Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000099 · All tissues

Any dementia (more control exclusions): evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Dementia

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	monocyte	48.26	Significant	3.30e-49	1.26	Specific	2,176	3,871
2	macrophage	14.94	Significant	5.46e-08	1.10	Specific	813	1,732
3	platelet	14.48	Significant	—	1.22	Relevant	85	104
4	dendritic_cell	12.38	Significant	1.00	1.03	Relevant	496	724
5	granulocyte	5.27	Nominal	1.00	1.09	Other	5	6
6	microglia	4.87	Nominal	1.00	0.92	Other	61	129
7	induced_pluripotent_stem_cell	2.44	Nonsignificant	1.00	0.92	Other	0	0
8	endothelial_cell	2.42	Nonsignificant	1.00	0.89	Other	373	974
9	granulosa_cell	2.37	Nonsignificant	1.00	0.86	Other	293	670
10	hepatocyte	2.34	Nonsignificant	1.00	0.83	Other	1,515	3,822
11	B_cell	2.23	Nonsignificant	1.00	0.87	Other	356	694
12	epithelial_cell	1.44	Nonsignificant	1.00	0.85	Other	24	47
13	oligodendrocyte_precursor_cell	0.76	Nonsignificant	1.00	0.80	Other	461	1,454
14	neuron	0.64	Nonsignificant	1.00	0.72	Other	330	1,328
15	astrocyte	0.52	Nonsignificant	1.00	0.71	Other	256	1,203
16	muscle_stem_cell	0.30	Nonsignificant	1.00	0.70	Other	7	27
17	smooth_muscle_cell	0.29	Nonsignificant	1.00	0.73	Other	27	139
18	oligodendrocyte	0.18	Nonsignificant	1.00	0.67	Other	385	1,507
19	pericyte	0.15	Nonsignificant	1.00	0.69	Other	128	517
20	plasma_cell	0.15	Nonsignificant	1.00	0.66	Other	17	24
21	mesothelial_cell	0.14	Nonsignificant	1.00	0.63	Other	6	36
22	haematopoietic_progenitor_cell	0.12	Nonsignificant	1.00	0.63	Other	262	502
23	schwann_cell	0.12	Nonsignificant	1.00	0.69	Other	10	57
24	skeletal_muscle_cell	0.09	Nonsignificant	1.00	0.63	Other	944	2,600
25	fibroblast	0.08	Nonsignificant	1.00	0.63	Other	184	826
26	adipose_stem_and_progenitor_cell	0.06	Nonsignificant	1.00	0.61	Other	327	954
27	chondrocyte	4.56e-03	Nonsignificant	1.00	0.52	Other	548	1,069
28	innate_lymphoid_cell_2	3.19e-03	Nonsignificant	1.00	0.52	Other	3	8
29	melanocyte	2.55e-03	Nonsignificant	1.00	0.49	Other	97	309
30	thymocyte	2.45e-03	Nonsignificant	1.00	0.50	Other	168	512
31	cardiomyocyte	1.68e-03	Nonsignificant	1.00	0.56	Other	533	2,045
32	T_cell	1.40e-03	Nonsignificant	1.00	0.34	Other	470	959
33	natural_killer_cell	1.33e-03	Nonsignificant	1.00	0.53	Other	1,204	2,052
34	adipocyte	1.43e-06	Nonsignificant	1.00	0.28	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MONO.CD14	53.44	Significant	2.00e-50	3.71	Specific	2,294	4,139
2	MAC.alveolar	43.51	Significant	1.80e-30	2.83	Specific	1,432	3,122
3	MONO.CD16	21.31	Significant	1.00	0.09	Specific	1,304	1,835
4	MAC.MDM	17.59	Significant	0.02	1.53	Specific	623	986
5	DC.cDC2	15.99	Significant	2.24e-19	2.27	Specific	1,189	1,793
6	MAC.proliferating	15.55	Significant	0.58	1.23	Relevant	87	253
7	MAC.LAM	14.78	Significant	0.09	1.29	Specific	914	2,064
8	PLAT.platelet	14.48	Significant	—	0.00	Relevant	38	53
9	GRANU.neutrophil	14.23	Significant	9.43e-04	1.36	Specific	1,235	2,649
10	MAC.resident_repair	13.52	Significant	0.88	1.01	Relevant	796	1,426
11	MAC.resident_iron	8.55	Significant	1.00	0.13	Relevant	16	21
12	EPI.renal_proximal_tubule	7.99	Significant	6.21e-09	1.80	Specific	525	806
13	MAC.microglia_like	6.98	Significant	1.00	0.23	Relevant	124	179
14	MAC.resident_cardiac	5.90	Significant	1.00	0.08	Relevant	485	1,074
15	EC.liver_sinusoidal	5.78	Significant	4.19e-05	1.68	Other	1,083	1,925
16	HEP.periportal_metabolic	5.34	Nominal	3.00e-50	1.82	Other	1,750	4,427
17	EPI.cervical_suprabasal	5.02	Nominal	—	1.41	Other	14	50
18	MG.microglia	4.87	Nominal	—	—	Other	49	0
19	EPI.renal_principal_cell	4.72	Nominal	4.46e-05	1.56	Other	207	403
20	EPI.renal_distal_tubule	4.72	Nominal	0.09	1.39	Other	133	361
21	EPI.renal_immature_ureteric_bud	4.67	Nominal	3.25e-06	1.63	Other	217	569
22	EPI.renal_intercalated_cell_type_B	4.64	Nominal	—	1.52	Other	6	7
23	MAC.kupffer	4.35	Nominal	1.00	0.01	Other	189	530
24	EPI.ectocervical_granular	3.73	Nominal	—	1.32	Other	11	23
25	EPI.endocervical_secretory	3.53	Nominal	—	1.30	Other	0	0
26	B.age_associated	3.50	Nominal	0.49	1.14	Other	207	350
27	EPI.renal_intercalated_cell_type_A	3.47	Nominal	0.24	1.24	Other	67	142
28	EC.venous	3.33	Nominal	4.11e-09	1.50	Other	516	1,387
29	B.memory	3.31	Nominal	3.75e-19	1.77	Other	442	882
30	EC.capillary	3.23	Nominal	2.19e-03	1.26	Other	514	1,635
31	EPI.renal_thick_ascending_limb	2.86	Nonsignificant	2.29e-04	1.35	Other	453	1,153
32	EPI.salivary_mucous_acinar	2.83	Nonsignificant	0.01	1.33	Other	639	1,189
33	EPI.alveolar_type_2	2.52	Nonsignificant	0.06	1.22	Other	813	1,853
34	DC.pDC	2.48	Nonsignificant	1.00	0.06	Other	496	1,028
35	IPSC.induced_pluripotent_stem_cell	2.44	Nonsignificant	—	—	Other	0	0
36	NEU.EXC_CT	2.38	Nonsignificant	0.09	1.23	Other	362	384
37	GRNLSA.granulosa_cell	2.37	Nonsignificant	—	—	Other	257	0
38	DC.cDC1	2.09	Nonsignificant	1.00	0.23	Other	55	112
39	EPI.ileal_goblet	2.06	Nonsignificant	0.24	1.25	Other	181	432
40	HEP.pericentral_lipoprotein	1.98	Nonsignificant	—	0.47	Other	0	0
41	EPI.pancreatic_ductal_perivascular	1.90	Nonsignificant	1.00	0.96	Other	4	30
42	EPI.esophageal_suprabasal	1.84	Nonsignificant	1.00	1.01	Other	158	404
43	EPI.pancreatic_ductal_progenitor	1.74	Nonsignificant	1.00	1.08	Other	234	873
44	EC.lymphatic	1.68	Nonsignificant	1.00	0.74	Other	630	998
45	EPI.skin_keratinocyte_progenitor	1.53	Nonsignificant	—	0.39	Other	0	3
46	EPI.colonocyte	1.53	Nonsignificant	1.00	0.90	Other	294	815
47	DC.mig	1.46	Nonsignificant	—	0.00	Other	89	156
48	EPI.skin_hair_follicle_bulge	1.39	Nonsignificant	1.00	0.98	Other	51	178
49	B.naive	1.36	Nonsignificant	1.00	0.41	Other	307	595
50	EPI.skin_sebaceous_duct_luminal	1.33	Nonsignificant	1.00	0.94	Other	100	249
51	EPI.tracheal_suprabasal	1.30	Nonsignificant	1.00	0.85	Other	29	56
52	EPI.gastric_foveolar	1.27	Nonsignificant	—	0.26	Other	0	0
53	EPI.tracheal_basal	1.23	Nonsignificant	1.00	0.87	Other	398	1,120
54	EPI.skin_interfollicular_spinous	1.15	Nonsignificant	1.00	0.91	Other	260	563
55	EPI.skin_follicular_keratinizing	1.14	Nonsignificant	1.00	0.84	Other	30	81
56	EPI.esophageal_basal	1.08	Nonsignificant	1.00	0.84	Other	4	10
57	NEU.EXC_SYT2	1.02	Nonsignificant	—	0.96	Other	40	77
58	HEP.acute_phase	1.01	Nonsignificant	1.00	0.81	Other	1,441	3,641
59	EC.arterial	1.00	Nonsignificant	1.00	0.39	Other	356	885
60	EPI.colonic_tuft	0.93	Nonsignificant	—	8.80e-03	Other	7	24
61	EPI.pancreatic_islet	0.88	Nonsignificant	3.30e-05	1.72	Other	52	132
62	EPI.skin_keratinocyte_basal	0.87	Nonsignificant	—	0.00	Other	13	26
63	EPI.intrahepatic_cholangiocyte_transport	0.87	Nonsignificant	—	0.05	Other	12	42
64	EPI.lung_club_secretory	0.85	Nonsignificant	1.00	0.62	Other	5	14
65	EPI.ileal_enterocyte_absorptive	0.85	Nonsignificant	1.00	0.80	Other	118	338
66	EPI.skin_keratinocyte_proliferating	0.83	Nonsignificant	1.00	0.80	Other	47	76
67	EPI.ileal_enterocyte_crypt	0.82	Nonsignificant	1.00	0.71	Other	67	113
68	OPC.oligodendrocyte_precursor_cell	0.76	Nonsignificant	—	—	Other	413	1,269
69	FIB.neurolectin_mucosa	0.71	Nonsignificant	0.03	1.18	Other	133	394
70	NEU.EXC_IT	0.63	Nonsignificant	0.08	1.15	Other	411	192
71	EPI.pancreatic_ductal_bicarbonate	0.53	Nonsignificant	1.00	0.57	Other	131	548
72	ASTRO.astrocyte	0.52	Nonsignificant	—	—	Other	228	1,111
73	EPI.bile_duct_cholangiocyte	0.47	Nonsignificant	1.00	0.59	Other	37	60
74	EPI.hepatic_ductular_cholangiocyte	0.46	Nonsignificant	1.00	0.56	Other	83	243
75	FIB.suburothelial	0.44	Nonsignificant	0.03	1.18	Other	122	432
76	EPI.ileal_bile_transport	0.44	Nonsignificant	1.00	0.66	Other	61	93
77	EPI.skin_appendage_keratinocyte	0.38	Nonsignificant	1.00	0.64	Other	87	222
78	EPI.thymic_medullary	0.30	Nonsignificant	1.00	0.56	Other	26	133
79	MUSC.muscle_stem_cell	0.30	Nonsignificant	—	—	Other	4	18
80	EPI.colonic_enteroendocrine	0.29	Nonsignificant	—	0.00	Other	1	1
81	SMC.smooth_muscle_cell	0.29	Nonsignificant	—	—	Other	20	101
82	EPI.extrahepatic_cholangiocyte	0.29	Nonsignificant	—	0.00	Other	37	71
83	EPI.skin_hair_follicle_companion	0.27	Nonsignificant	—	0.00	Other	8	12
84	EPI.tracheal_submucosal_gland	0.26	Nonsignificant	—	0.00	Other	0	0
85	EPI.salivary_intercalated_defense	0.26	Nonsignificant	1.00	0.54	Other	81	161
86	HEP.canalicular_transport	0.26	Nonsignificant	1.00	0.00	Other	1,290	3,434
87	EPI.skin_sweat_duct_keratinocyte	0.25	Nonsignificant	1.00	0.53	Other	146	301
88	FIB.barrier_secretory	0.24	Nonsignificant	0.03	1.27	Other	81	228
89	FIB.barrier_purinergic	0.24	Nonsignificant	—	1.26	Other	1	3
90	EPI.intrahepatic_cholangiocyte_defense	0.22	Nonsignificant	—	0.00	Other	8	13
91	FIB.lung_alveolar	0.20	Nonsignificant	—	1.14	Other	6	15
92	SKM.type_1_slow	0.19	Nonsignificant	3.26e-23	1.72	Other	923	2,478
93	FIB.perivascular_interface	0.19	Nonsignificant	1.00	1.02	Other	0	0
94	OLG.oligodendrocyte	0.18	Nonsignificant	—	—	Other	384	1,397
95	FIB.tracheal_subepithelial	0.16	Nonsignificant	—	1.12	Other	0	0
96	PC.IgA_muocsal	0.16	Nonsignificant	0.01	1.52	Other	18	31
97	PERI.pericyte	0.15	Nonsignificant	—	—	Other	117	0
98	NEU.INH_PVALB	0.14	Nonsignificant	1.00	0.68	Other	193	183
99	MESO.mesothelial_cell	0.14	Nonsignificant	—	—	Other	2	18
100	GRANU.MAST	0.13	Nonsignificant	1.00	0.00	Other	5	6
101	NEU.INH_VIP	0.12	Nonsignificant	1.00	0.58	Other	241	366
102	HPC.haematopoietic_progenitor_cell	0.12	Nonsignificant	—	—	Other	211	370
103	SCHWN.schwann_cell	0.12	Nonsignificant	—	—	Other	7	33
104	FIB.skin_neurosecretory	0.12	Nonsignificant	—	0.97	Other	0	0
105	PC.IgG_systemic	0.07	Nonsignificant	0.99	0.51	Other	41	60
106	EPI.salivary_duct_ion_transport	0.06	Nonsignificant	1.00	0.42	Other	5	11
107	ASPC.adipose_stem_and_progenitor_cell	0.06	Nonsignificant	—	—	Other	324	930
108	EPI.thymic_cortical	0.06	Nonsignificant	1.00	0.47	Other	442	824
109	EPI.lung_multiciliated	0.05	Nonsignificant	1.00	0.42	Other	16	49
110	FIB.reticular	0.05	Nonsignificant	1.00	0.88	Other	19	87
111	NEU.EXC_NTNG1	0.04	Nonsignificant	—	0.00	Other	0	0
112	FIB.interstitial	0.04	Nonsignificant	1.00	0.92	Other	288	940
113	EC.heart_remodeling	0.03	Nonsignificant	1.00	0.00	Other	569	1,594
114	NEU.INH_LAMP5	0.03	Nonsignificant	1.00	0.28	Other	263	532
115	FIB.skin_sheath	0.02	Nonsignificant	1.00	0.98	Other	49	118
116	FIB.adventitial	0.02	Nonsignificant	1.00	0.86	Other	268	1,447
117	SKM.type_2_fast	0.02	Nonsignificant	1.00	0.67	Other	972	2,639
118	EPI.pancreatic_ductal_mucinous	0.02	Nonsignificant	1.00	0.40	Other	219	430
119	FIB.hepatic_stellate_cell	0.01	Nonsignificant	—	0.47	Other	64	252
120	T.CD8_Tcm	0.01	Nonsignificant	7.11e-03	1.09	Other	460	926
121	FIB.skin_tenogenic	9.40e-03	Nonsignificant	—	0.44	Other	108	227
122	EPI.salivary_serous_acinar	7.34e-03	Nonsignificant	1.00	0.29	Other	233	531
123	EPI.salivary_duct_excretory	5.94e-03	Nonsignificant	1.00	0.34	Other	85	180
124	T.CD4_Trm	5.58e-03	Nonsignificant	0.69	1.02	Other	176	363
125	T.CD4_Tfh	5.49e-03	Nonsignificant	0.69	1.04	Other	47	45
126	EPI.alveolar_type_1	5.25e-03	Nonsignificant	1.00	0.38	Other	26	101
127	CHOND.chondrocyte	4.56e-03	Nonsignificant	—	—	Other	519	730
128	T.CD4_Th2	4.14e-03	Nonsignificant	—	1.73	Other	1	2
129	T.CD4_transitional	3.64e-03	Nonsignificant	0.69	1.02	Other	48	110
130	ILC2.innate_lymphoid_cell_2	3.19e-03	Nonsignificant	—	—	Other	2	0
131	MEL.melanocyte	2.55e-03	Nonsignificant	—	—	Other	79	242
132	THYMO.thymocyte	2.45e-03	Nonsignificant	—	—	Other	163	495
133	T.CD4_Th17	2.13e-03	Nonsignificant	0.69	1.05	Other	421	794
134	FIB.skin_papillary	2.10e-03	Nonsignificant	—	0.20	Other	0	0
135	CM.cardiomyocyte	1.68e-03	Nonsignificant	—	—	Other	524	2,032
136	T.CD8_Trm	1.47e-03	Nonsignificant	0.99	0.99	Other	211	346
137	NK.natural_killer_cell	1.33e-03	Nonsignificant	—	—	Other	1,204	2,045
138	FIB.transitioning	1.10e-03	Nonsignificant	1.00	0.57	Other	172	497
139	T.CD4_Tcm	9.66e-04	Nonsignificant	0.69	1.02	Other	494	988
140	T.CD8_transitional	9.58e-04	Nonsignificant	0.69	1.02	Other	497	932
141	T.CD4_naive	8.74e-04	Nonsignificant	0.99	0.99	Other	399	866
142	T.CD4_Tem	8.04e-04	Nonsignificant	0.99	0.99	Other	365	697
143	EPI.salivary_myoepithelial	5.93e-04	Nonsignificant	1.00	0.29	Other	191	714
144	EPI.pancreatic_acinar	5.73e-04	Nonsignificant	1.00	0.25	Other	429	1,475
145	T.MAIT	5.46e-04	Nonsignificant	0.99	0.94	Other	469	855
146	T.CD8_Tem	2.82e-04	Nonsignificant	0.69	1.01	Other	1,083	1,857
147	T.CD8_naive	2.80e-04	Nonsignificant	0.99	0.97	Other	317	708
148	T.gamma_delta	1.23e-04	Nonsignificant	0.99	0.97	Other	588	1,078
149	T.CD4_Treg	7.26e-05	Nonsignificant	0.99	0.86	Other	244	511
150	B.germinal_center	2.18e-05	Nonsignificant	1.00	7.14e-03	Other	233	655
151	T.CD4_cytotoxic	6.19e-06	Nonsignificant	0.99	0.89	Other	855	1,493
152	ADIPO.adipocyte	1.43e-06	Nonsignificant	—	—	Other	20	62

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MONO.CD14.remodeling	66.23	Significant	1.60e-14	2.56	—	2,373	295
2	MONO.CD14.platelet_bound	60.93	Significant	0.15	1.56	—	964	176
3	MAC.alveolar.scavenging_endocytic	56.47	Significant	—	0.93	Relevant	140	283
4	MAC.alveolar.biosynthetic_sterol_heme	53.67	Significant	0.25	1.71	—	347	40
5	MONO.CD14.baseline	53.61	Significant	1.00	0.97	—	2,268	76
6	MONO.CD14.APC_like	48.75	Significant	1.00	0.60	Specific	1,686	2,493
7	MAC.alveolar.capillary_interacting	42.04	Significant	0.69	1.18	Relevant	113	181
8	MAC.alveolar.inflammatory	40.83	Significant	0.88	0.80	Relevant	208	312
9	MAC.alveolar.stress_metabolic	36.14	Significant	0.96	0.25	Relevant	116	148
10	MAC.alveolar.lipid_autophagy	34.97	Significant	—	0.00	Relevant	35	44
11	MONO.CD16.platelet_bound	30.53	Significant	0.13	1.60	Relevant	372	508
12	MONO.CD16.inflammatory	29.93	Significant	3.90e-09	2.54	—	1,640	168
13	DC.cDC2.monocyte_like	29.74	Significant	6.13e-03	1.86	—	1,285	791
14	PLAT.megakaryocytic	26.69	Significant	—	0.97	—	0	0
15	MONO.CD16.hepatic_mac_like	26.23	Significant	0.05	1.71	—	803	117
16	MAC.proliferating.stress	24.21	Significant	—	0.53	Relevant	87	136
17	MONO.CD14.repair_M2_like	22.09	Significant	1.00	0.09	Relevant	550	1,495
18	DC.cDC2.migratory	21.07	Significant	0.22	1.43	—	185	39
19	MAC.resident_repair.lipid_phagocytic	20.93	Significant	6.29e-04	2.49	Specific	228	604
20	MAC.MDM.inflammatory_phagocytic	20.57	Significant	8.81e-03	2.15	—	199	52
21	MONO.CD16.baseline	19.31	Significant	0.57	1.02	—	50	1
22	GRANU.neutrophil.tissue_patrolling	18.62	Significant	—	1.28	Relevant	0	0
23	MAC.MDM.complement_resolving	17.65	Significant	0.32	1.42	Relevant	440	860
24	MAC.MDM.LAM_like	17.06	Significant	0.76	0.89	Relevant	12	14
25	MAC.LAM.antimicrobial	17.03	Significant	0.24	1.50	—	389	93
26	MAC.LAM.inflammatory_APC	16.34	Significant	0.02	1.84	—	872	165
27	MONO.CD14.inflammatory	15.01	Significant	1.00	0.06	—	92	134
28	MAC.resident_repair.antigen_presenting	14.93	Significant	0.23	1.55	—	244	113
29	MAC.resident_repair.stress_iron	14.07	Significant	0.59	1.17	Relevant	48	97
30	MAC.MDM.APC_dendritic	13.97	Significant	0.98	0.18	—	48	15
31	DC.cDC2.proliferative	13.87	Significant	—	0.00	Relevant	39	71
32	DC.cDC2.adhesion_signaling	13.59	Significant	1.00	0.79	—	35	9
33	GRANU.neutrophil.antiviral_endotoxin	13.37	Significant	—	0.26	Relevant	0	0
34	MAC.LAM.perivascular_angiocrine	12.98	Significant	—	0.00	—	53	138
35	MONO.CD16.patrolling	12.95	Significant	1.00	0.08	—	797	216
36	DC.cDC2.tolerogenic_regulatory	12.39	Significant	1.00	0.48	—	44	4
37	MAC.resident_repair.ECM_stromal_crosstalk	12.07	Significant	0.97	0.32	Relevant	95	158
38	MAC.resident_repair.chemokine_angiocrine	11.92	Significant	0.97	0.28	Relevant	87	138
39	MAC.LAM.lipid_opsonization	11.82	Significant	1.00	0.32	—	45	14
40	MAC.proliferating.DNA_replication	11.46	Significant	0.91	0.46	Relevant	3	6
41	GRANU.neutrophil.primed_degranulation	11.39	Significant	—	0.00	—	0	0
42	DC.cDC2.antiviral	11.25	Significant	1.00	0.64	—	100	37
43	MAC.LAM.anti_inflammatory	11.24	Significant	1.00	0.03	Relevant	86	132
44	MAC.resident_iron.heme_recycling	10.82	Significant	—	0.42	—	30	37
45	MAC.resident_iron.heme_catabolism	10.65	Significant	0.42	1.22	—	30	51
46	MAC.LAM.lipid_phagocytosis	10.62	Significant	1.00	0.09	—	369	328
47	EC.liver_sinusoidal.stress	10.15	Significant	—	1.41	Specific	413	158
48	MAC.resident_iron.APC_iron_sensing	9.79	Significant	0.28	1.39	—	211	114
49	MAC.resident_cardiac.inflammatory_reparative	9.09	Significant	9.23e-04	2.34	Specific	31	96
50	EPI.ectocervical_granular.immune_interact	8.94	Significant	—	1.15	Relevant	0	0
51	IPSC.midbrain_primed	8.91	Significant	0.11	1.24	Relevant	0	0
52	EPI.pancreatic_islet.delta	8.91	Significant	—	1.64	Relevant	0	0
53	DC.cDC2.pro_inflammatory	8.64	Significant	1.00	0.09	—	3	5
54	EPI.renal_proximal_tubule.detox_antioxidant	8.33	Significant	0.07	2.10	—	394	77
55	IPSC.mesenchymal_primed	8.27	Significant	2.41e-07	1.30	Relevant	0	0
56	MAC.microglia_like.inflammatory_chemokine	7.82	Significant	—	0.32	Relevant	20	32
57	EPI.renal_proximal_tubule.onecarbon_peroxisome	7.53	Significant	1.00	0.00	Relevant	58	89
58	MAC.microglia_like.phagocytic_redox	7.50	Significant	—	0.36	—	0	0
59	PLAT.adhesion	7.38	Significant	—	0.00	Relevant	0	0
60	MAC.kupffer.fibrogenic	7.37	Significant	—	1.50	Relevant	0	0
61	HEP.periportal_metabolic.urea_onecarbon_secretory	7.21	Significant	2.93e-03	1.62	Specific	1,332	3,053
62	IPSC.stress	6.95	Significant	0.69	1.07	Relevant	0	0
63	EC.liver_sinusoidal.secretory_lipoprotein	6.81	Significant	0.04	1.89	Relevant	120	70
64	HEP.periportal_metabolic.xenobiotic_detox	6.75	Significant	2.93e-03	1.65	Specific	1,440	139
65	EC.liver_sinusoidal.inflammatory	6.37	Significant	—	0.24	Relevant	223	154
66	EPI.cervical_suprabasal.secretory_vesicle	6.11	Significant	—	0.00	Relevant	0	0
67	NEU.EXC_CT.Ca2_sensor	5.97	Significant	—	1.59	Relevant	0	0
68	EPI.renal_principal_cell.inflammatory	5.95	Significant	0.14	1.90	Relevant	74	157
69	MG.phagocytic_APC	5.92	Significant	0.40	1.46	Relevant	25	8
70	EPI.renal_intercalated_cell_type_A.PC_transitional	5.86	Significant	—	0.04	Other	203	407
71	EPI.renal_distal_tubule.stress	5.85	Significant	—	0.76	Relevant	0	0
72	MONO.CD14.cord_tolerance	5.77	Significant	1.00	0.00	Other	864	753
73	EPI.renal_distal_tubule.ion_transport	5.72	Significant	—	0.53	Relevant	0	0
74	MAC.resident_cardiac.phagocytic_homeostasis	5.70	Significant	0.60	1.08	Relevant	564	1,221
75	HEP.periportal_metabolic.canonical_urea_cycle	5.65	Significant	0.98	0.97	Other	1,464	269
76	EPI.renal_principal_cell.activated_acute	5.58	Significant	0.17	1.67	Relevant	29	59
77	MAC.kupffer.tolerogenic	5.58	Significant	—	0.68	—	45	49
78	MAC.kupffer.inflammatory	5.53	Significant	—	0.55	Relevant	7	4
79	EPI.endocervical_secretory.squamous_barrier	5.42	Nominal	—	0.67	Relevant	0	0
80	EC.liver_sinusoidal.remodeling_lipotoxicity	5.39	Nominal	—	0.00	Other	90	58
81	EPI.renal_principal_cell.injury_repair	5.29	Nominal	0.66	1.13	Other	26	9
82	IPSC.neural_primed	5.22	Nominal	0.69	1.05	Other	0	0
83	MAC.microglia_like.patrolling_adhesive	5.11	Nominal	—	0.00	Other	0	0
84	B.memory.pDC_imprint	5.03	Nominal	0.66	1.16	Other	157	103
85	EPI.renal_distal_tubule.repair	4.91	Nominal	—	0.00	Other	34	102
86	MAC.resident_cardiac.antigen_presenting	4.90	Nominal	0.92	0.49	Other	52	27
87	HEP.periportal_metabolic.apolipoprotein_secretory	4.84	Nominal	1.00	0.67	Other	43	110
88	HEP.periportal_metabolic.inflammatory_activated	4.83	Nominal	0.76	1.10	Other	712	1,610
89	EPI.renal_immature_ureteric_bud.osmoprotective	4.70	Nominal	0.47	1.33	Other	126	44
90	EPI.renal_intercalated_cell_type_B.baseline	4.64	Nominal	—	0.00	Other	3	1
91	EPI.renal_immature_ureteric_bud.defense_secretory	4.59	Nominal	0.61	0.85	Other	45	76
92	MAC.resident_iron.redox_metabolic	4.55	Nominal	0.95	0.42	Other	4	4
93	MG.baseline	4.50	Nominal	0.87	0.57	Other	16	5
94	EPI.ectocervical_granular.inflammatory	4.31	Nominal	—	0.32	Other	0	0
95	MG.expanding	4.15	Nominal	0.87	0.69	Other	2	1
96	EC.venous.adipose_lipid	4.09	Nominal	0.41	1.43	Other	254	476
97	DC.cDC2.lipid_metabolic	4.05	Nominal	—	0.00	Other	0	0
98	B.memory.baseline	4.02	Nominal	2.89e-05	1.71	Other	472	99
99	EPI.cervical_suprabasal.inflammatory_repair	3.92	Nominal	—	0.00	Other	0	0
100	EC.capillary.postcap_venule	3.87	Nominal	0.12	1.60	Other	355	261
101	EC.venous.activated	3.85	Nominal	0.41	1.30	Other	247	752
102	EPI.renal_distal_tubule.immune_modulatory	3.77	Nominal	—	0.00	Other	0	0
103	B.age_associated.migratory	3.76	Nominal	0.26	1.29	Other	2	2
104	EC.capillary.migratory	3.74	Nominal	0.20	1.53	Other	181	509
105	EPI.renal_thick_ascending_limb.barrier_repair	3.66	Nominal	0.10	1.76	Other	141	284
106	EPI.renal_principal_cell.canonical_vasopressin	3.64	Nominal	1.00	0.24	Other	2	0
107	EC.liver_sinusoidal.prostanoid	3.62	Nominal	—	0.00	Other	11	64
108	EC.capillary.angiocrine	3.59	Nominal	0.75	1.08	Other	250	630
109	B.age_associated.activated	3.58	Nominal	—	5.55e-17	Other	18	22
110	IPSC.mesodermal_primed	3.56	Nominal	1.00	0.98	Other	0	0
111	EC.venous.remodeling_stalk	3.54	Nominal	0.63	1.17	Other	559	566
112	EC.liver_sinusoidal.hypoxia_metabolic	3.52	Nominal	0.98	0.14	Other	183	107
113	EC.capillary.baseline	3.34	Nominal	0.73	1.14	Other	246	560
114	EC.venous.baseline	3.27	Nominal	1.00	0.65	Other	346	807
115	EC.venous.quiescent_homeostatic	3.26	Nominal	1.00	0.83	Other	456	360
116	GRNLSA.EMT_insulin_signaling	3.26	Nominal	0.04	1.97	Other	47	84
117	EPI.renal_principal_cell.intercalated_like	3.26	Nominal	1.00	0.00	Other	63	66
118	MAC.kupffer.stress	3.25	Nominal	0.84	0.57	Other	9	3
119	DC.cDC1.homeostatic_inhibitory	3.22	Nominal	—	1.01	Other	0	0
120	EPI.renal_thick_ascending_limb.remodeling	3.17	Nominal	0.41	1.38	Other	152	92
121	EPI.alveolar_type_2.stress_response	3.16	Nominal	5.11e-06	2.59	Other	675	1,562
122	DC.pDC.baseline	3.14	Nominal	0.40	1.18	Other	88	123
123	DC.pDC.immature_metabolic	2.98	Nonsignificant	0.40	1.16	Other	78	124
124	HEP.periportal_metabolic.acute_phase_barrier	2.95	Nonsignificant	1.00	0.50	Other	533	138
125	EC.capillary.stress	2.90	Nonsignificant	0.98	0.70	Other	44	36
126	EPI.renal_thick_ascending_limb.canonical_salt_transporter	2.89	Nonsignificant	0.89	0.96	Other	322	317
127	EPI.colonocyte.ionocyte_BEST4	2.85	Nonsignificant	0.12	1.58	Other	103	188
128	EPI.salivary_mucous_acinar.baseline	2.83	Nonsignificant	—	—	Other	394	683
129	EPI.colonocyte.distal_absorptive	2.81	Nonsignificant	—	1.06	Other	0	0
130	EPI.renal_intercalated_cell_type_A.acid_secretion	2.79	Nonsignificant	0.89	0.54	Other	12	6
131	B.age_associated.naive_transitional	2.76	Nonsignificant	—	0.00	Other	0	0
132	B.memory.migratory	2.73	Nonsignificant	1.00	0.71	Other	123	208
133	EPI.colonocyte.junction_remodeling	2.73	Nonsignificant	0.02	1.73	Other	218	305
134	GRNLSA.secretory_remodeling	2.73	Nonsignificant	0.88	1.03	Other	90	25
135	NEU.EXC_CT.remodeling	2.69	Nonsignificant	—	0.10	Other	23	1
136	HEP.periportal_metabolic.stress_chaperone	2.69	Nonsignificant	—	0.00	Other	66	128
137	MAC.kupffer.monocyte_like	2.67	Nonsignificant	—	0.00	Other	0	0
138	GRNLSA.cholesterol_mevalonate	2.66	Nonsignificant	0.88	1.06	Other	9	4
139	EC.capillary.inflammatory	2.66	Nonsignificant	0.98	0.51	Other	27	51
140	EPI.endocervical_secretory.secretory_translocon	2.60	Nonsignificant	—	0.00	Other	0	0
141	GRNLSA.p53_damage	2.54	Nonsignificant	—	0.13	Other	13	10
142	EPI.esophageal_suprabasal.proliferative_S	2.54	Nonsignificant	—	0.98	Other	26	41
143	EPI.esophageal_suprabasal.proliferative_exit	2.52	Nonsignificant	—	1.15	Other	0	0
144	EPI.esophageal_suprabasal.proliferative_G2M	2.52	Nonsignificant	—	0.99	Other	0	0
145	GRNLSA.lipid_hypoxia	2.48	Nonsignificant	0.88	0.90	Other	28	0
146	EC.capillary.activated	2.42	Nonsignificant	0.98	0.38	Other	2	5
147	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.35	Nonsignificant	—	1.35	Other	105	368
148	EPI.alveolar_type_2.baseline_surfactant	2.35	Nonsignificant	1.00	0.44	Other	64	9
149	EPI.ectocervical_granular.proliferative_basal	2.34	Nonsignificant	—	0.00	Other	0	0
150	MAC.kupffer.metabolic	2.32	Nonsignificant	—	0.00	Other	25	36
151	DC.cDC1.activated	2.30	Nonsignificant	—	0.36	Other	0	0
152	EPI.ileal_goblet.stress_metallothionein	2.26	Nonsignificant	—	0.37	Other	4	11
153	EPI.renal_thick_ascending_limb.cation_flux	2.26	Nonsignificant	0.99	0.47	Other	57	95
154	NEU.EXC_IT.adhesion	2.26	Nonsignificant	0.06	1.26	Other	252	108
155	NEU.EXC_CT.Ca2_signaling	2.26	Nonsignificant	—	0.26	Other	68	17
156	EC.capillary.angiogenic_tip	2.21	Nonsignificant	0.98	0.65	Other	186	218
157	HEP.pericentral_lipoprotein.UPR_redox	2.15	Nonsignificant	—	0.67	Other	0	0
158	EPI.ileal_goblet.inflammatory_mucin	2.15	Nonsignificant	0.84	0.53	Other	6	9
159	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.15	Nonsignificant	—	1.16	Other	0	0
160	EPI.ileal_goblet.baseline	2.12	Nonsignificant	0.84	0.82	Other	16	2
161	EPI.esophageal_suprabasal.basal_transitional	2.10	Nonsignificant	1.00	0.98	Other	44	67
162	EPI.pancreatic_ductal_perivascular.protective_antioxidant	2.07	Nonsignificant	—	0.72	Other	11	69
163	DC.cDC1.cross_presenting	2.06	Nonsignificant	—	0.00	Other	0	0
164	GRNLSA.stress_metabolic	2.04	Nonsignificant	—	0.00	Other	1	2
165	EC.lymphatic.tip_migratory	2.02	Nonsignificant	0.20	1.63	Other	23	37
166	B.naive.remodeling	2.01	Nonsignificant	0.22	1.26	Other	135	230
167	EC.lymphatic.activated	1.97	Nonsignificant	0.20	1.59	Other	47	73
168	MAC.resident_iron.stress_tolerogenic	1.93	Nonsignificant	—	0.00	Other	0	0
169	GRNLSA.proliferative_migratory	1.93	Nonsignificant	0.97	0.35	Other	248	292
170	B.memory.activated	1.93	Nonsignificant	1.00	0.45	Other	105	29
171	DC.cDC1.proliferative	1.90	Nonsignificant	—	0.00	Other	0	0
172	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.85	Nonsignificant	—	1.15	Other	0	0
173	EPI.renal_thick_ascending_limb.salt_sensing	1.83	Nonsignificant	0.99	0.05	Other	73	103
174	HEP.pericentral_lipoprotein.ApoB_coagulation	1.81	Nonsignificant	—	0.00	Other	0	0
175	B.naive.receptor_recycle	1.80	Nonsignificant	0.86	0.92	Other	51	0
176	GRNLSA.chemokine_mechanosensory	1.80	Nonsignificant	0.97	0.49	Other	1	0
177	EPI.pancreatic_ductal_perivascular.baseline	1.80	Nonsignificant	0.90	0.16	Other	1	5
178	EPI.alveolar_type_2.injury_primed	1.79	Nonsignificant	1.00	0.09	Other	434	245
179	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.76	Nonsignificant	—	0.73	Other	0	0
180	OLG.reactive_repair	1.73	Nonsignificant	3.37e-03	1.20	Other	385	385
181	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.64	Nonsignificant	0.37	1.35	Other	40	191
182	EPI.pancreatic_ductal_progenitor.baseline	1.63	Nonsignificant	0.85	0.49	Other	179	702
183	B.naive.purinergic	1.63	Nonsignificant	0.62	1.07	Other	384	820
184	B.naive.proteostasis	1.61	Nonsignificant	0.22	1.37	Other	49	69
185	EPI.esophageal_suprabasal.differentiating_keratin	1.59	Nonsignificant	1.00	0.00	Other	131	61
186	EPI.renal_distal_tubule.ciliated_remodelling	1.58	Nonsignificant	—	0.00	Other	0	0
187	EC.lymphatic.baseline	1.56	Nonsignificant	0.74	0.92	Other	38	72
188	B.naive.antigen_presenting_ready	1.56	Nonsignificant	0.52	1.15	Other	48	73
189	EC.arterial.inflammatory	1.55	Nonsignificant	0.32	1.28	Other	63	50
190	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.54	Nonsignificant	0.05	2.10	Other	2	9
191	EC.arterial.angiogenic_tip	1.53	Nonsignificant	—	0.60	Other	30	37
192	EPI.skin_sebaceous_duct_luminal.immune_interface	1.51	Nonsignificant	—	0.67	Other	0	0
193	ASTRO.hypoxia_angiogenic	1.51	Nonsignificant	0.59	1.37	Other	5	18
194	IPSC.canonical_pluripotent	1.49	Nonsignificant	1.00	0.88	Other	0	0
195	EPI.tracheal_suprabasal.transitional_wound	1.49	Nonsignificant	—	0.43	Other	16	1
196	B.naive.metabolic	1.47	Nonsignificant	0.69	1.05	Other	50	79
197	DC.mig.baseline	1.46	Nonsignificant	—	0.00	Other	1	0
198	ASTRO.stress_acute	1.46	Nonsignificant	0.01	1.51	Other	60	56
199	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.45	Nonsignificant	—	1.14	Other	49	237
200	IPSC.endoderm_primed	1.45	Nonsignificant	1.00	0.78	Other	0	0
201	EPI.tracheal_basal.homeostatic_progenitor	1.43	Nonsignificant	2.52e-03	2.53	Other	285	74
202	EPI.skin_hair_follicle_bulge.quiescent	1.41	Nonsignificant	0.37	1.19	Other	56	69
203	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.41	Nonsignificant	—	0.19	Other	29	88
204	EPI.skin_keratinocyte_progenitor.activated_stress	1.41	Nonsignificant	—	0.00	Other	0	0
205	EC.arterial.mito_contact	1.37	Nonsignificant	0.32	1.29	Other	14	5
206	EPI.colonocyte.secretory_boost	1.35	Nonsignificant	0.82	1.01	Other	98	91
207	EPI.pancreatic_ductal_progenitor.ADM_like	1.33	Nonsignificant	—	0.00	Other	0	0
208	EPI.skin_interfollicular_spinous.stress_UPR	1.33	Nonsignificant	—	0.75	Other	0	0
209	EPI.skin_keratinocyte_basal.basement_anchoring	1.31	Nonsignificant	—	0.97	Other	0	0
210	EC.arterial.arteriole_interface	1.31	Nonsignificant	0.32	1.31	Other	31	12
211	EC.lymphatic.scavenger	1.30	Nonsignificant	0.99	0.01	Other	203	257
212	EPI.ectocervical_granular.secretory_apocrine	1.29	Nonsignificant	—	0.00	Other	0	0
213	EPI.skin_interfollicular_spinous.transition_basal	1.28	Nonsignificant	0.39	1.48	Other	100	127
214	IPSC.neuroendocrine_primed	1.27	Nonsignificant	—	0.30	Other	0	0
215	EPI.skin_follicular_keratinizing.upper_infundibulum	1.27	Nonsignificant	—	0.58	Other	8	2
216	EPI.gastric_foveolar.baseline	1.27	Nonsignificant	—	0.00	Other	0	0
217	EPI.esophageal_basal.junctional_barrier	1.24	Nonsignificant	—	0.32	Other	0	0
218	EPI.skin_hair_follicle_bulge.anagen_growth	1.23	Nonsignificant	—	0.00	Other	0	0
219	EPI.skin_sebaceous_duct_luminal.detox_repair	1.22	Nonsignificant	1.00	0.00	Other	137	94
220	EPI.skin_interfollicular_spinous.early_differentiation	1.21	Nonsignificant	0.39	1.30	Other	89	19
221	EPI.colonocyte.crypt_progenitor	1.20	Nonsignificant	1.00	0.54	Other	115	265
222	EPI.ileal_enterocyte_absorptive.brush_border	1.18	Nonsignificant	6.06e-07	2.68	Other	580	1,717
223	NEU.EXC_CT.projector	1.18	Nonsignificant	1.00	0.00	Other	87	26
224	HEP.acute_phase.complement_metabolic	1.18	Nonsignificant	0.06	1.74	Other	1,423	3,464
225	B.naive.activated	1.17	Nonsignificant	0.86	0.92	Other	77	127
226	DC.pDC.poised_migratory	1.17	Nonsignificant	0.97	0.49	Other	54	95
227	EPI.skin_follicular_keratinizing.transit_amplifying	1.17	Nonsignificant	—	0.00	Other	21	49
228	EPI.lung_club_secretory.ciliogenesis_primed	1.16	Nonsignificant	—	0.79	Other	0	0
229	EC.arterial.arteriole_gas_exchange	1.14	Nonsignificant	0.71	1.03	Other	238	131
230	HEP.periportal_metabolic.stress_checkpoint	1.14	Nonsignificant	1.00	0.00	Other	234	786
231	HEP.acute_phase.inflammatory	1.14	Nonsignificant	0.53	1.17	Other	382	649
232	EPI.ileal_goblet.immature	1.13	Nonsignificant	—	0.00	Other	0	0
233	B.naive.baseline	1.13	Nonsignificant	0.88	0.78	Other	10	13
234	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.12	Nonsignificant	—	0.41	Other	19	54
235	EC.arterial.metabolic	1.12	Nonsignificant	0.59	1.10	Other	195	159
236	EPI.skin_interfollicular_spinous.baseline	1.11	Nonsignificant	0.92	0.37	Other	35	3
237	EPI.lung_club_secretory.inflammatory	1.08	Nonsignificant	—	0.37	Other	0	0
238	HEP.acute_phase.stress_secretory	1.05	Nonsignificant	0.27	1.57	Other	26	3
239	NEU.EXC_SYT2.synaptic	1.05	Nonsignificant	—	0.00	Other	0	0
240	EPI.tracheal_suprabasal.secretory_immune	1.05	Nonsignificant	—	0.00	Other	0	0
241	EC.lymphatic.valve	1.04	Nonsignificant	—	0.00	Other	0	0
242	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.03	Nonsignificant	—	0.00	Other	0	0
243	EPI.esophageal_basal.activated_progenitor	1.03	Nonsignificant	0.49	0.99	Other	1	0
244	EPI.skin_interfollicular_spinous.upper_lipid	1.01	Nonsignificant	—	0.00	Other	6	6
245	EPI.pancreatic_ductal_bicarbonate.inflammatory	1.01	Nonsignificant	0.99	1.11	Other	14	32
246	EPI.skin_interfollicular_spinous.proliferative	1.00	Nonsignificant	—	0.00	Other	0	0
247	EPI.colonic_tuft.activated	0.99	Nonsignificant	—	0.42	Other	0	0
248	EPI.skin_interfollicular_spinous.inflammatory	0.98	Nonsignificant	—	0.00	Other	0	0
249	B.memory.preactivated	0.98	Nonsignificant	1.00	0.57	Other	173	174
250	EPI.skin_keratinocyte_proliferating.detox_repair	0.98	Nonsignificant	—	0.92	Other	0	0
251	NEU.EXC_SYT2.nuclear_reg	0.98	Nonsignificant	—	0.00	Other	0	0
252	EPI.colonocyte.goblet_interface	0.93	Nonsignificant	—	0.00	Other	11	21
253	EPI.tracheal_basal.activated_stress	0.93	Nonsignificant	1.00	0.00	Other	32	0
254	HEP.acute_phase.baseline	0.92	Nonsignificant	0.99	0.32	Other	946	19
255	NEU.EXC_IT.transitional	0.90	Nonsignificant	0.86	0.99	Other	237	142
256	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.90	Nonsignificant	—	0.40	Other	0	0
257	EPI.ileal_enterocyte_crypt.proliferative_S	0.88	Nonsignificant	0.45	1.39	Other	4	2
258	EPI.ileal_enterocyte_crypt.bile_transport	0.87	Nonsignificant	0.58	1.08	Other	2	0
259	EPI.colonic_tuft.homeostatic	0.86	Nonsignificant	—	0.00	Other	0	0
260	EPI.skin_follicular_keratinizing.root_infundibulum	0.86	Nonsignificant	—	0.00	Other	0	0
261	OPC.proliferative_immune_interact	0.85	Nonsignificant	0.03	1.96	Other	180	373
262	EPI.colonic_enteroendocrine.Lcell_peptide	0.85	Nonsignificant	—	0.97	Other	0	0
263	EPI.lung_club_secretory.ciliogenesis_axoneme	0.83	Nonsignificant	—	0.00	Other	0	0
264	HEP.acute_phase.complement_antiviral	0.82	Nonsignificant	0.99	0.34	Other	377	751
265	FIB.neurolectin_mucosa.inflammatory	0.82	Nonsignificant	0.32	1.20	Other	52	110
266	FIB.neurolectin_mucosa.axon_responsive	0.81	Nonsignificant	0.32	1.29	Other	10	10
267	ASTRO.A1_reactive	0.79	Nonsignificant	0.02	1.42	Other	433	394
268	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.78	Nonsignificant	—	0.78	Other	6	9
269	EPI.skin_interfollicular_spinous.stress_oxidative	0.76	Nonsignificant	—	0.00	Other	0	0
270	EPI.ileal_enterocyte_crypt.baseline	0.76	Nonsignificant	0.58	0.94	Other	11	6
271	HEP.acute_phase.proliferative	0.75	Nonsignificant	—	0.00	Other	4	6
272	OPC.homeostatic	0.75	Nonsignificant	0.86	0.91	Other	394	160
273	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.71	Nonsignificant	—	0.00	Other	135	290
274	EC.arterial.ion_pump	0.71	Nonsignificant	0.94	0.74	Other	3	2
275	EPI.bile_duct_cholangiocyte.secretory_mucin	0.70	Nonsignificant	—	0.62	Other	7	12
276	OPC.premyelinating	0.69	Nonsignificant	0.91	0.47	Other	185	12
277	FIB.neurolectin_mucosa.nerve_interface	0.66	Nonsignificant	—	0.00	Other	4	0
278	EPI.lung_club_secretory.canonical_surfactant	0.63	Nonsignificant	—	0.00	Other	74	104
279	EPI.skin_keratinocyte_basal.transit_amplifying	0.59	Nonsignificant	—	0.00	Other	0	0
280	EPI.hepatic_ductular_cholangiocyte.stress	0.59	Nonsignificant	—	0.40	Other	0	0
281	EC.arterial.elastic	0.56	Nonsignificant	0.76	0.97	Other	22	45
282	EPI.ileal_enterocyte_crypt.villus_transition	0.56	Nonsignificant	—	0.00	Other	7	10
283	EPI.pancreatic_ductal_bicarbonate.stress	0.55	Nonsignificant	—	0.00	Other	12	33
284	EPI.colonocyte.proximal_transport	0.54	Nonsignificant	1.00	0.05	Other	24	12
285	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.53	Nonsignificant	—	1.29	Other	10	20
286	FIB.neurolectin_mucosa.remodeling_repair	0.53	Nonsignificant	—	0.00	Other	4	2
287	DC.cDC1.baseline	0.52	Nonsignificant	—	0.00	Other	0	0
288	EPI.ileal_enterocyte_absorptive.villus_tip	0.51	Nonsignificant	1.00	0.00	Other	4	3
289	SMC.activated	0.51	Nonsignificant	0.07	1.33	Other	2	5
290	NEU.EXC_IT.guidance	0.49	Nonsignificant	0.86	0.99	Other	274	63
291	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.48	Nonsignificant	—	0.09	Other	0	0
292	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.47	Nonsignificant	0.01	2.07	Other	33	34
293	FIB.suburothelial.homeostasis_matrix	0.47	Nonsignificant	0.33	1.55	Other	258	921
294	FIB.suburothelial.inflammatory_prostanoid	0.47	Nonsignificant	—	0.51	Other	0	0
295	FIB.suburothelial.contractile_myofibroblast	0.47	Nonsignificant	—	0.50	Other	9	0
296	EPI.ileal_bile_transport.absorptive_xenobiotic	0.46	Nonsignificant	0.14	1.75	Other	11	12
297	EC.venous.cardiac_structural	0.45	Nonsignificant	1.00	0.00	Other	102	229
298	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.45	Nonsignificant	—	0.54	Other	0	0
299	NEU.INH_PVALB.neuromodulatory	0.45	Nonsignificant	—	1.94	Other	0	0
300	B.naive.restrained	0.43	Nonsignificant	0.88	0.89	Other	183	353
301	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.43	Nonsignificant	0.16	1.27	Other	11	22
302	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.43	Nonsignificant	—	0.00	Other	0	0
303	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.42	Nonsignificant	—	1.13	Other	43	26
304	FIB.barrier_secretory.homeostasis	0.41	Nonsignificant	—	0.25	Other	0	0
305	HPC.GMP_inflammatory	0.41	Nonsignificant	0.40	1.29	Other	20	10
306	EPI.skin_appendage_keratinocyte.transit_amplifying	0.40	Nonsignificant	—	0.17	Other	109	358
307	EPI.skin_keratinocyte_basal.spinous_transition	0.39	Nonsignificant	—	0.00	Other	0	0
308	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.39	Nonsignificant	—	0.97	Other	0	0
309	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.39	Nonsignificant	—	0.00	Other	0	0
310	EPI.extrahepatic_cholangiocyte.barrier_interface	0.39	Nonsignificant	—	0.00	Other	0	0
311	EPI.pancreatic_ductal_bicarbonate.activated	0.38	Nonsignificant	0.99	0.87	Other	10	7
312	FIB.suburothelial.urothelial_interface	0.38	Nonsignificant	0.90	0.31	Other	9	8
313	EPI.ileal_bile_transport.detox_transcytosis	0.38	Nonsignificant	—	0.00	Other	0	1
314	IPSC.mesendo_primed	0.38	Nonsignificant	1.00	0.90	Other	0	0
315	EPI.skin_hair_follicle_companion.activated_migratory	0.37	Nonsignificant	—	0.00	Other	0	0
316	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.37	Nonsignificant	—	0.00	Other	0	0
317	MUSC.activated_migratory	0.37	Nonsignificant	0.22	1.70	Other	6	7
318	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.36	Nonsignificant	—	0.00	Other	5	3
319	MUSC.early_activation	0.35	Nonsignificant	0.74	1.14	Other	4	32
320	EPI.thymic_medullary.canonical_alarmin	0.35	Nonsignificant	0.11	1.74	Other	8	17
321	HEP.canalicular_transport.ductular_like_transition	0.34	Nonsignificant	0.19	1.47	Other	400	87
322	IPSC.stromal_primed	0.34	Nonsignificant	1.00	0.76	Other	0	0
323	NEU.EXC_IT.callosal	0.34	Nonsignificant	0.86	1.02	Other	286	119
324	PERI.inflammatory	0.34	Nonsignificant	0.04	1.20	Other	40	77
325	ASTRO.immature_lipid	0.33	Nonsignificant	1.00	0.84	Other	23	113
326	FIB.barrier_purinergic.lipid_secretory	0.33	Nonsignificant	—	0.48	Other	0	0
327	NEU.INH_VIP.cannabinoid	0.33	Nonsignificant	—	1.91	Other	0	0
328	SKM.type_1_slow.glycolytic	0.33	Nonsignificant	2.18e-03	1.97	Other	362	647
329	MESO.antiviral	0.32	Nonsignificant	—	1.11	Other	3	8
330	ASPC.mesothelial_like	0.32	Nonsignificant	7.19e-05	1.44	Other	143	486
331	HEP.canalicular_transport.secretory_ERAD_UPR	0.31	Nonsignificant	0.46	1.28	Other	232	28
332	EPI.ileal_enterocyte_crypt.secretory_precursor	0.31	Nonsignificant	—	0.00	Other	0	0
333	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.31	Nonsignificant	—	0.00	Other	39	82
334	EPI.thymic_medullary.stress_APC	0.30	Nonsignificant	0.35	1.15	Other	2	4
335	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.30	Nonsignificant	—	0.58	Other	0	0
336	ASTRO.homeostatic	0.30	Nonsignificant	1.00	0.93	Other	200	431
337	PERI.baseline	0.30	Nonsignificant	0.10	1.13	Other	39	66
338	MUSC.baseline	0.30	Nonsignificant	0.74	0.95	Other	0	0
339	HEP.canalicular_transport.injury_stress	0.29	Nonsignificant	0.71	1.10	Other	289	24
340	EPI.thymic_medullary.proliferative_APC	0.28	Nonsignificant	—	0.00	Other	0	0
341	EC.arterial.homeostatic	0.28	Nonsignificant	1.00	0.15	Other	24	3
342	SCHWN.translation_boost	0.27	Nonsignificant	—	0.27	Other	8	1
343	EPI.tracheal_submucosal_gland.ductal_luminal	0.27	Nonsignificant	—	0.00	Other	0	0
344	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.27	Nonsignificant	1.00	0.00	Other	7	16
345	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	0.26	Nonsignificant	—	0.00	Other	0	0
346	HEP.acute_phase.hypoxia_lipid	0.26	Nonsignificant	—	0.00	Other	0	0
347	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.26	Nonsignificant	—	0.00	Other	2	0
348	EPI.tracheal_submucosal_gland.acinar_serous	0.25	Nonsignificant	—	0.00	Other	0	0
349	GRANU.MAST.activated_acute	0.24	Nonsignificant	—	0.62	Other	0	0
350	EPI.thymic_medullary.hormone_xeno_barrier	0.24	Nonsignificant	—	0.00	Other	0	8
351	ASTRO.synaptic_interaction	0.23	Nonsignificant	1.00	0.63	Other	76	334
352	FIB.perivascular_interface.vasomotor_tone	0.23	Nonsignificant	—	0.32	Other	0	0
353	IPSC.proliferative	0.23	Nonsignificant	1.00	0.68	Other	0	0
354	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.22	Nonsignificant	—	0.00	Other	0	0
355	HEP.canalicular_transport.inflammatory	0.22	Nonsignificant	1.00	0.71	Other	1,335	194
356	SMC.metabolic	0.22	Nonsignificant	0.68	0.93	Other	14	40
357	ASPC.activated	0.22	Nonsignificant	0.04	1.22	Other	164	162
358	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.22	Nonsignificant	—	0.09	Other	0	0
359	SCHWN.reactive_inflammatory	0.22	Nonsignificant	—	0.85	Other	0	0
360	MUSC.quiescent_reservoir	0.21	Nonsignificant	0.90	0.44	Other	2	8
361	EPI.hepatic_ductular_cholangiocyte.polarity	0.21	Nonsignificant	—	0.00	Other	0	0
362	FIB.lung_alveolar.stress_interacting	0.21	Nonsignificant	—	0.00	Other	0	0
363	NEU.INH_PVALB.serotonergic	0.21	Nonsignificant	—	0.48	Other	0	0
364	ASTRO.stress_mito	0.21	Nonsignificant	1.00	0.62	Other	47	110
365	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.21	Nonsignificant	—	0.00	Other	0	0
366	GRANU.MAST.resting_granule	0.20	Nonsignificant	—	0.44	Other	0	0
367	NEU.INH_PVALB.fastspike	0.20	Nonsignificant	—	0.42	Other	24	22
368	NEU.INH_VIP.enkephalinergic	0.19	Nonsignificant	—	0.83	Other	0	0
369	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.19	Nonsignificant	—	0.00	Other	0	0
370	FIB.perivascular_interface.vascular_BM_remodelling	0.19	Nonsignificant	—	0.00	Other	0	0
371	PC.IgA_muocsal.baseline	0.19	Nonsignificant	0.46	1.22	Other	3	5
372	FIB.lung_alveolar.mito_secretory	0.19	Nonsignificant	—	0.00	Other	0	0
373	HEP.canalicular_transport.pericentral_like_hypoxia	0.19	Nonsignificant	0.78	1.00	Other	326	8
374	FIB.adventitial.adhesion_lipid	0.19	Nonsignificant	1.00	1.07	Other	58	209
375	SMC.contractile	0.19	Nonsignificant	0.68	0.98	Other	80	588
376	EPI.pancreatic_ductal_bicarbonate.baseline	0.16	Nonsignificant	0.99	0.54	Other	11	42
377	FIB.tracheal_subepithelial.baseline	0.16	Nonsignificant	—	0.00	Other	0	0
378	PC.IgA_muocsal.activated	0.16	Nonsignificant	0.87	1.01	Other	17	8
379	HPC.CLP_B_primed	0.16	Nonsignificant	—	0.83	Other	0	0
380	FIB.perivascular_interface.lipid_shuttle	0.15	Nonsignificant	—	0.00	Other	51	170
381	SKM.type_1_slow.contractile	0.15	Nonsignificant	0.99	0.50	Other	596	8
382	OLG.vesicle_trafficking	0.15	Nonsignificant	1.00	0.98	Other	124	10
383	SKM.type_1_slow.oxidative	0.14	Nonsignificant	0.99	0.27	Other	802	251
384	PERI.angiocrine	0.14	Nonsignificant	0.49	1.03	Other	93	102
385	NEU.INH_VIP.serotonergic	0.14	Nonsignificant	—	0.27	Other	9	2
386	PC.IgA_muocsal.migratory	0.14	Nonsignificant	0.87	0.84	Other	4	1
387	OLG.stress	0.14	Nonsignificant	1.00	0.97	Other	232	8
388	FIB.barrier_purinergic.stress_GF_binding	0.13	Nonsignificant	—	0.00	Other	0	0
389	PC.IgG_systemic.secretory	0.13	Nonsignificant	0.06	1.56	Other	0	0
390	NEU.INH_VIP.matrix	0.13	Nonsignificant	—	0.14	Other	24	77
391	EPI.skin_sweat_duct_keratinocyte.repair	0.13	Nonsignificant	—	0.00	Other	0	0
392	NEU.INH_VIP.excitatory_coupled	0.13	Nonsignificant	—	0.08	Other	13	0
393	EC.heart_remodeling.remodeling_secretory	0.12	Nonsignificant	0.07	1.14	Other	605	1,341
394	MESO.baseline	0.12	Nonsignificant	0.77	0.79	Other	0	6
395	MESO.activated_migratory	0.12	Nonsignificant	—	0.00	Other	0	0
396	FIB.skin_neurosecretory.baseline	0.12	Nonsignificant	—	0.00	Other	0	0
397	PC.IgA_muocsal.plasmablast	0.11	Nonsignificant	0.87	0.67	Other	5	4
398	OLG.myelinating_stress	0.11	Nonsignificant	1.00	0.94	Other	232	62
399	HEP.canalicular_transport.baseline	0.11	Nonsignificant	1.00	0.17	Other	199	477
400	NEU.INH_VIP.opioid	0.11	Nonsignificant	—	0.00	Other	50	9
401	NEU.INH_VIP.regulatory_remodeling	0.11	Nonsignificant	—	0.00	Other	6	1
402	NEU.INH_PVALB.metabotropic	0.11	Nonsignificant	—	0.00	Other	0	0
403	NEU.INH_VIP.canonical_disinhibitory	0.11	Nonsignificant	0.78	0.66	Other	59	38
404	EPI.salivary_intercalated_defense.inflammatory	0.10	Nonsignificant	0.98	0.51	Other	152	360
405	NEU.INH_VIP.develop_niche	0.10	Nonsignificant	—	0.00	Other	0	0
406	ASPC.inflammatory	0.10	Nonsignificant	0.82	1.05	Other	21	61
407	ASTRO.neuromodulatory	0.10	Nonsignificant	1.00	0.34	Other	34	172
408	NEU.EXC_NTNG1.synaptic	0.09	Nonsignificant	—	0.67	Other	0	0
409	FIB.reticular.stromal_niche	0.08	Nonsignificant	0.03	1.54	Other	0	0
410	ASTRO.A2_reactive	0.08	Nonsignificant	1.00	0.33	Other	10	37
411	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.08	Nonsignificant	0.99	0.44	Other	219	533
412	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.08	Nonsignificant	—	0.00	Other	0	0
413	IPSC.axial_identity_primed	0.08	Nonsignificant	1.00	0.64	Other	0	0
414	NEU.INH_PVALB.chandelier	0.08	Nonsignificant	0.70	0.86	Other	19	16
415	FIB.interstitial.immune_interact	0.08	Nonsignificant	0.82	1.13	Other	12	1
416	NEU.INH_PVALB.nuclear_reg	0.08	Nonsignificant	0.70	0.83	Other	25	12
417	ASPC.preadipocyte_lipid_primed	0.08	Nonsignificant	0.19	1.08	Other	331	129
418	NEU.INH_VIP.LAMP5_hybrid	0.08	Nonsignificant	—	0.00	Other	1	9
419	OLG.myelinating_mature	0.08	Nonsignificant	1.00	0.83	Other	363	94
420	EPI.lung_multiciliated.stress	0.07	Nonsignificant	—	0.61	Other	67	165
421	HPC.MPP_IEG	0.07	Nonsignificant	0.91	1.01	Other	45	46
422	EPI.thymic_cortical.Notch_interface	0.07	Nonsignificant	—	1.07	Other	82	137
423	HPC.LMPP	0.07	Nonsignificant	0.91	0.89	Other	65	31
424	FIB.interstitial.mesenchymal_regulator	0.07	Nonsignificant	0.82	1.10	Other	4	4
425	EPI.salivary_duct_ion_transport.baseline	0.06	Nonsignificant	—	—	Other	0	0
426	NEU.INH_VIP.nuclear_reg	0.06	Nonsignificant	—	0.00	Other	20	4
427	EPI.thymic_cortical.baseline	0.06	Nonsignificant	0.27	1.33	Other	185	386
428	T.CD8_Tcm.gut_homing	0.06	Nonsignificant	0.14	1.21	Other	380	112
429	HPC.MPP_activated	0.06	Nonsignificant	—	0.27	Other	0	0
430	PC.IgG_systemic.interacting	0.06	Nonsignificant	1.00	0.71	Other	0	0
431	FIB.skin_sheath.stress_chaperone	0.06	Nonsignificant	—	0.00	Other	0	0
432	PC.IgG_systemic.stress	0.05	Nonsignificant	—	0.00	Other	1	5
433	GRANU.MAST.activated_repair	0.05	Nonsignificant	—	0.00	Other	0	1
434	MESO.activated_stress	0.05	Nonsignificant	—	0.00	Other	0	0
435	EPI.salivary_serous_acinar.quiescent	0.05	Nonsignificant	0.39	1.14	Other	178	493
436	NEU.EXC_IT.neuromodulated	0.05	Nonsignificant	1.00	0.51	Other	176	116
437	NEU.INH_LAMP5.glial_interface	0.05	Nonsignificant	—	0.76	Other	0	0
438	FIB.reticular.immune_interface	0.05	Nonsignificant	—	0.28	Other	1	6
439	NEU.INH_LAMP5.rosehip	0.04	Nonsignificant	—	0.71	Other	0	0
440	ASPC.adipocyte_capillary_interface	0.04	Nonsignificant	1.00	0.75	Other	21	54
441	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.04	Nonsignificant	—	0.00	Other	0	0
442	EPI.lung_multiciliated.baseline	0.04	Nonsignificant	—	0.00	Other	0	7
443	FIB.interstitial.remodeling	0.04	Nonsignificant	1.00	0.93	Other	31	9
444	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	0.04	Nonsignificant	—	0.00	Other	0	0
445	EPI.alveolar_type_1.activated	0.04	Nonsignificant	—	1.64	Other	0	0
446	EPI.thymic_cortical.secretory_remodeling	0.03	Nonsignificant	—	0.00	Other	4	1
447	ASPC.secretory	0.03	Nonsignificant	1.00	0.84	Other	76	5
448	FIB.adventitial.inflammatory_activated	0.03	Nonsignificant	1.00	1.04	Other	100	473
449	CM.contractile_oxphos	0.03	Nonsignificant	0.78	1.11	Other	6	19
450	ASPC.baseline	0.03	Nonsignificant	1.00	0.75	Other	363	170
451	SKM.type_2_fast.oxidative_IIa	0.03	Nonsignificant	0.02	1.26	Other	946	56
452	ASPC.remodeling	0.03	Nonsignificant	1.00	0.95	Other	106	354
453	THYMO.SP_CD8_naive_stress	0.03	Nonsignificant	0.20	1.33	Other	1	1
454	FIB.interstitial.mesenchymal_APC	0.03	Nonsignificant	1.00	0.94	Other	81	33
455	MEL.neurotrophic_migratory	0.02	Nonsignificant	—	1.74	Other	0	0
456	PC.IgG_systemic.metabolic	0.02	Nonsignificant	1.00	0.09	Other	46	63
457	T.CD4_Tfh.canonical_GC_helper	0.02	Nonsignificant	0.40	1.11	Other	1	2
458	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.02	Nonsignificant	0.04	1.59	Other	449	1,034
459	NEU.INH_LAMP5.exc_inh_balance	0.02	Nonsignificant	—	0.00	Other	46	2
460	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.02	Nonsignificant	—	0.00	Other	0	0
461	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.02	Nonsignificant	—	0.00	Other	0	0
462	EPI.skin_sweat_duct_keratinocyte.barrier	0.02	Nonsignificant	—	0.00	Other	0	0
463	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.02	Nonsignificant	—	0.10	Other	0	0
464	FIB.hepatic_stellate_cell.fibrogenic	0.02	Nonsignificant	—	0.73	Other	0	0
465	MESO.secretory_structural	0.02	Nonsignificant	—	0.00	Other	0	0
466	EPI.salivary_serous_acinar.seromucous_like	0.02	Nonsignificant	—	1.08	Other	0	0
467	NEU.INH_LAMP5.projecting	0.02	Nonsignificant	—	0.00	Other	0	0
468	HPC.GMP_granulocytic	0.01	Nonsignificant	—	0.00	Other	3	3
469	EC.heart_remodeling.remodeling_stalk	0.01	Nonsignificant	0.93	1.05	Other	33	111
470	OLG.regulatory	0.01	Nonsignificant	1.00	0.46	Other	353	73
471	ASPC.niche_keeping_progenitor	0.01	Nonsignificant	0.14	1.18	Other	52	219
472	EC.heart_remodeling.capillary_metabolic	0.01	Nonsignificant	0.90	1.18	Other	54	414
473	CHOND.remodeling	0.01	Nonsignificant	—	1.02	Other	5	0
474	NK.immature_bridge	0.01	Nonsignificant	0.70	1.03	Other	117	122
475	HPC.MEP	0.01	Nonsignificant	0.91	0.73	Other	599	1,195
476	T.CD4_transitional.APC_interacting	9.66e-03	Nonsignificant	0.46	1.17	Other	10	14
477	FIB.skin_tenogenic.baseline	9.40e-03	Nonsignificant	—	0.00	Other	0	2
478	T.CD4_Trm.central_like	9.32e-03	Nonsignificant	0.04	1.14	Other	38	31
479	FIB.interstitial.lipid_matrix	9.31e-03	Nonsignificant	1.00	0.86	Other	258	191
480	OLG.regulatory_activated	9.00e-03	Nonsignificant	1.00	0.73	Other	196	614
481	NK.cytokine_repair_primed	8.60e-03	Nonsignificant	0.21	1.10	Other	266	11
482	ILC2.quiescent	8.56e-03	Nonsignificant	—	1.03	Other	0	0
483	GRNLSA.angiocrine_mechanosensory	8.46e-03	Nonsignificant	—	0.00	Other	0	0
484	EPI.salivary_duct_excretory.baseline	8.44e-03	Nonsignificant	0.14	1.19	Other	23	57
485	EC.heart_remodeling.translation_boost	8.16e-03	Nonsignificant	—	0.54	Other	0	0
486	T.CD4_Trm.cytotoxic_effector	7.90e-03	Nonsignificant	0.69	1.08	Other	118	77
487	EPI.pancreatic_islet.alpha	7.61e-03	Nonsignificant	—	0.14	Other	152	330
488	NEU.EXC_IT.structural	6.89e-03	Nonsignificant	1.00	0.25	Other	171	41
489	EPI.pancreatic_islet.beta	6.78e-03	Nonsignificant	0.67	0.81	Other	42	57
490	FIB.reticular.stress_metallothionein	6.58e-03	Nonsignificant	—	0.00	Other	3	32
491	T.CD4_Trm.baseline	6.41e-03	Nonsignificant	0.74	1.05	Other	31	21
492	T.CD4_Tcm.migratory_cilium	6.23e-03	Nonsignificant	0.13	1.14	Other	5	10
493	SKM.type_2_fast.glycolytic_IIx_IIb	6.10e-03	Nonsignificant	0.98	0.63	Other	565	1,482
494	FIB.hepatic_stellate_cell.contractile	6.07e-03	Nonsignificant	—	0.00	Other	0	0
495	CHOND.articular_collagen	5.97e-03	Nonsignificant	0.81	1.01	Other	551	266
496	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	5.73e-03	Nonsignificant	—	0.00	Other	0	0
497	MEL.dedifferentiated_migratory	5.70e-03	Nonsignificant	—	0.35	Other	0	0
498	T.CD4_Th2.precursor	5.49e-03	Nonsignificant	—	0.00	Other	0	0
499	T.CD4_transitional.primed_helper_effector	5.16e-03	Nonsignificant	0.64	1.05	Other	19	43
500	EPI.pancreatic_acinar.stress	4.72e-03	Nonsignificant	0.55	1.26	Other	28	28
501	CHOND.activated_fibro_like	4.72e-03	Nonsignificant	0.81	1.00	Other	531	188
502	FIB.hepatic_stellate_cell.inflammatory	4.58e-03	Nonsignificant	—	0.00	Other	0	0
503	EPI.salivary_myoepithelial.contractile_repair	4.26e-03	Nonsignificant	—	1.13	Other	3	9
504	T.CD8_Trm.muscosal_Tc17	4.10e-03	Nonsignificant	0.55	1.09	Other	19	38
505	NK.adaptive_classII_inhibitory	4.04e-03	Nonsignificant	0.70	1.04	Other	880	154
506	T.CD4_Tcm.DC_interact	3.94e-03	Nonsignificant	0.34	1.11	Other	72	32
507	FIB.skin_sheath.neuro_vascular_interface	3.81e-03	Nonsignificant	—	0.44	Other	0	0
508	T.CD4_naive.homeostatic	3.81e-03	Nonsignificant	0.51	1.06	Other	215	108
509	T.CD8_Trm.inflammatory	3.60e-03	Nonsignificant	0.55	1.05	Other	124	176
510	EPI.salivary_serous_acinar.secretory_active	3.56e-03	Nonsignificant	1.00	0.71	Other	242	69
511	EC.heart_remodeling.angiocrine	3.47e-03	Nonsignificant	1.00	0.69	Other	182	525
512	THYMO.DP_early_stress	3.46e-03	Nonsignificant	—	1.39	Other	0	0
513	T.CD4_Tfh.suppression_exhaustion	3.40e-03	Nonsignificant	0.64	1.05	Other	0	2
514	T.CD4_transitional.tissue_enagement	3.39e-03	Nonsignificant	0.64	1.03	Other	5	11
515	T.CD4_transitional.baseline	3.00e-03	Nonsignificant	0.46	1.08	Other	59	97
516	THYMO.DP_early	2.99e-03	Nonsignificant	0.20	1.15	Other	326	313
517	T.CD4_Th17.migratory	2.92e-03	Nonsignificant	0.63	1.04	Other	13	23
518	THYMO.SP_CD8_transitional	2.79e-03	Nonsignificant	0.36	1.26	Other	32	75
519	THYMO.DN_preTCR	2.33e-03	Nonsignificant	0.54	1.07	Other	41	71
520	CM.baseline	2.20e-03	Nonsignificant	1.00	1.00	Other	393	0
521	T.CD8_naive.nfkb_related	2.18e-03	Nonsignificant	0.62	1.13	Other	1	0
522	T.CD4_Tcm.baseline	2.16e-03	Nonsignificant	0.39	1.11	Other	61	31
523	T.MAIT.migratory	2.13e-03	Nonsignificant	0.58	1.25	Other	10	1
524	FIB.skin_papillary.baseline	2.10e-03	Nonsignificant	—	0.00	Other	0	0
525	T.CD4_Th2.tissue_adapted	2.09e-03	Nonsignificant	—	0.00	Other	0	0
526	T.CD4_Th17.baseline	2.07e-03	Nonsignificant	0.63	1.05	Other	51	5
527	FIB.skin_sheath.ECM_immune	2.04e-03	Nonsignificant	—	0.00	Other	0	0
528	FIB.interstitial.stress_secretory	1.88e-03	Nonsignificant	1.00	0.46	Other	92	56
529	FIB.reticular.ECM_builder	1.81e-03	Nonsignificant	—	0.00	Other	0	0
530	ASPC.proliferative	1.76e-03	Nonsignificant	1.00	0.50	Other	33	85
531	FIB.transitioning.secretory_procollagen	1.75e-03	Nonsignificant	—	0.61	Other	0	0
532	PERI.cardiac_skeletal	1.72e-03	Nonsignificant	1.00	0.04	Other	313	630
533	FIB.transitioning.ISG_primed_interface	1.65e-03	Nonsignificant	—	0.08	Other	17	80
534	FIB.adventitial.activated_remodelling	1.55e-03	Nonsignificant	—	0.42	Other	141	319
535	T.CD8_transitional.early	1.55e-03	Nonsignificant	0.70	1.01	Other	327	55
536	T.CD4_Th17.cytotoxic	1.49e-03	Nonsignificant	0.63	0.99	Other	332	123
537	T.CD4_Tem.inflammatory	1.41e-03	Nonsignificant	0.73	1.03	Other	28	6
538	T.CD4_Tfh.precursor_migratory	1.37e-03	Nonsignificant	0.40	1.08	Other	72	27
539	T.CD4_Trm.activated	1.34e-03	Nonsignificant	0.79	1.00	Other	32	26
540	T.CD8_transitional.stress	1.33e-03	Nonsignificant	—	1.20	Other	24	34
541	T.CD4_Tem.long_term_memory	1.26e-03	Nonsignificant	0.73	1.05	Other	314	587
542	T.CD8_transitional.Trm_primed	1.22e-03	Nonsignificant	0.70	1.05	Other	108	15
543	T.CD4_Trm.helper_like	1.18e-03	Nonsignificant	0.79	0.95	Other	84	147
544	EPI.lung_multiciliated.mature_motile_cilia	1.09e-03	Nonsignificant	—	0.00	Other	0	0
545	T.CD8_Tem.baseline	1.01e-03	Nonsignificant	0.54	1.03	Other	458	356
546	T.CD8_transitional.effector_primed	8.83e-04	Nonsignificant	0.84	1.00	Other	435	151
547	FIB.barrier_secretory.remodeling	8.30e-04	Nonsignificant	—	0.00	Other	0	0
548	ASPC.stem_like_progenitor	8.11e-04	Nonsignificant	1.00	0.60	Other	300	842
549	THYMO.proliferative_S	7.34e-04	Nonsignificant	0.54	1.02	Other	163	418
550	T.CD4_naive.mature	7.34e-04	Nonsignificant	0.86	1.02	Other	211	100
551	NK.adaptive_HLAE_tuned	7.24e-04	Nonsignificant	0.26	1.04	Other	1,124	189
552	SCHWN.axon_contact_cardiac	6.74e-04	Nonsignificant	0.99	0.24	Other	18	63
553	T.CD8_naive.effector_transition	6.19e-04	Nonsignificant	0.82	1.05	Other	35	62
554	MEL.mature_oxidative_traffic	6.07e-04	Nonsignificant	0.94	0.67	Other	247	285
555	T.MAIT.early_activation	6.03e-04	Nonsignificant	0.58	1.22	Other	57	4
556	MEL.stress_glucocorticoid	5.85e-04	Nonsignificant	0.94	0.89	Other	11	34
557	THYMO.proliferative_G2M	5.84e-04	Nonsignificant	—	0.52	Other	164	413
558	T.CD4_Trm.metal_stress	5.64e-04	Nonsignificant	0.79	0.90	Other	34	58
559	EPI.alveolar_type_1.baseline	5.44e-04	Nonsignificant	1.00	0.00	Other	8	0
560	T.CD4_transitional.primed_cytotoxic	5.35e-04	Nonsignificant	0.77	0.92	Other	28	30
561	EPI.salivary_myoepithelial.baseline	5.21e-04	Nonsignificant	0.77	1.07	Other	42	141
562	FIB.transitioning.matrix_stress	5.08e-04	Nonsignificant	—	0.00	Other	47	138
563	T.CD8_Trm.dendritic_recruiter	5.01e-04	Nonsignificant	0.91	0.93	Other	47	85
564	T.CD8_naive.lipid_synthesis	4.93e-04	Nonsignificant	0.57	1.16	Other	6	4
565	FIB.adventitial.PI16_matrix	4.92e-04	Nonsignificant	1.00	0.93	Other	70	90
566	EPI.pancreatic_acinar.inflammatory_regenerative	4.79e-04	Nonsignificant	0.55	1.23	Other	25	113
567	EC.heart_remodeling.perivascular	4.58e-04	Nonsignificant	1.00	0.47	Other	124	408
568	T.CD4_Tcm.imprinted_splicing	4.58e-04	Nonsignificant	0.74	1.09	Other	6	17
569	EPI.colonic_enteroendocrine.progenitor	4.26e-04	Nonsignificant	—	0.00	Other	0	0
570	FIB.transitioning.motility_remodelling	4.17e-04	Nonsignificant	—	0.00	Other	0	0
571	MEL.secretory_quiescent	4.10e-04	Nonsignificant	0.94	0.58	Other	19	13
572	T.CD4_Tcm.tissue_homing	4.07e-04	Nonsignificant	0.78	1.06	Other	78	46
573	T.CD4_Tem.transitional_CM	3.93e-04	Nonsignificant	0.73	1.06	Other	31	20
574	T.CD8_naive.vesicle_secretory	3.79e-04	Nonsignificant	0.53	1.12	Other	42	0
575	T.CD8_Trm.homeostatic	3.71e-04	Nonsignificant	0.95	0.86	Other	42	5
576	NEU.EXC_NTNG1.nuclear_reg	3.69e-04	Nonsignificant	—	0.00	Other	0	0
577	T.CD4_naive.Treg_like	3.36e-04	Nonsignificant	0.73	1.21	Other	121	72
578	EPI.salivary_duct_excretory.stress	3.28e-04	Nonsignificant	0.99	0.13	Other	33	68
579	THYMO.SP_CD8_naive	3.16e-04	Nonsignificant	1.00	0.67	Other	297	177
580	T.MAIT.MAPK_brake	3.04e-04	Nonsignificant	0.95	0.96	Other	44	66
581	ILC2.activated	2.90e-04	Nonsignificant	—	0.00	Other	0	0
582	T.CD4_Tfh.effector_migratory	2.81e-04	Nonsignificant	0.93	0.82	Other	122	57
583	FIB.adventitial.complement_angiocrine	2.76e-04	Nonsignificant	1.00	0.92	Other	153	684
584	THYMO.SP_CD4_naive	2.74e-04	Nonsignificant	0.54	1.04	Other	65	75
585	CM.oxidative_phospho	2.51e-04	Nonsignificant	1.00	1.03	Other	266	792
586	T.CD4_naive.neddylation	2.49e-04	Nonsignificant	0.86	1.02	Other	104	222
587	T.CD4_Tcm.stress	2.48e-04	Nonsignificant	0.85	1.08	Other	5	11
588	CHOND.pro_inflammatory	2.42e-04	Nonsignificant	0.98	0.66	Other	181	351
589	EPI.salivary_myoepithelial.junctional_transport	2.28e-04	Nonsignificant	0.77	1.01	Other	66	121
590	T.gamma_delta.cytotoxic_effector	2.25e-04	Nonsignificant	0.23	1.06	Other	349	109
591	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	2.10e-04	Nonsignificant	—	0.00	Other	0	0
592	T.CD8_Trm.cytotoxic	2.03e-04	Nonsignificant	0.55	1.05	Other	165	85
593	NK.cytokine_lung_immediate_early	1.85e-04	Nonsignificant	0.89	1.07	Other	424	274
594	T.CD8_Tem.signaling_turnover	1.84e-04	Nonsignificant	0.54	1.06	Other	425	683
595	T.CD4_naive.proteostasis	1.76e-04	Nonsignificant	0.86	1.02	Other	14	9
596	T.CD4_naive.mature_mitoprot	1.69e-04	Nonsignificant	0.94	0.96	Other	212	476
597	T.CD8_naive.cytokine_dampened	1.66e-04	Nonsignificant	0.82	1.00	Other	71	4
598	EC.heart_remodeling.activated_acute	1.64e-04	Nonsignificant	1.00	0.62	Other	102	186
599	T.CD4_Treg.tissue_effector	1.63e-04	Nonsignificant	0.50	1.10	Other	16	13
600	T.CD4_Trm.stress_adaptive	1.54e-04	Nonsignificant	0.79	0.88	Other	8	22
601	T.CD4_Tcm.effector_like	1.51e-04	Nonsignificant	0.88	0.98	Other	293	533
602	NK.adaptive_axis_baseline	1.40e-04	Nonsignificant	0.70	1.02	Other	1,008	153
603	T.MAIT.vesicle	1.37e-04	Nonsignificant	0.95	0.73	Other	37	65
604	B.germinal_center.DZ_M_phase	1.25e-04	Nonsignificant	—	1.47	Other	0	0
605	T.CD4_naive.survival_mitoprot	1.20e-04	Nonsignificant	0.86	1.06	Other	13	7
606	T.MAIT.cytotoxic	1.18e-04	Nonsignificant	0.95	0.77	Other	52	15
607	T.CD4_naive.survival_neddylation	1.17e-04	Nonsignificant	0.86	1.08	Other	26	38
608	T.MAIT.quiescent	9.55e-05	Nonsignificant	0.95	0.66	Other	100	5
609	T.CD8_naive.baseline	9.50e-05	Nonsignificant	0.88	0.96	Other	142	2
610	NK.cytokine_quiescent	9.40e-05	Nonsignificant	0.89	1.01	Other	623	1,062
611	CM.osmoprotection	9.03e-05	Nonsignificant	1.00	0.97	Other	34	57
612	T.MAIT.stress	8.91e-05	Nonsignificant	—	0.00	Other	0	0
613	NK.cytokine_axis_baseline	8.72e-05	Nonsignificant	1.00	0.99	Other	1,172	116
614	T.CD8_Tcm.helper_like	8.58e-05	Nonsignificant	0.76	1.01	Other	81	159
615	T.CD4_Tcm.retro_ZNF117	8.52e-05	Nonsignificant	0.74	1.13	Other	5	9
616	T.CD8_Tem.early_helper_like	8.12e-05	Nonsignificant	0.88	1.02	Other	445	755
617	T.CD4_Treg.APC_interactive	7.68e-05	Nonsignificant	0.61	0.99	Other	118	28
618	T.gamma_delta.central_memory	7.58e-05	Nonsignificant	0.79	1.01	Other	460	919
619	T.CD4_naive.resist_bystander	7.57e-05	Nonsignificant	0.86	1.02	Other	40	25
620	NK.cytokine_biosynthetic_primed	7.16e-05	Nonsignificant	0.89	1.03	Other	360	21
621	T.gamma_delta.early_effector	6.65e-05	Nonsignificant	0.85	0.96	Other	89	0
622	T.CD8_naive.splicing_enriched	6.33e-05	Nonsignificant	0.82	0.99	Other	120	16
623	T.CD4_naive.neddylation_mitoprot	5.72e-05	Nonsignificant	0.94	0.96	Other	93	56
624	T.CD8_transitional.APC_like	5.67e-05	Nonsignificant	0.89	0.96	Other	205	62
625	EPI.salivary_intercalated_defense.basal_EMT	5.33e-05	Nonsignificant	—	0.00	Other	0	0
626	EPI.salivary_myoepithelial.activated	4.67e-05	Nonsignificant	0.95	0.67	Other	85	281
627	T.CD4_Tcm.Th2_like	4.13e-05	Nonsignificant	0.88	1.00	Other	23	55
628	T.CD4_Tcm.secretory	3.95e-05	Nonsignificant	0.85	1.03	Other	20	11
629	CM.sarcomere_actin_interface	3.91e-05	Nonsignificant	1.00	0.91	Other	450	78
630	T.CD4_naive.survival	3.51e-05	Nonsignificant	0.86	1.05	Other	12	17
631	T.CD4_Treg.central_naive_like	3.47e-05	Nonsignificant	0.03	1.21	Other	333	45
632	ILC2.migratory	3.41e-05	Nonsignificant	—	0.00	Other	0	0
633	NK.cytokine_tissue_resident	3.36e-05	Nonsignificant	0.91	1.06	Other	74	82
634	T.CD8_Tcm.effector_bias	3.27e-05	Nonsignificant	0.76	1.11	Other	199	329
635	CM.inflammatory	3.12e-05	Nonsignificant	—	1.12	Other	0	0
636	EPI.pancreatic_acinar.metabolic_onecarbon	3.10e-05	Nonsignificant	0.86	0.94	Other	287	328
637	T.CD4_naive.proteostasis_mitoprot	2.87e-05	Nonsignificant	0.94	0.93	Other	15	37
638	FIB.adventitial.baseline	2.71e-05	Nonsignificant	1.00	0.77	Other	157	278
639	CM.translation_boost_RPL	2.69e-05	Nonsignificant	1.00	0.93	Other	129	1
640	CM.translation_boost_RPS	2.46e-05	Nonsignificant	1.00	0.96	Other	69	16
641	T.CD4_Tcm.APC_mimicry	2.22e-05	Nonsignificant	0.88	0.97	Other	54	43
642	FIB.adventitial.mechano_chemo_sensing	2.11e-05	Nonsignificant	1.00	0.80	Other	135	524
643	T.CD8_Tem.TEMRA	2.06e-05	Nonsignificant	0.98	0.98	Other	920	1,088
644	CHOND.angiogenic	2.04e-05	Nonsignificant	—	0.00	Other	0	0
645	CM.mito_proteostasis	1.61e-05	Nonsignificant	1.00	0.92	Other	329	29
646	T.CD4_Tcm.Tfh_like	1.50e-05	Nonsignificant	0.89	0.93	Other	102	214
647	T.CD4_cytotoxic.terminal_effector	1.35e-05	Nonsignificant	0.55	1.08	Other	286	21
648	EPI.pancreatic_acinar.quiet_dedifferentiation	1.29e-05	Nonsignificant	0.69	1.09	Other	142	171
649	THYMO.CD8aa_IELp	1.20e-05	Nonsignificant	—	0.00	Other	1	7
650	T.CD8_naive.mito_proteostasis	1.09e-05	Nonsignificant	0.82	1.02	Other	428	100
651	CM.mechano_activated	1.08e-05	Nonsignificant	1.00	0.98	Other	205	134
652	T.CD4_Tcm.synapse_dynamics	1.02e-05	Nonsignificant	0.85	1.03	Other	15	10
653	EPI.pancreatic_acinar.adhesion_remodeling	9.31e-06	Nonsignificant	0.86	0.90	Other	210	784
654	T.CD4_Tcm.RNA_control	7.61e-06	Nonsignificant	0.89	0.89	Other	96	4
655	T.CD8_Tcm.baseline	7.57e-06	Nonsignificant	0.76	0.97	Other	90	89
656	T.CD4_Tem.cytotoxic_effector	7.29e-06	Nonsignificant	0.94	0.80	Other	225	398
657	T.CD4_Tcm.regulatory_poised	6.30e-06	Nonsignificant	0.89	0.91	Other	2	3
658	B.germinal_center.LZ_selection	4.79e-06	Nonsignificant	—	0.58	Other	0	0
659	NK.adaptive_immature_precursor	4.75e-06	Nonsignificant	1.00	0.98	Other	358	111
660	T.CD4_cytotoxic.precursor	4.25e-06	Nonsignificant	0.55	1.19	Other	156	67
661	T.CD8_Tcm.NK_like	3.69e-06	Nonsignificant	0.76	0.85	Other	334	581
662	NK.cytokine_vascular_patrolling	3.26e-06	Nonsignificant	1.00	0.93	Other	863	94
663	T.CD4_naive.purinergic	2.89e-06	Nonsignificant	0.94	0.86	Other	49	1
664	T.CD4_naive.gut_prone	2.80e-06	Nonsignificant	0.94	0.90	Other	35	70
665	ADIPO.immature	2.79e-06	Nonsignificant	—	0.21	Other	24	40
666	T.CD8_naive.innate_like	2.55e-06	Nonsignificant	0.82	0.91	Other	10	1
667	T.CD4_Tcm.crosstalk_myeloid	2.46e-06	Nonsignificant	0.89	0.86	Other	5	4
668	EPI.pancreatic_acinar.baseline	2.06e-06	Nonsignificant	0.93	0.76	Other	274	163
669	B.germinal_center.DZ_S_phase	1.66e-06	Nonsignificant	—	0.00	Other	0	0
670	ADIPO.thermogenic	1.36e-06	Nonsignificant	—	0.34	Other	0	0
671	ADIPO.hypoxia_remodelling	8.20e-07	Nonsignificant	—	0.00	Other	29	105
672	T.CD4_Treg.Tr1_like	6.63e-07	Nonsignificant	—	0.00	Other	8	8
673	CM.anti_inflammatory	3.86e-07	Nonsignificant	1.00	0.74	Other	424	1,503
674	NK.adaptive_adipose_stress	3.86e-07	Nonsignificant	1.00	0.89	Other	374	39
675	T.CD8_Tem.stress_adapted	2.99e-07	Nonsignificant	0.98	0.90	Other	607	520
676	B.germinal_center.LZ_memory_precursor	2.61e-07	Nonsignificant	—	0.00	Other	0	0
677	T.CD4_cytotoxic.NK_adapted	2.44e-07	Nonsignificant	0.79	1.07	Other	82	33
678	ADIPO.inflammatory	1.87e-07	Nonsignificant	—	0.00	Other	0	0
679	FIB.adventitial.mito_secretory	1.71e-07	Nonsignificant	1.00	0.47	Other	21	7
680	T.CD4_naive.activated_stress	1.70e-07	Nonsignificant	0.95	0.63	Other	339	429
681	ASPC.signal_integrator	1.45e-07	Nonsignificant	—	0.00	Other	0	0
682	B.germinal_center.LZ_survival	9.58e-08	Nonsignificant	—	0.00	Other	0	0
683	NK.cytokine_tissue_activation	9.08e-08	Nonsignificant	1.00	0.92	Other	267	450
684	T.CD4_cytotoxic.baseline	6.45e-08	Nonsignificant	0.79	0.95	Other	0	0
685	T.CD8_Tem.motility_primed	5.28e-08	Nonsignificant	0.98	0.91	Other	269	4
686	NK.adaptive_terminal_cytotoxic	1.95e-08	Nonsignificant	1.00	0.71	Other	485	802
687	T.CD4_cytotoxic.activated	6.78e-09	Nonsignificant	0.90	0.74	Other	3	1
688	NK.adaptive_biosynthetic_primed	6.42e-10	Nonsignificant	1.00	0.52	Other	244	405

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

290 unique genes. Showing 1–290. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
APOC2	01-High	0.75	22.12	G1	C1	MAC.MDM.LAM_like (L2)	macrophage (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) HEP.periportal_metabolic.xenobiotic_detox (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EPI.renal_proximal_tubule.onecarbon_peroxisome (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	93 cells — complete matches	203	1,252
PLAUR	01-High	0.71	17.94	G1	C1	DC.cDC1.activated (L2), DC.cDC2.pro_inflammatory (L2), EPI.esophageal_basal.junctional_barrier (L2), FIB.adventitial.inflammatory_activated (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) GRANU.neutrophil (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant) GRANU.neutrophil.tissue_patrolling (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	112 cells — complete matches	34	60
APOC1	01-High	0.70	21.08	G1	C1	ASPC.adipocyte_capillary_interface (L2), ASPC.remodeling (L2), DC.cDC2.lipid_metabolic (L2), EPI.ectocervical_granular.secretory_apocrine (L2), FIB.reticular.stromal_niche (L2), MAC.MDM.LAM_like (L2), MONO.CD16.hepatic_mac_like (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	135 cells — complete matches	301	1,434
VASP	01-High	0.69	14.43	G1	C1	EPI.thymic_cortical.Notch_interface (L2)	—	T.CD4_Tem.transitional_CM (L2)	27	117
GRN	01-High	0.68	10.59	G1	C1	PERI.cardiac_skeletal (L2)	DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	31 cells — complete matches	12	23
MIR8085	01-High	0.67	16.04	G1	C1	—	—	—	26	71
RN7SL368P	01-High	0.67	16.05	G1	C1	—	—	—	31	56
CEACAM16-AS1	01-High	0.66	23.63	G1	C1	—	—	—	100	849
CADM4	01-High	0.66	17.17	G1	C1	—	dendritic_cell (Tier: relevant)	24 cells — complete matches	30	54
ENSG00000308028	01-High	0.65	16.57	G1	C1	—	—	—	32	57
BCL3	01-High	0.64	13.30	G1	C1	EC.arterial.inflammatory (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), HEP.pericentral_lipoprotein.UPR_redox (L2), MUSC.early_activation (L2), T.CD4_Tcm.regulatory_poised (L2)	—	14 cells — complete matches	73	301
CLPTM1	01-High	0.64	20.90	G1	C1	—	—	T.CD4_naive.activated_stress (L2)	254	1,362
SRRM5	01-High	0.64	17.04	G1	C1	T.CD8_naive.splicing_enriched (L2)	—	6 cells — complete matches	30	54
ZNF576	01-High	0.64	17.04	G1	C1	T.CD8_naive.splicing_enriched (L2)	—	6 cells — complete matches	30	54
LYPD3	01-High	0.63	19.76	G1	C1	EPI.esophageal_suprabasal.differentiating_keratin (L2)	monocyte (Tier: specific) DC.cDC2 (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.MDM.complement_resolving (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	106 cells — complete matches	35	60
MS4A6A	01-High	0.62	13.48	G1	C1	MONO.CD16.hepatic_mac_like (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) EC.liver_sinusoidal.stress (Tier: specific) MAC.resident_cardiac.inflammatory_reparative (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_cardiac (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EC.liver_sinusoidal.inflammatory (Tier: relevant) EC.liver_sinusoidal.secretory_lipoprotein (Tier: relevant) EPI.ectocervical_granular.immune_interact (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	91 cells — complete matches	38	78
ZNF575	01-High	0.62	15.32	G1	C1	—	MAC.resident_repair (Tier: relevant)	33 cells — complete matches	30	54
ETHE1	01-High	0.62	16.28	G1	C1	—	—	5 cells — complete matches	35	61
SMG9	01-High	0.62	17.60	G1	C1	—	—	7 cells — complete matches	30	54
XRCC1	01-High	0.62	15.86	G1	C1	—	—	EC.capillary.migratory (L2), FIB.perivascular_interface.vascular_BM_remodelling (L2), T.CD4_cytotoxic.activated (L2)	30	54
AP2S1	01-High	0.62	8.09	G1	C1	—	MAC.resident_iron (Tier: relevant)	MAC.resident_iron (L1S), B.naive.baseline (L2), MAC.resident_iron.redox_metabolic (L2)	25	37
PTK2B	01-High	0.61	6.59	G1	C1	—	—	17 cells — complete matches	26	72
IGSF23	01-High	0.61	15.48	G1	C1	—	HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.periportal_metabolic.xenobiotic_detox (Tier: specific)	10 cells — complete matches	77	688
ENSG00000269177	01-High	0.61	14.68	G1	C1	—	—	—	30	52
IRGQ	01-High	0.61	13.45	G1	C1	—	DC.cDC2 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.microglia_like (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant)	18 cells — complete matches	30	55
PINLYP	01-High	0.60	15.42	G1	C1	—	—	13 cells — complete matches	30	52
KCNN4	01-High	0.60	16.51	G1	C1	MAC.alveolar.capillary_interacting (L2), PERI.angiocrine (L2)	monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MONO.CD14 (Tier: specific) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	75 cells — complete matches	27	66
ZNF428	01-High	0.60	11.98	G1	C1	—	—	—	30	54
BCAM	01-High	0.59	24.28	G1	C1	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), NEU.EXC_IT.neuromodulated (L2)	EPI.renal_distal_tubule.ion_transport (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant)	82 cells — complete matches	119	896
ENSG00000269583	01-High	0.59	14.46	G1	C1	—	—	—	30	52
TOMM40	01-High	0.58	17.42	G1	C1	—	—	DC.cDC2.monocyte_like (L2), EPI.ileal_goblet.immature (L2)	296	1,418
ENSG00000290609	01-High	0.58	12.10	G1	C1	—	—	—	30	54
NECTIN2	01-High	0.58	20.99	G1	C1	—	MONO.CD14.APC_like (Tier: specific)	17 cells — complete matches	217	1,214
CEACAM19	01-High	0.58	18.01	G1	C1	—	MAC.LAM (Tier: specific) MONO.CD14.APC_like (Tier: specific)	22 cells — complete matches	81	710
ENSG00000279095	01-High	0.58	19.58	G1	C1	—	—	—	77	701
MS4A4A	01-High	0.58	15.06	G1	C1	MAC.MDM.complement_resolving (L2), MAC.resident_repair.chemokine_angiocrine (L2), MONO.CD14.repair_M2_like (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_cardiac.inflammatory_reparative (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_cardiac (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	76 cells — complete matches	41	76
ENSG00000307907	01-High	0.57	7.50	G1	C1	—	—	—	489	1,000
SLC8B1	01-High	0.57	8.76	G1	C1	MAC.resident_repair.stress_iron (L2)	MAC.resident_repair.lipid_phagocytic (Tier: specific) MAC.resident_repair (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	24 cells — complete matches	9	12
TPCN1	01-High	0.57	8.42	G1	C1	—	MONO.CD14 (Tier: specific) MAC.resident_cardiac (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	16 cells — complete matches	7	11
ENSG00000268601	01-High	0.56	13.08	G1	C1	—	—	—	27	50
HLA-DRB1	01-High	0.56	8.27	G1	C1	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), FIB.reticular.immune_interface (L2), MAC.resident_cardiac.antigen_presenting (L2), MAC.resident_repair.antigen_presenting (L2), MG.phagocytic_APC (L2), MONO.CD14.APC_like (L2), NK.adaptive_axis_baseline (L2), NK.adaptive_biosynthetic_primed (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Tfh.effector_migratory (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EPI.cervical_suprabasal.secretory_vesicle (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	203 cells — complete matches	565	1,192
RTN2	01-High	0.56	20.47	G1	C1	—	—	19 cells — complete matches	21	92
ENSG00000300917	01-High	0.56	13.02	G1	C1	—	—	—	28	50
ENSG00000296816	01-High	0.56	14.31	G1	C1	—	—	—	15	28
ZNF283	01-High	0.55	13.97	G1	C1	—	MONO.CD16.platelet_bound (Tier: relevant)	17 cells — complete matches	26	51
TRIM35	01-High	0.55	5.49	G1	C1	—	—	19 cells — complete matches	16	39
MS4A2	01-High	0.55	14.42	G1	C1	GRANU.MAST (L1S)	—	10 cells — complete matches	34	66
EML2	01-High	0.55	21.11	G1	C1	—	—	4 cells — complete matches	25	94
ENSG00000307923	01-High	0.54	4.61	G1	C1	—	—	—	371	796
DDX54	01-High	0.54	8.21	G1	C1	—	—	T.CD4_Th2 (L1S), T.CD4_Th2.tissue_adapted (L2), T.CD4_transitional.tissue_enagement (L2)	8	14
MS4A4E	01-High	0.54	13.89	G1	C1	MAC.kupffer.tolerogenic (L2)	macrophage (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD16 (Tier: specific) EC.liver_sinusoidal.stress (Tier: specific) MAC.resident_cardiac.inflammatory_reparative (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.resident_cardiac (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EC.liver_sinusoidal.inflammatory (Tier: relevant) EC.liver_sinusoidal.secretory_lipoprotein (Tier: relevant) MAC.kupffer.fibrogenic (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant)	66 cells — complete matches	63	119
EML2-AS1	01-High	0.54	20.59	G1	C1	—	—	—	21	92
CEACAM16	01-High	0.54	14.86	G1	C1	—	—	—	54	258
CEACAM22P.2	01-High	0.54	18.49	G1	C1	—	—	—	77	699
ZNF224	01-High	0.54	12.56	G1	C1	—	—	15 cells — complete matches	25	48
LYPD5	01-High	0.54	11.66	G1	C1	—	—	20 cells — complete matches	22	43
CFAP73	01-High	0.54	7.30	G1	C1	EPI.lung_club_secretory.ciliogenesis_axoneme (L2), EPI.lung_multiciliated.baseline (L2)	DC.cDC2.proliferative (Tier: relevant)	20 cells — complete matches	7	11
FOSB	01-High	0.53	12.34	G1	C1	ASPC.activated (L2), B.naive.activated (L2), EC.heart_remodeling.activated_acute (L2), EPI.colonocyte.crypt_progenitor (L2), EPI.pancreatic_ductal_bicarbonate.activated (L2), EPI.salivary_myoepithelial.activated (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), FIB.reticular.stromal_niche (L2), GRNLSA.EMT_insulin_signaling (L2), HEP.periportal_metabolic.stress_chaperone (L2), MEL.dedifferentiated_migratory (L2), MESO.activated_stress (L2), PC.IgG_systemic.interacting (L2), SMC.activated (L2), T.CD4_Tfh.precursor_migratory (L2), T.CD4_Trm.activated (L2)	EPI.renal_distal_tubule.stress (Tier: relevant)	74 cells — complete matches	10	20
ENSG00000299344	01-High	0.53	12.57	G1	C1	—	—	—	7	19
ENSG00000309733	01-High	0.52	7.50	G1	C1	—	—	—	468	929
CBLC	01-High	0.52	16.85	G1	C1	—	—	5 cells — complete matches	64	316
ENSG00000291145	01-High	0.52	14.01	G1	C1	—	—	—	10	28
PPM1N	01-High	0.52	15.57	G1	C1	EPI.thymic_cortical.Notch_interface (L2), MONO.CD16.patrolling (L2)	DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	41 cells — complete matches	23	103
MS4A3	01-High	0.52	11.32	G1	C1	—	—	9 cells — complete matches	33	65
RASAL1	01-High	0.52	7.53	G1	C1	—	DC.cDC2 (Tier: specific) dendritic_cell (Tier: relevant) DC.cDC2.proliferative (Tier: relevant)	31 cells — complete matches	11	15
MIR330	01-High	0.52	18.77	G1	C1	—	—	—	23	93
ENSG00000303542	01-High	0.52	7.65	G1	C1	—	—	—	7	8
ENSG00000285128	01-High	0.51	17.90	G1	C1	—	—	—	86	636
ERCC1	01-High	0.51	14.71	G1	C1	—	MAC.microglia_like.inflammatory_chemokine (Tier: relevant)	EPI.ectocervical_granular.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2)	7	10
HLA-DQA1	01-High	0.50	7.43	G1	C1	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), MAC.resident_iron.APC_iron_sensing (L2), MONO.CD14.APC_like (L2), MONO.CD16.hepatic_mac_like (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MG.phagocytic_APC (Tier: relevant)	159 cells — complete matches	608	1,232
OOSP4B	01-High	0.50	10.83	G1	C1	—	—	—	28	59
PLBD2	01-High	0.50	8.25	G1	C1	—	MONO.CD14.APC_like (Tier: specific)	14 cells — complete matches	9	12
GBA1	01-High	0.50	0.78	G1	C1	—	—	—	31	52
IQCD	01-High	0.50	7.39	G1	C1	—	EPI.cervical_suprabasal.secretory_vesicle (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant)	11 cells — complete matches	7	11
SDSL	01-High	0.49	8.47	G1	C1	—	MAC.LAM (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.resident_iron (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	37 cells — complete matches	7	11
PVR	01-High	0.49	12.83	G1	C1	—	DC.cDC2 (Tier: specific) dendritic_cell (Tier: relevant) DC.cDC2.proliferative (Tier: relevant)	26 cells — complete matches	79	711
OPA3	01-High	0.49	15.25	G1	C1	—	—	7 cells — complete matches	23	96
ENSG00000214788	01-High	0.49	11.06	G1	C1	—	—	—	27	63
ENSG00000298585	01-High	0.49	9.30	G1	C1	—	—	—	20	92
DTX1	01-High	0.49	7.02	G1	C1	—	—	44 cells — complete matches	11	24
C9orf72	01-High	0.48	6.16	G1	C1	EPI.ectocervical_granular.secretory_apocrine (L2)	monocyte (Tier: specific) GRANU.neutrophil (Tier: specific) MONO.CD14 (Tier: specific) MAC.resident_repair (Tier: relevant) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant) GRANU.neutrophil.tissue_patrolling (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	18 cells — complete matches	3	8
APOC4-APOC2	01-High	0.48	21.05	G1	C1	—	HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.periportal_metabolic.xenobiotic_detox (Tier: specific)	10 cells — complete matches	211	1,246
SDS	01-High	0.47	6.60	G1	C1	MAC.LAM.antimicrobial (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	70 cells — complete matches	7	11
RITA1	01-High	0.47	7.24	G1	C1	—	—	12 cells — complete matches	8	13
APOC4	01-High	0.47	20.71	G1	C1	—	HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.periportal_metabolic.xenobiotic_detox (Tier: specific)	10 cells — complete matches	242	1,341
ENSG00000288863	01-High	0.47	6.94	G1	C1	—	—	—	8	12
ENSG00000295497	01-High	0.47	6.01	G1	C1	—	—	—	7	9
ENSG00000299359	01-High	0.46	11.37	G1	C1	—	—	—	5	7
GIPR	01-High	0.46	13.53	G1	C1	—	MAC.resident_repair.lipid_phagocytic (Tier: specific)	33 cells — complete matches	20	95
ENSG00000302518	01-High	0.46	14.43	G1	C1	—	—	—	121	890
ENSG00000257286	01-High	0.46	7.19	G1	C1	—	—	—	8	8
MS4A6E	01-High	0.45	8.53	G1	C1	—	macrophage (Tier: specific) MAC.LAM (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.proliferating (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	18 cells — complete matches	77	122
TCN1	01-High	0.45	6.83	G1	C1	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro (L2), EPI.tracheal_submucosal_gland.acinar_serous (L2)	—	32 cells — complete matches	34	66
OOSP1	01-High	0.45	6.96	G1	C1	—	—	—	9	23
ENSG00000304183	01-High	0.44	9.30	G1	C1	—	—	—	20	91
OAS2	01-High	0.43	6.16	G1	C1	MESO.antiviral (L2)	—	32 cells — complete matches	8	25
MS4A13	01-High	0.42	4.92	G1	C1	—	—	—	95	152
LHX5	01-High	0.42	5.68	G1	C1	IPSC.midbrain_primed (L2)	IPSC.midbrain_primed (Tier: relevant)	IPSC.midbrain_primed (L2), IPSC.neuroendocrine_primed (L2)	1	2
OAS1	01-High	0.42	5.59	G1	C1	ADIPO.thermogenic (L2)	MONO.CD16 (Tier: specific) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant)	28 cells — complete matches	8	23
APOE	01-High	0.41	13.16	G1	C1	macrophage (L1), HEP.pericentral_lipoprotein (L1S), MAC.LAM (L1S), MAC.microglia_like (L1S), ASPC.adipocyte_capillary_interface (L2), EPI.ectocervical_granular.secretory_apocrine (L2), EPI.renal_intercalated_cell_type_A.acid_secretion (L2), EPI.skin_appendage_keratinocyte.sebaceous_apocrine (L2), EPI.skin_hair_follicle_bulge.niche_crosstalk (L2), EPI.skin_keratinocyte_progenitor.quiescent_stem_like (L2), EPI.skin_keratinocyte_proliferating.early_spinous_transition (L2), FIB.interstitial.lipid_matrix (L2), FIB.perivascular_interface.lipid_shuttle (L2), FIB.suburothelial.homeostasis_matrix (L2), FIB.transitioning.ISG_primed_interface (L2), HEP.acute_phase.stress_secretory (L2), HEP.periportal_metabolic.apolipoprotein_secretory (L2), MAC.LAM.inflammatory_APC (L2), MAC.MDM.LAM_like (L2), MAC.resident_repair.lipid_phagocytic (L2), MG.phagocytic_APC (L2), NEU.INH_LAMP5.glial_interface (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) EPI.renal_proximal_tubule (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	163 cells — complete matches	351	1,543
OAS3	01-High	0.41	5.13	G1	C1	MESO.antiviral (L2)	GRANU.neutrophil.tissue_patrolling (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	36 cells — complete matches	11	38
OOSP3	01-High	0.41	5.09	G1	C1	—	—	—	20	47
MS4A14	01-High	0.40	5.35	G1	C1	—	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_cardiac.inflammatory_reparative (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.resident_cardiac (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.kupffer.fibrogenic (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	91 cells — complete matches	79	127
ENSG00000267282	01-High	0.39	9.30	G1	C1	—	—	—	213	1,188
RPH3A	01-High	0.38	2.86	G1	C1	—	NEU.EXC_CT.Ca2_sensor (Tier: relevant)	21 cells — complete matches	9	26
CBLIF	01-High	0.38	2.83	G1	C1	—	—	—	32	63
ENSG00000257359	01-High	0.32	1.88	G1	C1	—	—	—	0	2
ENSG00000280087	02-Medium	0.61	12.67	G1	C2	—	—	—	359	1,576
MARK4	02-Medium	0.59	26.88	G2	C1	—	—	B.age_associated.migratory (L2), T.CD4_naive.survival_neddylation (L2), T.CD8_Tem.signaling_turnover (L2)	21	73
APOC1P1	02-Medium	0.59	9.30	G1	C2	—	—	—	317	1,464
APOC1P1.2	02-Medium	0.59	9.30	G1	C2	—	—	—	317	1,464
EXOC3L2	02-Medium	0.58	18.91	G1	C2	—	EC.liver_sinusoidal.stress (Tier: specific) platelet (Tier: relevant) PLAT.platelet (Tier: relevant) EC.liver_sinusoidal.secretory_lipoprotein (Tier: relevant) PLAT.adhesion (Tier: relevant)	35 cells — complete matches	19	73
ENSG00000289428	02-Medium	0.58	21.95	G1	C2	—	—	—	0	0
KLC3	02-Medium	0.56	17.28	G1	C2	—	—	58 cells — complete matches	6	42
CLASRP	02-Medium	0.55	14.56	G2	C1	—	—	B.naive.baseline (L2), B.naive.proteostasis (L2)	15	15
ZNF234	02-Medium	0.54	17.34	G1	C2	—	—	12 cells — complete matches	0	0
ACE	02-Medium	0.54	9.30	G1	C2	—	MAC.LAM (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific)	47 cells — complete matches	11	44
ZNF229	02-Medium	0.53	21.34	G2	C2	—	—	5 cells — complete matches	0	0
CLU	02-Medium	0.53	8.56	G1	C2	EC.arterial.elastic (L2), EC.capillary.postcap_venule (L2), EC.heart_remodeling.remodeling_stalk (L2), EC.venous.baseline (L2), EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_acinar.stress (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), EPI.renal_immature_ureteric_bud.defense_secretory (L2), EPI.renal_principal_cell.injury_repair (L2), EPI.salivary_myoepithelial.baseline (L2), EPI.skin_hair_follicle_bulge.quiescent (L2), EPI.tracheal_submucosal_gland.ductal_luminal (L2), FIB.interstitial.remodeling (L2), FIB.reticular.immune_interface (L2), MEL.secretory_quiescent (L2), MESO.secretory_structural (L2), NEU.EXC_NTNG1.synaptic (L2), T.CD4_Tcm.tissue_homing (L2), T.CD4_Tem.inflammatory (L2)	monocyte (Tier: specific) GRANU.neutrophil (Tier: specific) MONO.CD14 (Tier: specific) platelet (Tier: relevant) PLAT.platelet (Tier: relevant) EPI.renal_distal_tubule.stress (Tier: relevant) EPI.renal_principal_cell.activated_acute (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant) IPSC.midbrain_primed (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant) PLAT.adhesion (Tier: relevant)	154 cells — complete matches	11	28
PPP1R13L	02-Medium	0.53	16.95	G2	C2	—	—	15 cells — complete matches	2	1
ENSG00000267188	02-Medium	0.52	20.51	G2	C2	—	—	—	0	0
MIR6843	02-Medium	0.52	7.29	G1	C2	—	—	—	11	22
BIN1	02-Medium	0.51	6.96	G1	C2	—	DC.cDC2 (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) EPI.cervical_suprabasal.secretory_vesicle (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant)	41 cells — complete matches	9	15
GEMIN7-AS1	02-Medium	0.51	17.52	G1	C2	—	—	—	1	2
RELB	02-Medium	0.51	17.46	G1	C2	DC.mig.baseline (L2), EPI.colonocyte.junction_remodeling (L2), EPI.pancreatic_ductal_bicarbonate.inflammatory (L2), FIB.suburothelial.inflammatory_prostanoid (L2), GRNLSA.lipid_hypoxia (L2)	EPI.renal_distal_tubule.stress (Tier: relevant)	23 cells — complete matches	41	86
PHLDB3	02-Medium	0.51	13.55	G1	C2	—	—	41 cells — complete matches	17	31
IRF2BP1	02-Medium	0.50	11.22	G1	C2	—	—	17 cells — complete matches	80	281
ENSG00000264813	02-Medium	0.50	5.50	G1	C2	—	—	—	7	31
CKM	02-Medium	0.49	13.18	G1	C2	skeletal_muscle_cell (L1), SKM.type_1_slow (L1S), SKM.type_2_fast (L1S), CM.contractile_oxphos (L2)	MAC.resident_cardiac.inflammatory_reparative (Tier: specific) MAC.resident_cardiac (Tier: relevant) MAC.resident_repair (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant)	28 cells — complete matches	7	11
PPP1R37	02-Medium	0.49	11.31	G1	C2	—	—	14 cells — complete matches	4	4
ENSG00000294899	02-Medium	0.49	9.32	G1	C2	—	—	—	2	1
HAVCR2	02-Medium	0.48	4.84	G2	C1	—	MAC.kupffer.inflammatory (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant)	14 cells — complete matches	23	87
BLOC1S3	02-Medium	0.48	16.38	G2	C2	—	—	22 cells — complete matches	3	5
ENSG00000300853	02-Medium	0.48	8.81	G1	C2	—	—	—	10	24
CCDC61	02-Medium	0.47	20.89	G2	C2	—	—	11 cells — complete matches	5	28
SCARA3	02-Medium	0.47	7.86	G1	C2	—	—	40 cells — complete matches	16	40
NKPD1	02-Medium	0.47	9.30	G1	C2	—	—	4 cells — complete matches	4	4
ENSG00000303467	02-Medium	0.47	16.88	G2	C2	—	—	—	3	10
TRAPPC6A	02-Medium	0.46	12.62	G2	C2	—	—	5 cells — complete matches	3	5
GEMIN7	02-Medium	0.46	12.89	G2	C1	—	—	5 cells — complete matches	3	3
ZNF296	02-Medium	0.46	12.53	G2	C1	—	DC.cDC2 (Tier: specific) dendritic_cell (Tier: relevant) IPSC.stress (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	55 cells — complete matches	2	3
ENSG00000286400	02-Medium	0.46	8.05	G1	C2	—	—	—	1	0
MICB	02-Medium	0.46	6.77	G1	C2	—	MAC.proliferating (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant)	43 cells — complete matches	294	633
HLA-DRB5	02-Medium	0.46	8.79	G2	C1	EC.venous.baseline (L2), EPI.endocervical_secretory.secretory_translocon (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MG.phagocytic_APC (L2), NK.adaptive_classII_inhibitory (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	macrophage (Tier: specific) monocyte (Tier: specific) DC.cDC2 (Tier: specific) MAC.alveolar (Tier: specific) MAC.LAM (Tier: specific) MAC.MDM (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.proliferating (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	193 cells — complete matches	364	756
POLR1G	02-Medium	0.45	9.30	G2	C2	—	—	—	0	0
ENSG00000267114	02-Medium	0.45	9.30	G1	C2	—	—	—	160	1,070
EPHX2	02-Medium	0.45	7.85	G1	C2	EPI.colonocyte.proximal_transport (L2)	—	45 cells — complete matches	12	27
CHRNA2	02-Medium	0.44	7.65	G1	C2	NEU.INH_PVALB.neuromodulatory (L2)	—	8 cells — complete matches	10	27
ZNF225-AS1	02-Medium	0.44	14.96	G2	C2	—	—	—	0	0
ERCC2	02-Medium	0.44	14.35	G2	C2	—	—	10 cells — complete matches	5	39
MICB-DT	02-Medium	0.44	6.75	G1	C2	—	—	—	131	286
ENSG00000301764	02-Medium	0.43	6.26	G1	C2	—	—	—	4	7
CCDC25	02-Medium	0.43	6.24	G1	C2	—	MAC.LAM.anti_inflammatory (Tier: relevant)	EC.venous.quiescent_homeostatic (L2), MAC.LAM.anti_inflammatory (L2), MAC.kupffer.tolerogenic (L2)	11	22
ENSG00000253875	02-Medium	0.43	5.43	G1	C2	—	—	—	4	7
MIR6797	02-Medium	0.42	1.39	G2	C2	—	—	—	2	2
MOB3B	02-Medium	0.42	5.63	G2	C1	HEP.canalicular_transport.ductular_like_transition (L2)	—	36 cells — complete matches	3	6
CUX1	02-Medium	0.42	4.85	G1	C2	NEU.EXC_IT (L1S)	—	DC.cDC2.antiviral (L2)	16	19
HIF3A	02-Medium	0.42	11.07	G2	C2	EC.arterial.arteriole_gas_exchange (L2), EC.venous.cardiac_structural (L2)	—	47 cells — complete matches	12	50
QPCTL	02-Medium	0.42	12.11	G2	C2	—	MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	23 cells — complete matches	14	53
ZNF225	02-Medium	0.41	11.57	G2	C2	—	—	26 cells — complete matches	0	0
EMICERI	02-Medium	0.41	6.34	G2	C1	—	—	—	3	6
SH2B2	02-Medium	0.41	4.95	G1	C2	—	GRANU.neutrophil (Tier: specific) MONO.CD16 (Tier: specific) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	45 cells — complete matches	4	7
ENSG00000295429	02-Medium	0.41	8.70	G1	C2	—	—	—	7	31
ENSG00000294696	02-Medium	0.41	11.46	G2	C2	—	—	—	75	265
ENSG00000304559	02-Medium	0.40	2.60	G2	C1	—	—	—	337	717
ENSG00000288773	02-Medium	0.40	14.55	G1	C2	—	—	—	81	522
CYB561	02-Medium	0.40	8.26	G1	C2	—	—	51 cells — complete matches	14	41
GPR4	02-Medium	0.40	14.31	G2	C2	—	EC.liver_sinusoidal.secretory_lipoprotein (Tier: relevant)	34 cells — complete matches	9	45
KCNH6	02-Medium	0.40	5.68	G1	C2	EPI.pancreatic_islet.alpha (L2)	—	13 cells — complete matches	13	39
ENSG00000309717	02-Medium	0.40	9.19	G1	C2	—	—	—	75	265
FERMT2	02-Medium	0.40	6.88	G1	C2	—	—	13 cells — complete matches	11	62
CD177	02-Medium	0.40	10.76	G2	C2	—	GRANU.neutrophil (Tier: specific) EPI.cervical_suprabasal.secretory_vesicle (Tier: relevant) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant)	17 cells — complete matches	2	3
ENSG00000265282	02-Medium	0.40	7.36	G1	C2	—	—	—	11	39
SLC50A1	02-Medium	0.39	1.37	G1	C2	—	MAC.microglia_like.inflammatory_chemokine (Tier: relevant)	7 cells — complete matches	3	4
ESCO2	02-Medium	0.39	4.04	G1	C2	—	DC.cDC2 (Tier: specific) dendritic_cell (Tier: relevant) MAC.proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant)	42 cells — complete matches	5	8
IFNK	02-Medium	0.39	5.72	G2	C1	—	MONO.CD14.APC_like (Tier: specific)	MONO.CD14.APC_like (L2)	2	5
SCARA5	02-Medium	0.39	3.24	G1	C2	FIB.adventitial.PI16_matrix (L2)	—	34 cells — complete matches	17	28
ENSG00000287355	02-Medium	0.38	6.14	G2	C1	—	—	—	3	6
PBK	02-Medium	0.38	3.34	G1	C2	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M (L2)	MAC.proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant)	42 cells — complete matches	10	14
DCAF7	02-Medium	0.37	6.49	G1	C2	—	—	DC.cDC1.cross_presenting (L2), EC.venous.remodeling_stalk (L2), T.CD4_Tcm.retro_ZNF117 (L2)	13	39
ENSG00000288894	02-Medium	0.37	6.49	G1	C2	—	—	—	13	39
NOVA2	02-Medium	0.37	17.94	G2	C2	—	EC.liver_sinusoidal.inflammatory (Tier: relevant)	28 cells — complete matches	73	253
ENSG00000307594	02-Medium	0.37	6.26	G2	C1	—	—	—	3	6
CR1	02-Medium	0.37	4.30	G2	C1	—	macrophage (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD16 (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MONO.CD14.APC_like (Tier: specific) MAC.proliferating (Tier: relevant) MAC.resident_cardiac (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) MAC.kupffer.fibrogenic (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant) MAC.resident_cardiac.phagocytic_homeostasis (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	61 cells — complete matches	23	37
ENSG00000305204	02-Medium	0.37	3.86	G2	C1	—	—	—	12	12
ITGA2B	02-Medium	0.36	5.00	G2	C2	platelet (L1), PLAT.platelet (L1S), MONO.CD14.platelet_bound (L2), MONO.CD16.platelet_bound (L2)	platelet (Tier: relevant) PLAT.platelet (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant) PLAT.adhesion (Tier: relevant)	17 cells — complete matches	4	3
ENSG00000290830	02-Medium	0.36	3.53	G1	C2	—	—	—	6	6
RETREG3	02-Medium	0.36	3.46	G2	C1	—	—	11 cells — complete matches	0	0
PCAT19	02-Medium	0.36	5.16	G2	C2	—	EC.liver_sinusoidal.inflammatory (Tier: relevant)	47 cells — complete matches	0	0
PRKRIP1	02-Medium	0.36	2.92	G1	C2	—	—	B.naive.purinergic (L2), EC.lymphatic.valve (L2), T.CD8_Tcm.gut_homing (L2)	9	10
ENSG00000289323	02-Medium	0.36	6.11	G1	C2	—	—	—	7	15
ENSG00000268401	02-Medium	0.36	17.57	G2	C2	—	—	—	0	0
FBXO46	02-Medium	0.36	12.40	G2	C2	—	—	12 cells — complete matches	14	52
EQTN	02-Medium	0.36	4.97	G2	C1	ASTRO.neuromodulatory (L2)	—	EC.lymphatic.baseline (L2)	5	8
FOXA3	02-Medium	0.35	10.31	G1	C2	—	EPI.renal_distal_tubule.ion_transport (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant)	40 cells — complete matches	85	292
REXO6P.2	02-Medium	0.35	4.20	G2	C1	—	—	—	6	9
TACO1	02-Medium	0.35	6.63	G1	C2	—	—	5 cells — complete matches	6	8
ENSG00000279407	02-Medium	0.35	14.15	G2	C2	—	—	—	14	52
STMN4	02-Medium	0.35	7.46	G1	C2	—	IPSC.mesenchymal_primed (Tier: relevant)	10 cells — complete matches	7	17
PSMC3IP	02-Medium	0.35	3.45	G2	C1	—	MAC.proliferating.DNA_replication (Tier: relevant)	23 cells — complete matches	1	1
ENSG00000310084	02-Medium	0.35	4.61	G2	C1	—	—	—	337	743
ENSG00000287710	02-Medium	0.34	3.40	G2	C1	—	—	—	1	1
ENSG00000307610	02-Medium	0.34	6.48	G2	C1	—	—	—	0	0
ENSG00000253690	02-Medium	0.34	2.62	G1	C2	—	—	—	2	3
SYMPK	02-Medium	0.33	8.47	G1	C2	—	MAC.proliferating.stress (Tier: relevant)	9 cells — complete matches	81	282
ENSG00000226797	02-Medium	0.33	4.56	G1	C2	—	—	—	9	48
ENSG00000303169	02-Medium	0.33	3.54	G1	C2	—	—	—	3	6
ENSG00000307661	02-Medium	0.33	5.14	G1	C2	—	—	—	13	39
ENSG00000302986	02-Medium	0.33	14.44	G2	C2	—	—	—	15	36
LINC02695	02-Medium	0.33	7.85	G1	C2	—	—	—	1	2
HLA-DRB9	02-Medium	0.32	4.66	G2	C1	—	—	—	337	743
RUNDC3A-AS1	02-Medium	0.32	4.11	G2	C2	—	—	6 cells — complete matches	0	0
ENSG00000302962	02-Medium	0.32	11.85	G2	C2	—	—	—	50	314
AXL	02-Medium	0.31	4.18	G2	C2	—	macrophage (Tier: specific) DC.cDC2 (Tier: specific) MAC.MDM (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.microglia_like.inflammatory_chemokine (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant)	44 cells — complete matches	13	25
ENSG00000288045	02-Medium	0.31	5.93	G2	C2	—	—	—	12	63
PGLYRP1	02-Medium	0.31	12.41	G2	C2	—	GRANU.neutrophil (Tier: specific) MONO.CD16.platelet_bound (Tier: relevant)	5 cells — complete matches	0	0
MYPOP	02-Medium	0.31	14.39	G2	C2	—	—	15 cells — complete matches	75	265
SNRPD2	02-Medium	0.31	9.30	G2	C2	—	—	EPI.skin_follicular_keratinizing (L1S), EPI.skin_follicular_keratinizing.transit_amplifying (L2), MG.expanding (L2)	15	53
ENSG00000296745	02-Medium	0.31	3.72	G2	C1	—	—	—	1	1
ENSG00000304245	02-Medium	0.30	1.87	G2	C1	—	—	—	6	9
LINC03078	02-Medium	0.30	7.67	G2	C2	—	—	—	1	1
FAM171A2	02-Medium	0.30	9.58	G2	C2	—	EPI.pancreatic_islet.delta (Tier: relevant)	14 cells — complete matches	4	3
ENSG00000307301	02-Medium	0.29	10.42	G2	C2	—	—	—	13	54
TUBG1	02-Medium	0.29	3.34	G2	C1	—	MAC.proliferating.DNA_replication (Tier: relevant)	4 cells — complete matches	0	0
CR2	02-Medium	0.29	2.65	G2	C1	B.age_associated.naive_transitional (L2), THYMO.SP_CD8_transitional (L2)	—	37 cells — complete matches	14	16
ENSG00000271046	02-Medium	0.29	7.03	G2	C2	—	—	—	1	1
LINGO2	02-Medium	0.29	2.05	G2	C1	NEU.EXC_CT.Ca2_signaling (L2)	—	48 cells — complete matches	2	2
PFKFB2	02-Medium	0.29	1.84	G2	C1	EPI.pancreatic_islet.beta (L2), THYMO.DN_preTCR (L2)	DC.cDC2.proliferative (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant)	28 cells — complete matches	20	33
ENSG00000285664	02-Medium	0.29	5.77	G1	C2	—	—	—	8	37
ENSG00000204850	02-Medium	0.29	10.43	G2	C2	—	—	—	11	31
ENSG00000286971	02-Medium	0.29	5.36	G2	C2	—	—	—	1	0
MS4A1	02-Medium	0.29	4.60	G2	C1	B_cell (L1), B.memory (L1S), B.naive (L1S), B.germinal_center.LZ_selection (L2)	—	67 cells — complete matches	79	120
ELP3	02-Medium	0.29	3.58	G1	C2	—	MAC.proliferating.stress (Tier: relevant)	11 cells — complete matches	13	20
GNPNAT1	02-Medium	0.29	5.46	G1	C2	FIB.perivascular_interface.vasomotor_tone (L2)	—	6 cells — complete matches	8	37
ENSG00000299499	02-Medium	0.28	1.40	G2	C1	—	—	—	4	4
C4BPB	02-Medium	0.28	1.91	G2	C1	—	HEP.periportal_metabolic.xenobiotic_detox (Tier: specific) MAC.resident_repair.lipid_phagocytic (Tier: specific) MAC.resident_iron (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MONO.CD14.repair_M2_like (Tier: relevant)	31 cells — complete matches	20	27
PLAA	02-Medium	0.28	1.41	G2	C1	—	—	B.naive.remodeling (L2), T.CD4_Tcm.imprinted_splicing (L2)	2	5
DPYSL2	02-Medium	0.28	1.63	G1	C2	—	—	11 cells — complete matches	14	29
TEK	02-Medium	0.28	1.07	G2	C1	—	EC.liver_sinusoidal.stress (Tier: specific) EC.liver_sinusoidal.inflammatory (Tier: relevant) EC.liver_sinusoidal.secretory_lipoprotein (Tier: relevant)	55 cells — complete matches	6	9
ENSG00000269151	02-Medium	0.28	10.49	G2	C2	—	—	—	2	32
MLX	02-Medium	0.28	3.41	G2	C1	—	—	ILC2.migratory (L2), T.CD8_Tcm.effector_bias (L2)	39	147
CNTNAP1	02-Medium	0.28	3.37	G2	C1	—	—	13 cells — complete matches	8	21
CCR10	02-Medium	0.28	3.46	G2	C1	T.CD4_Tcm.tissue_homing (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.tissue_enagement (L2)	—	39 cells — complete matches	17	35
COASY	02-Medium	0.28	3.47	G2	C1	—	—	DC.pDC.poised_migratory (L2)	54	164
PNMA8A	02-Medium	0.27	6.88	G2	C2	—	MAC.resident_repair.stress_iron (Tier: relevant)	9 cells — complete matches	19	52
ENSG00000260634	02-Medium	0.27	4.10	G2	C2	—	—	—	1	1
TUBG2	02-Medium	0.27	3.30	G2	C1	—	—	19 cells — complete matches	10	27
PLEKHH3	02-Medium	0.27	3.38	G2	C1	—	GRANU.neutrophil (Tier: specific) GRANU.neutrophil.antiviral_endotoxin (Tier: relevant)	15 cells — complete matches	15	38
ENSG00000267765	02-Medium	0.27	3.32	G2	C1	—	—	—	0	0
ENSG00000267042	02-Medium	0.27	3.44	G2	C1	—	—	—	0	0
ATP6V0A1	02-Medium	0.27	4.24	G2	C2	—	MAC.kupffer.fibrogenic (Tier: relevant) MAC.kupffer.inflammatory (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant)	20 cells — complete matches	24	49
IGFL4	02-Medium	0.27	9.63	G2	C2	EPI.skin_hair_follicle_companion.activated_migratory (L2), EPI.skin_interfollicular_spinous.inflammatory (L2)	—	30 cells — complete matches	0	0
CYP27C1	02-Medium	0.27	6.06	G2	C2	—	—	FIB.adventitial.adhesion_lipid (L2), FIB.transitioning.motility_remodelling (L2)	8	12
ENSG00000294400	02-Medium	0.26	3.82	G2	C2	—	—	—	26	51
GPATCH8	02-Medium	0.26	4.95	G2	C2	—	—	—	4	3
PNMA8B	02-Medium	0.26	9.92	G2	C2	—	—	—	1	2
HSD17B1-AS1	02-Medium	0.26	3.53	G2	C1	—	—	—	1	1
CEACAM21	02-Medium	0.26	6.20	G2	C2	—	MAC.microglia_like (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant)	93 cells — complete matches	5	5
ENSG00000304458	02-Medium	0.26	3.94	G2	C1	—	—	—	1	2
LINC01480	02-Medium	0.25	6.08	G2	C2	—	macrophage (Tier: specific) DC.cDC2 (Tier: specific) MAC.LAM (Tier: specific) dendritic_cell (Tier: relevant) MAC.microglia_like (Tier: relevant) MAC.resident_iron (Tier: relevant) MAC.resident_repair (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) IPSC.stress (Tier: relevant) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.complement_resolving (Tier: relevant) MAC.resident_repair.chemokine_angiocrine (Tier: relevant) MAC.resident_repair.ECM_stromal_crosstalk (Tier: relevant) MAC.resident_repair.stress_iron (Tier: relevant) MG.phagocytic_APC (Tier: relevant)	81 cells — complete matches	0	0
Y_RNA.227	02-Medium	0.25	6.49	G2	C2	—	—	—	0	0
CCDC8	02-Medium	0.25	9.07	G2	C2	—	—	23 cells — complete matches	12	37
ENSG00000289298	02-Medium	0.25	5.98	G2	C2	—	—	—	2	1
RAMP2	02-Medium	0.25	2.33	G2	C1	EC.capillary.baseline (L2), MAC.LAM.perivascular_angiocrine (L2)	MAC.MDM (Tier: specific) EC.liver_sinusoidal.stress (Tier: specific) MAC.MDM.complement_resolving (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant)	82 cells — complete matches	8	18
DDHD1-DT	02-Medium	0.25	2.19	G1	C2	—	—	—	9	33
ENSG00000298666	02-Medium	0.25	0.67	G2	C2	—	—	—	0	0
ENSG00000268027	02-Medium	0.24	5.49	G2	C2	—	—	—	0	0
ENSG00000271075	02-Medium	0.24	7.86	G2	C2	—	—	—	0	0
CYP2S1	02-Medium	0.24	2.61	G2	C2	—	DC.cDC2 (Tier: specific) MAC.MDM (Tier: specific) dendritic_cell (Tier: relevant) MAC.proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) IPSC.mesenchymal_primed (Tier: relevant) IPSC.midbrain_primed (Tier: relevant) IPSC.stress (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant) MAC.proliferating.stress (Tier: relevant)	55 cells — complete matches	7	10
DMAC2	02-Medium	0.23	2.51	G2	C2	—	—	11 cells — complete matches	1	1
ENSG00000300389	02-Medium	0.23	4.88	G2	C2	—	—	—	17	33
ATP1A3	02-Medium	0.23	3.36	G2	C2	—	—	42 cells — complete matches	1	2
ENSG00000306416	02-Medium	0.23	5.42	G2	C2	—	—	—	4	3
ENSG00000285505	02-Medium	0.23	2.95	G2	C2	—	—	—	1	2
ENSG00000283045	02-Medium	0.23	3.82	G2	C2	—	—	—	4	3
ZC3H4	02-Medium	0.22	1.86	G2	C2	—	—	11 cells — complete matches	1	1
ERICH4	02-Medium	0.21	3.44	G2	C2	—	EPI.renal_proximal_tubule (Tier: specific) EPI.renal_proximal_tubule.onecarbon_peroxisome (Tier: relevant)	12 cells — complete matches	0	0
PNMA8C	02-Medium	0.21	6.74	G2	C2	—	—	T.CD8_Tem.baseline (L2), T.CD8_transitional.APC_like (L2)	9	23
ENSG00000255730	02-Medium	0.21	2.09	G2	C2	—	—	—	36	69
ENSG00000301443	02-Medium	0.21	5.63	G2	C2	—	—	—	0	0
BCKDHA	02-Medium	0.21	2.11	G2	C2	—	—	FIB.lung_alveolar.mito_secretory (L2), T.CD4_Tfh.canonical_GC_helper (L2), T.CD4_naive.Treg_like (L2)	13	16
ENSG00000266929	02-Medium	0.19	4.65	G2	C2	—	—	—	17	33
NAGLU	02-Medium	0.19	4.65	G2	C2	—	—	5 cells — complete matches	17	33
EXOSC5	02-Medium	0.18	1.78	G2	C2	—	—	10 cells — complete matches	18	23
LIPE-AS1	02-Medium	0.17	1.88	G2	C2	—	EC.liver_sinusoidal.stress (Tier: specific) MONO.CD14.repair_M2_like (Tier: relevant)	9 cells — complete matches	5	5
ENSG00000267222	02-Medium	0.17	3.56	G2	C2	—	—	—	20	40
SAE1	02-Medium	0.16	2.26	G2	C2	—	—	4 cells — complete matches	1	1
ENSG00000267632	02-Medium	0.16	3.77	G2	C2	—	—	—	21	37
CAVIN1	02-Medium	0.14	3.20	G2	C2	EPI.skin_keratinocyte_proliferating.detox_repair (L2), FIB.barrier_purinergic.lipid_secretory (L2)	—	44 cells — complete matches	38	80
ENSG00000254261	02-Medium	0.13	0.48	G2	C1	—	—	—	3	3

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.