Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

GCST005367 · All tissues

Vitamin D levels: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Vitamin D

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	adipocyte	13.78	Significant	8.35e-03	1.46	Specific	33	111
2	microglia	10.45	Significant	4.28e-04	1.39	Specific	61	129
3	natural_killer_cell	10.14	Significant	3.30e-49	1.57	Specific	1,204	2,052
4	hepatocyte	8.32	Significant	1.59e-25	1.34	Specific	1,515	3,822
5	monocyte	5.42	Nominal	2.12e-33	1.27	Other	2,176	3,871
6	dendritic_cell	5.02	Nominal	0.02	1.17	Other	496	724
7	innate_lymphoid_cell_2	4.81	Nominal	1.00	1.01	Other	3	8
8	B_cell	4.55	Nominal	1.42e-07	1.17	Other	356	694
9	plasma_cell	3.04	Nominal	1.00	0.87	Other	17	24
10	mesothelial_cell	2.93	Nonsignificant	0.72	1.15	Other	6	36
11	macrophage	2.46	Nonsignificant	1.00	0.92	Other	813	1,732
12	T_cell	2.33	Nonsignificant	1.00	0.96	Other	470	959
13	astrocyte	1.99	Nonsignificant	1.00	1.03	Other	256	1,203
14	granulosa_cell	1.95	Nonsignificant	1.00	0.75	Other	293	670
15	thymocyte	1.80	Nonsignificant	1.00	0.84	Other	168	512
16	haematopoietic_progenitor_cell	1.57	Nonsignificant	1.00	0.76	Other	262	502
17	induced_pluripotent_stem_cell	1.37	Nonsignificant	1.00	0.98	Other	0	0
18	cardiomyocyte	1.31	Nonsignificant	1.00	0.81	Other	533	2,045
19	fibroblast	1.17	Nonsignificant	1.00	0.86	Other	184	826
20	granulocyte	0.84	Nonsignificant	1.00	0.62	Other	5	6
21	schwann_cell	0.48	Nonsignificant	1.00	0.60	Other	10	57
22	epithelial_cell	0.39	Nonsignificant	1.00	0.60	Other	24	47
23	muscle_stem_cell	0.21	Nonsignificant	1.00	0.54	Other	7	27
24	oligodendrocyte_precursor_cell	0.18	Nonsignificant	1.00	0.57	Other	461	1,454
25	chondrocyte	0.16	Nonsignificant	1.00	0.54	Other	548	1,069
26	adipose_stem_and_progenitor_cell	0.07	Nonsignificant	1.00	0.62	Other	327	954
27	smooth_muscle_cell	0.03	Nonsignificant	1.00	0.37	Other	27	139
28	pericyte	0.02	Nonsignificant	1.00	0.39	Other	128	517
29	endothelial_cell	0.02	Nonsignificant	1.00	0.34	Other	373	974
30	melanocyte	9.92e-03	Nonsignificant	1.00	0.32	Other	97	309
31	oligodendrocyte	1.23e-03	Nonsignificant	1.00	0.21	Other	385	1,507
32	neuron	8.64e-04	Nonsignificant	1.00	0.38	Other	330	1,328
33	skeletal_muscle_cell	2.94e-04	Nonsignificant	1.00	0.14	Other	944	2,600
34	platelet	1.25e-04	Nonsignificant	—	0.00	Other	85	104

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	ADIPO.adipocyte	13.78	Significant	—	—	Specific	20	62
2	B.germinal_center	13.47	Significant	1.33e-10	2.64	Specific	233	655
3	HEP.acute_phase	13.26	Significant	2.63e-14	1.85	Specific	1,441	3,641
4	MG.microglia	10.45	Significant	—	—	—	49	0
5	NK.natural_killer_cell	10.14	Significant	—	—	Specific	1,204	2,045
6	HEP.periportal_metabolic	9.39	Significant	4.55e-04	1.37	Specific	1,750	4,427
7	EPI.renal_proximal_tubule	8.91	Significant	2.40e-04	1.23	Specific	525	806
8	MONO.CD14	6.40	Significant	2.00e-50	2.27	Other	2,294	4,139
9	DC.cDC2	6.19	Significant	4.56e-03	1.51	Other	1,189	1,793
10	MAC.MDM	5.86	Significant	8.43e-08	1.71	Other	623	986
11	DC.cDC1	5.69	Significant	0.54	1.10	Relevant	55	112
12	T.CD8_Tem	5.42	Nominal	1.60e-49	2.28	Other	1,083	1,857
13	B.memory	5.23	Nominal	1.30e-06	1.76	Other	442	882
14	ILC2.innate_lymphoid_cell_2	4.81	Nominal	—	—	Other	2	0
15	PC.IgG_systemic	4.74	Nominal	0.02	1.52	Other	41	60
16	T.gamma_delta	4.48	Nominal	2.25e-11	1.88	Other	588	1,078
17	T.CD4_cytotoxic	3.98	Nominal	1.34e-05	1.71	Other	855	1,493
18	B.naive	3.90	Nominal	1.00	0.20	Other	307	595
19	MAC.kupffer	3.88	Nominal	1.73e-03	1.65	Other	189	530
20	HEP.canalicular_transport	3.80	Nominal	1.00	0.25	Other	1,290	3,434
21	T.CD8_naive	3.59	Nominal	8.35e-33	1.95	Other	317	708
22	MAC.resident_cardiac	3.23	Nominal	4.34e-03	1.35	Other	485	1,074
23	T.CD8_Tcm	3.09	Nominal	0.03	1.34	Other	460	926
24	T.CD8_Trm	2.99	Nonsignificant	4.39e-03	1.36	Other	211	346
25	MESO.mesothelial_cell	2.93	Nonsignificant	—	—	Other	2	18
26	MAC.microglia_like	2.92	Nonsignificant	1.00	0.89	Other	124	179
27	PC.IgA_muocsal	2.81	Nonsignificant	0.97	0.64	Other	18	31
28	T.CD8_transitional	2.76	Nonsignificant	0.01	1.23	Other	497	932
29	FIB.adventitial	2.42	Nonsignificant	9.00e-50	1.70	Other	268	1,447
30	B.age_associated	2.41	Nonsignificant	1.00	0.12	Other	207	350
31	MAC.alveolar	2.29	Nonsignificant	1.00	0.93	Other	1,432	3,122
32	DC.mig	2.19	Nonsignificant	—	0.00	Other	89	156
33	ASTRO.astrocyte	1.99	Nonsignificant	—	—	Other	228	1,111
34	GRNLSA.granulosa_cell	1.95	Nonsignificant	—	—	Other	257	0
35	T.MAIT	1.90	Nonsignificant	1.00	0.92	Other	469	855
36	THYMO.thymocyte	1.80	Nonsignificant	—	—	Other	163	495
37	T.CD4_Tem	1.72	Nonsignificant	1.00	0.66	Other	365	697
38	T.CD4_Tfh	1.63	Nonsignificant	1.00	0.65	Other	47	45
39	EPI.ileal_goblet	1.60	Nonsignificant	1.00	1.07	Other	181	432
40	HPC.haematopoietic_progenitor_cell	1.57	Nonsignificant	—	—	Other	211	370
41	MAC.resident_repair	1.56	Nonsignificant	1.00	0.55	Other	796	1,426
42	T.CD4_naive	1.52	Nonsignificant	1.00	0.50	Other	399	866
43	GRANU.neutrophil	1.50	Nonsignificant	0.02	1.78	Other	1,235	2,649
44	MAC.resident_iron	1.45	Nonsignificant	1.00	0.58	Other	16	21
45	EPI.colonic_enteroendocrine	1.42	Nonsignificant	—	1.17	Other	1	1
46	T.CD4_Th17	1.41	Nonsignificant	1.00	0.46	Other	421	794
47	EPI.skin_appendage_keratinocyte	1.40	Nonsignificant	0.03	1.21	Other	87	222
48	IPSC.induced_pluripotent_stem_cell	1.37	Nonsignificant	—	—	Other	0	0
49	T.CD4_Trm	1.32	Nonsignificant	1.00	0.31	Other	176	363
50	MAC.LAM	1.32	Nonsignificant	1.00	0.59	Other	914	2,064
51	CM.cardiomyocyte	1.31	Nonsignificant	—	—	Other	524	2,032
52	EPI.ileal_enterocyte_absorptive	1.08	Nonsignificant	1.00	1.06	Other	118	338
53	EPI.salivary_serous_acinar	0.94	Nonsignificant	0.08	1.09	Other	233	531
54	EPI.pancreatic_islet	0.92	Nonsignificant	0.44	1.18	Other	52	132
55	T.CD4_Tcm	0.85	Nonsignificant	1.00	0.11	Other	494	988
56	HEP.pericentral_lipoprotein	0.81	Nonsignificant	—	0.00	Other	0	0
57	EPI.ileal_bile_transport	0.66	Nonsignificant	1.00	1.02	Other	61	93
58	T.CD4_transitional	0.64	Nonsignificant	1.00	0.09	Other	48	110
59	EPI.tracheal_submucosal_gland	0.61	Nonsignificant	—	1.01	Other	0	0
60	EPI.skin_hair_follicle_companion	0.58	Nonsignificant	—	1.02	Other	8	12
61	SCHWN.schwann_cell	0.48	Nonsignificant	—	—	Other	7	33
62	GRANU.MAST	0.45	Nonsignificant	1.00	0.00	Other	5	6
63	EPI.ectocervical_granular	0.42	Nonsignificant	—	0.70	Other	11	23
64	EPI.ileal_enterocyte_crypt	0.42	Nonsignificant	1.00	0.92	Other	67	113
65	T.CD4_Th2	0.40	Nonsignificant	—	0.00	Other	1	2
66	EPI.gastric_foveolar	0.38	Nonsignificant	—	0.90	Other	0	0
67	EPI.cervical_suprabasal	0.38	Nonsignificant	—	0.86	Other	14	50
68	MAC.proliferating	0.35	Nonsignificant	1.00	0.42	Other	87	253
69	MONO.CD16	0.34	Nonsignificant	1.00	0.06	Other	1,304	1,835
70	EPI.renal_intercalated_cell_type_A	0.30	Nonsignificant	1.00	0.92	Other	67	142
71	FIB.skin_neurosecretory	0.28	Nonsignificant	—	0.10	Other	0	0
72	MUSC.muscle_stem_cell	0.21	Nonsignificant	—	—	Other	4	18
73	EPI.pancreatic_ductal_mucinous	0.20	Nonsignificant	1.00	0.96	Other	219	430
74	OPC.oligodendrocyte_precursor_cell	0.18	Nonsignificant	—	—	Other	413	1,269
75	FIB.skin_sheath	0.17	Nonsignificant	1.00	0.72	Other	49	118
76	CHOND.chondrocyte	0.16	Nonsignificant	—	—	Other	519	730
77	EPI.colonocyte	0.14	Nonsignificant	1.00	0.88	Other	294	815
78	EPI.renal_intercalated_cell_type_B	0.13	Nonsignificant	—	0.69	Other	6	7
79	DC.pDC	0.12	Nonsignificant	1.00	0.00	Other	496	1,028
80	EPI.lung_club_secretory	0.11	Nonsignificant	1.00	0.91	Other	5	14
81	T.CD4_Treg	0.11	Nonsignificant	1.00	0.41	Other	244	511
82	FIB.suburothelial	0.11	Nonsignificant	1.00	0.69	Other	122	432
83	FIB.perivascular_interface	0.10	Nonsignificant	1.00	0.70	Other	0	0
84	EPI.thymic_medullary	0.08	Nonsignificant	1.00	0.82	Other	26	133
85	FIB.barrier_secretory	0.07	Nonsignificant	1.00	0.78	Other	81	228
86	ASPC.adipose_stem_and_progenitor_cell	0.07	Nonsignificant	—	—	Other	324	930
87	FIB.hepatic_stellate_cell	0.07	Nonsignificant	—	0.00	Other	64	252
88	EPI.hepatic_ductular_cholangiocyte	0.06	Nonsignificant	1.00	0.95	Other	83	243
89	EPI.skin_hair_follicle_bulge	0.04	Nonsignificant	1.00	0.81	Other	51	178
90	EPI.salivary_duct_ion_transport	0.04	Nonsignificant	1.00	0.87	Other	5	11
91	FIB.lung_alveolar	0.04	Nonsignificant	—	0.00	Other	6	15
92	EPI.alveolar_type_2	0.04	Nonsignificant	1.00	0.83	Other	813	1,853
93	FIB.skin_tenogenic	0.04	Nonsignificant	—	0.00	Other	108	227
94	EPI.bile_duct_cholangiocyte	0.03	Nonsignificant	1.00	0.75	Other	37	60
95	SMC.smooth_muscle_cell	0.03	Nonsignificant	—	—	Other	20	101
96	EPI.esophageal_basal	0.03	Nonsignificant	1.00	0.78	Other	4	10
97	EC.arterial	0.03	Nonsignificant	0.28	1.06	Other	356	885
98	FIB.barrier_purinergic	0.02	Nonsignificant	—	0.00	Other	1	3
99	EC.lymphatic	0.02	Nonsignificant	0.04	1.23	Other	630	998
100	EPI.salivary_intercalated_defense	0.02	Nonsignificant	1.00	0.77	Other	81	161
101	FIB.skin_papillary	0.02	Nonsignificant	—	0.00	Other	0	0
102	FIB.interstitial	0.02	Nonsignificant	1.00	0.15	Other	288	940
103	EPI.tracheal_suprabasal	0.02	Nonsignificant	1.00	0.97	Other	29	56
104	PERI.pericyte	0.02	Nonsignificant	—	—	Other	117	0
105	EC.heart_remodeling	0.02	Nonsignificant	0.50	1.02	Other	569	1,594
106	EC.venous	0.02	Nonsignificant	0.50	1.02	Other	516	1,387
107	EPI.renal_distal_tubule	0.01	Nonsignificant	1.00	0.85	Other	133	361
108	EPI.colonic_tuft	0.01	Nonsignificant	—	0.41	Other	7	24
109	FIB.transitioning	0.01	Nonsignificant	1.00	0.49	Other	172	497
110	EC.liver_sinusoidal	0.01	Nonsignificant	0.50	1.06	Other	1,083	1,925
111	MEL.melanocyte	9.92e-03	Nonsignificant	—	—	Other	79	242
112	EPI.renal_immature_ureteric_bud	9.79e-03	Nonsignificant	1.00	0.70	Other	217	569
113	FIB.reticular	8.98e-03	Nonsignificant	1.00	0.34	Other	19	87
114	EC.capillary	8.36e-03	Nonsignificant	0.84	0.95	Other	514	1,635
115	EPI.salivary_duct_excretory	7.92e-03	Nonsignificant	1.00	0.64	Other	85	180
116	EPI.alveolar_type_1	6.26e-03	Nonsignificant	1.00	0.73	Other	26	101
117	EPI.pancreatic_ductal_perivascular	6.03e-03	Nonsignificant	1.00	0.74	Other	4	30
118	FIB.neurolectin_mucosa	4.46e-03	Nonsignificant	1.00	0.27	Other	133	394
119	EPI.renal_thick_ascending_limb	4.22e-03	Nonsignificant	1.00	0.67	Other	453	1,153
120	EPI.intrahepatic_cholangiocyte_transport	3.53e-03	Nonsignificant	—	0.20	Other	12	42
121	FIB.tracheal_subepithelial	3.51e-03	Nonsignificant	—	0.00	Other	0	0
122	EPI.skin_interfollicular_spinous	3.19e-03	Nonsignificant	1.00	0.87	Other	260	563
123	EPI.esophageal_suprabasal	2.48e-03	Nonsignificant	1.00	0.56	Other	158	404
124	EPI.renal_principal_cell	2.26e-03	Nonsignificant	1.00	0.52	Other	207	403
125	EPI.skin_keratinocyte_progenitor	1.88e-03	Nonsignificant	—	0.00	Other	0	3
126	EPI.extrahepatic_cholangiocyte	1.42e-03	Nonsignificant	—	0.00	Other	37	71
127	NEU.EXC_IT	1.40e-03	Nonsignificant	1.10e-14	1.14	Other	411	192
128	OLG.oligodendrocyte	1.23e-03	Nonsignificant	—	—	Other	384	1,397
129	EPI.pancreatic_acinar	1.07e-03	Nonsignificant	1.00	0.74	Other	429	1,475
130	EPI.pancreatic_ductal_bicarbonate	9.29e-04	Nonsignificant	1.00	0.45	Other	131	548
131	EPI.pancreatic_ductal_progenitor	9.23e-04	Nonsignificant	1.00	0.45	Other	234	873
132	EPI.salivary_mucous_acinar	7.88e-04	Nonsignificant	1.00	0.39	Other	639	1,189
133	EPI.skin_keratinocyte_basal	7.49e-04	Nonsignificant	—	0.00	Other	13	26
134	EPI.salivary_myoepithelial	7.38e-04	Nonsignificant	1.00	0.40	Other	191	714
135	NEU.INH_LAMP5	4.69e-04	Nonsignificant	0.63	1.04	Other	263	532
136	NEU.INH_VIP	4.29e-04	Nonsignificant	0.63	1.01	Other	241	366
137	SKM.type_2_fast	3.93e-04	Nonsignificant	0.09	1.19	Other	972	2,639
138	EPI.lung_multiciliated	3.75e-04	Nonsignificant	1.00	0.31	Other	16	49
139	EPI.intrahepatic_cholangiocyte_defense	1.86e-04	Nonsignificant	—	0.00	Other	8	13
140	EPI.skin_sebaceous_duct_luminal	1.72e-04	Nonsignificant	1.00	0.38	Other	100	249
141	SKM.type_1_slow	1.60e-04	Nonsignificant	0.92	0.72	Other	923	2,478
142	EPI.skin_sweat_duct_keratinocyte	1.56e-04	Nonsignificant	1.00	0.43	Other	146	301
143	NEU.EXC_CT	1.37e-04	Nonsignificant	0.63	0.99	Other	362	384
144	NEU.INH_PVALB	1.31e-04	Nonsignificant	0.63	0.96	Other	193	183
145	PLAT.platelet	1.25e-04	Nonsignificant	—	0.00	Other	38	53
146	NEU.EXC_SYT2	1.08e-04	Nonsignificant	—	0.57	Other	40	77
147	EPI.endocervical_secretory	8.81e-05	Nonsignificant	—	0.00	Other	0	0
148	EPI.skin_follicular_keratinizing	5.42e-05	Nonsignificant	1.00	0.24	Other	30	81
149	EPI.tracheal_basal	3.60e-05	Nonsignificant	1.00	0.17	Other	398	1,120
150	EPI.thymic_cortical	5.90e-07	Nonsignificant	1.00	0.10	Other	442	824
151	EPI.skin_keratinocyte_proliferating	3.10e-07	Nonsignificant	1.00	0.04	Other	47	76
152	NEU.EXC_NTNG1	2.98e-09	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	B.germinal_center.LZ_survival	17.56	Significant	—	1.47	—	0	0
2	NK.cytokine_tissue_activation	16.94	Significant	9.06e-05	2.67	Specific	267	450
3	ADIPO.thermogenic	16.63	Significant	—	0.94	—	0	0
4	HEP.periportal_metabolic.urea_onecarbon_secretory	16.57	Significant	2.06e-06	1.84	Specific	1,332	3,053
5	HEP.acute_phase.complement_metabolic	16.32	Significant	4.14e-03	2.02	Specific	1,423	3,464
6	HEP.acute_phase.complement_antiviral	14.40	Significant	0.60	1.25	Specific	377	751
7	B.germinal_center.DZ_M_phase	14.37	Significant	—	0.37	—	0	0
8	ADIPO.hypoxia_remodelling	13.27	Significant	—	0.00	Relevant	29	105
9	ADIPO.inflammatory	13.26	Significant	—	0.00	Relevant	0	0
10	B.germinal_center.LZ_memory_precursor	12.81	Significant	—	0.00	Relevant	0	0
11	MAC.kupffer.monocyte_like	12.67	Significant	—	1.29	Relevant	0	0
12	HEP.acute_phase.baseline	12.62	Significant	1.00	0.73	—	946	19
13	ADIPO.immature	12.40	Significant	—	0.00	—	24	40
14	B.germinal_center.DZ_S_phase	12.24	Significant	—	0.00	—	0	0
15	NK.cytokine_lung_immediate_early	12.23	Significant	7.31e-03	2.17	—	424	274
16	B.germinal_center.LZ_selection	12.08	Significant	—	0.00	—	0	0
17	HEP.acute_phase.stress_secretory	12.01	Significant	0.60	1.15	—	26	3
18	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	11.67	Significant	—	1.50	Other	39	82
19	NK.cytokine_axis_baseline	11.62	Significant	1.66e-10	2.60	—	1,172	116
20	MG.baseline	11.28	Significant	0.21	1.57	—	16	5
21	NK.cytokine_vascular_patrolling	10.99	Significant	0.25	1.49	—	863	94
22	PC.IgG_systemic.metabolic	10.88	Significant	1.98e-04	1.75	Specific	46	63
23	NK.cytokine_biosynthetic_primed	10.87	Significant	0.25	1.54	—	360	21
24	HEP.periportal_metabolic.xenobiotic_detox	10.55	Significant	0.76	1.03	—	1,440	139
25	NK.cytokine_quiescent	10.40	Significant	1.00	1.02	Specific	623	1,062
26	MG.phagocytic_APC	10.36	Significant	0.78	0.69	—	25	8
27	NK.cytokine_repair_primed	10.00	Significant	0.41	1.37	—	266	11
28	MAC.kupffer.fibrogenic	9.82	Significant	—	0.87	Relevant	0	0
29	FIB.adventitial.activated_remodelling	9.81	Significant	—	1.43	Relevant	141	319
30	EPI.renal_proximal_tubule.detox_antioxidant	9.72	Significant	5.36e-03	2.63	—	394	77
31	NK.adaptive_adipose_stress	9.66	Significant	1.00	0.54	—	374	39
32	NK.adaptive_immature_precursor	9.35	Significant	1.00	0.68	—	358	111
33	HEP.periportal_metabolic.stress_chaperone	9.35	Significant	—	0.01	Relevant	66	128
34	NK.adaptive_HLAE_tuned	9.35	Significant	1.00	0.47	—	1,124	189
35	IPSC.canonical_pluripotent	9.20	Significant	4.73e-14	1.35	Relevant	0	0
36	HEP.periportal_metabolic.canonical_urea_cycle	9.13	Significant	0.76	1.09	—	1,464	269
37	NK.adaptive_axis_baseline	9.13	Significant	1.00	0.43	—	1,008	153
38	HEP.periportal_metabolic.apolipoprotein_secretory	9.02	Significant	0.76	1.04	Relevant	43	110
39	NK.adaptive_biosynthetic_primed	8.61	Significant	1.00	0.37	Relevant	244	405
40	DC.cDC1.homeostatic_inhibitory	8.46	Significant	—	1.21	Relevant	0	0
41	DC.cDC2.migratory	8.22	Significant	0.51	1.29	Relevant	185	39
42	NK.adaptive_classII_inhibitory	8.05	Significant	1.00	0.38	—	880	154
43	HEP.acute_phase.proliferative	8.02	Significant	—	0.00	Relevant	4	6
44	HEP.acute_phase.hypoxia_lipid	7.97	Significant	—	0.00	Relevant	0	0
45	HEP.acute_phase.inflammatory	7.95	Significant	1.00	0.07	Relevant	382	649
46	MG.expanding	7.95	Significant	0.63	1.07	—	2	1
47	MAC.MDM.inflammatory_phagocytic	7.91	Significant	5.93e-03	1.86	Specific	199	52
48	EPI.renal_proximal_tubule.onecarbon_peroxisome	7.80	Significant	1.00	0.00	Relevant	58	89
49	NK.cytokine_tissue_resident	7.59	Significant	1.00	0.42	—	74	82
50	MONO.CD14.baseline	7.55	Significant	1.23e-06	1.43	Specific	2,268	76
51	ILC2.quiescent	7.50	Significant	—	0.80	Relevant	0	0
52	NK.adaptive_terminal_cytotoxic	7.42	Significant	1.00	0.18	Specific	485	802
53	DC.cDC2.adhesion_signaling	7.31	Significant	0.52	1.22	Relevant	35	9
54	DC.cDC2.antiviral	7.22	Significant	0.67	1.04	Relevant	100	37
55	NK.immature_bridge	7.20	Significant	1.00	0.30	—	117	122
56	MAC.MDM.APC_dendritic	7.05	Significant	0.30	1.34	Relevant	48	15
57	T.CD8_Tem.TEMRA	7.02	Significant	7.01e-04	2.09	Specific	920	1,088
58	T.CD4_naive.activated_stress	7.02	Significant	2.37e-10	2.85	Specific	339	429
59	B.memory.preactivated	6.86	Significant	0.03	1.79	Specific	173	174
60	B.memory.activated	6.72	Significant	5.38e-03	1.98	Specific	105	29
61	MONO.CD14.cord_tolerance	6.41	Significant	0.95	1.07	Relevant	864	753
62	MONO.CD14.remodeling	6.40	Significant	0.95	1.02	Other	2,373	295
63	DC.cDC2.monocyte_like	6.38	Significant	0.51	1.31	Other	1,285	791
64	T.CD8_Tem.early_helper_like	6.13	Significant	0.03	1.73	Specific	445	755
65	DC.cDC1.cross_presenting	5.86	Significant	—	0.17	—	0	0
66	HEP.periportal_metabolic.acute_phase_barrier	5.77	Significant	1.00	0.64	Other	533	138
67	HEP.periportal_metabolic.stress_checkpoint	5.68	Significant	1.00	0.59	Other	234	786
68	DC.cDC2.tolerogenic_regulatory	5.66	Significant	0.94	0.76	Other	44	4
69	ASTRO.homeostatic	5.45	Nominal	0.02	1.32	Other	200	431
70	T.CD8_Tem.signaling_turnover	5.44	Nominal	0.56	1.11	Other	425	683
71	HEP.canalicular_transport.inflammatory	5.43	Nominal	3.76e-08	2.12	Other	1,335	194
72	T.CD8_Tcm.NK_like	5.42	Nominal	0.09	1.58	Other	334	581
73	T.CD8_Tem.motility_primed	5.33	Nominal	0.56	1.19	Other	269	4
74	T.CD4_cytotoxic.NK_adapted	5.25	Nominal	0.25	1.59	Other	82	33
75	DC.cDC1.activated	5.24	Nominal	—	0.00	Other	0	0
76	DC.cDC1.proliferative	5.19	Nominal	—	0.00	Other	0	0
77	T.gamma_delta.cytotoxic_effector	5.13	Nominal	0.04	1.86	Other	349	109
78	T.CD8_Tem.stress_adapted	5.06	Nominal	1.00	0.52	Other	607	520
79	HPC.CLP_B_primed	5.05	Nominal	—	1.52	Other	0	0
80	B.memory.baseline	4.87	Nominal	0.99	0.73	Other	472	99
81	B.naive.restrained	4.78	Nominal	1.15e-03	1.84	Other	183	353
82	T.CD8_Tcm.gut_homing	4.76	Nominal	0.09	1.53	Other	380	112
83	T.CD4_cytotoxic.activated	4.61	Nominal	0.25	1.43	Other	3	1
84	T.CD8_Trm.dendritic_recruiter	4.55	Nominal	0.03	1.93	Other	47	85
85	T.CD8_transitional.effector_primed	4.40	Nominal	8.90e-10	2.24	Other	435	151
86	T.gamma_delta.early_effector	4.35	Nominal	0.93	0.88	Other	89	0
87	HPC.MPP_activated	4.34	Nominal	—	1.12	Other	0	0
88	MAC.microglia_like.phagocytic_redox	4.34	Nominal	—	0.52	Other	0	0
89	HPC.GMP_granulocytic	4.33	Nominal	—	0.50	Other	3	3
90	B.memory.migratory	4.28	Nominal	0.99	0.40	Other	123	208
91	B.memory.pDC_imprint	4.28	Nominal	0.99	0.51	Other	157	103
92	B.naive.proteostasis	4.21	Nominal	0.34	1.42	Other	49	69
93	T.CD8_naive.lipid_synthesis	4.21	Nominal	0.35	1.61	Other	6	4
94	T.CD8_Tem.baseline	4.19	Nominal	1.00	0.12	Other	458	356
95	ILC2.activated	4.18	Nominal	—	0.00	Other	0	0
96	ASTRO.stress_mito	4.18	Nominal	0.71	1.15	Other	47	110
97	MAC.kupffer.inflammatory	4.08	Nominal	—	0.00	Other	7	4
98	B.naive.activated	4.05	Nominal	0.99	1.03	Other	77	127
99	MAC.MDM.LAM_like	4.02	Nominal	1.00	0.57	Other	12	14
100	EPI.colonic_enteroendocrine.progenitor	4.02	Nominal	—	0.97	Other	0	0
101	ASPC.mesothelial_like	3.99	Nominal	0.26	1.51	Other	143	486
102	T.gamma_delta.central_memory	3.97	Nominal	0.99	0.11	Other	460	919
103	MESO.baseline	3.93	Nominal	0.02	1.50	Other	0	6
104	PC.IgA_muocsal.plasmablast	3.91	Nominal	0.36	1.29	Other	5	4
105	T.CD8_Tcm.baseline	3.91	Nominal	0.33	1.24	Other	90	89
106	HEP.canalicular_transport.baseline	3.88	Nominal	1.00	0.95	Other	199	477
107	T.CD8_naive.vesicle_secretory	3.86	Nominal	0.43	1.23	Other	42	0
108	B.naive.remodeling	3.84	Nominal	0.99	0.99	Other	135	230
109	T.CD8_naive.innate_like	3.82	Nominal	0.35	1.60	Other	10	1
110	GRNLSA.EMT_insulin_signaling	3.75	Nominal	0.14	1.67	Other	47	84
111	GRNLSA.angiocrine_mechanosensory	3.73	Nominal	—	1.14	Other	0	0
112	MAC.resident_cardiac.inflammatory_reparative	3.72	Nominal	0.26	1.58	Other	31	96
113	B.naive.purinergic	3.71	Nominal	0.99	0.75	Other	384	820
114	T.CD8_naive.nfkb_related	3.69	Nominal	0.43	1.23	Other	1	0
115	T.CD8_naive.mito_proteostasis	3.68	Nominal	0.35	1.43	Other	428	100
116	MAC.MDM.complement_resolving	3.67	Nominal	1.00	0.31	Other	440	860
117	T.CD8_naive.effector_transition	3.66	Nominal	0.35	1.40	Other	35	62
118	MAC.resident_repair.stress_iron	3.62	Nominal	0.25	1.60	Other	48	97
119	T.CD8_naive.splicing_enriched	3.61	Nominal	0.94	0.79	Other	120	16
120	T.CD4_cytotoxic.terminal_effector	3.59	Nominal	0.98	0.34	Other	286	21
121	B.naive.antigen_presenting_ready	3.56	Nominal	0.99	0.57	Other	48	73
122	B.naive.baseline	3.55	Nominal	0.99	0.72	Other	10	13
123	B.naive.receptor_recycle	3.55	Nominal	0.99	0.64	Other	51	0
124	MESO.activated_stress	3.53	Nominal	—	0.42	Other	0	0
125	T.CD4_Tfh.canonical_GC_helper	3.49	Nominal	3.94e-03	1.79	Other	1	2
126	T.CD8_naive.baseline	3.47	Nominal	0.95	0.48	Other	142	2
127	T.CD4_cytotoxic.precursor	3.46	Nominal	0.25	1.51	Other	156	67
128	DC.cDC2.pro_inflammatory	3.44	Nominal	0.98	0.30	Other	3	5
129	HEP.canalicular_transport.pericentral_like_hypoxia	3.38	Nominal	1.00	0.82	Other	326	8
130	T.CD8_naive.cytokine_dampened	3.35	Nominal	0.94	0.66	Other	71	4
131	FIB.adventitial.mito_secretory	3.32	Nominal	0.25	1.44	Other	21	7
132	DC.cDC1.baseline	3.25	Nominal	—	0.00	Other	0	0
133	MAC.resident_cardiac.phagocytic_homeostasis	3.25	Nominal	0.44	1.04	Other	564	1,221
134	HEP.canalicular_transport.secretory_ERAD_UPR	3.23	Nominal	1.00	0.63	Other	232	28
135	T.CD8_Trm.homeostatic	3.13	Nominal	0.63	1.13	Other	42	5
136	PC.IgA_muocsal.activated	3.12	Nominal	0.24	1.30	Other	17	8
137	FIB.adventitial.baseline	3.01	Nominal	0.13	1.42	Other	157	278
138	MAC.alveolar.inflammatory	2.97	Nonsignificant	6.22e-03	2.23	Other	208	312
139	B.naive.metabolic	2.94	Nonsignificant	0.99	0.43	Other	50	79
140	T.CD8_Trm.cytotoxic	2.93	Nonsignificant	0.63	1.08	Other	165	85
141	MAC.alveolar.lipid_autophagy	2.89	Nonsignificant	—	0.57	Other	35	44
142	T.CD8_Trm.inflammatory	2.88	Nonsignificant	0.89	0.84	Other	124	176
143	MAC.resident_cardiac.antigen_presenting	2.88	Nonsignificant	0.28	1.33	Other	52	27
144	HEP.canalicular_transport.injury_stress	2.87	Nonsignificant	1.00	0.31	Other	289	24
145	HEP.canalicular_transport.sterol_lipid_biosynthesis	2.83	Nonsignificant	—	0.00	Other	10	20
146	PC.IgA_muocsal.migratory	2.80	Nonsignificant	0.51	1.06	Other	4	1
147	PC.IgG_systemic.interacting	2.78	Nonsignificant	1.00	0.78	Other	0	0
148	T.CD8_Tcm.effector_bias	2.78	Nonsignificant	0.76	0.93	Other	199	329
149	T.CD8_transitional.early	2.76	Nonsignificant	0.26	1.22	Other	327	55
150	FIB.adventitial.inflammatory_activated	2.75	Nonsignificant	0.08	1.58	Other	100	473
151	MESO.secretory_structural	2.74	Nonsignificant	—	0.11	Other	0	0
152	GRNLSA.p53_damage	2.71	Nonsignificant	—	0.58	Other	13	10
153	ASPC.signal_integrator	2.70	Nonsignificant	—	2.47	Other	0	0
154	MAC.microglia_like.patrolling_adhesive	2.70	Nonsignificant	—	0.17	Other	0	0
155	THYMO.DP_early	2.69	Nonsignificant	1.58e-08	2.32	Other	326	313
156	B.age_associated.migratory	2.64	Nonsignificant	0.29	1.29	Other	2	2
157	B.age_associated.naive_transitional	2.62	Nonsignificant	—	0.33	Other	0	0
158	MAC.alveolar.scavenging_endocytic	2.56	Nonsignificant	—	0.21	Other	140	283
159	GRNLSA.lipid_hypoxia	2.54	Nonsignificant	0.54	1.29	Other	28	0
160	T.CD4_cytotoxic.baseline	2.46	Nonsignificant	0.98	0.17	Other	0	0
161	THYMO.SP_CD8_transitional	2.46	Nonsignificant	0.21	1.54	Other	32	75
162	MONO.CD14.platelet_bound	2.43	Nonsignificant	1.00	0.63	Other	964	176
163	MESO.activated_migratory	2.43	Nonsignificant	—	0.18	Other	0	0
164	T.CD4_Tem.cytotoxic_effector	2.41	Nonsignificant	0.03	1.58	Other	225	398
165	MAC.microglia_like.inflammatory_chemokine	2.38	Nonsignificant	—	0.00	Other	20	32
166	ILC2.migratory	2.37	Nonsignificant	—	0.00	Other	0	0
167	FIB.adventitial.mechano_chemo_sensing	2.35	Nonsignificant	0.77	0.95	Other	135	524
168	ASTRO.immature_lipid	2.35	Nonsignificant	1.00	0.88	Other	23	113
169	GRNLSA.cholesterol_mevalonate	2.34	Nonsignificant	0.67	1.16	Other	9	4
170	T.CD8_transitional.Trm_primed	2.28	Nonsignificant	1.00	0.60	Other	108	15
171	THYMO.SP_CD4_naive	2.27	Nonsignificant	0.22	1.39	Other	65	75
172	EPI.pancreatic_islet.alpha	2.23	Nonsignificant	—	0.94	Other	152	330
173	ASTRO.A2_reactive	2.21	Nonsignificant	1.00	0.86	Other	10	37
174	T.MAIT.cytotoxic	2.20	Nonsignificant	0.65	1.20	Other	52	15
175	PC.IgA_muocsal.baseline	2.19	Nonsignificant	0.99	0.50	Other	3	5
176	DC.mig.baseline	2.19	Nonsignificant	—	0.00	Other	1	0
177	GRNLSA.stress_metabolic	2.17	Nonsignificant	—	0.04	Other	1	2
178	T.CD4_Th17.cytotoxic	2.16	Nonsignificant	0.10	1.64	Other	332	123
179	MAC.LAM.inflammatory_APC	2.13	Nonsignificant	5.09e-06	1.45	Other	872	165
180	CM.inflammatory	2.13	Nonsignificant	—	1.60	Other	0	0
181	ASTRO.synaptic_interaction	2.08	Nonsignificant	1.00	0.88	Other	76	334
182	MAC.resident_iron.APC_iron_sensing	2.06	Nonsignificant	0.23	1.38	Other	211	114
183	THYMO.DN_preTCR	2.03	Nonsignificant	0.22	1.35	Other	41	71
184	T.CD4_Tem.long_term_memory	2.02	Nonsignificant	0.12	1.37	Other	314	587
185	B.age_associated.activated	2.01	Nonsignificant	—	0.00	Other	18	22
186	T.MAIT.MAPK_brake	1.98	Nonsignificant	0.65	1.41	Other	44	66
187	FIB.adventitial.adhesion_lipid	1.98	Nonsignificant	0.19	1.44	Other	58	209
188	GRANU.neutrophil.tissue_patrolling	1.97	Nonsignificant	—	0.52	Other	0	0
189	FIB.adventitial.complement_angiocrine	1.93	Nonsignificant	1.00	0.54	Other	153	684
190	T.MAIT.migratory	1.93	Nonsignificant	0.65	1.21	Other	10	1
191	T.CD4_naive.proteostasis_mitoprot	1.92	Nonsignificant	0.47	1.52	Other	15	37
192	MAC.resident_repair.antigen_presenting	1.89	Nonsignificant	0.31	1.31	Other	244	113
193	MAC.alveolar.biosynthetic_sterol_heme	1.88	Nonsignificant	0.99	0.48	Other	347	40
194	T.CD4_Trm.cytotoxic_effector	1.87	Nonsignificant	0.06	1.58	Other	118	77
195	THYMO.CD8aa_IELp	1.84	Nonsignificant	—	2.69e-03	Other	1	7
196	T.CD4_naive.proteostasis	1.83	Nonsignificant	0.47	1.43	Other	14	9
197	EPI.ileal_goblet.baseline	1.82	Nonsignificant	0.39	1.46	Other	16	2
198	PC.IgG_systemic.stress	1.82	Nonsignificant	—	0.00	Other	1	5
199	T.MAIT.vesicle	1.81	Nonsignificant	0.86	0.84	Other	37	65
200	T.MAIT.quiescent	1.81	Nonsignificant	0.86	0.57	Other	100	5
201	THYMO.DP_early_stress	1.79	Nonsignificant	—	0.09	Other	0	0
202	HEP.canalicular_transport.ductular_like_transition	1.77	Nonsignificant	1.00	0.00	Other	400	87
203	CM.mechano_activated	1.76	Nonsignificant	8.66e-03	2.19	Other	205	134
204	T.MAIT.early_activation	1.75	Nonsignificant	0.86	0.56	Other	57	4
205	T.CD8_Trm.muscosal_Tc17	1.75	Nonsignificant	1.00	0.00	Other	19	38
206	MAC.alveolar.capillary_interacting	1.75	Nonsignificant	0.99	0.22	Other	113	181
207	T.CD4_Tcm.regulatory_poised	1.71	Nonsignificant	0.07	1.60	Other	2	3
208	EPI.ileal_goblet.stress_metallothionein	1.67	Nonsignificant	—	0.17	Other	4	11
209	T.MAIT.stress	1.67	Nonsignificant	—	0.00	Other	0	0
210	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.67	Nonsignificant	—	0.13	Other	19	54
211	T.CD4_naive.neddylation	1.65	Nonsignificant	0.65	1.23	Other	104	222
212	T.CD4_naive.resist_bystander	1.62	Nonsignificant	0.82	1.01	Other	40	25
213	MONO.CD14.inflammatory	1.61	Nonsignificant	1.00	0.25	Other	92	134
214	MAC.resident_repair.chemokine_angiocrine	1.60	Nonsignificant	0.99	0.95	Other	87	138
215	T.CD4_naive.survival_neddylation	1.58	Nonsignificant	0.78	1.15	Other	26	38
216	FIB.adventitial.PI16_matrix	1.58	Nonsignificant	1.00	0.16	Other	70	90
217	CM.translation_boost_RPS	1.56	Nonsignificant	0.74	1.21	Other	69	16
218	T.CD4_Tfh.precursor_migratory	1.54	Nonsignificant	0.86	1.06	Other	72	27
219	DC.cDC2.lipid_metabolic	1.54	Nonsignificant	—	0.00	Other	0	0
220	MAC.alveolar.stress_metabolic	1.52	Nonsignificant	0.99	0.12	Other	116	148
221	T.CD4_naive.survival	1.51	Nonsignificant	0.82	0.95	Other	12	17
222	T.CD4_naive.purinergic	1.51	Nonsignificant	0.82	0.98	Other	49	1
223	T.CD4_naive.neddylation_mitoprot	1.48	Nonsignificant	0.78	1.14	Other	93	56
224	MAC.resident_iron.heme_recycling	1.48	Nonsignificant	—	0.22	Other	30	37
225	DC.cDC2.proliferative	1.47	Nonsignificant	—	0.00	Other	39	71
226	T.CD4_Tcm.effector_like	1.47	Nonsignificant	0.01	1.69	Other	293	533
227	MESO.antiviral	1.45	Nonsignificant	—	0.00	Other	3	8
228	T.CD4_naive.survival_mitoprot	1.44	Nonsignificant	0.82	0.89	Other	13	7
229	T.CD4_naive.mature	1.44	Nonsignificant	0.93	0.84	Other	211	100
230	GRANU.neutrophil.antiviral_endotoxin	1.43	Nonsignificant	—	0.38	Other	0	0
231	EPI.ileal_goblet.inflammatory_mucin	1.41	Nonsignificant	0.90	0.31	Other	6	9
232	T.CD8_transitional.APC_like	1.40	Nonsignificant	1.00	0.06	Other	205	62
233	T.CD4_naive.homeostatic	1.40	Nonsignificant	1.00	0.65	Other	215	108
234	T.CD4_Trm.central_like	1.39	Nonsignificant	0.96	1.02	Other	38	31
235	THYMO.SP_CD8_naive	1.39	Nonsignificant	1.00	0.58	Other	297	177
236	T.CD4_Tem.inflammatory	1.38	Nonsignificant	1.00	0.41	Other	28	6
237	EPI.ileal_enterocyte_absorptive.brush_border	1.37	Nonsignificant	3.94e-05	2.61	Other	580	1,717
238	CM.baseline	1.37	Nonsignificant	0.10	1.60	Other	393	0
239	T.CD4_naive.gut_prone	1.37	Nonsignificant	0.82	0.89	Other	35	70
240	T.CD4_Th17.baseline	1.37	Nonsignificant	0.94	0.91	Other	51	5
241	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.35	Nonsignificant	—	0.97	Other	0	0
242	PC.IgG_systemic.secretory	1.34	Nonsignificant	1.00	0.06	Other	0	0
243	T.CD4_naive.mature_mitoprot	1.33	Nonsignificant	1.00	0.44	Other	212	476
244	T.CD4_Trm.helper_like	1.32	Nonsignificant	0.96	0.90	Other	84	147
245	CM.osmoprotection	1.31	Nonsignificant	0.98	0.86	Other	34	57
246	CM.contractile_oxphos	1.31	Nonsignificant	0.41	1.50	Other	6	19
247	CM.mito_proteostasis	1.27	Nonsignificant	0.98	0.75	Other	329	29
248	CM.anti_inflammatory	1.21	Nonsignificant	0.98	0.47	Other	424	1,503
249	T.CD4_Tcm.crosstalk_myeloid	1.21	Nonsignificant	0.59	1.28	Other	5	4
250	CM.oxidative_phospho	1.20	Nonsignificant	0.98	0.79	Other	266	792
251	CM.sarcomere_actin_interface	1.19	Nonsignificant	0.98	0.43	Other	450	78
252	GRANU.neutrophil.primed_degranulation	1.17	Nonsignificant	—	0.00	Other	0	0
253	EPI.ileal_goblet.immature	1.15	Nonsignificant	—	0.00	Other	0	0
254	CM.translation_boost_RPL	1.15	Nonsignificant	0.98	0.38	Other	129	1
255	T.CD4_Trm.stress_adaptive	1.15	Nonsignificant	0.96	0.80	Other	8	22
256	T.CD4_Trm.baseline	1.11	Nonsignificant	0.96	0.67	Other	31	21
257	T.CD4_Tcm.migratory_cilium	1.10	Nonsignificant	0.59	1.21	Other	5	10
258	GRNLSA.chemokine_mechanosensory	1.09	Nonsignificant	1.00	0.33	Other	1	0
259	GRNLSA.secretory_remodeling	1.08	Nonsignificant	1.00	0.23	Other	90	25
260	T.CD8_Tcm.helper_like	1.07	Nonsignificant	1.00	0.00	Other	81	159
261	MAC.kupffer.metabolic	1.07	Nonsignificant	—	0.00	Other	25	36
262	MAC.resident_repair.lipid_phagocytic	1.05	Nonsignificant	0.99	0.56	Other	228	604
263	HPC.LMPP	1.03	Nonsignificant	0.92	0.93	Other	65	31
264	IPSC.stress	1.02	Nonsignificant	1.00	0.93	Other	0	0
265	T.CD4_Tcm.retro_ZNF117	0.99	Nonsignificant	1.00	0.98	Other	5	9
266	THYMO.SP_CD8_naive_stress	0.99	Nonsignificant	1.00	0.20	Other	1	1
267	T.CD4_Tcm.synapse_dynamics	0.97	Nonsignificant	0.59	1.28	Other	15	10
268	T.CD4_Trm.activated	0.97	Nonsignificant	0.96	0.52	Other	32	26
269	EPI.ectocervical_granular.immune_interact	0.96	Nonsignificant	—	1.15	Other	0	0
270	EPI.salivary_serous_acinar.secretory_active	0.96	Nonsignificant	0.30	1.38	Other	242	69
271	HEP.periportal_metabolic.inflammatory_activated	0.96	Nonsignificant	1.00	0.15	Other	712	1,610
272	T.CD4_Tcm.DC_interact	0.95	Nonsignificant	1.00	0.98	Other	72	32
273	T.CD4_Tfh.effector_migratory	0.94	Nonsignificant	0.96	0.50	Other	122	57
274	EPI.colonocyte.distal_absorptive	0.92	Nonsignificant	—	1.62	Other	0	0
275	ASTRO.hypoxia_angiogenic	0.91	Nonsignificant	1.00	0.75	Other	5	18
276	HPC.GMP_inflammatory	0.91	Nonsignificant	0.92	0.82	Other	20	10
277	MAC.resident_iron.heme_catabolism	0.87	Nonsignificant	0.91	0.71	Other	30	51
278	MONO.CD14.APC_like	0.87	Nonsignificant	1.00	0.07	Other	1,686	2,493
279	MAC.resident_repair.ECM_stromal_crosstalk	0.85	Nonsignificant	0.99	0.32	Other	95	158
280	T.CD4_transitional.primed_helper_effector	0.85	Nonsignificant	0.09	1.52	Other	19	43
281	MAC.kupffer.tolerogenic	0.85	Nonsignificant	—	0.17	Other	45	49
282	EPI.tracheal_submucosal_gland.ductal_luminal	0.84	Nonsignificant	—	0.73	Other	0	0
283	T.CD4_Tfh.suppression_exhaustion	0.84	Nonsignificant	0.96	0.45	Other	0	2
284	EPI.salivary_serous_acinar.quiescent	0.83	Nonsignificant	0.80	0.74	Other	178	493
285	GRNLSA.proliferative_migratory	0.82	Nonsignificant	1.00	0.18	Other	248	292
286	HEP.pericentral_lipoprotein.ApoB_coagulation	0.81	Nonsignificant	—	0.67	Other	0	0
287	HEP.pericentral_lipoprotein.UPR_redox	0.80	Nonsignificant	—	0.00	Other	0	0
288	HPC.MEP	0.79	Nonsignificant	0.92	0.68	Other	599	1,195
289	EPI.ileal_enterocyte_absorptive.villus_tip	0.79	Nonsignificant	1.00	0.00	Other	4	3
290	MAC.proliferating.stress	0.79	Nonsignificant	—	0.42	Other	87	136
291	T.CD4_Tcm.secretory	0.78	Nonsignificant	1.00	0.93	Other	20	11
292	T.CD4_Tcm.RNA_control	0.76	Nonsignificant	1.00	0.71	Other	96	4
293	MAC.LAM.antimicrobial	0.76	Nonsignificant	1.00	0.79	Other	389	93
294	T.CD4_Tem.transitional_CM	0.75	Nonsignificant	1.00	0.00	Other	31	20
295	IPSC.axial_identity_primed	0.72	Nonsignificant	1.00	0.85	Other	0	0
296	EPI.ileal_bile_transport.detox_transcytosis	0.72	Nonsignificant	—	0.16	Other	0	1
297	T.CD4_Tcm.stress	0.72	Nonsignificant	1.00	0.62	Other	5	11
298	T.CD4_transitional.baseline	0.71	Nonsignificant	0.25	1.27	Other	59	97
299	EPI.ectocervical_granular.secretory_apocrine	0.71	Nonsignificant	—	0.32	Other	0	0
300	IPSC.mesendo_primed	0.71	Nonsignificant	1.00	0.87	Other	0	0
301	T.CD4_Th17.migratory	0.70	Nonsignificant	1.00	0.20	Other	13	23
302	T.CD4_Tcm.imprinted_splicing	0.70	Nonsignificant	1.00	0.76	Other	6	17
303	T.CD4_Tcm.tissue_homing	0.68	Nonsignificant	1.00	0.70	Other	78	46
304	MAC.resident_iron.stress_tolerogenic	0.68	Nonsignificant	—	0.00	Other	0	0
305	SCHWN.axon_contact_cardiac	0.67	Nonsignificant	0.10	1.43	Other	18	63
306	T.CD4_transitional.primed_cytotoxic	0.67	Nonsignificant	0.56	1.10	Other	28	30
307	T.CD4_Trm.metal_stress	0.65	Nonsignificant	0.96	0.46	Other	34	58
308	T.CD8_transitional.stress	0.65	Nonsignificant	—	0.00	Other	24	34
309	EC.lymphatic.valve	0.64	Nonsignificant	—	2.18	Other	0	0
310	EPI.ileal_bile_transport.absorptive_xenobiotic	0.64	Nonsignificant	0.33	1.21	Other	11	12
311	MAC.resident_iron.redox_metabolic	0.62	Nonsignificant	0.91	0.55	Other	4	4
312	T.CD4_Tcm.Th2_like	0.62	Nonsignificant	1.00	0.77	Other	23	55
313	EPI.ileal_enterocyte_crypt.secretory_precursor	0.62	Nonsignificant	—	0.99	Other	0	0
314	EPI.colonocyte.ionocyte_BEST4	0.61	Nonsignificant	0.73	1.25	Other	103	188
315	IPSC.stromal_primed	0.60	Nonsignificant	1.00	0.78	Other	0	0
316	T.CD4_Tcm.baseline	0.60	Nonsignificant	1.00	0.63	Other	61	31
317	EPI.salivary_serous_acinar.seromucous_like	0.60	Nonsignificant	—	0.00	Other	0	0
318	EPI.colonocyte.goblet_interface	0.59	Nonsignificant	—	1.02	Other	11	21
319	GRANU.MAST.activated_repair	0.58	Nonsignificant	—	0.09	Other	0	1
320	HPC.MPP_IEG	0.56	Nonsignificant	0.92	0.56	Other	45	46
321	THYMO.proliferative_G2M	0.55	Nonsignificant	—	0.00	Other	164	413
322	T.CD4_Th2.tissue_adapted	0.55	Nonsignificant	—	0.97	Other	0	0
323	EPI.ectocervical_granular.inflammatory	0.54	Nonsignificant	—	0.00	Other	0	0
324	MONO.CD14.repair_M2_like	0.54	Nonsignificant	1.00	0.05	Other	550	1,495
325	T.CD4_Tcm.Tfh_like	0.53	Nonsignificant	1.00	0.62	Other	102	214
326	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.48	Nonsignificant	—	1.32	Other	0	0
327	MONO.CD16.patrolling	0.47	Nonsignificant	1.61e-04	1.64	Other	797	216
328	T.CD4_naive.Treg_like	0.47	Nonsignificant	0.93	0.63	Other	121	72
329	EPI.cervical_suprabasal.secretory_vesicle	0.44	Nonsignificant	—	0.00	Other	0	0
330	MAC.LAM.lipid_opsonization	0.43	Nonsignificant	1.00	0.78	Other	45	14
331	EPI.ileal_enterocyte_crypt.villus_transition	0.39	Nonsignificant	—	0.87	Other	7	10
332	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.39	Nonsignificant	—	0.85	Other	0	0
333	SCHWN.translation_boost	0.39	Nonsignificant	—	0.00	Other	8	1
334	EPI.gastric_foveolar.baseline	0.38	Nonsignificant	—	0.00	Other	0	0
335	EPI.renal_intercalated_cell_type_A.acid_secretion	0.38	Nonsignificant	2.35e-04	1.68	Other	12	6
336	EPI.tracheal_submucosal_gland.acinar_serous	0.38	Nonsignificant	—	0.00	Other	0	0
337	MAC.LAM.anti_inflammatory	0.35	Nonsignificant	1.00	0.81	Other	86	132
338	GRANU.MAST.resting_granule	0.34	Nonsignificant	—	0.00	Other	0	0
339	DC.pDC.poised_migratory	0.33	Nonsignificant	0.13	1.23	Other	54	95
340	GRANU.MAST.activated_acute	0.32	Nonsignificant	—	0.00	Other	0	0
341	MONO.CD16.hepatic_mac_like	0.32	Nonsignificant	0.46	1.19	Other	803	117
342	EPI.cervical_suprabasal.inflammatory_repair	0.31	Nonsignificant	—	0.00	Other	0	0
343	THYMO.proliferative_S	0.31	Nonsignificant	1.00	0.00	Other	163	418
344	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.30	Nonsignificant	—	0.00	Other	0	0
345	T.CD4_Th2.precursor	0.29	Nonsignificant	—	0.00	Other	0	0
346	CHOND.activated_fibro_like	0.29	Nonsignificant	1.71e-04	1.55	Other	531	188
347	MUSC.early_activation	0.29	Nonsignificant	0.38	1.32	Other	4	32
348	FIB.skin_neurosecretory.baseline	0.28	Nonsignificant	—	0.00	Other	0	0
349	MUSC.quiescent_reservoir	0.27	Nonsignificant	0.38	1.42	Other	2	8
350	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.25	Nonsignificant	—	0.25	Other	0	0
351	T.CD4_transitional.APC_interacting	0.25	Nonsignificant	0.99	0.56	Other	10	14
352	MONO.CD16.inflammatory	0.23	Nonsignificant	1.00	0.41	Other	1,640	168
353	MONO.CD16.baseline	0.23	Nonsignificant	1.00	0.66	Other	50	1
354	CHOND.remodeling	0.22	Nonsignificant	—	0.34	Other	5	0
355	MONO.CD16.platelet_bound	0.22	Nonsignificant	0.67	1.09	Other	372	508
356	MAC.kupffer.stress	0.22	Nonsignificant	0.98	0.19	Other	9	3
357	OPC.proliferative_immune_interact	0.21	Nonsignificant	0.57	1.17	Other	180	373
358	EPI.lung_club_secretory.canonical_surfactant	0.21	Nonsignificant	—	0.75	Other	74	104
359	T.CD4_Treg.tissue_effector	0.20	Nonsignificant	0.58	1.10	Other	16	13
360	T.CD4_Tcm.APC_mimicry	0.19	Nonsignificant	1.00	0.06	Other	54	43
361	MUSC.baseline	0.19	Nonsignificant	0.38	1.21	Other	0	0
362	EPI.lung_club_secretory.ciliogenesis_primed	0.19	Nonsignificant	—	0.37	Other	0	0
363	FIB.skin_sheath.stress_chaperone	0.18	Nonsignificant	—	0.23	Other	0	0
364	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.18	Nonsignificant	—	0.00	Other	0	0
365	OPC.homeostatic	0.18	Nonsignificant	0.57	1.10	Other	394	160
366	EPI.colonocyte.secretory_boost	0.18	Nonsignificant	0.73	1.14	Other	98	91
367	T.CD4_transitional.tissue_enagement	0.17	Nonsignificant	0.99	0.20	Other	5	11
368	EPI.alveolar_type_2.baseline_surfactant	0.17	Nonsignificant	0.24	1.20	Other	64	9
369	OPC.premyelinating	0.17	Nonsignificant	0.89	0.56	Other	185	12
370	FIB.skin_sheath.ECM_immune	0.17	Nonsignificant	—	0.00	Other	0	0
371	EPI.ileal_enterocyte_crypt.baseline	0.17	Nonsignificant	0.88	1.26	Other	11	6
372	EPI.ileal_enterocyte_crypt.bile_transport	0.17	Nonsignificant	0.97	0.68	Other	2	0
373	FIB.suburothelial.inflammatory_prostanoid	0.16	Nonsignificant	—	1.44	Other	0	0
374	EPI.thymic_medullary.stress_APC	0.16	Nonsignificant	0.02	1.63	Other	2	4
375	FIB.skin_sheath.neuro_vascular_interface	0.15	Nonsignificant	—	0.00	Other	0	0
376	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.15	Nonsignificant	0.25	1.18	Other	449	1,034
377	MAC.proliferating.DNA_replication	0.14	Nonsignificant	0.89	0.63	Other	3	6
378	FIB.perivascular_interface.vasomotor_tone	0.14	Nonsignificant	—	0.69	Other	0	0
379	FIB.suburothelial.contractile_myofibroblast	0.14	Nonsignificant	—	0.47	Other	9	0
380	T.CD4_Treg.APC_interactive	0.13	Nonsignificant	0.05	1.16	Other	118	28
381	EPI.renal_intercalated_cell_type_B.baseline	0.13	Nonsignificant	—	0.00	Other	3	1
382	FIB.perivascular_interface.vascular_BM_remodelling	0.13	Nonsignificant	—	0.51	Other	0	0
383	CHOND.pro_inflammatory	0.13	Nonsignificant	1.00	0.72	Other	181	351
384	FIB.barrier_secretory.homeostasis	0.13	Nonsignificant	—	0.17	Other	0	0
385	CHOND.angiogenic	0.11	Nonsignificant	—	0.15	Other	0	0
386	EPI.hepatic_ductular_cholangiocyte.stress	0.11	Nonsignificant	—	1.32	Other	0	0
387	FIB.suburothelial.urothelial_interface	0.11	Nonsignificant	0.65	0.77	Other	9	8
388	MUSC.activated_migratory	0.10	Nonsignificant	0.98	0.11	Other	6	7
389	EPI.ileal_enterocyte_crypt.proliferative_S	0.10	Nonsignificant	0.97	0.40	Other	4	2
390	FIB.hepatic_stellate_cell.fibrogenic	0.09	Nonsignificant	—	0.73	Other	0	0
391	EPI.colonic_enteroendocrine.Lcell_peptide	0.08	Nonsignificant	—	0.00	Other	0	0
392	EC.venous.cardiac_structural	0.08	Nonsignificant	0.26	1.22	Other	102	229
393	EPI.colonocyte.proximal_transport	0.08	Nonsignificant	1.00	0.92	Other	24	12
394	EPI.skin_hair_follicle_companion.activated_migratory	0.08	Nonsignificant	—	0.00	Other	0	0
395	IPSC.proliferative	0.08	Nonsignificant	1.00	0.45	Other	0	0
396	FIB.lung_alveolar.stress_interacting	0.07	Nonsignificant	—	0.97	Other	0	0
397	MEL.neurotrophic_migratory	0.07	Nonsignificant	—	1.74	Other	0	0
398	EPI.thymic_medullary.hormone_xeno_barrier	0.07	Nonsignificant	—	0.33	Other	0	8
399	FIB.suburothelial.homeostasis_matrix	0.07	Nonsignificant	0.65	0.88	Other	258	921
400	EC.heart_remodeling.capillary_metabolic	0.06	Nonsignificant	0.04	1.37	Other	54	414
401	EC.arterial.arteriole_interface	0.06	Nonsignificant	0.30	1.33	Other	31	12
402	FIB.hepatic_stellate_cell.inflammatory	0.06	Nonsignificant	—	0.00	Other	0	0
403	IPSC.endoderm_primed	0.06	Nonsignificant	1.00	0.85	Other	0	0
404	EPI.skin_hair_follicle_bulge.quiescent	0.06	Nonsignificant	0.14	1.32	Other	56	69
405	EC.arterial.elastic	0.05	Nonsignificant	0.60	1.20	Other	22	45
406	SMC.metabolic	0.05	Nonsignificant	0.51	1.21	Other	14	40
407	T.CD4_Treg.central_naive_like	0.05	Nonsignificant	0.78	0.87	Other	333	45
408	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.05	Nonsignificant	—	0.00	Other	2	0
409	FIB.barrier_purinergic.lipid_secretory	0.04	Nonsignificant	—	0.48	Other	0	0
410	EPI.tracheal_suprabasal.secretory_immune	0.04	Nonsignificant	—	0.64	Other	0	0
411	EC.liver_sinusoidal.prostanoid	0.04	Nonsignificant	—	1.21	Other	11	64
412	EPI.renal_distal_tubule.repair	0.04	Nonsignificant	—	0.72	Other	34	102
413	FIB.interstitial.remodeling	0.04	Nonsignificant	0.90	1.17	Other	31	9
414	IPSC.neural_primed	0.04	Nonsignificant	1.00	0.77	Other	0	0
415	EPI.salivary_duct_ion_transport.baseline	0.04	Nonsignificant	—	—	Other	0	0
416	SCHWN.reactive_inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
417	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.04	Nonsignificant	4.92e-03	1.39	Other	11	22
418	FIB.transitioning.motility_remodelling	0.04	Nonsignificant	—	0.17	Other	0	0
419	EC.heart_remodeling.angiocrine	0.04	Nonsignificant	2.89e-03	1.28	Other	182	525
420	EPI.skin_interfollicular_spinous.upper_lipid	0.04	Nonsignificant	—	1.64	Other	6	6
421	IPSC.mesenchymal_primed	0.04	Nonsignificant	1.00	0.34	Other	0	0
422	EPI.skin_hair_follicle_bulge.anagen_growth	0.04	Nonsignificant	—	0.27	Other	0	0
423	DC.pDC.immature_metabolic	0.04	Nonsignificant	0.97	0.90	Other	78	124
424	FIB.perivascular_interface.lipid_shuttle	0.04	Nonsignificant	—	0.00	Other	51	170
425	FIB.skin_tenogenic.baseline	0.04	Nonsignificant	—	0.00	Other	0	2
426	ASPC.preadipocyte_lipid_primed	0.03	Nonsignificant	1.00	0.91	Other	331	129
427	ASPC.activated	0.03	Nonsignificant	1.00	0.88	Other	164	162
428	EPI.thymic_medullary.canonical_alarmin	0.03	Nonsignificant	0.93	0.44	Other	8	17
429	ASPC.inflammatory	0.03	Nonsignificant	1.00	1.15	Other	21	61
430	FIB.hepatic_stellate_cell.contractile	0.03	Nonsignificant	—	0.00	Other	0	0
431	EPI.esophageal_basal.activated_progenitor	0.03	Nonsignificant	0.52	1.13	Other	1	0
432	MAC.LAM.lipid_phagocytosis	0.03	Nonsignificant	1.00	0.64	Other	369	328
433	FIB.interstitial.immune_interact	0.03	Nonsignificant	0.90	1.06	Other	12	1
434	PERI.baseline	0.03	Nonsignificant	0.02	1.37	Other	39	66
435	EPI.renal_distal_tubule.ciliated_remodelling	0.02	Nonsignificant	—	1.04	Other	0	0
436	EC.liver_sinusoidal.hypoxia_metabolic	0.02	Nonsignificant	1.00	1.01	Other	183	107
437	ASPC.secretory	0.02	Nonsignificant	1.00	0.84	Other	76	5
438	EC.arterial.ion_pump	0.02	Nonsignificant	0.99	0.90	Other	3	2
439	EPI.renal_thick_ascending_limb.salt_sensing	0.02	Nonsignificant	0.65	1.29	Other	73	103
440	MEL.dedifferentiated_migratory	0.02	Nonsignificant	—	0.68	Other	0	0
441	EC.arterial.homeostatic	0.02	Nonsignificant	0.99	0.89	Other	24	3
442	EPI.colonic_tuft.activated	0.02	Nonsignificant	—	0.73	Other	0	0
443	PERI.cardiac_skeletal	0.02	Nonsignificant	0.02	1.30	Other	313	630
444	EC.arterial.arteriole_gas_exchange	0.02	Nonsignificant	0.99	0.84	Other	238	131
445	ASPC.niche_keeping_progenitor	0.02	Nonsignificant	1.00	1.04	Other	52	219
446	FIB.skin_papillary.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
447	CHOND.articular_collagen	0.02	Nonsignificant	1.00	0.00	Other	551	266
448	EC.venous.baseline	0.02	Nonsignificant	0.26	1.06	Other	346	807
449	EPI.salivary_duct_excretory.stress	0.02	Nonsignificant	0.08	1.49	Other	33	68
450	FIB.lung_alveolar.mito_secretory	0.02	Nonsignificant	—	0.00	Other	0	0
451	EC.capillary.angiocrine	0.02	Nonsignificant	0.44	1.12	Other	250	630
452	PERI.inflammatory	0.02	Nonsignificant	0.31	1.11	Other	40	77
453	FIB.reticular.stromal_niche	0.02	Nonsignificant	0.41	1.17	Other	0	0
454	EC.arterial.metabolic	0.02	Nonsignificant	0.99	0.89	Other	195	159
455	EPI.pancreatic_islet.delta	0.02	Nonsignificant	—	0.13	Other	0	0
456	SMC.activated	0.02	Nonsignificant	0.71	1.01	Other	2	5
457	EPI.esophageal_basal.junctional_barrier	0.01	Nonsignificant	—	0.00	Other	0	0
458	ASPC.baseline	0.01	Nonsignificant	1.00	0.69	Other	363	170
459	IPSC.neuroendocrine_primed	0.01	Nonsignificant	—	0.00	Other	0	0
460	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.01	Nonsignificant	—	0.50	Other	6	9
461	SMC.contractile	0.01	Nonsignificant	0.92	0.70	Other	80	588
462	EC.arterial.mito_contact	0.01	Nonsignificant	0.99	0.59	Other	14	5
463	FIB.interstitial.mesenchymal_regulator	0.01	Nonsignificant	0.90	0.99	Other	4	4
464	EPI.renal_immature_ureteric_bud.osmoprotective	0.01	Nonsignificant	0.66	1.08	Other	126	44
465	FIB.transitioning.matrix_stress	0.01	Nonsignificant	—	0.00	Other	47	138
466	EC.capillary.inflammatory	0.01	Nonsignificant	0.73	1.00	Other	27	51
467	EPI.thymic_medullary.proliferative_APC	0.01	Nonsignificant	—	0.00	Other	0	0
468	EC.capillary.migratory	0.01	Nonsignificant	0.44	1.15	Other	181	509
469	EPI.colonocyte.junction_remodeling	9.92e-03	Nonsignificant	1.00	0.49	Other	218	305
470	FIB.transitioning.ISG_primed_interface	9.71e-03	Nonsignificant	—	0.41	Other	17	80
471	EC.arterial.inflammatory	9.00e-03	Nonsignificant	0.99	0.48	Other	63	50
472	EPI.colonocyte.crypt_progenitor	8.75e-03	Nonsignificant	1.00	0.28	Other	115	265
473	EPI.bile_duct_cholangiocyte.secretory_mucin	8.71e-03	Nonsignificant	—	0.07	Other	7	12
474	EPI.renal_principal_cell.canonical_vasopressin	8.47e-03	Nonsignificant	0.31	1.45	Other	2	0
475	EC.venous.adipose_lipid	8.25e-03	Nonsignificant	0.11	1.21	Other	254	476
476	ASPC.remodeling	7.64e-03	Nonsignificant	1.00	0.84	Other	106	354
477	PERI.angiocrine	7.19e-03	Nonsignificant	1.00	0.53	Other	93	102
478	NEU.EXC_IT.structural	7.14e-03	Nonsignificant	0.09	1.12	Other	171	41
479	EPI.pancreatic_ductal_perivascular.baseline	7.08e-03	Nonsignificant	0.69	0.86	Other	1	5
480	ASPC.adipocyte_capillary_interface	6.88e-03	Nonsignificant	1.00	0.70	Other	21	54
481	EPI.colonic_tuft.homeostatic	6.79e-03	Nonsignificant	—	0.00	Other	0	0
482	EPI.pancreatic_islet.beta	6.45e-03	Nonsignificant	1.00	0.00	Other	42	57
483	EC.venous.activated	6.45e-03	Nonsignificant	0.26	1.09	Other	247	752
484	EC.capillary.activated	6.44e-03	Nonsignificant	0.44	1.21	Other	2	5
485	FIB.reticular.immune_interface	6.38e-03	Nonsignificant	—	0.00	Other	1	6
486	EPI.alveolar_type_1.baseline	6.29e-03	Nonsignificant	0.49	1.22	Other	8	0
487	EPI.alveolar_type_1.activated	6.12e-03	Nonsignificant	—	0.00	Other	0	0
488	T.CD4_Treg.Tr1_like	5.98e-03	Nonsignificant	—	0.00	Other	8	8
489	FIB.neurolectin_mucosa.remodeling_repair	5.85e-03	Nonsignificant	—	0.27	Other	4	2
490	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	5.77e-03	Nonsignificant	—	0.73	Other	0	0
491	EPI.pancreatic_acinar.stress	5.69e-03	Nonsignificant	0.54	1.26	Other	28	28
492	EC.capillary.baseline	5.64e-03	Nonsignificant	0.73	0.98	Other	246	560
493	FIB.interstitial.lipid_matrix	5.60e-03	Nonsignificant	1.00	0.77	Other	258	191
494	FIB.neurolectin_mucosa.axon_responsive	5.54e-03	Nonsignificant	0.62	1.12	Other	10	10
495	EC.capillary.stress	5.39e-03	Nonsignificant	0.73	0.94	Other	44	36
496	MEL.stress_glucocorticoid	5.32e-03	Nonsignificant	0.97	0.88	Other	11	34
497	EC.heart_remodeling.remodeling_secretory	5.20e-03	Nonsignificant	1.00	0.81	Other	605	1,341
498	EPI.pancreatic_acinar.inflammatory_regenerative	5.07e-03	Nonsignificant	0.54	1.33	Other	25	113
499	EPI.renal_intercalated_cell_type_A.PC_transitional	4.70e-03	Nonsignificant	—	0.00	Other	203	407
500	NEU.INH_VIP.enkephalinergic	4.63e-03	Nonsignificant	—	1.68	Other	0	0
501	MEL.secretory_quiescent	4.57e-03	Nonsignificant	0.97	0.79	Other	19	13
502	EC.capillary.postcap_venule	4.40e-03	Nonsignificant	0.73	1.03	Other	355	261
503	EPI.pancreatic_ductal_perivascular.protective_antioxidant	4.37e-03	Nonsignificant	—	0.00	Other	11	69
504	EPI.alveolar_type_2.stress_response	4.28e-03	Nonsignificant	1.00	0.67	Other	675	1,562
505	EC.heart_remodeling.remodeling_stalk	4.03e-03	Nonsignificant	1.00	0.85	Other	33	111
506	EC.lymphatic.tip_migratory	4.00e-03	Nonsignificant	0.75	1.11	Other	23	37
507	FIB.neurolectin_mucosa.nerve_interface	3.75e-03	Nonsignificant	—	0.02	Other	4	0
508	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	3.74e-03	Nonsignificant	—	0.10	Other	0	0
509	EPI.salivary_duct_excretory.baseline	3.66e-03	Nonsignificant	0.99	0.25	Other	23	57
510	EC.capillary.angiogenic_tip	3.66e-03	Nonsignificant	0.73	1.01	Other	186	218
511	DC.pDC.baseline	3.57e-03	Nonsignificant	0.97	0.62	Other	88	123
512	EPI.esophageal_suprabasal.differentiating_keratin	3.53e-03	Nonsignificant	0.30	1.19	Other	131	61
513	FIB.tracheal_subepithelial.baseline	3.51e-03	Nonsignificant	—	0.00	Other	0	0
514	EC.heart_remodeling.activated_acute	3.45e-03	Nonsignificant	1.00	0.69	Other	102	186
515	EC.heart_remodeling.translation_boost	3.41e-03	Nonsignificant	—	0.00	Other	0	0
516	EC.lymphatic.activated	3.37e-03	Nonsignificant	0.84	0.89	Other	47	73
517	EC.lymphatic.baseline	3.36e-03	Nonsignificant	0.75	1.05	Other	38	72
518	EPI.pancreatic_ductal_progenitor.ADM_like	3.23e-03	Nonsignificant	—	1.26	Other	0	0
519	EC.arterial.angiogenic_tip	3.10e-03	Nonsignificant	—	0.00	Other	30	37
520	FIB.interstitial.mesenchymal_APC	3.06e-03	Nonsignificant	1.00	0.53	Other	81	33
521	EPI.pancreatic_ductal_bicarbonate.inflammatory	3.03e-03	Nonsignificant	0.11	1.42	Other	14	32
522	EPI.renal_thick_ascending_limb.remodeling	2.99e-03	Nonsignificant	0.70	1.16	Other	152	92
523	OLG.myelinating_mature	2.65e-03	Nonsignificant	0.17	1.06	Other	363	94
524	EPI.skin_keratinocyte_progenitor.activated_stress	2.64e-03	Nonsignificant	—	0.38	Other	0	0
525	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	2.63e-03	Nonsignificant	—	0.00	Other	0	0
526	MEL.mature_oxidative_traffic	2.59e-03	Nonsignificant	0.97	0.40	Other	247	285
527	EC.venous.quiescent_homeostatic	2.53e-03	Nonsignificant	1.00	0.79	Other	456	360
528	EPI.renal_immature_ureteric_bud.defense_secretory	2.51e-03	Nonsignificant	0.66	1.10	Other	45	76
529	FIB.neurolectin_mucosa.inflammatory	2.50e-03	Nonsignificant	0.62	0.92	Other	52	110
530	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.50e-03	Nonsignificant	—	0.73	Other	0	0
531	EPI.skin_keratinocyte_basal.transit_amplifying	2.41e-03	Nonsignificant	—	0.97	Other	0	0
532	EC.liver_sinusoidal.inflammatory	2.20e-03	Nonsignificant	—	0.00	Other	223	154
533	EPI.lung_multiciliated.mature_motile_cilia	2.13e-03	Nonsignificant	—	1.53	Other	0	0
534	ASPC.proliferative	1.98e-03	Nonsignificant	1.00	0.58	Other	33	85
535	FIB.interstitial.stress_secretory	1.88e-03	Nonsignificant	0.90	0.95	Other	92	56
536	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	1.63e-03	Nonsignificant	0.11	1.37	Other	219	533
537	FIB.transitioning.secretory_procollagen	1.63e-03	Nonsignificant	—	5.55e-17	Other	0	0
538	OLG.stress	1.63e-03	Nonsignificant	4.84e-03	1.12	Other	232	8
539	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.59e-03	Nonsignificant	—	0.97	Other	0	0
540	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	1.56e-03	Nonsignificant	—	0.19	Other	5	3
541	EPI.renal_principal_cell.injury_repair	1.54e-03	Nonsignificant	0.97	0.87	Other	26	9
542	EPI.renal_principal_cell.activated_acute	1.53e-03	Nonsignificant	0.97	1.05	Other	29	59
543	EPI.salivary_myoepithelial.contractile_repair	1.53e-03	Nonsignificant	—	0.19	Other	3	9
544	EC.heart_remodeling.perivascular	1.50e-03	Nonsignificant	1.00	0.52	Other	124	408
545	NEU.INH_VIP.regulatory_remodeling	1.46e-03	Nonsignificant	—	0.85	Other	6	1
546	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.42e-03	Nonsignificant	0.87	0.91	Other	322	317
547	FIB.reticular.stress_metallothionein	1.33e-03	Nonsignificant	—	0.00	Other	3	32
548	ASPC.stem_like_progenitor	1.31e-03	Nonsignificant	1.00	0.23	Other	300	842
549	EPI.skin_sweat_duct_keratinocyte.repair	1.11e-03	Nonsignificant	—	1.52	Other	0	0
550	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.11e-03	Nonsignificant	—	0.00	Other	0	0
551	NEU.INH_VIP.LAMP5_hybrid	1.06e-03	Nonsignificant	—	0.96	Other	1	9
552	EPI.salivary_myoepithelial.baseline	1.03e-03	Nonsignificant	0.64	1.19	Other	42	141
553	EPI.alveolar_type_2.injury_primed	1.03e-03	Nonsignificant	1.00	0.43	Other	434	245
554	EPI.salivary_intercalated_defense.inflammatory	9.86e-04	Nonsignificant	1.00	0.12	Other	152	360
555	EPI.skin_hair_follicle_bulge.niche_crosstalk	9.84e-04	Nonsignificant	—	0.00	Other	29	88
556	EPI.renal_thick_ascending_limb.barrier_repair	9.77e-04	Nonsignificant	0.87	1.00	Other	141	284
557	EPI.esophageal_suprabasal.basal_transitional	9.69e-04	Nonsignificant	0.64	0.91	Other	44	67
558	NEU.INH_LAMP5.glial_interface	9.35e-04	Nonsignificant	—	1.02	Other	0	0
559	FIB.barrier_secretory.remodeling	9.30e-04	Nonsignificant	—	0.00	Other	0	0
560	FIB.reticular.ECM_builder	9.24e-04	Nonsignificant	—	0.00	Other	0	0
561	EPI.salivary_mucous_acinar.baseline	7.88e-04	Nonsignificant	—	—	Other	394	683
562	OLG.myelinating_stress	7.81e-04	Nonsignificant	0.95	0.97	Other	232	62
563	EPI.pancreatic_ductal_bicarbonate.stress	7.53e-04	Nonsignificant	—	0.00	Other	12	33
564	EPI.skin_keratinocyte_basal.spinous_transition	7.27e-04	Nonsignificant	—	0.00	Other	0	0
565	IPSC.midbrain_primed	7.27e-04	Nonsignificant	1.00	0.21	Other	0	0
566	EPI.pancreatic_ductal_progenitor.baseline	7.02e-04	Nonsignificant	0.90	0.68	Other	179	702
567	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	6.10e-04	Nonsignificant	—	0.18	Other	49	237
568	ASTRO.stress_acute	6.09e-04	Nonsignificant	1.00	0.37	Other	60	56
569	EPI.pancreatic_ductal_bicarbonate.baseline	5.92e-04	Nonsignificant	0.90	0.76	Other	11	42
570	ASTRO.neuromodulatory	5.90e-04	Nonsignificant	1.00	0.35	Other	34	172
571	NEU.INH_LAMP5.projecting	5.72e-04	Nonsignificant	—	0.46	Other	0	0
572	SKM.type_2_fast.oxidative_IIa	5.50e-04	Nonsignificant	0.13	1.18	Other	946	56
573	EPI.salivary_myoepithelial.activated	4.97e-04	Nonsignificant	0.90	0.68	Other	85	281
574	OLG.vesicle_trafficking	4.61e-04	Nonsignificant	0.69	1.07	Other	124	10
575	EPI.renal_thick_ascending_limb.cation_flux	4.41e-04	Nonsignificant	0.88	0.69	Other	57	95
576	NEU.INH_PVALB.nuclear_reg	4.19e-04	Nonsignificant	0.13	1.34	Other	25	12
577	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	3.90e-04	Nonsignificant	0.18	1.29	Other	2	9
578	EPI.renal_principal_cell.intercalated_like	3.86e-04	Nonsignificant	0.97	0.48	Other	63	66
579	EPI.lung_club_secretory.inflammatory	3.79e-04	Nonsignificant	—	0.00	Other	0	0
580	NEU.EXC_CT.remodeling	3.46e-04	Nonsignificant	—	0.63	Other	23	1
581	EPI.pancreatic_ductal_bicarbonate.activated	3.44e-04	Nonsignificant	0.90	0.70	Other	10	7
582	NEU.INH_LAMP5.rosehip	3.36e-04	Nonsignificant	—	0.00	Other	0	0
583	EPI.salivary_myoepithelial.junctional_transport	3.21e-04	Nonsignificant	0.90	0.64	Other	66	121
584	EPI.skin_interfollicular_spinous.baseline	2.95e-04	Nonsignificant	1.00	0.95	Other	35	3
585	NEU.INH_VIP.serotonergic	2.91e-04	Nonsignificant	—	0.14	Other	9	2
586	EC.lymphatic.scavenger	2.81e-04	Nonsignificant	1.00	0.10	Other	203	257
587	EPI.extrahepatic_cholangiocyte.barrier_interface	2.77e-04	Nonsignificant	—	0.00	Other	0	0
588	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.65e-04	Nonsignificant	0.90	0.96	Other	40	191
589	NEU.INH_LAMP5.exc_inh_balance	2.60e-04	Nonsignificant	—	0.00	Other	46	2
590	NEU.INH_VIP.matrix	2.49e-04	Nonsignificant	—	0.26	Other	24	77
591	EC.venous.remodeling_stalk	2.45e-04	Nonsignificant	1.00	0.44	Other	559	566
592	EPI.lung_multiciliated.baseline	2.37e-04	Nonsignificant	—	0.51	Other	0	7
593	SKM.type_1_slow.glycolytic	2.34e-04	Nonsignificant	0.21	1.42	Other	362	647
594	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	2.33e-04	Nonsignificant	—	0.57	Other	0	0
595	EPI.ectocervical_granular.proliferative_basal	2.25e-04	Nonsignificant	—	0.00	Other	0	0
596	NEU.INH_VIP.develop_niche	2.24e-04	Nonsignificant	—	0.45	Other	0	0
597	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.13e-04	Nonsignificant	—	0.00	Other	0	0
598	EPI.endocervical_secretory.squamous_barrier	2.13e-04	Nonsignificant	—	0.67	Other	0	0
599	EPI.skin_follicular_keratinizing.root_infundibulum	1.90e-04	Nonsignificant	—	0.76	Other	0	0
600	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.90e-04	Nonsignificant	—	0.42	Other	0	0
601	PLAT.adhesion	1.85e-04	Nonsignificant	—	0.48	Other	0	0
602	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.83e-04	Nonsignificant	—	0.00	Other	0	0
603	EPI.pancreatic_ductal_progenitor.ciliated_transport	1.77e-04	Nonsignificant	—	0.00	Other	105	368
604	EPI.renal_principal_cell.inflammatory	1.77e-04	Nonsignificant	0.97	0.27	Other	74	157
605	NEU.EXC_SYT2.synaptic	1.71e-04	Nonsignificant	—	0.00	Other	0	0
606	EPI.renal_distal_tubule.immune_modulatory	1.66e-04	Nonsignificant	—	0.14	Other	0	0
607	EPI.skin_interfollicular_spinous.stress_UPR	1.61e-04	Nonsignificant	—	0.45	Other	0	0
608	ASTRO.A1_reactive	1.54e-04	Nonsignificant	1.00	0.13	Other	433	394
609	SKM.type_1_slow.contractile	1.45e-04	Nonsignificant	0.62	0.94	Other	596	8
610	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.39e-04	Nonsignificant	—	0.00	Other	0	0
611	EC.liver_sinusoidal.remodeling_lipotoxicity	1.39e-04	Nonsignificant	—	0.00	Other	90	58
612	SKM.type_1_slow.oxidative	1.31e-04	Nonsignificant	0.62	0.94	Other	802	251
613	SKM.type_2_fast.glycolytic_IIx_IIb	1.28e-04	Nonsignificant	0.90	0.70	Other	565	1,482
614	NEU.INH_VIP.canonical_disinhibitory	1.17e-04	Nonsignificant	0.81	0.70	Other	59	38
615	NEU.EXC_CT.projector	1.17e-04	Nonsignificant	0.65	0.96	Other	87	26
616	EPI.skin_sweat_duct_keratinocyte.barrier	1.15e-04	Nonsignificant	—	0.60	Other	0	0
617	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	1.05e-04	Nonsignificant	0.98	1.00	Other	7	16
618	FIB.barrier_purinergic.stress_GF_binding	9.62e-05	Nonsignificant	—	0.00	Other	0	0
619	EPI.skin_interfollicular_spinous.early_differentiation	8.49e-05	Nonsignificant	1.00	0.70	Other	89	19
620	NEU.INH_VIP.cannabinoid	8.47e-05	Nonsignificant	—	0.00	Other	0	0
621	OLG.regulatory_activated	8.47e-05	Nonsignificant	0.95	0.97	Other	196	614
622	EPI.tracheal_basal.activated_stress	8.15e-05	Nonsignificant	0.01	1.30	Other	32	0
623	NEU.INH_VIP.nuclear_reg	7.73e-05	Nonsignificant	—	0.00	Other	20	4
624	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	7.49e-05	Nonsignificant	—	0.00	Other	0	0
625	EPI.skin_interfollicular_spinous.inflammatory	6.81e-05	Nonsignificant	—	0.00	Other	0	0
626	EPI.lung_multiciliated.stress	6.20e-05	Nonsignificant	—	0.00	Other	67	165
627	EPI.esophageal_suprabasal.proliferative_S	5.90e-05	Nonsignificant	—	0.00	Other	26	41
628	EPI.pancreatic_acinar.adhesion_remodeling	5.48e-05	Nonsignificant	0.85	1.13	Other	210	784
629	MAC.LAM.perivascular_angiocrine	5.14e-05	Nonsignificant	—	0.00	Other	53	138
630	EPI.hepatic_ductular_cholangiocyte.ion_transport	4.72e-05	Nonsignificant	—	0.00	Other	0	0
631	EPI.hepatic_ductular_cholangiocyte.polarity	4.61e-05	Nonsignificant	—	0.00	Other	0	0
632	NEU.INH_PVALB.chandelier	4.35e-05	Nonsignificant	0.53	1.00	Other	19	16
633	NEU.INH_VIP.excitatory_coupled	3.38e-05	Nonsignificant	—	0.00	Other	13	0
634	EPI.salivary_intercalated_defense.basal_EMT	2.93e-05	Nonsignificant	—	0.00	Other	0	0
635	IPSC.mesodermal_primed	2.81e-05	Nonsignificant	1.00	0.08	Other	0	0
636	NEU.INH_VIP.opioid	2.74e-05	Nonsignificant	—	0.00	Other	50	9
637	EPI.endocervical_secretory.secretory_translocon	2.65e-05	Nonsignificant	—	0.00	Other	0	0
638	EPI.skin_sebaceous_duct_luminal.detox_repair	2.51e-05	Nonsignificant	0.72	0.93	Other	137	94
639	NEU.INH_PVALB.neuromodulatory	2.38e-05	Nonsignificant	—	0.27	Other	0	0
640	PLAT.megakaryocytic	2.30e-05	Nonsignificant	—	0.00	Other	0	0
641	EPI.esophageal_suprabasal.proliferative_G2M	2.15e-05	Nonsignificant	—	0.00	Other	0	0
642	EPI.skin_follicular_keratinizing.transit_amplifying	2.03e-05	Nonsignificant	—	0.00	Other	21	49
643	EC.liver_sinusoidal.secretory_lipoprotein	1.98e-05	Nonsignificant	1.00	0.35	Other	120	70
644	EPI.renal_distal_tubule.ion_transport	1.60e-05	Nonsignificant	—	0.00	Other	0	0
645	EPI.pancreatic_acinar.baseline	1.50e-05	Nonsignificant	0.96	0.66	Other	274	163
646	EPI.esophageal_suprabasal.proliferative_exit	1.45e-05	Nonsignificant	—	0.00	Other	0	0
647	OLG.reactive_repair	1.32e-05	Nonsignificant	1.00	0.61	Other	385	385
648	NEU.INH_PVALB.fastspike	1.30e-05	Nonsignificant	—	0.00	Other	24	22
649	EPI.skin_interfollicular_spinous.stress_oxidative	1.25e-05	Nonsignificant	—	0.00	Other	0	0
650	EPI.skin_follicular_keratinizing.upper_infundibulum	1.19e-05	Nonsignificant	—	0.20	Other	8	2
651	EPI.pancreatic_acinar.metabolic_onecarbon	1.08e-05	Nonsignificant	0.96	0.62	Other	287	328
652	EPI.skin_appendage_keratinocyte.transit_amplifying	9.48e-06	Nonsignificant	—	0.00	Other	109	358
653	EPI.renal_distal_tubule.stress	8.91e-06	Nonsignificant	—	0.00	Other	0	0
654	EPI.pancreatic_acinar.quiet_dedifferentiation	7.49e-06	Nonsignificant	0.96	0.67	Other	142	171
655	EPI.tracheal_basal.homeostatic_progenitor	5.71e-06	Nonsignificant	0.97	0.57	Other	285	74
656	NEU.EXC_SYT2.nuclear_reg	5.50e-06	Nonsignificant	—	0.00	Other	0	0
657	EPI.tracheal_suprabasal.transitional_wound	5.01e-06	Nonsignificant	—	0.00	Other	16	1
658	NEU.EXC_CT.Ca2_signaling	4.76e-06	Nonsignificant	—	0.00	Other	68	17
659	NEU.EXC_IT.neuromodulated	4.08e-06	Nonsignificant	0.50	1.14	Other	176	116
660	NEU.INH_PVALB.metabotropic	3.24e-06	Nonsignificant	—	0.00	Other	0	0
661	EPI.thymic_cortical.secretory_remodeling	2.22e-06	Nonsignificant	—	0.85	Other	4	1
662	OLG.regulatory	1.99e-06	Nonsignificant	1.00	0.46	Other	353	73
663	EPI.lung_club_secretory.ciliogenesis_axoneme	1.88e-06	Nonsignificant	—	0.00	Other	0	0
664	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.58e-06	Nonsignificant	—	0.67	Other	0	0
665	EC.liver_sinusoidal.stress	1.20e-06	Nonsignificant	—	0.00	Other	413	158
666	EPI.skin_interfollicular_spinous.transition_basal	7.91e-07	Nonsignificant	1.00	0.13	Other	100	127
667	NEU.EXC_CT.Ca2_sensor	7.35e-07	Nonsignificant	—	0.00	Other	0	0
668	EPI.skin_keratinocyte_proliferating.early_spinous_transition	6.35e-07	Nonsignificant	—	0.75	Other	135	290
669	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	5.65e-07	Nonsignificant	0.98	0.55	Other	33	34
670	NEU.INH_PVALB.serotonergic	3.74e-07	Nonsignificant	—	0.00	Other	0	0
671	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.35e-07	Nonsignificant	—	0.28	Other	0	0
672	NEU.EXC_IT.transitional	1.14e-07	Nonsignificant	1.00	0.95	Other	237	142
673	EPI.skin_keratinocyte_basal.basement_anchoring	7.88e-08	Nonsignificant	—	0.00	Other	0	0
674	EPI.skin_interfollicular_spinous.proliferative	5.97e-08	Nonsignificant	—	0.00	Other	0	0
675	NEU.EXC_IT.adhesion	4.46e-08	Nonsignificant	1.00	0.87	Other	252	108
676	EPI.skin_keratinocyte_proliferating.anchor_remodel	3.05e-08	Nonsignificant	—	0.00	Other	0	0
677	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.58e-08	Nonsignificant	—	0.00	Other	0	0
678	EPI.skin_sweat_duct_keratinocyte.signal_gate	9.15e-09	Nonsignificant	—	0.00	Other	43	26
679	NEU.EXC_NTNG1.synaptic	6.40e-09	Nonsignificant	—	0.67	Other	0	0
680	NEU.EXC_IT.callosal	6.04e-09	Nonsignificant	1.00	0.76	Other	286	119
681	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	4.06e-09	Nonsignificant	—	0.00	Other	0	0
682	NEU.EXC_IT.guidance	7.65e-10	Nonsignificant	1.00	0.49	Other	274	63
683	EPI.skin_sebaceous_duct_luminal.immune_interface	1.81e-10	Nonsignificant	—	0.00	Other	0	0
684	EPI.skin_sweat_duct_keratinocyte.proliferative_S	9.23e-11	Nonsignificant	—	0.00	Other	0	0
685	EPI.skin_keratinocyte_proliferating.detox_repair	2.26e-12	Nonsignificant	—	0.00	Other	0	0
686	EPI.thymic_cortical.Notch_interface	2.14e-12	Nonsignificant	—	0.27	Other	82	137
687	NEU.EXC_NTNG1.nuclear_reg	1.91e-13	Nonsignificant	—	0.00	Other	0	0
688	EPI.thymic_cortical.baseline	1.61e-13	Nonsignificant	0.98	0.36	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

32 unique genes. Showing 1–32. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
AMDHD1	01-High	0.62	10.21	G1	C1	—	T.CD8_Tem.early_helper_like (Tier: specific) ILC2.quiescent (Tier: relevant)	11 cells — complete matches	3	10
CYP24A1	02-Medium	0.59	15.86	G1	C2	—	—	16 cells — complete matches	6	24
CCDC38	02-Medium	0.55	9.88	G2	C1	—	T.CD8_Tem.early_helper_like (Tier: specific)	21 cells — complete matches	3	5
ENSG00000302609	02-Medium	0.55	9.80	G2	C1	—	—	—	3	5
PDE3B	02-Medium	0.55	11.52	G1	C2	—	adipocyte (Tier: specific) ADIPO.adipocyte (Tier: specific) T.CD4_naive.activated_stress (Tier: specific) T.CD8_Tem.TEMRA (Tier: specific) ADIPO.hypoxia_remodelling (Tier: relevant) ADIPO.inflammatory (Tier: relevant) MAC.kupffer.monocyte_like (Tier: relevant)	90 cells — complete matches	9	39
NADSYN1	02-Medium	0.55	13.58	G2	C2	—	FIB.adventitial.activated_remodelling (Tier: relevant)	7 cells — complete matches	1	5
ENSG00000286587	02-Medium	0.52	7.69	G1	C2	—	—	—	11	30
DHCR7	02-Medium	0.50	9.30	G1	C2	GRANU.MAST.resting_granule (L2)	T.CD4_naive.activated_stress (Tier: specific) FIB.adventitial.activated_remodelling (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant)	27 cells — complete matches	1	5
CYP2R1	02-Medium	0.50	9.30	G2	C2	—	—	7 cells — complete matches	1	1
DHCR7-DT	02-Medium	0.50	9.30	G1	C2	—	—	—	1	5
HAL	02-Medium	0.49	9.10	G2	C1	HEP.periportal_metabolic (L1S), HEP.periportal_metabolic.canonical_urea_cycle (L2)	HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) MAC.MDM.inflammatory_phagocytic (Tier: specific) HEP.periportal_metabolic.stress_chaperone (Tier: relevant)	21 cells — complete matches	3	6
GC	02-Medium	0.48	9.30	G1	C2	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2)	HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	22 cells — complete matches	4	8
SEC23A	02-Medium	0.46	5.16	G1	C2	—	—	5 cells — complete matches	11	11
SHANK2	02-Medium	0.46	12.84	G1	C2	—	—	19 cells — complete matches	0	4
ENSG00000259121	02-Medium	0.45	6.87	G2	C1	—	—	—	0	0
SPON1-AS1	02-Medium	0.43	12.88	G2	C2	—	ADIPO.inflammatory (Tier: relevant)	ADIPO.inflammatory (L2)	1	4
PNN-AS1	02-Medium	0.42	4.17	G2	C2	—	—	—	0	0
SEC23A-AS1	02-Medium	0.42	5.05	G1	C2	—	DC.cDC2.adhesion_signaling (Tier: relevant)	15 cells — complete matches	4	4
GEMIN2	02-Medium	0.40	4.79	G1	C2	—	B.memory.preactivated (Tier: specific) T.CD4_naive.activated_stress (Tier: specific)	10 cells — complete matches	4	4
ENSG00000257878	02-Medium	0.40	9.01	G2	C2	—	—	—	2	3
BCAS1	02-Medium	0.39	7.96	G2	C2	EPI.salivary_serous_acinar.seromucous_like (L2)	NK.cytokine_tissue_activation (Tier: specific) ILC2.quiescent (Tier: relevant)	39 cells — complete matches	7	24
LTA4H	02-Medium	0.39	8.45	G2	C2	DC.cDC1.homeostatic_inhibitory (L2), EPI.lung_club_secretory.canonical_surfactant (L2), MAC.LAM.inflammatory_APC (L2)	—	7 cells — complete matches	2	2
TRAPPC6B	02-Medium	0.39	4.56	G2	C2	—	—	MONO.CD14.remodeling (L2)	0	0
ENSG00000299120	02-Medium	0.38	4.63	G1	C2	—	—	—	4	4
PNN	02-Medium	0.37	4.70	G2	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2)	—	MAC.kupffer.tolerogenic (L2)	0	0
RRAS2	02-Medium	0.37	11.63	G2	C2	—	B.memory.activated (Tier: specific) B.memory.preactivated (Tier: specific)	19 cells — complete matches	2	6
ENSG00000303627	02-Medium	0.35	11.16	G2	C2	—	—	—	0	0
SNRPF	02-Medium	0.34	7.66	G2	C2	—	—	—	3	3
SPON1	02-Medium	0.32	10.81	G2	C2	HPC.CLP_B_primed (L2), NEU.INH_PVALB.metabotropic (L2)	FIB.adventitial.activated_remodelling (Tier: relevant)	74 cells — complete matches	0	1
ENSG00000307189	02-Medium	0.28	4.68	G2	C2	—	—	—	1	1
ENSG00000307169	02-Medium	0.27	4.62	G2	C2	—	—	—	1	1
SNRPF-DT	02-Medium	0.26	3.74	G2	C2	—	—	—	1	1

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.