Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000084 · All tissues

Anaphylactic shock due to adverse effect of correct drug or medication properly administered: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Drug hypersensitivity

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte	13.28	Significant	1.65e-49	1.35	Specific	385	1,507
2	natural_killer_cell	11.77	Significant	1.65e-49	1.34	Specific	1,204	2,052
3	schwann_cell	2.34	Nonsignificant	1.00	1.01	Other	10	57
4	hepatocyte	1.87	Nonsignificant	6.50e-05	1.11	Other	1,515	3,822
5	haematopoietic_progenitor_cell	1.84	Nonsignificant	1.00	0.95	Other	262	502
6	thymocyte	1.71	Nonsignificant	1.00	0.96	Other	168	512
7	induced_pluripotent_stem_cell	1.61	Nonsignificant	1.00	0.98	Other	0	0
8	adipose_stem_and_progenitor_cell	1.50	Nonsignificant	1.00	0.93	Other	327	954
9	B_cell	1.42	Nonsignificant	1.00	0.95	Other	356	694
10	T_cell	1.01	Nonsignificant	1.00	0.81	Other	470	959
11	innate_lymphoid_cell_2	0.83	Nonsignificant	1.00	0.97	Other	3	8
12	fibroblast	0.83	Nonsignificant	1.00	0.79	Other	184	826
13	neuron	0.76	Nonsignificant	1.00	0.85	Other	330	1,328
14	dendritic_cell	0.59	Nonsignificant	1.00	0.99	Other	496	724
15	epithelial_cell	0.51	Nonsignificant	1.00	0.73	Other	24	47
16	plasma_cell	0.34	Nonsignificant	1.00	0.57	Other	17	24
17	platelet	0.28	Nonsignificant	—	0.00	Other	85	104
18	muscle_stem_cell	0.27	Nonsignificant	1.00	0.60	Other	7	27
19	mesothelial_cell	0.26	Nonsignificant	1.00	0.67	Other	6	36
20	endothelial_cell	0.21	Nonsignificant	1.00	0.48	Other	373	974
21	granulocyte	0.19	Nonsignificant	1.00	0.64	Other	5	6
22	monocyte	0.17	Nonsignificant	1.00	0.48	Other	2,176	3,871
23	oligodendrocyte_precursor_cell	0.16	Nonsignificant	1.00	0.44	Other	461	1,454
24	smooth_muscle_cell	0.09	Nonsignificant	1.00	0.42	Other	27	139
25	adipocyte	0.06	Nonsignificant	1.00	0.46	Other	33	111
26	pericyte	0.04	Nonsignificant	1.00	0.32	Other	128	517
27	macrophage	0.02	Nonsignificant	1.00	0.38	Other	813	1,732
28	microglia	0.02	Nonsignificant	1.00	0.56	Other	61	129
29	astrocyte	0.01	Nonsignificant	1.00	0.40	Other	256	1,203
30	melanocyte	0.01	Nonsignificant	1.00	0.35	Other	97	309
31	granulosa_cell	9.93e-03	Nonsignificant	1.00	0.29	Other	293	670
32	chondrocyte	1.64e-03	Nonsignificant	1.00	0.22	Other	548	1,069
33	skeletal_muscle_cell	1.28e-03	Nonsignificant	1.00	0.21	Other	944	2,600
34	cardiomyocyte	9.32e-04	Nonsignificant	1.00	0.37	Other	533	2,045

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OLG.oligodendrocyte	13.28	Significant	—	—	Specific	384	1,397
2	NK.natural_killer_cell	11.77	Significant	—	—	Specific	1,204	2,045
3	NEU.INH_LAMP5	8.56	Significant	5.78e-14	1.39	Specific	263	532
4	T.CD8_Tem	6.49	Significant	1.60e-49	1.54	Specific	1,083	1,857
5	HEP.canalicular_transport	4.67	Nominal	1.02e-41	1.46	Other	1,290	3,434
6	EPI.pancreatic_islet	4.62	Nominal	0.06	1.39	Other	52	132
7	DC.cDC1	3.54	Nominal	0.04	1.22	Other	55	112
8	FIB.barrier_secretory	3.02	Nominal	7.87e-03	1.72	Other	81	228
9	SCHWN.schwann_cell	2.34	Nonsignificant	—	—	Other	7	33
10	B.age_associated	2.25	Nonsignificant	0.18	1.45	Other	207	350
11	EPI.cervical_suprabasal	2.14	Nonsignificant	—	1.58	Other	14	50
12	HPC.haematopoietic_progenitor_cell	1.84	Nonsignificant	—	—	Other	211	370
13	FIB.neurolectin_mucosa	1.80	Nonsignificant	2.04e-06	1.93	Other	133	394
14	T.CD4_cytotoxic	1.76	Nonsignificant	0.60	1.14	Other	855	1,493
15	THYMO.thymocyte	1.71	Nonsignificant	—	—	Other	163	495
16	EPI.tracheal_basal	1.66	Nonsignificant	0.09	1.30	Other	398	1,120
17	IPSC.induced_pluripotent_stem_cell	1.61	Nonsignificant	—	—	Other	0	0
18	EPI.salivary_intercalated_defense	1.58	Nonsignificant	0.22	1.22	Other	81	161
19	EPI.salivary_duct_excretory	1.54	Nonsignificant	0.22	1.24	Other	85	180
20	ASPC.adipose_stem_and_progenitor_cell	1.50	Nonsignificant	—	—	Other	324	930
21	FIB.transitioning	1.49	Nonsignificant	7.87e-03	1.65	Other	172	497
22	B.naive	1.43	Nonsignificant	0.73	1.04	Other	307	595
23	DC.pDC	1.40	Nonsignificant	0.12	1.11	Other	496	1,028
24	B.memory	1.36	Nonsignificant	0.79	0.93	Other	442	882
25	EPI.skin_sebaceous_duct_luminal	1.28	Nonsignificant	0.22	1.25	Other	100	249
26	EPI.skin_keratinocyte_progenitor	1.25	Nonsignificant	—	1.14	Other	0	3
27	B.germinal_center	1.20	Nonsignificant	0.79	0.75	Other	233	655
28	FIB.interstitial	1.19	Nonsignificant	4.27e-06	1.49	Other	288	940
29	EPI.salivary_myoepithelial	1.17	Nonsignificant	0.22	1.17	Other	191	714
30	T.CD8_naive	1.15	Nonsignificant	0.60	1.05	Other	317	708
31	EPI.renal_intercalated_cell_type_A	1.14	Nonsignificant	1.00	1.07	Other	67	142
32	EPI.colonic_enteroendocrine	1.12	Nonsignificant	—	0.74	Other	1	1
33	EPI.skin_sweat_duct_keratinocyte	1.11	Nonsignificant	0.75	1.13	Other	146	301
34	FIB.tracheal_subepithelial	1.09	Nonsignificant	—	0.61	Other	0	0
35	EPI.pancreatic_acinar	0.97	Nonsignificant	9.68e-04	1.27	Other	429	1,475
36	FIB.barrier_purinergic	0.91	Nonsignificant	—	0.29	Other	1	3
37	EPI.skin_hair_follicle_companion	0.90	Nonsignificant	—	0.89	Other	8	12
38	EPI.skin_interfollicular_spinous	0.89	Nonsignificant	0.22	1.17	Other	260	563
39	ILC2.innate_lymphoid_cell_2	0.83	Nonsignificant	—	—	Other	2	0
40	T.CD4_Treg	0.82	Nonsignificant	1.00	0.97	Other	244	511
41	NEU.EXC_NTNG1	0.81	Nonsignificant	—	0.81	Other	0	0
42	EPI.salivary_duct_ion_transport	0.81	Nonsignificant	1.00	1.13	Other	5	11
43	EPI.renal_intercalated_cell_type_B	0.80	Nonsignificant	—	0.84	Other	6	7
44	NEU.INH_PVALB	0.79	Nonsignificant	0.39	1.10	Other	193	183
45	FIB.lung_alveolar	0.72	Nonsignificant	—	0.17	Other	6	15
46	T.CD4_Th2	0.69	Nonsignificant	—	0.34	Other	1	2
47	EPI.salivary_serous_acinar	0.67	Nonsignificant	1.00	1.00	Other	233	531
48	EPI.colonic_tuft	0.67	Nonsignificant	—	0.66	Other	7	24
49	FIB.skin_papillary	0.66	Nonsignificant	—	0.16	Other	0	0
50	T.CD8_transitional	0.63	Nonsignificant	1.00	0.90	Other	497	932
51	HEP.acute_phase	0.56	Nonsignificant	1.00	0.87	Other	1,441	3,641
52	EPI.esophageal_basal	0.56	Nonsignificant	1.00	0.96	Other	4	10
53	FIB.skin_tenogenic	0.56	Nonsignificant	—	0.00	Other	108	227
54	FIB.adventitial	0.55	Nonsignificant	1.00	0.24	Other	268	1,447
55	EPI.tracheal_suprabasal	0.54	Nonsignificant	1.00	1.02	Other	29	56
56	FIB.reticular	0.53	Nonsignificant	1.00	0.51	Other	19	87
57	FIB.skin_neurosecretory	0.52	Nonsignificant	—	0.00	Other	0	0
58	EPI.esophageal_suprabasal	0.51	Nonsignificant	1.00	0.94	Other	158	404
59	EPI.thymic_cortical	0.49	Nonsignificant	1.00	1.05	Other	442	824
60	T.CD8_Trm	0.48	Nonsignificant	1.00	0.75	Other	211	346
61	PC.IgG_systemic	0.47	Nonsignificant	0.05	1.41	Other	41	60
62	EPI.renal_thick_ascending_limb	0.47	Nonsignificant	1.00	0.95	Other	453	1,153
63	T.gamma_delta	0.46	Nonsignificant	0.60	1.09	Other	588	1,078
64	T.CD4_naive	0.42	Nonsignificant	1.00	0.72	Other	399	866
65	DC.mig	0.40	Nonsignificant	—	0.70	Other	89	156
66	EPI.skin_follicular_keratinizing	0.36	Nonsignificant	1.00	0.89	Other	30	81
67	EPI.tracheal_submucosal_gland	0.33	Nonsignificant	—	0.39	Other	0	0
68	T.CD4_Tfh	0.32	Nonsignificant	1.00	0.59	Other	47	45
69	PC.IgA_muocsal	0.32	Nonsignificant	1.00	0.45	Other	18	31
70	EC.arterial	0.31	Nonsignificant	0.08	1.15	Other	356	885
71	EC.venous	0.31	Nonsignificant	0.16	1.11	Other	516	1,387
72	GRANU.MAST	0.29	Nonsignificant	9.43e-04	1.62	Other	5	6
73	EPI.lung_club_secretory	0.28	Nonsignificant	1.00	0.85	Other	5	14
74	EPI.renal_distal_tubule	0.28	Nonsignificant	1.00	0.84	Other	133	361
75	PLAT.platelet	0.28	Nonsignificant	—	0.00	Other	38	53
76	EPI.renal_proximal_tubule	0.27	Nonsignificant	1.00	0.88	Other	525	806
77	NEU.EXC_IT	0.27	Nonsignificant	1.00	0.75	Other	411	192
78	MUSC.muscle_stem_cell	0.27	Nonsignificant	—	—	Other	4	18
79	MESO.mesothelial_cell	0.26	Nonsignificant	—	—	Other	2	18
80	T.CD8_Tcm	0.25	Nonsignificant	1.00	0.58	Other	460	926
81	FIB.skin_sheath	0.25	Nonsignificant	1.00	0.26	Other	49	118
82	NEU.INH_VIP	0.25	Nonsignificant	0.30	1.14	Other	241	366
83	FIB.perivascular_interface	0.23	Nonsignificant	1.00	0.23	Other	0	0
84	T.CD4_Tem	0.21	Nonsignificant	1.00	0.70	Other	365	697
85	MAC.kupffer	0.21	Nonsignificant	0.58	1.09	Other	189	530
86	EPI.ileal_bile_transport	0.20	Nonsignificant	1.00	0.70	Other	61	93
87	MONO.CD14	0.17	Nonsignificant	2.67e-03	1.24	Other	2,294	4,139
88	DC.cDC2	0.16	Nonsignificant	1.00	0.77	Other	1,189	1,793
89	EC.capillary	0.16	Nonsignificant	1.00	0.91	Other	514	1,635
90	OPC.oligodendrocyte_precursor_cell	0.16	Nonsignificant	—	—	Other	413	1,269
91	EPI.skin_keratinocyte_proliferating	0.15	Nonsignificant	1.00	0.56	Other	47	76
92	T.CD4_Trm	0.14	Nonsignificant	1.00	0.44	Other	176	363
93	T.CD4_transitional	0.13	Nonsignificant	1.00	0.40	Other	48	110
94	EPI.colonocyte	0.13	Nonsignificant	1.00	0.66	Other	294	815
95	MONO.CD16	0.12	Nonsignificant	1.00	0.68	Other	1,304	1,835
96	EPI.pancreatic_ductal_progenitor	0.11	Nonsignificant	1.00	0.57	Other	234	873
97	EPI.ileal_enterocyte_absorptive	0.10	Nonsignificant	1.00	0.70	Other	118	338
98	T.CD4_Tcm	0.09	Nonsignificant	1.00	0.29	Other	494	988
99	EPI.skin_hair_follicle_bulge	0.09	Nonsignificant	1.00	0.50	Other	51	178
100	EC.liver_sinusoidal	0.09	Nonsignificant	1.00	0.82	Other	1,083	1,925
101	EPI.skin_keratinocyte_basal	0.09	Nonsignificant	—	0.00	Other	13	26
102	SMC.smooth_muscle_cell	0.09	Nonsignificant	—	—	Other	20	101
103	EPI.renal_immature_ureteric_bud	0.09	Nonsignificant	1.00	0.51	Other	217	569
104	EPI.renal_principal_cell	0.06	Nonsignificant	1.00	0.47	Other	207	403
105	MAC.resident_iron	0.06	Nonsignificant	0.58	1.07	Other	16	21
106	ADIPO.adipocyte	0.06	Nonsignificant	—	—	Other	20	62
107	EPI.pancreatic_ductal_bicarbonate	0.06	Nonsignificant	0.22	1.14	Other	131	548
108	EPI.skin_appendage_keratinocyte	0.06	Nonsignificant	1.00	0.49	Other	87	222
109	EPI.thymic_medullary	0.05	Nonsignificant	1.00	0.48	Other	26	133
110	EPI.pancreatic_ductal_perivascular	0.05	Nonsignificant	1.00	0.53	Other	4	30
111	EPI.gastric_foveolar	0.05	Nonsignificant	—	0.00	Other	0	0
112	T.CD4_Th17	0.04	Nonsignificant	1.00	0.52	Other	421	794
113	EPI.ileal_enterocyte_crypt	0.04	Nonsignificant	1.00	0.51	Other	67	113
114	PERI.pericyte	0.04	Nonsignificant	—	—	Other	117	0
115	MAC.microglia_like	0.04	Nonsignificant	0.81	1.07	Other	124	179
116	FIB.suburothelial	0.04	Nonsignificant	1.00	0.03	Other	122	432
117	EPI.ectocervical_granular	0.03	Nonsignificant	—	0.00	Other	11	23
118	HEP.periportal_metabolic	0.03	Nonsignificant	1.00	0.27	Other	1,750	4,427
119	EPI.alveolar_type_1	0.02	Nonsignificant	1.00	0.37	Other	26	101
120	FIB.hepatic_stellate_cell	0.02	Nonsignificant	—	0.00	Other	64	252
121	NEU.EXC_CT	0.02	Nonsignificant	1.00	0.49	Other	362	384
122	MG.microglia	0.02	Nonsignificant	—	—	Other	49	0
123	EPI.bile_duct_cholangiocyte	0.02	Nonsignificant	1.00	0.39	Other	37	60
124	ASTRO.astrocyte	0.01	Nonsignificant	—	—	Other	228	1,111
125	HEP.pericentral_lipoprotein	0.01	Nonsignificant	—	0.00	Other	0	0
126	MEL.melanocyte	0.01	Nonsignificant	—	—	Other	79	242
127	NEU.EXC_SYT2	0.01	Nonsignificant	—	0.00	Other	40	77
128	MAC.resident_repair	0.01	Nonsignificant	1.00	0.97	Other	796	1,426
129	GRNLSA.granulosa_cell	9.93e-03	Nonsignificant	—	—	Other	257	0
130	MAC.MDM	9.36e-03	Nonsignificant	0.58	1.03	Other	623	986
131	MAC.proliferating	8.96e-03	Nonsignificant	0.58	1.13	Other	87	253
132	EC.lymphatic	8.35e-03	Nonsignificant	1.00	0.23	Other	630	998
133	EC.heart_remodeling	7.07e-03	Nonsignificant	1.00	0.41	Other	569	1,594
134	MAC.LAM	6.32e-03	Nonsignificant	1.00	0.92	Other	914	2,064
135	EPI.endocervical_secretory	6.28e-03	Nonsignificant	—	0.00	Other	0	0
136	T.MAIT	3.49e-03	Nonsignificant	1.00	0.10	Other	469	855
137	EPI.alveolar_type_2	3.32e-03	Nonsignificant	1.00	0.68	Other	813	1,853
138	SKM.type_2_fast	2.18e-03	Nonsignificant	5.33e-15	1.48	Other	972	2,639
139	MAC.resident_cardiac	1.83e-03	Nonsignificant	1.00	0.89	Other	485	1,074
140	CHOND.chondrocyte	1.64e-03	Nonsignificant	—	—	Other	519	730
141	EPI.ileal_goblet	1.58e-03	Nonsignificant	1.00	0.32	Other	181	432
142	CM.cardiomyocyte	9.32e-04	Nonsignificant	—	—	Other	524	2,032
143	EPI.pancreatic_ductal_mucinous	3.08e-04	Nonsignificant	1.00	0.30	Other	219	430
144	GRANU.neutrophil	1.78e-04	Nonsignificant	1.00	0.00	Other	1,235	2,649
145	EPI.extrahepatic_cholangiocyte	6.83e-05	Nonsignificant	—	0.00	Other	37	71
146	SKM.type_1_slow	6.24e-05	Nonsignificant	1.00	0.43	Other	923	2,478
147	EPI.intrahepatic_cholangiocyte_defense	2.09e-05	Nonsignificant	—	0.00	Other	8	13
148	EPI.hepatic_ductular_cholangiocyte	1.11e-05	Nonsignificant	1.00	0.22	Other	83	243
149	EPI.lung_multiciliated	1.00e-05	Nonsignificant	1.00	0.13	Other	16	49
150	EPI.salivary_mucous_acinar	6.33e-06	Nonsignificant	1.00	0.13	Other	639	1,189
151	EPI.intrahepatic_cholangiocyte_transport	3.21e-06	Nonsignificant	—	0.00	Other	12	42
152	MAC.alveolar	1.61e-06	Nonsignificant	1.00	0.33	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OLG.myelinating_mature	16.21	Significant	1.44e-08	2.45	—	363	94
2	OLG.myelinating_stress	15.67	Significant	0.01	1.86	—	232	62
3	NK.cytokine_axis_baseline	14.91	Significant	2.92e-10	2.18	—	1,172	116
4	NK.cytokine_biosynthetic_primed	14.29	Significant	0.03	1.70	—	360	21
5	OLG.vesicle_trafficking	14.15	Significant	0.62	1.21	—	124	10
6	NK.cytokine_vascular_patrolling	14.01	Significant	8.62e-04	1.85	—	863	94
7	NK.cytokine_repair_primed	13.81	Significant	0.06	1.64	—	266	11
8	NK.cytokine_quiescent	13.76	Significant	0.39	1.31	Specific	623	1,062
9	OLG.regulatory_activated	12.59	Significant	1.00	0.64	Relevant	196	614
10	NK.adaptive_HLAE_tuned	12.17	Significant	0.75	1.13	—	1,124	189
11	NK.adaptive_biosynthetic_primed	12.04	Significant	1.00	0.90	Relevant	244	405
12	OLG.stress	11.25	Significant	1.00	0.32	—	232	8
13	NK.adaptive_axis_baseline	11.17	Significant	1.00	0.99	—	1,008	153
14	NK.adaptive_classII_inhibitory	10.96	Significant	1.00	0.69	—	880	154
15	OLG.regulatory	10.63	Significant	1.00	0.08	—	353	73
16	NEU.INH_LAMP5.glial_interface	9.84	Significant	—	1.16	Relevant	0	0
17	NK.cytokine_tissue_activation	9.69	Significant	1.00	0.49	Relevant	267	450
18	OLG.reactive_repair	9.36	Significant	1.00	0.16	—	385	385
19	NEU.INH_LAMP5.rosehip	9.36	Significant	—	0.71	Relevant	0	0
20	NK.adaptive_adipose_stress	9.09	Significant	1.00	0.39	—	374	39
21	NEU.INH_LAMP5.exc_inh_balance	8.01	Significant	—	0.00	—	46	2
22	HEP.canalicular_transport.ductular_like_transition	7.72	Significant	2.50e-03	1.54	Specific	400	87
23	NEU.INH_LAMP5.projecting	7.68	Significant	—	0.00	—	0	0
24	T.CD8_Tem.signaling_turnover	7.57	Significant	0.29	1.47	Relevant	425	683
25	NK.cytokine_lung_immediate_early	7.48	Significant	1.00	0.12	—	424	274
26	T.CD8_Tem.TEMRA	7.32	Significant	0.84	1.04	Specific	920	1,088
27	T.CD8_Tem.motility_primed	7.30	Significant	0.88	0.92	—	269	4
28	T.CD8_Tem.stress_adapted	6.78	Significant	0.84	1.05	Specific	607	520
29	ASPC.signal_integrator	6.59	Significant	—	1.46	Other	0	0
30	HEP.canalicular_transport.pericentral_like_hypoxia	6.32	Significant	4.67e-03	1.51	Other	326	8
31	NK.immature_bridge	6.25	Significant	1.00	0.16	—	117	122
32	NK.adaptive_immature_precursor	6.14	Significant	1.00	0.11	—	358	111
33	T.CD8_Tem.baseline	5.72	Significant	0.95	0.65	Other	458	356
34	EPI.pancreatic_islet.beta	5.61	Significant	0.34	1.23	Other	42	57
35	HEP.canalicular_transport.secretory_ERAD_UPR	5.45	Nominal	0.99	0.90	Other	232	28
36	T.CD8_Tem.early_helper_like	5.24	Nominal	0.95	0.72	Other	445	755
37	EPI.salivary_serous_acinar.quiescent	5.21	Nominal	3.61e-08	1.72	Other	178	493
38	NK.cytokine_tissue_resident	5.08	Nominal	1.00	0.12	Other	74	82
39	HEP.canalicular_transport.baseline	4.73	Nominal	0.68	1.09	Other	199	477
40	HEP.canalicular_transport.injury_stress	4.51	Nominal	0.99	0.85	Other	289	24
41	EPI.pancreatic_islet.alpha	4.23	Nominal	—	0.00	Other	152	330
42	IPSC.mesendo_primed	4.17	Nominal	1.08e-11	1.50	Other	0	0
43	ASPC.remodeling	4.01	Nominal	1.99e-08	2.07	Other	106	354
44	DC.cDC1.cross_presenting	3.91	Nominal	—	0.52	Other	0	0
45	DC.cDC1.activated	3.88	Nominal	—	0.52	Other	0	0
46	EPI.skin_sweat_duct_keratinocyte.barrier	3.84	Nominal	—	1.52	Other	0	0
47	HPC.GMP_inflammatory	3.72	Nominal	0.35	1.41	Other	20	10
48	DC.cDC1.baseline	3.65	Nominal	—	0.49	Other	0	0
49	DC.cDC1.proliferative	3.14	Nominal	—	0.00	Other	0	0
50	FIB.barrier_secretory.remodeling	3.14	Nominal	—	0.26	Other	0	0
51	ASPC.mesothelial_like	3.09	Nominal	0.19	1.54	Other	143	486
52	NK.adaptive_terminal_cytotoxic	3.01	Nominal	1.00	0.00	Other	485	802
53	B.memory.pDC_imprint	3.00	Nominal	0.01	1.79	Other	157	103
54	IPSC.stromal_primed	2.99	Nonsignificant	0.03	1.21	Other	0	0
55	FIB.barrier_secretory.homeostasis	2.94	Nonsignificant	—	0.00	Other	0	0
56	THYMO.DP_early	2.90	Nonsignificant	1.38e-08	2.06	Other	326	313
57	DC.cDC1.homeostatic_inhibitory	2.88	Nonsignificant	—	0.00	Other	0	0
58	SCHWN.translation_boost	2.84	Nonsignificant	—	0.00	Other	8	1
59	HEP.canalicular_transport.inflammatory	2.80	Nonsignificant	1.00	0.47	Other	1,335	194
60	EPI.pancreatic_acinar.quiet_dedifferentiation	2.79	Nonsignificant	0.49	1.19	Other	142	171
61	B.age_associated.activated	2.76	Nonsignificant	—	0.49	Other	18	22
62	T.CD4_cytotoxic.NK_adapted	2.57	Nonsignificant	0.98	1.07	Other	82	33
63	HPC.GMP_granulocytic	2.48	Nonsignificant	—	0.40	Other	3	3
64	SCHWN.axon_contact_cardiac	2.47	Nonsignificant	0.04	1.74	Other	18	63
65	HEP.acute_phase.hypoxia_lipid	2.45	Nonsignificant	—	2.64	Other	0	0
66	ASPC.stem_like_progenitor	2.39	Nonsignificant	4.81e-03	1.64	Other	300	842
67	EPI.cervical_suprabasal.secretory_vesicle	2.38	Nonsignificant	—	0.42	Other	0	0
68	EPI.pancreatic_acinar.stress	2.37	Nonsignificant	0.70	1.05	Other	28	28
69	EPI.colonic_enteroendocrine.Lcell_peptide	2.32	Nonsignificant	—	0.97	Other	0	0
70	T.CD4_cytotoxic.terminal_effector	2.31	Nonsignificant	0.08	1.43	Other	286	21
71	HPC.MPP_IEG	2.29	Nonsignificant	0.95	0.97	Other	45	46
72	B.age_associated.migratory	2.15	Nonsignificant	0.81	0.67	Other	2	2
73	IPSC.axial_identity_primed	2.12	Nonsignificant	0.47	1.07	Other	0	0
74	B.naive.receptor_recycle	2.10	Nonsignificant	0.20	1.43	Other	51	0
75	THYMO.SP_CD4_naive	2.06	Nonsignificant	0.78	1.12	Other	65	75
76	ASPC.adipocyte_capillary_interface	2.03	Nonsignificant	0.50	1.21	Other	21	54
77	FIB.interstitial.lipid_matrix	2.02	Nonsignificant	3.41e-08	2.23	Other	258	191
78	FIB.transitioning.matrix_stress	1.95	Nonsignificant	—	0.34	Other	47	138
79	EPI.cervical_suprabasal.inflammatory_repair	1.89	Nonsignificant	—	0.00	Other	0	0
80	FIB.neurolectin_mucosa.axon_responsive	1.89	Nonsignificant	0.42	1.31	Other	10	10
81	ASPC.proliferative	1.88	Nonsignificant	0.50	1.23	Other	33	85
82	FIB.neurolectin_mucosa.inflammatory	1.83	Nonsignificant	0.42	1.07	Other	52	110
83	B.naive.remodeling	1.82	Nonsignificant	0.20	1.29	Other	135	230
84	FIB.neurolectin_mucosa.remodeling_repair	1.82	Nonsignificant	—	0.22	Other	4	2
85	EPI.salivary_intercalated_defense.canonical_antimicrobial	1.75	Nonsignificant	0.20	1.56	Other	11	22
86	DC.pDC.baseline	1.74	Nonsignificant	0.85	0.96	Other	88	123
87	ASPC.baseline	1.71	Nonsignificant	0.56	1.04	Other	363	170
88	DC.pDC.immature_metabolic	1.71	Nonsignificant	0.27	1.36	Other	78	124
89	B.naive.purinergic	1.71	Nonsignificant	0.20	1.24	Other	384	820
90	EPI.tracheal_basal.homeostatic_progenitor	1.70	Nonsignificant	0.72	0.88	Other	285	74
91	T.CD8_transitional.effector_primed	1.67	Nonsignificant	3.94e-06	1.38	Other	435	151
92	THYMO.CD8aa_IELp	1.67	Nonsignificant	—	0.11	Other	1	7
93	THYMO.SP_CD8_naive	1.64	Nonsignificant	0.78	1.09	Other	297	177
94	ASPC.secretory	1.64	Nonsignificant	0.56	1.04	Other	76	5
95	FIB.interstitial.stress_secretory	1.62	Nonsignificant	0.69	1.28	Other	92	56
96	EPI.tracheal_basal.activated_stress	1.61	Nonsignificant	0.72	0.67	Other	32	0
97	FIB.neurolectin_mucosa.nerve_interface	1.61	Nonsignificant	—	0.00	Other	4	0
98	ASPC.niche_keeping_progenitor	1.60	Nonsignificant	0.50	1.12	Other	52	219
99	B.age_associated.naive_transitional	1.59	Nonsignificant	—	0.00	Other	0	0
100	B.naive.metabolic	1.56	Nonsignificant	0.73	0.95	Other	50	79
101	EPI.salivary_duct_excretory.baseline	1.56	Nonsignificant	0.63	0.80	Other	23	57
102	B.memory.baseline	1.55	Nonsignificant	0.02	1.43	Other	472	99
103	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.54	Nonsignificant	—	0.32	Other	0	0
104	B.germinal_center.LZ_survival	1.54	Nonsignificant	—	1.47	Other	0	0
105	B.naive.antigen_presenting_ready	1.51	Nonsignificant	0.73	1.02	Other	48	73
106	NEU.INH_VIP.LAMP5_hybrid	1.51	Nonsignificant	—	1.55	Other	1	9
107	B.naive.proteostasis	1.50	Nonsignificant	0.73	1.02	Other	49	69
108	EPI.salivary_duct_excretory.stress	1.49	Nonsignificant	0.63	0.81	Other	33	68
109	B.naive.baseline	1.49	Nonsignificant	0.73	0.97	Other	10	13
110	HPC.CLP_B_primed	1.48	Nonsignificant	—	0.21	Other	0	0
111	EPI.salivary_intercalated_defense.inflammatory	1.48	Nonsignificant	0.49	1.02	Other	152	360
112	FIB.transitioning.motility_remodelling	1.47	Nonsignificant	—	0.00	Other	0	0
113	MAC.kupffer.monocyte_like	1.47	Nonsignificant	—	1.39	Other	0	0
114	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.46	Nonsignificant	—	0.60	Other	0	0
115	HPC.MPP_activated	1.46	Nonsignificant	—	0.11	Other	0	0
116	T.CD4_cytotoxic.activated	1.45	Nonsignificant	1.00	0.82	Other	3	1
117	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.43	Nonsignificant	—	0.97	Other	0	0
118	ASPC.inflammatory	1.43	Nonsignificant	0.87	0.86	Other	21	61
119	T.CD8_Tcm.NK_like	1.42	Nonsignificant	0.04	1.42	Other	334	581
120	T.CD8_naive.cytokine_dampened	1.41	Nonsignificant	0.50	1.32	Other	71	4
121	EPI.skin_sebaceous_duct_luminal.detox_repair	1.40	Nonsignificant	0.51	1.43	Other	137	94
122	B.germinal_center.DZ_S_phase	1.38	Nonsignificant	—	0.58	Other	0	0
123	EPI.salivary_myoepithelial.junctional_transport	1.37	Nonsignificant	0.34	1.52	Other	66	121
124	FIB.transitioning.secretory_procollagen	1.36	Nonsignificant	—	0.00	Other	0	0
125	IPSC.proliferative	1.33	Nonsignificant	1.00	0.89	Other	0	0
126	EPI.salivary_myoepithelial.activated	1.32	Nonsignificant	0.39	1.28	Other	85	281
127	EPI.pancreatic_islet.delta	1.31	Nonsignificant	—	0.00	Other	0	0
128	T.CD8_naive.vesicle_secretory	1.31	Nonsignificant	0.50	1.35	Other	42	0
129	EPI.skin_interfollicular_spinous.inflammatory	1.31	Nonsignificant	—	1.08	Other	0	0
130	B.memory.migratory	1.30	Nonsignificant	1.00	0.84	Other	123	208
131	NEU.INH_VIP.develop_niche	1.29	Nonsignificant	—	1.23	Other	0	0
132	FIB.barrier_purinergic.stress_GF_binding	1.26	Nonsignificant	—	0.97	Other	0	0
133	EPI.renal_thick_ascending_limb.cation_flux	1.25	Nonsignificant	0.27	1.34	Other	57	95
134	T.CD8_naive.baseline	1.24	Nonsignificant	1.00	0.89	Other	142	2
135	T.CD8_naive.effector_transition	1.24	Nonsignificant	0.80	1.15	Other	35	62
136	T.CD4_Th2.tissue_adapted	1.24	Nonsignificant	—	0.97	Other	0	0
137	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.23	Nonsignificant	0.83	0.50	Other	2	9
138	THYMO.SP_CD8_naive_stress	1.23	Nonsignificant	1.00	0.45	Other	1	1
139	ILC2.activated	1.20	Nonsignificant	—	0.59	Other	0	0
140	B.germinal_center.LZ_memory_precursor	1.20	Nonsignificant	—	0.00	Other	0	0
141	HPC.LMPP	1.19	Nonsignificant	0.95	0.48	Other	65	31
142	NEU.INH_VIP.cannabinoid	1.18	Nonsignificant	—	1.31	Other	0	0
143	EPI.renal_intercalated_cell_type_A.acid_secretion	1.17	Nonsignificant	0.52	1.01	Other	12	6
144	SCHWN.reactive_inflammatory	1.17	Nonsignificant	—	0.00	Other	0	0
145	T.CD8_naive.innate_like	1.16	Nonsignificant	1.00	0.77	Other	10	1
146	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.15	Nonsignificant	—	0.00	Other	0	0
147	EPI.skin_sweat_duct_keratinocyte.repair	1.15	Nonsignificant	—	0.29	Other	0	0
148	B.germinal_center.DZ_M_phase	1.15	Nonsignificant	—	0.00	Other	0	0
149	T.CD8_Trm.dendritic_recruiter	1.15	Nonsignificant	0.07	1.37	Other	47	85
150	HEP.acute_phase.complement_antiviral	1.14	Nonsignificant	0.02	1.48	Other	377	751
151	FIB.transitioning.ISG_primed_interface	1.14	Nonsignificant	—	0.00	Other	17	80
152	EPI.skin_keratinocyte_progenitor.activated_stress	1.14	Nonsignificant	—	0.00	Other	0	0
153	T.CD4_naive.gut_prone	1.14	Nonsignificant	0.02	1.72	Other	35	70
154	EPI.skin_sebaceous_duct_luminal.immune_interface	1.13	Nonsignificant	—	0.00	Other	0	0
155	FIB.tracheal_subepithelial.baseline	1.09	Nonsignificant	—	0.00	Other	0	0
156	NEU.EXC_NTNG1.nuclear_reg	1.07	Nonsignificant	—	0.67	Other	0	0
157	FIB.adventitial.PI16_matrix	1.07	Nonsignificant	1.23e-06	1.90	Other	70	90
158	T.CD8_naive.lipid_synthesis	1.07	Nonsignificant	1.00	0.97	Other	6	4
159	NEU.INH_PVALB.metabotropic	1.05	Nonsignificant	—	0.50	Other	0	0
160	EPI.salivary_myoepithelial.baseline	1.04	Nonsignificant	0.91	0.46	Other	42	141
161	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	1.04	Nonsignificant	—	0.00	Other	0	0
162	EPI.renal_intercalated_cell_type_A.PC_transitional	1.04	Nonsignificant	—	0.09	Other	203	407
163	T.CD8_naive.splicing_enriched	1.02	Nonsignificant	1.00	0.67	Other	120	16
164	EPI.skin_interfollicular_spinous.proliferative	1.01	Nonsignificant	—	0.61	Other	0	0
165	EPI.skin_interfollicular_spinous.early_differentiation	1.00	Nonsignificant	0.76	1.04	Other	89	19
166	THYMO.proliferative_G2M	0.99	Nonsignificant	—	0.00	Other	164	413
167	FIB.interstitial.mesenchymal_APC	0.98	Nonsignificant	1.00	0.67	Other	81	33
168	T.CD4_Treg.Tr1_like	0.97	Nonsignificant	—	0.46	Other	8	8
169	EPI.pancreatic_acinar.baseline	0.96	Nonsignificant	0.71	1.01	Other	274	163
170	IPSC.endoderm_primed	0.96	Nonsignificant	0.01	1.51	Other	0	0
171	EPI.skin_interfollicular_spinous.baseline	0.94	Nonsignificant	0.76	0.94	Other	35	3
172	FIB.lung_alveolar.mito_secretory	0.92	Nonsignificant	—	0.48	Other	0	0
173	T.CD4_Treg.APC_interactive	0.91	Nonsignificant	0.40	1.33	Other	118	28
174	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.90	Nonsignificant	—	0.03	Other	43	26
175	PC.IgG_systemic.metabolic	0.89	Nonsignificant	4.50e-03	1.84	Other	46	63
176	NEU.INH_PVALB.fastspike	0.89	Nonsignificant	—	0.30	Other	24	22
177	B.memory.preactivated	0.87	Nonsignificant	1.00	0.68	Other	173	174
178	T.CD8_naive.nfkb_related	0.87	Nonsignificant	1.00	0.58	Other	1	0
179	B.naive.activated	0.85	Nonsignificant	0.97	0.62	Other	77	127
180	EPI.skin_interfollicular_spinous.stress_oxidative	0.85	Nonsignificant	—	0.00	Other	0	0
181	FIB.interstitial.immune_interact	0.85	Nonsignificant	1.00	0.26	Other	12	1
182	B.germinal_center.LZ_selection	0.85	Nonsignificant	—	0.00	Other	0	0
183	FIB.interstitial.remodeling	0.85	Nonsignificant	1.00	0.21	Other	31	9
184	EPI.salivary_intercalated_defense.basal_EMT	0.85	Nonsignificant	—	0.00	Other	0	0
185	T.CD8_Trm.inflammatory	0.83	Nonsignificant	0.03	1.37	Other	124	176
186	EPI.pancreatic_ductal_bicarbonate.stress	0.82	Nonsignificant	—	1.66	Other	12	33
187	ILC2.migratory	0.82	Nonsignificant	—	0.00	Other	0	0
188	EPI.salivary_duct_ion_transport.baseline	0.81	Nonsignificant	—	—	Other	0	0
189	EPI.renal_intercalated_cell_type_B.baseline	0.80	Nonsignificant	—	0.00	Other	3	1
190	NEU.INH_PVALB.neuromodulatory	0.80	Nonsignificant	—	0.00	Other	0	0
191	NEU.INH_PVALB.serotonergic	0.79	Nonsignificant	—	0.22	Other	0	0
192	FIB.reticular.stress_metallothionein	0.79	Nonsignificant	—	0.69	Other	3	32
193	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.78	Nonsignificant	—	0.00	Other	0	0
194	EPI.skin_interfollicular_spinous.transition_basal	0.78	Nonsignificant	0.76	0.68	Other	100	127
195	T.gamma_delta.cytotoxic_effector	0.78	Nonsignificant	0.12	1.10	Other	349	109
196	EPI.pancreatic_acinar.inflammatory_regenerative	0.77	Nonsignificant	0.62	1.13	Other	25	113
197	NEU.INH_PVALB.chandelier	0.76	Nonsignificant	0.84	1.05	Other	19	16
198	B.naive.restrained	0.75	Nonsignificant	0.97	0.77	Other	183	353
199	FIB.reticular.ECM_builder	0.75	Nonsignificant	—	0.76	Other	0	0
200	T.CD4_naive.Treg_like	0.74	Nonsignificant	0.30	1.47	Other	121	72
201	NEU.EXC_IT.structural	0.74	Nonsignificant	0.03	1.27	Other	171	41
202	T.CD4_Treg.central_naive_like	0.73	Nonsignificant	0.52	0.97	Other	333	45
203	IPSC.mesodermal_primed	0.73	Nonsignificant	1.00	0.66	Other	0	0
204	EPI.skin_interfollicular_spinous.stress_UPR	0.73	Nonsignificant	—	0.00	Other	0	0
205	EPI.renal_distal_tubule.stress	0.72	Nonsignificant	—	1.16	Other	0	0
206	EPI.colonic_tuft.activated	0.70	Nonsignificant	—	0.00	Other	0	0
207	ASPC.preadipocyte_lipid_primed	0.69	Nonsignificant	1.00	0.08	Other	331	129
208	PLAT.megakaryocytic	0.69	Nonsignificant	—	0.97	Other	0	0
209	DC.pDC.poised_migratory	0.69	Nonsignificant	0.96	0.52	Other	54	95
210	FIB.adventitial.inflammatory_activated	0.68	Nonsignificant	0.27	1.27	Other	100	473
211	EPI.esophageal_suprabasal.differentiating_keratin	0.67	Nonsignificant	4.25e-03	1.96	Other	131	61
212	NEU.INH_PVALB.nuclear_reg	0.67	Nonsignificant	0.84	0.41	Other	25	12
213	EC.arterial.mito_contact	0.67	Nonsignificant	2.83e-03	1.64	Other	14	5
214	FIB.skin_papillary.baseline	0.66	Nonsignificant	—	0.00	Other	0	0
215	EC.venous.remodeling_stalk	0.65	Nonsignificant	0.10	1.59	Other	559	566
216	EPI.tracheal_suprabasal.transitional_wound	0.65	Nonsignificant	—	0.60	Other	16	1
217	EPI.colonic_tuft.homeostatic	0.63	Nonsignificant	—	0.00	Other	0	0
218	FIB.barrier_purinergic.lipid_secretory	0.63	Nonsignificant	—	0.00	Other	0	0
219	T.gamma_delta.early_effector	0.62	Nonsignificant	0.12	1.10	Other	89	0
220	FIB.reticular.immune_interface	0.62	Nonsignificant	—	0.26	Other	1	6
221	FIB.interstitial.mesenchymal_regulator	0.62	Nonsignificant	1.00	0.04	Other	4	4
222	EPI.esophageal_basal.junctional_barrier	0.61	Nonsignificant	—	0.32	Other	0	0
223	HEP.acute_phase.stress_secretory	0.60	Nonsignificant	0.96	0.92	Other	26	3
224	DC.cDC2.migratory	0.60	Nonsignificant	0.71	1.13	Other	185	39
225	HPC.MEP	0.59	Nonsignificant	0.95	0.74	Other	599	1,195
226	MESO.antiviral	0.58	Nonsignificant	—	0.26	Other	3	8
227	FIB.skin_tenogenic.baseline	0.56	Nonsignificant	—	0.00	Other	0	2
228	EPI.salivary_myoepithelial.contractile_repair	0.55	Nonsignificant	—	0.00	Other	3	9
229	T.CD4_Tem.cytotoxic_effector	0.55	Nonsignificant	4.45e-03	1.25	Other	225	398
230	EPI.esophageal_basal.activated_progenitor	0.54	Nonsignificant	0.69	0.85	Other	1	0
231	T.CD4_Treg.tissue_effector	0.54	Nonsignificant	0.52	1.00	Other	16	13
232	FIB.adventitial.mechano_chemo_sensing	0.54	Nonsignificant	0.95	1.06	Other	135	524
233	B.memory.activated	0.53	Nonsignificant	1.00	0.44	Other	105	29
234	T.CD4_naive.neddylation_mitoprot	0.53	Nonsignificant	0.30	1.22	Other	93	56
235	HEP.acute_phase.complement_metabolic	0.53	Nonsignificant	0.96	0.93	Other	1,423	3,464
236	IPSC.mesenchymal_primed	0.53	Nonsignificant	1.00	0.55	Other	0	0
237	FIB.skin_neurosecretory.baseline	0.52	Nonsignificant	—	0.00	Other	0	0
238	FIB.adventitial.activated_remodelling	0.52	Nonsignificant	—	0.00	Other	141	319
239	T.CD4_Trm.activated	0.52	Nonsignificant	0.60	1.22	Other	32	26
240	MESO.secretory_structural	0.52	Nonsignificant	—	0.67	Other	0	0
241	HEP.acute_phase.baseline	0.52	Nonsignificant	0.96	0.90	Other	946	19
242	NEU.EXC_NTNG1.synaptic	0.51	Nonsignificant	—	0.00	Other	0	0
243	ILC2.quiescent	0.51	Nonsignificant	—	0.00	Other	0	0
244	EPI.skin_follicular_keratinizing.transit_amplifying	0.50	Nonsignificant	—	0.94	Other	21	49
245	T.CD4_naive.proteostasis	0.49	Nonsignificant	0.78	1.08	Other	14	9
246	EC.capillary.angiogenic_tip	0.49	Nonsignificant	0.42	1.30	Other	186	218
247	EPI.thymic_cortical.Notch_interface	0.49	Nonsignificant	—	0.18	Other	82	137
248	EPI.thymic_cortical.baseline	0.49	Nonsignificant	0.79	0.51	Other	185	386
249	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.49	Nonsignificant	—	0.00	Other	0	0
250	EPI.lung_club_secretory.inflammatory	0.48	Nonsignificant	—	0.79	Other	0	0
251	HEP.acute_phase.proliferative	0.48	Nonsignificant	—	0.00	Other	4	6
252	EPI.thymic_cortical.secretory_remodeling	0.48	Nonsignificant	—	0.00	Other	4	1
253	THYMO.proliferative_S	0.48	Nonsignificant	1.00	0.15	Other	163	418
254	FIB.adventitial.complement_angiocrine	0.48	Nonsignificant	1.00	0.87	Other	153	684
255	T.CD4_Tfh.suppression_exhaustion	0.48	Nonsignificant	0.40	1.29	Other	0	2
256	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.47	Nonsignificant	0.48	1.21	Other	322	317
257	EPI.skin_interfollicular_spinous.upper_lipid	0.47	Nonsignificant	—	0.00	Other	6	6
258	GRANU.MAST.resting_granule	0.47	Nonsignificant	—	0.95	Other	0	0
259	T.CD4_naive.survival_neddylation	0.46	Nonsignificant	0.78	1.09	Other	26	38
260	EPI.renal_thick_ascending_limb.remodeling	0.46	Nonsignificant	0.48	1.15	Other	152	92
261	T.CD4_naive.neddylation	0.45	Nonsignificant	0.30	1.22	Other	104	222
262	T.CD4_cytotoxic.baseline	0.45	Nonsignificant	1.00	0.39	Other	0	0
263	EPI.skin_hair_follicle_companion.activated_migratory	0.45	Nonsignificant	—	0.00	Other	0	0
264	FIB.lung_alveolar.stress_interacting	0.44	Nonsignificant	—	0.00	Other	0	0
265	EC.arterial.arteriole_interface	0.44	Nonsignificant	0.42	1.20	Other	31	12
266	EPI.tracheal_submucosal_gland.acinar_serous	0.43	Nonsignificant	—	0.73	Other	0	0
267	T.CD8_transitional.APC_like	0.43	Nonsignificant	1.00	0.76	Other	205	62
268	T.CD4_naive.proteostasis_mitoprot	0.42	Nonsignificant	0.85	0.93	Other	15	37
269	T.CD4_naive.survival	0.42	Nonsignificant	0.82	0.97	Other	12	17
270	T.CD4_naive.survival_mitoprot	0.41	Nonsignificant	0.48	1.21	Other	13	7
271	T.CD4_naive.mature_mitoprot	0.41	Nonsignificant	0.85	0.95	Other	212	476
272	EC.arterial.arteriole_gas_exchange	0.41	Nonsignificant	0.02	1.35	Other	238	131
273	PC.IgA_muocsal.baseline	0.41	Nonsignificant	0.59	1.16	Other	3	5
274	FIB.adventitial.mito_secretory	0.40	Nonsignificant	1.00	0.81	Other	21	7
275	DC.mig.baseline	0.40	Nonsignificant	—	0.00	Other	1	0
276	PC.IgG_systemic.stress	0.40	Nonsignificant	—	0.00	Other	1	5
277	T.CD4_naive.mature	0.39	Nonsignificant	1.00	0.81	Other	211	100
278	T.CD4_naive.purinergic	0.39	Nonsignificant	0.82	0.97	Other	49	1
279	MUSC.quiescent_reservoir	0.39	Nonsignificant	0.07	1.85	Other	2	8
280	ASPC.activated	0.39	Nonsignificant	1.00	0.02	Other	164	162
281	EPI.tracheal_suprabasal.secretory_immune	0.39	Nonsignificant	—	0.00	Other	0	0
282	NEU.EXC_IT.guidance	0.38	Nonsignificant	1.00	1.04	Other	274	63
283	HEP.periportal_metabolic.stress_chaperone	0.38	Nonsignificant	—	0.91	Other	66	128
284	PC.IgG_systemic.interacting	0.37	Nonsignificant	1.00	0.74	Other	0	0
285	T.CD4_naive.resist_bystander	0.37	Nonsignificant	0.82	1.01	Other	40	25
286	T.CD8_transitional.stress	0.37	Nonsignificant	—	0.30	Other	24	34
287	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.36	Nonsignificant	—	0.00	Other	10	20
288	EC.arterial.ion_pump	0.36	Nonsignificant	1.00	0.92	Other	3	2
289	EC.capillary.activated	0.36	Nonsignificant	0.50	1.26	Other	2	5
290	T.CD4_Tfh.effector_migratory	0.36	Nonsignificant	0.40	1.26	Other	122	57
291	EPI.renal_distal_tubule.immune_modulatory	0.36	Nonsignificant	—	0.58	Other	0	0
292	T.CD4_naive.homeostatic	0.35	Nonsignificant	1.00	0.66	Other	215	108
293	EPI.lung_club_secretory.canonical_surfactant	0.35	Nonsignificant	—	0.37	Other	74	104
294	EC.venous.baseline	0.35	Nonsignificant	0.46	1.13	Other	346	807
295	FIB.skin_sheath.neuro_vascular_interface	0.34	Nonsignificant	—	1.03	Other	0	0
296	PC.IgA_muocsal.plasmablast	0.34	Nonsignificant	0.59	1.15	Other	5	4
297	T.CD4_Th2.precursor	0.34	Nonsignificant	—	0.00	Other	0	0
298	EC.arterial.angiogenic_tip	0.33	Nonsignificant	—	0.10	Other	30	37
299	T.CD8_Trm.cytotoxic	0.33	Nonsignificant	1.00	0.92	Other	165	85
300	FIB.reticular.stromal_niche	0.32	Nonsignificant	1.00	0.00	Other	0	0
301	EPI.renal_proximal_tubule.detox_antioxidant	0.32	Nonsignificant	7.44e-03	2.49	Other	394	77
302	T.CD8_naive.mito_proteostasis	0.30	Nonsignificant	1.00	0.05	Other	428	100
303	EPI.colonocyte.junction_remodeling	0.30	Nonsignificant	0.01	1.72	Other	218	305
304	EPI.esophageal_suprabasal.basal_transitional	0.30	Nonsignificant	0.94	0.38	Other	44	67
305	PC.IgA_muocsal.migratory	0.30	Nonsignificant	0.59	1.04	Other	4	1
306	EC.arterial.elastic	0.30	Nonsignificant	1.00	0.74	Other	22	45
307	DC.cDC2.monocyte_like	0.29	Nonsignificant	0.71	1.11	Other	1,285	791
308	T.CD8_Trm.homeostatic	0.29	Nonsignificant	1.00	0.73	Other	42	5
309	EPI.salivary_serous_acinar.secretory_active	0.29	Nonsignificant	1.00	0.13	Other	242	69
310	EC.arterial.inflammatory	0.29	Nonsignificant	1.00	0.94	Other	63	50
311	T.CD8_Tcm.baseline	0.29	Nonsignificant	1.00	1.03	Other	90	89
312	THYMO.DN_preTCR	0.29	Nonsignificant	1.00	0.04	Other	41	71
313	EPI.skin_follicular_keratinizing.upper_infundibulum	0.28	Nonsignificant	—	0.00	Other	8	2
314	MONO.CD14.remodeling	0.28	Nonsignificant	9.87e-05	1.33	Other	2,373	295
315	EPI.skin_follicular_keratinizing.root_infundibulum	0.28	Nonsignificant	—	0.00	Other	0	0
316	MAC.resident_iron.stress_tolerogenic	0.28	Nonsignificant	—	1.39	Other	0	0
317	EC.venous.cardiac_structural	0.28	Nonsignificant	0.82	1.10	Other	102	229
318	EPI.lung_club_secretory.ciliogenesis_primed	0.28	Nonsignificant	—	0.37	Other	0	0
319	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.27	Nonsignificant	—	1.04	Other	29	88
320	FIB.adventitial.baseline	0.27	Nonsignificant	1.00	0.23	Other	157	278
321	FIB.perivascular_interface.lipid_shuttle	0.27	Nonsignificant	—	0.16	Other	51	170
322	MUSC.baseline	0.27	Nonsignificant	0.94	0.90	Other	0	0
323	EC.liver_sinusoidal.prostanoid	0.27	Nonsignificant	—	0.53	Other	11	64
324	T.CD8_transitional.Trm_primed	0.27	Nonsignificant	1.00	0.69	Other	108	15
325	T.CD4_Tfh.canonical_GC_helper	0.26	Nonsignificant	0.75	0.78	Other	1	2
326	IPSC.neural_primed	0.26	Nonsignificant	1.00	0.36	Other	0	0
327	PC.IgA_muocsal.activated	0.26	Nonsignificant	0.69	0.92	Other	17	8
328	EC.venous.quiescent_homeostatic	0.26	Nonsignificant	0.88	0.82	Other	456	360
329	T.CD4_Tfh.precursor_migratory	0.25	Nonsignificant	0.60	1.03	Other	72	27
330	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.25	Nonsignificant	—	0.87	Other	135	290
331	EPI.salivary_serous_acinar.seromucous_like	0.25	Nonsignificant	—	0.00	Other	0	0
332	THYMO.DP_early_stress	0.25	Nonsignificant	—	0.00	Other	0	0
333	FIB.adventitial.adhesion_lipid	0.24	Nonsignificant	1.00	0.13	Other	58	209
334	EPI.renal_distal_tubule.ciliated_remodelling	0.24	Nonsignificant	—	0.39	Other	0	0
335	OPC.homeostatic	0.24	Nonsignificant	0.08	1.49	Other	394	160
336	EPI.pancreatic_ductal_progenitor.ADM_like	0.23	Nonsignificant	—	1.65	Other	0	0
337	EPI.tracheal_submucosal_gland.ductal_luminal	0.23	Nonsignificant	—	0.00	Other	0	0
338	MONO.CD14.platelet_bound	0.23	Nonsignificant	0.56	1.12	Other	964	176
339	FIB.skin_sheath.ECM_immune	0.23	Nonsignificant	—	0.00	Other	0	0
340	T.CD4_Trm.baseline	0.22	Nonsignificant	0.58	1.16	Other	31	21
341	EPI.ileal_bile_transport.absorptive_xenobiotic	0.22	Nonsignificant	0.08	1.71	Other	11	12
342	FIB.perivascular_interface.vascular_BM_remodelling	0.22	Nonsignificant	—	0.08	Other	0	0
343	GRANU.MAST.activated_acute	0.22	Nonsignificant	—	0.00	Other	0	0
344	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.21	Nonsignificant	1.00	0.00	Other	58	89
345	MONO.CD14.inflammatory	0.21	Nonsignificant	0.06	1.50	Other	92	134
346	GRANU.MAST.activated_repair	0.21	Nonsignificant	—	0.00	Other	0	1
347	T.CD4_Trm.metal_stress	0.20	Nonsignificant	0.78	1.09	Other	34	58
348	EC.liver_sinusoidal.secretory_lipoprotein	0.19	Nonsignificant	0.42	1.17	Other	120	70
349	EC.capillary.inflammatory	0.19	Nonsignificant	0.82	1.00	Other	27	51
350	ADIPO.thermogenic	0.19	Nonsignificant	—	1.28	Other	0	0
351	FIB.perivascular_interface.vasomotor_tone	0.19	Nonsignificant	—	0.00	Other	0	0
352	MUSC.early_activation	0.19	Nonsignificant	0.94	0.62	Other	4	32
353	EPI.ileal_enterocyte_absorptive.villus_tip	0.18	Nonsignificant	2.67e-08	1.76	Other	4	3
354	MONO.CD14.APC_like	0.18	Nonsignificant	0.86	1.00	Other	1,686	2,493
355	EPI.esophageal_suprabasal.proliferative_S	0.18	Nonsignificant	—	0.00	Other	26	41
356	T.CD4_transitional.APC_interacting	0.18	Nonsignificant	0.43	1.14	Other	10	14
357	OPC.proliferative_immune_interact	0.18	Nonsignificant	0.57	1.09	Other	180	373
358	EPI.skin_keratinocyte_basal.basement_anchoring	0.18	Nonsignificant	—	0.97	Other	0	0
359	THYMO.SP_CD8_transitional	0.18	Nonsignificant	1.00	0.04	Other	32	75
360	FIB.skin_sheath.stress_chaperone	0.18	Nonsignificant	—	0.00	Other	0	0
361	PC.IgG_systemic.secretory	0.17	Nonsignificant	1.00	0.07	Other	0	0
362	MUSC.activated_migratory	0.17	Nonsignificant	0.94	0.32	Other	6	7
363	T.CD4_Tcm.Th2_like	0.17	Nonsignificant	0.58	1.25	Other	23	55
364	EC.venous.adipose_lipid	0.17	Nonsignificant	0.88	0.87	Other	254	476
365	NEU.EXC_IT.callosal	0.16	Nonsignificant	1.00	0.92	Other	286	119
366	MONO.CD16.hepatic_mac_like	0.16	Nonsignificant	0.48	1.17	Other	803	117
367	T.CD4_transitional.primed_helper_effector	0.16	Nonsignificant	0.43	1.16	Other	19	43
368	MONO.CD16.baseline	0.16	Nonsignificant	0.50	1.11	Other	50	1
369	EPI.thymic_medullary.proliferative_APC	0.16	Nonsignificant	—	1.20	Other	0	0
370	T.CD4_transitional.baseline	0.15	Nonsignificant	0.40	1.21	Other	59	97
371	EPI.ileal_enterocyte_crypt.villus_transition	0.15	Nonsignificant	—	1.58	Other	7	10
372	EC.venous.activated	0.15	Nonsignificant	0.99	0.42	Other	247	752
373	MONO.CD14.baseline	0.15	Nonsignificant	1.00	0.65	Other	2,268	76
374	EC.capillary.baseline	0.15	Nonsignificant	0.50	1.06	Other	246	560
375	T.CD4_Tem.inflammatory	0.15	Nonsignificant	1.00	0.85	Other	28	6
376	EPI.colonocyte.goblet_interface	0.14	Nonsignificant	—	0.35	Other	11	21
377	T.CD8_transitional.early	0.14	Nonsignificant	1.00	0.52	Other	327	55
378	T.CD4_Tcm.Tfh_like	0.14	Nonsignificant	0.72	1.04	Other	102	214
379	EC.capillary.postcap_venule	0.14	Nonsignificant	0.84	0.96	Other	355	261
380	MONO.CD16.platelet_bound	0.14	Nonsignificant	0.79	0.90	Other	372	508
381	EPI.ileal_bile_transport.detox_transcytosis	0.14	Nonsignificant	—	0.00	Other	0	1
382	MESO.activated_stress	0.14	Nonsignificant	—	0.00	Other	0	0
383	T.CD4_Tcm.migratory_cilium	0.14	Nonsignificant	0.58	1.21	Other	5	10
384	EPI.colonocyte.crypt_progenitor	0.14	Nonsignificant	0.17	1.35	Other	115	265
385	EPI.renal_principal_cell.intercalated_like	0.14	Nonsignificant	0.03	1.50	Other	63	66
386	HEP.acute_phase.inflammatory	0.14	Nonsignificant	0.99	0.60	Other	382	649
387	SMC.activated	0.14	Nonsignificant	0.09	1.35	Other	2	5
388	T.CD4_Tcm.baseline	0.13	Nonsignificant	0.72	1.07	Other	61	31
389	T.CD4_Tcm.APC_mimicry	0.13	Nonsignificant	0.58	1.22	Other	54	43
390	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	0.13	Nonsignificant	—	0.36	Other	0	0
391	T.CD8_Trm.muscosal_Tc17	0.13	Nonsignificant	1.00	0.38	Other	19	38
392	MONO.CD16.inflammatory	0.13	Nonsignificant	0.08	1.32	Other	1,640	168
393	T.CD8_Tcm.helper_like	0.13	Nonsignificant	1.00	0.83	Other	81	159
394	EC.arterial.metabolic	0.13	Nonsignificant	1.00	0.40	Other	195	159
395	EPI.alveolar_type_1.activated	0.12	Nonsignificant	—	1.64	Other	0	0
396	EC.capillary.stress	0.12	Nonsignificant	0.95	0.86	Other	44	36
397	PERI.baseline	0.12	Nonsignificant	0.07	1.31	Other	39	66
398	IPSC.neuroendocrine_primed	0.11	Nonsignificant	—	0.00	Other	0	0
399	EC.capillary.migratory	0.11	Nonsignificant	0.50	1.14	Other	181	509
400	EPI.renal_immature_ureteric_bud.defense_secretory	0.11	Nonsignificant	0.76	1.11	Other	45	76
401	IPSC.midbrain_primed	0.11	Nonsignificant	1.00	0.26	Other	0	0
402	ASTRO.hypoxia_angiogenic	0.11	Nonsignificant	0.14	1.32	Other	5	18
403	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.11	Nonsignificant	—	0.00	Other	0	0
404	EC.arterial.homeostatic	0.11	Nonsignificant	1.00	0.22	Other	24	3
405	T.CD4_Tcm.crosstalk_myeloid	0.11	Nonsignificant	0.72	1.05	Other	5	4
406	EPI.pancreatic_ductal_progenitor.baseline	0.10	Nonsignificant	0.55	0.93	Other	179	702
407	T.CD4_Tem.transitional_CM	0.10	Nonsignificant	1.00	0.82	Other	31	20
408	EPI.renal_principal_cell.inflammatory	0.10	Nonsignificant	0.79	1.14	Other	74	157
409	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.10	Nonsignificant	0.02	1.63	Other	7	16
410	MESO.baseline	0.10	Nonsignificant	0.87	0.71	Other	0	6
411	MONO.CD16.patrolling	0.10	Nonsignificant	1.00	0.60	Other	797	216
412	MESO.activated_migratory	0.09	Nonsignificant	—	0.00	Other	0	0
413	IPSC.stress	0.09	Nonsignificant	1.00	0.23	Other	0	0
414	EPI.esophageal_suprabasal.proliferative_exit	0.09	Nonsignificant	—	0.00	Other	0	0
415	T.CD4_Tcm.imprinted_splicing	0.09	Nonsignificant	0.72	1.07	Other	6	17
416	EPI.esophageal_suprabasal.proliferative_G2M	0.08	Nonsignificant	—	0.00	Other	0	0
417	NEU.INH_VIP.matrix	0.08	Nonsignificant	—	0.73	Other	24	77
418	EPI.ileal_enterocyte_crypt.bile_transport	0.08	Nonsignificant	0.36	1.26	Other	2	0
419	T.CD4_Tcm.DC_interact	0.08	Nonsignificant	0.72	1.08	Other	72	32
420	SMC.metabolic	0.08	Nonsignificant	0.99	0.88	Other	14	40
421	T.CD4_Tcm.stress	0.08	Nonsignificant	0.58	1.22	Other	5	11
422	T.CD4_Th17.migratory	0.08	Nonsignificant	0.60	1.07	Other	13	23
423	MAC.resident_repair.lipid_phagocytic	0.08	Nonsignificant	0.06	1.35	Other	228	604
424	MAC.resident_iron.heme_catabolism	0.08	Nonsignificant	0.29	1.22	Other	30	51
425	EPI.renal_immature_ureteric_bud.osmoprotective	0.08	Nonsignificant	0.82	0.77	Other	126	44
426	EPI.ectocervical_granular.secretory_apocrine	0.07	Nonsignificant	—	1.15	Other	0	0
427	MAC.microglia_like.inflammatory_chemokine	0.07	Nonsignificant	—	0.77	Other	20	32
428	T.CD4_Trm.cytotoxic_effector	0.07	Nonsignificant	0.96	0.77	Other	118	77
429	HEP.periportal_metabolic.stress_checkpoint	0.07	Nonsignificant	0.47	1.12	Other	234	786
430	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.07	Nonsignificant	—	0.00	Other	0	0
431	EPI.colonocyte.proximal_transport	0.07	Nonsignificant	1.00	0.37	Other	24	12
432	EPI.colonocyte.ionocyte_BEST4	0.07	Nonsignificant	0.69	1.08	Other	103	188
433	EPI.thymic_medullary.stress_APC	0.07	Nonsignificant	0.52	1.33	Other	2	4
434	T.CD4_Th17.cytotoxic	0.07	Nonsignificant	3.40e-03	1.25	Other	332	123
435	MAC.kupffer.stress	0.07	Nonsignificant	0.52	1.00	Other	9	3
436	T.CD4_Trm.central_like	0.06	Nonsignificant	0.96	0.78	Other	38	31
437	T.CD4_Trm.helper_like	0.06	Nonsignificant	0.96	0.73	Other	84	147
438	T.CD4_Tcm.regulatory_poised	0.06	Nonsignificant	0.97	0.90	Other	2	3
439	T.CD4_Tcm.synapse_dynamics	0.06	Nonsignificant	0.97	0.84	Other	15	10
440	MEL.dedifferentiated_migratory	0.06	Nonsignificant	—	0.87	Other	0	0
441	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.06	Nonsignificant	—	0.13	Other	39	82
442	T.CD4_transitional.primed_cytotoxic	0.06	Nonsignificant	0.91	0.72	Other	28	30
443	MONO.CD14.repair_M2_like	0.06	Nonsignificant	1.00	0.48	Other	550	1,495
444	T.CD4_Tcm.RNA_control	0.06	Nonsignificant	0.97	0.83	Other	96	4
445	EC.capillary.angiocrine	0.06	Nonsignificant	0.99	0.69	Other	250	630
446	T.CD4_Tcm.secretory	0.06	Nonsignificant	0.97	0.85	Other	20	11
447	DC.cDC2.adhesion_signaling	0.05	Nonsignificant	0.72	1.06	Other	35	9
448	T.CD4_Trm.stress_adaptive	0.05	Nonsignificant	0.96	0.79	Other	8	22
449	EPI.pancreatic_ductal_perivascular.baseline	0.05	Nonsignificant	0.19	1.41	Other	1	5
450	OPC.premyelinating	0.05	Nonsignificant	1.00	0.00	Other	185	12
451	SMC.contractile	0.05	Nonsignificant	0.99	0.62	Other	80	588
452	EPI.gastric_foveolar.baseline	0.05	Nonsignificant	—	0.00	Other	0	0
453	EPI.skin_keratinocyte_proliferating.detox_repair	0.05	Nonsignificant	—	0.00	Other	0	0
454	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.05	Nonsignificant	—	0.04	Other	11	69
455	T.CD4_Tcm.tissue_homing	0.05	Nonsignificant	0.97	0.75	Other	78	46
456	PERI.inflammatory	0.05	Nonsignificant	0.33	1.15	Other	40	77
457	MAC.LAM.lipid_opsonization	0.05	Nonsignificant	0.73	1.21	Other	45	14
458	T.CD4_cytotoxic.precursor	0.04	Nonsignificant	1.00	0.00	Other	156	67
459	FIB.suburothelial.inflammatory_prostanoid	0.04	Nonsignificant	—	0.33	Other	0	0
460	T.CD4_transitional.tissue_enagement	0.04	Nonsignificant	0.91	0.74	Other	5	11
461	EPI.skin_hair_follicle_bulge.quiescent	0.04	Nonsignificant	0.91	0.41	Other	56	69
462	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.04	Nonsignificant	0.88	0.65	Other	33	34
463	MAC.kupffer.inflammatory	0.04	Nonsignificant	—	0.00	Other	7	4
464	HEP.periportal_metabolic.xenobiotic_detox	0.04	Nonsignificant	0.84	1.03	Other	1,440	139
465	ASTRO.synaptic_interaction	0.04	Nonsignificant	0.79	1.09	Other	76	334
466	MAC.resident_iron.APC_iron_sensing	0.04	Nonsignificant	0.85	0.86	Other	211	114
467	T.CD4_Tcm.effector_like	0.04	Nonsignificant	0.97	0.91	Other	293	533
468	EPI.renal_principal_cell.canonical_vasopressin	0.04	Nonsignificant	0.79	0.86	Other	2	0
469	FIB.suburothelial.homeostasis_matrix	0.04	Nonsignificant	0.40	1.36	Other	258	921
470	PLAT.adhesion	0.04	Nonsignificant	—	0.00	Other	0	0
471	EC.liver_sinusoidal.inflammatory	0.04	Nonsignificant	—	0.00	Other	223	154
472	FIB.suburothelial.urothelial_interface	0.03	Nonsignificant	0.86	0.50	Other	9	8
473	EPI.renal_thick_ascending_limb.salt_sensing	0.03	Nonsignificant	1.00	0.52	Other	73	103
474	FIB.suburothelial.contractile_myofibroblast	0.03	Nonsignificant	—	0.00	Other	9	0
475	MAC.resident_iron.redox_metabolic	0.03	Nonsignificant	0.85	0.93	Other	4	4
476	EPI.thymic_medullary.canonical_alarmin	0.03	Nonsignificant	0.80	0.63	Other	8	17
477	T.CD4_Tcm.retro_ZNF117	0.03	Nonsignificant	0.97	0.60	Other	5	9
478	EPI.bile_duct_cholangiocyte.secretory_mucin	0.03	Nonsignificant	—	0.62	Other	7	12
479	MG.baseline	0.03	Nonsignificant	0.19	1.20	Other	16	5
480	MEL.neurotrophic_migratory	0.03	Nonsignificant	—	1.27	Other	0	0
481	MAC.MDM.inflammatory_phagocytic	0.03	Nonsignificant	0.15	1.14	Other	199	52
482	PERI.angiocrine	0.03	Nonsignificant	0.95	0.91	Other	93	102
483	NEU.EXC_CT.projector	0.03	Nonsignificant	0.34	1.11	Other	87	26
484	EC.liver_sinusoidal.hypoxia_metabolic	0.03	Nonsignificant	0.93	0.70	Other	183	107
485	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.03	Nonsignificant	—	0.00	Other	0	0
486	ADIPO.hypoxia_remodelling	0.03	Nonsignificant	—	0.00	Other	29	105
487	EPI.colonocyte.secretory_boost	0.03	Nonsignificant	1.00	0.29	Other	98	91
488	NEU.EXC_IT.adhesion	0.03	Nonsignificant	1.00	0.64	Other	252	108
489	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.03	Nonsignificant	—	0.00	Other	105	368
490	EPI.renal_principal_cell.injury_repair	0.03	Nonsignificant	0.79	0.96	Other	26	9
491	FIB.hepatic_stellate_cell.fibrogenic	0.02	Nonsignificant	—	0.73	Other	0	0
492	EPI.renal_principal_cell.activated_acute	0.02	Nonsignificant	0.79	0.76	Other	29	59
493	EPI.thymic_medullary.hormone_xeno_barrier	0.02	Nonsignificant	—	0.00	Other	0	8
494	EPI.ectocervical_granular.proliferative_basal	0.02	Nonsignificant	—	0.32	Other	0	0
495	EPI.ileal_enterocyte_crypt.baseline	0.02	Nonsignificant	0.98	0.54	Other	11	6
496	FIB.hepatic_stellate_cell.inflammatory	0.02	Nonsignificant	—	0.00	Other	0	0
497	DC.cDC2.lipid_metabolic	0.02	Nonsignificant	—	0.02	Other	0	0
498	EC.heart_remodeling.remodeling_stalk	0.02	Nonsignificant	0.03	1.32	Other	33	111
499	NEU.EXC_CT.remodeling	0.02	Nonsignificant	—	0.30	Other	23	1
500	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.02	Nonsignificant	0.82	1.17	Other	40	191
501	EPI.ileal_enterocyte_crypt.proliferative_S	0.02	Nonsignificant	0.98	0.73	Other	4	2
502	EPI.ectocervical_granular.immune_interact	0.02	Nonsignificant	—	0.00	Other	0	0
503	ADIPO.immature	0.02	Nonsignificant	—	0.00	Other	24	40
504	EC.lymphatic.scavenger	0.02	Nonsignificant	0.44	1.22	Other	203	257
505	GRNLSA.secretory_remodeling	0.02	Nonsignificant	0.60	1.08	Other	90	25
506	T.CD4_naive.activated_stress	0.02	Nonsignificant	1.00	0.00	Other	339	429
507	EPI.renal_thick_ascending_limb.barrier_repair	0.02	Nonsignificant	1.00	0.29	Other	141	284
508	NEU.INH_VIP.enkephalinergic	0.02	Nonsignificant	—	0.36	Other	0	0
509	NEU.EXC_IT.transitional	0.02	Nonsignificant	1.00	0.63	Other	237	142
510	NEU.EXC_SYT2.synaptic	0.02	Nonsignificant	—	0.48	Other	0	0
511	EPI.endocervical_secretory.squamous_barrier	0.02	Nonsignificant	—	0.67	Other	0	0
512	HEP.pericentral_lipoprotein.ApoB_coagulation	0.02	Nonsignificant	—	0.67	Other	0	0
513	T.CD4_Th17.baseline	0.02	Nonsignificant	0.90	0.85	Other	51	5
514	FIB.hepatic_stellate_cell.contractile	0.02	Nonsignificant	—	0.00	Other	0	0
515	NEU.INH_VIP.nuclear_reg	0.02	Nonsignificant	—	0.16	Other	20	4
516	DC.cDC2.antiviral	0.02	Nonsignificant	1.00	0.81	Other	100	37
517	HEP.periportal_metabolic.canonical_urea_cycle	0.01	Nonsignificant	1.00	0.96	Other	1,464	269
518	EPI.alveolar_type_2.baseline_surfactant	0.01	Nonsignificant	0.55	1.18	Other	64	9
519	ASTRO.stress_acute	0.01	Nonsignificant	1.00	1.09	Other	60	56
520	GRNLSA.chemokine_mechanosensory	0.01	Nonsignificant	0.60	1.05	Other	1	0
521	EC.liver_sinusoidal.stress	0.01	Nonsignificant	—	0.00	Other	413	158
522	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	1.00	0.73	Other	314	587
523	MAC.proliferating.DNA_replication	0.01	Nonsignificant	0.11	1.14	Other	3	6
524	GRNLSA.lipid_hypoxia	0.01	Nonsignificant	0.23	1.27	Other	28	0
525	T.CD8_Tcm.gut_homing	0.01	Nonsignificant	1.00	0.32	Other	380	112
526	EPI.ileal_enterocyte_absorptive.brush_border	0.01	Nonsignificant	1.00	0.00	Other	580	1,717
527	MAC.resident_cardiac.antigen_presenting	0.01	Nonsignificant	0.30	1.16	Other	52	27
528	MEL.secretory_quiescent	0.01	Nonsignificant	0.93	1.07	Other	19	13
529	CHOND.angiogenic	9.97e-03	Nonsignificant	—	1.84	Other	0	0
530	EPI.pancreatic_acinar.metabolic_onecarbon	9.92e-03	Nonsignificant	1.00	0.40	Other	287	328
531	GRNLSA.proliferative_migratory	9.81e-03	Nonsignificant	0.61	0.96	Other	248	292
532	HEP.periportal_metabolic.acute_phase_barrier	8.89e-03	Nonsignificant	0.47	1.10	Other	533	138
533	EC.heart_remodeling.remodeling_secretory	8.80e-03	Nonsignificant	0.38	1.15	Other	605	1,341
534	NEU.EXC_IT.neuromodulated	8.33e-03	Nonsignificant	1.00	0.52	Other	176	116
535	MAC.resident_repair.antigen_presenting	7.99e-03	Nonsignificant	0.84	1.04	Other	244	113
536	NEU.INH_VIP.regulatory_remodeling	7.51e-03	Nonsignificant	—	0.00	Other	6	1
537	PERI.cardiac_skeletal	6.78e-03	Nonsignificant	1.00	0.08	Other	313	630
538	MAC.resident_repair.chemokine_angiocrine	6.32e-03	Nonsignificant	0.84	1.05	Other	87	138
539	HEP.periportal_metabolic.urea_onecarbon_secretory	6.31e-03	Nonsignificant	1.00	0.88	Other	1,332	3,053
540	T.MAIT.MAPK_brake	6.28e-03	Nonsignificant	0.26	1.17	Other	44	66
541	MAC.microglia_like.patrolling_adhesive	6.23e-03	Nonsignificant	—	0.00	Other	0	0
542	CHOND.remodeling	6.03e-03	Nonsignificant	—	0.74	Other	5	0
543	GRNLSA.cholesterol_mevalonate	5.92e-03	Nonsignificant	0.60	1.04	Other	9	4
544	HEP.pericentral_lipoprotein.UPR_redox	5.74e-03	Nonsignificant	—	0.00	Other	0	0
545	EPI.colonic_enteroendocrine.progenitor	5.69e-03	Nonsignificant	—	0.00	Other	0	0
546	MAC.microglia_like.phagocytic_redox	5.68e-03	Nonsignificant	—	0.00	Other	0	0
547	EPI.ectocervical_granular.inflammatory	5.61e-03	Nonsignificant	—	0.00	Other	0	0
548	EPI.skin_hair_follicle_bulge.anagen_growth	5.29e-03	Nonsignificant	—	0.00	Other	0	0
549	T.MAIT.cytotoxic	5.25e-03	Nonsignificant	0.39	1.17	Other	52	15
550	EC.heart_remodeling.perivascular	5.18e-03	Nonsignificant	0.70	1.03	Other	124	408
551	NEU.INH_VIP.serotonergic	5.18e-03	Nonsignificant	—	0.00	Other	9	2
552	EC.lymphatic.tip_migratory	5.16e-03	Nonsignificant	0.84	0.98	Other	23	37
553	EC.lymphatic.activated	5.13e-03	Nonsignificant	0.84	0.92	Other	47	73
554	MAC.LAM.inflammatory_APC	5.12e-03	Nonsignificant	0.96	0.97	Other	872	165
555	EPI.alveolar_type_1.baseline	5.11e-03	Nonsignificant	1.00	0.00	Other	8	0
556	NEU.INH_VIP.excitatory_coupled	5.06e-03	Nonsignificant	—	0.00	Other	13	0
557	T.MAIT.early_activation	4.97e-03	Nonsignificant	0.55	1.08	Other	57	4
558	MG.expanding	4.88e-03	Nonsignificant	0.89	0.94	Other	2	1
559	EPI.ileal_enterocyte_crypt.proliferative_G2M	4.81e-03	Nonsignificant	—	0.00	Other	19	54
560	EPI.skin_appendage_keratinocyte.transit_amplifying	4.60e-03	Nonsignificant	—	0.00	Other	109	358
561	EPI.colonocyte.distal_absorptive	4.52e-03	Nonsignificant	—	0.00	Other	0	0
562	EC.lymphatic.baseline	4.19e-03	Nonsignificant	0.84	0.82	Other	38	72
563	T.MAIT.migratory	4.13e-03	Nonsignificant	0.55	1.11	Other	10	1
564	GRNLSA.stress_metabolic	4.12e-03	Nonsignificant	—	0.09	Other	1	2
565	T.CD8_Tcm.effector_bias	3.46e-03	Nonsignificant	1.00	0.16	Other	199	329
566	CHOND.articular_collagen	3.30e-03	Nonsignificant	0.80	1.08	Other	551	266
567	CM.contractile_oxphos	3.24e-03	Nonsignificant	0.83	1.08	Other	6	19
568	EC.heart_remodeling.angiocrine	3.20e-03	Nonsignificant	0.72	0.91	Other	182	525
569	EPI.renal_distal_tubule.repair	2.96e-03	Nonsignificant	—	0.00	Other	34	102
570	ASTRO.neuromodulatory	2.90e-03	Nonsignificant	1.00	0.96	Other	34	172
571	EC.heart_remodeling.capillary_metabolic	2.72e-03	Nonsignificant	0.38	1.27	Other	54	414
572	EPI.ileal_goblet.immature	2.57e-03	Nonsignificant	—	0.00	Other	0	0
573	SKM.type_2_fast.glycolytic_IIx_IIb	2.51e-03	Nonsignificant	0.31	1.17	Other	565	1,482
574	IPSC.canonical_pluripotent	2.31e-03	Nonsignificant	1.00	0.00	Other	0	0
575	CM.baseline	2.19e-03	Nonsignificant	0.83	1.02	Other	393	0
576	GRNLSA.EMT_insulin_signaling	2.05e-03	Nonsignificant	0.60	1.02	Other	47	84
577	SKM.type_2_fast.oxidative_IIa	1.99e-03	Nonsignificant	0.90	0.80	Other	946	56
578	DC.cDC2.pro_inflammatory	1.92e-03	Nonsignificant	1.00	0.73	Other	3	5
579	EPI.ileal_goblet.inflammatory_mucin	1.86e-03	Nonsignificant	0.75	1.13	Other	6	9
580	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.84e-03	Nonsignificant	—	0.92	Other	0	0
581	NEU.INH_VIP.opioid	1.80e-03	Nonsignificant	—	0.00	Other	50	9
582	MAC.LAM.perivascular_angiocrine	1.69e-03	Nonsignificant	—	0.00	Other	53	138
583	ASTRO.stress_mito	1.59e-03	Nonsignificant	1.00	1.07	Other	47	110
584	MG.phagocytic_APC	1.58e-03	Nonsignificant	0.89	0.71	Other	25	8
585	MAC.LAM.anti_inflammatory	1.53e-03	Nonsignificant	0.96	0.96	Other	86	132
586	MAC.kupffer.tolerogenic	1.50e-03	Nonsignificant	—	0.00	Other	45	49
587	EPI.ileal_goblet.stress_metallothionein	1.49e-03	Nonsignificant	—	0.10	Other	4	11
588	MAC.resident_repair.ECM_stromal_crosstalk	1.47e-03	Nonsignificant	0.87	0.81	Other	95	158
589	EPI.bile_duct_cholangiocyte.inflammatory_APC	1.45e-03	Nonsignificant	—	0.00	Other	2	0
590	MEL.mature_oxidative_traffic	1.39e-03	Nonsignificant	0.93	0.81	Other	247	285
591	EC.heart_remodeling.translation_boost	1.21e-03	Nonsignificant	—	0.00	Other	0	0
592	EPI.ileal_goblet.baseline	1.17e-03	Nonsignificant	0.79	0.73	Other	16	2
593	ASTRO.immature_lipid	1.14e-03	Nonsignificant	1.00	0.93	Other	23	113
594	EPI.endocervical_secretory.secretory_translocon	1.01e-03	Nonsignificant	—	0.00	Other	0	0
595	EC.lymphatic.valve	9.63e-04	Nonsignificant	—	0.00	Other	0	0
596	CM.osmoprotection	8.97e-04	Nonsignificant	0.77	1.08	Other	34	57
597	HEP.periportal_metabolic.apolipoprotein_secretory	8.30e-04	Nonsignificant	1.00	0.82	Other	43	110
598	CM.inflammatory	8.03e-04	Nonsignificant	—	1.62	Other	0	0
599	MAC.resident_cardiac.inflammatory_reparative	6.78e-04	Nonsignificant	0.31	1.17	Other	31	96
600	MAC.MDM.LAM_like	6.57e-04	Nonsignificant	0.96	1.01	Other	12	14
601	DC.cDC2.proliferative	6.48e-04	Nonsignificant	—	0.00	Other	39	71
602	NEU.INH_VIP.canonical_disinhibitory	6.44e-04	Nonsignificant	1.00	0.23	Other	59	38
603	T.MAIT.stress	5.49e-04	Nonsignificant	—	0.72	Other	0	0
604	NEU.EXC_CT.Ca2_signaling	5.16e-04	Nonsignificant	—	0.00	Other	68	17
605	EC.heart_remodeling.activated_acute	5.06e-04	Nonsignificant	0.72	0.91	Other	102	186
606	DC.cDC2.tolerogenic_regulatory	4.54e-04	Nonsignificant	1.00	0.47	Other	44	4
607	GRANU.neutrophil.primed_degranulation	4.48e-04	Nonsignificant	—	0.90	Other	0	0
608	T.gamma_delta.central_memory	3.84e-04	Nonsignificant	1.00	0.38	Other	460	919
609	T.MAIT.quiescent	3.70e-04	Nonsignificant	0.96	0.85	Other	100	5
610	EPI.pancreatic_ductal_bicarbonate.baseline	3.65e-04	Nonsignificant	0.94	0.82	Other	11	42
611	CHOND.pro_inflammatory	3.22e-04	Nonsignificant	1.00	0.77	Other	181	351
612	MAC.MDM.complement_resolving	3.09e-04	Nonsignificant	0.96	0.69	Other	440	860
613	MAC.resident_iron.heme_recycling	2.92e-04	Nonsignificant	—	0.00	Other	30	37
614	ASTRO.A2_reactive	2.76e-04	Nonsignificant	1.00	0.81	Other	10	37
615	EPI.pancreatic_ductal_bicarbonate.inflammatory	2.74e-04	Nonsignificant	0.82	1.14	Other	14	32
616	EPI.pancreatic_acinar.adhesion_remodeling	2.70e-04	Nonsignificant	1.00	0.39	Other	210	784
617	SKM.type_1_slow.glycolytic	2.65e-04	Nonsignificant	0.17	1.18	Other	362	647
618	MAC.resident_repair.stress_iron	2.28e-04	Nonsignificant	0.85	0.88	Other	48	97
619	MAC.MDM.APC_dendritic	2.24e-04	Nonsignificant	0.96	0.82	Other	48	15
620	MAC.kupffer.fibrogenic	2.14e-04	Nonsignificant	—	0.00	Other	0	0
621	EPI.alveolar_type_2.injury_primed	2.09e-04	Nonsignificant	0.65	1.02	Other	434	245
622	MAC.LAM.lipid_phagocytosis	2.03e-04	Nonsignificant	0.96	0.91	Other	369	328
623	NEU.EXC_SYT2.nuclear_reg	1.85e-04	Nonsignificant	—	0.00	Other	0	0
624	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	1.66e-04	Nonsignificant	0.94	0.81	Other	219	533
625	EPI.lung_club_secretory.ciliogenesis_axoneme	1.59e-04	Nonsignificant	—	0.00	Other	0	0
626	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.42e-04	Nonsignificant	—	0.85	Other	0	0
627	EPI.extrahepatic_cholangiocyte.mucin_secretory	1.32e-04	Nonsignificant	—	0.73	Other	0	0
628	EPI.alveolar_type_2.stress_response	1.13e-04	Nonsignificant	0.99	0.67	Other	675	1,562
629	ASTRO.A1_reactive	1.01e-04	Nonsignificant	1.00	0.55	Other	433	394
630	EPI.ileal_enterocyte_crypt.secretory_precursor	9.84e-05	Nonsignificant	—	0.00	Other	0	0
631	T.MAIT.vesicle	8.50e-05	Nonsignificant	0.96	0.66	Other	37	65
632	MONO.CD14.cord_tolerance	8.11e-05	Nonsignificant	1.00	0.14	Other	864	753
633	MEL.stress_glucocorticoid	8.09e-05	Nonsignificant	0.93	0.46	Other	11	34
634	EPI.lung_multiciliated.mature_motile_cilia	7.38e-05	Nonsignificant	—	1.53	Other	0	0
635	GRANU.neutrophil.antiviral_endotoxin	5.61e-05	Nonsignificant	—	0.00	Other	0	0
636	EPI.hepatic_ductular_cholangiocyte.stress	5.45e-05	Nonsignificant	—	1.32	Other	0	0
637	NEU.EXC_CT.Ca2_sensor	5.41e-05	Nonsignificant	—	0.00	Other	0	0
638	MAC.LAM.antimicrobial	5.40e-05	Nonsignificant	0.99	0.54	Other	389	93
639	CM.oxidative_phospho	4.99e-05	Nonsignificant	1.00	1.01	Other	266	792
640	GRNLSA.p53_damage	4.80e-05	Nonsignificant	—	0.00	Other	13	10
641	CHOND.activated_fibro_like	4.56e-05	Nonsignificant	1.00	0.44	Other	531	188
642	EPI.renal_distal_tubule.ion_transport	4.33e-05	Nonsignificant	—	0.00	Other	0	0
643	EC.liver_sinusoidal.remodeling_lipotoxicity	4.23e-05	Nonsignificant	—	0.00	Other	90	58
644	EPI.skin_keratinocyte_basal.spinous_transition	3.54e-05	Nonsignificant	—	0.00	Other	0	0
645	ASTRO.homeostatic	3.23e-05	Nonsignificant	1.00	0.39	Other	200	431
646	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	3.09e-05	Nonsignificant	—	0.42	Other	0	0
647	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.04e-05	Nonsignificant	—	0.16	Other	5	3
648	CM.mito_proteostasis	2.26e-05	Nonsignificant	1.00	1.01	Other	329	29
649	CM.mechano_activated	2.16e-05	Nonsignificant	1.00	0.95	Other	205	134
650	CM.translation_boost_RPL	1.57e-05	Nonsignificant	1.00	0.99	Other	129	1
651	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.39e-05	Nonsignificant	—	0.22	Other	0	0
652	EPI.pancreatic_ductal_bicarbonate.activated	1.27e-05	Nonsignificant	0.94	0.63	Other	10	7
653	GRANU.neutrophil.tissue_patrolling	1.25e-05	Nonsignificant	—	0.00	Other	0	0
654	CM.sarcomere_actin_interface	1.09e-05	Nonsignificant	1.00	0.95	Other	450	78
655	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	9.45e-06	Nonsignificant	—	0.00	Other	0	0
656	MAC.alveolar.capillary_interacting	9.39e-06	Nonsignificant	0.18	1.24	Other	113	181
657	MAC.resident_cardiac.phagocytic_homeostasis	7.73e-06	Nonsignificant	1.00	0.38	Other	564	1,221
658	EPI.skin_keratinocyte_basal.transit_amplifying	7.33e-06	Nonsignificant	—	0.00	Other	0	0
659	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	7.01e-06	Nonsignificant	—	0.00	Other	49	237
660	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	6.98e-06	Nonsignificant	—	0.73	Other	0	0
661	EPI.salivary_mucous_acinar.baseline	6.33e-06	Nonsignificant	—	—	Other	394	683
662	SKM.type_1_slow.contractile	5.31e-06	Nonsignificant	1.00	0.65	Other	596	8
663	MAC.kupffer.metabolic	4.39e-06	Nonsignificant	—	0.00	Other	25	36
664	ADIPO.inflammatory	3.80e-06	Nonsignificant	—	0.00	Other	0	0
665	MAC.proliferating.stress	3.29e-06	Nonsignificant	—	0.00	Other	87	136
666	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	2.78e-06	Nonsignificant	0.92	0.57	Other	449	1,034
667	EPI.lung_multiciliated.baseline	2.59e-06	Nonsignificant	—	0.51	Other	0	7
668	HEP.periportal_metabolic.inflammatory_activated	1.37e-06	Nonsignificant	1.00	0.42	Other	712	1,610
669	SKM.type_1_slow.oxidative	1.34e-06	Nonsignificant	1.00	0.47	Other	802	251
670	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	6.81e-07	Nonsignificant	—	0.00	Other	0	0
671	MAC.alveolar.stress_metabolic	6.66e-07	Nonsignificant	0.79	1.03	Other	116	148
672	MAC.alveolar.inflammatory	5.17e-07	Nonsignificant	0.79	0.98	Other	208	312
673	GRNLSA.angiocrine_mechanosensory	5.16e-07	Nonsignificant	—	0.00	Other	0	0
674	MAC.alveolar.lipid_autophagy	4.17e-07	Nonsignificant	—	0.00	Other	35	44
675	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	3.83e-07	Nonsignificant	—	0.31	Other	6	9
676	EPI.lung_multiciliated.stress	3.15e-07	Nonsignificant	—	0.00	Other	67	165
677	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.36e-07	Nonsignificant	—	0.00	Other	0	0
678	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	2.28e-07	Nonsignificant	—	0.00	Other	0	0
679	EPI.hepatic_ductular_cholangiocyte.polarity	1.79e-07	Nonsignificant	—	0.16	Other	0	0
680	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.73e-07	Nonsignificant	—	0.00	Other	0	0
681	EPI.extrahepatic_cholangiocyte.barrier_interface	1.40e-07	Nonsignificant	—	0.00	Other	0	0
682	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	1.27e-07	Nonsignificant	—	0.00	Other	0	0
683	CM.anti_inflammatory	1.15e-07	Nonsignificant	1.00	0.77	Other	424	1,503
684	MAC.alveolar.biosynthetic_sterol_heme	3.73e-08	Nonsignificant	0.91	0.85	Other	347	40
685	EPI.hepatic_ductular_cholangiocyte.ion_transport	2.55e-08	Nonsignificant	—	0.00	Other	0	0
686	EPI.hepatic_ductular_cholangiocyte.secretory_transport	1.13e-08	Nonsignificant	—	0.00	Other	0	0
687	MAC.alveolar.scavenging_endocytic	8.50e-10	Nonsignificant	—	0.00	Other	140	283
688	CM.translation_boost_RPS	3.31e-10	Nonsignificant	1.00	0.56	Other	69	16

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

0 unique genes. Showing 0–0. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.