.04	Other	117	122
301	DC.cDC2.lipid_metabolic	0.11	Nonsignificant	—	1.08	Other	0	0
302	EPI.colonocyte.goblet_interface	0.10	Nonsignificant	—	1.45	Other	11	21
303	THYMO.SP_CD8_naive_stress	0.10	Nonsignificant	0.93	1.17	Other	1	1
304	EPI.alveolar_type_2.stress_response	0.10	Nonsignificant	4.66e-04	2.02	Other	675	1,562
305	GRANU.neutrophil.antiviral_endotoxin	0.10	Nonsignificant	—	0.64	Other	0	0
306	ASTRO.A1_reactive	0.10	Nonsignificant	1.00	0.22	Other	433	394
307	EPI.renal_principal_cell.canonical_vasopressin	0.10	Nonsignificant	0.50	1.43	Other	2	0
308	MONO.CD16.baseline	0.10	Nonsignificant	1.00	0.85	Other	50	1
309	MESO.antiviral	0.10	Nonsignificant	—	0.00	Other	3	8
310	MAC.resident_cardiac.inflammatory_reparative	0.09	Nonsignificant	0.99	0.13	Other	31	96
311	HPC.CLP_B_primed	0.09	Nonsignificant	—	0.00	Other	0	0
312	DC.cDC2.migratory	0.09	Nonsignificant	1.00	0.99	Other	185	39
313	EPI.ileal_enterocyte_crypt.secretory_precursor	0.08	Nonsignificant	—	0.70	Other	0	0
314	EPI.alveolar_type_2.baseline_surfactant	0.08	Nonsignificant	0.99	0.66	Other	64	9
315	T.CD4_naive.activated_stress	0.08	Nonsignificant	0.41	1.31	Other	339	429
316	MAC.resident_repair.antigen_presenting	0.08	Nonsignificant	1.00	0.56	Other	244	113
317	EPI.skin_sebaceous_duct_luminal.detox_repair	0.08	Nonsignificant	0.91	0.49	Other	137	94
318	EPI.tracheal_submucosal_gland.ductal_luminal	0.08	Nonsignificant	—	0.00	Other	0	0
319	T.MAIT.early_activation	0.07	Nonsignificant	0.44	1.36	Other	57	4
320	EPI.skin_interfollicular_spinous.upper_lipid	0.07	Nonsignificant	—	1.36	Other	6	6
321	EPI.alveolar_type_2.injury_primed	0.07	Nonsignificant	0.99	0.40	Other	434	245
322	T.CD4_Tcm.RNA_control	0.07	Nonsignificant	0.33	1.09	Other	96	4
323	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.07	Nonsignificant	—	0.00	Other	0	0
324	EPI.pancreatic_ductal_bicarbonate.stress	0.07	Nonsignificant	—	0.47	Other	12	33
325	B.naive.restrained	0.07	Nonsignificant	0.36	1.11	Other	183	353
326	GRANU.neutrophil.tissue_patrolling	0.07	Nonsignificant	—	0.52	Other	0	0
327	T.CD4_transitional.tissue_enagement	0.07	Nonsignificant	0.28	1.18	Other	5	11
328	MAC.resident_iron.heme_recycling	0.06	Nonsignificant	—	0.85	Other	30	37
329	DC.cDC2.pro_inflammatory	0.06	Nonsignificant	1.00	1.05	Other	3	5
330	MAC.LAM.anti_inflammatory	0.06	Nonsignificant	0.61	1.06	Other	86	132
331	B.memory.preactivated	0.06	Nonsignificant	0.35	1.13	Other	173	174
332	HPC.MEP	0.06	Nonsignificant	1.00	0.16	Other	599	1,195
333	NEU.EXC_IT.structural	0.06	Nonsignificant	0.31	1.17	Other	171	41
334	PC.IgG_systemic.secretory	0.06	Nonsignificant	1.00	0.03	Other	0	0
335	PC.IgA_muocsal.activated	0.06	Nonsignificant	0.27	1.10	Other	17	8
336	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.06	Nonsignificant	—	0.93	Other	39	82
337	T.CD4_transitional.baseline	0.06	Nonsignificant	0.14	1.12	Other	59	97
338	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.05	Nonsignificant	—	0.41	Other	29	88
339	EPI.salivary_intercalated_defense.basal_EMT	0.05	Nonsignificant	—	0.00	Other	0	0
340	PC.IgA_muocsal.migratory	0.05	Nonsignificant	0.90	0.93	Other	4	1
341	NEU.INH_PVALB.nuclear_reg	0.05	Nonsignificant	0.39	1.12	Other	25	12
342	EPI.cervical_suprabasal.inflammatory_repair	0.05	Nonsignificant	—	0.00	Other	0	0
343	EPI.tracheal_submucosal_gland.acinar_serous	0.05	Nonsignificant	—	0.00	Other	0	0
344	THYMO.SP_CD8_transitional	0.05	Nonsignificant	0.93	1.14	Other	32	75
345	CM.contractile_oxphos	0.05	Nonsignificant	0.89	1.09	Other	6	19
346	T.CD4_naive.neddylation_mitoprot	0.05	Nonsignificant	0.41	1.17	Other	93	56
347	EPI.skin_follicular_keratinizing.root_infundibulum	0.04	Nonsignificant	—	1.34	Other	0	0
348	T.CD8_Tem.stress_adapted	0.04	Nonsignificant	0.62	1.03	Other	607	520
349	GRANU.neutrophil.primed_degranulation	0.04	Nonsignificant	—	0.00	Other	0	0
350	MAC.LAM.inflammatory_APC	0.04	Nonsignificant	0.61	1.00	Other	872	165
351	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.04	Nonsignificant	—	0.00	Other	0	0
352	EPI.pancreatic_ductal_bicarbonate.baseline	0.04	Nonsignificant	0.99	0.84	Other	11	42
353	B.memory.activated	0.04	Nonsignificant	0.35	1.08	Other	105	29
354	PC.IgA_muocsal.baseline	0.04	Nonsignificant	0.90	0.88	Other	3	5
355	DC.mig.baseline	0.04	Nonsignificant	—	0.00	Other	1	0
356	NK.adaptive_HLAE_tuned	0.03	Nonsignificant	0.06	1.05	Other	1,124	189
357	HEP.pericentral_lipoprotein.ApoB_coagulation	0.03	Nonsignificant	—	0.67	Other	0	0
358	B.naive.baseline	0.03	Nonsignificant	0.86	1.08	Other	10	13
359	EPI.renal_immature_ureteric_bud.osmoprotective	0.03	Nonsignificant	0.96	0.78	Other	126	44
360	THYMO.DP_early_stress	0.03	Nonsignificant	—	1.04	Other	0	0
361	NEU.INH_PVALB.chandelier	0.03	Nonsignificant	0.39	1.12	Other	19	16
362	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.03	Nonsignificant	0.99	0.93	Other	14	32
363	MAC.kupffer.stress	0.03	Nonsignificant	0.78	0.80	Other	9	3
364	MONO.CD16.patrolling	0.03	Nonsignificant	1.00	0.32	Other	797	216
365	CHOND.remodeling	0.03	Nonsignificant	—	1.24	Other	5	0
366	NEU.INH_VIP.enkephalinergic	0.03	Nonsignificant	—	1.08	Other	0	0
367	NEU.INH_VIP.develop_niche	0.03	Nonsignificant	—	0.95	Other	0	0
368	MG.expanding	0.03	Nonsignificant	0.02	1.53	Other	2	1
369	HEP.pericentral_lipoprotein.UPR_redox	0.03	Nonsignificant	—	0.00	Other	0	0
370	T.CD4_transitional.APC_interacting	0.03	Nonsignificant	0.28	1.18	Other	10	14
371	T.CD4_Th17.baseline	0.03	Nonsignificant	0.45	1.06	Other	51	5
372	MAC.MDM.inflammatory_phagocytic	0.03	Nonsignificant	0.79	0.95	Other	199	52
373	T.CD4_Th2.precursor	0.02	Nonsignificant	—	0.00	Other	0	0
374	B.naive.antigen_presenting_ready	0.02	Nonsignificant	0.45	1.12	Other	48	73
375	EPI.pancreatic_islet.alpha	0.02	Nonsignificant	—	0.00	Other	152	330
376	MAC.resident_iron.redox_metabolic	0.02	Nonsignificant	0.74	1.03	Other	4	4
377	T.CD8_transitional.stress	0.02	Nonsignificant	—	1.84	Other	24	34
378	B.naive.proteostasis	0.02	Nonsignificant	0.92	0.99	Other	49	69
379	NEU.INH_VIP.serotonergic	0.02	Nonsignificant	—	0.00	Other	9	2
380	T.CD4_Trm.baseline	0.02	Nonsignificant	0.27	1.09	Other	31	21
381	DC.cDC1.proliferative	0.02	Nonsignificant	—	0.89	Other	0	0
382	MAC.LAM.lipid_phagocytosis	0.02	Nonsignificant	0.47	1.10	Other	369	328
383	EPI.colonic_enteroendocrine.Lcell_peptide	0.02	Nonsignificant	—	0.97	Other	0	0
384	EPI.skin_sebaceous_duct_luminal.immune_interface	0.02	Nonsignificant	—	0.00	Other	0	0
385	B.naive.activated	0.02	Nonsignificant	0.92	0.98	Other	77	127
386	T.CD4_Th2.tissue_adapted	0.02	Nonsignificant	—	0.00	Other	0	0
387	T.CD4_transitional.primed_cytotoxic	0.02	Nonsignificant	0.66	0.97	Other	28	30
388	ILC2.migratory	0.02	Nonsignificant	—	0.35	Other	0	0
389	T.CD4_naive.gut_prone	0.02	Nonsignificant	1.00	1.19	Other	35	70
390	THYMO.DN_preTCR	0.02	Nonsignificant	1.00	0.85	Other	41	71
391	NEU.EXC_IT.adhesion	0.02	Nonsignificant	1.00	1.00	Other	252	108
392	EPI.skin_interfollicular_spinous.inflammatory	0.02	Nonsignificant	—	1.31	Other	0	0
393	EPI.ileal_enterocyte_crypt.baseline	0.01	Nonsignificant	0.98	0.81	Other	11	6
394	EPI.colonocyte.ionocyte_BEST4	0.01	Nonsignificant	0.16	1.47	Other	103	188
395	CM.baseline	0.01	Nonsignificant	0.89	1.03	Other	393	0
396	MAC.kupffer.monocyte_like	0.01	Nonsignificant	—	0.14	Other	0	0
397	EPI.esophageal_basal.junctional_barrier	0.01	Nonsignificant	—	0.00	Other	0	0
398	T.CD8_naive.nfkb_related	0.01	Nonsignificant	0.54	1.36	Other	1	0
399	T.CD4_transitional.primed_helper_effector	0.01	Nonsignificant	0.66	0.98	Other	19	43
400	T.CD8_naive.vesicle_secretory	0.01	Nonsignificant	0.54	1.26	Other	42	0
401	MONO.CD14.inflammatory	0.01	Nonsignificant	1.00	0.31	Other	92	134
402	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.01	Nonsignificant	—	0.00	Other	135	290
403	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.01	Nonsignificant	—	0.00	Other	0	0
404	T.CD4_Trm.stress_adaptive	0.01	Nonsignificant	0.48	1.13	Other	8	22
405	B.naive.metabolic	0.01	Nonsignificant	0.98	0.90	Other	50	79
406	DC.cDC1.cross_presenting	0.01	Nonsignificant	—	0.32	Other	0	0
407	EPI.colonocyte.proximal_transport	0.01	Nonsignificant	0.57	1.19	Other	24	12
408	EPI.pancreatic_ductal_perivascular.baseline	0.01	Nonsignificant	0.09	1.22	Other	1	5
409	T.CD8_naive.cytokine_dampened	0.01	Nonsignificant	0.83	1.09	Other	71	4
410	MAC.proliferating.DNA_replication	0.01	Nonsignificant	0.42	1.12	Other	3	6
411	B.naive.remodeling	0.01	Nonsignificant	0.92	0.99	Other	135	230
412	THYMO.SP_CD4_naive	0.01	Nonsignificant	1.00	0.76	Other	65	75
413	T.CD4_Tcm.DC_interact	0.01	Nonsignificant	0.33	1.09	Other	72	32
414	FIB.hepatic_stellate_cell.fibrogenic	0.01	Nonsignificant	—	0.42	Other	0	0
415	B.naive.receptor_recycle	0.01	Nonsignificant	0.98	0.85	Other	51	0
416	EPI.renal_principal_cell.activated_acute	9.70e-03	Nonsignificant	0.96	0.95	Other	29	59
417	T.CD4_Tcm.stress	9.59e-03	Nonsignificant	0.52	1.14	Other	5	11
418	THYMO.CD8aa_IELp	9.47e-03	Nonsignificant	—	0.49	Other	1	7
419	T.CD4_Th17.migratory	9.36e-03	Nonsignificant	0.45	1.10	Other	13	23
420	B.naive.purinergic	9.29e-03	Nonsignificant	0.98	0.88	Other	384	820
421	NEU.INH_VIP.nuclear_reg	9.17e-03	Nonsignificant	—	0.57	Other	20	4
422	T.CD4_Trm.metal_stress	9.06e-03	Nonsignificant	0.68	1.09	Other	34	58
423	T.CD4_Tfh.suppression_exhaustion	8.65e-03	Nonsignificant	0.68	1.02	Other	0	2
424	EPI.renal_distal_tubule.stress	8.47e-03	Nonsignificant	—	0.30	Other	0	0
425	CM.translation_boost_RPL	8.45e-03	Nonsignificant	0.40	1.11	Other	129	1
426	MAC.kupffer.inflammatory	8.40e-03	Nonsignificant	—	0.00	Other	7	4
427	MAC.MDM.APC_dendritic	8.38e-03	Nonsignificant	0.79	0.90	Other	48	15
428	T.CD8_naive.splicing_enriched	8.19e-03	Nonsignificant	0.89	0.96	Other	120	16
429	FIB.hepatic_stellate_cell.contractile	8.05e-03	Nonsignificant	—	0.32	Other	0	0
430	EPI.thymic_medullary.stress_APC	8.04e-03	Nonsignificant	0.48	1.23	Other	2	4
431	EPI.skin_follicular_keratinizing.transit_amplifying	7.67e-03	Nonsignificant	—	0.00	Other	21	49
432	EPI.colonocyte.junction_remodeling	7.55e-03	Nonsignificant	0.88	1.01	Other	218	305
433	MAC.MDM.LAM_like	7.48e-03	Nonsignificant	0.79	1.00	Other	12	14
434	T.CD4_naive.homeostatic	7.42e-03	Nonsignificant	1.00	1.03	Other	215	108
435	EPI.skin_keratinocyte_proliferating.anchor_remodel	7.37e-03	Nonsignificant	—	0.00	Other	0	0
436	T.MAIT.migratory	7.37e-03	Nonsignificant	0.44	1.18	Other	10	1
437	EPI.renal_intercalated_cell_type_A.PC_transitional	7.25e-03	Nonsignificant	—	0.00	Other	203	407
438	EPI.renal_intercalated_cell_type_B.baseline	7.15e-03	Nonsignificant	—	0.00	Other	3	1
439	EPI.pancreatic_ductal_progenitor.ADM_like	7.08e-03	Nonsignificant	—	1.79	Other	0	0
440	T.CD4_Trm.central_like	6.98e-03	Nonsignificant	0.27	1.12	Other	38	31
441	MG.baseline	6.63e-03	Nonsignificant	0.91	0.96	Other	16	5
442	SKM.type_1_slow.glycolytic	6.36e-03	Nonsignificant	0.13	1.29	Other	362	647
443	T.CD8_naive.lipid_synthesis	6.34e-03	Nonsignificant	0.83	1.11	Other	6	4
444	EPI.ileal_enterocyte_crypt.proliferative_S	6.28e-03	Nonsignificant	0.98	0.39	Other	4	2
445	THYMO.DP_early	6.22e-03	Nonsignificant	1.00	0.80	Other	326	313
446	HEP.acute_phase.proliferative	6.19e-03	Nonsignificant	—	0.71	Other	4	6
447	T.CD4_Tfh.canonical_GC_helper	6.15e-03	Nonsignificant	0.68	1.03	Other	1	2
448	T.CD4_Tfh.effector_migratory	6.09e-03	Nonsignificant	0.68	1.06	Other	122	57
449	SKM.type_2_fast.oxidative_IIa	5.86e-03	Nonsignificant	0.56	1.01	Other	946	56
450	EPI.skin_follicular_keratinizing.upper_infundibulum	5.86e-03	Nonsignificant	—	0.00	Other	8	2
451	MAC.resident_repair.lipid_phagocytic	5.76e-03	Nonsignificant	1.00	0.11	Other	228	604
452	SCHWN.axon_contact_cardiac	5.64e-03	Nonsignificant	1.00	0.18	Other	18	63
453	EPI.thymic_medullary.canonical_alarmin	5.63e-03	Nonsignificant	0.48	1.07	Other	8	17
454	EPI.colonocyte.distal_absorptive	5.55e-03	Nonsignificant	—	0.23	Other	0	0
455	DC.cDC2.adhesion_signaling	5.05e-03	Nonsignificant	1.00	0.86	Other	35	9
456	T.CD8_naive.baseline	4.94e-03	Nonsignificant	0.89	0.86	Other	142	2
457	T.MAIT.cytotoxic	4.93e-03	Nonsignificant	0.44	1.24	Other	52	15
458	MAC.resident_iron.heme_catabolism	4.81e-03	Nonsignificant	0.80	0.85	Other	30	51
459	EPI.renal_principal_cell.inflammatory	4.78e-03	Nonsignificant	0.96	1.08	Other	74	157
460	SKM.type_2_fast.glycolytic_IIx_IIb	4.74e-03	Nonsignificant	0.16	1.17	Other	565	1,482
461	T.CD8_transitional.Trm_primed	4.73e-03	Nonsignificant	0.36	1.07	Other	108	15
462	EPI.ileal_enterocyte_crypt.proliferative_G2M	4.62e-03	Nonsignificant	—	0.00	Other	19	54
463	ILC2.activated	4.58e-03	Nonsignificant	—	0.00	Other	0	0
464	T.CD4_naive.mature	4.52e-03	Nonsignificant	1.00	0.97	Other	211	100
465	B.memory.baseline	4.47e-03	Nonsignificant	1.00	0.77	Other	472	99
466	EPI.lung_multiciliated.mature_motile_cilia	4.41e-03	Nonsignificant	—	1.53	Other	0	0
467	EPI.skin_interfollicular_spinous.stress_oxidative	4.30e-03	Nonsignificant	—	0.73	Other	0	0
468	MAC.resident_iron.stress_tolerogenic	4.16e-03	Nonsignificant	—	0.32	Other	0	0
469	T.CD8_naive.effector_transition	4.11e-03	Nonsignificant	0.83	1.05	Other	35	62
470	CM.osmoprotection	3.99e-03	Nonsignificant	0.94	1.05	Other	34	57
471	HEP.periportal_metabolic.apolipoprotein_secretory	3.96e-03	Nonsignificant	0.22	1.25	Other	43	110
472	CM.sarcomere_actin_interface	3.84e-03	Nonsignificant	1.00	1.00	Other	450	78
473	MG.phagocytic_APC	3.76e-03	Nonsignificant	0.95	0.58	Other	25	8
474	FIB.hepatic_stellate_cell.inflammatory	3.74e-03	Nonsignificant	—	0.00	Other	0	0
475	NK.cytokine_lung_immediate_early	3.66e-03	Nonsignificant	1.00	1.07	Other	424	274
476	DC.cDC1.activated	3.65e-03	Nonsignificant	—	0.00	Other	0	0
477	T.CD8_Trm.muscosal_Tc17	3.53e-03	Nonsignificant	0.64	1.10	Other	19	38
478	ILC2.quiescent	3.46e-03	Nonsignificant	—	6.94e-17	Other	0	0
479	NEU.INH_VIP.regulatory_remodeling	3.43e-03	Nonsignificant	—	0.04	Other	6	1
480	HEP.canalicular_transport.pericentral_like_hypoxia	3.32e-03	Nonsignificant	0.53	1.17	Other	326	8
481	B.germinal_center.DZ_M_phase	3.26e-03	Nonsignificant	—	1.47	Other	0	0
482	HEP.periportal_metabolic.stress_chaperone	3.21e-03	Nonsignificant	—	0.27	Other	66	128
483	T.CD8_naive.innate_like	3.21e-03	Nonsignificant	0.89	0.80	Other	10	1
484	EPI.skin_hair_follicle_bulge.quiescent	3.15e-03	Nonsignificant	0.99	0.29	Other	56	69
485	EPI.esophageal_suprabasal.basal_transitional	3.10e-03	Nonsignificant	0.39	1.32	Other	44	67
486	T.CD4_Trm.activated	3.00e-03	Nonsignificant	0.86	0.91	Other	32	26
487	T.CD4_naive.survival	2.96e-03	Nonsignificant	1.00	0.99	Other	12	17
488	T.CD4_Tem.long_term_memory	2.87e-03	Nonsignificant	0.31	1.07	Other	314	587
489	DC.pDC.poised_migratory	2.82e-03	Nonsignificant	0.52	1.16	Other	54	95
490	EPI.thymic_medullary.hormone_xeno_barrier	2.79e-03	Nonsignificant	—	0.00	Other	0	8
491	EPI.renal_principal_cell.intercalated_like	2.78e-03	Nonsignificant	0.96	0.78	Other	63	66
492	EPI.ectocervical_granular.immune_interact	2.72e-03	Nonsignificant	—	0.00	Other	0	0
493	T.CD8_Trm.inflammatory	2.71e-03	Nonsignificant	0.79	1.01	Other	124	176
494	EPI.esophageal_suprabasal.differentiating_keratin	2.61e-03	Nonsignificant	0.53	1.00	Other	131	61
495	T.CD4_Tcm.tissue_homing	2.53e-03	Nonsignificant	0.52	1.09	Other	78	46
496	T.CD4_naive.mature_mitoprot	2.50e-03	Nonsignificant	1.00	0.89	Other	212	476
497	EPI.salivary_myoepithelial.junctional_transport	2.47e-03	Nonsignificant	0.07	1.28	Other	66	121
498	CHOND.articular_collagen	2.42e-03	Nonsignificant	0.91	1.04	Other	551	266
499	EPI.esophageal_suprabasal.proliferative_exit	2.37e-03	Nonsignificant	—	0.51	Other	0	0
500	T.CD4_naive.neddylation	2.29e-03	Nonsignificant	1.00	0.91	Other	104	222
501	T.CD4_Trm.cytotoxic_effector	2.27e-03	Nonsignificant	0.86	0.98	Other	118	77
502	NEU.INH_VIP.canonical_disinhibitory	2.26e-03	Nonsignificant	0.84	0.69	Other	59	38
503	EPI.thymic_medullary.proliferative_APC	2.26e-03	Nonsignificant	—	0.00	Other	0	0
504	T.CD4_Tcm.migratory_cilium	2.26e-03	Nonsignificant	0.52	1.10	Other	5	10
505	EPI.esophageal_suprabasal.proliferative_G2M	2.25e-03	Nonsignificant	—	0.23	Other	0	0
506	NEU.INH_PVALB.metabotropic	2.22e-03	Nonsignificant	—	0.00	Other	0	0
507	T.CD8_Trm.dendritic_recruiter	2.17e-03	Nonsignificant	0.79	0.96	Other	47	85
508	HEP.canalicular_transport.secretory_ERAD_UPR	2.16e-03	Nonsignificant	0.53	1.19	Other	232	28
509	T.CD4_Trm.helper_like	2.15e-03	Nonsignificant	0.87	0.85	Other	84	147
510	MAC.LAM.perivascular_angiocrine	2.10e-03	Nonsignificant	—	0.69	Other	53	138
511	HEP.canalicular_transport.ductular_like_transition	2.03e-03	Nonsignificant	0.54	1.12	Other	400	87
512	EPI.colonocyte.crypt_progenitor	2.03e-03	Nonsignificant	0.99	0.56	Other	115	265
513	T.gamma_delta.early_effector	1.94e-03	Nonsignificant	0.24	1.09	Other	89	0
514	EPI.skin_appendage_keratinocyte.transit_amplifying	1.92e-03	Nonsignificant	—	0.00	Other	109	358
515	CHOND.activated_fibro_like	1.88e-03	Nonsignificant	0.91	0.96	Other	531	188
516	MAC.LAM.antimicrobial	1.86e-03	Nonsignificant	0.61	0.99	Other	389	93
517	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.81e-03	Nonsignificant	0.84	0.58	Other	33	34
518	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	1.76e-03	Nonsignificant	0.84	0.58	Other	7	16
519	T.MAIT.MAPK_brake	1.72e-03	Nonsignificant	0.91	0.90	Other	44	66
520	T.MAIT.vesicle	1.70e-03	Nonsignificant	0.91	0.78	Other	37	65
521	NK.cytokine_tissue_resident	1.69e-03	Nonsignificant	1.00	1.07	Other	74	82
522	T.CD4_Tcm.regulatory_poised	1.66e-03	Nonsignificant	0.79	1.07	Other	2	3
523	EPI.colonocyte.secretory_boost	1.44e-03	Nonsignificant	0.99	0.62	Other	98	91
524	B.memory.migratory	1.36e-03	Nonsignificant	1.00	0.76	Other	123	208
525	THYMO.SP_CD8_naive	1.35e-03	Nonsignificant	1.00	0.28	Other	297	177
526	CM.oxidative_phospho	1.33e-03	Nonsignificant	1.00	0.92	Other	266	792
527	CM.inflammatory	1.31e-03	Nonsignificant	—	0.84	Other	0	0
528	T.CD8_Tem.TEMRA	1.29e-03	Nonsignificant	0.67	1.02	Other	920	1,088
529	T.CD8_Trm.cytotoxic	1.24e-03	Nonsignificant	0.39	1.12	Other	165	85
530	T.CD4_naive.survival_mitoprot	1.21e-03	Nonsignificant	1.00	0.89	Other	13	7
531	T.CD4_naive.survival_neddylation	1.20e-03	Nonsignificant	1.00	0.96	Other	26	38
532	CHOND.angiogenic	1.14e-03	Nonsignificant	—	0.83	Other	0	0
533	T.MAIT.quiescent	1.12e-03	Nonsignificant	0.96	0.61	Other	100	5
534	EPI.renal_distal_tubule.repair	1.10e-03	Nonsignificant	—	0.00	Other	34	102
535	CM.mito_proteostasis	1.08e-03	Nonsignificant	1.00	0.95	Other	329	29
536	NEU.INH_PVALB.fastspike	1.04e-03	Nonsignificant	—	0.00	Other	24	22
537	HEP.acute_phase.complement_antiviral	1.03e-03	Nonsignificant	0.69	1.05	Other	377	751
538	T.CD4_Tfh.precursor_migratory	9.92e-04	Nonsignificant	0.96	0.73	Other	72	27
539	EPI.pancreatic_ductal_bicarbonate.activated	9.90e-04	Nonsignificant	0.99	0.39	Other	10	7
540	T.CD4_naive.proteostasis_mitoprot	9.48e-04	Nonsignificant	1.00	0.88	Other	15	37
541	T.CD8_Trm.homeostatic	9.43e-04	Nonsignificant	0.91	0.86	Other	42	5
542	MAC.proliferating.stress	9.26e-04	Nonsignificant	—	0.00	Other	87	136
543	T.CD4_Th17.cytotoxic	9.22e-04	Nonsignificant	0.77	0.93	Other	332	123
544	NEU.INH_VIP.excitatory_coupled	8.92e-04	Nonsignificant	—	0.00	Other	13	0
545	T.CD4_Tcm.baseline	8.84e-04	Nonsignificant	0.79	1.05	Other	61	31
546	HEP.acute_phase.complement_metabolic	8.73e-04	Nonsignificant	8.06e-07	1.15	Other	1,423	3,464
547	T.CD4_Tcm.imprinted_splicing	8.30e-04	Nonsignificant	0.79	1.05	Other	6	17
548	T.CD8_Tem.baseline	8.18e-04	Nonsignificant	0.67	1.02	Other	458	356
549	T.CD4_Treg.APC_interactive	7.98e-04	Nonsignificant	0.37	1.09	Other	118	28
550	CM.mechano_activated	7.89e-04	Nonsignificant	1.00	0.88	Other	205	134
551	T.CD4_naive.resist_bystander	7.83e-04	Nonsignificant	1.00	0.94	Other	40	25
552	EPI.renal_intercalated_cell_type_A.acid_secretion	7.52e-04	Nonsignificant	0.87	0.62	Other	12	6
553	NEU.INH_VIP.matrix	7.46e-04	Nonsignificant	—	0.00	Other	24	77
554	NEU.EXC_IT.guidance	7.36e-04	Nonsignificant	1.00	0.70	Other	274	63
555	HEP.acute_phase.stress_secretory	7.30e-04	Nonsignificant	0.69	1.13	Other	26	3
556	T.CD4_Tcm.Tfh_like	7.11e-04	Nonsignificant	0.89	1.00	Other	102	214
557	DC.cDC2.proliferative	6.80e-04	Nonsignificant	—	0.00	Other	39	71
558	NEU.INH_PVALB.serotonergic	6.67e-04	Nonsignificant	—	0.00	Other	0	0
559	EPI.salivary_myoepithelial.contractile_repair	6.58e-04	Nonsignificant	—	0.28	Other	3	9
560	T.CD4_Tcm.Th2_like	6.39e-04	Nonsignificant	0.56	1.13	Other	23	55
561	MAC.kupffer.metabolic	6.23e-04	Nonsignificant	—	0.00	Other	25	36
562	T.CD4_naive.Treg_like	6.05e-04	Nonsignificant	1.00	1.15	Other	121	72
563	SKM.type_1_slow.contractile	5.78e-04	Nonsignificant	1.00	0.72	Other	596	8
564	CM.translation_boost_RPS	5.62e-04	Nonsignificant	1.00	0.94	Other	69	16
565	HEP.canalicular_transport.injury_stress	5.49e-04	Nonsignificant	0.86	0.82	Other	289	24
566	T.CD8_naive.mito_proteostasis	5.49e-04	Nonsignificant	0.89	0.68	Other	428	100
567	EPI.renal_thick_ascending_limb.canonical_salt_transporter	5.42e-04	Nonsignificant	1.00	0.08	Other	322	317
568	EPI.esophageal_suprabasal.proliferative_S	5.41e-04	Nonsignificant	—	0.00	Other	26	41
569	HEP.canalicular_transport.inflammatory	5.25e-04	Nonsignificant	0.86	0.93	Other	1,335	194
570	NEU.EXC_IT.callosal	5.21e-04	Nonsignificant	1.00	0.59	Other	286	119
571	T.CD4_Treg.central_naive_like	5.19e-04	Nonsignificant	1.15e-04	1.38	Other	333	45
572	NK.cytokine_axis_baseline	5.04e-04	Nonsignificant	1.00	0.93	Other	1,172	116
573	HEP.periportal_metabolic.stress_checkpoint	4.88e-04	Nonsignificant	1.00	1.09	Other	234	786
574	NEU.EXC_IT.neuromodulated	4.71e-04	Nonsignificant	1.00	0.59	Other	176	116
575	EPI.colonic_enteroendocrine.progenitor	4.49e-04	Nonsignificant	—	0.00	Other	0	0
576	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	4.41e-04	Nonsignificant	0.99	0.39	Other	40	191
577	NEU.INH_VIP.cannabinoid	4.34e-04	Nonsignificant	—	0.00	Other	0	0
578	CHOND.pro_inflammatory	4.33e-04	Nonsignificant	0.91	0.77	Other	181	351
579	T.CD4_Treg.tissue_effector	4.29e-04	Nonsignificant	0.59	0.98	Other	16	13
580	NK.cytokine_quiescent	4.29e-04	Nonsignificant	1.00	0.99	Other	623	1,062
581	B.germinal_center.LZ_selection	4.25e-04	Nonsignificant	—	0.18	Other	0	0
582	T.CD4_Tcm.crosstalk_myeloid	4.22e-04	Nonsignificant	0.89	1.02	Other	5	4
583	T.CD8_transitional.effector_primed	4.19e-04	Nonsignificant	0.86	0.97	Other	435	151
584	EPI.renal_principal_cell.injury_repair	4.08e-04	Nonsignificant	1.00	0.12	Other	26	9
585	MAC.microglia_like.inflammatory_chemokine	4.03e-04	Nonsignificant	—	0.69	Other	20	32
586	T.CD4_naive.proteostasis	3.74e-04	Nonsignificant	1.00	0.68	Other	14	9
587	NK.cytokine_biosynthetic_primed	3.72e-04	Nonsignificant	1.00	1.00	Other	360	21
588	T.CD4_Tem.inflammatory	3.70e-04	Nonsignificant	0.83	0.98	Other	28	6
589	EPI.renal_distal_tubule.ion_transport	3.66e-04	Nonsignificant	—	0.40	Other	0	0
590	B.germinal_center.DZ_S_phase	3.63e-04	Nonsignificant	—	0.21	Other	0	0
591	EPI.skin_interfollicular_spinous.transition_basal	3.31e-04	Nonsignificant	0.92	0.74	Other	100	127
592	HEP.acute_phase.baseline	3.14e-04	Nonsignificant	0.97	0.95	Other	946	19
593	HEP.canalicular_transport.baseline	3.06e-04	Nonsignificant	0.86	0.72	Other	199	477
594	T.CD8_transitional.APC_like	2.81e-04	Nonsignificant	0.86	0.95	Other	205	62
595	EPI.skin_interfollicular_spinous.baseline	2.78e-04	Nonsignificant	0.92	0.77	Other	35	3
596	NEU.EXC_SYT2.synaptic	2.71e-04	Nonsignificant	—	0.00	Other	0	0
597	DC.pDC.immature_metabolic	2.58e-04	Nonsignificant	0.92	0.94	Other	78	124
598	HEP.canalicular_transport.sterol_lipid_biosynthesis	2.39e-04	Nonsignificant	—	0.00	Other	10	20
599	T.CD4_Tcm.effector_like	2.36e-04	Nonsignificant	0.91	0.95	Other	293	533
600	MONO.CD14.cord_tolerance	2.33e-04	Nonsignificant	1.00	0.02	Other	864	753
601	B.memory.pDC_imprint	2.19e-04	Nonsignificant	1.00	0.56	Other	157	103
602	NEU.EXC_CT.remodeling	2.11e-04	Nonsignificant	—	0.44	Other	23	1
603	T.CD8_transitional.early	2.10e-04	Nonsignificant	0.86	0.96	Other	327	55
604	EPI.skin_interfollicular_spinous.stress_UPR	2.02e-04	Nonsignificant	—	0.00	Other	0	0
605	T.MAIT.stress	1.93e-04	Nonsignificant	—	0.00	Other	0	0
606	EPI.lung_club_secretory.inflammatory	1.82e-04	Nonsignificant	—	0.00	Other	0	0
607	NEU.INH_VIP.opioid	1.75e-04	Nonsignificant	—	0.00	Other	50	9
608	EPI.lung_multiciliated.baseline	1.73e-04	Nonsignificant	—	0.51	Other	0	7
609	EPI.skin_interfollicular_spinous.early_differentiation	1.71e-04	Nonsignificant	0.92	0.61	Other	89	19
610	T.CD8_Tcm.NK_like	1.66e-04	Nonsignificant	0.67	1.10	Other	334	581
611	HEP.periportal_metabolic.acute_phase_barrier	1.48e-04	Nonsignificant	1.00	1.04	Other	533	138
612	SKM.type_1_slow.oxidative	1.48e-04	Nonsignificant	1.00	0.09	Other	802	251
613	EPI.salivary_myoepithelial.baseline	1.46e-04	Nonsignificant	0.99	0.70	Other	42	141
614	CM.anti_inflammatory	1.46e-04	Nonsignificant	1.00	0.74	Other	424	1,503
615	T.CD4_naive.purinergic	1.40e-04	Nonsignificant	1.00	0.43	Other	49	1
616	EPI.salivary_serous_acinar.seromucous_like	1.28e-04	Nonsignificant	—	0.00	Other	0	0
617	T.CD8_Tcm.effector_bias	1.08e-04	Nonsignificant	0.02	1.16	Other	199	329
618	T.CD4_Treg.Tr1_like	9.94e-05	Nonsignificant	—	0.00	Other	8	8
619	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	8.33e-05	Nonsignificant	—	0.82	Other	0	0
620	T.CD4_Tem.cytotoxic_effector	7.27e-05	Nonsignificant	0.83	1.01	Other	225	398
621	NEU.EXC_IT.transitional	6.77e-05	Nonsignificant	1.00	0.48	Other	237	142
622	T.gamma_delta.cytotoxic_effector	6.66e-05	Nonsignificant	0.87	0.98	Other	349	109
623	DC.cDC2.tolerogenic_regulatory	6.21e-05	Nonsignificant	1.00	0.59	Other	44	4
624	HEP.periportal_metabolic.inflammatory_activated	6.07e-05	Nonsignificant	1.00	0.94	Other	712	1,610
625	DC.cDC1.homeostatic_inhibitory	6.04e-05	Nonsignificant	—	0.00	Other	0	0
626	T.CD8_Tcm.baseline	5.65e-05	Nonsignificant	0.28	1.10	Other	90	89
627	DC.cDC2.antiviral	5.54e-05	Nonsignificant	1.00	0.57	Other	100	37
628	NEU.EXC_CT.projector	5.48e-05	Nonsignificant	0.52	1.04	Other	87	26
629	EPI.pancreatic_ductal_perivascular.protective_antioxidant	5.40e-05	Nonsignificant	—	0.00	Other	11	69
630	NK.adaptive_immature_precursor	4.96e-05	Nonsignificant	1.00	0.95	Other	358	111
631	NEU.EXC_NTNG1.synaptic	4.49e-05	Nonsignificant	—	0.67	Other	0	0
632	NK.cytokine_tissue_activation	4.18e-05	Nonsignificant	1.00	0.94	Other	267	450
633	T.CD4_Tem.transitional_CM	4.15e-05	Nonsignificant	0.87	0.92	Other	31	20
634	NK.adaptive_axis_baseline	4.07e-05	Nonsignificant	1.00	0.94	Other	1,008	153
635	EPI.salivary_mucous_acinar.baseline	3.94e-05	Nonsignificant	—	—	Other	394	683
636	T.CD8_Tem.signaling_turnover	3.78e-05	Nonsignificant	0.70	1.02	Other	425	683
637	EPI.salivary_myoepithelial.activated	3.45e-05	Nonsignificant	0.99	0.46	Other	85	281
638	T.CD4_Tcm.secretory	3.22e-05	Nonsignificant	0.89	0.98	Other	20	11
639	NEU.INH_PVALB.neuromodulatory	3.19e-05	Nonsignificant	—	0.00	Other	0	0
640	B.germinal_center.LZ_memory_precursor	3.16e-05	Nonsignificant	—	0.00	Other	0	0
641	EPI.cervical_suprabasal.secretory_vesicle	3.11e-05	Nonsignificant	—	0.00	Other	0	0
642	T.CD4_Tcm.APC_mimicry	2.89e-05	Nonsignificant	0.91	0.85	Other	54	43
643	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	2.85e-05	Nonsignificant	—	0.00	Other	49	237
644	EPI.renal_distal_tubule.ciliated_remodelling	2.79e-05	Nonsignificant	—	0.00	Other	0	0
645	HEP.periportal_metabolic.urea_onecarbon_secretory	2.52e-05	Nonsignificant	1.00	0.89	Other	1,332	3,053
646	EPI.lung_club_secretory.ciliogenesis_axoneme	2.06e-05	Nonsignificant	—	0.00	Other	0	0
647	NK.cytokine_vascular_patrolling	2.01e-05	Nonsignificant	1.00	0.85	Other	863	94
648	NEU.EXC_CT.Ca2_signaling	1.90e-05	Nonsignificant	—	0.08	Other	68	17
649	EPI.skin_interfollicular_spinous.proliferative	1.76e-05	Nonsignificant	—	0.00	Other	0	0
650	EPI.renal_distal_tubule.immune_modulatory	1.56e-05	Nonsignificant	—	0.00	Other	0	0
651	ADIPO.inflammatory	1.48e-05	Nonsignificant	—	0.00	Other	0	0
652	HEP.acute_phase.hypoxia_lipid	1.47e-05	Nonsignificant	—	0.37	Other	0	0
653	HEP.acute_phase.inflammatory	1.45e-05	Nonsignificant	0.97	0.71	Other	382	649
654	NEU.EXC_NTNG1.nuclear_reg	1.29e-05	Nonsignificant	—	0.00	Other	0	0
655	T.CD8_Tcm.helper_like	1.28e-05	Nonsignificant	0.95	0.94	Other	81	159
656	T.gamma_delta.central_memory	1.20e-05	Nonsignificant	0.87	0.90	Other	460	919
657	B.germinal_center.LZ_survival	1.14e-05	Nonsignificant	—	0.00	Other	0	0
658	EPI.lung_multiciliated.stress	1.12e-05	Nonsignificant	—	0.00	Other	67	165
659	T.CD4_cytotoxic.NK_adapted	7.81e-06	Nonsignificant	0.34	1.16	Other	82	33
660	T.CD4_cytotoxic.terminal_effector	7.54e-06	Nonsignificant	0.34	1.09	Other	286	21
661	EPI.thymic_cortical.secretory_remodeling	6.93e-06	Nonsignificant	—	0.69	Other	4	1
662	MAC.alveolar.stress_metabolic	6.24e-06	Nonsignificant	0.46	1.12	Other	116	148
663	T.CD4_cytotoxic.baseline	6.21e-06	Nonsignificant	0.46	1.21	Other	0	0
664	T.CD4_Tcm.synapse_dynamics	6.20e-06	Nonsignificant	0.91	0.79	Other	15	10
665	DC.pDC.baseline	5.41e-06	Nonsignificant	0.92	0.72	Other	88	123
666	T.CD4_Tcm.retro_ZNF117	4.84e-06	Nonsignificant	0.91	0.77	Other	5	9
667	NK.adaptive_terminal_cytotoxic	4.45e-06	Nonsignificant	1.00	0.82	Other	485	802
668	EPI.pancreatic_ductal_progenitor.baseline	4.01e-06	Nonsignificant	0.99	0.55	Other	179	702
669	MAC.microglia_like.patrolling_adhesive	3.65e-06	Nonsignificant	—	0.00	Other	0	0
670	MAC.alveolar.capillary_interacting	3.09e-06	Nonsignificant	0.37	1.29	Other	113	181
671	NK.adaptive_adipose_stress	1.50e-06	Nonsignificant	1.00	0.76	Other	374	39
672	T.CD8_Tem.motility_primed	1.47e-06	Nonsignificant	0.70	0.97	Other	269	4
673	T.CD4_cytotoxic.activated	1.45e-06	Nonsignificant	0.50	1.07	Other	3	1
674	HEP.periportal_metabolic.xenobiotic_detox	1.41e-06	Nonsignificant	1.00	0.65	Other	1,440	139
675	HEP.periportal_metabolic.canonical_urea_cycle	1.12e-06	Nonsignificant	1.00	0.58	Other	1,464	269
676	EPI.pancreatic_ductal_progenitor.ciliated_transport	8.40e-07	Nonsignificant	—	0.00	Other	105	368
677	T.CD8_Tcm.gut_homing	4.58e-07	Nonsignificant	0.95	0.70	Other	380	112
678	T.CD4_cytotoxic.precursor	4.38e-07	Nonsignificant	0.50	1.11	Other	156	67
679	MAC.alveolar.biosynthetic_sterol_heme	4.29e-07	Nonsignificant	0.46	1.15	Other	347	40
680	MAC.alveolar.inflammatory	3.42e-07	Nonsignificant	0.70	0.92	Other	208	312
681	NK.adaptive_biosynthetic_primed	2.53e-07	Nonsignificant	1.00	0.60	Other	244	405
682	NEU.EXC_CT.Ca2_sensor	1.88e-07	Nonsignificant	—	0.00	Other	0	0
683	MAC.microglia_like.phagocytic_redox	1.12e-07	Nonsignificant	—	0.00	Other	0	0
684	MAC.alveolar.scavenging_endocytic	7.61e-08	Nonsignificant	—	0.00	Other	140	283
685	MAC.alveolar.lipid_autophagy	4.72e-08	Nonsignificant	—	0.00	Other	35	44
686	NEU.EXC_SYT2.nuclear_reg	1.34e-09	Nonsignificant	—	0.00	Other	0	0
687	EPI.thymic_cortical.baseline	4.67e-12	Nonsignificant	0.82	0.66	Other	185	386
688	EPI.thymic_cortical.Notch_interface	2.73e-12	Nonsignificant	—	0.00	Other	82	137

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

36 unique genes. Showing 1–36. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
VCAN	02-Medium	0.63	12.08	G2	C1	ASTRO.A1_reactive (L2), DC.cDC2.monocyte_like (L2), EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (L2), EPI.thymic_medullary.canonical_alarmin (L2), MONO.CD14.baseline (L2), MONO.CD16.inflammatory (L2), NEU.EXC_CT.remodeling (L2)	oligodendrocyte_precursor_cell (Tier: specific) OPC.oligodendrocyte_precursor_cell (Tier: specific) OPC.proliferative_immune_interact (Tier: relevant)	103 cells — complete matches	11	255
HAPLN1	02-Medium	0.56	11.62	G2	C1	—	—	42 cells — complete matches	6	44
ENSG00000293465	02-Medium	0.52	9.50	G2	C1	—	—	—	10	99
ENSG00000297123	02-Medium	0.48	8.51	G2	C1	—	—	—	7	55
ENSG00000248112	02-Medium	0.47	8.36	G2	C1	—	—	—	7	87
TGM5	02-Medium	0.43	4.70	G2	C2	—	—	15 cells — complete matches	0	0
ENSG00000261687	02-Medium	0.42	3.23	G1	C2	—	—	—	2	2
ZHX2	02-Medium	0.42	3.78	G1	C2	—	—	17 cells — complete matches	0	0
PDIA3	02-Medium	0.41	2.46	G2	C2	HEP.pericentral_lipoprotein.ApoB_coagulation (L2)	—	EPI.pancreatic_ductal_bicarbonate.junctional_remodel (L2)	7	8
ENSG00000285080	02-Medium	0.41	2.47	G1	C2	—	—	—	2	2
TP53BP1	02-Medium	0.40	4.36	G2	C2	—	—	7 cells — complete matches	3	4
SERF2	02-Medium	0.38	2.36	G1	C2	EC.arterial.metabolic (L2), EPI.cervical_suprabasal.secretory_vesicle (L2), EPI.colonic_tuft.homeostatic (L2)	—	5 cells — complete matches	11	22
CATSPER2P1.2	02-Medium	0.38	2.35	G2	C2	—	—	—	7	8
ENSG00000293372	02-Medium	0.38	5.66	G2	C2	—	—	—	32	56
TUBGCP4	02-Medium	0.37	4.27	G2	C2	—	EC.arterial.angiogenic_tip (Tier: specific)	10 cells — complete matches	2	3
ELL3	02-Medium	0.36	2.46	G1	C2	—	—	27 cells — complete matches	7	8
ENSG00000262560	02-Medium	0.35	2.42	G1	C2	—	—	—	10	12
WDR76	02-Medium	0.34	1.83	G2	C2	HEP.acute_phase.proliferative (L2)	EC.venous.remodeling_stalk (Tier: specific)	41 cells — complete matches	4	5
CATSPER2	02-Medium	0.34	3.02	G1	C2	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit (L2)	—	22 cells — complete matches	7	8
CKMT1A	02-Medium	0.33	2.39	G1	C2	—	EPI.bile_duct_cholangiocyte.secretory_mucin (Tier: relevant)	28 cells — complete matches	7	8
ENSG00000284772	02-Medium	0.33	3.60	G1	C2	—	—	—	4	5
ENSG00000271862	02-Medium	0.33	2.75	G2	C1	—	—	—	5	27
PPIP5K1	02-Medium	0.33	3.77	G1	C2	—	—	16 cells — complete matches	6	7
TMEM167A	02-Medium	0.33	2.17	G2	C1	—	—	—	3	14
HYPK	02-Medium	0.32	2.34	G1	C2	—	—	MG.expanding (L2)	7	8
MFAP1	02-Medium	0.32	2.02	G2	C2	—	—	—	7	8
ZSCAN29	02-Medium	0.32	4.17	G1	C2	—	—	11 cells — complete matches	1	2
FRMD5	02-Medium	0.31	1.03	G2	C2	—	GRNLSA.angiocrine_mechanosensory (Tier: relevant)	5 cells — complete matches	1	1
ERI1	02-Medium	0.30	5.93	G2	C2	—	—	25 cells — complete matches	61	289
SERINC4	02-Medium	0.30	2.21	G1	C2	—	EC.capillary.angiogenic_tip (Tier: specific)	14 cells — complete matches	7	9
EDIL3	02-Medium	0.28	1.28	G2	C1	FIB.interstitial.mesenchymal_regulator (L2), NEU.INH_VIP.excitatory_coupled (L2), OPC.premyelinating (L2)	EC.venous.remodeling_stalk (Tier: specific)	58 cells — complete matches	2	2
ENSG00000275601	02-Medium	0.28	3.36	G2	C2	—	—	—	3	4
MAP1A	02-Medium	0.27	4.35	G2	C2	—	—	38 cells — complete matches	1	2
CKMT1B	02-Medium	0.26	3.50	G2	C2	—	EPI.bile_duct_cholangiocyte.secretory_mucin (Tier: relevant)	36 cells — complete matches	1	2
MAPDA	02-Medium	0.26	4.77	G2	C2	—	—	—	0	0
LCMT2	02-Medium	0.24	4.63	G2	C2	—	—	23 cells — complete matches	0	0

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.