Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000336 · All tissues

Congenital malformations of heart and great arteries: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Congenital cardiovascular malformations

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	cardiomyocyte	11.73	Significant	1.94e-28	1.23	Specific	533	2,045
2	endothelial_cell	10.85	Significant	3.30e-49	1.24	Specific	373	974
3	epithelial_cell	4.21	Nominal	2.05e-14	1.10	Other	24	47
4	oligodendrocyte	3.51	Nominal	4.63e-07	1.11	Other	385	1,507
5	skeletal_muscle_cell	3.33	Nominal	0.64	1.04	Other	944	2,600
6	pericyte	3.27	Nominal	0.13	1.06	Other	128	517
7	smooth_muscle_cell	1.77	Nonsignificant	1.00	0.97	Other	27	139
8	platelet	1.70	Nonsignificant	—	0.23	Other	85	104
9	chondrocyte	1.09	Nonsignificant	1.00	0.82	Other	548	1,069
10	adipocyte	0.93	Nonsignificant	1.00	0.87	Other	33	111
11	natural_killer_cell	0.50	Nonsignificant	1.00	0.77	Other	1,204	2,052
12	adipose_stem_and_progenitor_cell	0.29	Nonsignificant	1.00	0.63	Other	327	954
13	T_cell	0.27	Nonsignificant	1.00	0.61	Other	470	959
14	B_cell	0.26	Nonsignificant	1.00	0.77	Other	356	694
15	haematopoietic_progenitor_cell	0.22	Nonsignificant	1.00	0.62	Other	262	502
16	plasma_cell	0.15	Nonsignificant	1.00	0.53	Other	17	24
17	innate_lymphoid_cell_2	0.11	Nonsignificant	1.00	0.57	Other	3	8
18	fibroblast	0.08	Nonsignificant	1.00	0.44	Other	184	826
19	hepatocyte	0.06	Nonsignificant	1.00	0.48	Other	1,515	3,822
20	granulosa_cell	0.06	Nonsignificant	1.00	0.48	Other	293	670
21	muscle_stem_cell	0.06	Nonsignificant	1.00	0.43	Other	7	27
22	astrocyte	0.06	Nonsignificant	1.00	0.75	Other	256	1,203
23	neuron	0.05	Nonsignificant	1.00	0.64	Other	330	1,328
24	granulocyte	0.05	Nonsignificant	1.00	0.51	Other	5	6
25	monocyte	0.03	Nonsignificant	1.00	0.66	Other	2,176	3,871
26	induced_pluripotent_stem_cell	0.03	Nonsignificant	1.00	0.53	Other	0	0
27	macrophage	0.03	Nonsignificant	1.00	0.35	Other	813	1,732
28	thymocyte	0.02	Nonsignificant	1.00	0.41	Other	168	512
29	mesothelial_cell	0.02	Nonsignificant	1.00	0.34	Other	6	36
30	schwann_cell	0.01	Nonsignificant	1.00	0.32	Other	10	57
31	dendritic_cell	0.01	Nonsignificant	1.00	0.35	Other	496	724
32	microglia	6.53e-03	Nonsignificant	1.00	0.28	Other	61	129
33	melanocyte	4.64e-03	Nonsignificant	1.00	0.30	Other	97	309
34	oligodendrocyte_precursor_cell	7.29e-04	Nonsignificant	1.00	0.18	Other	461	1,454

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_appendage_keratinocyte	14.89	Significant	1.37e-03	1.54	Specific	87	222
2	EC.venous	14.28	Significant	1.05e-04	1.38	Specific	516	1,387
3	EC.capillary	13.83	Significant	4.04e-05	1.44	Specific	514	1,635
4	EPI.tracheal_basal	11.83	Significant	3.81e-03	1.51	Specific	398	1,120
5	EPI.tracheal_suprabasal	11.77	Significant	0.26	1.43	Relevant	29	56
6	CM.cardiomyocyte	11.73	Significant	—	—	Specific	524	2,032
7	EPI.salivary_duct_excretory	11.63	Significant	4.81e-03	1.51	Specific	85	180
8	EPI.salivary_intercalated_defense	11.18	Significant	1.70e-03	1.52	Specific	81	161
9	EC.arterial	11.07	Significant	1.00	0.82	Specific	356	885
10	EPI.colonocyte	9.48	Significant	1.08e-05	1.48	Specific	294	815
11	EPI.lung_club_secretory	8.32	Significant	0.26	1.35	Relevant	5	14
12	EPI.salivary_myoepithelial	8.27	Significant	1.37e-03	1.46	Specific	191	714
13	EPI.salivary_serous_acinar	8.23	Significant	1.52e-07	1.47	Specific	233	531
14	SKM.type_1_slow	7.14	Significant	8.87e-34	1.85	Specific	923	2,478
15	EPI.renal_principal_cell	6.45	Significant	1.00	1.06	Relevant	207	403
16	EPI.skin_keratinocyte_basal	6.25	Significant	—	0.30	Other	13	26
17	EPI.renal_immature_ureteric_bud	5.26	Nominal	1.00	1.00	Other	217	569
18	EPI.thymic_cortical	5.04	Nominal	0.41	1.25	Other	442	824
19	EPI.salivary_mucous_acinar	4.70	Nominal	0.38	1.17	Other	639	1,189
20	EPI.renal_intercalated_cell_type_A	4.61	Nominal	1.00	0.92	Other	67	142
21	EPI.skin_sweat_duct_keratinocyte	4.58	Nominal	1.00	1.05	Other	146	301
22	EPI.cervical_suprabasal	4.19	Nominal	—	0.31	Other	14	50
23	EPI.skin_hair_follicle_bulge	4.16	Nominal	1.00	0.90	Other	51	178
24	EPI.renal_distal_tubule	4.03	Nominal	1.00	0.92	Other	133	361
25	EPI.salivary_duct_ion_transport	3.99	Nominal	1.00	0.91	Other	5	11
26	EPI.skin_keratinocyte_proliferating	3.64	Nominal	1.00	0.70	Other	47	76
27	OLG.oligodendrocyte	3.51	Nominal	—	—	Other	384	1,397
28	PERI.pericyte	3.27	Nominal	—	—	Other	117	0
29	EPI.endocervical_secretory	3.08	Nominal	—	0.18	Other	0	0
30	EPI.pancreatic_ductal_progenitor	2.95	Nonsignificant	1.00	0.85	Other	234	873
31	EPI.pancreatic_acinar	2.93	Nonsignificant	1.00	0.79	Other	429	1,475
32	EPI.skin_sebaceous_duct_luminal	2.84	Nonsignificant	1.00	0.68	Other	100	249
33	EPI.pancreatic_ductal_mucinous	2.54	Nonsignificant	1.00	0.72	Other	219	430
34	EPI.esophageal_basal	2.10	Nonsignificant	1.00	0.72	Other	4	10
35	EPI.gastric_foveolar	2.09	Nonsignificant	—	0.00	Other	0	0
36	EPI.skin_keratinocyte_progenitor	2.06	Nonsignificant	—	0.00	Other	0	3
37	EPI.esophageal_suprabasal	1.85	Nonsignificant	1.00	0.71	Other	158	404
38	EC.heart_remodeling	1.84	Nonsignificant	1.00	0.13	Other	569	1,594
39	EPI.skin_follicular_keratinizing	1.83	Nonsignificant	1.00	0.53	Other	30	81
40	SMC.smooth_muscle_cell	1.77	Nonsignificant	—	—	Other	20	101
41	EPI.renal_intercalated_cell_type_B	1.76	Nonsignificant	—	0.00	Other	6	7
42	EPI.renal_thick_ascending_limb	1.75	Nonsignificant	1.00	0.41	Other	453	1,153
43	PLAT.platelet	1.70	Nonsignificant	—	0.00	Other	38	53
44	EPI.lung_multiciliated	1.65	Nonsignificant	1.00	0.62	Other	16	49
45	EPI.ectocervical_granular	1.49	Nonsignificant	—	0.00	Other	11	23
46	EPI.ileal_enterocyte_crypt	1.20	Nonsignificant	1.00	0.33	Other	67	113
47	CHOND.chondrocyte	1.09	Nonsignificant	—	—	Other	519	730
48	EC.lymphatic	0.98	Nonsignificant	1.00	0.14	Other	630	998
49	ADIPO.adipocyte	0.93	Nonsignificant	—	—	Other	20	62
50	EPI.colonic_tuft	0.89	Nonsignificant	—	0.00	Other	7	24
51	EPI.tracheal_submucosal_gland	0.81	Nonsignificant	—	0.00	Other	0	0
52	EPI.ileal_bile_transport	0.78	Nonsignificant	1.00	0.40	Other	61	93
53	EPI.ileal_enterocyte_absorptive	0.74	Nonsignificant	1.00	0.35	Other	118	338
54	EPI.alveolar_type_1	0.74	Nonsignificant	1.00	0.40	Other	26	101
55	EPI.skin_interfollicular_spinous	0.72	Nonsignificant	1.00	0.22	Other	260	563
56	EPI.alveolar_type_2	0.70	Nonsignificant	1.00	0.31	Other	813	1,853
57	EPI.renal_proximal_tubule	0.68	Nonsignificant	1.00	0.40	Other	525	806
58	T.CD4_Tfh	0.66	Nonsignificant	0.01	1.54	Other	47	45
59	T.CD4_Th2	0.64	Nonsignificant	—	0.86	Other	1	2
60	EPI.thymic_medullary	0.63	Nonsignificant	1.00	0.25	Other	26	133
61	FIB.lung_alveolar	0.61	Nonsignificant	—	2.15	Other	6	15
62	FIB.tracheal_subepithelial	0.58	Nonsignificant	—	1.83	Other	0	0
63	EPI.pancreatic_ductal_perivascular	0.54	Nonsignificant	1.00	0.18	Other	4	30
64	T.CD4_Treg	0.53	Nonsignificant	0.01	1.47	Other	244	511
65	SKM.type_2_fast	0.51	Nonsignificant	1.00	0.00	Other	972	2,639
66	NK.natural_killer_cell	0.50	Nonsignificant	—	—	Other	1,204	2,045
67	NEU.INH_PVALB	0.46	Nonsignificant	0.02	1.12	Other	193	183
68	T.CD4_naive	0.46	Nonsignificant	3.57e-23	1.45	Other	399	866
69	T.CD4_Th17	0.45	Nonsignificant	0.49	1.14	Other	421	794
70	EPI.skin_hair_follicle_companion	0.41	Nonsignificant	—	0.00	Other	8	12
71	EPI.ileal_goblet	0.40	Nonsignificant	1.00	0.24	Other	181	432
72	T.CD4_Tcm	0.40	Nonsignificant	0.01	1.22	Other	494	988
73	B.naive	0.34	Nonsignificant	0.13	1.07	Other	307	595
74	FIB.barrier_purinergic	0.32	Nonsignificant	—	1.57	Other	1	3
75	ASPC.adipose_stem_and_progenitor_cell	0.29	Nonsignificant	—	—	Other	324	930
76	FIB.hepatic_stellate_cell	0.29	Nonsignificant	—	1.45	Other	64	252
77	HPC.haematopoietic_progenitor_cell	0.22	Nonsignificant	—	—	Other	211	370
78	T.CD4_Tem	0.22	Nonsignificant	1.00	0.82	Other	365	697
79	T.gamma_delta	0.21	Nonsignificant	1.00	0.85	Other	588	1,078
80	B.memory	0.18	Nonsignificant	1.00	0.96	Other	442	882
81	T.CD4_transitional	0.17	Nonsignificant	1.00	0.79	Other	48	110
82	EPI.intrahepatic_cholangiocyte_transport	0.17	Nonsignificant	—	0.00	Other	12	42
83	FIB.reticular	0.16	Nonsignificant	0.95	1.16	Other	19	87
84	T.MAIT	0.15	Nonsignificant	1.00	0.61	Other	469	855
85	PC.IgA_muocsal	0.15	Nonsignificant	0.57	1.10	Other	18	31
86	MAC.alveolar	0.14	Nonsignificant	3.26e-04	1.26	Other	1,432	3,122
87	T.CD8_Tem	0.14	Nonsignificant	1.00	0.50	Other	1,083	1,857
88	T.CD4_Trm	0.13	Nonsignificant	1.00	0.97	Other	176	363
89	T.CD8_Trm	0.13	Nonsignificant	1.00	0.61	Other	211	346
90	EPI.hepatic_ductular_cholangiocyte	0.12	Nonsignificant	1.00	0.61	Other	83	243
91	T.CD4_cytotoxic	0.11	Nonsignificant	1.00	0.45	Other	855	1,493
92	PC.IgG_systemic	0.11	Nonsignificant	0.57	0.96	Other	41	60
93	ILC2.innate_lymphoid_cell_2	0.11	Nonsignificant	—	—	Other	2	0
94	HEP.canalicular_transport	0.10	Nonsignificant	7.63e-09	1.21	Other	1,290	3,434
95	T.CD8_Tcm	0.09	Nonsignificant	1.00	0.34	Other	460	926
96	T.CD8_transitional	0.09	Nonsignificant	1.00	0.40	Other	497	932
97	MAC.microglia_like	0.09	Nonsignificant	0.54	1.17	Other	124	179
98	FIB.interstitial	0.09	Nonsignificant	0.84	1.10	Other	288	940
99	EPI.colonic_enteroendocrine	0.08	Nonsignificant	—	0.00	Other	1	1
100	FIB.adventitial	0.08	Nonsignificant	1.00	0.99	Other	268	1,447
101	GRANU.MAST	0.08	Nonsignificant	1.90e-03	1.69	Other	5	6
102	DC.mig	0.08	Nonsignificant	—	1.92	Other	89	156
103	T.CD8_naive	0.08	Nonsignificant	1.00	0.21	Other	317	708
104	HEP.periportal_metabolic	0.07	Nonsignificant	0.09	1.06	Other	1,750	4,427
105	EPI.extrahepatic_cholangiocyte	0.07	Nonsignificant	—	0.00	Other	37	71
106	EPI.bile_duct_cholangiocyte	0.06	Nonsignificant	1.00	0.10	Other	37	60
107	GRNLSA.granulosa_cell	0.06	Nonsignificant	—	—	Other	257	0
108	MUSC.muscle_stem_cell	0.06	Nonsignificant	—	—	Other	4	18
109	EPI.pancreatic_islet	0.06	Nonsignificant	1.00	0.15	Other	52	132
110	ASTRO.astrocyte	0.06	Nonsignificant	—	—	Other	228	1,111
111	EPI.intrahepatic_cholangiocyte_defense	0.06	Nonsignificant	—	0.00	Other	8	13
112	FIB.perivascular_interface	0.05	Nonsignificant	1.00	0.77	Other	0	0
113	FIB.transitioning	0.04	Nonsignificant	1.00	0.80	Other	172	497
114	MAC.kupffer	0.04	Nonsignificant	0.54	1.12	Other	189	530
115	DC.cDC1	0.04	Nonsignificant	0.50	1.14	Other	55	112
116	MONO.CD14	0.04	Nonsignificant	1.41e-08	1.10	Other	2,294	4,139
117	IPSC.induced_pluripotent_stem_cell	0.03	Nonsignificant	—	—	Other	0	0
118	HEP.pericentral_lipoprotein	0.03	Nonsignificant	—	0.51	Other	0	0
119	MAC.resident_iron	0.02	Nonsignificant	1.00	0.93	Other	16	21
120	B.germinal_center	0.02	Nonsignificant	1.00	0.91	Other	233	655
121	THYMO.thymocyte	0.02	Nonsignificant	—	—	Other	163	495
122	FIB.suburothelial	0.02	Nonsignificant	1.00	0.57	Other	122	432
123	MAC.LAM	0.02	Nonsignificant	1.00	0.87	Other	914	2,064
124	MESO.mesothelial_cell	0.02	Nonsignificant	—	—	Other	2	18
125	EPI.pancreatic_ductal_bicarbonate	0.02	Nonsignificant	1.00	0.03	Other	131	548
126	MAC.MDM	0.01	Nonsignificant	1.00	0.87	Other	623	986
127	FIB.neurolectin_mucosa	0.01	Nonsignificant	1.00	0.32	Other	133	394
128	EC.liver_sinusoidal	0.01	Nonsignificant	1.00	0.00	Other	1,083	1,925
129	SCHWN.schwann_cell	0.01	Nonsignificant	—	—	Other	7	33
130	MAC.proliferating	0.01	Nonsignificant	1.00	0.90	Other	87	253
131	DC.cDC2	8.85e-03	Nonsignificant	1.00	0.86	Other	1,189	1,793
132	FIB.skin_neurosecretory	8.45e-03	Nonsignificant	—	0.00	Other	0	0
133	FIB.barrier_secretory	6.59e-03	Nonsignificant	1.00	0.34	Other	81	228
134	MG.microglia	6.53e-03	Nonsignificant	—	—	Other	49	0
135	FIB.skin_sheath	6.10e-03	Nonsignificant	1.00	0.23	Other	49	118
136	MAC.resident_cardiac	5.37e-03	Nonsignificant	1.00	0.67	Other	485	1,074
137	MEL.melanocyte	4.64e-03	Nonsignificant	—	—	Other	79	242
138	B.age_associated	4.18e-03	Nonsignificant	1.00	0.58	Other	207	350
139	NEU.EXC_IT	3.82e-03	Nonsignificant	1.00	0.80	Other	411	192
140	MAC.resident_repair	3.34e-03	Nonsignificant	1.00	0.83	Other	796	1,426
141	FIB.skin_tenogenic	2.52e-03	Nonsignificant	—	0.00	Other	108	227
142	MONO.CD16	1.21e-03	Nonsignificant	0.84	0.93	Other	1,304	1,835
143	FIB.skin_papillary	1.07e-03	Nonsignificant	—	0.00	Other	0	0
144	HEP.acute_phase	7.44e-04	Nonsignificant	1.00	0.70	Other	1,441	3,641
145	OPC.oligodendrocyte_precursor_cell	7.29e-04	Nonsignificant	—	—	Other	413	1,269
146	NEU.INH_VIP	6.51e-04	Nonsignificant	1.00	0.72	Other	241	366
147	NEU.INH_LAMP5	1.46e-04	Nonsignificant	1.00	0.54	Other	263	532
148	GRANU.neutrophil	3.81e-05	Nonsignificant	1.00	0.00	Other	1,235	2,649
149	NEU.EXC_CT	8.50e-06	Nonsignificant	1.00	0.28	Other	362	384
150	DC.pDC	5.05e-06	Nonsignificant	1.00	0.26	Other	496	1,028
151	NEU.EXC_SYT2	3.94e-06	Nonsignificant	—	0.00	Other	40	77
152	NEU.EXC_NTNG1	3.16e-06	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.salivary_intercalated_defense.basal_EMT	31.34	Significant	—	2.00	—	0	0
2	EC.venous.remodeling_stalk	29.36	Significant	6.63e-05	2.40	—	559	566
3	EPI.skin_appendage_keratinocyte.transit_amplifying	26.96	Significant	—	1.18	Relevant	109	358
4	EC.venous.quiescent_homeostatic	21.23	Significant	3.84e-03	1.92	—	456	360
5	EC.capillary.postcap_venule	16.90	Significant	0.09	1.54	—	355	261
6	EC.capillary.angiocrine	16.69	Significant	0.07	1.59	Specific	250	630
7	EC.capillary.migratory	15.73	Significant	0.07	1.65	Relevant	181	509
8	EC.arterial.metabolic	15.22	Significant	5.09e-03	1.90	—	195	159
9	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	15.05	Significant	0.70	1.19	—	33	34
10	EC.capillary.angiogenic_tip	14.67	Significant	0.71	1.13	—	186	218
11	CM.mechano_activated	14.60	Significant	0.05	1.84	—	205	134
12	EPI.tracheal_suprabasal.transitional_wound	14.50	Significant	—	0.43	—	16	1
13	EPI.salivary_duct_excretory.stress	14.45	Significant	0.50	1.31	Relevant	33	68
14	EPI.colonocyte.junction_remodeling	14.41	Significant	0.02	1.94	—	218	305
15	EPI.salivary_intercalated_defense.inflammatory	14.14	Significant	0.08	1.67	Relevant	152	360
16	EC.capillary.baseline	14.09	Significant	1.00	0.89	Specific	246	560
17	EC.venous.adipose_lipid	13.82	Significant	1.00	0.84	—	254	476
18	EC.arterial.arteriole_interface	13.75	Significant	0.44	1.31	—	31	12
19	EPI.tracheal_basal.homeostatic_progenitor	13.45	Significant	0.08	1.92	—	285	74
20	EC.venous.baseline	12.99	Significant	1.00	0.55	Specific	346	807
21	CM.mito_proteostasis	12.65	Significant	0.88	1.13	—	329	29
22	CM.translation_boost_RPL	12.31	Significant	0.88	0.97	—	129	1
23	EPI.lung_club_secretory.ciliogenesis_primed	12.28	Significant	—	0.79	—	0	0
24	CM.anti_inflammatory	12.19	Significant	0.88	1.04	Specific	424	1,503
25	CM.oxidative_phospho	12.18	Significant	0.88	1.22	Relevant	266	792
26	CM.translation_boost_RPS	12.17	Significant	0.88	0.79	—	69	16
27	EC.venous.activated	12.14	Significant	1.00	0.53	Relevant	247	752
28	EC.arterial.mito_contact	12.02	Significant	0.74	1.13	—	14	5
29	CM.sarcomere_actin_interface	11.91	Significant	0.88	0.92	—	450	78
30	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	11.68	Significant	0.94	0.36	Relevant	7	16
31	CM.baseline	11.63	Significant	0.88	0.89	—	393	0
32	EC.capillary.stress	11.49	Significant	1.00	0.43	—	44	36
33	EPI.skin_keratinocyte_basal.basement_anchoring	11.40	Significant	—	0.97	Relevant	0	0
34	EPI.renal_principal_cell.inflammatory	11.17	Significant	0.20	1.74	Relevant	74	157
35	EPI.skin_sweat_duct_keratinocyte.proliferative_S	11.11	Significant	—	1.36	Relevant	0	0
36	EPI.lung_club_secretory.canonical_surfactant	10.94	Significant	—	0.49	—	74	104
37	CM.osmoprotection	10.55	Significant	1.00	0.54	Relevant	34	57
38	EC.arterial.arteriole_gas_exchange	10.52	Significant	0.94	0.94	—	238	131
39	EPI.colonocyte.crypt_progenitor	10.44	Significant	0.59	1.22	Relevant	115	265
40	EPI.salivary_duct_excretory.baseline	10.37	Significant	0.92	0.40	Relevant	23	57
41	EC.arterial.inflammatory	10.24	Significant	0.27	1.49	—	63	50
42	EPI.colonocyte.ionocyte_BEST4	9.99	Significant	0.76	1.07	—	103	188
43	EPI.skin_sebaceous_duct_luminal.immune_interface	9.99	Significant	—	1.80	Relevant	0	0
44	EC.capillary.inflammatory	9.92	Significant	1.00	0.06	Relevant	27	51
45	EC.arterial.angiogenic_tip	9.91	Significant	—	0.00	—	30	37
46	EPI.salivary_myoepithelial.junctional_transport	9.74	Significant	0.07	2.04	Relevant	66	121
47	EPI.tracheal_basal.activated_stress	9.40	Significant	0.96	0.12	—	32	0
48	EPI.salivary_myoepithelial.contractile_repair	9.17	Significant	—	0.00	Relevant	3	9
49	EPI.skin_keratinocyte_proliferating.detox_repair	9.16	Significant	—	1.13	Relevant	0	0
50	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	9.05	Significant	—	0.96	Relevant	0	0
51	CM.inflammatory	9.04	Significant	—	0.00	—	0	0
52	EC.arterial.elastic	8.71	Significant	0.94	0.71	—	22	45
53	EC.arterial.homeostatic	8.63	Significant	0.94	0.57	—	24	3
54	EPI.salivary_serous_acinar.secretory_active	8.59	Significant	2.61e-04	2.60	—	242	69
55	SKM.type_1_slow.oxidative	8.37	Significant	5.11e-03	2.21	Specific	802	251
56	EPI.salivary_myoepithelial.activated	8.22	Significant	0.98	0.66	Relevant	85	281
57	EPI.renal_principal_cell.activated_acute	8.06	Significant	0.82	1.20	Relevant	29	59
58	EPI.tracheal_suprabasal.secretory_immune	8.02	Significant	—	0.00	Relevant	0	0
59	EPI.lung_club_secretory.inflammatory	7.91	Significant	—	0.00	Relevant	0	0
60	EPI.colonocyte.goblet_interface	7.81	Significant	—	0.00	Relevant	11	21
61	SKM.type_1_slow.contractile	7.70	Significant	0.18	1.45	—	596	8
62	EPI.salivary_myoepithelial.baseline	7.28	Significant	0.98	0.17	Relevant	42	141
63	EC.arterial.ion_pump	7.27	Significant	0.94	0.36	—	3	2
64	EPI.colonocyte.proximal_transport	7.03	Significant	1.00	0.39	—	24	12
65	EPI.renal_distal_tubule.stress	6.98	Significant	—	1.02	Relevant	0	0
66	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	6.91	Significant	—	0.00	—	39	82
67	EPI.renal_intercalated_cell_type_A.PC_transitional	6.91	Significant	—	0.94	Relevant	203	407
68	EC.capillary.activated	6.64	Significant	1.00	0.09	—	2	5
69	EPI.salivary_intercalated_defense.canonical_antimicrobial	6.50	Significant	1.00	0.00	—	11	22
70	EC.venous.cardiac_structural	6.44	Significant	1.00	0.06	—	102	229
71	EPI.renal_distal_tubule.ion_transport	5.94	Significant	—	0.40	Other	0	0
72	EPI.thymic_cortical.baseline	5.82	Significant	0.05	1.86	Relevant	185	386
73	EPI.thymic_cortical.Notch_interface	5.67	Significant	—	0.03	Relevant	82	137
74	EPI.renal_principal_cell.intercalated_like	5.48	Nominal	0.96	0.79	Other	63	66
75	EPI.pancreatic_ductal_progenitor.ADM_like	5.43	Nominal	—	1.55	Other	0	0
76	EPI.renal_immature_ureteric_bud.osmoprotective	5.27	Nominal	0.40	1.12	Other	126	44
77	EPI.renal_immature_ureteric_bud.defense_secretory	5.23	Nominal	0.40	1.09	Other	45	76
78	OLG.regulatory	5.08	Nominal	5.95e-18	2.74	Other	353	73
79	EPI.salivary_serous_acinar.quiescent	5.05	Nominal	1.00	0.07	Other	178	493
80	OLG.regulatory_activated	5.04	Nominal	1.68e-06	2.37	Other	196	614
81	EPI.renal_distal_tubule.immune_modulatory	5.01	Nominal	—	0.46	Other	0	0
82	EPI.skin_hair_follicle_bulge.niche_crosstalk	4.99	Nominal	—	0.32	Other	29	88
83	EPI.colonocyte.secretory_boost	4.81	Nominal	1.00	0.04	Other	98	91
84	PERI.angiocrine	4.75	Nominal	1.30e-03	1.87	Other	93	102
85	EPI.skin_sweat_duct_keratinocyte.signal_gate	4.70	Nominal	—	0.28	Other	43	26
86	EPI.salivary_mucous_acinar.baseline	4.70	Nominal	—	—	Other	394	683
87	EPI.renal_principal_cell.canonical_vasopressin	4.69	Nominal	0.96	0.34	Other	2	0
88	EPI.cervical_suprabasal.secretory_vesicle	4.69	Nominal	—	0.00	Other	0	0
89	EPI.pancreatic_acinar.adhesion_remodeling	4.66	Nominal	0.14	1.45	Other	210	784
90	PLAT.megakaryocytic	4.51	Nominal	—	0.97	Other	0	0
91	EPI.renal_thick_ascending_limb.barrier_repair	4.43	Nominal	4.20e-05	1.98	Other	141	284
92	PERI.inflammatory	4.32	Nominal	0.01	1.57	Other	40	77
93	EPI.endocervical_secretory.squamous_barrier	4.24	Nominal	—	0.67	Other	0	0
94	EPI.pancreatic_acinar.metabolic_onecarbon	4.20	Nominal	0.03	1.56	Other	287	328
95	SKM.type_1_slow.glycolytic	4.19	Nominal	1.00	0.00	Other	362	647
96	PERI.baseline	4.11	Nominal	0.03	1.50	Other	39	66
97	EPI.salivary_serous_acinar.seromucous_like	4.03	Nominal	—	0.00	Other	0	0
98	EPI.salivary_duct_ion_transport.baseline	3.99	Nominal	—	—	Other	0	0
99	EPI.renal_intercalated_cell_type_A.acid_secretion	3.96	Nominal	1.00	0.00	Other	12	6
100	EPI.skin_hair_follicle_bulge.quiescent	3.94	Nominal	0.58	0.90	Other	56	69
101	EPI.skin_hair_follicle_bulge.anagen_growth	3.93	Nominal	—	0.00	Other	0	0
102	EPI.cervical_suprabasal.inflammatory_repair	3.68	Nominal	—	0.00	Other	0	0
103	EPI.pancreatic_acinar.stress	3.65	Nominal	0.43	1.19	Other	28	28
104	EC.heart_remodeling.remodeling_secretory	3.64	Nominal	6.06e-04	1.63	Other	605	1,341
105	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	3.58	Nominal	—	1.15	Other	0	0
106	EPI.renal_principal_cell.injury_repair	3.51	Nominal	0.96	0.22	Other	26	9
107	OLG.vesicle_trafficking	3.44	Nominal	1.00	0.89	Other	124	10
108	EC.heart_remodeling.capillary_metabolic	3.28	Nominal	0.29	1.44	Other	54	414
109	OLG.stress	3.24	Nominal	1.00	0.69	Other	232	8
110	EPI.ectocervical_granular.proliferative_basal	3.17	Nominal	—	1.15	Other	0	0
111	EPI.pancreatic_ductal_progenitor.baseline	3.16	Nominal	0.11	1.55	Other	179	702
112	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	3.12	Nominal	0.05	1.79	Other	449	1,034
113	EPI.thymic_cortical.secretory_remodeling	3.03	Nominal	—	0.00	Other	4	1
114	OLG.myelinating_stress	2.86	Nonsignificant	1.00	0.55	Other	232	62
115	EPI.esophageal_suprabasal.basal_transitional	2.75	Nonsignificant	9.89e-03	2.32	Other	44	67
116	OLG.myelinating_mature	2.69	Nonsignificant	1.00	0.14	Other	363	94
117	EPI.skin_follicular_keratinizing.transit_amplifying	2.64	Nonsignificant	—	0.74	Other	21	49
118	EPI.esophageal_basal.junctional_barrier	2.60	Nonsignificant	—	1.01	Other	0	0
119	CHOND.pro_inflammatory	2.53	Nonsignificant	3.62e-03	1.55	Other	181	351
120	EPI.endocervical_secretory.secretory_translocon	2.51	Nonsignificant	—	0.00	Other	0	0
121	SMC.metabolic	2.50	Nonsignificant	4.89e-03	1.78	Other	14	40
122	EPI.skin_keratinocyte_proliferating.anchor_remodel	2.46	Nonsignificant	—	0.18	Other	0	0
123	EC.heart_remodeling.remodeling_stalk	2.45	Nonsignificant	0.97	1.02	Other	33	111
124	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	2.42	Nonsignificant	0.78	1.05	Other	2	9
125	OLG.reactive_repair	2.27	Nonsignificant	1.00	0.09	Other	385	385
126	EPI.esophageal_suprabasal.proliferative_S	2.26	Nonsignificant	—	0.54	Other	26	41
127	EPI.colonocyte.distal_absorptive	2.26	Nonsignificant	—	0.00	Other	0	0
128	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.24	Nonsignificant	—	0.00	Other	0	0
129	EPI.skin_keratinocyte_basal.transit_amplifying	2.24	Nonsignificant	—	0.00	Other	0	0
130	EPI.esophageal_suprabasal.proliferative_exit	2.23	Nonsignificant	—	0.73	Other	0	0
131	EPI.pancreatic_acinar.baseline	2.21	Nonsignificant	1.00	0.46	Other	274	163
132	EPI.gastric_foveolar.baseline	2.09	Nonsignificant	—	0.00	Other	0	0
133	ADIPO.hypoxia_remodelling	2.07	Nonsignificant	—	0.63	Other	29	105
134	EPI.skin_interfollicular_spinous.proliferative	2.07	Nonsignificant	—	1.47	Other	0	0
135	EPI.lung_multiciliated.stress	1.95	Nonsignificant	—	0.77	Other	67	165
136	EPI.esophageal_basal.activated_progenitor	1.94	Nonsignificant	1.00	0.00	Other	1	0
137	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.93	Nonsignificant	—	0.00	Other	0	0
138	EPI.ileal_enterocyte_crypt.proliferative_S	1.86	Nonsignificant	0.43	1.37	Other	4	2
139	PERI.cardiac_skeletal	1.83	Nonsignificant	1.00	0.01	Other	313	630
140	EPI.skin_sebaceous_duct_luminal.detox_repair	1.80	Nonsignificant	0.78	0.56	Other	137	94
141	EC.heart_remodeling.translation_boost	1.79	Nonsignificant	—	0.37	Other	0	0
142	EPI.renal_intercalated_cell_type_B.baseline	1.76	Nonsignificant	—	0.00	Other	3	1
143	EPI.skin_interfollicular_spinous.transition_basal	1.71	Nonsignificant	6.83e-03	1.64	Other	100	127
144	EPI.esophageal_suprabasal.proliferative_G2M	1.71	Nonsignificant	—	0.04	Other	0	0
145	EPI.renal_thick_ascending_limb.remodeling	1.69	Nonsignificant	0.95	1.10	Other	152	92
146	CM.contractile_oxphos	1.64	Nonsignificant	1.00	0.00	Other	6	19
147	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.64	Nonsignificant	—	0.00	Other	135	290
148	EPI.skin_follicular_keratinizing.upper_infundibulum	1.59	Nonsignificant	—	0.00	Other	8	2
149	EPI.lung_multiciliated.baseline	1.57	Nonsignificant	—	0.00	Other	0	7
150	EPI.esophageal_suprabasal.differentiating_keratin	1.56	Nonsignificant	1.00	0.00	Other	131	61
151	EPI.pancreatic_ductal_progenitor.ciliated_transport	1.55	Nonsignificant	—	0.00	Other	105	368
152	SMC.activated	1.54	Nonsignificant	1.00	0.87	Other	2	5
153	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.51	Nonsignificant	—	0.00	Other	0	0
154	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.48	Nonsignificant	—	0.00	Other	0	0
155	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	1.48	Nonsignificant	—	0.00	Other	0	0
156	EPI.skin_keratinocyte_progenitor.activated_stress	1.45	Nonsignificant	—	0.00	Other	0	0
157	EPI.ileal_enterocyte_crypt.baseline	1.43	Nonsignificant	0.43	1.12	Other	11	6
158	EPI.hepatic_ductular_cholangiocyte.stress	1.39	Nonsignificant	—	1.86	Other	0	0
159	EC.lymphatic.tip_migratory	1.38	Nonsignificant	0.33	1.39	Other	23	37
160	EC.lymphatic.valve	1.38	Nonsignificant	—	0.77	Other	0	0
161	EC.heart_remodeling.perivascular	1.35	Nonsignificant	1.00	0.76	Other	124	408
162	EPI.pancreatic_acinar.quiet_dedifferentiation	1.32	Nonsignificant	1.00	0.27	Other	142	171
163	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.30	Nonsignificant	—	0.00	Other	0	0
164	HEP.periportal_metabolic.stress_chaperone	1.30	Nonsignificant	—	1.06	Other	66	128
165	EPI.tracheal_submucosal_gland.ductal_luminal	1.29	Nonsignificant	—	0.73	Other	0	0
166	B.memory.preactivated	1.27	Nonsignificant	0.07	1.16	Other	173	174
167	CHOND.articular_collagen	1.27	Nonsignificant	0.18	1.20	Other	551	266
168	T.CD4_Th2.tissue_adapted	1.26	Nonsignificant	—	0.97	Other	0	0
169	B.naive.restrained	1.24	Nonsignificant	1.00e-03	1.21	Other	183	353
170	EPI.lung_club_secretory.ciliogenesis_axoneme	1.22	Nonsignificant	—	0.00	Other	0	0
171	SMC.contractile	1.19	Nonsignificant	1.00	0.21	Other	80	588
172	EPI.alveolar_type_2.baseline_surfactant	1.16	Nonsignificant	0.28	1.17	Other	64	9
173	EPI.ileal_enterocyte_crypt.bile_transport	1.16	Nonsignificant	0.43	1.10	Other	2	0
174	EPI.skin_sweat_duct_keratinocyte.repair	1.07	Nonsignificant	—	0.00	Other	0	0
175	EPI.skin_keratinocyte_basal.spinous_transition	1.06	Nonsignificant	—	0.00	Other	0	0
176	EC.lymphatic.activated	1.05	Nonsignificant	0.33	1.40	Other	47	73
177	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.04	Nonsignificant	—	0.00	Other	0	0
178	EPI.skin_follicular_keratinizing.root_infundibulum	1.03	Nonsignificant	—	0.00	Other	0	0
179	EPI.ileal_bile_transport.detox_transcytosis	1.01	Nonsignificant	—	1.18	Other	0	1
180	NEU.INH_PVALB.neuromodulatory	0.99	Nonsignificant	—	0.90	Other	0	0
181	EC.lymphatic.baseline	0.98	Nonsignificant	0.56	1.08	Other	38	72
182	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.98	Nonsignificant	1.00	0.46	Other	322	317
183	EPI.ileal_enterocyte_absorptive.brush_border	0.98	Nonsignificant	2.27e-04	2.38	Other	580	1,717
184	EPI.alveolar_type_2.stress_response	0.95	Nonsignificant	0.07	1.41	Other	675	1,562
185	T.CD4_Tfh.canonical_GC_helper	0.93	Nonsignificant	0.65	1.27	Other	1	2
186	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.91	Nonsignificant	—	0.77	Other	11	69
187	EPI.alveolar_type_1.activated	0.91	Nonsignificant	—	1.64	Other	0	0
188	EPI.colonic_tuft.homeostatic	0.91	Nonsignificant	—	0.00	Other	0	0
189	EPI.thymic_medullary.proliferative_APC	0.88	Nonsignificant	—	1.09	Other	0	0
190	CHOND.angiogenic	0.88	Nonsignificant	—	0.35	Other	0	0
191	EPI.colonic_tuft.activated	0.87	Nonsignificant	—	0.00	Other	0	0
192	EPI.renal_thick_ascending_limb.cation_flux	0.86	Nonsignificant	1.00	0.38	Other	57	95
193	NEU.INH_PVALB.fastspike	0.86	Nonsignificant	—	0.98	Other	24	22
194	EPI.skin_hair_follicle_companion.activated_migratory	0.84	Nonsignificant	—	0.97	Other	0	0
195	T.CD4_Tfh.effector_migratory	0.84	Nonsignificant	0.74	1.10	Other	122	57
196	T.CD4_naive.neddylation_mitoprot	0.81	Nonsignificant	0.28	1.50	Other	93	56
197	EPI.thymic_medullary.hormone_xeno_barrier	0.79	Nonsignificant	—	0.53	Other	0	8
198	EPI.ileal_goblet.immature	0.77	Nonsignificant	—	1.59	Other	0	0
199	T.CD4_Tfh.suppression_exhaustion	0.76	Nonsignificant	0.75	0.97	Other	0	2
200	ASPC.inflammatory	0.76	Nonsignificant	7.26e-03	1.61	Other	21	61
201	T.CD4_Treg.Tr1_like	0.75	Nonsignificant	—	0.82	Other	8	8
202	NEU.INH_PVALB.serotonergic	0.75	Nonsignificant	—	0.91	Other	0	0
203	EPI.skin_interfollicular_spinous.stress_oxidative	0.74	Nonsignificant	—	0.53	Other	0	0
204	NK.cytokine_biosynthetic_primed	0.73	Nonsignificant	0.02	1.79	Other	360	21
205	EPI.thymic_medullary.stress_APC	0.73	Nonsignificant	1.00	1.02	Other	2	4
206	EPI.alveolar_type_1.baseline	0.71	Nonsignificant	1.00	0.00	Other	8	0
207	EPI.ileal_bile_transport.absorptive_xenobiotic	0.70	Nonsignificant	1.00	0.00	Other	11	12
208	EPI.renal_proximal_tubule.detox_antioxidant	0.70	Nonsignificant	0.06	2.22	Other	394	77
209	T.CD4_Tcm.baseline	0.69	Nonsignificant	0.12	1.46	Other	61	31
210	T.CD4_Th17.baseline	0.69	Nonsignificant	0.78	1.25	Other	51	5
211	ADIPO.thermogenic	0.66	Nonsignificant	—	0.78	Other	0	0
212	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.66	Nonsignificant	0.75	0.59	Other	58	89
213	FIB.lung_alveolar.mito_secretory	0.65	Nonsignificant	—	0.48	Other	0	0
214	NK.cytokine_axis_baseline	0.64	Nonsignificant	2.79e-08	1.89	Other	1,172	116
215	EPI.renal_thick_ascending_limb.salt_sensing	0.64	Nonsignificant	1.00	0.11	Other	73	103
216	EPI.renal_distal_tubule.repair	0.64	Nonsignificant	—	0.00	Other	34	102
217	EPI.lung_multiciliated.mature_motile_cilia	0.64	Nonsignificant	—	0.00	Other	0	0
218	T.CD4_Tcm.stress	0.63	Nonsignificant	0.22	1.50	Other	5	11
219	EPI.skin_interfollicular_spinous.inflammatory	0.63	Nonsignificant	—	0.29	Other	0	0
220	EPI.ileal_enterocyte_crypt.villus_transition	0.63	Nonsignificant	—	0.00	Other	7	10
221	NK.cytokine_repair_primed	0.62	Nonsignificant	0.23	1.46	Other	266	11
222	T.CD4_Treg.central_naive_like	0.60	Nonsignificant	0.35	1.36	Other	333	45
223	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.59	Nonsignificant	—	0.00	Other	19	54
224	NK.cytokine_vascular_patrolling	0.59	Nonsignificant	0.19	1.35	Other	863	94
225	EPI.renal_distal_tubule.ciliated_remodelling	0.58	Nonsignificant	—	0.00	Other	0	0
226	FIB.tracheal_subepithelial.baseline	0.58	Nonsignificant	—	0.00	Other	0	0
227	EC.heart_remodeling.activated_acute	0.56	Nonsignificant	1.00	0.27	Other	102	186
228	FIB.lung_alveolar.stress_interacting	0.56	Nonsignificant	—	0.00	Other	0	0
229	EC.lymphatic.scavenger	0.55	Nonsignificant	0.99	0.11	Other	203	257
230	NK.adaptive_biosynthetic_primed	0.55	Nonsignificant	1.00	0.99	Other	244	405
231	T.CD4_Tcm.Tfh_like	0.55	Nonsignificant	0.89	1.09	Other	102	214
232	T.CD4_naive.homeostatic	0.54	Nonsignificant	0.28	1.38	Other	215	108
233	NK.cytokine_quiescent	0.51	Nonsignificant	0.46	1.24	Other	623	1,062
234	FIB.barrier_purinergic.lipid_secretory	0.51	Nonsignificant	—	0.48	Other	0	0
235	SKM.type_2_fast.oxidative_IIa	0.51	Nonsignificant	0.50	1.22	Other	946	56
236	EPI.ileal_enterocyte_absorptive.villus_tip	0.51	Nonsignificant	1.00	0.00	Other	4	3
237	SKM.type_2_fast.glycolytic_IIx_IIb	0.51	Nonsignificant	0.51	1.01	Other	565	1,482
238	T.CD4_Tcm.imprinted_splicing	0.50	Nonsignificant	0.81	1.23	Other	6	17
239	EC.heart_remodeling.angiocrine	0.50	Nonsignificant	1.00	0.09	Other	182	525
240	T.CD4_Tcm.RNA_control	0.50	Nonsignificant	0.89	1.06	Other	96	4
241	HPC.LMPP	0.50	Nonsignificant	0.16	1.28	Other	65	31
242	T.CD4_naive.purinergic	0.49	Nonsignificant	0.64	1.17	Other	49	1
243	T.CD4_Treg.APC_interactive	0.49	Nonsignificant	0.79	0.76	Other	118	28
244	ADIPO.inflammatory	0.49	Nonsignificant	—	0.00	Other	0	0
245	T.CD4_naive.survival	0.48	Nonsignificant	0.64	1.11	Other	12	17
246	T.CD4_Tcm.secretory	0.48	Nonsignificant	0.81	1.19	Other	20	11
247	NK.immature_bridge	0.46	Nonsignificant	1.00	0.78	Other	117	122
248	T.CD4_naive.mature_mitoprot	0.46	Nonsignificant	0.64	1.08	Other	212	476
249	EPI.ileal_enterocyte_crypt.secretory_precursor	0.46	Nonsignificant	—	0.00	Other	0	0
250	NK.adaptive_classII_inhibitory	0.45	Nonsignificant	1.00	0.80	Other	880	154
251	T.CD4_naive.survival_mitoprot	0.45	Nonsignificant	0.64	1.11	Other	13	7
252	EPI.skin_interfollicular_spinous.early_differentiation	0.45	Nonsignificant	0.97	0.55	Other	89	19
253	NK.adaptive_HLAE_tuned	0.45	Nonsignificant	1.00	0.56	Other	1,124	189
254	NK.adaptive_axis_baseline	0.45	Nonsignificant	1.00	0.72	Other	1,008	153
255	T.CD4_naive.neddylation	0.44	Nonsignificant	0.64	1.06	Other	104	222
256	ASPC.adipocyte_capillary_interface	0.44	Nonsignificant	0.59	1.14	Other	21	54
257	ASPC.remodeling	0.44	Nonsignificant	0.22	1.27	Other	106	354
258	CHOND.activated_fibro_like	0.43	Nonsignificant	1.00	0.21	Other	531	188
259	ASPC.preadipocyte_lipid_primed	0.43	Nonsignificant	4.66e-04	1.41	Other	331	129
260	T.CD4_naive.Treg_like	0.43	Nonsignificant	0.64	1.26	Other	121	72
261	T.CD4_naive.mature	0.41	Nonsignificant	1.00	0.74	Other	211	100
262	T.CD4_Treg.tissue_effector	0.40	Nonsignificant	0.79	0.80	Other	16	13
263	EPI.thymic_medullary.canonical_alarmin	0.40	Nonsignificant	1.00	0.00	Other	8	17
264	T.CD4_Tcm.Th2_like	0.40	Nonsignificant	0.10	1.67	Other	23	55
265	EPI.ileal_goblet.baseline	0.40	Nonsignificant	0.61	1.23	Other	16	2
266	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.40	Nonsignificant	—	0.73	Other	0	0
267	B.naive.activated	0.40	Nonsignificant	1.00	0.98	Other	77	127
268	ASPC.activated	0.37	Nonsignificant	0.79	1.03	Other	164	162
269	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.37	Nonsignificant	—	0.00	Other	0	0
270	T.CD4_naive.survival_neddylation	0.37	Nonsignificant	1.00	0.70	Other	26	38
271	T.CD4_Tcm.crosstalk_myeloid	0.36	Nonsignificant	0.97	0.76	Other	5	4
272	NEU.INH_PVALB.nuclear_reg	0.36	Nonsignificant	1.00	0.83	Other	25	12
273	T.CD4_Tfh.precursor_migratory	0.35	Nonsignificant	0.96	0.57	Other	72	27
274	T.MAIT.stress	0.35	Nonsignificant	—	1.54	Other	0	0
275	HPC.GMP_inflammatory	0.34	Nonsignificant	0.60	1.11	Other	20	10
276	EPI.skin_interfollicular_spinous.baseline	0.34	Nonsignificant	0.97	0.34	Other	35	3
277	EPI.pancreatic_acinar.inflammatory_regenerative	0.34	Nonsignificant	1.00	0.03	Other	25	113
278	EPI.ileal_goblet.inflammatory_mucin	0.34	Nonsignificant	0.84	0.43	Other	6	9
279	EPI.tracheal_submucosal_gland.acinar_serous	0.33	Nonsignificant	—	0.00	Other	0	0
280	FIB.hepatic_stellate_cell.fibrogenic	0.33	Nonsignificant	—	0.42	Other	0	0
281	EPI.ileal_goblet.stress_metallothionein	0.33	Nonsignificant	—	0.00	Other	4	11
282	T.CD4_Tem.transitional_CM	0.33	Nonsignificant	0.39	1.20	Other	31	20
283	T.CD4_Tcm.regulatory_poised	0.33	Nonsignificant	0.97	0.85	Other	2	3
284	NK.adaptive_adipose_stress	0.32	Nonsignificant	1.00	0.46	Other	374	39
285	HPC.CLP_B_primed	0.32	Nonsignificant	—	0.69	Other	0	0
286	B.naive.antigen_presenting_ready	0.32	Nonsignificant	1.00	0.98	Other	48	73
287	T.CD4_Tcm.retro_ZNF117	0.32	Nonsignificant	0.97	0.84	Other	5	9
288	T.CD4_Tcm.APC_mimicry	0.32	Nonsignificant	0.97	0.99	Other	54	43
289	T.CD4_Tcm.migratory_cilium	0.31	Nonsignificant	0.97	0.89	Other	5	10
290	T.CD4_naive.resist_bystander	0.31	Nonsignificant	1.00	0.56	Other	40	25
291	NK.cytokine_tissue_activation	0.31	Nonsignificant	1.00	0.35	Other	267	450
292	T.CD4_transitional.primed_helper_effector	0.31	Nonsignificant	0.10	1.51	Other	19	43
293	EPI.pancreatic_ductal_perivascular.baseline	0.30	Nonsignificant	0.94	0.41	Other	1	5
294	FIB.hepatic_stellate_cell.contractile	0.29	Nonsignificant	—	0.32	Other	0	0
295	PC.IgA_muocsal.plasmablast	0.29	Nonsignificant	0.34	1.35	Other	5	4
296	ASPC.secretory	0.29	Nonsignificant	0.97	0.93	Other	76	5
297	B.memory.activated	0.28	Nonsignificant	0.91	1.03	Other	105	29
298	ASPC.proliferative	0.28	Nonsignificant	0.93	0.93	Other	33	85
299	T.CD8_Trm.inflammatory	0.27	Nonsignificant	3.44e-05	1.59	Other	124	176
300	T.CD4_Tcm.effector_like	0.27	Nonsignificant	1.00	0.65	Other	293	533
301	T.CD4_Tcm.DC_interact	0.27	Nonsignificant	1.00	0.64	Other	72	32
302	B.naive.proteostasis	0.26	Nonsignificant	1.00	0.98	Other	49	69
303	GRNLSA.proliferative_migratory	0.26	Nonsignificant	0.18	1.25	Other	248	292
304	T.CD4_Tcm.synapse_dynamics	0.26	Nonsignificant	0.97	0.77	Other	15	10
305	FIB.interstitial.mesenchymal_regulator	0.26	Nonsignificant	0.25	1.24	Other	4	4
306	T.CD4_naive.proteostasis_mitoprot	0.25	Nonsignificant	1.00	0.36	Other	15	37
307	T.CD4_Tem.long_term_memory	0.25	Nonsignificant	0.47	1.02	Other	314	587
308	EPI.skin_interfollicular_spinous.stress_UPR	0.24	Nonsignificant	—	0.00	Other	0	0
309	T.CD4_Tem.inflammatory	0.24	Nonsignificant	0.47	1.06	Other	28	6
310	FIB.reticular.stress_metallothionein	0.24	Nonsignificant	—	0.66	Other	3	32
311	ASTRO.synaptic_interaction	0.24	Nonsignificant	0.77	1.08	Other	76	334
312	ASTRO.hypoxia_angiogenic	0.23	Nonsignificant	0.77	1.19	Other	5	18
313	NK.adaptive_terminal_cytotoxic	0.23	Nonsignificant	1.00	0.23	Other	485	802
314	IPSC.mesodermal_primed	0.23	Nonsignificant	0.74	1.13	Other	0	0
315	EPI.pancreatic_islet.delta	0.22	Nonsignificant	—	1.64	Other	0	0
316	HEP.canalicular_transport.ductular_like_transition	0.22	Nonsignificant	0.02	1.39	Other	400	87
317	PC.IgG_systemic.stress	0.22	Nonsignificant	—	1.17	Other	1	5
318	NK.cytokine_tissue_resident	0.22	Nonsignificant	0.71	1.19	Other	74	82
319	T.CD4_Th2.precursor	0.22	Nonsignificant	—	0.00	Other	0	0
320	T.gamma_delta.cytotoxic_effector	0.22	Nonsignificant	0.45	1.26	Other	349	109
321	T.CD8_naive.mito_proteostasis	0.22	Nonsignificant	0.40	1.30	Other	428	100
322	T.CD4_Th17.cytotoxic	0.22	Nonsignificant	0.78	0.75	Other	332	123
323	MAC.alveolar.stress_metabolic	0.21	Nonsignificant	0.15	1.59	Other	116	148
324	T.CD4_naive.proteostasis	0.21	Nonsignificant	1.00	0.18	Other	14	9
325	ASPC.baseline	0.21	Nonsignificant	1.00	0.46	Other	363	170
326	T.CD4_transitional.primed_cytotoxic	0.21	Nonsignificant	0.71	1.14	Other	28	30
327	T.CD4_Tcm.tissue_homing	0.21	Nonsignificant	1.00	0.19	Other	78	46
328	T.gamma_delta.central_memory	0.21	Nonsignificant	0.93	0.66	Other	460	919
329	FIB.hepatic_stellate_cell.inflammatory	0.21	Nonsignificant	—	0.00	Other	0	0
330	T.CD8_Tem.TEMRA	0.20	Nonsignificant	1.47e-04	1.81	Other	920	1,088
331	FIB.reticular.stromal_niche	0.20	Nonsignificant	0.09	1.48	Other	0	0
332	MAC.alveolar.biosynthetic_sterol_heme	0.20	Nonsignificant	0.15	1.52	Other	347	40
333	T.gamma_delta.early_effector	0.20	Nonsignificant	0.69	1.02	Other	89	0
334	EPI.colonic_enteroendocrine.progenitor	0.20	Nonsignificant	—	0.97	Other	0	0
335	ILC2.quiescent	0.20	Nonsignificant	—	0.80	Other	0	0
336	ASPC.mesothelial_like	0.19	Nonsignificant	7.26e-03	1.73	Other	143	486
337	T.MAIT.migratory	0.19	Nonsignificant	0.42	1.52	Other	10	1
338	T.CD4_Th17.migratory	0.19	Nonsignificant	0.78	0.66	Other	13	23
339	T.CD8_transitional.stress	0.18	Nonsignificant	—	0.58	Other	24	34
340	MONO.CD14.platelet_bound	0.18	Nonsignificant	0.71	1.13	Other	964	176
341	T.CD4_cytotoxic.baseline	0.17	Nonsignificant	0.17	1.64	Other	0	0
342	T.CD4_Trm.metal_stress	0.17	Nonsignificant	0.56	1.17	Other	34	58
343	T.CD4_Trm.helper_like	0.17	Nonsignificant	0.63	1.05	Other	84	147
344	EPI.skin_sweat_duct_keratinocyte.barrier	0.16	Nonsignificant	—	0.00	Other	0	0
345	T.CD4_Trm.cytotoxic_effector	0.16	Nonsignificant	0.56	1.11	Other	118	77
346	T.CD4_transitional.baseline	0.16	Nonsignificant	0.75	1.03	Other	59	97
347	PC.IgG_systemic.secretory	0.16	Nonsignificant	0.27	1.35	Other	0	0
348	T.MAIT.early_activation	0.16	Nonsignificant	0.77	1.05	Other	57	4
349	T.MAIT.cytotoxic	0.16	Nonsignificant	0.77	1.15	Other	52	15
350	T.MAIT.vesicle	0.16	Nonsignificant	0.77	0.97	Other	37	65
351	NEU.INH_PVALB.metabotropic	0.15	Nonsignificant	—	0.00	Other	0	0
352	PC.IgA_muocsal.activated	0.15	Nonsignificant	0.84	0.98	Other	17	8
353	T.CD8_Tem.baseline	0.15	Nonsignificant	0.95	1.05	Other	458	356
354	MAC.microglia_like.patrolling_adhesive	0.15	Nonsignificant	—	0.69	Other	0	0
355	T.CD4_Trm.baseline	0.14	Nonsignificant	0.63	1.04	Other	31	21
356	HEP.canalicular_transport.secretory_ERAD_UPR	0.14	Nonsignificant	0.91	1.01	Other	232	28
357	HEP.canalicular_transport.injury_stress	0.14	Nonsignificant	0.85	1.07	Other	289	24
358	T.CD8_Trm.muscosal_Tc17	0.14	Nonsignificant	0.28	1.23	Other	19	38
359	THYMO.DN_preTCR	0.14	Nonsignificant	0.07	1.16	Other	41	71
360	FIB.adventitial.PI16_matrix	0.14	Nonsignificant	0.14	1.29	Other	70	90
361	T.CD4_cytotoxic.precursor	0.14	Nonsignificant	0.29	1.41	Other	156	67
362	PC.IgA_muocsal.baseline	0.14	Nonsignificant	0.84	0.83	Other	3	5
363	T.CD4_naive.gut_prone	0.13	Nonsignificant	1.00	0.89	Other	35	70
364	T.CD8_Tcm.gut_homing	0.13	Nonsignificant	0.81	1.20	Other	380	112
365	PC.IgA_muocsal.migratory	0.13	Nonsignificant	0.84	0.92	Other	4	1
366	NEU.INH_PVALB.chandelier	0.13	Nonsignificant	1.00	0.00	Other	19	16
367	T.CD8_Tcm.helper_like	0.13	Nonsignificant	0.81	1.06	Other	81	159
368	T.MAIT.MAPK_brake	0.13	Nonsignificant	0.90	0.77	Other	44	66
369	T.CD8_Tem.early_helper_like	0.13	Nonsignificant	0.95	0.90	Other	445	755
370	T.CD8_Tem.motility_primed	0.13	Nonsignificant	0.95	0.66	Other	269	4
371	MAC.alveolar.lipid_autophagy	0.12	Nonsignificant	—	0.00	Other	35	44
372	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.12	Nonsignificant	—	0.76	Other	2	0
373	NK.cytokine_lung_immediate_early	0.12	Nonsignificant	1.00	0.51	Other	424	274
374	FIB.interstitial.remodeling	0.12	Nonsignificant	0.25	1.15	Other	31	9
375	MAC.alveolar.inflammatory	0.12	Nonsignificant	1.00	0.55	Other	208	312
376	T.CD8_transitional.effector_primed	0.12	Nonsignificant	0.17	1.19	Other	435	151
377	MAC.alveolar.scavenging_endocytic	0.12	Nonsignificant	—	0.00	Other	140	283
378	T.CD8_Trm.cytotoxic	0.12	Nonsignificant	1.00	0.89	Other	165	85
379	T.CD8_transitional.Trm_primed	0.12	Nonsignificant	0.17	1.29	Other	108	15
380	FIB.interstitial.immune_interact	0.12	Nonsignificant	0.33	1.13	Other	12	1
381	CHOND.remodeling	0.12	Nonsignificant	—	0.00	Other	5	0
382	T.CD8_Tem.stress_adapted	0.12	Nonsignificant	0.95	0.67	Other	607	520
383	EPI.skin_interfollicular_spinous.upper_lipid	0.12	Nonsignificant	—	0.00	Other	6	6
384	HPC.MPP_activated	0.11	Nonsignificant	—	0.18	Other	0	0
385	T.CD4_Trm.activated	0.11	Nonsignificant	0.84	0.92	Other	32	26
386	EPI.extrahepatic_cholangiocyte.barrier_interface	0.11	Nonsignificant	—	0.73	Other	0	0
387	T.CD8_Tem.signaling_turnover	0.11	Nonsignificant	0.95	0.72	Other	425	683
388	NK.adaptive_immature_precursor	0.11	Nonsignificant	1.00	0.54	Other	358	111
389	B.germinal_center.DZ_M_phase	0.11	Nonsignificant	—	1.47	Other	0	0
390	T.MAIT.quiescent	0.11	Nonsignificant	0.98	0.38	Other	100	5
391	FIB.adventitial.complement_angiocrine	0.11	Nonsignificant	0.24	1.19	Other	153	684
392	T.CD8_naive.nfkb_related	0.11	Nonsignificant	0.40	1.25	Other	1	0
393	T.CD4_cytotoxic.terminal_effector	0.11	Nonsignificant	0.66	0.88	Other	286	21
394	PC.IgG_systemic.interacting	0.10	Nonsignificant	1.00	0.77	Other	0	0
395	T.CD8_Tcm.effector_bias	0.10	Nonsignificant	0.81	1.02	Other	199	329
396	T.CD4_cytotoxic.activated	0.10	Nonsignificant	0.41	1.25	Other	3	1
397	ILC2.activated	0.10	Nonsignificant	—	0.00	Other	0	0
398	HPC.MPP_IEG	0.10	Nonsignificant	0.84	0.92	Other	45	46
399	HEP.canalicular_transport.pericentral_like_hypoxia	0.10	Nonsignificant	0.92	0.96	Other	326	8
400	T.CD4_Trm.central_like	0.10	Nonsignificant	0.63	1.02	Other	38	31
401	T.CD4_Tem.cytotoxic_effector	0.10	Nonsignificant	0.39	1.24	Other	225	398
402	MAC.microglia_like.inflammatory_chemokine	0.10	Nonsignificant	—	2.22e-04	Other	20	32
403	GRANU.MAST.activated_repair	0.09	Nonsignificant	—	0.22	Other	0	1
404	T.CD4_cytotoxic.NK_adapted	0.09	Nonsignificant	0.66	0.88	Other	82	33
405	FIB.perivascular_interface.vascular_BM_remodelling	0.09	Nonsignificant	—	0.97	Other	0	0
406	HEP.periportal_metabolic.canonical_urea_cycle	0.09	Nonsignificant	0.95	1.03	Other	1,464	269
407	FIB.adventitial.mito_secretory	0.09	Nonsignificant	0.88	1.03	Other	21	7
408	FIB.transitioning.secretory_procollagen	0.09	Nonsignificant	—	0.55	Other	0	0
409	MAC.kupffer.stress	0.09	Nonsignificant	0.35	1.13	Other	9	3
410	FIB.reticular.immune_interface	0.09	Nonsignificant	—	0.00	Other	1	6
411	MUSC.activated_migratory	0.09	Nonsignificant	0.04	1.77	Other	6	7
412	DC.cDC2.lipid_metabolic	0.09	Nonsignificant	—	2.33	Other	0	0
413	MAC.kupffer.tolerogenic	0.09	Nonsignificant	—	0.99	Other	45	49
414	T.CD8_transitional.early	0.09	Nonsignificant	1.00	0.89	Other	327	55
415	FIB.adventitial.inflammatory_activated	0.09	Nonsignificant	0.55	1.11	Other	100	473
416	T.CD8_naive.baseline	0.09	Nonsignificant	0.40	1.13	Other	142	2
417	FIB.barrier_purinergic.stress_GF_binding	0.08	Nonsignificant	—	0.00	Other	0	0
418	HEP.periportal_metabolic.xenobiotic_detox	0.08	Nonsignificant	0.95	1.02	Other	1,440	139
419	MAC.LAM.perivascular_angiocrine	0.08	Nonsignificant	—	0.88	Other	53	138
420	DC.mig.baseline	0.08	Nonsignificant	—	0.00	Other	1	0
421	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.08	Nonsignificant	0.42	1.20	Other	219	533
422	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.07	Nonsignificant	—	0.42	Other	0	0
423	GRANU.MAST.resting_granule	0.07	Nonsignificant	—	0.13	Other	0	0
424	MAC.resident_iron.redox_metabolic	0.07	Nonsignificant	0.19	1.32	Other	4	4
425	T.CD8_naive.cytokine_dampened	0.07	Nonsignificant	0.96	0.92	Other	71	4
426	HPC.GMP_granulocytic	0.07	Nonsignificant	—	0.00	Other	3	3
427	GRNLSA.angiocrine_mechanosensory	0.07	Nonsignificant	—	0.89	Other	0	0
428	ADIPO.immature	0.07	Nonsignificant	—	0.00	Other	24	40
429	MUSC.quiescent_reservoir	0.06	Nonsignificant	0.51	1.25	Other	2	8
430	IPSC.mesendo_primed	0.06	Nonsignificant	0.65	1.08	Other	0	0
431	HEP.canalicular_transport.baseline	0.06	Nonsignificant	0.98	0.83	Other	199	477
432	FIB.adventitial.mechano_chemo_sensing	0.06	Nonsignificant	1.00	0.79	Other	135	524
433	DC.cDC1.activated	0.06	Nonsignificant	—	1.21	Other	0	0
434	EPI.alveolar_type_2.injury_primed	0.06	Nonsignificant	1.00	0.05	Other	434	245
435	EPI.ectocervical_granular.inflammatory	0.06	Nonsignificant	—	0.32	Other	0	0
436	PLAT.adhesion	0.06	Nonsignificant	—	0.00	Other	0	0
437	T.CD4_transitional.APC_interacting	0.06	Nonsignificant	1.00	0.37	Other	10	14
438	GRNLSA.chemokine_mechanosensory	0.06	Nonsignificant	1.00	1.02	Other	1	0
439	T.CD8_naive.effector_transition	0.06	Nonsignificant	0.40	1.19	Other	35	62
440	T.CD8_Trm.homeostatic	0.06	Nonsignificant	1.00	0.43	Other	42	5
441	B.naive.baseline	0.06	Nonsignificant	1.00	0.67	Other	10	13
442	MESO.secretory_structural	0.06	Nonsignificant	—	0.77	Other	0	0
443	B.naive.metabolic	0.06	Nonsignificant	1.00	0.63	Other	50	79
444	T.CD8_naive.splicing_enriched	0.05	Nonsignificant	0.96	0.73	Other	120	16
445	EPI.ectocervical_granular.secretory_apocrine	0.05	Nonsignificant	—	0.00	Other	0	0
446	T.CD8_naive.innate_like	0.05	Nonsignificant	0.96	0.72	Other	10	1
447	B.naive.remodeling	0.05	Nonsignificant	1.00	0.68	Other	135	230
448	T.CD8_naive.vesicle_secretory	0.05	Nonsignificant	0.96	0.95	Other	42	0
449	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.05	Nonsignificant	—	0.00	Other	0	0
450	DC.cDC1.cross_presenting	0.05	Nonsignificant	—	0.32	Other	0	0
451	MEL.neurotrophic_migratory	0.05	Nonsignificant	—	1.24	Other	0	0
452	MONO.CD14.remodeling	0.04	Nonsignificant	0.71	1.06	Other	2,373	295
453	GRANU.MAST.activated_acute	0.04	Nonsignificant	—	0.00	Other	0	0
454	MUSC.early_activation	0.04	Nonsignificant	0.88	0.54	Other	4	32
455	FIB.interstitial.stress_secretory	0.04	Nonsignificant	0.89	0.97	Other	92	56
456	T.CD8_transitional.APC_like	0.04	Nonsignificant	1.00	0.51	Other	205	62
457	FIB.suburothelial.urothelial_interface	0.04	Nonsignificant	2.34e-04	1.53	Other	9	8
458	IPSC.axial_identity_primed	0.04	Nonsignificant	1.00	0.99	Other	0	0
459	MAC.resident_iron.stress_tolerogenic	0.04	Nonsignificant	—	0.92	Other	0	0
460	FIB.perivascular_interface.vasomotor_tone	0.04	Nonsignificant	—	0.00	Other	0	0
461	T.CD8_Tcm.baseline	0.04	Nonsignificant	1.00	0.51	Other	90	89
462	THYMO.SP_CD8_naive_stress	0.04	Nonsignificant	1.00	1.06	Other	1	1
463	FIB.adventitial.adhesion_lipid	0.04	Nonsignificant	1.00	0.54	Other	58	209
464	MAC.alveolar.capillary_interacting	0.04	Nonsignificant	1.00	0.00	Other	113	181
465	EPI.pancreatic_islet.beta	0.04	Nonsignificant	0.51	1.05	Other	42	57
466	MUSC.baseline	0.04	Nonsignificant	0.88	0.56	Other	0	0
467	EPI.pancreatic_islet.alpha	0.04	Nonsignificant	—	0.20	Other	152	330
468	FIB.interstitial.mesenchymal_APC	0.04	Nonsignificant	1.00	0.76	Other	81	33
469	HEP.canalicular_transport.inflammatory	0.04	Nonsignificant	1.00	0.40	Other	1,335	194
470	MAC.LAM.lipid_opsonization	0.04	Nonsignificant	0.03	1.31	Other	45	14
471	T.CD8_Trm.dendritic_recruiter	0.04	Nonsignificant	1.00	0.32	Other	47	85
472	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.04	Nonsignificant	—	0.00	Other	0	0
473	B.memory.baseline	0.04	Nonsignificant	1.00	0.71	Other	472	99
474	FIB.transitioning.ISG_primed_interface	0.04	Nonsignificant	—	0.25	Other	17	80
475	MONO.CD14.baseline	0.03	Nonsignificant	0.90	1.00	Other	2,268	76
476	T.CD8_naive.lipid_synthesis	0.03	Nonsignificant	0.96	0.73	Other	6	4
477	EC.liver_sinusoidal.prostanoid	0.03	Nonsignificant	—	0.71	Other	11	64
478	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.03	Nonsignificant	—	0.00	Other	0	0
479	MAC.MDM.APC_dendritic	0.03	Nonsignificant	0.56	1.20	Other	48	15
480	IPSC.proliferative	0.03	Nonsignificant	1.00	0.99	Other	0	0
481	B.naive.purinergic	0.03	Nonsignificant	1.00	0.50	Other	384	820
482	HEP.pericentral_lipoprotein.ApoB_coagulation	0.03	Nonsignificant	—	0.67	Other	0	0
483	B.naive.receptor_recycle	0.03	Nonsignificant	1.00	0.61	Other	51	0
484	ASPC.niche_keeping_progenitor	0.03	Nonsignificant	1.00	0.07	Other	52	219
485	SCHWN.translation_boost	0.03	Nonsignificant	—	0.27	Other	8	1
486	DC.cDC1.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
487	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.03	Nonsignificant	—	1.05	Other	0	0
488	MONO.CD16.platelet_bound	0.03	Nonsignificant	0.15	1.23	Other	372	508
489	FIB.adventitial.baseline	0.03	Nonsignificant	1.00	0.31	Other	157	278
490	FIB.transitioning.matrix_stress	0.03	Nonsignificant	—	0.00	Other	47	138
491	T.CD4_Trm.stress_adaptive	0.03	Nonsignificant	0.96	0.68	Other	8	22
492	T.CD4_transitional.tissue_enagement	0.03	Nonsignificant	1.00	0.06	Other	5	11
493	GRNLSA.secretory_remodeling	0.03	Nonsignificant	1.00	0.90	Other	90	25
494	EC.liver_sinusoidal.hypoxia_metabolic	0.03	Nonsignificant	0.06	1.36	Other	183	107
495	FIB.reticular.ECM_builder	0.03	Nonsignificant	—	0.00	Other	0	0
496	DC.cDC1.homeostatic_inhibitory	0.02	Nonsignificant	—	0.00	Other	0	0
497	HEP.pericentral_lipoprotein.UPR_redox	0.02	Nonsignificant	—	0.00	Other	0	0
498	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.02	Nonsignificant	—	0.00	Other	0	0
499	FIB.transitioning.motility_remodelling	0.02	Nonsignificant	—	0.00	Other	0	0
500	MESO.antiviral	0.02	Nonsignificant	—	0.33	Other	3	8
501	MAC.LAM.inflammatory_APC	0.02	Nonsignificant	0.04	1.15	Other	872	165
502	SCHWN.reactive_inflammatory	0.02	Nonsignificant	—	0.73	Other	0	0
503	FIB.neurolectin_mucosa.remodeling_repair	0.02	Nonsignificant	—	0.54	Other	4	2
504	HEP.periportal_metabolic.acute_phase_barrier	0.02	Nonsignificant	0.95	0.94	Other	533	138
505	MAC.proliferating.stress	0.02	Nonsignificant	—	0.21	Other	87	136
506	DC.cDC1.proliferative	0.02	Nonsignificant	—	0.00	Other	0	0
507	ILC2.migratory	0.02	Nonsignificant	—	0.00	Other	0	0
508	MAC.MDM.inflammatory_phagocytic	0.02	Nonsignificant	0.90	1.03	Other	199	52
509	NEU.EXC_IT.structural	0.02	Nonsignificant	0.64	1.16	Other	171	41
510	THYMO.proliferative_S	0.02	Nonsignificant	1.00	0.98	Other	163	418
511	EPI.pancreatic_ductal_bicarbonate.stress	0.02	Nonsignificant	—	0.83	Other	12	33
512	B.memory.migratory	0.02	Nonsignificant	1.00	0.74	Other	123	208
513	PC.IgG_systemic.metabolic	0.02	Nonsignificant	1.00	0.00	Other	46	63
514	EPI.colonic_enteroendocrine.Lcell_peptide	0.01	Nonsignificant	—	0.00	Other	0	0
515	FIB.perivascular_interface.lipid_shuttle	0.01	Nonsignificant	—	0.00	Other	51	170
516	DC.cDC2.tolerogenic_regulatory	0.01	Nonsignificant	0.89	1.04	Other	44	4
517	HEP.periportal_metabolic.urea_onecarbon_secretory	0.01	Nonsignificant	0.95	0.98	Other	1,332	3,053
518	MAC.resident_iron.heme_catabolism	0.01	Nonsignificant	0.76	0.83	Other	30	51
519	EPI.ectocervical_granular.immune_interact	0.01	Nonsignificant	—	0.00	Other	0	0
520	MAC.resident_iron.APC_iron_sensing	0.01	Nonsignificant	0.54	1.08	Other	211	114
521	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.01	Nonsignificant	—	0.40	Other	6	9
522	FIB.neurolectin_mucosa.inflammatory	0.01	Nonsignificant	0.30	1.40	Other	52	110
523	DC.cDC2.pro_inflammatory	0.01	Nonsignificant	0.89	1.04	Other	3	5
524	FIB.neurolectin_mucosa.nerve_interface	0.01	Nonsignificant	—	0.00	Other	4	0
525	DC.cDC2.proliferative	0.01	Nonsignificant	—	0.64	Other	39	71
526	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.01	Nonsignificant	—	0.00	Other	0	0
527	FIB.skin_sheath.neuro_vascular_interface	0.01	Nonsignificant	—	0.80	Other	0	0
528	FIB.neurolectin_mucosa.axon_responsive	0.01	Nonsignificant	0.48	1.05	Other	10	10
529	FIB.barrier_secretory.homeostasis	0.01	Nonsignificant	—	0.43	Other	0	0
530	FIB.interstitial.lipid_matrix	0.01	Nonsignificant	1.00	0.31	Other	258	191
531	MAC.proliferating.DNA_replication	9.58e-03	Nonsignificant	0.86	0.71	Other	3	6
532	HEP.periportal_metabolic.stress_checkpoint	9.26e-03	Nonsignificant	0.95	0.84	Other	234	786
533	MAC.resident_cardiac.inflammatory_reparative	9.03e-03	Nonsignificant	0.13	1.35	Other	31	96
534	MAC.LAM.anti_inflammatory	9.00e-03	Nonsignificant	0.03	1.28	Other	86	132
535	MESO.baseline	8.74e-03	Nonsignificant	0.79	0.70	Other	0	6
536	B.age_associated.migratory	8.52e-03	Nonsignificant	0.27	1.24	Other	2	2
537	FIB.skin_neurosecretory.baseline	8.45e-03	Nonsignificant	—	0.00	Other	0	0
538	ASTRO.immature_lipid	8.43e-03	Nonsignificant	1.00	1.07	Other	23	113
539	MG.baseline	8.37e-03	Nonsignificant	0.15	1.29	Other	16	5
540	MAC.resident_repair.chemokine_angiocrine	8.09e-03	Nonsignificant	0.30	1.23	Other	87	138
541	ASPC.stem_like_progenitor	7.44e-03	Nonsignificant	1.00	0.01	Other	300	842
542	THYMO.DP_early	7.40e-03	Nonsignificant	1.00	1.01	Other	326	313
543	MAC.microglia_like.phagocytic_redox	7.05e-03	Nonsignificant	—	0.00	Other	0	0
544	IPSC.neuroendocrine_primed	6.94e-03	Nonsignificant	—	0.99	Other	0	0
545	ASTRO.stress_acute	6.92e-03	Nonsignificant	1.00	0.96	Other	60	56
546	EC.liver_sinusoidal.inflammatory	6.58e-03	Nonsignificant	—	0.00	Other	223	154
547	GRNLSA.stress_metabolic	6.44e-03	Nonsignificant	—	0.05	Other	1	2
548	NEU.INH_VIP.enkephalinergic	6.29e-03	Nonsignificant	—	1.68	Other	0	0
549	DC.cDC2.adhesion_signaling	6.28e-03	Nonsignificant	0.89	1.10	Other	35	9
550	EC.liver_sinusoidal.secretory_lipoprotein	5.83e-03	Nonsignificant	0.88	0.68	Other	120	70
551	MAC.MDM.LAM_like	5.61e-03	Nonsignificant	0.94	0.78	Other	12	14
552	FIB.suburothelial.inflammatory_prostanoid	5.57e-03	Nonsignificant	—	0.00	Other	0	0
553	DC.cDC2.antiviral	5.56e-03	Nonsignificant	0.98	0.91	Other	100	37
554	MAC.resident_cardiac.phagocytic_homeostasis	5.40e-03	Nonsignificant	0.70	0.92	Other	564	1,221
555	B.memory.pDC_imprint	5.30e-03	Nonsignificant	1.00	0.85	Other	157	103
556	MONO.CD14.cord_tolerance	5.14e-03	Nonsignificant	0.90	1.03	Other	864	753
557	MG.phagocytic_APC	4.97e-03	Nonsignificant	0.80	0.85	Other	25	8
558	FIB.skin_sheath.stress_chaperone	4.95e-03	Nonsignificant	—	0.00	Other	0	0
559	THYMO.proliferative_G2M	4.78e-03	Nonsignificant	—	0.42	Other	164	413
560	MESO.activated_migratory	4.76e-03	Nonsignificant	—	0.00	Other	0	0
561	T.CD4_naive.activated_stress	4.75e-03	Nonsignificant	1.00	5.21e-03	Other	339	429
562	MEL.dedifferentiated_migratory	4.57e-03	Nonsignificant	—	0.15	Other	0	0
563	IPSC.stromal_primed	4.08e-03	Nonsignificant	1.00	0.91	Other	0	0
564	NEU.INH_VIP.LAMP5_hybrid	3.81e-03	Nonsignificant	—	1.51	Other	1	9
565	GRNLSA.lipid_hypoxia	3.77e-03	Nonsignificant	1.00	0.61	Other	28	0
566	IPSC.canonical_pluripotent	3.65e-03	Nonsignificant	1.00	0.87	Other	0	0
567	MAC.MDM.complement_resolving	3.62e-03	Nonsignificant	0.94	0.73	Other	440	860
568	MAC.resident_repair.lipid_phagocytic	3.50e-03	Nonsignificant	0.67	1.24	Other	228	604
569	FIB.suburothelial.contractile_myofibroblast	3.43e-03	Nonsignificant	—	0.00	Other	9	0
570	T.CD8_Tcm.NK_like	3.43e-03	Nonsignificant	1.00	0.06	Other	334	581
571	MG.expanding	3.40e-03	Nonsignificant	0.80	0.78	Other	2	1
572	MESO.activated_stress	3.40e-03	Nonsignificant	—	0.00	Other	0	0
573	MEL.stress_glucocorticoid	3.23e-03	Nonsignificant	0.79	1.10	Other	11	34
574	HEP.periportal_metabolic.inflammatory_activated	3.20e-03	Nonsignificant	0.95	0.99	Other	712	1,610
575	MAC.resident_cardiac.antigen_presenting	3.06e-03	Nonsignificant	0.70	0.98	Other	52	27
576	MAC.resident_iron.heme_recycling	3.02e-03	Nonsignificant	—	0.00	Other	30	37
577	EPI.bile_duct_cholangiocyte.secretory_mucin	3.01e-03	Nonsignificant	—	0.00	Other	7	12
578	MAC.LAM.antimicrobial	2.94e-03	Nonsignificant	0.99	0.65	Other	389	93
579	MAC.kupffer.inflammatory	2.85e-03	Nonsignificant	—	0.00	Other	7	4
580	SCHWN.axon_contact_cardiac	2.60e-03	Nonsignificant	0.98	0.28	Other	18	63
581	FIB.skin_tenogenic.baseline	2.52e-03	Nonsignificant	—	0.00	Other	0	2
582	HEP.canalicular_transport.sterol_lipid_biosynthesis	2.32e-03	Nonsignificant	—	0.00	Other	10	20
583	DC.cDC2.migratory	2.14e-03	Nonsignificant	0.98	0.87	Other	185	39
584	IPSC.stress	2.02e-03	Nonsignificant	0.74	1.12	Other	0	0
585	EPI.hepatic_ductular_cholangiocyte.ion_transport	2.01e-03	Nonsignificant	—	0.40	Other	0	0
586	FIB.suburothelial.homeostasis_matrix	2.00e-03	Nonsignificant	1.00	0.00	Other	258	921
587	ASTRO.neuromodulatory	1.91e-03	Nonsignificant	1.00	0.91	Other	34	172
588	B.germinal_center.DZ_S_phase	1.88e-03	Nonsignificant	—	0.40	Other	0	0
589	HEP.acute_phase.baseline	1.86e-03	Nonsignificant	0.84	1.06	Other	946	19
590	MAC.LAM.lipid_phagocytosis	1.84e-03	Nonsignificant	0.93	0.88	Other	369	328
591	NEU.EXC_IT.guidance	1.73e-03	Nonsignificant	0.98	1.02	Other	274	63
592	FIB.adventitial.activated_remodelling	1.59e-03	Nonsignificant	—	0.00	Other	141	319
593	EPI.pancreatic_ductal_bicarbonate.baseline	1.58e-03	Nonsignificant	0.98	0.75	Other	11	42
594	THYMO.DP_early_stress	1.54e-03	Nonsignificant	—	0.55	Other	0	0
595	FIB.skin_sheath.ECM_immune	1.47e-03	Nonsignificant	—	0.00	Other	0	0
596	OPC.homeostatic	1.34e-03	Nonsignificant	0.10	1.29	Other	394	160
597	MEL.secretory_quiescent	1.29e-03	Nonsignificant	0.90	0.79	Other	19	13
598	THYMO.SP_CD8_transitional	1.24e-03	Nonsignificant	1.00	0.80	Other	32	75
599	NEU.INH_VIP.develop_niche	1.22e-03	Nonsignificant	—	1.08	Other	0	0
600	FIB.barrier_secretory.remodeling	1.13e-03	Nonsignificant	—	0.00	Other	0	0
601	IPSC.endoderm_primed	1.13e-03	Nonsignificant	1.00	0.83	Other	0	0
602	EC.liver_sinusoidal.remodeling_lipotoxicity	1.07e-03	Nonsignificant	—	0.00	Other	90	58
603	FIB.skin_papillary.baseline	1.07e-03	Nonsignificant	—	0.00	Other	0	0
604	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.06e-03	Nonsignificant	—	0.00	Other	0	0
605	ASTRO.stress_mito	1.01e-03	Nonsignificant	1.00	0.97	Other	47	110
606	B.germinal_center.LZ_selection	9.25e-04	Nonsignificant	—	0.00	Other	0	0
607	DC.cDC2.monocyte_like	9.19e-04	Nonsignificant	0.98	0.71	Other	1,285	791
608	HEP.periportal_metabolic.apolipoprotein_secretory	9.05e-04	Nonsignificant	0.95	0.84	Other	43	110
609	B.age_associated.activated	8.99e-04	Nonsignificant	—	0.00	Other	18	22
610	MAC.resident_repair.antigen_presenting	8.47e-04	Nonsignificant	0.84	0.81	Other	244	113
611	NEU.INH_VIP.regulatory_remodeling	6.56e-04	Nonsignificant	—	0.28	Other	6	1
612	MAC.resident_repair.ECM_stromal_crosstalk	6.49e-04	Nonsignificant	0.84	0.76	Other	95	158
613	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	6.10e-04	Nonsignificant	—	0.00	Other	0	0
614	THYMO.SP_CD4_naive	5.88e-04	Nonsignificant	1.00	0.84	Other	65	75
615	MEL.mature_oxidative_traffic	5.37e-04	Nonsignificant	0.79	0.99	Other	247	285
616	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	5.01e-04	Nonsignificant	—	0.00	Other	5	3
617	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	4.83e-04	Nonsignificant	0.98	0.94	Other	40	191
618	MAC.resident_repair.stress_iron	4.70e-04	Nonsignificant	0.84	0.87	Other	48	97
619	MONO.CD14.inflammatory	4.48e-04	Nonsignificant	1.00	0.81	Other	92	134
620	GRNLSA.cholesterol_mevalonate	3.71e-04	Nonsignificant	1.00	0.39	Other	9	4
621	EPI.hepatic_ductular_cholangiocyte.secretory_transport	3.65e-04	Nonsignificant	—	0.00	Other	0	0
622	EPI.pancreatic_ductal_bicarbonate.inflammatory	3.64e-04	Nonsignificant	0.98	0.85	Other	14	32
623	GRNLSA.EMT_insulin_signaling	3.57e-04	Nonsignificant	1.00	0.31	Other	47	84
624	OPC.premyelinating	3.54e-04	Nonsignificant	0.92	0.69	Other	185	12
625	OPC.proliferative_immune_interact	3.43e-04	Nonsignificant	0.92	0.76	Other	180	373
626	B.age_associated.naive_transitional	3.34e-04	Nonsignificant	—	0.00	Other	0	0
627	MONO.CD14.repair_M2_like	3.21e-04	Nonsignificant	1.00	0.56	Other	550	1,495
628	THYMO.CD8aa_IELp	3.17e-04	Nonsignificant	—	0.00	Other	1	7
629	THYMO.SP_CD8_naive	2.71e-04	Nonsignificant	1.00	0.42	Other	297	177
630	NEU.INH_LAMP5.exc_inh_balance	2.66e-04	Nonsignificant	—	0.00	Other	46	2
631	NEU.EXC_IT.neuromodulated	2.66e-04	Nonsignificant	0.98	0.75	Other	176	116
632	NEU.INH_VIP.excitatory_coupled	1.99e-04	Nonsignificant	—	0.08	Other	13	0
633	NEU.EXC_IT.callosal	1.94e-04	Nonsignificant	0.98	0.90	Other	286	119
634	MONO.CD16.hepatic_mac_like	1.91e-04	Nonsignificant	0.58	1.10	Other	803	117
635	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.78e-04	Nonsignificant	—	0.00	Other	49	237
636	NEU.INH_VIP.matrix	1.73e-04	Nonsignificant	—	0.09	Other	24	77
637	NEU.INH_VIP.nuclear_reg	1.71e-04	Nonsignificant	—	0.10	Other	20	4
638	HPC.MEP	1.63e-04	Nonsignificant	1.00	0.00	Other	599	1,195
639	MAC.kupffer.metabolic	1.60e-04	Nonsignificant	—	0.00	Other	25	36
640	NEU.EXC_IT.transitional	1.49e-04	Nonsignificant	0.98	0.82	Other	237	142
641	IPSC.mesenchymal_primed	1.45e-04	Nonsignificant	1.00	0.55	Other	0	0
642	ASPC.signal_integrator	1.29e-04	Nonsignificant	—	0.00	Other	0	0
643	HEP.acute_phase.hypoxia_lipid	1.27e-04	Nonsignificant	—	1.37	Other	0	0
644	MONO.CD14.APC_like	1.25e-04	Nonsignificant	1.00	0.56	Other	1,686	2,493
645	ASTRO.A2_reactive	1.24e-04	Nonsignificant	1.00	0.76	Other	10	37
646	ASTRO.A1_reactive	1.18e-04	Nonsignificant	1.00	0.66	Other	433	394
647	NEU.INH_VIP.cannabinoid	1.15e-04	Nonsignificant	—	0.08	Other	0	0
648	GRNLSA.p53_damage	1.05e-04	Nonsignificant	—	0.00	Other	13	10
649	GRANU.neutrophil.primed_degranulation	9.97e-05	Nonsignificant	—	0.64	Other	0	0
650	EC.liver_sinusoidal.stress	9.71e-05	Nonsignificant	—	0.00	Other	413	158
651	HEP.acute_phase.complement_metabolic	9.63e-05	Nonsignificant	0.88	1.00	Other	1,423	3,464
652	MAC.kupffer.fibrogenic	8.81e-05	Nonsignificant	—	0.00	Other	0	0
653	EPI.pancreatic_ductal_bicarbonate.activated	8.06e-05	Nonsignificant	0.98	0.42	Other	10	7
654	NEU.INH_LAMP5.projecting	7.92e-05	Nonsignificant	—	0.26	Other	0	0
655	NEU.INH_VIP.canonical_disinhibitory	6.90e-05	Nonsignificant	0.61	0.95	Other	59	38
656	NEU.EXC_IT.adhesion	6.80e-05	Nonsignificant	0.98	0.62	Other	252	108
657	NEU.INH_LAMP5.glial_interface	6.67e-05	Nonsignificant	—	0.27	Other	0	0
658	MAC.kupffer.monocyte_like	6.52e-05	Nonsignificant	—	0.00	Other	0	0
659	IPSC.neural_primed	4.23e-05	Nonsignificant	1.00	0.44	Other	0	0
660	MONO.CD16.patrolling	3.77e-05	Nonsignificant	1.00	0.92	Other	797	216
661	NEU.INH_VIP.serotonergic	3.56e-05	Nonsignificant	—	0.00	Other	9	2
662	NEU.INH_LAMP5.rosehip	3.33e-05	Nonsignificant	—	0.00	Other	0	0
663	NEU.INH_VIP.opioid	2.85e-05	Nonsignificant	—	0.00	Other	50	9
664	IPSC.midbrain_primed	2.55e-05	Nonsignificant	1.00	0.56	Other	0	0
665	NEU.EXC_CT.remodeling	2.54e-05	Nonsignificant	—	0.47	Other	23	1
666	B.germinal_center.LZ_survival	2.37e-05	Nonsignificant	—	0.00	Other	0	0
667	B.germinal_center.LZ_memory_precursor	2.22e-05	Nonsignificant	—	0.00	Other	0	0
668	EPI.hepatic_ductular_cholangiocyte.polarity	2.10e-05	Nonsignificant	—	0.00	Other	0	0
669	HEP.acute_phase.stress_secretory	1.87e-05	Nonsignificant	0.88	1.10	Other	26	3
670	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.79e-05	Nonsignificant	—	0.00	Other	0	0
671	MONO.CD16.baseline	1.69e-05	Nonsignificant	1.00	0.96	Other	50	1
672	ASTRO.homeostatic	1.52e-05	Nonsignificant	1.00	0.53	Other	200	431
673	GRANU.neutrophil.antiviral_endotoxin	1.01e-05	Nonsignificant	—	0.00	Other	0	0
674	HEP.acute_phase.complement_antiviral	7.34e-06	Nonsignificant	0.88	0.85	Other	377	751
675	DC.pDC.immature_metabolic	6.52e-06	Nonsignificant	0.41	1.18	Other	78	124
676	HEP.acute_phase.inflammatory	6.31e-06	Nonsignificant	0.88	0.83	Other	382	649
677	NEU.EXC_SYT2.synaptic	6.21e-06	Nonsignificant	—	0.00	Other	0	0
678	NEU.EXC_NTNG1.nuclear_reg	5.82e-06	Nonsignificant	—	0.67	Other	0	0
679	NEU.EXC_CT.projector	4.43e-06	Nonsignificant	0.61	0.95	Other	87	26
680	DC.pDC.poised_migratory	4.28e-06	Nonsignificant	0.72	0.90	Other	54	95
681	DC.pDC.baseline	4.26e-06	Nonsignificant	0.41	1.25	Other	88	123
682	NEU.EXC_CT.Ca2_signaling	1.59e-06	Nonsignificant	—	0.00	Other	68	17
683	MONO.CD16.inflammatory	1.07e-06	Nonsignificant	1.00	0.57	Other	1,640	168
684	NEU.EXC_SYT2.nuclear_reg	3.02e-07	Nonsignificant	—	0.00	Other	0	0
685	HEP.acute_phase.proliferative	2.80e-07	Nonsignificant	—	0.00	Other	4	6
686	GRANU.neutrophil.tissue_patrolling	2.21e-07	Nonsignificant	—	0.00	Other	0	0
687	NEU.EXC_NTNG1.synaptic	1.26e-07	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_CT.Ca2_sensor	1.07e-08	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

20 unique genes. Showing 1–20. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ENSG00000291209	02-Medium	0.61	10.48	G1	C2	—	—	—	18	102
ENSG00000262879	02-Medium	0.60	11.84	G2	C2	—	—	—	3	2
RPRML	02-Medium	0.57	9.26	G1	C2	—	EC.capillary (Tier: specific)	17 cells — complete matches	28	120
GOSR2	02-Medium	0.52	8.17	G1	C2	—	—	EC.arterial.ion_pump (L2)	27	119
GOSR2-DT	02-Medium	0.49	7.14	G1	C2	—	—	—	27	119
ENSG00000262633	02-Medium	0.48	6.76	G1	C2	—	—	—	27	119
LRRC37A2	02-Medium	0.45	8.97	G2	C2	—	—	21 cells — complete matches	23	78
CDC27	02-Medium	0.44	11.24	G2	C2	—	—	EC.arterial.mito_contact (L2)	9	23
LINC01708	02-Medium	0.41	5.01	G2	C1	—	EC.arterial (Tier: specific)	6 cells — complete matches	2	4
ENSG00000262265	02-Medium	0.38	8.86	G2	C2	—	—	—	6	15
NSF	02-Medium	0.36	7.10	G2	C2	—	—	10 cells — complete matches	18	54
WNT9B	02-Medium	0.33	4.40	G2	C2	EC.heart_remodeling.remodeling_secretory (L2)	EC.capillary.angiocrine (Tier: specific)	9 cells — complete matches	32	131
ENSG00000294414	02-Medium	0.31	8.49	G2	C2	—	—	—	0	0
MYL4	02-Medium	0.24	8.20	G2	C2	FIB.skin_tenogenic.baseline (L2)	—	19 cells — complete matches	9	23
ITGB3	02-Medium	0.17	5.74	G2	C2	EC.liver_sinusoidal.inflammatory (L2), MONO.CD14.platelet_bound (L2), MONO.CD16.platelet_bound (L2)	EC.venous.baseline (Tier: specific) EC.capillary.inflammatory (Tier: relevant) EC.venous.activated (Tier: relevant) EPI.lung_club_secretory.inflammatory (Tier: relevant) EPI.salivary_myoepithelial.contractile_repair (Tier: relevant)	48 cells — complete matches	15	38
ENSG00000259753	02-Medium	0.17	5.74	G2	C2	—	—	—	15	38
ENSG00000302539	02-Medium	0.17	5.68	G2	C2	—	—	—	15	38
ENSG00000304881	02-Medium	0.13	4.32	G2	C2	—	—	—	9	23
EFCAB13	02-Medium	0.12	3.55	G2	C2	—	—	27 cells — complete matches	87	307
EFCAB13-DT	02-Medium	0.12	3.85	G2	C2	—	—	—	92	336

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.