Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00001237 · All tissues

Radial styloid tenosynovitis [de Quervain]: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Tenosynovitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	macrophage	28.57	Significant	7.80e-27	1.19	Specific	813	1,732
2	microglia	22.48	Significant	0.09	1.13	Relevant	61	129
3	monocyte	11.06	Significant	3.30e-49	1.18	Specific	2,176	3,871
4	dendritic_cell	7.10	Significant	1.00	1.02	Other	496	724
5	endothelial_cell	3.60	Nominal	0.99	1.02	Other	373	974
6	plasma_cell	1.49	Nonsignificant	1.00	0.90	Other	17	24
7	oligodendrocyte_precursor_cell	1.34	Nonsignificant	1.00	0.92	Other	461	1,454
8	granulocyte	1.32	Nonsignificant	1.00	0.90	Other	5	6
9	adipose_stem_and_progenitor_cell	1.30	Nonsignificant	1.00	0.90	Other	327	954
10	thymocyte	0.74	Nonsignificant	1.00	0.83	Other	168	512
11	fibroblast	0.65	Nonsignificant	1.00	0.84	Other	184	826
12	smooth_muscle_cell	0.46	Nonsignificant	1.00	0.81	Other	27	139
13	mesothelial_cell	0.39	Nonsignificant	1.00	0.74	Other	6	36
14	epithelial_cell	0.30	Nonsignificant	1.00	0.75	Other	24	47
15	platelet	0.24	Nonsignificant	—	0.22	Other	85	104
16	B_cell	0.22	Nonsignificant	1.00	0.71	Other	356	694
17	pericyte	0.21	Nonsignificant	1.00	0.75	Other	128	517
18	adipocyte	0.15	Nonsignificant	1.00	0.69	Other	33	111
19	haematopoietic_progenitor_cell	0.15	Nonsignificant	1.00	0.73	Other	262	502
20	chondrocyte	0.09	Nonsignificant	1.00	0.63	Other	548	1,069
21	T_cell	0.07	Nonsignificant	1.00	0.57	Other	470	959
22	schwann_cell	0.04	Nonsignificant	1.00	0.63	Other	10	57
23	cardiomyocyte	0.04	Nonsignificant	1.00	0.60	Other	533	2,045
24	hepatocyte	0.04	Nonsignificant	1.00	0.56	Other	1,515	3,822
25	neuron	0.03	Nonsignificant	1.00	0.63	Other	330	1,328
26	muscle_stem_cell	0.03	Nonsignificant	1.00	0.59	Other	7	27
27	innate_lymphoid_cell_2	0.01	Nonsignificant	1.00	0.49	Other	3	8
28	granulosa_cell	0.01	Nonsignificant	1.00	0.53	Other	293	670
29	astrocyte	0.01	Nonsignificant	1.00	0.45	Other	256	1,203
30	melanocyte	8.64e-03	Nonsignificant	1.00	0.47	Other	97	309
31	natural_killer_cell	2.68e-03	Nonsignificant	1.00	0.53	Other	1,204	2,052
32	induced_pluripotent_stem_cell	2.31e-03	Nonsignificant	1.00	0.36	Other	0	0
33	oligodendrocyte	1.18e-03	Nonsignificant	1.00	0.23	Other	385	1,507
34	skeletal_muscle_cell	9.06e-04	Nonsignificant	1.00	0.46	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MAC.resident_repair	40.74	Significant	1.34e-07	2.19	Specific	796	1,426
2	MAC.LAM	34.07	Significant	1.79e-03	1.60	Specific	914	2,064
3	MAC.resident_cardiac	30.18	Significant	0.23	1.28	Specific	485	1,074
4	MAC.MDM	27.18	Significant	1.00	0.75	Specific	623	986
5	MAC.proliferating	24.47	Significant	1.00	0.54	Relevant	87	253
6	MG.microglia	22.48	Significant	—	—	—	49	0
7	MAC.kupffer	16.10	Significant	1.00	0.75	Relevant	189	530
8	MAC.resident_iron	14.92	Significant	1.00	0.09	Relevant	16	21
9	MAC.microglia_like	13.58	Significant	1.00	0.13	Relevant	124	179
10	MONO.CD14	12.82	Significant	2.00e-50	3.18	Specific	2,294	4,139
11	DC.cDC2	9.29	Significant	2.60e-13	1.89	Specific	1,189	1,793
12	MAC.alveolar	8.54	Significant	1.00	0.04	Relevant	1,432	3,122
13	EC.lymphatic	8.53	Significant	1.36e-04	1.61	Specific	630	998
14	FIB.lung_alveolar	5.77	Significant	—	2.61	Specific	6	15
15	EC.venous	5.49	Nominal	1.47e-08	1.45	Other	516	1,387
16	EC.capillary	3.72	Nominal	0.10	1.13	Other	514	1,635
17	GRANU.neutrophil	3.29	Nominal	9.43e-04	1.51	Other	1,235	2,649
18	EC.arterial	2.30	Nonsignificant	1.00	0.62	Other	356	885
19	EPI.renal_distal_tubule	2.26	Nonsignificant	0.58	1.24	Other	133	361
20	DC.mig	2.13	Nonsignificant	—	0.00	Other	89	156
21	MONO.CD16	1.92	Nonsignificant	0.68	0.93	Other	1,304	1,835
22	FIB.neurolectin_mucosa	1.90	Nonsignificant	0.35	1.17	Other	133	394
23	EPI.colonic_tuft	1.75	Nonsignificant	—	1.74	Other	7	24
24	PC.IgA_muocsal	1.50	Nonsignificant	0.56	0.97	Other	18	31
25	DC.cDC1	1.48	Nonsignificant	1.00	0.50	Other	55	112
26	PC.IgG_systemic	1.43	Nonsignificant	0.56	1.14	Other	41	60
27	EPI.cervical_suprabasal	1.43	Nonsignificant	—	1.47	Other	14	50
28	FIB.transitioning	1.36	Nonsignificant	0.50	1.14	Other	172	497
29	FIB.interstitial	1.34	Nonsignificant	1.91e-08	1.30	Other	288	940
30	OPC.oligodendrocyte_precursor_cell	1.34	Nonsignificant	—	—	Other	413	1,269
31	FIB.barrier_secretory	1.32	Nonsignificant	0.66	1.13	Other	81	228
32	ASPC.adipose_stem_and_progenitor_cell	1.30	Nonsignificant	—	—	Other	324	930
33	EPI.salivary_duct_excretory	1.27	Nonsignificant	0.58	1.18	Other	85	180
34	EPI.colonocyte	1.25	Nonsignificant	4.55e-03	1.21	Other	294	815
35	EPI.renal_intercalated_cell_type_B	1.11	Nonsignificant	—	1.31	Other	6	7
36	EPI.salivary_intercalated_defense	1.05	Nonsignificant	0.87	1.12	Other	81	161
37	EC.liver_sinusoidal	0.96	Nonsignificant	1.00	0.25	Other	1,083	1,925
38	THYMO.thymocyte	0.74	Nonsignificant	—	—	Other	163	495
39	EPI.ectocervical_granular	0.70	Nonsignificant	—	1.17	Other	11	23
40	EPI.skin_sebaceous_duct_luminal	0.66	Nonsignificant	1.00	1.09	Other	100	249
41	FIB.tracheal_subepithelial	0.63	Nonsignificant	—	0.44	Other	0	0
42	T.CD4_Treg	0.61	Nonsignificant	0.05	1.11	Other	244	511
43	EPI.endocervical_secretory	0.59	Nonsignificant	—	0.93	Other	0	0
44	FIB.suburothelial	0.52	Nonsignificant	1.00	0.94	Other	122	432
45	DC.pDC	0.52	Nonsignificant	1.00	0.16	Other	496	1,028
46	EPI.alveolar_type_2	0.50	Nonsignificant	0.87	1.07	Other	813	1,853
47	EPI.skin_keratinocyte_progenitor	0.48	Nonsignificant	—	0.69	Other	0	3
48	EPI.renal_thick_ascending_limb	0.47	Nonsignificant	1.00	1.02	Other	453	1,153
49	SMC.smooth_muscle_cell	0.46	Nonsignificant	—	—	Other	20	101
50	T.CD4_Trm	0.46	Nonsignificant	8.47e-03	1.10	Other	176	363
51	FIB.barrier_purinergic	0.44	Nonsignificant	—	0.39	Other	1	3
52	T.CD4_Tfh	0.44	Nonsignificant	0.29	1.10	Other	47	45
53	B.age_associated	0.43	Nonsignificant	0.76	1.09	Other	207	350
54	HEP.pericentral_lipoprotein	0.40	Nonsignificant	—	2.50	Other	0	0
55	FIB.reticular	0.40	Nonsignificant	1.00	0.72	Other	19	87
56	MESO.mesothelial_cell	0.39	Nonsignificant	—	—	Other	2	18
57	FIB.perivascular_interface	0.39	Nonsignificant	1.00	0.87	Other	0	0
58	EPI.ileal_enterocyte_absorptive	0.38	Nonsignificant	1.00	1.03	Other	118	338
59	EPI.lung_club_secretory	0.38	Nonsignificant	1.00	0.87	Other	5	14
60	FIB.hepatic_stellate_cell	0.32	Nonsignificant	—	0.24	Other	64	252
61	T.CD4_transitional	0.31	Nonsignificant	0.33	1.07	Other	48	110
62	EPI.skin_hair_follicle_bulge	0.30	Nonsignificant	1.00	0.97	Other	51	178
63	B.naive	0.27	Nonsignificant	3.68e-04	1.25	Other	307	595
64	EPI.pancreatic_ductal_bicarbonate	0.27	Nonsignificant	1.00	0.97	Other	131	548
65	EPI.tracheal_basal	0.27	Nonsignificant	1.00	0.91	Other	398	1,120
66	EPI.pancreatic_acinar	0.25	Nonsignificant	1.00	1.00	Other	429	1,475
67	PLAT.platelet	0.24	Nonsignificant	—	0.00	Other	38	53
68	EPI.bile_duct_cholangiocyte	0.23	Nonsignificant	1.00	0.97	Other	37	60
69	EPI.skin_sweat_duct_keratinocyte	0.23	Nonsignificant	4.55e-03	1.38	Other	146	301
70	PERI.pericyte	0.21	Nonsignificant	—	—	Other	117	0
71	GRANU.MAST	0.19	Nonsignificant	1.00	0.00	Other	5	6
72	EPI.salivary_serous_acinar	0.19	Nonsignificant	1.00	0.86	Other	233	531
73	EPI.pancreatic_islet	0.16	Nonsignificant	1.00	1.10	Other	52	132
74	ADIPO.adipocyte	0.15	Nonsignificant	—	—	Other	20	62
75	FIB.skin_sheath	0.15	Nonsignificant	1.00	0.68	Other	49	118
76	HPC.haematopoietic_progenitor_cell	0.15	Nonsignificant	—	—	Other	211	370
77	EC.heart_remodeling	0.14	Nonsignificant	1.00	0.00	Other	569	1,594
78	B.memory	0.14	Nonsignificant	1.00	0.62	Other	442	882
79	EPI.renal_intercalated_cell_type_A	0.13	Nonsignificant	1.00	0.80	Other	67	142
80	EPI.tracheal_submucosal_gland	0.11	Nonsignificant	—	0.33	Other	0	0
81	CHOND.chondrocyte	0.09	Nonsignificant	—	—	Other	519	730
82	EPI.intrahepatic_cholangiocyte_defense	0.08	Nonsignificant	—	0.00	Other	8	13
83	EPI.tracheal_suprabasal	0.07	Nonsignificant	1.00	0.72	Other	29	56
84	EPI.alveolar_type_1	0.07	Nonsignificant	1.00	0.70	Other	26	101
85	FIB.skin_papillary	0.06	Nonsignificant	—	0.00	Other	0	0
86	EPI.ileal_enterocyte_crypt	0.06	Nonsignificant	1.00	0.66	Other	67	113
87	EPI.salivary_duct_ion_transport	0.06	Nonsignificant	1.00	0.67	Other	5	11
88	EPI.ileal_bile_transport	0.06	Nonsignificant	1.00	0.71	Other	61	93
89	HEP.canalicular_transport	0.06	Nonsignificant	6.14e-06	1.24	Other	1,290	3,434
90	NEU.INH_VIP	0.05	Nonsignificant	0.52	1.08	Other	241	366
91	FIB.skin_tenogenic	0.05	Nonsignificant	—	0.00	Other	108	227
92	SCHWN.schwann_cell	0.04	Nonsignificant	—	—	Other	7	33
93	T.CD4_Tem	0.04	Nonsignificant	1.00	0.97	Other	365	697
94	EPI.thymic_medullary	0.04	Nonsignificant	1.00	0.61	Other	26	133
95	CM.cardiomyocyte	0.04	Nonsignificant	—	—	Other	524	2,032
96	EPI.hepatic_ductular_cholangiocyte	0.04	Nonsignificant	1.00	0.59	Other	83	243
97	NEU.EXC_IT	0.04	Nonsignificant	1.00	1.01	Other	411	192
98	FIB.adventitial	0.04	Nonsignificant	1.00	0.08	Other	268	1,447
99	FIB.skin_neurosecretory	0.04	Nonsignificant	—	0.00	Other	0	0
100	EPI.pancreatic_ductal_perivascular	0.04	Nonsignificant	1.00	0.58	Other	4	30
101	EPI.gastric_foveolar	0.04	Nonsignificant	—	0.00	Other	0	0
102	T.CD4_Th2	0.04	Nonsignificant	—	0.96	Other	1	2
103	HEP.acute_phase	0.04	Nonsignificant	1.00	0.96	Other	1,441	3,641
104	EPI.colonic_enteroendocrine	0.03	Nonsignificant	—	0.00	Other	1	1
105	T.CD8_Trm	0.03	Nonsignificant	1.00	0.89	Other	211	346
106	MUSC.muscle_stem_cell	0.03	Nonsignificant	—	—	Other	4	18
107	T.CD8_transitional	0.03	Nonsignificant	1.00	0.94	Other	497	932
108	EPI.renal_proximal_tubule	0.02	Nonsignificant	1.00	0.46	Other	525	806
109	T.CD8_Tem	0.02	Nonsignificant	4.72e-20	1.19	Other	1,083	1,857
110	B.germinal_center	0.02	Nonsignificant	1.00	0.14	Other	233	655
111	EPI.ileal_goblet	0.02	Nonsignificant	1.00	0.51	Other	181	432
112	EPI.renal_immature_ureteric_bud	0.02	Nonsignificant	1.00	0.48	Other	217	569
113	T.CD4_Tcm	0.02	Nonsignificant	1.00	0.84	Other	494	988
114	EPI.esophageal_basal	0.02	Nonsignificant	1.00	0.48	Other	4	10
115	EPI.extrahepatic_cholangiocyte	0.02	Nonsignificant	—	0.00	Other	37	71
116	EPI.skin_keratinocyte_proliferating	0.02	Nonsignificant	1.00	0.77	Other	47	76
117	EPI.salivary_mucous_acinar	0.01	Nonsignificant	1.00	0.42	Other	639	1,189
118	ILC2.innate_lymphoid_cell_2	0.01	Nonsignificant	—	—	Other	2	0
119	GRNLSA.granulosa_cell	0.01	Nonsignificant	—	—	Other	257	0
120	EPI.esophageal_suprabasal	0.01	Nonsignificant	1.00	0.44	Other	158	404
121	ASTRO.astrocyte	0.01	Nonsignificant	—	—	Other	228	1,111
122	EPI.skin_keratinocyte_basal	9.82e-03	Nonsignificant	—	0.00	Other	13	26
123	T.MAIT	9.78e-03	Nonsignificant	1.00	0.69	Other	469	855
124	HEP.periportal_metabolic	9.72e-03	Nonsignificant	1.00	0.44	Other	1,750	4,427
125	MEL.melanocyte	8.64e-03	Nonsignificant	—	—	Other	79	242
126	T.CD4_naive	7.99e-03	Nonsignificant	1.00	0.64	Other	399	866
127	EPI.renal_principal_cell	7.96e-03	Nonsignificant	1.00	0.34	Other	207	403
128	EPI.lung_multiciliated	7.63e-03	Nonsignificant	1.00	0.40	Other	16	49
129	T.CD8_naive	7.58e-03	Nonsignificant	1.00	0.70	Other	317	708
130	EPI.pancreatic_ductal_mucinous	6.45e-03	Nonsignificant	1.00	0.32	Other	219	430
131	T.CD4_Th17	4.23e-03	Nonsignificant	1.00	0.78	Other	421	794
132	T.CD8_Tcm	3.84e-03	Nonsignificant	1.00	0.71	Other	460	926
133	EPI.pancreatic_ductal_progenitor	3.53e-03	Nonsignificant	1.00	0.30	Other	234	873
134	EPI.intrahepatic_cholangiocyte_transport	2.85e-03	Nonsignificant	—	0.00	Other	12	42
135	NEU.INH_LAMP5	2.68e-03	Nonsignificant	1.00	0.79	Other	263	532
136	NK.natural_killer_cell	2.68e-03	Nonsignificant	—	—	Other	1,204	2,045
137	IPSC.induced_pluripotent_stem_cell	2.31e-03	Nonsignificant	—	—	Other	0	0
138	NEU.EXC_SYT2	1.76e-03	Nonsignificant	—	0.00	Other	40	77
139	SKM.type_2_fast	1.57e-03	Nonsignificant	1.93e-05	1.11	Other	972	2,639
140	OLG.oligodendrocyte	1.18e-03	Nonsignificant	—	—	Other	384	1,397
141	EPI.skin_follicular_keratinizing	1.05e-03	Nonsignificant	1.00	0.19	Other	30	81
142	EPI.salivary_myoepithelial	9.20e-04	Nonsignificant	1.00	0.11	Other	191	714
143	NEU.INH_PVALB	8.47e-04	Nonsignificant	1.00	0.55	Other	193	183
144	EPI.skin_appendage_keratinocyte	6.50e-04	Nonsignificant	1.00	0.10	Other	87	222
145	EPI.skin_hair_follicle_companion	6.35e-04	Nonsignificant	—	0.00	Other	8	12
146	T.gamma_delta	6.33e-04	Nonsignificant	1.00	0.57	Other	588	1,078
147	EPI.thymic_cortical	5.72e-04	Nonsignificant	1.00	0.33	Other	442	824
148	T.CD4_cytotoxic	3.68e-04	Nonsignificant	1.00	0.46	Other	855	1,493
149	NEU.EXC_CT	3.06e-04	Nonsignificant	1.00	0.43	Other	362	384
150	EPI.skin_interfollicular_spinous	7.25e-05	Nonsignificant	1.00	0.01	Other	260	563
151	NEU.EXC_NTNG1	4.05e-05	Nonsignificant	—	0.00	Other	0	0
152	SKM.type_1_slow	9.24e-06	Nonsignificant	1.00	0.31	Other	923	2,478

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MAC.resident_repair.stress_iron	46.03	Significant	0.51	1.38	Relevant	48	97
2	MAC.resident_repair.ECM_stromal_crosstalk	43.91	Significant	0.51	1.34	Specific	95	158
3	MAC.LAM.antimicrobial	42.17	Significant	7.59e-03	2.14	—	389	93
4	MAC.kupffer.metabolic	41.98	Significant	—	1.39	—	25	36
5	MAC.resident_repair.chemokine_angiocrine	40.94	Significant	0.91	0.94	Relevant	87	138
6	MAC.LAM.lipid_phagocytosis	39.92	Significant	0.03	1.81	—	369	328
7	MAC.LAM.perivascular_angiocrine	38.57	Significant	—	0.45	—	53	138
8	MAC.resident_repair.antigen_presenting	37.73	Significant	0.97	0.26	—	244	113
9	MAC.resident_cardiac.inflammatory_reparative	35.83	Significant	0.05	2.04	Specific	31	96
10	MAC.MDM.complement_resolving	33.62	Significant	0.35	1.52	Relevant	440	860
11	MAC.resident_repair.lipid_phagocytic	32.33	Significant	0.97	0.60	Relevant	228	604
12	MAC.LAM.inflammatory_APC	31.63	Significant	1.00	0.27	—	872	165
13	MAC.LAM.anti_inflammatory	31.43	Significant	0.91	0.75	Relevant	86	132
14	MAC.resident_cardiac.phagocytic_homeostasis	30.67	Significant	0.36	1.20	Specific	564	1,221
15	MAC.LAM.lipid_opsonization	29.82	Significant	0.73	1.07	—	45	14
16	MAC.proliferating.stress	28.55	Significant	—	0.25	Relevant	87	136
17	MG.baseline	27.08	Significant	0.17	1.57	—	16	5
18	MAC.MDM.LAM_like	27.01	Significant	0.98	0.90	Relevant	12	14
19	MAC.resident_cardiac.antigen_presenting	24.71	Significant	0.36	1.13	—	52	27
20	MAC.MDM.inflammatory_phagocytic	24.69	Significant	0.98	0.62	—	199	52
21	MAC.resident_iron.heme_recycling	23.31	Significant	—	0.95	—	30	37
22	MAC.kupffer.monocyte_like	22.71	Significant	—	0.59	—	0	0
23	MAC.proliferating.DNA_replication	22.54	Significant	0.89	0.50	Relevant	3	6
24	MAC.MDM.APC_dendritic	21.87	Significant	0.98	0.23	—	48	15
25	DC.cDC2.proliferative	21.22	Significant	—	0.46	Relevant	39	71
26	MG.expanding	20.54	Significant	0.64	1.07	—	2	1
27	MAC.kupffer.inflammatory	18.40	Significant	—	0.14	—	7	4
28	MAC.microglia_like.inflammatory_chemokine	17.09	Significant	—	0.61	Relevant	20	32
29	MAC.resident_iron.APC_iron_sensing	16.67	Significant	0.74	1.22	—	211	114
30	MG.phagocytic_APC	15.31	Significant	0.99	0.11	—	25	8
31	MAC.resident_iron.heme_catabolism	14.48	Significant	0.94	0.74	—	30	51
32	MONO.CD14.repair_M2_like	14.18	Significant	0.27	1.46	Relevant	550	1,495
33	MAC.microglia_like.phagocytic_redox	14.06	Significant	—	0.00	—	0	0
34	MONO.CD14.baseline	13.79	Significant	3.19e-06	1.82	—	2,268	76
35	MONO.CD14.remodeling	13.04	Significant	1.00	0.95	—	2,373	295
36	DC.cDC2.lipid_metabolic	12.35	Significant	—	0.49	Relevant	0	0
37	DC.cDC2.monocyte_like	11.84	Significant	0.03	1.61	—	1,285	791
38	EC.lymphatic.scavenger	10.88	Significant	0.20	1.59	Relevant	203	257
39	DC.cDC2.pro_inflammatory	10.53	Significant	0.96	0.86	—	3	5
40	MAC.resident_iron.redox_metabolic	10.35	Significant	0.94	0.42	—	4	4
41	MAC.alveolar.capillary_interacting	10.20	Significant	0.05	2.06	Relevant	113	181
42	DC.cDC2.tolerogenic_regulatory	9.85	Significant	0.96	0.98	—	44	4
43	MONO.CD14.inflammatory	9.80	Significant	1.00	0.95	—	92	134
44	MAC.alveolar.inflammatory	9.68	Significant	0.05	1.99	Relevant	208	312
45	EC.lymphatic.tip_migratory	9.43	Significant	0.22	1.47	Relevant	23	37
46	MAC.kupffer.fibrogenic	9.12	Significant	—	0.00	Relevant	0	0
47	MONO.CD14.APC_like	9.05	Significant	1.00	0.11	Relevant	1,686	2,493
48	MAC.alveolar.lipid_autophagy	8.67	Significant	—	0.00	Relevant	35	44
49	DC.cDC2.migratory	8.64	Significant	0.67	1.17	—	185	39
50	MONO.CD16.hepatic_mac_like	8.36	Significant	0.03	1.23	Other	803	117
51	MAC.alveolar.biosynthetic_sterol_heme	7.99	Significant	0.99	0.58	—	347	40
52	MAC.kupffer.tolerogenic	7.67	Significant	—	0.00	—	45	49
53	EC.lymphatic.activated	7.61	Significant	0.78	0.71	Relevant	47	73
54	MONO.CD14.platelet_bound	7.42	Significant	1.00	0.06	—	964	176
55	EC.lymphatic.baseline	7.37	Significant	0.78	0.71	Relevant	38	72
56	MAC.alveolar.scavenging_endocytic	7.26	Significant	—	0.00	Relevant	140	283
57	MAC.microglia_like.patrolling_adhesive	7.14	Significant	—	0.00	—	0	0
58	EC.venous.remodeling_stalk	7.05	Significant	0.65	1.40	Relevant	559	566
59	FIB.lung_alveolar.mito_secretory	6.64	Significant	—	0.48	—	0	0
60	EC.venous.adipose_lipid	6.59	Significant	0.88	1.05	Relevant	254	476
61	DC.cDC2.antiviral	6.57	Significant	0.96	0.66	Other	100	37
62	MAC.alveolar.stress_metabolic	6.49	Significant	0.99	0.03	Relevant	116	148
63	MAC.kupffer.stress	5.85	Significant	0.91	0.37	—	9	3
64	EC.capillary.postcap_venule	5.56	Significant	0.14	1.37	Other	355	261
65	EC.venous.baseline	5.50	Significant	0.88	1.05	Other	346	807
66	EC.venous.activated	5.33	Nominal	0.98	0.91	Other	247	752
67	EPI.renal_distal_tubule.ciliated_remodelling	4.92	Nominal	—	1.04	Other	0	0
68	EC.capillary.migratory	4.72	Nominal	0.14	1.37	Other	181	509
69	EC.venous.quiescent_homeostatic	4.67	Nominal	0.98	0.66	Other	456	360
70	FIB.lung_alveolar.stress_interacting	4.58	Nominal	—	0.00	Other	0	0
71	MAC.resident_iron.stress_tolerogenic	4.42	Nominal	—	0.00	Other	0	0
72	GRANU.neutrophil.tissue_patrolling	4.27	Nominal	—	1.28	Other	0	0
73	EC.capillary.stress	4.08	Nominal	0.79	1.05	Other	44	36
74	DC.cDC2.adhesion_signaling	4.04	Nominal	0.96	0.64	Other	35	9
75	EC.capillary.angiocrine	3.97	Nominal	0.79	1.00	Other	250	630
76	EPI.renal_distal_tubule.repair	3.84	Nominal	—	0.46	Other	34	102
77	EC.capillary.baseline	3.69	Nominal	0.79	1.00	Other	246	560
78	EC.liver_sinusoidal.prostanoid	3.09	Nominal	—	1.27	Other	11	64
79	EC.venous.cardiac_structural	3.07	Nominal	0.98	0.28	Other	102	229
80	EC.arterial.elastic	3.01	Nominal	0.85	1.05	Other	22	45
81	GRANU.neutrophil.antiviral_endotoxin	2.88	Nonsignificant	—	0.00	Other	0	0
82	GRANU.neutrophil.primed_degranulation	2.88	Nonsignificant	—	0.00	Other	0	0
83	THYMO.DP_early_stress	2.73	Nonsignificant	—	2.74	Other	0	0
84	EC.arterial.metabolic	2.71	Nonsignificant	0.54	1.27	Other	195	159
85	MONO.CD14.cord_tolerance	2.65	Nonsignificant	1.00	4.67e-03	Other	864	753
86	EC.arterial.inflammatory	2.59	Nonsignificant	0.54	1.31	Other	63	50
87	EC.arterial.arteriole_interface	2.55	Nonsignificant	0.74	1.15	Other	31	12
88	EC.arterial.homeostatic	2.40	Nonsignificant	0.85	0.98	Other	24	3
89	EC.capillary.inflammatory	2.28	Nonsignificant	0.99	0.66	Other	27	51
90	FIB.neurolectin_mucosa.inflammatory	2.22	Nonsignificant	0.37	1.14	Other	52	110
91	EC.arterial.mito_contact	2.20	Nonsignificant	0.93	0.84	Other	14	5
92	EC.capillary.activated	2.18	Nonsignificant	0.99	0.55	Other	2	5
93	FIB.neurolectin_mucosa.axon_responsive	2.17	Nonsignificant	0.37	1.37	Other	10	10
94	EPI.renal_distal_tubule.ion_transport	2.16	Nonsignificant	—	0.13	Other	0	0
95	DC.mig.baseline	2.13	Nonsignificant	—	0.00	Other	1	0
96	ASPC.activated	2.09	Nonsignificant	1.73e-03	1.65	Other	164	162
97	EC.capillary.angiogenic_tip	2.08	Nonsignificant	0.99	0.48	Other	186	218
98	PC.IgG_systemic.metabolic	2.06	Nonsignificant	0.39	1.39	Other	46	63
99	FIB.neurolectin_mucosa.nerve_interface	2.06	Nonsignificant	—	0.09	Other	4	0
100	FIB.interstitial.mesenchymal_APC	2.03	Nonsignificant	9.44e-03	1.52	Other	81	33
101	EPI.salivary_duct_excretory.stress	1.93	Nonsignificant	0.13	1.61	Other	33	68
102	EPI.skin_sweat_duct_keratinocyte.barrier	1.85	Nonsignificant	—	1.52	Other	0	0
103	EPI.colonic_tuft.activated	1.83	Nonsignificant	—	0.00	Other	0	0
104	PC.IgA_muocsal.activated	1.78	Nonsignificant	0.04	1.43	Other	17	8
105	EPI.cervical_suprabasal.secretory_vesicle	1.77	Nonsignificant	—	0.00	Other	0	0
106	ASPC.inflammatory	1.77	Nonsignificant	0.43	1.23	Other	21	61
107	DC.cDC1.activated	1.75	Nonsignificant	—	0.52	Other	0	0
108	EC.arterial.angiogenic_tip	1.75	Nonsignificant	—	0.00	Other	30	37
109	DC.cDC1.homeostatic_inhibitory	1.74	Nonsignificant	—	0.32	Other	0	0
110	MONO.CD16.inflammatory	1.73	Nonsignificant	0.55	1.04	Other	1,640	168
111	T.CD4_Trm.metal_stress	1.72	Nonsignificant	0.24	1.43	Other	34	58
112	FIB.interstitial.lipid_matrix	1.71	Nonsignificant	0.52	1.07	Other	258	191
113	EPI.renal_distal_tubule.stress	1.69	Nonsignificant	—	0.00	Other	0	0
114	ASPC.stem_like_progenitor	1.68	Nonsignificant	0.21	1.37	Other	300	842
115	EPI.colonic_tuft.homeostatic	1.68	Nonsignificant	—	0.00	Other	0	0
116	EPI.ectocervical_granular.immune_interact	1.67	Nonsignificant	—	1.15	Other	0	0
117	EPI.colonocyte.crypt_progenitor	1.67	Nonsignificant	0.08	1.59	Other	115	265
118	EC.arterial.arteriole_gas_exchange	1.64	Nonsignificant	0.98	0.59	Other	238	131
119	MONO.CD16.platelet_bound	1.64	Nonsignificant	0.55	1.15	Other	372	508
120	FIB.transitioning.matrix_stress	1.63	Nonsignificant	—	0.18	Other	47	138
121	EC.liver_sinusoidal.inflammatory	1.63	Nonsignificant	—	0.48	Other	223	154
122	FIB.transitioning.ISG_primed_interface	1.63	Nonsignificant	—	0.56	Other	17	80
123	EPI.colonocyte.ionocyte_BEST4	1.58	Nonsignificant	0.55	1.27	Other	103	188
124	PC.IgA_muocsal.plasmablast	1.57	Nonsignificant	0.96	0.82	Other	5	4
125	FIB.barrier_secretory.homeostasis	1.56	Nonsignificant	—	0.00	Other	0	0
126	EPI.salivary_serous_acinar.quiescent	1.55	Nonsignificant	8.25e-03	1.41	Other	178	493
127	ASPC.baseline	1.53	Nonsignificant	0.18	1.23	Other	363	170
128	OPC.homeostatic	1.52	Nonsignificant	0.16	1.66	Other	394	160
129	DC.cDC1.cross_presenting	1.52	Nonsignificant	—	0.17	Other	0	0
130	EC.arterial.ion_pump	1.49	Nonsignificant	0.98	0.53	Other	3	2
131	EPI.ectocervical_granular.inflammatory	1.45	Nonsignificant	—	0.32	Other	0	0
132	EPI.lung_club_secretory.inflammatory	1.44	Nonsignificant	—	1.47	Other	0	0
133	OPC.proliferative_immune_interact	1.42	Nonsignificant	0.37	1.30	Other	180	373
134	EPI.colonocyte.junction_remodeling	1.40	Nonsignificant	0.58	1.12	Other	218	305
135	FIB.interstitial.stress_secretory	1.39	Nonsignificant	0.52	1.18	Other	92	56
136	PC.IgA_muocsal.migratory	1.37	Nonsignificant	0.96	0.95	Other	4	1
137	MONO.CD16.baseline	1.35	Nonsignificant	1.00	0.89	Other	50	1
138	FIB.interstitial.immune_interact	1.33	Nonsignificant	0.64	0.99	Other	12	1
139	ASPC.preadipocyte_lipid_primed	1.33	Nonsignificant	0.64	1.05	Other	331	129
140	FIB.interstitial.mesenchymal_regulator	1.31	Nonsignificant	0.52	1.08	Other	4	4
141	PC.IgA_muocsal.baseline	1.30	Nonsignificant	0.98	0.56	Other	3	5
142	EC.liver_sinusoidal.remodeling_lipotoxicity	1.20	Nonsignificant	—	0.69	Other	90	58
143	PC.IgG_systemic.secretory	1.20	Nonsignificant	0.84	0.65	Other	0	0
144	THYMO.SP_CD8_naive_stress	1.20	Nonsignificant	0.36	1.31	Other	1	1
145	EPI.salivary_intercalated_defense.inflammatory	1.19	Nonsignificant	0.39	1.29	Other	152	360
146	DC.cDC1.proliferative	1.17	Nonsignificant	—	0.00	Other	0	0
147	FIB.neurolectin_mucosa.remodeling_repair	1.15	Nonsignificant	—	0.00	Other	4	2
148	T.CD4_Tfh.suppression_exhaustion	1.13	Nonsignificant	0.43	1.43	Other	0	2
149	DC.pDC.poised_migratory	1.13	Nonsignificant	0.12	1.31	Other	54	95
150	ASPC.secretory	1.13	Nonsignificant	1.00	0.56	Other	76	5
151	PC.IgG_systemic.stress	1.12	Nonsignificant	—	0.00	Other	1	5
152	EPI.renal_intercalated_cell_type_B.baseline	1.11	Nonsignificant	—	0.00	Other	3	1
153	OPC.premyelinating	1.09	Nonsignificant	0.98	0.24	Other	185	12
154	EPI.cervical_suprabasal.inflammatory_repair	1.08	Nonsignificant	—	0.00	Other	0	0
155	T.CD8_transitional.stress	1.04	Nonsignificant	—	1.64	Other	24	34
156	FIB.transitioning.secretory_procollagen	1.04	Nonsignificant	—	0.00	Other	0	0
157	FIB.adventitial.activated_remodelling	1.03	Nonsignificant	—	1.67	Other	141	319
158	PC.IgG_systemic.interacting	1.03	Nonsignificant	0.84	0.63	Other	0	0
159	T.CD4_Treg.Tr1_like	1.02	Nonsignificant	—	0.79	Other	8	8
160	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.99	Nonsignificant	—	1.13	Other	0	0
161	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.99	Nonsignificant	0.39	1.10	Other	11	22
162	EPI.salivary_duct_excretory.baseline	0.98	Nonsignificant	1.00	0.00	Other	23	57
163	FIB.barrier_secretory.remodeling	0.98	Nonsignificant	—	0.00	Other	0	0
164	THYMO.SP_CD8_naive	0.97	Nonsignificant	5.42e-03	1.61	Other	297	177
165	THYMO.DP_early	0.92	Nonsignificant	0.32	1.26	Other	326	313
166	DC.cDC1.baseline	0.89	Nonsignificant	—	0.00	Other	0	0
167	EPI.alveolar_type_2.stress_response	0.86	Nonsignificant	2.80e-06	1.87	Other	675	1,562
168	THYMO.SP_CD8_transitional	0.86	Nonsignificant	0.70	1.07	Other	32	75
169	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.85	Nonsignificant	0.47	1.36	Other	2	9
170	EPI.renal_thick_ascending_limb.cation_flux	0.81	Nonsignificant	0.77	1.08	Other	57	95
171	EPI.colonocyte.proximal_transport	0.81	Nonsignificant	1.00	0.30	Other	24	12
172	T.CD4_Treg.APC_interactive	0.79	Nonsignificant	0.03	1.48	Other	118	28
173	FIB.transitioning.motility_remodelling	0.79	Nonsignificant	—	0.00	Other	0	0
174	SMC.activated	0.74	Nonsignificant	0.35	1.09	Other	2	5
175	ASPC.mesothelial_like	0.71	Nonsignificant	0.43	1.33	Other	143	486
176	B.memory.preactivated	0.69	Nonsignificant	3.26e-06	1.61	Other	173	174
177	EPI.pancreatic_acinar.inflammatory_regenerative	0.67	Nonsignificant	0.70	1.07	Other	25	113
178	B.naive.restrained	0.66	Nonsignificant	9.47e-06	1.49	Other	183	353
179	EPI.skin_keratinocyte_progenitor.activated_stress	0.66	Nonsignificant	—	0.38	Other	0	0
180	FIB.suburothelial.urothelial_interface	0.66	Nonsignificant	1.90e-03	2.60	Other	9	8
181	EPI.colonocyte.goblet_interface	0.65	Nonsignificant	—	0.00	Other	11	21
182	FIB.tracheal_subepithelial.baseline	0.63	Nonsignificant	—	0.00	Other	0	0
183	EPI.endocervical_secretory.secretory_translocon	0.63	Nonsignificant	—	0.67	Other	0	0
184	EPI.renal_thick_ascending_limb.barrier_repair	0.62	Nonsignificant	0.77	1.03	Other	141	284
185	B.age_associated.activated	0.61	Nonsignificant	—	0.32	Other	18	22
186	T.CD4_Trm.baseline	0.61	Nonsignificant	0.24	1.24	Other	31	21
187	EC.liver_sinusoidal.hypoxia_metabolic	0.61	Nonsignificant	0.98	0.56	Other	183	107
188	MESO.antiviral	0.60	Nonsignificant	—	0.61	Other	3	8
189	EPI.renal_thick_ascending_limb.remodeling	0.59	Nonsignificant	0.77	1.12	Other	152	92
190	EPI.ectocervical_granular.secretory_apocrine	0.58	Nonsignificant	—	0.00	Other	0	0
191	MESO.activated_stress	0.58	Nonsignificant	—	0.32	Other	0	0
192	FIB.barrier_purinergic.lipid_secretory	0.57	Nonsignificant	—	0.48	Other	0	0
193	EPI.pancreatic_acinar.quiet_dedifferentiation	0.56	Nonsignificant	0.71	1.01	Other	142	171
194	EC.lymphatic.valve	0.56	Nonsignificant	—	0.00	Other	0	0
195	EPI.colonocyte.distal_absorptive	0.55	Nonsignificant	—	0.00	Other	0	0
196	FIB.reticular.stress_metallothionein	0.55	Nonsignificant	—	0.48	Other	3	32
197	EPI.skin_sebaceous_duct_luminal.detox_repair	0.54	Nonsignificant	0.94	0.31	Other	137	94
198	FIB.interstitial.remodeling	0.54	Nonsignificant	1.00	0.12	Other	31	9
199	FIB.reticular.immune_interface	0.52	Nonsignificant	—	0.22	Other	1	6
200	ASPC.niche_keeping_progenitor	0.52	Nonsignificant	1.00	0.26	Other	52	219
201	EPI.endocervical_secretory.squamous_barrier	0.52	Nonsignificant	—	0.00	Other	0	0
202	EPI.pancreatic_ductal_bicarbonate.stress	0.48	Nonsignificant	—	0.69	Other	12	33
203	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.47	Nonsignificant	0.20	1.26	Other	40	191
204	CM.contractile_oxphos	0.47	Nonsignificant	0.05	1.30	Other	6	19
205	T.CD4_transitional.primed_helper_effector	0.47	Nonsignificant	0.48	1.14	Other	19	43
206	FIB.suburothelial.homeostasis_matrix	0.47	Nonsignificant	0.75	0.61	Other	258	921
207	T.CD4_Tfh.canonical_GC_helper	0.46	Nonsignificant	0.91	0.82	Other	1	2
208	FIB.perivascular_interface.vascular_BM_remodelling	0.45	Nonsignificant	—	0.16	Other	0	0
209	PERI.inflammatory	0.45	Nonsignificant	0.06	1.19	Other	40	77
210	FIB.reticular.ECM_builder	0.44	Nonsignificant	—	0.38	Other	0	0
211	EPI.ileal_enterocyte_absorptive.brush_border	0.44	Nonsignificant	0.04	1.84	Other	580	1,717
212	MESO.baseline	0.44	Nonsignificant	0.57	0.98	Other	0	6
213	T.CD4_transitional.tissue_enagement	0.44	Nonsignificant	0.48	1.23	Other	5	11
214	FIB.suburothelial.contractile_myofibroblast	0.43	Nonsignificant	—	0.00	Other	9	0
215	SMC.metabolic	0.43	Nonsignificant	0.35	1.06	Other	14	40
216	EPI.colonocyte.secretory_boost	0.43	Nonsignificant	1.00	0.04	Other	98	91
217	FIB.hepatic_stellate_cell.inflammatory	0.43	Nonsignificant	—	1.15	Other	0	0
218	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.42	Nonsignificant	—	0.62	Other	2	0
219	EPI.alveolar_type_2.baseline_surfactant	0.42	Nonsignificant	1.00	0.72	Other	64	9
220	THYMO.proliferative_G2M	0.42	Nonsignificant	—	0.00	Other	164	413
221	EPI.pancreatic_ductal_bicarbonate.activated	0.41	Nonsignificant	0.92	1.00	Other	10	7
222	HEP.pericentral_lipoprotein.UPR_redox	0.41	Nonsignificant	—	0.67	Other	0	0
223	T.CD4_transitional.primed_cytotoxic	0.40	Nonsignificant	0.81	1.01	Other	28	30
224	EPI.pancreatic_ductal_bicarbonate.baseline	0.40	Nonsignificant	0.20	1.19	Other	11	42
225	EPI.renal_thick_ascending_limb.salt_sensing	0.40	Nonsignificant	0.96	0.82	Other	73	103
226	HEP.pericentral_lipoprotein.ApoB_coagulation	0.40	Nonsignificant	—	0.00	Other	0	0
227	EPI.pancreatic_islet.alpha	0.39	Nonsignificant	—	0.87	Other	152	330
228	FIB.suburothelial.inflammatory_prostanoid	0.39	Nonsignificant	—	0.00	Other	0	0
229	NEU.INH_VIP.develop_niche	0.38	Nonsignificant	—	1.68	Other	0	0
230	T.CD4_Trm.central_like	0.38	Nonsignificant	0.98	0.90	Other	38	31
231	FIB.perivascular_interface.lipid_shuttle	0.38	Nonsignificant	—	0.30	Other	51	170
232	PLAT.adhesion	0.38	Nonsignificant	—	0.48	Other	0	0
233	PERI.baseline	0.37	Nonsignificant	0.22	1.11	Other	39	66
234	THYMO.CD8aa_IELp	0.36	Nonsignificant	—	0.00	Other	1	7
235	T.CD4_Treg.central_naive_like	0.36	Nonsignificant	1.00	0.51	Other	333	45
236	NEU.INH_VIP.cannabinoid	0.36	Nonsignificant	—	1.34	Other	0	0
237	B.age_associated.migratory	0.35	Nonsignificant	0.84	0.61	Other	2	2
238	EPI.salivary_intercalated_defense.basal_EMT	0.35	Nonsignificant	—	0.00	Other	0	0
239	EPI.pancreatic_acinar.baseline	0.35	Nonsignificant	0.70	1.10	Other	274	163
240	T.CD4_Tfh.effector_migratory	0.35	Nonsignificant	0.43	1.32	Other	122	57
241	EC.heart_remodeling.capillary_metabolic	0.35	Nonsignificant	7.83e-03	1.57	Other	54	414
242	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.35	Nonsignificant	—	0.10	Other	29	88
243	B.naive.antigen_presenting_ready	0.34	Nonsignificant	0.40	1.22	Other	48	73
244	HPC.LMPP	0.34	Nonsignificant	0.51	1.13	Other	65	31
245	FIB.hepatic_stellate_cell.fibrogenic	0.34	Nonsignificant	—	0.00	Other	0	0
246	EC.liver_sinusoidal.secretory_lipoprotein	0.34	Nonsignificant	0.98	0.21	Other	120	70
247	EPI.skin_hair_follicle_bulge.quiescent	0.33	Nonsignificant	0.31	1.21	Other	56	69
248	FIB.perivascular_interface.vasomotor_tone	0.33	Nonsignificant	—	0.00	Other	0	0
249	THYMO.SP_CD4_naive	0.33	Nonsignificant	1.00	0.32	Other	65	75
250	ASPC.adipocyte_capillary_interface	0.32	Nonsignificant	1.00	0.12	Other	21	54
251	EC.liver_sinusoidal.stress	0.31	Nonsignificant	—	0.00	Other	413	158
252	EPI.ileal_enterocyte_absorptive.villus_tip	0.31	Nonsignificant	0.72	0.75	Other	4	3
253	GRANU.MAST.resting_granule	0.31	Nonsignificant	—	0.76	Other	0	0
254	T.CD4_Trm.cytotoxic_effector	0.31	Nonsignificant	0.98	0.75	Other	118	77
255	B.age_associated.naive_transitional	0.30	Nonsignificant	—	1.11e-16	Other	0	0
256	DC.pDC.immature_metabolic	0.30	Nonsignificant	0.95	0.91	Other	78	124
257	ADIPO.thermogenic	0.29	Nonsignificant	—	0.62	Other	0	0
258	FIB.barrier_purinergic.stress_GF_binding	0.29	Nonsignificant	—	0.00	Other	0	0
259	T.CD4_Trm.activated	0.29	Nonsignificant	0.98	1.06	Other	32	26
260	HPC.MPP_activated	0.28	Nonsignificant	—	0.76	Other	0	0
261	SMC.contractile	0.28	Nonsignificant	0.12	1.27	Other	80	588
262	B.naive.proteostasis	0.28	Nonsignificant	1.00	1.08	Other	49	69
263	EPI.tracheal_basal.homeostatic_progenitor	0.27	Nonsignificant	0.38	1.13	Other	285	74
264	B.naive.activated	0.26	Nonsignificant	1.00	0.90	Other	77	127
265	PERI.angiocrine	0.26	Nonsignificant	1.00	0.93	Other	93	102
266	FIB.reticular.stromal_niche	0.26	Nonsignificant	0.90	0.59	Other	0	0
267	EPI.tracheal_basal.activated_stress	0.26	Nonsignificant	0.22	1.56	Other	32	0
268	GRANU.MAST.activated_acute	0.24	Nonsignificant	—	0.44	Other	0	0
269	EPI.lung_club_secretory.ciliogenesis_primed	0.23	Nonsignificant	—	0.79	Other	0	0
270	EC.heart_remodeling.angiocrine	0.23	Nonsignificant	3.10e-03	1.38	Other	182	525
271	T.CD4_Treg.tissue_effector	0.22	Nonsignificant	1.00	0.33	Other	16	13
272	T.CD4_transitional.baseline	0.22	Nonsignificant	0.94	0.77	Other	59	97
273	T.CD4_transitional.APC_interacting	0.20	Nonsignificant	0.94	0.72	Other	10	14
274	HEP.acute_phase.hypoxia_lipid	0.20	Nonsignificant	—	1.90	Other	0	0
275	THYMO.DN_preTCR	0.20	Nonsignificant	1.00	0.17	Other	41	71
276	FIB.skin_sheath.stress_chaperone	0.20	Nonsignificant	—	0.44	Other	0	0
277	FIB.hepatic_stellate_cell.contractile	0.20	Nonsignificant	—	0.00	Other	0	0
278	EPI.pancreatic_acinar.stress	0.19	Nonsignificant	0.70	1.08	Other	28	28
279	CHOND.activated_fibro_like	0.19	Nonsignificant	1.07e-03	1.29	Other	531	188
280	T.CD4_Tfh.precursor_migratory	0.19	Nonsignificant	0.98	0.43	Other	72	27
281	DC.pDC.baseline	0.18	Nonsignificant	0.95	0.65	Other	88	123
282	FIB.skin_sheath.ECM_immune	0.18	Nonsignificant	—	0.35	Other	0	0
283	MESO.activated_migratory	0.18	Nonsignificant	—	0.00	Other	0	0
284	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.17	Nonsignificant	—	0.73	Other	0	0
285	CM.translation_boost_RPS	0.17	Nonsignificant	0.79	1.16	Other	69	16
286	ASPC.proliferative	0.17	Nonsignificant	1.00	0.59	Other	33	85
287	CHOND.remodeling	0.17	Nonsignificant	—	0.96	Other	5	0
288	B.naive.metabolic	0.16	Nonsignificant	1.00	0.70	Other	50	79
289	HPC.GMP_inflammatory	0.16	Nonsignificant	0.51	1.13	Other	20	10
290	T.CD4_Tcm.APC_mimicry	0.16	Nonsignificant	0.96	1.25	Other	54	43
291	T.CD4_Trm.stress_adaptive	0.16	Nonsignificant	0.98	0.62	Other	8	22
292	EPI.alveolar_type_1.activated	0.16	Nonsignificant	—	1.64	Other	0	0
293	EPI.ectocervical_granular.proliferative_basal	0.16	Nonsignificant	—	0.00	Other	0	0
294	EC.heart_remodeling.translation_boost	0.16	Nonsignificant	—	0.48	Other	0	0
295	B.naive.remodeling	0.15	Nonsignificant	1.00	0.59	Other	135	230
296	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.15	Nonsignificant	—	1.22	Other	0	0
297	EPI.renal_intercalated_cell_type_A.acid_secretion	0.15	Nonsignificant	0.16	1.34	Other	12	6
298	NEU.INH_VIP.LAMP5_hybrid	0.14	Nonsignificant	—	1.24	Other	1	9
299	ADIPO.hypoxia_remodelling	0.14	Nonsignificant	—	0.00	Other	29	105
300	SCHWN.reactive_inflammatory	0.13	Nonsignificant	—	1.27	Other	0	0
301	B.naive.baseline	0.13	Nonsignificant	1.00	0.68	Other	10	13
302	ADIPO.immature	0.13	Nonsignificant	—	0.44	Other	24	40
303	B.naive.purinergic	0.13	Nonsignificant	1.00	0.50	Other	384	820
304	NEU.EXC_IT.guidance	0.13	Nonsignificant	1.00	1.09	Other	274	63
305	B.memory.activated	0.13	Nonsignificant	0.79	1.09	Other	105	29
306	T.CD4_Trm.helper_like	0.12	Nonsignificant	0.98	0.47	Other	84	147
307	EPI.tracheal_submucosal_gland.acinar_serous	0.12	Nonsignificant	—	0.00	Other	0	0
308	B.memory.migratory	0.12	Nonsignificant	0.97	0.98	Other	123	208
309	EPI.ileal_enterocyte_crypt.bile_transport	0.12	Nonsignificant	0.41	1.41	Other	2	0
310	EPI.skin_sebaceous_duct_luminal.immune_interface	0.11	Nonsignificant	—	0.00	Other	0	0
311	HEP.canalicular_transport.pericentral_like_hypoxia	0.11	Nonsignificant	0.22	1.17	Other	326	8
312	T.CD4_Tem.transitional_CM	0.11	Nonsignificant	0.47	1.09	Other	31	20
313	GRANU.MAST.activated_repair	0.10	Nonsignificant	—	0.00	Other	0	1
314	EPI.lung_club_secretory.ciliogenesis_axoneme	0.10	Nonsignificant	—	0.00	Other	0	0
315	EPI.tracheal_submucosal_gland.ductal_luminal	0.10	Nonsignificant	—	0.00	Other	0	0
316	B.naive.receptor_recycle	0.10	Nonsignificant	1.00	0.44	Other	51	0
317	EC.heart_remodeling.remodeling_stalk	0.10	Nonsignificant	0.94	0.98	Other	33	111
318	FIB.adventitial.inflammatory_activated	0.09	Nonsignificant	0.86	1.11	Other	100	473
319	HPC.GMP_granulocytic	0.09	Nonsignificant	—	0.00	Other	3	3
320	EC.heart_remodeling.remodeling_secretory	0.09	Nonsignificant	0.94	0.86	Other	605	1,341
321	HPC.CLP_B_primed	0.08	Nonsignificant	—	0.53	Other	0	0
322	HEP.canalicular_transport.baseline	0.08	Nonsignificant	0.69	1.09	Other	199	477
323	HEP.canalicular_transport.inflammatory	0.08	Nonsignificant	3.28e-04	1.35	Other	1,335	194
324	EPI.tracheal_suprabasal.transitional_wound	0.08	Nonsignificant	—	0.00	Other	16	1
325	EPI.ileal_enterocyte_crypt.villus_transition	0.08	Nonsignificant	—	0.52	Other	7	10
326	T.CD4_Tem.inflammatory	0.08	Nonsignificant	0.47	1.06	Other	28	6
327	FIB.skin_sheath.neuro_vascular_interface	0.08	Nonsignificant	—	0.00	Other	0	0
328	EPI.salivary_serous_acinar.secretory_active	0.07	Nonsignificant	1.00	0.10	Other	242	69
329	B.memory.baseline	0.07	Nonsignificant	1.00	0.38	Other	472	99
330	EPI.lung_club_secretory.canonical_surfactant	0.07	Nonsignificant	—	0.00	Other	74	104
331	NEU.INH_VIP.matrix	0.07	Nonsignificant	—	0.77	Other	24	77
332	EPI.ileal_enterocyte_crypt.secretory_precursor	0.07	Nonsignificant	—	0.28	Other	0	0
333	EPI.skin_keratinocyte_proliferating.detox_repair	0.06	Nonsignificant	—	1.13	Other	0	0
334	EPI.ileal_goblet.immature	0.06	Nonsignificant	—	0.43	Other	0	0
335	FIB.skin_papillary.baseline	0.06	Nonsignificant	—	0.00	Other	0	0
336	EPI.tracheal_suprabasal.secretory_immune	0.06	Nonsignificant	—	0.00	Other	0	0
337	HEP.periportal_metabolic.apolipoprotein_secretory	0.06	Nonsignificant	0.10	1.50	Other	43	110
338	EC.heart_remodeling.activated_acute	0.06	Nonsignificant	0.94	0.84	Other	102	186
339	SCHWN.translation_boost	0.06	Nonsignificant	—	0.30	Other	8	1
340	EPI.alveolar_type_2.injury_primed	0.06	Nonsignificant	1.00	0.00	Other	434	245
341	EPI.salivary_duct_ion_transport.baseline	0.06	Nonsignificant	—	—	Other	0	0
342	EPI.ileal_bile_transport.absorptive_xenobiotic	0.06	Nonsignificant	0.25	1.46	Other	11	12
343	MESO.secretory_structural	0.06	Nonsignificant	—	0.00	Other	0	0
344	EC.heart_remodeling.perivascular	0.06	Nonsignificant	0.96	0.60	Other	124	408
345	T.CD8_Tem.stress_adapted	0.06	Nonsignificant	0.10	1.05	Other	607	520
346	GRNLSA.chemokine_mechanosensory	0.06	Nonsignificant	0.67	1.18	Other	1	0
347	EPI.thymic_medullary.stress_APC	0.05	Nonsignificant	0.86	1.03	Other	2	4
348	EPI.alveolar_type_1.baseline	0.05	Nonsignificant	1.00	0.00	Other	8	0
349	CM.translation_boost_RPL	0.05	Nonsignificant	0.79	1.06	Other	129	1
350	FIB.skin_tenogenic.baseline	0.05	Nonsignificant	—	0.00	Other	0	2
351	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.05	Nonsignificant	1.00	0.70	Other	14	32
352	EPI.thymic_medullary.hormone_xeno_barrier	0.05	Nonsignificant	—	0.68	Other	0	8
353	B.memory.pDC_imprint	0.05	Nonsignificant	1.00	0.51	Other	157	103
354	EPI.renal_intercalated_cell_type_A.PC_transitional	0.05	Nonsignificant	—	0.00	Other	203	407
355	HPC.MPP_IEG	0.05	Nonsignificant	1.00	0.78	Other	45	46
356	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.05	Nonsignificant	—	0.30	Other	0	0
357	EPI.ileal_enterocyte_crypt.baseline	0.05	Nonsignificant	0.52	1.07	Other	11	6
358	ASPC.signal_integrator	0.05	Nonsignificant	—	0.00	Other	0	0
359	HEP.acute_phase.baseline	0.05	Nonsignificant	0.29	1.16	Other	946	19
360	T.CD8_Tem.early_helper_like	0.05	Nonsignificant	0.47	1.06	Other	445	755
361	MONO.CD16.patrolling	0.05	Nonsignificant	1.00	0.08	Other	797	216
362	MEL.neurotrophic_migratory	0.05	Nonsignificant	—	1.58	Other	0	0
363	EPI.ileal_bile_transport.detox_transcytosis	0.05	Nonsignificant	—	0.00	Other	0	1
364	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.04	Nonsignificant	—	0.00	Other	0	0
365	T.CD8_transitional.Trm_primed	0.04	Nonsignificant	0.53	1.06	Other	108	15
366	T.CD8_Trm.muscosal_Tc17	0.04	Nonsignificant	0.75	1.13	Other	19	38
367	MUSC.early_activation	0.04	Nonsignificant	0.68	1.45	Other	4	32
368	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.04	Nonsignificant	—	0.00	Other	6	9
369	HEP.acute_phase.complement_metabolic	0.04	Nonsignificant	0.29	1.20	Other	1,423	3,464
370	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.04	Nonsignificant	1.00	0.31	Other	322	317
371	THYMO.proliferative_S	0.04	Nonsignificant	1.00	0.00	Other	163	418
372	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.04	Nonsignificant	5.81e-03	1.81	Other	58	89
373	EPI.salivary_serous_acinar.seromucous_like	0.04	Nonsignificant	—	0.12	Other	0	0
374	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.04	Nonsignificant	—	0.97	Other	0	0
375	EPI.pancreatic_acinar.adhesion_remodeling	0.04	Nonsignificant	0.98	0.88	Other	210	784
376	T.CD4_Th2.tissue_adapted	0.04	Nonsignificant	—	0.00	Other	0	0
377	EPI.pancreatic_ductal_perivascular.baseline	0.04	Nonsignificant	0.63	0.92	Other	1	5
378	T.MAIT.stress	0.04	Nonsignificant	—	0.33	Other	0	0
379	EPI.colonic_enteroendocrine.Lcell_peptide	0.04	Nonsignificant	—	0.00	Other	0	0
380	FIB.skin_neurosecretory.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
381	EPI.thymic_medullary.canonical_alarmin	0.04	Nonsignificant	0.86	0.50	Other	8	17
382	EPI.gastric_foveolar.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
383	B.germinal_center.DZ_S_phase	0.04	Nonsignificant	—	0.55	Other	0	0
384	EPI.bile_duct_cholangiocyte.secretory_mucin	0.04	Nonsignificant	—	0.00	Other	7	12
385	CM.baseline	0.04	Nonsignificant	1.00	0.97	Other	393	0
386	NEU.EXC_IT.callosal	0.04	Nonsignificant	1.00	1.01	Other	286	119
387	MUSC.quiescent_reservoir	0.03	Nonsignificant	0.87	1.07	Other	2	8
388	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.03	Nonsignificant	—	0.00	Other	11	69
389	T.CD8_Trm.dendritic_recruiter	0.03	Nonsignificant	0.75	0.90	Other	47	85
390	T.CD4_Th2.precursor	0.03	Nonsignificant	—	0.00	Other	0	0
391	NK.cytokine_lung_immediate_early	0.03	Nonsignificant	0.52	1.11	Other	424	274
392	T.CD8_Trm.homeostatic	0.03	Nonsignificant	0.75	1.02	Other	42	5
393	EPI.ileal_enterocyte_crypt.proliferative_S	0.03	Nonsignificant	0.52	0.94	Other	4	2
394	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.03	Nonsignificant	—	0.73	Other	0	0
395	EPI.ileal_goblet.inflammatory_mucin	0.03	Nonsignificant	0.25	1.35	Other	6	9
396	T.CD8_naive.effector_transition	0.03	Nonsignificant	0.40	1.44	Other	35	62
397	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.03	Nonsignificant	—	0.00	Other	19	54
398	CM.mechano_activated	0.03	Nonsignificant	0.79	1.09	Other	205	134
399	T.CD4_naive.Treg_like	0.03	Nonsignificant	0.83	1.46	Other	121	72
400	T.CD4_Tcm.Tfh_like	0.03	Nonsignificant	0.96	1.11	Other	102	214
401	T.CD8_Trm.cytotoxic	0.03	Nonsignificant	0.75	0.97	Other	165	85
402	T.CD8_Trm.inflammatory	0.03	Nonsignificant	0.75	0.97	Other	124	176
403	NK.cytokine_repair_primed	0.03	Nonsignificant	3.17e-03	1.12	Other	266	11
404	EPI.skin_keratinocyte_basal.spinous_transition	0.03	Nonsignificant	—	0.97	Other	0	0
405	EPI.colonic_enteroendocrine.progenitor	0.03	Nonsignificant	—	0.00	Other	0	0
406	FIB.adventitial.PI16_matrix	0.03	Nonsignificant	1.00	0.96	Other	70	90
407	ASPC.remodeling	0.02	Nonsignificant	1.00	5.67e-03	Other	106	354
408	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.02	Nonsignificant	—	0.03	Other	5	3
409	T.CD8_naive.vesicle_secretory	0.02	Nonsignificant	0.40	1.51	Other	42	0
410	ASTRO.immature_lipid	0.02	Nonsignificant	0.61	1.20	Other	23	113
411	GRNLSA.cholesterol_mevalonate	0.02	Nonsignificant	0.67	1.07	Other	9	4
412	B.germinal_center.LZ_selection	0.02	Nonsignificant	—	0.00	Other	0	0
413	EPI.skin_sweat_duct_keratinocyte.repair	0.02	Nonsignificant	—	0.80	Other	0	0
414	EPI.esophageal_basal.activated_progenitor	0.02	Nonsignificant	0.04	1.52	Other	1	0
415	HEP.canalicular_transport.secretory_ERAD_UPR	0.02	Nonsignificant	1.00	0.77	Other	232	28
416	EPI.renal_immature_ureteric_bud.osmoprotective	0.02	Nonsignificant	0.23	1.30	Other	126	44
417	MUSC.baseline	0.02	Nonsignificant	0.87	0.52	Other	0	0
418	FIB.adventitial.adhesion_lipid	0.02	Nonsignificant	1.00	0.94	Other	58	209
419	T.MAIT.early_activation	0.02	Nonsignificant	0.17	1.50	Other	57	4
420	IPSC.endoderm_primed	0.02	Nonsignificant	0.58	1.18	Other	0	0
421	B.germinal_center.LZ_memory_precursor	0.02	Nonsignificant	—	0.37	Other	0	0
422	MUSC.activated_migratory	0.02	Nonsignificant	0.87	0.81	Other	6	7
423	HEP.acute_phase.stress_secretory	0.02	Nonsignificant	0.99	0.82	Other	26	3
424	CHOND.angiogenic	0.02	Nonsignificant	—	0.18	Other	0	0
425	CHOND.articular_collagen	0.02	Nonsignificant	1.00	0.44	Other	551	266
426	EPI.renal_principal_cell.canonical_vasopressin	0.02	Nonsignificant	0.16	1.54	Other	2	0
427	IPSC.midbrain_primed	0.02	Nonsignificant	0.51	1.18	Other	0	0
428	T.CD4_naive.gut_prone	0.02	Nonsignificant	0.83	1.31	Other	35	70
429	ILC2.quiescent	0.02	Nonsignificant	—	0.59	Other	0	0
430	NEU.INH_VIP.nuclear_reg	0.02	Nonsignificant	—	0.30	Other	20	4
431	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.02	Nonsignificant	—	0.00	Other	0	0
432	IPSC.mesodermal_primed	0.02	Nonsignificant	0.58	1.12	Other	0	0
433	HEP.periportal_metabolic.inflammatory_activated	0.02	Nonsignificant	0.33	1.17	Other	712	1,610
434	HEP.periportal_metabolic.stress_checkpoint	0.02	Nonsignificant	0.33	1.18	Other	234	786
435	T.CD4_Tcm.RNA_control	0.02	Nonsignificant	0.96	1.16	Other	96	4
436	T.CD8_transitional.effector_primed	0.02	Nonsignificant	0.53	1.10	Other	435	151
437	B.germinal_center.LZ_survival	0.02	Nonsignificant	—	0.00	Other	0	0
438	CM.mito_proteostasis	0.02	Nonsignificant	1.00	0.90	Other	329	29
439	T.CD4_Tcm.imprinted_splicing	0.02	Nonsignificant	0.96	1.12	Other	6	17
440	CM.oxidative_phospho	0.02	Nonsignificant	1.00	0.81	Other	266	792
441	EPI.esophageal_suprabasal.differentiating_keratin	0.02	Nonsignificant	9.33e-06	1.47	Other	131	61
442	IPSC.stress	0.02	Nonsignificant	0.04	1.23	Other	0	0
443	T.CD8_naive.lipid_synthesis	0.02	Nonsignificant	0.40	1.35	Other	6	4
444	ASTRO.synaptic_interaction	0.01	Nonsignificant	0.27	1.32	Other	76	334
445	T.CD4_Tcm.baseline	0.01	Nonsignificant	0.96	1.00	Other	61	31
446	EPI.salivary_mucous_acinar.baseline	0.01	Nonsignificant	—	—	Other	394	683
447	HEP.canalicular_transport.injury_stress	0.01	Nonsignificant	1.00	0.45	Other	289	24
448	EPI.renal_immature_ureteric_bud.defense_secretory	0.01	Nonsignificant	0.23	1.19	Other	45	76
449	HEP.canalicular_transport.ductular_like_transition	0.01	Nonsignificant	1.00	0.50	Other	400	87
450	ASTRO.homeostatic	0.01	Nonsignificant	0.97	0.97	Other	200	431
451	FIB.adventitial.complement_angiocrine	0.01	Nonsignificant	1.00	0.88	Other	153	684
452	T.CD4_naive.proteostasis_mitoprot	0.01	Nonsignificant	0.83	1.11	Other	15	37
453	CM.anti_inflammatory	0.01	Nonsignificant	1.00	0.90	Other	424	1,503
454	CM.osmoprotection	0.01	Nonsignificant	1.00	0.86	Other	34	57
455	HEP.periportal_metabolic.acute_phase_barrier	0.01	Nonsignificant	0.33	1.25	Other	533	138
456	MEL.dedifferentiated_migratory	0.01	Nonsignificant	—	0.50	Other	0	0
457	ASTRO.neuromodulatory	0.01	Nonsignificant	0.48	1.27	Other	34	172
458	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.01	Nonsignificant	1.00	0.26	Other	219	533
459	NEU.INH_VIP.enkephalinergic	0.01	Nonsignificant	—	0.45	Other	0	0
460	T.CD4_naive.neddylation_mitoprot	0.01	Nonsignificant	0.83	1.13	Other	93	56
461	EPI.lung_multiciliated.mature_motile_cilia	0.01	Nonsignificant	—	0.89	Other	0	0
462	ILC2.migratory	0.01	Nonsignificant	—	0.00	Other	0	0
463	ASTRO.A2_reactive	0.01	Nonsignificant	1.00	0.77	Other	10	37
464	T.CD4_naive.homeostatic	0.01	Nonsignificant	0.83	1.06	Other	215	108
465	NK.adaptive_classII_inhibitory	0.01	Nonsignificant	0.20	1.07	Other	880	154
466	ASTRO.stress_mito	0.01	Nonsignificant	0.97	1.04	Other	47	110
467	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.01	Nonsignificant	—	0.13	Other	105	368
468	NEU.EXC_IT.structural	9.99e-03	Nonsignificant	1.00	0.88	Other	171	41
469	EPI.renal_proximal_tubule.detox_antioxidant	9.95e-03	Nonsignificant	1.00	0.00	Other	394	77
470	T.CD8_Tcm.helper_like	9.83e-03	Nonsignificant	0.58	1.13	Other	81	159
471	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	9.51e-03	Nonsignificant	—	0.81	Other	0	0
472	HEP.acute_phase.inflammatory	9.30e-03	Nonsignificant	0.99	0.43	Other	382	649
473	T.MAIT.quiescent	9.27e-03	Nonsignificant	0.79	1.22	Other	100	5
474	EPI.ileal_goblet.stress_metallothionein	9.10e-03	Nonsignificant	—	0.00	Other	4	11
475	T.CD8_transitional.early	9.08e-03	Nonsignificant	1.00	0.91	Other	327	55
476	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	9.07e-03	Nonsignificant	—	1.15	Other	0	0
477	MEL.stress_glucocorticoid	8.88e-03	Nonsignificant	0.85	0.88	Other	11	34
478	T.CD4_Tcm.tissue_homing	8.56e-03	Nonsignificant	0.96	0.99	Other	78	46
479	T.CD4_naive.mature	8.50e-03	Nonsignificant	0.83	1.06	Other	211	100
480	T.CD4_Th17.migratory	8.49e-03	Nonsignificant	0.10	1.19	Other	13	23
481	EPI.skin_keratinocyte_basal.transit_amplifying	8.44e-03	Nonsignificant	—	0.00	Other	0	0
482	EPI.ileal_goblet.baseline	8.27e-03	Nonsignificant	0.87	0.65	Other	16	2
483	B.germinal_center.DZ_M_phase	7.73e-03	Nonsignificant	—	0.00	Other	0	0
484	T.CD4_naive.resist_bystander	7.62e-03	Nonsignificant	0.86	1.07	Other	40	25
485	EPI.lung_multiciliated.stress	7.55e-03	Nonsignificant	—	2.22e-04	Other	67	165
486	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	7.42e-03	Nonsignificant	—	0.29	Other	0	0
487	T.CD4_naive.proteostasis	7.27e-03	Nonsignificant	1.00	0.88	Other	14	9
488	T.CD4_Tem.long_term_memory	7.16e-03	Nonsignificant	1.00	0.80	Other	314	587
489	EPI.thymic_medullary.proliferative_APC	7.12e-03	Nonsignificant	—	0.00	Other	0	0
490	CM.sarcomere_actin_interface	7.05e-03	Nonsignificant	1.00	0.73	Other	450	78
491	EPI.pancreatic_islet.beta	6.73e-03	Nonsignificant	0.96	0.36	Other	42	57
492	EPI.lung_multiciliated.baseline	6.67e-03	Nonsignificant	—	0.00	Other	0	7
493	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	6.56e-03	Nonsignificant	0.54	0.99	Other	449	1,034
494	GRNLSA.EMT_insulin_signaling	6.54e-03	Nonsignificant	0.67	1.10	Other	47	84
495	HEP.acute_phase.complement_antiviral	6.46e-03	Nonsignificant	0.99	0.66	Other	377	751
496	PERI.cardiac_skeletal	6.44e-03	Nonsignificant	1.00	0.00	Other	313	630
497	EPI.renal_principal_cell.inflammatory	6.40e-03	Nonsignificant	0.82	1.04	Other	74	157
498	T.CD4_Tcm.migratory_cilium	6.30e-03	Nonsignificant	0.96	0.84	Other	5	10
499	EPI.renal_principal_cell.activated_acute	6.17e-03	Nonsignificant	0.47	1.30	Other	29	59
500	T.CD4_naive.mature_mitoprot	6.05e-03	Nonsignificant	1.00	0.94	Other	212	476
501	IPSC.neural_primed	5.99e-03	Nonsignificant	0.58	1.06	Other	0	0
502	ASTRO.hypoxia_angiogenic	5.86e-03	Nonsignificant	0.97	0.90	Other	5	18
503	MEL.secretory_quiescent	5.79e-03	Nonsignificant	0.85	0.78	Other	19	13
504	T.CD4_naive.neddylation	5.63e-03	Nonsignificant	1.00	0.82	Other	104	222
505	ILC2.activated	5.61e-03	Nonsignificant	—	0.00	Other	0	0
506	T.MAIT.MAPK_brake	5.58e-03	Nonsignificant	0.81	0.79	Other	44	66
507	EPI.hepatic_ductular_cholangiocyte.polarity	5.50e-03	Nonsignificant	—	0.00	Other	0	0
508	HEP.periportal_metabolic.xenobiotic_detox	5.43e-03	Nonsignificant	1.00	0.86	Other	1,440	139
509	T.MAIT.vesicle	5.36e-03	Nonsignificant	0.81	0.65	Other	37	65
510	EPI.hepatic_ductular_cholangiocyte.secretory_transport	5.30e-03	Nonsignificant	—	0.00	Other	0	0
511	EPI.renal_principal_cell.injury_repair	5.30e-03	Nonsignificant	0.82	0.69	Other	26	9
512	T.CD4_Tcm.DC_interact	5.23e-03	Nonsignificant	0.96	0.80	Other	72	32
513	T.MAIT.cytotoxic	5.13e-03	Nonsignificant	0.81	0.95	Other	52	15
514	T.MAIT.migratory	5.05e-03	Nonsignificant	0.81	0.76	Other	10	1
515	T.CD4_Th17.cytotoxic	4.90e-03	Nonsignificant	0.20	1.12	Other	332	123
516	EPI.renal_principal_cell.intercalated_like	4.83e-03	Nonsignificant	0.82	0.76	Other	63	66
517	T.CD8_naive.nfkb_related	4.60e-03	Nonsignificant	0.62	1.15	Other	1	0
518	FIB.adventitial.baseline	4.55e-03	Nonsignificant	1.00	0.68	Other	157	278
519	HEP.acute_phase.proliferative	4.47e-03	Nonsignificant	—	0.00	Other	4	6
520	T.CD4_Tcm.regulatory_poised	4.44e-03	Nonsignificant	0.96	0.74	Other	2	3
521	T.CD4_Tcm.effector_like	4.28e-03	Nonsignificant	0.96	0.79	Other	293	533
522	CHOND.pro_inflammatory	4.23e-03	Nonsignificant	1.00	0.16	Other	181	351
523	EPI.hepatic_ductular_cholangiocyte.ion_transport	4.21e-03	Nonsignificant	—	0.00	Other	0	0
524	HEP.periportal_metabolic.canonical_urea_cycle	4.21e-03	Nonsignificant	1.00	0.62	Other	1,464	269
525	EPI.pancreatic_islet.delta	4.18e-03	Nonsignificant	—	0.00	Other	0	0
526	GRNLSA.secretory_remodeling	4.14e-03	Nonsignificant	0.67	1.14	Other	90	25
527	T.CD4_Tcm.stress	3.94e-03	Nonsignificant	0.96	0.75	Other	5	11
528	NK.adaptive_HLAE_tuned	3.68e-03	Nonsignificant	0.20	1.06	Other	1,124	189
529	T.CD4_naive.survival	3.58e-03	Nonsignificant	1.00	0.71	Other	12	17
530	T.CD4_naive.purinergic	3.55e-03	Nonsignificant	1.00	0.71	Other	49	1
531	NEU.INH_LAMP5.projecting	3.54e-03	Nonsignificant	—	0.53	Other	0	0
532	HEP.periportal_metabolic.urea_onecarbon_secretory	3.21e-03	Nonsignificant	1.00	0.67	Other	1,332	3,053
533	NEU.INH_LAMP5.exc_inh_balance	3.20e-03	Nonsignificant	—	0.16	Other	46	2
534	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	3.15e-03	Nonsignificant	—	0.00	Other	0	0
535	SCHWN.axon_contact_cardiac	3.14e-03	Nonsignificant	0.99	0.23	Other	18	63
536	MEL.mature_oxidative_traffic	3.06e-03	Nonsignificant	0.85	1.02	Other	247	285
537	IPSC.neuroendocrine_primed	3.05e-03	Nonsignificant	—	1.32	Other	0	0
538	EPI.pancreatic_ductal_progenitor.baseline	3.04e-03	Nonsignificant	0.62	0.98	Other	179	702
539	PLAT.megakaryocytic	3.02e-03	Nonsignificant	—	0.00	Other	0	0
540	T.CD4_naive.survival_neddylation	2.98e-03	Nonsignificant	1.00	0.71	Other	26	38
541	T.CD4_naive.survival_mitoprot	2.96e-03	Nonsignificant	1.00	0.66	Other	13	7
542	EPI.skin_appendage_keratinocyte.transit_amplifying	2.93e-03	Nonsignificant	—	0.00	Other	109	358
543	T.CD8_transitional.APC_like	2.92e-03	Nonsignificant	1.00	0.75	Other	205	62
544	NEU.EXC_SYT2.synaptic	2.85e-03	Nonsignificant	—	0.48	Other	0	0
545	T.CD4_Tcm.secretory	2.82e-03	Nonsignificant	0.96	0.66	Other	20	11
546	ADIPO.inflammatory	2.80e-03	Nonsignificant	—	0.00	Other	0	0
547	OLG.stress	2.72e-03	Nonsignificant	0.20	1.36	Other	232	8
548	T.CD8_naive.baseline	2.69e-03	Nonsignificant	0.90	0.77	Other	142	2
549	NEU.INH_VIP.excitatory_coupled	2.64e-03	Nonsignificant	—	0.00	Other	13	0
550	NK.immature_bridge	2.64e-03	Nonsignificant	1.00	1.02	Other	117	122
551	T.CD8_Tcm.baseline	2.62e-03	Nonsignificant	0.93	1.03	Other	90	89
552	T.CD8_naive.cytokine_dampened	2.47e-03	Nonsignificant	0.90	0.76	Other	71	4
553	T.CD4_Tcm.synapse_dynamics	2.45e-03	Nonsignificant	0.96	0.64	Other	15	10
554	T.CD8_naive.splicing_enriched	2.38e-03	Nonsignificant	0.80	0.98	Other	120	16
555	EPI.pancreatic_acinar.metabolic_onecarbon	2.33e-03	Nonsignificant	1.00	0.00	Other	287	328
556	SKM.type_2_fast.oxidative_IIa	2.27e-03	Nonsignificant	0.06	1.10	Other	946	56
557	GRNLSA.lipid_hypoxia	2.24e-03	Nonsignificant	0.99	0.83	Other	28	0
558	GRNLSA.stress_metabolic	2.11e-03	Nonsignificant	—	0.00	Other	1	2
559	EPI.thymic_cortical.secretory_remodeling	2.10e-03	Nonsignificant	—	0.69	Other	4	1
560	T.CD4_Tcm.crosstalk_myeloid	2.08e-03	Nonsignificant	0.96	0.74	Other	5	4
561	T.CD4_Tcm.retro_ZNF117	2.04e-03	Nonsignificant	0.96	0.68	Other	5	9
562	T.CD4_Tcm.Th2_like	1.98e-03	Nonsignificant	0.96	0.87	Other	23	55
563	T.CD4_Tem.cytotoxic_effector	1.97e-03	Nonsignificant	1.00	0.48	Other	225	398
564	T.CD8_Tcm.NK_like	1.96e-03	Nonsignificant	0.93	1.00	Other	334	581
565	T.CD8_naive.innate_like	1.84e-03	Nonsignificant	0.86	0.92	Other	10	1
566	EPI.salivary_myoepithelial.contractile_repair	1.82e-03	Nonsignificant	—	0.54	Other	3	9
567	T.CD4_Th17.baseline	1.81e-03	Nonsignificant	0.85	0.91	Other	51	5
568	ASTRO.stress_acute	1.79e-03	Nonsignificant	1.00	0.21	Other	60	56
569	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.77e-03	Nonsignificant	—	0.00	Other	0	0
570	NEU.INH_LAMP5.glial_interface	1.77e-03	Nonsignificant	—	0.00	Other	0	0
571	NEU.INH_PVALB.chandelier	1.68e-03	Nonsignificant	0.31	1.31	Other	19	16
572	EPI.extrahepatic_cholangiocyte.barrier_interface	1.65e-03	Nonsignificant	—	0.00	Other	0	0
573	T.CD4_cytotoxic.precursor	1.61e-03	Nonsignificant	0.36	1.20	Other	156	67
574	HEP.periportal_metabolic.stress_chaperone	1.60e-03	Nonsignificant	—	0.00	Other	66	128
575	NEU.INH_LAMP5.rosehip	1.55e-03	Nonsignificant	—	0.00	Other	0	0
576	NEU.INH_VIP.regulatory_remodeling	1.47e-03	Nonsignificant	—	0.00	Other	6	1
577	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	1.45e-03	Nonsignificant	—	0.97	Other	0	0
578	EPI.skin_follicular_keratinizing.transit_amplifying	1.44e-03	Nonsignificant	—	0.38	Other	21	49
579	NEU.INH_VIP.opioid	1.38e-03	Nonsignificant	—	0.00	Other	50	9
580	OLG.myelinating_mature	1.23e-03	Nonsignificant	0.85	1.03	Other	363	94
581	T.gamma_delta.early_effector	1.22e-03	Nonsignificant	0.41	1.05	Other	89	0
582	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.17e-03	Nonsignificant	—	0.00	Other	49	237
583	HEP.canalicular_transport.sterol_lipid_biosynthesis	1.17e-03	Nonsignificant	—	0.00	Other	10	20
584	IPSC.mesendo_primed	1.13e-03	Nonsignificant	0.75	1.02	Other	0	0
585	FIB.adventitial.mechano_chemo_sensing	1.11e-03	Nonsignificant	1.00	0.48	Other	135	524
586	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.10e-03	Nonsignificant	—	0.27	Other	0	0
587	EPI.salivary_myoepithelial.activated	1.06e-03	Nonsignificant	0.61	0.95	Other	85	281
588	NEU.INH_PVALB.metabotropic	1.06e-03	Nonsignificant	—	0.58	Other	0	0
589	NEU.INH_PVALB.nuclear_reg	1.04e-03	Nonsignificant	0.59	1.02	Other	25	12
590	EPI.esophageal_basal.junctional_barrier	1.03e-03	Nonsignificant	—	0.00	Other	0	0
591	ASTRO.A1_reactive	1.02e-03	Nonsignificant	1.00	0.06	Other	433	394
592	EPI.skin_follicular_keratinizing.root_infundibulum	9.72e-04	Nonsignificant	—	0.14	Other	0	0
593	OLG.regulatory_activated	8.90e-04	Nonsignificant	0.83	1.14	Other	196	614
594	CM.inflammatory	8.82e-04	Nonsignificant	—	0.00	Other	0	0
595	HPC.MEP	8.68e-04	Nonsignificant	1.00	0.16	Other	599	1,195
596	EPI.hepatic_ductular_cholangiocyte.stress	8.64e-04	Nonsignificant	—	0.00	Other	0	0
597	IPSC.mesenchymal_primed	8.48e-04	Nonsignificant	1.00	0.85	Other	0	0
598	IPSC.canonical_pluripotent	8.48e-04	Nonsignificant	1.00	0.85	Other	0	0
599	EPI.salivary_myoepithelial.baseline	8.41e-04	Nonsignificant	0.61	0.95	Other	42	141
600	OLG.regulatory	8.01e-04	Nonsignificant	0.85	1.04	Other	353	73
601	EPI.skin_follicular_keratinizing.upper_infundibulum	7.80e-04	Nonsignificant	—	0.00	Other	8	2
602	NEU.EXC_IT.transitional	7.49e-04	Nonsignificant	1.00	0.92	Other	237	142
603	T.CD8_Tem.baseline	7.26e-04	Nonsignificant	0.79	1.00	Other	458	356
604	T.CD8_Tem.signaling_turnover	6.83e-04	Nonsignificant	0.47	1.08	Other	425	683
605	T.CD4_cytotoxic.activated	6.78e-04	Nonsignificant	0.88	1.09	Other	3	1
606	EPI.esophageal_suprabasal.basal_transitional	6.64e-04	Nonsignificant	0.99	0.26	Other	44	67
607	NEU.EXC_CT.remodeling	6.33e-04	Nonsignificant	—	0.80	Other	23	1
608	EPI.pancreatic_ductal_progenitor.ADM_like	6.07e-04	Nonsignificant	—	0.18	Other	0	0
609	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	5.93e-04	Nonsignificant	—	0.17	Other	0	0
610	OLG.myelinating_stress	5.80e-04	Nonsignificant	0.89	0.85	Other	232	62
611	NK.cytokine_axis_baseline	5.76e-04	Nonsignificant	1.00	0.97	Other	1,172	116
612	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	5.54e-04	Nonsignificant	—	0.00	Other	0	0
613	T.CD4_naive.activated_stress	5.33e-04	Nonsignificant	1.00	0.10	Other	339	429
614	T.CD8_naive.mito_proteostasis	5.32e-04	Nonsignificant	1.00	0.33	Other	428	100
615	EPI.skin_interfollicular_spinous.inflammatory	5.02e-04	Nonsignificant	—	1.59	Other	0	0
616	EPI.salivary_myoepithelial.junctional_transport	4.86e-04	Nonsignificant	0.61	1.04	Other	66	121
617	NK.cytokine_tissue_resident	4.79e-04	Nonsignificant	1.00	1.02	Other	74	82
618	NK.adaptive_axis_baseline	4.61e-04	Nonsignificant	0.20	1.06	Other	1,008	153
619	NEU.INH_VIP.canonical_disinhibitory	4.50e-04	Nonsignificant	0.98	0.35	Other	59	38
620	NEU.INH_VIP.serotonergic	4.47e-04	Nonsignificant	—	0.00	Other	9	2
621	OLG.vesicle_trafficking	4.28e-04	Nonsignificant	0.89	0.83	Other	124	10
622	EPI.esophageal_suprabasal.proliferative_S	4.26e-04	Nonsignificant	—	0.00	Other	26	41
623	T.CD8_Tem.TEMRA	4.21e-04	Nonsignificant	0.79	0.99	Other	920	1,088
624	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	4.19e-04	Nonsignificant	—	0.00	Other	0	0
625	SKM.type_2_fast.glycolytic_IIx_IIb	3.91e-04	Nonsignificant	0.59	0.99	Other	565	1,482
626	T.gamma_delta.cytotoxic_effector	3.75e-04	Nonsignificant	0.72	0.97	Other	349	109
627	OLG.reactive_repair	3.71e-04	Nonsignificant	0.94	0.64	Other	385	385
628	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	3.65e-04	Nonsignificant	0.78	1.03	Other	7	16
629	T.gamma_delta.central_memory	3.29e-04	Nonsignificant	0.20	1.09	Other	460	919
630	NEU.EXC_CT.projector	2.97e-04	Nonsignificant	0.73	0.90	Other	87	26
631	EPI.skin_hair_follicle_bulge.anagen_growth	2.56e-04	Nonsignificant	—	0.00	Other	0	0
632	FIB.adventitial.mito_secretory	2.51e-04	Nonsignificant	1.00	0.34	Other	21	7
633	EPI.esophageal_suprabasal.proliferative_exit	2.41e-04	Nonsignificant	—	0.00	Other	0	0
634	EPI.skin_interfollicular_spinous.upper_lipid	2.06e-04	Nonsignificant	—	0.98	Other	6	6
635	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	2.04e-04	Nonsignificant	0.78	0.69	Other	33	34
636	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.94e-04	Nonsignificant	—	0.00	Other	0	0
637	NK.adaptive_adipose_stress	1.91e-04	Nonsignificant	1.00	0.97	Other	374	39
638	IPSC.stromal_primed	1.88e-04	Nonsignificant	1.00	0.68	Other	0	0
639	NK.adaptive_immature_precursor	1.79e-04	Nonsignificant	1.00	0.95	Other	358	111
640	GRNLSA.p53_damage	1.64e-04	Nonsignificant	—	0.00	Other	13	10
641	GRNLSA.angiocrine_mechanosensory	1.63e-04	Nonsignificant	—	0.10	Other	0	0
642	GRNLSA.proliferative_migratory	1.61e-04	Nonsignificant	0.99	0.38	Other	248	292
643	T.CD8_Tcm.effector_bias	1.35e-04	Nonsignificant	1.00	0.47	Other	199	329
644	T.CD4_cytotoxic.NK_adapted	1.25e-04	Nonsignificant	0.89	1.00	Other	82	33
645	EPI.skin_hair_follicle_companion.activated_migratory	1.13e-04	Nonsignificant	—	0.00	Other	0	0
646	NEU.EXC_CT.Ca2_signaling	1.08e-04	Nonsignificant	—	0.00	Other	68	17
647	EPI.skin_keratinocyte_basal.basement_anchoring	9.78e-05	Nonsignificant	—	0.00	Other	0	0
648	EPI.skin_interfollicular_spinous.stress_oxidative	9.37e-05	Nonsignificant	—	0.43	Other	0	0
649	NEU.INH_PVALB.fastspike	9.27e-05	Nonsignificant	—	0.00	Other	24	22
650	NEU.EXC_NTNG1.synaptic	8.65e-05	Nonsignificant	—	0.67	Other	0	0
651	IPSC.axial_identity_primed	7.43e-05	Nonsignificant	1.00	0.43	Other	0	0
652	NEU.INH_PVALB.neuromodulatory	7.35e-05	Nonsignificant	—	0.00	Other	0	0
653	EPI.skin_interfollicular_spinous.early_differentiation	6.96e-05	Nonsignificant	0.76	1.12	Other	89	19
654	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	5.98e-05	Nonsignificant	—	0.00	Other	0	0
655	EPI.esophageal_suprabasal.proliferative_G2M	5.55e-05	Nonsignificant	—	0.00	Other	0	0
656	T.CD4_cytotoxic.baseline	5.09e-05	Nonsignificant	0.89	0.94	Other	0	0
657	T.CD4_cytotoxic.terminal_effector	4.25e-05	Nonsignificant	0.98	0.77	Other	286	21
658	NEU.INH_PVALB.serotonergic	3.07e-05	Nonsignificant	—	0.00	Other	0	0
659	EPI.renal_distal_tubule.immune_modulatory	2.96e-05	Nonsignificant	—	0.00	Other	0	0
660	NEU.EXC_IT.neuromodulated	2.79e-05	Nonsignificant	1.00	0.40	Other	176	116
661	EPI.skin_keratinocyte_proliferating.anchor_remodel	2.69e-05	Nonsignificant	—	0.00	Other	0	0
662	IPSC.proliferative	2.56e-05	Nonsignificant	1.00	0.24	Other	0	0
663	NK.cytokine_biosynthetic_primed	2.08e-05	Nonsignificant	1.00	0.95	Other	360	21
664	T.CD8_Tcm.gut_homing	2.06e-05	Nonsignificant	1.00	0.17	Other	380	112
665	EPI.thymic_cortical.baseline	1.93e-05	Nonsignificant	0.90	0.39	Other	185	386
666	EPI.thymic_cortical.Notch_interface	1.90e-05	Nonsignificant	—	0.00	Other	82	137
667	EPI.skin_interfollicular_spinous.stress_UPR	1.65e-05	Nonsignificant	—	0.27	Other	0	0
668	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.44e-05	Nonsignificant	—	0.00	Other	39	82
669	SKM.type_1_slow.contractile	1.31e-05	Nonsignificant	0.55	1.14	Other	596	8
670	EPI.skin_sweat_duct_keratinocyte.proliferative_S	1.23e-05	Nonsignificant	—	0.00	Other	0	0
671	EPI.skin_interfollicular_spinous.baseline	9.74e-06	Nonsignificant	1.00	0.60	Other	35	3
672	NK.cytokine_quiescent	9.40e-06	Nonsignificant	1.00	0.88	Other	623	1,062
673	NK.adaptive_terminal_cytotoxic	8.83e-06	Nonsignificant	1.00	0.85	Other	485	802
674	SKM.type_1_slow.glycolytic	7.47e-06	Nonsignificant	0.55	1.10	Other	362	647
675	EPI.skin_sweat_duct_keratinocyte.signal_gate	5.97e-06	Nonsignificant	—	0.00	Other	43	26
676	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	5.83e-06	Nonsignificant	—	0.00	Other	0	0
677	NK.cytokine_vascular_patrolling	5.62e-06	Nonsignificant	1.00	0.84	Other	863	94
678	SKM.type_1_slow.oxidative	5.30e-06	Nonsignificant	0.89	0.77	Other	802	251
679	NEU.EXC_IT.adhesion	4.88e-06	Nonsignificant	1.00	0.20	Other	252	108
680	T.CD8_Tem.motility_primed	4.80e-06	Nonsignificant	0.79	0.90	Other	269	4
681	NK.adaptive_biosynthetic_primed	4.69e-06	Nonsignificant	1.00	0.88	Other	244	405
682	EPI.skin_interfollicular_spinous.proliferative	3.81e-06	Nonsignificant	—	0.00	Other	0	0
683	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.99e-06	Nonsignificant	—	0.00	Other	135	290
684	NK.cytokine_tissue_activation	1.92e-06	Nonsignificant	1.00	0.81	Other	267	450
685	EPI.skin_interfollicular_spinous.transition_basal	1.04e-06	Nonsignificant	1.00	0.19	Other	100	127
686	NEU.EXC_SYT2.nuclear_reg	4.49e-07	Nonsignificant	—	0.00	Other	0	0
687	NEU.EXC_CT.Ca2_sensor	4.23e-07	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_NTNG1.nuclear_reg	1.85e-07	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

3 unique genes. Showing 1–3. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ENSG00000302418	02-Medium	0.64	6.55	G1	C2	—	—	—	8	29
JADE2	02-Medium	0.62	5.89	G1	C2	—	—	20 cells — complete matches	6	18
ENSG00000300625	02-Medium	0.42	5.89	G2	C2	—	—	—	9	13

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.