Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000091 · All tissues

Anomalies of dental arch relationship, including avohilmo: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Malocclusion

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	fibroblast	3.56	Nominal	1.59e-15	1.16	Other	184	826
2	adipocyte	3.19	Nominal	1.00	1.03	Other	33	111
3	plasma_cell	2.88	Nonsignificant	0.26	1.05	Other	17	24
4	epithelial_cell	2.60	Nonsignificant	1.65e-49	1.20	Other	24	47
5	T_cell	1.95	Nonsignificant	1.65e-49	1.20	Other	470	959
6	pericyte	1.78	Nonsignificant	1.00	0.98	Other	128	517
7	mesothelial_cell	0.98	Nonsignificant	1.00	0.94	Other	6	36
8	innate_lymphoid_cell_2	0.91	Nonsignificant	1.00	0.94	Other	3	8
9	macrophage	0.71	Nonsignificant	1.00	0.88	Other	813	1,732
10	smooth_muscle_cell	0.69	Nonsignificant	1.00	0.89	Other	27	139
11	endothelial_cell	0.57	Nonsignificant	1.00	0.90	Other	373	974
12	microglia	0.46	Nonsignificant	1.00	0.87	Other	61	129
13	adipose_stem_and_progenitor_cell	0.38	Nonsignificant	1.00	0.81	Other	327	954
14	platelet	0.25	Nonsignificant	—	0.44	Other	85	104
15	granulocyte	0.15	Nonsignificant	1.00	0.80	Other	5	6
16	muscle_stem_cell	0.14	Nonsignificant	1.00	0.71	Other	7	27
17	oligodendrocyte_precursor_cell	0.12	Nonsignificant	1.00	0.59	Other	461	1,454
18	dendritic_cell	0.10	Nonsignificant	1.00	0.65	Other	496	724
19	B_cell	0.10	Nonsignificant	1.00	0.64	Other	356	694
20	melanocyte	0.09	Nonsignificant	1.00	0.61	Other	97	309
21	monocyte	0.07	Nonsignificant	1.00	0.59	Other	2,176	3,871
22	hepatocyte	0.06	Nonsignificant	1.00	0.69	Other	1,515	3,822
23	astrocyte	0.06	Nonsignificant	1.00	0.61	Other	256	1,203
24	haematopoietic_progenitor_cell	0.03	Nonsignificant	1.00	0.55	Other	262	502
25	thymocyte	0.02	Nonsignificant	1.00	0.48	Other	168	512
26	schwann_cell	0.01	Nonsignificant	1.00	0.47	Other	10	57
27	natural_killer_cell	0.01	Nonsignificant	1.00	0.66	Other	1,204	2,052
28	induced_pluripotent_stem_cell	9.50e-03	Nonsignificant	1.00	0.48	Other	0	0
29	chondrocyte	6.44e-03	Nonsignificant	1.00	0.55	Other	548	1,069
30	neuron	6.44e-03	Nonsignificant	1.00	0.57	Other	330	1,328
31	skeletal_muscle_cell	2.11e-03	Nonsignificant	1.00	0.40	Other	944	2,600
32	granulosa_cell	6.80e-04	Nonsignificant	1.00	0.35	Other	293	670
33	cardiomyocyte	3.83e-04	Nonsignificant	1.00	0.38	Other	533	2,045
34	oligodendrocyte	3.10e-04	Nonsignificant	1.00	0.61	Other	385	1,507

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.salivary_serous_acinar	11.72	Significant	3.72e-07	1.19	Specific	233	531
2	EPI.pancreatic_acinar	10.86	Significant	7.07e-06	1.19	Specific	429	1,475
3	EPI.renal_immature_ureteric_bud	9.78	Significant	1.00	1.07	Specific	217	569
4	FIB.adventitial	7.00	Significant	2.26e-49	1.73	Specific	268	1,447
5	T.CD4_Tcm	4.57	Nominal	3.43e-33	1.61	Other	494	988
6	T.CD4_Th17	3.58	Nominal	1.00	1.01	Other	421	794
7	ADIPO.adipocyte	3.19	Nominal	—	—	Other	20	62
8	T.CD4_naive	3.05	Nominal	5.06e-18	1.32	Other	399	866
9	PC.IgA_muocsal	3.05	Nominal	6.18e-03	1.50	Other	18	31
10	T.CD4_Treg	2.94	Nonsignificant	0.25	1.14	Other	244	511
11	EPI.salivary_intercalated_defense	2.90	Nonsignificant	1.00	0.95	Other	81	161
12	MAC.resident_repair	2.62	Nonsignificant	1.20e-06	1.35	Other	796	1,426
13	T.CD4_Tfh	2.46	Nonsignificant	1.00	0.95	Other	47	45
14	T.CD4_transitional	2.40	Nonsignificant	1.00	0.86	Other	48	110
15	T.CD8_Tcm	2.16	Nonsignificant	1.00	0.81	Other	460	926
16	T.CD8_naive	2.14	Nonsignificant	1.00	0.99	Other	317	708
17	EPI.intrahepatic_cholangiocyte_defense	1.98	Nonsignificant	—	0.61	Other	8	13
18	T.CD4_Th2	1.94	Nonsignificant	—	0.20	Other	1	2
19	PERI.pericyte	1.78	Nonsignificant	—	—	Other	117	0
20	EPI.pancreatic_islet	1.73	Nonsignificant	1.00	0.92	Other	52	132
21	EPI.pancreatic_ductal_mucinous	1.73	Nonsignificant	1.00	0.95	Other	219	430
22	EC.arterial	1.71	Nonsignificant	5.02e-18	1.30	Other	356	885
23	PC.IgG_systemic	1.57	Nonsignificant	1.00	0.46	Other	41	60
24	MAC.microglia_like	1.42	Nonsignificant	1.00	1.16	Other	124	179
25	EPI.pancreatic_ductal_bicarbonate	1.42	Nonsignificant	1.00	0.81	Other	131	548
26	EPI.intrahepatic_cholangiocyte_transport	1.38	Nonsignificant	—	0.41	Other	12	42
27	T.CD4_Tem	1.15	Nonsignificant	1.00	0.74	Other	365	697
28	EPI.ileal_bile_transport	1.02	Nonsignificant	1.00	0.92	Other	61	93
29	MESO.mesothelial_cell	0.98	Nonsignificant	—	—	Other	2	18
30	ILC2.innate_lymphoid_cell_2	0.91	Nonsignificant	—	—	Other	2	0
31	EC.heart_remodeling	0.71	Nonsignificant	1.00	1.00	Other	569	1,594
32	SMC.smooth_muscle_cell	0.69	Nonsignificant	—	—	Other	20	101
33	FIB.interstitial	0.67	Nonsignificant	1.00	0.48	Other	288	940
34	EPI.colonic_tuft	0.58	Nonsignificant	—	0.48	Other	7	24
35	EPI.renal_thick_ascending_limb	0.58	Nonsignificant	1.00	0.76	Other	453	1,153
36	EPI.tracheal_submucosal_gland	0.57	Nonsignificant	—	0.41	Other	0	0
37	FIB.lung_alveolar	0.56	Nonsignificant	—	0.00	Other	6	15
38	EPI.gastric_foveolar	0.51	Nonsignificant	—	0.45	Other	0	0
39	MAC.LAM	0.51	Nonsignificant	1.00	0.89	Other	914	2,064
40	EPI.ileal_goblet	0.49	Nonsignificant	1.00	0.80	Other	181	432
41	EPI.renal_distal_tubule	0.46	Nonsignificant	1.00	0.71	Other	133	361
42	MG.microglia	0.46	Nonsignificant	—	—	Other	49	0
43	T.CD4_Trm	0.45	Nonsignificant	1.00	0.56	Other	176	363
44	EPI.hepatic_ductular_cholangiocyte	0.45	Nonsignificant	1.00	0.72	Other	83	243
45	MAC.resident_iron	0.45	Nonsignificant	1.00	0.76	Other	16	21
46	EPI.ileal_enterocyte_crypt	0.45	Nonsignificant	1.00	0.75	Other	67	113
47	MAC.MDM	0.41	Nonsignificant	1.00	0.81	Other	623	986
48	ASPC.adipose_stem_and_progenitor_cell	0.38	Nonsignificant	—	—	Other	324	930
49	FIB.tracheal_subepithelial	0.36	Nonsignificant	—	0.00	Other	0	0
50	MAC.resident_cardiac	0.33	Nonsignificant	1.00	0.69	Other	485	1,074
51	EC.capillary	0.30	Nonsignificant	1.00	0.82	Other	514	1,635
52	EPI.renal_intercalated_cell_type_A	0.27	Nonsignificant	1.00	0.69	Other	67	142
53	PLAT.platelet	0.25	Nonsignificant	—	0.00	Other	38	53
54	GRANU.MAST	0.23	Nonsignificant	9.43e-04	1.74	Other	5	6
55	EPI.salivary_duct_ion_transport	0.23	Nonsignificant	1.00	0.77	Other	5	11
56	EPI.lung_club_secretory	0.22	Nonsignificant	1.00	0.67	Other	5	14
57	DC.mig	0.22	Nonsignificant	—	1.11	Other	89	156
58	EPI.colonocyte	0.20	Nonsignificant	1.00	0.59	Other	294	815
59	EPI.salivary_duct_excretory	0.18	Nonsignificant	1.00	0.62	Other	85	180
60	FIB.barrier_purinergic	0.17	Nonsignificant	—	0.00	Other	1	3
61	T.CD8_transitional	0.15	Nonsignificant	1.00	0.38	Other	497	932
62	MUSC.muscle_stem_cell	0.14	Nonsignificant	—	—	Other	4	18
63	HEP.canalicular_transport	0.14	Nonsignificant	2.66e-07	1.16	Other	1,290	3,434
64	EPI.colonic_enteroendocrine	0.14	Nonsignificant	—	0.12	Other	1	1
65	DC.cDC2	0.12	Nonsignificant	0.03	1.28	Other	1,189	1,793
66	FIB.perivascular_interface	0.12	Nonsignificant	1.00	0.25	Other	0	0
67	EPI.lung_multiciliated	0.12	Nonsignificant	1.00	0.58	Other	16	49
68	B.naive	0.12	Nonsignificant	2.87e-04	1.32	Other	307	595
69	OPC.oligodendrocyte_precursor_cell	0.12	Nonsignificant	—	—	Other	413	1,269
70	EPI.ileal_enterocyte_absorptive	0.11	Nonsignificant	1.00	0.61	Other	118	338
71	T.MAIT	0.11	Nonsignificant	1.00	0.48	Other	469	855
72	B.age_associated	0.11	Nonsignificant	1.00	1.02	Other	207	350
73	EC.venous	0.10	Nonsignificant	1.00	0.64	Other	516	1,387
74	MONO.CD16	0.10	Nonsignificant	0.70	1.03	Other	1,304	1,835
75	FIB.barrier_secretory	0.09	Nonsignificant	1.00	0.25	Other	81	228
76	MEL.melanocyte	0.09	Nonsignificant	—	—	Other	79	242
77	EPI.salivary_myoepithelial	0.09	Nonsignificant	1.00	0.73	Other	191	714
78	EPI.extrahepatic_cholangiocyte	0.09	Nonsignificant	—	0.00	Other	37	71
79	B.memory	0.07	Nonsignificant	1.00	0.71	Other	442	882
80	MONO.CD14	0.07	Nonsignificant	0.93	0.92	Other	2,294	4,139
81	EPI.alveolar_type_1	0.06	Nonsignificant	1.00	0.67	Other	26	101
82	T.CD8_Trm	0.06	Nonsignificant	1.00	0.35	Other	211	346
83	ASTRO.astrocyte	0.06	Nonsignificant	—	—	Other	228	1,111
84	T.gamma_delta	0.05	Nonsignificant	1.00	0.36	Other	588	1,078
85	EPI.bile_duct_cholangiocyte	0.05	Nonsignificant	1.00	0.57	Other	37	60
86	EPI.ectocervical_granular	0.05	Nonsignificant	—	0.00	Other	11	23
87	EC.lymphatic	0.05	Nonsignificant	1.00	0.65	Other	630	998
88	EPI.renal_principal_cell	0.05	Nonsignificant	1.00	0.53	Other	207	403
89	FIB.hepatic_stellate_cell	0.04	Nonsignificant	—	0.00	Other	64	252
90	MAC.kupffer	0.04	Nonsignificant	1.00	0.29	Other	189	530
91	FIB.reticular	0.04	Nonsignificant	1.00	0.14	Other	19	87
92	HPC.haematopoietic_progenitor_cell	0.03	Nonsignificant	—	—	Other	211	370
93	FIB.suburothelial	0.03	Nonsignificant	1.00	0.12	Other	122	432
94	DC.cDC1	0.03	Nonsignificant	1.00	0.73	Other	55	112
95	HEP.periportal_metabolic	0.03	Nonsignificant	1.00	0.91	Other	1,750	4,427
96	FIB.neurolectin_mucosa	0.03	Nonsignificant	1.00	0.08	Other	133	394
97	MAC.proliferating	0.03	Nonsignificant	1.00	0.83	Other	87	253
98	T.CD8_Tem	0.02	Nonsignificant	9.33e-11	1.36	Other	1,083	1,857
99	HEP.pericentral_lipoprotein	0.02	Nonsignificant	—	0.61	Other	0	0
100	FIB.skin_sheath	0.02	Nonsignificant	1.00	0.30	Other	49	118
101	EPI.renal_intercalated_cell_type_B	0.02	Nonsignificant	—	0.00	Other	6	7
102	THYMO.thymocyte	0.02	Nonsignificant	—	—	Other	163	495
103	EPI.skin_hair_follicle_bulge	0.01	Nonsignificant	1.00	0.45	Other	51	178
104	SCHWN.schwann_cell	0.01	Nonsignificant	—	—	Other	7	33
105	EPI.pancreatic_ductal_perivascular	0.01	Nonsignificant	1.00	0.48	Other	4	30
106	NK.natural_killer_cell	0.01	Nonsignificant	—	—	Other	1,204	2,045
107	FIB.skin_neurosecretory	0.01	Nonsignificant	—	0.00	Other	0	0
108	NEU.EXC_IT	0.01	Nonsignificant	1.19e-04	1.11	Other	411	192
109	IPSC.induced_pluripotent_stem_cell	9.50e-03	Nonsignificant	—	—	Other	0	0
110	EPI.tracheal_suprabasal	9.37e-03	Nonsignificant	1.00	0.62	Other	29	56
111	T.CD4_cytotoxic	7.59e-03	Nonsignificant	1.00	0.26	Other	855	1,493
112	EPI.skin_sweat_duct_keratinocyte	7.27e-03	Nonsignificant	1.00	0.64	Other	146	301
113	CHOND.chondrocyte	6.44e-03	Nonsignificant	—	—	Other	519	730
114	FIB.skin_tenogenic	4.46e-03	Nonsignificant	—	0.00	Other	108	227
115	GRANU.neutrophil	4.42e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
116	EPI.skin_interfollicular_spinous	4.22e-03	Nonsignificant	1.00	0.46	Other	260	563
117	SKM.type_2_fast	3.64e-03	Nonsignificant	3.21e-18	1.40	Other	972	2,639
118	MAC.alveolar	3.54e-03	Nonsignificant	1.00	0.63	Other	1,432	3,122
119	EPI.skin_appendage_keratinocyte	2.79e-03	Nonsignificant	1.00	0.45	Other	87	222
120	EPI.skin_keratinocyte_progenitor	1.92e-03	Nonsignificant	—	0.00	Other	0	3
121	EPI.renal_proximal_tubule	1.50e-03	Nonsignificant	1.00	0.33	Other	525	806
122	NEU.INH_VIP	1.06e-03	Nonsignificant	0.99	0.87	Other	241	366
123	EPI.esophageal_basal	8.79e-04	Nonsignificant	1.00	0.34	Other	4	10
124	EPI.alveolar_type_2	8.74e-04	Nonsignificant	1.00	0.33	Other	813	1,853
125	NEU.EXC_CT	7.93e-04	Nonsignificant	0.99	0.96	Other	362	384
126	FIB.transitioning	6.87e-04	Nonsignificant	1.00	2.60e-03	Other	172	497
127	GRNLSA.granulosa_cell	6.80e-04	Nonsignificant	—	—	Other	257	0
128	EPI.thymic_medullary	6.37e-04	Nonsignificant	1.00	0.31	Other	26	133
129	EPI.esophageal_suprabasal	6.29e-04	Nonsignificant	1.00	0.29	Other	158	404
130	EC.liver_sinusoidal	4.54e-04	Nonsignificant	1.00	0.20	Other	1,083	1,925
131	DC.pDC	4.06e-04	Nonsignificant	1.00	0.15	Other	496	1,028
132	EPI.skin_sebaceous_duct_luminal	3.89e-04	Nonsignificant	1.00	0.33	Other	100	249
133	CM.cardiomyocyte	3.83e-04	Nonsignificant	—	—	Other	524	2,032
134	EPI.cervical_suprabasal	3.58e-04	Nonsignificant	—	0.00	Other	14	50
135	OLG.oligodendrocyte	3.10e-04	Nonsignificant	—	—	Other	384	1,397
136	FIB.skin_papillary	1.48e-04	Nonsignificant	—	0.00	Other	0	0
137	NEU.INH_PVALB	8.36e-05	Nonsignificant	0.99	0.73	Other	193	183
138	SKM.type_1_slow	5.87e-05	Nonsignificant	0.63	0.98	Other	923	2,478
139	EPI.thymic_cortical	5.85e-05	Nonsignificant	1.00	0.37	Other	442	824
140	NEU.EXC_NTNG1	2.22e-05	Nonsignificant	—	0.15	Other	0	0
141	EPI.tracheal_basal	1.86e-05	Nonsignificant	1.00	0.20	Other	398	1,120
142	EPI.skin_follicular_keratinizing	1.65e-05	Nonsignificant	1.00	0.18	Other	30	81
143	NEU.INH_LAMP5	1.61e-05	Nonsignificant	0.99	0.60	Other	263	532
144	EPI.pancreatic_ductal_progenitor	1.53e-05	Nonsignificant	1.00	0.18	Other	234	873
145	EPI.skin_hair_follicle_companion	9.38e-06	Nonsignificant	—	0.00	Other	8	12
146	EPI.endocervical_secretory	8.05e-06	Nonsignificant	—	0.00	Other	0	0
147	B.germinal_center	7.14e-06	Nonsignificant	1.00	0.00	Other	233	655
148	HEP.acute_phase	6.55e-06	Nonsignificant	1.00	0.52	Other	1,441	3,641
149	EPI.salivary_mucous_acinar	3.33e-06	Nonsignificant	1.00	0.20	Other	639	1,189
150	NEU.EXC_SYT2	3.28e-06	Nonsignificant	—	0.00	Other	40	77
151	EPI.skin_keratinocyte_basal	6.15e-07	Nonsignificant	—	0.00	Other	13	26
152	EPI.skin_keratinocyte_proliferating	5.12e-09	Nonsignificant	1.00	0.04	Other	47	76

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar.baseline	13.60	Significant	2.50e-03	2.14	—	274	163
2	EPI.salivary_serous_acinar.secretory_active	12.68	Significant	2.28e-13	2.94	—	242	69
3	EPI.pancreatic_acinar.metabolic_onecarbon	12.27	Significant	0.91	1.15	—	287	328
4	EPI.renal_immature_ureteric_bud.defense_secretory	11.71	Significant	0.36	1.22	—	45	76
5	EPI.pancreatic_acinar.adhesion_remodeling	11.14	Significant	1.00	0.54	Relevant	210	784
6	FIB.adventitial.mechano_chemo_sensing	10.29	Significant	0.07	1.54	Specific	135	524
7	EPI.pancreatic_acinar.quiet_dedifferentiation	9.95	Significant	1.00	0.43	—	142	171
8	ASPC.mesothelial_like	9.66	Significant	8.13e-04	1.75	Specific	143	486
9	EPI.renal_immature_ureteric_bud.osmoprotective	9.12	Significant	0.36	1.14	—	126	44
10	FIB.adventitial.PI16_matrix	8.26	Significant	0.63	1.19	Relevant	70	90
11	FIB.adventitial.complement_angiocrine	8.18	Significant	0.79	1.08	Specific	153	684
12	FIB.adventitial.baseline	7.61	Significant	0.87	1.00	Specific	157	278
13	FIB.adventitial.mito_secretory	7.20	Significant	0.98	0.69	—	21	7
14	EPI.pancreatic_acinar.stress	5.75	Significant	1.00	0.25	Other	28	28
15	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	5.58	Significant	2.50e-03	1.46	Other	219	533
16	ADIPO.hypoxia_remodelling	5.48	Nominal	—	0.66	Other	29	105
17	T.CD4_Tcm.secretory	5.42	Nominal	0.66	1.45	Other	20	11
18	T.CD4_Tcm.retro_ZNF117	5.40	Nominal	0.71	1.24	Other	5	9
19	T.CD4_Tcm.synapse_dynamics	5.38	Nominal	0.73	1.12	Other	15	10
20	T.CD4_Tcm.RNA_control	5.37	Nominal	0.71	1.27	Other	96	4
21	T.CD4_Tcm.Th2_like	5.28	Nominal	0.66	1.56	Other	23	55
22	T.CD4_Tcm.Tfh_like	5.11	Nominal	0.71	1.20	Other	102	214
23	T.CD4_Th17.migratory	5.01	Nominal	0.46	1.19	Other	13	23
24	T.CD4_Tcm.baseline	4.93	Nominal	0.66	1.38	Other	61	31
25	EPI.pancreatic_acinar.inflammatory_regenerative	4.91	Nominal	1.00	0.11	Other	25	113
26	T.CD4_Tcm.stress	4.77	Nominal	0.73	1.04	Other	5	11
27	T.CD4_Tcm.tissue_homing	4.66	Nominal	0.73	1.04	Other	78	46
28	T.CD4_Tcm.APC_mimicry	4.58	Nominal	0.74	0.97	Other	54	43
29	EPI.salivary_intercalated_defense.canonical_antimicrobial	4.54	Nominal	0.06	1.52	Other	11	22
30	T.CD4_Tcm.imprinted_splicing	4.25	Nominal	0.73	1.02	Other	6	17
31	ASPC.signal_integrator	4.19	Nominal	—	2.33	Other	0	0
32	T.CD4_Tcm.migratory_cilium	4.18	Nominal	0.92	0.64	Other	5	10
33	T.CD4_Tcm.DC_interact	4.17	Nominal	0.92	0.70	Other	72	32
34	T.CD4_Tcm.crosstalk_myeloid	4.15	Nominal	0.86	0.80	Other	5	4
35	T.CD4_Th17.baseline	4.11	Nominal	0.16	1.49	Other	51	5
36	T.CD8_Tcm.helper_like	4.07	Nominal	6.32e-09	2.18	Other	81	159
37	T.CD4_Treg.central_naive_like	4.04	Nominal	3.73e-03	1.78	Other	333	45
38	FIB.adventitial.adhesion_lipid	3.87	Nominal	0.98	0.75	Other	58	209
39	T.CD4_Tcm.regulatory_poised	3.85	Nominal	0.74	0.94	Other	2	3
40	T.CD4_naive.homeostatic	3.85	Nominal	0.02	1.56	Other	215	108
41	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	3.81	Nominal	—	1.15	Other	0	0
42	T.CD4_Treg.Tr1_like	3.77	Nominal	—	0.57	Other	8	8
43	MAC.microglia_like.patrolling_adhesive	3.65	Nominal	—	1.21	Other	0	0
44	MAC.resident_repair.ECM_stromal_crosstalk	3.61	Nominal	0.17	1.34	Other	95	158
45	T.CD4_naive.mature_mitoprot	3.50	Nominal	0.20	1.33	Other	212	476
46	T.CD4_naive.Treg_like	3.41	Nominal	0.26	1.62	Other	121	72
47	EPI.pancreatic_islet.alpha	3.32	Nominal	—	0.80	Other	152	330
48	T.CD4_naive.survival	3.31	Nominal	1.00	0.89	Other	12	17
49	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	3.26	Nominal	—	1.44	Other	0	0
50	T.CD4_naive.purinergic	3.26	Nominal	0.92	1.09	Other	49	1
51	PC.IgA_muocsal.migratory	3.24	Nominal	0.38	1.14	Other	4	1
52	ADIPO.thermogenic	3.23	Nominal	—	0.44	Other	0	0
53	PC.IgA_muocsal.activated	3.22	Nominal	0.38	1.14	Other	17	8
54	MAC.resident_repair.stress_iron	3.19	Nominal	0.02	1.73	Other	48	97
55	EC.arterial.ion_pump	3.18	Nominal	1.00	0.99	Other	3	2
56	T.CD4_naive.neddylation_mitoprot	3.17	Nominal	0.26	1.33	Other	93	56
57	EPI.salivary_serous_acinar.quiescent	3.13	Nominal	1.00	0.06	Other	178	493
58	T.CD4_naive.survival_mitoprot	3.09	Nominal	1.00	0.88	Other	13	7
59	T.CD4_naive.neddylation	2.99	Nonsignificant	0.92	1.09	Other	104	222
60	EC.arterial.arteriole_gas_exchange	2.96	Nonsignificant	2.42e-03	1.31	Other	238	131
61	EPI.renal_distal_tubule.ciliated_remodelling	2.95	Nonsignificant	—	1.64	Other	0	0
62	PC.IgA_muocsal.baseline	2.93	Nonsignificant	0.91	0.80	Other	3	5
63	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	2.87	Nonsignificant	—	0.42	Other	0	0
64	EC.arterial.arteriole_interface	2.86	Nonsignificant	0.29	1.16	Other	31	12
65	FIB.adventitial.inflammatory_activated	2.85	Nonsignificant	1.00	0.43	Other	100	473
66	T.CD4_Tfh.canonical_GC_helper	2.85	Nonsignificant	0.79	0.94	Other	1	2
67	FIB.adventitial.activated_remodelling	2.83	Nonsignificant	—	0.00	Other	141	319
68	T.CD4_naive.mature	2.82	Nonsignificant	1.00	0.75	Other	211	100
69	MAC.resident_repair.chemokine_angiocrine	2.78	Nonsignificant	1.00	0.93	Other	87	138
70	T.CD8_naive.mito_proteostasis	2.74	Nonsignificant	0.56	1.45	Other	428	100
71	T.CD4_transitional.baseline	2.73	Nonsignificant	0.54	1.21	Other	59	97
72	T.CD4_Treg.APC_interactive	2.69	Nonsignificant	0.71	0.83	Other	118	28
73	PERI.cardiac_skeletal	2.68	Nonsignificant	4.35e-14	2.12	Other	313	630
74	T.CD4_naive.survival_neddylation	2.61	Nonsignificant	1.00	0.56	Other	26	38
75	T.CD4_Tfh.precursor_migratory	2.58	Nonsignificant	0.07	1.57	Other	72	27
76	EC.arterial.mito_contact	2.56	Nonsignificant	0.60	1.09	Other	14	5
77	T.CD4_naive.resist_bystander	2.54	Nonsignificant	1.00	0.56	Other	40	25
78	PC.IgG_systemic.secretory	2.52	Nonsignificant	0.23	1.36	Other	0	0
79	T.CD4_Tfh.effector_migratory	2.48	Nonsignificant	0.79	1.05	Other	122	57
80	T.CD4_Tem.transitional_CM	2.43	Nonsignificant	0.12	1.34	Other	31	20
81	T.CD4_transitional.APC_interacting	2.39	Nonsignificant	0.72	0.94	Other	10	14
82	T.CD8_naive.nfkb_related	2.39	Nonsignificant	0.63	1.20	Other	1	0
83	T.CD4_transitional.tissue_enagement	2.37	Nonsignificant	0.68	1.10	Other	5	11
84	T.CD4_transitional.primed_helper_effector	2.33	Nonsignificant	0.21	1.50	Other	19	43
85	T.CD4_Tcm.effector_like	2.31	Nonsignificant	1.00	0.00	Other	293	533
86	T.CD8_naive.innate_like	2.30	Nonsignificant	0.63	1.15	Other	10	1
87	T.CD8_naive.splicing_enriched	2.29	Nonsignificant	0.63	1.15	Other	120	16
88	T.CD8_naive.baseline	2.26	Nonsignificant	0.56	1.28	Other	142	2
89	T.CD4_Th2.precursor	2.23	Nonsignificant	—	0.00	Other	0	0
90	T.CD8_naive.cytokine_dampened	2.10	Nonsignificant	1.00	0.65	Other	71	4
91	EC.venous.cardiac_structural	2.09	Nonsignificant	0.02	1.32	Other	102	229
92	MESO.secretory_structural	2.07	Nonsignificant	—	0.86	Other	0	0
93	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.00	Nonsignificant	—	0.55	Other	0	0
94	EPI.pancreatic_ductal_bicarbonate.stress	1.99	Nonsignificant	—	0.94	Other	12	33
95	T.CD8_naive.vesicle_secretory	1.99	Nonsignificant	0.92	0.87	Other	42	0
96	PC.IgA_muocsal.plasmablast	1.84	Nonsignificant	0.91	0.82	Other	5	4
97	PERI.angiocrine	1.84	Nonsignificant	0.83	0.95	Other	93	102
98	MAC.resident_repair.antigen_presenting	1.75	Nonsignificant	1.00	0.38	Other	244	113
99	T.CD4_Tfh.suppression_exhaustion	1.72	Nonsignificant	0.79	0.76	Other	0	2
100	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.71	Nonsignificant	—	0.00	Other	0	0
101	T.CD8_naive.lipid_synthesis	1.64	Nonsignificant	0.92	0.76	Other	6	4
102	ILC2.activated	1.62	Nonsignificant	—	0.35	Other	0	0
103	T.CD8_Tcm.gut_homing	1.62	Nonsignificant	0.99	0.66	Other	380	112
104	EC.arterial.angiogenic_tip	1.61	Nonsignificant	—	0.11	Other	30	37
105	EPI.renal_thick_ascending_limb.barrier_repair	1.60	Nonsignificant	1.73e-05	1.84	Other	141	284
106	T.CD4_transitional.primed_cytotoxic	1.56	Nonsignificant	1.00	0.17	Other	28	30
107	T.CD4_Tem.long_term_memory	1.52	Nonsignificant	0.26	1.19	Other	314	587
108	ADIPO.immature	1.50	Nonsignificant	—	0.00	Other	24	40
109	T.CD8_naive.effector_transition	1.50	Nonsignificant	1.00	0.13	Other	35	62
110	T.CD4_naive.proteostasis_mitoprot	1.50	Nonsignificant	1.00	0.11	Other	15	37
111	T.CD4_Th2.tissue_adapted	1.50	Nonsignificant	—	0.00	Other	0	0
112	T.CD4_Treg.tissue_effector	1.42	Nonsignificant	0.71	0.89	Other	16	13
113	T.CD8_Tcm.baseline	1.40	Nonsignificant	0.99	0.40	Other	90	89
114	EPI.salivary_intercalated_defense.inflammatory	1.39	Nonsignificant	0.98	0.16	Other	152	360
115	ADIPO.inflammatory	1.39	Nonsignificant	—	0.00	Other	0	0
116	SMC.metabolic	1.37	Nonsignificant	2.02e-05	1.68	Other	14	40
117	EC.heart_remodeling.capillary_metabolic	1.33	Nonsignificant	0.17	1.52	Other	54	414
118	PC.IgG_systemic.interacting	1.30	Nonsignificant	0.23	1.36	Other	0	0
119	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.30	Nonsignificant	0.94	0.21	Other	449	1,034
120	T.CD4_naive.proteostasis	1.27	Nonsignificant	1.00	0.05	Other	14	9
121	PC.IgG_systemic.stress	1.27	Nonsignificant	—	0.31	Other	1	5
122	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.20	Nonsignificant	—	0.00	Other	0	0
123	T.CD4_Th17.cytotoxic	1.20	Nonsignificant	1.00	0.00	Other	332	123
124	FIB.interstitial.stress_secretory	1.19	Nonsignificant	0.48	1.45	Other	92	56
125	PERI.baseline	1.13	Nonsignificant	0.54	1.09	Other	39	66
126	MAC.microglia_like.phagocytic_redox	1.11	Nonsignificant	—	0.00	Other	0	0
127	T.CD8_Tcm.NK_like	1.11	Nonsignificant	0.99	0.40	Other	334	581
128	MAC.resident_iron.heme_recycling	1.10	Nonsignificant	—	0.92	Other	30	37
129	T.CD8_transitional.stress	1.06	Nonsignificant	—	1.65	Other	24	34
130	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	1.06	Nonsignificant	—	0.63	Other	0	0
131	T.CD8_Tcm.effector_bias	1.05	Nonsignificant	0.99	0.70	Other	199	329
132	EPI.ileal_bile_transport.absorptive_xenobiotic	1.04	Nonsignificant	0.40	1.16	Other	11	12
133	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.00	Nonsignificant	—	1.86	Other	0	0
134	EC.heart_remodeling.remodeling_secretory	0.99	Nonsignificant	0.62	1.11	Other	605	1,341
135	MESO.antiviral	0.98	Nonsignificant	—	0.00	Other	3	8
136	EPI.ileal_bile_transport.detox_transcytosis	0.98	Nonsignificant	—	0.00	Other	0	1
137	T.CD4_Tem.inflammatory	0.97	Nonsignificant	1.00	0.78	Other	28	6
138	EC.heart_remodeling.angiocrine	0.95	Nonsignificant	0.08	1.37	Other	182	525
139	FIB.interstitial.remodeling	0.93	Nonsignificant	0.48	1.19	Other	31	9
140	EPI.salivary_myoepithelial.contractile_repair	0.90	Nonsignificant	—	1.80	Other	3	9
141	MAC.LAM.lipid_opsonization	0.90	Nonsignificant	0.25	1.21	Other	45	14
142	T.CD4_Trm.central_like	0.88	Nonsignificant	0.26	1.23	Other	38	31
143	T.CD4_naive.gut_prone	0.88	Nonsignificant	1.00	4.27e-03	Other	35	70
144	EC.arterial.homeostatic	0.86	Nonsignificant	1.00	0.82	Other	24	3
145	ASPC.niche_keeping_progenitor	0.86	Nonsignificant	0.32	1.43	Other	52	219
146	T.CD4_Trm.metal_stress	0.85	Nonsignificant	0.26	1.36	Other	34	58
147	MESO.activated_migratory	0.85	Nonsignificant	—	0.12	Other	0	0
148	PC.IgG_systemic.metabolic	0.83	Nonsignificant	0.88	0.59	Other	46	63
149	EC.capillary.activated	0.82	Nonsignificant	0.73	1.21	Other	2	5
150	EPI.ileal_enterocyte_crypt.villus_transition	0.79	Nonsignificant	—	1.09	Other	7	10
151	EPI.pancreatic_islet.delta	0.79	Nonsignificant	—	0.00	Other	0	0
152	MESO.baseline	0.78	Nonsignificant	0.91	0.45	Other	0	6
153	EPI.renal_distal_tubule.ion_transport	0.78	Nonsignificant	—	0.33	Other	0	0
154	ILC2.migratory	0.77	Nonsignificant	—	0.00	Other	0	0
155	EC.arterial.inflammatory	0.75	Nonsignificant	1.00	0.82	Other	63	50
156	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.74	Nonsignificant	—	0.70	Other	0	0
157	MAC.LAM.inflammatory_APC	0.74	Nonsignificant	9.71e-03	1.24	Other	872	165
158	MONO.CD16.platelet_bound	0.73	Nonsignificant	0.22	1.55	Other	372	508
159	FIB.interstitial.immune_interact	0.73	Nonsignificant	0.70	1.09	Other	12	1
160	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.72	Nonsignificant	—	0.00	Other	0	0
161	EPI.ileal_enterocyte_crypt.bile_transport	0.70	Nonsignificant	0.78	1.14	Other	2	0
162	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.69	Nonsignificant	—	0.68	Other	0	0
163	EC.arterial.metabolic	0.64	Nonsignificant	1.00	0.81	Other	195	159
164	EPI.lung_club_secretory.ciliogenesis_axoneme	0.64	Nonsignificant	—	0.73	Other	0	0
165	EPI.colonic_tuft.activated	0.64	Nonsignificant	—	0.42	Other	0	0
166	EPI.colonocyte.secretory_boost	0.62	Nonsignificant	0.53	1.23	Other	98	91
167	EPI.tracheal_submucosal_gland.ductal_luminal	0.61	Nonsignificant	—	0.00	Other	0	0
168	MAC.MDM.complement_resolving	0.60	Nonsignificant	0.65	1.21	Other	440	860
169	DC.cDC2.lipid_metabolic	0.60	Nonsignificant	—	0.50	Other	0	0
170	EPI.pancreatic_islet.beta	0.59	Nonsignificant	0.78	0.86	Other	42	57
171	FIB.lung_alveolar.mito_secretory	0.57	Nonsignificant	—	0.00	Other	0	0
172	FIB.lung_alveolar.stress_interacting	0.56	Nonsignificant	—	0.00	Other	0	0
173	MESO.activated_stress	0.55	Nonsignificant	—	0.00	Other	0	0
174	EPI.ileal_goblet.baseline	0.55	Nonsignificant	0.05	2.22	Other	16	2
175	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.54	Nonsignificant	—	0.39	Other	5	3
176	EPI.colonic_tuft.homeostatic	0.53	Nonsignificant	—	0.00	Other	0	0
177	EPI.ileal_enterocyte_crypt.baseline	0.52	Nonsignificant	0.78	1.00	Other	11	6
178	EPI.tracheal_submucosal_gland.acinar_serous	0.52	Nonsignificant	—	0.00	Other	0	0
179	EC.capillary.inflammatory	0.52	Nonsignificant	0.73	1.05	Other	27	51
180	EPI.gastric_foveolar.baseline	0.51	Nonsignificant	—	0.00	Other	0	0
181	MG.baseline	0.51	Nonsignificant	0.37	1.24	Other	16	5
182	T.CD4_Trm.baseline	0.49	Nonsignificant	0.66	1.05	Other	31	21
183	EPI.ileal_goblet.inflammatory_mucin	0.49	Nonsignificant	0.63	0.84	Other	6	9
184	MG.expanding	0.48	Nonsignificant	0.33	1.50	Other	2	1
185	MAC.resident_iron.APC_iron_sensing	0.48	Nonsignificant	0.43	1.15	Other	211	114
186	EPI.ileal_goblet.stress_metallothionein	0.47	Nonsignificant	—	0.00	Other	4	11
187	FIB.interstitial.lipid_matrix	0.47	Nonsignificant	0.97	0.63	Other	258	191
188	PERI.inflammatory	0.47	Nonsignificant	1.00	0.13	Other	40	77
189	SMC.activated	0.47	Nonsignificant	1.00	0.68	Other	2	5
190	FIB.interstitial.mesenchymal_APC	0.47	Nonsignificant	0.97	0.68	Other	81	33
191	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.46	Nonsignificant	1.00	0.72	Other	322	317
192	HEP.canalicular_transport.ductular_like_transition	0.45	Nonsignificant	1.22e-03	1.35	Other	400	87
193	EPI.hepatic_ductular_cholangiocyte.polarity	0.44	Nonsignificant	—	0.00	Other	0	0
194	FIB.interstitial.mesenchymal_regulator	0.43	Nonsignificant	0.89	0.95	Other	4	4
195	EPI.alveolar_type_1.activated	0.43	Nonsignificant	—	1.64	Other	0	0
196	EPI.colonocyte.proximal_transport	0.43	Nonsignificant	0.53	1.23	Other	24	12
197	ASPC.inflammatory	0.41	Nonsignificant	0.92	1.16	Other	21	61
198	MAC.resident_repair.lipid_phagocytic	0.41	Nonsignificant	1.00	0.10	Other	228	604
199	EPI.ileal_enterocyte_crypt.secretory_precursor	0.41	Nonsignificant	—	0.16	Other	0	0
200	EPI.pancreatic_ductal_bicarbonate.baseline	0.40	Nonsignificant	1.00	0.66	Other	11	42
201	MAC.resident_iron.redox_metabolic	0.40	Nonsignificant	0.43	1.23	Other	4	4
202	ILC2.quiescent	0.39	Nonsignificant	—	6.94e-17	Other	0	0
203	EC.capillary.baseline	0.39	Nonsignificant	0.73	1.08	Other	246	560
204	MAC.resident_cardiac.phagocytic_homeostasis	0.38	Nonsignificant	0.68	1.13	Other	564	1,221
205	EPI.renal_thick_ascending_limb.remodeling	0.38	Nonsignificant	1.00	0.80	Other	152	92
206	MG.phagocytic_APC	0.38	Nonsignificant	0.84	0.63	Other	25	8
207	EPI.salivary_intercalated_defense.basal_EMT	0.37	Nonsignificant	—	0.00	Other	0	0
208	ASPC.secretory	0.37	Nonsignificant	1.00	0.96	Other	76	5
209	FIB.tracheal_subepithelial.baseline	0.36	Nonsignificant	—	0.00	Other	0	0
210	MAC.MDM.APC_dendritic	0.36	Nonsignificant	0.71	0.99	Other	48	15
211	T.CD4_naive.activated_stress	0.34	Nonsignificant	1.00	0.00	Other	339	429
212	EPI.ileal_goblet.immature	0.33	Nonsignificant	—	0.00	Other	0	0
213	DC.cDC2.pro_inflammatory	0.33	Nonsignificant	0.06	1.57	Other	3	5
214	T.CD4_Trm.helper_like	0.33	Nonsignificant	0.53	1.15	Other	84	147
215	ASPC.adipocyte_capillary_interface	0.33	Nonsignificant	1.00	0.89	Other	21	54
216	T.CD8_transitional.early	0.32	Nonsignificant	2.77e-03	1.19	Other	327	55
217	MAC.MDM.inflammatory_phagocytic	0.32	Nonsignificant	0.89	0.74	Other	199	52
218	EC.heart_remodeling.activated_acute	0.32	Nonsignificant	1.00	0.50	Other	102	186
219	PLAT.adhesion	0.31	Nonsignificant	—	0.48	Other	0	0
220	EC.heart_remodeling.perivascular	0.31	Nonsignificant	1.00	0.61	Other	124	408
221	EPI.renal_intercalated_cell_type_A.acid_secretion	0.31	Nonsignificant	0.29	1.20	Other	12	6
222	EPI.renal_thick_ascending_limb.cation_flux	0.30	Nonsignificant	1.00	0.51	Other	57	95
223	MONO.CD14.APC_like	0.29	Nonsignificant	6.89e-03	1.31	Other	1,686	2,493
224	GRANU.MAST.resting_granule	0.29	Nonsignificant	—	0.43	Other	0	0
225	EPI.salivary_duct_excretory.stress	0.28	Nonsignificant	0.44	1.25	Other	33	68
226	MAC.microglia_like.inflammatory_chemokine	0.27	Nonsignificant	—	0.00	Other	20	32
227	MAC.MDM.LAM_like	0.27	Nonsignificant	0.71	1.06	Other	12	14
228	T.MAIT.stress	0.27	Nonsignificant	—	0.82	Other	0	0
229	T.CD4_Trm.activated	0.25	Nonsignificant	0.98	0.72	Other	32	26
230	FIB.perivascular_interface.vascular_BM_remodelling	0.25	Nonsignificant	—	0.97	Other	0	0
231	ASPC.remodeling	0.25	Nonsignificant	1.00	0.68	Other	106	354
232	EPI.colonocyte.goblet_interface	0.25	Nonsignificant	—	0.44	Other	11	21
233	OPC.homeostatic	0.24	Nonsignificant	6.72e-03	1.44	Other	394	160
234	MONO.CD14.platelet_bound	0.24	Nonsignificant	0.34	1.25	Other	964	176
235	ASPC.baseline	0.24	Nonsignificant	1.00	0.80	Other	363	170
236	GRANU.MAST.activated_acute	0.23	Nonsignificant	—	0.48	Other	0	0
237	EPI.salivary_duct_ion_transport.baseline	0.23	Nonsignificant	—	—	Other	0	0
238	ASPC.stem_like_progenitor	0.22	Nonsignificant	1.00	0.71	Other	300	842
239	EPI.ectocervical_granular.secretory_apocrine	0.22	Nonsignificant	—	1.15	Other	0	0
240	MAC.resident_cardiac.antigen_presenting	0.22	Nonsignificant	0.68	1.03	Other	52	27
241	DC.mig.baseline	0.22	Nonsignificant	—	0.00	Other	1	0
242	FIB.barrier_purinergic.lipid_secretory	0.22	Nonsignificant	—	0.48	Other	0	0
243	EC.capillary.angiocrine	0.21	Nonsignificant	0.98	0.89	Other	250	630
244	EPI.colonic_enteroendocrine.progenitor	0.20	Nonsignificant	—	0.97	Other	0	0
245	MUSC.activated_migratory	0.20	Nonsignificant	0.85	1.33	Other	6	7
246	EC.capillary.stress	0.20	Nonsignificant	0.98	0.84	Other	44	36
247	EPI.lung_multiciliated.mature_motile_cilia	0.20	Nonsignificant	—	1.53	Other	0	0
248	MAC.LAM.anti_inflammatory	0.20	Nonsignificant	0.55	1.04	Other	86	132
249	EPI.ileal_enterocyte_absorptive.villus_tip	0.19	Nonsignificant	0.02	1.29	Other	4	3
250	MAC.resident_cardiac.inflammatory_reparative	0.19	Nonsignificant	0.68	0.80	Other	31	96
251	T.CD4_Trm.cytotoxic_effector	0.19	Nonsignificant	0.98	0.66	Other	118	77
252	GRANU.MAST.activated_repair	0.19	Nonsignificant	—	0.00	Other	0	1
253	EPI.lung_club_secretory.ciliogenesis_primed	0.18	Nonsignificant	—	0.79	Other	0	0
254	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.18	Nonsignificant	—	0.00	Other	0	0
255	DC.cDC2.tolerogenic_regulatory	0.18	Nonsignificant	0.92	1.10	Other	44	4
256	THYMO.SP_CD8_naive_stress	0.18	Nonsignificant	0.10	1.36	Other	1	1
257	HEP.canalicular_transport.injury_stress	0.18	Nonsignificant	0.96	1.03	Other	289	24
258	T.CD8_transitional.Trm_primed	0.18	Nonsignificant	1.00	0.97	Other	108	15
259	B.naive.restrained	0.18	Nonsignificant	1.97e-03	1.50	Other	183	353
260	EPI.pancreatic_ductal_bicarbonate.activated	0.18	Nonsignificant	1.00	0.22	Other	10	7
261	EC.heart_remodeling.translation_boost	0.18	Nonsignificant	—	0.00	Other	0	0
262	MONO.CD16.hepatic_mac_like	0.17	Nonsignificant	0.65	1.19	Other	803	117
263	MAC.resident_iron.heme_catabolism	0.17	Nonsignificant	0.96	0.42	Other	30	51
264	THYMO.CD8aa_IELp	0.17	Nonsignificant	—	1.30	Other	1	7
265	SMC.contractile	0.17	Nonsignificant	1.00	0.07	Other	80	588
266	MEL.secretory_quiescent	0.17	Nonsignificant	4.72e-03	1.59	Other	19	13
267	ASPC.preadipocyte_lipid_primed	0.16	Nonsignificant	1.00	0.46	Other	331	129
268	EPI.lung_club_secretory.inflammatory	0.16	Nonsignificant	—	0.37	Other	0	0
269	MAC.resident_iron.stress_tolerogenic	0.16	Nonsignificant	—	0.00	Other	0	0
270	EPI.lung_multiciliated.baseline	0.16	Nonsignificant	—	0.51	Other	0	7
271	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.16	Nonsignificant	1.00	0.14	Other	40	191
272	HEP.canalicular_transport.secretory_ERAD_UPR	0.16	Nonsignificant	0.96	1.01	Other	232	28
273	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.16	Nonsignificant	—	0.00	Other	0	0
274	EC.capillary.migratory	0.15	Nonsignificant	0.86	1.00	Other	181	509
275	EPI.colonic_enteroendocrine.Lcell_peptide	0.15	Nonsignificant	—	0.00	Other	0	0
276	ASTRO.synaptic_interaction	0.15	Nonsignificant	0.06	1.37	Other	76	334
277	EPI.ileal_enterocyte_crypt.proliferative_S	0.15	Nonsignificant	0.99	0.34	Other	4	2
278	FIB.barrier_secretory.homeostasis	0.15	Nonsignificant	—	0.60	Other	0	0
279	B.naive.activated	0.14	Nonsignificant	0.98	1.06	Other	77	127
280	ASPC.proliferative	0.14	Nonsignificant	1.00	0.75	Other	33	85
281	EPI.renal_intercalated_cell_type_A.PC_transitional	0.14	Nonsignificant	—	0.00	Other	203	407
282	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.14	Nonsignificant	1.00	0.66	Other	14	32
283	T.CD4_Tem.cytotoxic_effector	0.14	Nonsignificant	1.00	0.06	Other	225	398
284	B.memory.preactivated	0.14	Nonsignificant	0.04	1.39	Other	173	174
285	B.memory.activated	0.14	Nonsignificant	0.02	1.44	Other	105	29
286	EC.heart_remodeling.remodeling_stalk	0.13	Nonsignificant	1.00	0.15	Other	33	111
287	MUSC.baseline	0.13	Nonsignificant	0.85	0.54	Other	0	0
288	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.13	Nonsignificant	—	0.00	Other	6	9
289	EPI.salivary_duct_excretory.baseline	0.13	Nonsignificant	0.98	0.22	Other	23	57
290	PLAT.megakaryocytic	0.13	Nonsignificant	—	0.00	Other	0	0
291	B.age_associated.activated	0.13	Nonsignificant	—	0.33	Other	18	22
292	T.MAIT.migratory	0.13	Nonsignificant	0.59	1.23	Other	10	1
293	MUSC.early_activation	0.13	Nonsignificant	0.85	1.03	Other	4	32
294	MONO.CD16.baseline	0.13	Nonsignificant	0.65	1.07	Other	50	1
295	EC.arterial.elastic	0.13	Nonsignificant	1.00	0.52	Other	22	45
296	EPI.renal_distal_tubule.repair	0.13	Nonsignificant	—	0.00	Other	34	102
297	B.age_associated.naive_transitional	0.12	Nonsignificant	—	0.46	Other	0	0
298	T.gamma_delta.central_memory	0.12	Nonsignificant	1.29e-03	1.37	Other	460	919
299	EPI.renal_distal_tubule.stress	0.12	Nonsignificant	—	0.00	Other	0	0
300	T.MAIT.early_activation	0.12	Nonsignificant	0.59	1.10	Other	57	4
301	MUSC.quiescent_reservoir	0.12	Nonsignificant	0.85	0.66	Other	2	8
302	T.CD8_Tem.early_helper_like	0.12	Nonsignificant	0.26	1.08	Other	445	755
303	B.naive.proteostasis	0.12	Nonsignificant	0.98	1.11	Other	49	69
304	T.MAIT.cytotoxic	0.11	Nonsignificant	0.59	1.14	Other	52	15
305	B.naive.antigen_presenting_ready	0.11	Nonsignificant	0.98	0.94	Other	48	73
306	T.MAIT.MAPK_brake	0.11	Nonsignificant	0.59	1.24	Other	44	66
307	T.CD4_Trm.stress_adaptive	0.11	Nonsignificant	0.98	0.68	Other	8	22
308	HEP.canalicular_transport.baseline	0.11	Nonsignificant	0.96	0.95	Other	199	477
309	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	0.11	Nonsignificant	—	0.00	Other	49	237
310	EC.lymphatic.scavenger	0.11	Nonsignificant	0.13	1.31	Other	203	257
311	HEP.canalicular_transport.pericentral_like_hypoxia	0.10	Nonsignificant	1.00	0.87	Other	326	8
312	MAC.LAM.lipid_phagocytosis	0.10	Nonsignificant	0.16	1.22	Other	369	328
313	FIB.barrier_purinergic.stress_GF_binding	0.10	Nonsignificant	—	0.00	Other	0	0
314	B.naive.purinergic	0.10	Nonsignificant	0.98	0.90	Other	384	820
315	ASTRO.A2_reactive	0.10	Nonsignificant	0.86	1.14	Other	10	37
316	T.MAIT.vesicle	0.10	Nonsignificant	0.80	0.82	Other	37	65
317	EPI.bile_duct_cholangiocyte.secretory_mucin	0.10	Nonsignificant	—	0.76	Other	7	12
318	MAC.kupffer.tolerogenic	0.10	Nonsignificant	—	1.22	Other	45	49
319	B.naive.remodeling	0.10	Nonsignificant	0.98	0.73	Other	135	230
320	HPC.MPP_IEG	0.09	Nonsignificant	0.66	1.22	Other	45	46
321	ASTRO.stress_mito	0.09	Nonsignificant	0.86	1.07	Other	47	110
322	FIB.perivascular_interface.vasomotor_tone	0.09	Nonsignificant	—	0.00	Other	0	0
323	EPI.renal_principal_cell.inflammatory	0.09	Nonsignificant	0.63	1.36	Other	74	157
324	T.CD8_Trm.homeostatic	0.09	Nonsignificant	0.11	1.26	Other	42	5
325	NEU.EXC_IT.neuromodulated	0.09	Nonsignificant	0.31	1.15	Other	176	116
326	DC.cDC2.adhesion_signaling	0.09	Nonsignificant	0.92	0.88	Other	35	9
327	FIB.reticular.ECM_builder	0.09	Nonsignificant	—	0.28	Other	0	0
328	NK.cytokine_repair_primed	0.09	Nonsignificant	0.02	1.10	Other	266	11
329	B.naive.metabolic	0.09	Nonsignificant	0.98	1.02	Other	50	79
330	B.age_associated.migratory	0.08	Nonsignificant	0.87	0.44	Other	2	2
331	EC.capillary.postcap_venule	0.08	Nonsignificant	0.73	1.07	Other	355	261
332	MEL.neurotrophic_migratory	0.08	Nonsignificant	—	0.14	Other	0	0
333	NK.immature_bridge	0.08	Nonsignificant	0.62	1.04	Other	117	122
334	HPC.GMP_granulocytic	0.08	Nonsignificant	—	0.28	Other	3	3
335	MAC.LAM.antimicrobial	0.08	Nonsignificant	1.00	0.53	Other	389	93
336	MEL.stress_glucocorticoid	0.08	Nonsignificant	0.96	0.91	Other	11	34
337	EPI.renal_thick_ascending_limb.salt_sensing	0.08	Nonsignificant	1.00	0.06	Other	73	103
338	EPI.colonocyte.crypt_progenitor	0.08	Nonsignificant	1.00	0.76	Other	115	265
339	DC.cDC1.homeostatic_inhibitory	0.08	Nonsignificant	—	1.01	Other	0	0
340	ASPC.activated	0.08	Nonsignificant	1.00	0.56	Other	164	162
341	EPI.colonocyte.distal_absorptive	0.07	Nonsignificant	—	0.34	Other	0	0
342	EPI.renal_distal_tubule.immune_modulatory	0.07	Nonsignificant	—	0.00	Other	0	0
343	T.CD8_Trm.muscosal_Tc17	0.07	Nonsignificant	0.89	1.01	Other	19	38
344	B.naive.baseline	0.07	Nonsignificant	0.98	0.50	Other	10	13
345	FIB.neurolectin_mucosa.remodeling_repair	0.07	Nonsignificant	—	0.89	Other	4	2
346	MONO.CD16.inflammatory	0.07	Nonsignificant	0.87	0.92	Other	1,640	168
347	EPI.lung_multiciliated.stress	0.07	Nonsignificant	—	0.00	Other	67	165
348	T.MAIT.quiescent	0.07	Nonsignificant	1.00	0.18	Other	100	5
349	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.06	Nonsignificant	—	0.00	Other	0	0
350	HEP.periportal_metabolic.canonical_urea_cycle	0.06	Nonsignificant	0.03	1.17	Other	1,464	269
351	DC.cDC2.migratory	0.06	Nonsignificant	0.92	0.72	Other	185	39
352	B.memory.baseline	0.06	Nonsignificant	1.00	0.72	Other	472	99
353	MONO.CD14.repair_M2_like	0.06	Nonsignificant	0.79	1.00	Other	550	1,495
354	EPI.colonocyte.ionocyte_BEST4	0.06	Nonsignificant	1.00	0.71	Other	103	188
355	DC.cDC2.antiviral	0.06	Nonsignificant	0.92	0.64	Other	100	37
356	EPI.skin_sweat_duct_keratinocyte.barrier	0.06	Nonsignificant	—	1.52	Other	0	0
357	OPC.proliferative_immune_interact	0.06	Nonsignificant	1.00	0.73	Other	180	373
358	DC.cDC2.monocyte_like	0.06	Nonsignificant	0.92	0.76	Other	1,285	791
359	EPI.renal_principal_cell.canonical_vasopressin	0.06	Nonsignificant	0.63	1.34	Other	2	0
360	ASTRO.homeostatic	0.06	Nonsignificant	0.87	0.95	Other	200	431
361	T.CD8_Trm.cytotoxic	0.06	Nonsignificant	0.89	0.94	Other	165	85
362	FIB.skin_sheath.stress_chaperone	0.06	Nonsignificant	—	0.59	Other	0	0
363	B.naive.receptor_recycle	0.06	Nonsignificant	0.98	0.59	Other	51	0
364	EC.venous.baseline	0.06	Nonsignificant	0.84	1.03	Other	346	807
365	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.05	Nonsignificant	—	0.00	Other	19	54
366	NK.adaptive_classII_inhibitory	0.05	Nonsignificant	0.46	1.05	Other	880	154
367	MEL.dedifferentiated_migratory	0.05	Nonsignificant	—	0.00	Other	0	0
368	HPC.GMP_inflammatory	0.05	Nonsignificant	0.72	1.13	Other	20	10
369	MONO.CD14.baseline	0.05	Nonsignificant	1.00	0.75	Other	2,268	76
370	B.memory.pDC_imprint	0.05	Nonsignificant	1.00	0.62	Other	157	103
371	EC.capillary.angiogenic_tip	0.05	Nonsignificant	0.98	0.60	Other	186	218
372	EPI.renal_principal_cell.injury_repair	0.05	Nonsignificant	0.74	1.07	Other	26	9
373	FIB.hepatic_stellate_cell.contractile	0.05	Nonsignificant	—	1.15	Other	0	0
374	FIB.reticular.stromal_niche	0.05	Nonsignificant	0.29	1.19	Other	0	0
375	T.CD4_cytotoxic.precursor	0.05	Nonsignificant	0.13	1.29	Other	156	67
376	EPI.hepatic_ductular_cholangiocyte.stress	0.05	Nonsignificant	—	0.00	Other	0	0
377	MAC.kupffer.monocyte_like	0.04	Nonsignificant	—	0.11	Other	0	0
378	FIB.suburothelial.urothelial_interface	0.04	Nonsignificant	0.02	1.66	Other	9	8
379	HEP.periportal_metabolic.stress_chaperone	0.04	Nonsignificant	—	0.04	Other	66	128
380	ASTRO.neuromodulatory	0.04	Nonsignificant	0.86	1.07	Other	34	172
381	FIB.hepatic_stellate_cell.inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
382	EPI.skin_interfollicular_spinous.upper_lipid	0.04	Nonsignificant	—	1.68	Other	6	6
383	T.CD8_Trm.inflammatory	0.04	Nonsignificant	0.89	0.93	Other	124	176
384	DC.cDC1.cross_presenting	0.04	Nonsignificant	—	0.00	Other	0	0
385	EC.lymphatic.activated	0.04	Nonsignificant	0.75	1.05	Other	47	73
386	MAC.kupffer.stress	0.04	Nonsignificant	0.31	1.14	Other	9	3
387	FIB.hepatic_stellate_cell.fibrogenic	0.04	Nonsignificant	—	0.00	Other	0	0
388	MAC.proliferating.DNA_replication	0.04	Nonsignificant	0.15	1.15	Other	3	6
389	FIB.neurolectin_mucosa.nerve_interface	0.04	Nonsignificant	—	0.78	Other	4	0
390	ASTRO.hypoxia_angiogenic	0.04	Nonsignificant	0.87	0.88	Other	5	18
391	T.gamma_delta.early_effector	0.04	Nonsignificant	1.00	0.80	Other	89	0
392	HEP.periportal_metabolic.urea_onecarbon_secretory	0.04	Nonsignificant	0.59	1.03	Other	1,332	3,053
393	FIB.suburothelial.homeostasis_matrix	0.03	Nonsignificant	0.03	1.60	Other	258	921
394	MONO.CD14.remodeling	0.03	Nonsignificant	1.00	0.74	Other	2,373	295
395	EC.lymphatic.baseline	0.03	Nonsignificant	0.97	0.73	Other	38	72
396	EPI.renal_principal_cell.activated_acute	0.03	Nonsignificant	0.91	0.73	Other	29	59
397	MAC.kupffer.inflammatory	0.03	Nonsignificant	—	0.12	Other	7	4
398	EPI.ileal_enterocyte_absorptive.brush_border	0.03	Nonsignificant	0.05	1.25	Other	580	1,717
399	CHOND.remodeling	0.03	Nonsignificant	—	0.82	Other	5	0
400	MAC.LAM.perivascular_angiocrine	0.03	Nonsignificant	—	0.00	Other	53	138
401	ASTRO.immature_lipid	0.03	Nonsignificant	1.00	0.72	Other	23	113
402	HEP.periportal_metabolic.xenobiotic_detox	0.03	Nonsignificant	0.40	1.06	Other	1,440	139
403	EPI.lung_club_secretory.canonical_surfactant	0.03	Nonsignificant	—	0.00	Other	74	104
404	EPI.salivary_myoepithelial.baseline	0.02	Nonsignificant	0.99	0.83	Other	42	141
405	MAC.kupffer.fibrogenic	0.02	Nonsignificant	—	0.00	Other	0	0
406	B.memory.migratory	0.02	Nonsignificant	1.00	0.28	Other	123	208
407	EPI.colonocyte.junction_remodeling	0.02	Nonsignificant	1.00	0.21	Other	218	305
408	FIB.perivascular_interface.lipid_shuttle	0.02	Nonsignificant	—	0.00	Other	51	170
409	EPI.pancreatic_ductal_perivascular.baseline	0.02	Nonsignificant	0.05	1.44	Other	1	5
410	EPI.tracheal_suprabasal.secretory_immune	0.02	Nonsignificant	—	0.90	Other	0	0
411	MONO.CD16.patrolling	0.02	Nonsignificant	1.00	0.14	Other	797	216
412	IPSC.axial_identity_primed	0.02	Nonsignificant	0.15	1.06	Other	0	0
413	OPC.premyelinating	0.02	Nonsignificant	1.00	0.08	Other	185	12
414	HEP.pericentral_lipoprotein.ApoB_coagulation	0.02	Nonsignificant	—	0.67	Other	0	0
415	FIB.suburothelial.inflammatory_prostanoid	0.02	Nonsignificant	—	0.00	Other	0	0
416	EPI.renal_intercalated_cell_type_B.baseline	0.02	Nonsignificant	—	0.00	Other	3	1
417	MEL.mature_oxidative_traffic	0.02	Nonsignificant	1.00	0.05	Other	247	285
418	HEP.pericentral_lipoprotein.UPR_redox	0.02	Nonsignificant	—	0.00	Other	0	0
419	MAC.alveolar.stress_metabolic	0.02	Nonsignificant	0.57	1.30	Other	116	148
420	IPSC.mesendo_primed	0.02	Nonsignificant	0.15	1.05	Other	0	0
421	EPI.renal_principal_cell.intercalated_like	0.02	Nonsignificant	0.95	0.35	Other	63	66
422	FIB.barrier_secretory.remodeling	0.02	Nonsignificant	—	0.00	Other	0	0
423	EPI.salivary_myoepithelial.activated	0.02	Nonsignificant	0.99	0.58	Other	85	281
424	FIB.reticular.immune_interface	0.02	Nonsignificant	—	0.00	Other	1	6
425	EPI.extrahepatic_cholangiocyte.barrier_interface	0.02	Nonsignificant	—	0.00	Other	0	0
426	EC.lymphatic.tip_migratory	0.02	Nonsignificant	0.97	0.66	Other	23	37
427	SCHWN.translation_boost	0.02	Nonsignificant	—	0.00	Other	8	1
428	IPSC.mesodermal_primed	0.02	Nonsignificant	1.00	0.96	Other	0	0
429	EPI.skin_hair_follicle_bulge.quiescent	0.02	Nonsignificant	0.25	1.26	Other	56	69
430	IPSC.endoderm_primed	0.02	Nonsignificant	0.05	1.20	Other	0	0
431	DC.cDC1.activated	0.02	Nonsignificant	—	0.00	Other	0	0
432	NK.adaptive_HLAE_tuned	0.02	Nonsignificant	0.02	1.07	Other	1,124	189
433	EC.venous.quiescent_homeostatic	0.02	Nonsignificant	1.00	0.78	Other	456	360
434	CHOND.articular_collagen	0.02	Nonsignificant	0.29	1.06	Other	551	266
435	SCHWN.axon_contact_cardiac	0.01	Nonsignificant	0.36	1.14	Other	18	63
436	T.CD8_Tem.stress_adapted	0.01	Nonsignificant	0.81	1.03	Other	607	520
437	T.CD8_transitional.APC_like	0.01	Nonsignificant	1.00	0.55	Other	205	62
438	MONO.CD14.cord_tolerance	0.01	Nonsignificant	0.79	1.01	Other	864	753
439	FIB.suburothelial.contractile_myofibroblast	0.01	Nonsignificant	—	0.00	Other	9	0
440	EC.lymphatic.valve	0.01	Nonsignificant	—	0.04	Other	0	0
441	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.01	Nonsignificant	—	0.00	Other	10	20
442	FIB.skin_neurosecretory.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
443	T.CD8_Tem.baseline	0.01	Nonsignificant	0.81	1.02	Other	458	356
444	EC.venous.activated	0.01	Nonsignificant	1.00	0.66	Other	247	752
445	THYMO.DP_early_stress	0.01	Nonsignificant	—	0.98	Other	0	0
446	IPSC.mesenchymal_primed	0.01	Nonsignificant	7.79e-07	1.17	Other	0	0
447	EC.venous.remodeling_stalk	0.01	Nonsignificant	1.00	0.89	Other	559	566
448	EPI.skin_hair_follicle_bulge.anagen_growth	0.01	Nonsignificant	—	0.27	Other	0	0
449	HEP.canalicular_transport.inflammatory	0.01	Nonsignificant	1.00	0.32	Other	1,335	194
450	NEU.EXC_IT.structural	0.01	Nonsignificant	1.00	0.97	Other	171	41
451	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.01	Nonsignificant	—	0.00	Other	29	88
452	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.01	Nonsignificant	—	0.00	Other	0	0
453	EPI.salivary_myoepithelial.junctional_transport	9.85e-03	Nonsignificant	0.99	0.23	Other	66	121
454	IPSC.stromal_primed	9.39e-03	Nonsignificant	1.00	0.98	Other	0	0
455	MONO.CD14.inflammatory	9.38e-03	Nonsignificant	1.00	0.74	Other	92	134
456	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	9.07e-03	Nonsignificant	0.08	1.23	Other	7	16
457	THYMO.SP_CD8_naive	8.60e-03	Nonsignificant	0.93	0.96	Other	297	177
458	DC.cDC1.proliferative	8.60e-03	Nonsignificant	—	0.00	Other	0	0
459	GRANU.neutrophil.antiviral_endotoxin	8.45e-03	Nonsignificant	—	0.64	Other	0	0
460	SCHWN.reactive_inflammatory	8.24e-03	Nonsignificant	—	0.00	Other	0	0
461	HPC.LMPP	7.99e-03	Nonsignificant	0.94	0.82	Other	65	31
462	THYMO.proliferative_S	7.80e-03	Nonsignificant	0.93	0.98	Other	163	418
463	EPI.alveolar_type_1.baseline	6.69e-03	Nonsignificant	1.00	0.00	Other	8	0
464	HPC.CLP_B_primed	6.28e-03	Nonsignificant	—	0.14	Other	0	0
465	EC.venous.adipose_lipid	6.03e-03	Nonsignificant	1.00	0.71	Other	254	476
466	FIB.reticular.stress_metallothionein	5.79e-03	Nonsignificant	—	0.00	Other	3	32
467	T.CD8_transitional.effector_primed	5.72e-03	Nonsignificant	1.00	0.29	Other	435	151
468	EPI.bile_duct_cholangiocyte.inflammatory_APC	5.36e-03	Nonsignificant	—	0.00	Other	2	0
469	T.CD8_Trm.dendritic_recruiter	5.23e-03	Nonsignificant	1.00	0.44	Other	47	85
470	SKM.type_2_fast.glycolytic_IIx_IIb	4.90e-03	Nonsignificant	0.05	1.26	Other	565	1,482
471	ASTRO.A1_reactive	4.77e-03	Nonsignificant	1.00	0.33	Other	433	394
472	MAC.kupffer.metabolic	4.52e-03	Nonsignificant	—	0.00	Other	25	36
473	T.gamma_delta.cytotoxic_effector	4.50e-03	Nonsignificant	1.00	0.17	Other	349	109
474	FIB.skin_tenogenic.baseline	4.46e-03	Nonsignificant	—	0.00	Other	0	2
475	ASTRO.stress_acute	4.30e-03	Nonsignificant	0.87	0.98	Other	60	56
476	NEU.INH_VIP.serotonergic	4.03e-03	Nonsignificant	—	0.72	Other	9	2
477	DC.cDC1.baseline	3.98e-03	Nonsignificant	—	0.00	Other	0	0
478	EPI.ectocervical_granular.inflammatory	3.90e-03	Nonsignificant	—	0.32	Other	0	0
479	NEU.INH_VIP.enkephalinergic	3.87e-03	Nonsignificant	—	1.23	Other	0	0
480	T.CD4_cytotoxic.baseline	3.65e-03	Nonsignificant	0.94	0.96	Other	0	0
481	THYMO.DP_early	3.51e-03	Nonsignificant	0.93	0.90	Other	326	313
482	THYMO.DN_preTCR	3.41e-03	Nonsignificant	0.93	1.00	Other	41	71
483	IPSC.neural_primed	3.16e-03	Nonsignificant	4.70e-05	1.20	Other	0	0
484	DC.cDC2.proliferative	3.13e-03	Nonsignificant	—	0.00	Other	39	71
485	FIB.neurolectin_mucosa.inflammatory	3.12e-03	Nonsignificant	0.95	0.55	Other	52	110
486	EPI.alveolar_type_2.baseline_surfactant	2.91e-03	Nonsignificant	0.50	1.12	Other	64	9
487	SKM.type_2_fast.oxidative_IIa	2.90e-03	Nonsignificant	0.87	0.85	Other	946	56
488	EPI.renal_proximal_tubule.onecarbon_peroxisome	2.85e-03	Nonsignificant	0.05	1.57	Other	58	89
489	T.CD4_cytotoxic.activated	2.80e-03	Nonsignificant	0.94	0.94	Other	3	1
490	NK.cytokine_lung_immediate_early	2.71e-03	Nonsignificant	1.00	1.04	Other	424	274
491	EPI.skin_keratinocyte_progenitor.activated_stress	2.70e-03	Nonsignificant	—	0.38	Other	0	0
492	NK.adaptive_immature_precursor	2.68e-03	Nonsignificant	1.00	0.96	Other	358	111
493	GRANU.neutrophil.primed_degranulation	2.64e-03	Nonsignificant	—	0.00	Other	0	0
494	GRNLSA.stress_metabolic	2.57e-03	Nonsignificant	—	0.66	Other	1	2
495	EC.liver_sinusoidal.prostanoid	2.56e-03	Nonsignificant	—	0.87	Other	11	64
496	NEU.INH_VIP.LAMP5_hybrid	2.28e-03	Nonsignificant	—	0.96	Other	1	9
497	FIB.skin_sheath.neuro_vascular_interface	2.20e-03	Nonsignificant	—	0.00	Other	0	0
498	FIB.neurolectin_mucosa.axon_responsive	1.86e-03	Nonsignificant	0.95	0.38	Other	10	10
499	FIB.transitioning.secretory_procollagen	1.79e-03	Nonsignificant	—	0.78	Other	0	0
500	EPI.skin_interfollicular_spinous.stress_UPR	1.75e-03	Nonsignificant	—	0.77	Other	0	0
501	HEP.periportal_metabolic.apolipoprotein_secretory	1.75e-03	Nonsignificant	1.00	0.83	Other	43	110
502	OLG.stress	1.56e-03	Nonsignificant	0.59	1.07	Other	232	8
503	NEU.EXC_CT.projector	1.53e-03	Nonsignificant	0.15	1.19	Other	87	26
504	GRANU.neutrophil.tissue_patrolling	1.50e-03	Nonsignificant	—	0.00	Other	0	0
505	THYMO.SP_CD4_naive	1.48e-03	Nonsignificant	0.93	0.68	Other	65	75
506	FIB.skin_sheath.ECM_immune	1.30e-03	Nonsignificant	—	0.00	Other	0	0
507	HPC.MPP_activated	1.25e-03	Nonsignificant	—	0.00	Other	0	0
508	NK.cytokine_tissue_resident	1.23e-03	Nonsignificant	1.00	1.00	Other	74	82
509	T.CD4_cytotoxic.terminal_effector	1.18e-03	Nonsignificant	0.94	0.79	Other	286	21
510	EPI.esophageal_basal.activated_progenitor	1.17e-03	Nonsignificant	0.03	1.39	Other	1	0
511	DC.pDC.poised_migratory	1.16e-03	Nonsignificant	0.55	1.16	Other	54	95
512	HEP.periportal_metabolic.stress_checkpoint	1.15e-03	Nonsignificant	1.00	0.80	Other	234	786
513	EPI.skin_interfollicular_spinous.baseline	1.14e-03	Nonsignificant	1.00	0.99	Other	35	3
514	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.14e-03	Nonsignificant	0.08	1.28	Other	2	9
515	GRNLSA.EMT_insulin_signaling	1.12e-03	Nonsignificant	0.40	1.26	Other	47	84
516	NEU.INH_VIP.nuclear_reg	1.06e-03	Nonsignificant	—	0.42	Other	20	4
517	CM.contractile_oxphos	9.99e-04	Nonsignificant	0.76	1.07	Other	6	19
518	EPI.esophageal_suprabasal.differentiating_keratin	9.55e-04	Nonsignificant	0.04	1.18	Other	131	61
519	GRNLSA.cholesterol_mevalonate	9.19e-04	Nonsignificant	0.51	1.15	Other	9	4
520	NEU.INH_VIP.develop_niche	8.89e-04	Nonsignificant	—	0.72	Other	0	0
521	NEU.EXC_IT.transitional	8.87e-04	Nonsignificant	1.00	1.02	Other	237	142
522	FIB.transitioning.matrix_stress	8.70e-04	Nonsignificant	—	0.12	Other	47	138
523	EPI.skin_interfollicular_spinous.inflammatory	8.67e-04	Nonsignificant	—	0.00	Other	0	0
524	EPI.thymic_medullary.stress_APC	8.59e-04	Nonsignificant	0.62	1.20	Other	2	4
525	HPC.MEP	8.45e-04	Nonsignificant	0.94	0.63	Other	599	1,195
526	CM.baseline	8.32e-04	Nonsignificant	0.76	1.02	Other	393	0
527	NK.cytokine_axis_baseline	7.59e-04	Nonsignificant	1.00	0.95	Other	1,172	116
528	GRNLSA.chemokine_mechanosensory	7.50e-04	Nonsignificant	0.51	1.10	Other	1	0
529	THYMO.SP_CD8_transitional	7.37e-04	Nonsignificant	0.93	0.66	Other	32	75
530	EPI.alveolar_type_2.injury_primed	7.24e-04	Nonsignificant	0.73	1.02	Other	434	245
531	EPI.thymic_medullary.hormone_xeno_barrier	7.07e-04	Nonsignificant	—	0.18	Other	0	8
532	EPI.skin_interfollicular_spinous.early_differentiation	6.73e-04	Nonsignificant	1.00	0.70	Other	89	19
533	THYMO.proliferative_G2M	6.73e-04	Nonsignificant	—	0.00	Other	164	413
534	GRNLSA.lipid_hypoxia	5.93e-04	Nonsignificant	0.51	1.09	Other	28	0
535	EPI.pancreatic_ductal_perivascular.protective_antioxidant	5.85e-04	Nonsignificant	—	0.00	Other	11	69
536	EC.liver_sinusoidal.hypoxia_metabolic	5.73e-04	Nonsignificant	0.63	1.09	Other	183	107
537	NEU.INH_VIP.excitatory_coupled	5.63e-04	Nonsignificant	—	0.00	Other	13	0
538	EPI.renal_proximal_tubule.detox_antioxidant	5.24e-04	Nonsignificant	1.00	0.00	Other	394	77
539	EPI.thymic_medullary.canonical_alarmin	5.10e-04	Nonsignificant	0.69	0.83	Other	8	17
540	NEU.EXC_CT.remodeling	5.10e-04	Nonsignificant	—	0.35	Other	23	1
541	T.CD4_cytotoxic.NK_adapted	5.06e-04	Nonsignificant	0.94	0.69	Other	82	33
542	NEU.INH_VIP.canonical_disinhibitory	4.95e-04	Nonsignificant	0.71	0.83	Other	59	38
543	EPI.cervical_suprabasal.inflammatory_repair	4.73e-04	Nonsignificant	—	0.00	Other	0	0
544	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	4.48e-04	Nonsignificant	—	0.80	Other	0	0
545	GRNLSA.proliferative_migratory	4.18e-04	Nonsignificant	0.86	0.92	Other	248	292
546	NEU.INH_VIP.matrix	3.43e-04	Nonsignificant	—	0.00	Other	24	77
547	NK.cytokine_quiescent	3.42e-04	Nonsignificant	1.00	1.00	Other	623	1,062
548	EPI.thymic_medullary.proliferative_APC	3.34e-04	Nonsignificant	—	0.00	Other	0	0
549	CM.osmoprotection	3.03e-04	Nonsignificant	0.77	1.03	Other	34	57
550	NK.cytokine_vascular_patrolling	3.02e-04	Nonsignificant	1.00	1.00	Other	863	94
551	FIB.transitioning.motility_remodelling	2.99e-04	Nonsignificant	—	0.49	Other	0	0
552	T.CD8_Tem.TEMRA	2.88e-04	Nonsignificant	0.96	0.86	Other	920	1,088
553	NK.cytokine_biosynthetic_primed	2.84e-04	Nonsignificant	1.00	0.97	Other	360	21
554	SKM.type_1_slow.glycolytic	2.59e-04	Nonsignificant	0.25	1.12	Other	362	647
555	EPI.cervical_suprabasal.secretory_vesicle	2.43e-04	Nonsignificant	—	0.00	Other	0	0
556	EPI.thymic_cortical.secretory_remodeling	2.20e-04	Nonsignificant	—	1.00	Other	4	1
557	IPSC.stress	1.93e-04	Nonsignificant	1.00	0.89	Other	0	0
558	OLG.myelinating_mature	1.83e-04	Nonsignificant	0.59	1.03	Other	363	94
559	CM.sarcomere_actin_interface	1.78e-04	Nonsignificant	0.97	0.99	Other	450	78
560	NEU.INH_PVALB.chandelier	1.69e-04	Nonsignificant	0.44	1.16	Other	19	16
561	NEU.INH_VIP.regulatory_remodeling	1.52e-04	Nonsignificant	—	0.00	Other	6	1
562	FIB.skin_papillary.baseline	1.48e-04	Nonsignificant	—	0.00	Other	0	0
563	GRNLSA.p53_damage	1.45e-04	Nonsignificant	—	0.00	Other	13	10
564	NEU.INH_VIP.cannabinoid	1.38e-04	Nonsignificant	—	0.00	Other	0	0
565	NEU.INH_PVALB.nuclear_reg	1.37e-04	Nonsignificant	0.44	1.10	Other	25	12
566	NK.adaptive_terminal_cytotoxic	1.37e-04	Nonsignificant	1.00	0.90	Other	485	802
567	DC.pDC.immature_metabolic	1.35e-04	Nonsignificant	0.93	0.96	Other	78	124
568	CM.mito_proteostasis	1.25e-04	Nonsignificant	0.37	1.06	Other	329	29
569	MAC.alveolar.biosynthetic_sterol_heme	1.03e-04	Nonsignificant	0.79	1.12	Other	347	40
570	NEU.EXC_IT.adhesion	9.93e-05	Nonsignificant	1.00	0.73	Other	252	108
571	GRNLSA.secretory_remodeling	9.23e-05	Nonsignificant	0.97	0.65	Other	90	25
572	IPSC.canonical_pluripotent	8.89e-05	Nonsignificant	1.00	0.90	Other	0	0
573	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	8.09e-05	Nonsignificant	—	0.37	Other	0	0
574	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	8.07e-05	Nonsignificant	0.99	0.47	Other	33	34
575	EC.liver_sinusoidal.secretory_lipoprotein	7.87e-05	Nonsignificant	0.63	0.90	Other	120	70
576	EPI.skin_interfollicular_spinous.stress_oxidative	7.44e-05	Nonsignificant	—	0.00	Other	0	0
577	MAC.proliferating.stress	7.35e-05	Nonsignificant	—	0.00	Other	87	136
578	CM.inflammatory	6.90e-05	Nonsignificant	—	1.30	Other	0	0
579	CHOND.angiogenic	5.80e-05	Nonsignificant	—	0.70	Other	0	0
580	T.CD8_Tem.signaling_turnover	5.17e-05	Nonsignificant	0.96	0.94	Other	425	683
581	EPI.skin_follicular_keratinizing.root_infundibulum	5.16e-05	Nonsignificant	—	0.49	Other	0	0
582	IPSC.midbrain_primed	5.08e-05	Nonsignificant	1.00	0.71	Other	0	0
583	NEU.INH_VIP.opioid	4.75e-05	Nonsignificant	—	0.00	Other	50	9
584	CM.oxidative_phospho	4.67e-05	Nonsignificant	0.77	1.02	Other	266	792
585	EPI.tracheal_basal.activated_stress	4.62e-05	Nonsignificant	0.02	1.23	Other	32	0
586	FIB.transitioning.ISG_primed_interface	4.30e-05	Nonsignificant	—	0.00	Other	17	80
587	NEU.INH_LAMP5.exc_inh_balance	3.72e-05	Nonsignificant	—	0.80	Other	46	2
588	HEP.acute_phase.proliferative	3.61e-05	Nonsignificant	—	1.10	Other	4	6
589	NEU.EXC_NTNG1.nuclear_reg	3.56e-05	Nonsignificant	—	0.67	Other	0	0
590	IPSC.neuroendocrine_primed	3.41e-05	Nonsignificant	—	0.29	Other	0	0
591	EPI.pancreatic_ductal_progenitor.ADM_like	3.28e-05	Nonsignificant	—	1.07	Other	0	0
592	IPSC.proliferative	2.96e-05	Nonsignificant	1.00	0.59	Other	0	0
593	HEP.acute_phase.stress_secretory	2.72e-05	Nonsignificant	0.70	1.20	Other	26	3
594	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	2.45e-05	Nonsignificant	—	0.97	Other	0	0
595	NK.adaptive_axis_baseline	2.19e-05	Nonsignificant	1.00	0.90	Other	1,008	153
596	B.germinal_center.LZ_selection	1.95e-05	Nonsignificant	—	0.92	Other	0	0
597	EPI.pancreatic_ductal_progenitor.baseline	1.52e-05	Nonsignificant	0.40	1.07	Other	179	702
598	HEP.acute_phase.complement_antiviral	1.50e-05	Nonsignificant	0.80	1.05	Other	377	751
599	EPI.skin_sweat_duct_keratinocyte.repair	1.47e-05	Nonsignificant	—	0.19	Other	0	0
600	CHOND.activated_fibro_like	1.44e-05	Nonsignificant	1.00	0.77	Other	531	188
601	EPI.alveolar_type_2.stress_response	1.29e-05	Nonsignificant	1.00	0.50	Other	675	1,562
602	HEP.acute_phase.hypoxia_lipid	1.26e-05	Nonsignificant	—	1.48	Other	0	0
603	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.24e-05	Nonsignificant	—	0.87	Other	0	0
604	EPI.skin_appendage_keratinocyte.transit_amplifying	1.22e-05	Nonsignificant	—	0.00	Other	109	358
605	EPI.endocervical_secretory.secretory_translocon	1.19e-05	Nonsignificant	—	0.67	Other	0	0
606	EPI.salivary_serous_acinar.seromucous_like	1.17e-05	Nonsignificant	—	0.00	Other	0	0
607	EPI.esophageal_suprabasal.basal_transitional	1.12e-05	Nonsignificant	0.90	0.70	Other	44	67
608	NEU.EXC_IT.callosal	1.11e-05	Nonsignificant	1.00	0.70	Other	286	119
609	NEU.INH_PVALB.metabotropic	1.06e-05	Nonsignificant	—	0.41	Other	0	0
610	EPI.skin_sebaceous_duct_luminal.detox_repair	9.92e-06	Nonsignificant	0.85	0.68	Other	137	94
611	B.germinal_center.LZ_memory_precursor	9.59e-06	Nonsignificant	—	0.79	Other	0	0
612	T.CD8_Tem.motility_primed	9.59e-06	Nonsignificant	0.96	0.77	Other	269	4
613	EC.liver_sinusoidal.remodeling_lipotoxicity	9.01e-06	Nonsignificant	—	0.00	Other	90	58
614	EPI.skin_follicular_keratinizing.transit_amplifying	8.52e-06	Nonsignificant	—	0.00	Other	21	49
615	EC.liver_sinusoidal.inflammatory	7.58e-06	Nonsignificant	—	0.00	Other	223	154
616	GRNLSA.angiocrine_mechanosensory	7.56e-06	Nonsignificant	—	0.00	Other	0	0
617	HEP.acute_phase.baseline	7.53e-06	Nonsignificant	0.99	0.99	Other	946	19
618	CHOND.pro_inflammatory	7.23e-06	Nonsignificant	1.00	0.73	Other	181	351
619	NEU.EXC_NTNG1.synaptic	6.87e-06	Nonsignificant	—	0.00	Other	0	0
620	OLG.regulatory_activated	6.83e-06	Nonsignificant	0.59	1.09	Other	196	614
621	EPI.skin_interfollicular_spinous.proliferative	6.26e-06	Nonsignificant	—	0.00	Other	0	0
622	EPI.pancreatic_ductal_progenitor.ciliated_transport	6.13e-06	Nonsignificant	—	0.00	Other	105	368
623	NK.cytokine_tissue_activation	5.90e-06	Nonsignificant	1.00	0.92	Other	267	450
624	OLG.regulatory	5.84e-06	Nonsignificant	0.83	1.00	Other	353	73
625	CM.translation_boost_RPL	5.62e-06	Nonsignificant	1.00	0.91	Other	129	1
626	NEU.EXC_SYT2.synaptic	5.33e-06	Nonsignificant	—	0.48	Other	0	0
627	EPI.esophageal_basal.junctional_barrier	5.31e-06	Nonsignificant	—	0.00	Other	0	0
628	EPI.skin_follicular_keratinizing.upper_infundibulum	4.95e-06	Nonsignificant	—	0.20	Other	8	2
629	EPI.skin_interfollicular_spinous.transition_basal	4.86e-06	Nonsignificant	1.00	0.28	Other	100	127
630	HEP.periportal_metabolic.inflammatory_activated	4.29e-06	Nonsignificant	1.00	0.63	Other	712	1,610
631	CM.mechano_activated	3.92e-06	Nonsignificant	1.00	0.91	Other	205	134
632	EC.liver_sinusoidal.stress	3.76e-06	Nonsignificant	—	0.00	Other	413	158
633	EPI.salivary_mucous_acinar.baseline	3.33e-06	Nonsignificant	—	—	Other	394	683
634	MAC.alveolar.inflammatory	2.99e-06	Nonsignificant	0.83	0.71	Other	208	312
635	NEU.INH_LAMP5.glial_interface	2.99e-06	Nonsignificant	—	0.00	Other	0	0
636	NEU.INH_PVALB.fastspike	2.85e-06	Nonsignificant	—	0.00	Other	24	22
637	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	2.74e-06	Nonsignificant	—	0.09	Other	0	0
638	EPI.ectocervical_granular.immune_interact	2.55e-06	Nonsignificant	—	0.00	Other	0	0
639	MAC.alveolar.capillary_interacting	2.25e-06	Nonsignificant	0.79	0.90	Other	113	181
640	EPI.skin_keratinocyte_basal.spinous_transition	1.96e-06	Nonsignificant	—	0.97	Other	0	0
641	CM.translation_boost_RPS	1.68e-06	Nonsignificant	0.97	0.98	Other	69	16
642	DC.pDC.baseline	1.64e-06	Nonsignificant	0.93	0.72	Other	88	123
643	MAC.alveolar.lipid_autophagy	1.62e-06	Nonsignificant	—	0.00	Other	35	44
644	EPI.skin_sweat_duct_keratinocyte.proliferative_S	1.41e-06	Nonsignificant	—	0.00	Other	0	0
645	B.germinal_center.DZ_M_phase	1.38e-06	Nonsignificant	—	0.00	Other	0	0
646	NEU.EXC_IT.guidance	1.37e-06	Nonsignificant	1.00	0.50	Other	274	63
647	NEU.EXC_CT.Ca2_signaling	1.14e-06	Nonsignificant	—	0.00	Other	68	17
648	EPI.skin_hair_follicle_companion.activated_migratory	1.08e-06	Nonsignificant	—	0.00	Other	0	0
649	EPI.esophageal_suprabasal.proliferative_S	1.01e-06	Nonsignificant	—	0.00	Other	26	41
650	HEP.periportal_metabolic.acute_phase_barrier	9.80e-07	Nonsignificant	1.00	0.66	Other	533	138
651	NK.adaptive_adipose_stress	9.33e-07	Nonsignificant	1.00	0.71	Other	374	39
652	SKM.type_1_slow.oxidative	7.10e-07	Nonsignificant	0.98	0.92	Other	802	251
653	NEU.INH_PVALB.neuromodulatory	6.88e-07	Nonsignificant	—	0.00	Other	0	0
654	EPI.skin_sweat_duct_keratinocyte.signal_gate	6.51e-07	Nonsignificant	—	0.00	Other	43	26
655	SKM.type_1_slow.contractile	6.28e-07	Nonsignificant	0.98	0.83	Other	596	8
656	NEU.INH_PVALB.serotonergic	5.78e-07	Nonsignificant	—	0.00	Other	0	0
657	B.germinal_center.DZ_S_phase	5.37e-07	Nonsignificant	—	0.00	Other	0	0
658	NEU.INH_LAMP5.projecting	4.89e-07	Nonsignificant	—	0.00	Other	0	0
659	OLG.reactive_repair	4.85e-07	Nonsignificant	0.83	0.94	Other	385	385
660	HEP.acute_phase.inflammatory	4.46e-07	Nonsignificant	0.99	0.96	Other	382	649
661	B.germinal_center.LZ_survival	3.84e-07	Nonsignificant	—	0.00	Other	0	0
662	NEU.EXC_CT.Ca2_sensor	3.40e-07	Nonsignificant	—	0.00	Other	0	0
663	OLG.myelinating_stress	2.50e-07	Nonsignificant	0.83	0.99	Other	232	62
664	EPI.tracheal_basal.homeostatic_progenitor	2.37e-07	Nonsignificant	1.00	0.00	Other	285	74
665	EPI.endocervical_secretory.squamous_barrier	2.30e-07	Nonsignificant	—	0.00	Other	0	0
666	MAC.alveolar.scavenging_endocytic	1.96e-07	Nonsignificant	—	0.00	Other	140	283
667	CM.anti_inflammatory	1.40e-07	Nonsignificant	1.00	0.83	Other	424	1,503
668	NK.adaptive_biosynthetic_primed	1.14e-07	Nonsignificant	1.00	0.72	Other	244	405
669	EPI.skin_keratinocyte_basal.transit_amplifying	6.76e-08	Nonsignificant	—	0.00	Other	0	0
670	OLG.vesicle_trafficking	4.39e-08	Nonsignificant	0.83	0.89	Other	124	10
671	EPI.skin_hair_follicle_companion.gap_junction_contractile	3.44e-08	Nonsignificant	—	0.00	Other	0	0
672	EPI.esophageal_suprabasal.proliferative_exit	3.08e-08	Nonsignificant	—	0.00	Other	0	0
673	EPI.esophageal_suprabasal.proliferative_G2M	1.90e-08	Nonsignificant	—	0.00	Other	0	0
674	NEU.INH_LAMP5.rosehip	1.83e-08	Nonsignificant	—	0.00	Other	0	0
675	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.57e-08	Nonsignificant	—	0.00	Other	39	82
676	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.07e-08	Nonsignificant	—	0.87	Other	135	290
677	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	5.85e-09	Nonsignificant	—	0.00	Other	0	0
678	EPI.skin_keratinocyte_basal.basement_anchoring	5.64e-09	Nonsignificant	—	0.00	Other	0	0
679	EPI.skin_sebaceous_duct_luminal.immune_interface	1.73e-09	Nonsignificant	—	0.00	Other	0	0
680	NEU.EXC_SYT2.nuclear_reg	1.35e-09	Nonsignificant	—	0.00	Other	0	0
681	EPI.thymic_cortical.baseline	1.18e-09	Nonsignificant	0.82	0.59	Other	185	386
682	EPI.thymic_cortical.Notch_interface	9.79e-10	Nonsignificant	—	0.00	Other	82	137
683	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	6.52e-10	Nonsignificant	—	0.00	Other	0	0
684	EPI.tracheal_suprabasal.transitional_wound	4.05e-10	Nonsignificant	—	0.00	Other	16	1
685	EPI.skin_keratinocyte_proliferating.anchor_remodel	2.48e-10	Nonsignificant	—	0.00	Other	0	0
686	EPI.ectocervical_granular.proliferative_basal	4.76e-11	Nonsignificant	—	0.00	Other	0	0
687	HEP.acute_phase.complement_metabolic	2.89e-12	Nonsignificant	1.00	0.40	Other	1,423	3,464
688	EPI.skin_keratinocyte_proliferating.detox_repair	9.22e-15	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

0 unique genes. Showing 0–0. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.