Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000082 · All tissues

Anaemias: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Anaemia

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	5.94	Significant	1.13e-22	1.16	Other	0	0
2	chondrocyte	5.15	Nominal	0.01	1.12	Other	548	1,069
3	endothelial_cell	3.61	Nominal	2.16e-19	1.13	Other	373	974
4	epithelial_cell	2.94	Nonsignificant	2.14e-05	1.05	Other	24	47
5	neuron	2.73	Nonsignificant	1.00	1.00	Other	330	1,328
6	haematopoietic_progenitor_cell	1.24	Nonsignificant	1.00	0.95	Other	262	502
7	smooth_muscle_cell	1.23	Nonsignificant	1.00	0.93	Other	27	139
8	monocyte	1.12	Nonsignificant	1.00	0.96	Other	2,176	3,871
9	pericyte	1.10	Nonsignificant	1.00	0.97	Other	128	517
10	melanocyte	0.99	Nonsignificant	1.00	0.89	Other	97	309
11	granulocyte	0.81	Nonsignificant	1.00	0.98	Other	5	6
12	hepatocyte	0.74	Nonsignificant	1.00	0.89	Other	1,515	3,822
13	platelet	0.52	Nonsignificant	—	0.61	Other	85	104
14	oligodendrocyte_precursor_cell	0.45	Nonsignificant	1.00	0.85	Other	461	1,454
15	granulosa_cell	0.28	Nonsignificant	1.00	0.82	Other	293	670
16	mesothelial_cell	0.15	Nonsignificant	1.00	0.74	Other	6	36
17	dendritic_cell	0.15	Nonsignificant	1.00	0.79	Other	496	724
18	adipocyte	0.14	Nonsignificant	1.00	0.92	Other	33	111
19	thymocyte	0.13	Nonsignificant	1.00	0.81	Other	168	512
20	schwann_cell	0.12	Nonsignificant	1.00	0.77	Other	10	57
21	innate_lymphoid_cell_2	0.04	Nonsignificant	1.00	0.87	Other	3	8
22	fibroblast	0.04	Nonsignificant	1.00	0.73	Other	184	826
23	macrophage	0.03	Nonsignificant	1.00	0.63	Other	813	1,732
24	T_cell	0.03	Nonsignificant	1.00	0.53	Other	470	959
25	astrocyte	0.02	Nonsignificant	1.00	0.64	Other	256	1,203
26	adipose_stem_and_progenitor_cell	0.02	Nonsignificant	1.00	0.63	Other	327	954
27	muscle_stem_cell	0.01	Nonsignificant	1.00	0.51	Other	7	27
28	oligodendrocyte	6.76e-03	Nonsignificant	1.00	0.49	Other	385	1,507
29	natural_killer_cell	6.73e-03	Nonsignificant	1.00	0.51	Other	1,204	2,052
30	plasma_cell	6.56e-03	Nonsignificant	1.00	0.55	Other	17	24
31	microglia	2.03e-03	Nonsignificant	1.00	0.42	Other	61	129
32	B_cell	1.11e-03	Nonsignificant	1.00	0.42	Other	356	694
33	cardiomyocyte	1.35e-04	Nonsignificant	1.00	0.47	Other	533	2,045
34	skeletal_muscle_cell	5.56e-08	Nonsignificant	1.00	0.14	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_ductal_mucinous	19.38	Significant	0.03	1.38	Relevant	219	430
2	EPI.renal_principal_cell	18.36	Significant	1.55e-06	1.51	Specific	207	403
3	EPI.intrahepatic_cholangiocyte_transport	12.20	Significant	—	1.54	Relevant	12	42
4	NEU.INH_VIP	10.35	Significant	5.19e-15	1.75	Specific	241	366
5	EPI.renal_thick_ascending_limb	9.37	Significant	1.34e-07	1.40	Specific	453	1,153
6	EPI.renal_proximal_tubule	8.89	Significant	0.01	1.38	Specific	525	806
7	EPI.intrahepatic_cholangiocyte_defense	8.06	Significant	—	1.18	Relevant	8	13
8	EPI.renal_distal_tubule	7.51	Significant	1.00	1.20	Relevant	133	361
9	EPI.pancreatic_acinar	6.22	Significant	2.29e-04	1.27	Other	429	1,475
10	EC.arterial	5.96	Significant	6.19e-19	2.02	Other	356	885
11	IPSC.induced_pluripotent_stem_cell	5.94	Significant	—	—	Other	0	0
12	EPI.renal_intercalated_cell_type_A	5.42	Nominal	1.00	1.05	Other	67	142
13	CHOND.chondrocyte	5.15	Nominal	—	—	Other	519	730
14	EC.liver_sinusoidal	4.94	Nominal	4.57e-05	1.87	Other	1,083	1,925
15	EPI.extrahepatic_cholangiocyte	4.08	Nominal	—	0.62	Other	37	71
16	EPI.renal_immature_ureteric_bud	3.94	Nominal	1.00	1.08	Other	217	569
17	EPI.pancreatic_ductal_bicarbonate	3.83	Nominal	1.00	1.05	Other	131	548
18	EPI.renal_intercalated_cell_type_B	3.65	Nominal	—	0.73	Other	6	7
19	EC.heart_remodeling	3.36	Nominal	0.82	1.03	Other	569	1,594
20	EC.capillary	3.33	Nominal	1.00	0.90	Other	514	1,635
21	EPI.endocervical_secretory	3.23	Nominal	—	0.73	Other	0	0
22	NEU.INH_LAMP5	2.86	Nonsignificant	0.52	1.25	Other	263	532
23	EPI.cervical_suprabasal	2.81	Nonsignificant	—	0.60	Other	14	50
24	EC.venous	2.62	Nonsignificant	1.00	0.40	Other	516	1,387
25	EPI.ectocervical_granular	2.44	Nonsignificant	—	0.42	Other	11	23
26	EPI.pancreatic_ductal_perivascular	2.39	Nonsignificant	1.00	0.95	Other	4	30
27	HEP.acute_phase	2.23	Nonsignificant	2.87e-44	1.66	Other	1,441	3,641
28	EPI.ileal_enterocyte_crypt	2.14	Nonsignificant	1.00	0.89	Other	67	113
29	GRANU.neutrophil	2.06	Nonsignificant	1.90e-03	1.45	Other	1,235	2,649
30	EPI.pancreatic_ductal_progenitor	1.86	Nonsignificant	1.00	0.90	Other	234	873
31	EPI.ileal_bile_transport	1.85	Nonsignificant	1.00	0.89	Other	61	93
32	EPI.lung_multiciliated	1.78	Nonsignificant	1.00	0.87	Other	16	49
33	EPI.skin_sweat_duct_keratinocyte	1.72	Nonsignificant	1.00	0.84	Other	146	301
34	EPI.alveolar_type_2	1.41	Nonsignificant	1.00	0.80	Other	813	1,853
35	MONO.CD14	1.33	Nonsignificant	7.21e-40	1.63	Other	2,294	4,139
36	NEU.EXC_IT	1.30	Nonsignificant	1.00	0.65	Other	411	192
37	FIB.lung_alveolar	1.28	Nonsignificant	—	2.42	Other	6	15
38	NEU.EXC_SYT2	1.26	Nonsignificant	—	0.00	Other	40	77
39	HPC.haematopoietic_progenitor_cell	1.24	Nonsignificant	—	—	Other	211	370
40	SMC.smooth_muscle_cell	1.23	Nonsignificant	—	—	Other	20	101
41	EPI.colonic_enteroendocrine	1.22	Nonsignificant	—	0.06	Other	1	1
42	EPI.tracheal_suprabasal	1.20	Nonsignificant	1.00	0.73	Other	29	56
43	EPI.skin_appendage_keratinocyte	1.13	Nonsignificant	1.00	0.66	Other	87	222
44	EPI.lung_club_secretory	1.10	Nonsignificant	1.00	0.78	Other	5	14
45	PERI.pericyte	1.10	Nonsignificant	—	—	Other	117	0
46	EPI.pancreatic_islet	1.09	Nonsignificant	1.00	0.61	Other	52	132
47	MEL.melanocyte	0.99	Nonsignificant	—	—	Other	79	242
48	NEU.EXC_NTNG1	0.97	Nonsignificant	—	0.00	Other	0	0
49	EPI.skin_interfollicular_spinous	0.96	Nonsignificant	1.00	0.65	Other	260	563
50	EPI.skin_keratinocyte_proliferating	0.96	Nonsignificant	1.00	0.64	Other	47	76
51	EPI.bile_duct_cholangiocyte	0.80	Nonsignificant	1.00	0.60	Other	37	60
52	EPI.hepatic_ductular_cholangiocyte	0.77	Nonsignificant	1.00	0.49	Other	83	243
53	EPI.ileal_enterocyte_absorptive	0.77	Nonsignificant	1.00	0.56	Other	118	338
54	DC.pDC	0.74	Nonsignificant	3.64e-04	1.27	Other	496	1,028
55	EPI.ileal_goblet	0.68	Nonsignificant	1.00	0.64	Other	181	432
56	EPI.tracheal_basal	0.56	Nonsignificant	1.00	0.57	Other	398	1,120
57	EPI.skin_keratinocyte_basal	0.53	Nonsignificant	—	0.00	Other	13	26
58	EPI.esophageal_suprabasal	0.52	Nonsignificant	1.00	0.53	Other	158	404
59	PLAT.platelet	0.52	Nonsignificant	—	0.00	Other	38	53
60	FIB.transitioning	0.51	Nonsignificant	0.83	1.13	Other	172	497
61	EPI.salivary_duct_ion_transport	0.46	Nonsignificant	1.00	0.51	Other	5	11
62	OPC.oligodendrocyte_precursor_cell	0.45	Nonsignificant	—	—	Other	413	1,269
63	EPI.salivary_mucous_acinar	0.41	Nonsignificant	1.00	0.49	Other	639	1,189
64	NEU.INH_PVALB	0.33	Nonsignificant	1.00	0.19	Other	193	183
65	EPI.gastric_foveolar	0.32	Nonsignificant	—	0.00	Other	0	0
66	EPI.skin_hair_follicle_companion	0.29	Nonsignificant	—	0.00	Other	8	12
67	GRNLSA.granulosa_cell	0.28	Nonsignificant	—	—	Other	257	0
68	EC.lymphatic	0.22	Nonsignificant	1.00	0.00	Other	630	998
69	HEP.canalicular_transport	0.21	Nonsignificant	1.00	0.37	Other	1,290	3,434
70	EPI.alveolar_type_1	0.21	Nonsignificant	1.00	0.45	Other	26	101
71	NEU.EXC_CT	0.21	Nonsignificant	1.00	0.10	Other	362	384
72	EPI.skin_hair_follicle_bulge	0.20	Nonsignificant	1.00	0.37	Other	51	178
73	HEP.periportal_metabolic	0.20	Nonsignificant	1.00	0.46	Other	1,750	4,427
74	EPI.colonic_tuft	0.20	Nonsignificant	—	0.00	Other	7	24
75	T.CD4_Trm	0.16	Nonsignificant	0.07	1.31	Other	176	363
76	EPI.salivary_duct_excretory	0.15	Nonsignificant	1.00	0.34	Other	85	180
77	MESO.mesothelial_cell	0.15	Nonsignificant	—	—	Other	2	18
78	EPI.skin_keratinocyte_progenitor	0.15	Nonsignificant	—	0.00	Other	0	3
79	ADIPO.adipocyte	0.14	Nonsignificant	—	—	Other	20	62
80	EPI.colonocyte	0.14	Nonsignificant	1.00	0.24	Other	294	815
81	FIB.reticular	0.13	Nonsignificant	0.83	1.05	Other	19	87
82	THYMO.thymocyte	0.13	Nonsignificant	—	—	Other	163	495
83	SCHWN.schwann_cell	0.12	Nonsignificant	—	—	Other	7	33
84	HEP.pericentral_lipoprotein	0.12	Nonsignificant	—	0.00	Other	0	0
85	EPI.skin_sebaceous_duct_luminal	0.12	Nonsignificant	1.00	0.29	Other	100	249
86	FIB.suburothelial	0.12	Nonsignificant	0.83	1.07	Other	122	432
87	EPI.salivary_myoepithelial	0.11	Nonsignificant	1.00	0.31	Other	191	714
88	DC.cDC1	0.11	Nonsignificant	0.94	0.98	Other	55	112
89	EPI.esophageal_basal	0.11	Nonsignificant	1.00	0.33	Other	4	10
90	FIB.perivascular_interface	0.10	Nonsignificant	0.83	1.10	Other	0	0
91	T.CD4_Tfh	0.09	Nonsignificant	0.26	1.21	Other	47	45
92	GRANU.MAST	0.08	Nonsignificant	1.00	0.00	Other	5	6
93	FIB.barrier_purinergic	0.08	Nonsignificant	—	1.29	Other	1	3
94	MAC.alveolar	0.07	Nonsignificant	0.26	1.21	Other	1,432	3,122
95	DC.mig	0.07	Nonsignificant	—	0.46	Other	89	156
96	T.CD4_Treg	0.06	Nonsignificant	0.31	1.14	Other	244	511
97	ILC2.innate_lymphoid_cell_2	0.04	Nonsignificant	—	—	Other	2	0
98	MAC.resident_iron	0.04	Nonsignificant	0.93	0.98	Other	16	21
99	MAC.LAM	0.04	Nonsignificant	0.93	1.03	Other	914	2,064
100	FIB.hepatic_stellate_cell	0.04	Nonsignificant	—	1.01	Other	64	252
101	T.CD4_transitional	0.04	Nonsignificant	0.26	1.17	Other	48	110
102	EPI.tracheal_submucosal_gland	0.04	Nonsignificant	—	0.00	Other	0	0
103	MAC.proliferating	0.03	Nonsignificant	0.93	0.98	Other	87	253
104	FIB.skin_tenogenic	0.03	Nonsignificant	—	0.96	Other	108	227
105	MONO.CD16	0.03	Nonsignificant	1.00	0.26	Other	1,304	1,835
106	T.MAIT	0.03	Nonsignificant	0.77	1.02	Other	469	855
107	FIB.skin_sheath	0.03	Nonsignificant	0.87	1.01	Other	49	118
108	T.CD4_naive	0.03	Nonsignificant	0.77	1.00	Other	399	866
109	FIB.interstitial	0.03	Nonsignificant	0.88	0.99	Other	288	940
110	EPI.salivary_intercalated_defense	0.02	Nonsignificant	1.00	0.21	Other	81	161
111	EPI.skin_follicular_keratinizing	0.02	Nonsignificant	1.00	0.19	Other	30	81
112	T.CD4_Th2	0.02	Nonsignificant	—	0.92	Other	1	2
113	ASTRO.astrocyte	0.02	Nonsignificant	—	—	Other	228	1,111
114	ASPC.adipose_stem_and_progenitor_cell	0.02	Nonsignificant	—	—	Other	324	930
115	MAC.MDM	0.02	Nonsignificant	0.93	0.96	Other	623	986
116	DC.cDC2	0.02	Nonsignificant	1.00	0.00	Other	1,189	1,793
117	PC.IgG_systemic	0.02	Nonsignificant	0.51	1.09	Other	41	60
118	FIB.skin_papillary	0.02	Nonsignificant	—	0.81	Other	0	0
119	T.CD4_Tem	0.01	Nonsignificant	0.77	1.01	Other	365	697
120	FIB.tracheal_subepithelial	0.01	Nonsignificant	—	0.64	Other	0	0
121	T.gamma_delta	0.01	Nonsignificant	1.00	0.79	Other	588	1,078
122	T.CD8_Trm	0.01	Nonsignificant	0.26	1.18	Other	211	346
123	T.CD8_Tem	0.01	Nonsignificant	0.76	1.02	Other	1,083	1,857
124	MAC.resident_repair	0.01	Nonsignificant	0.93	0.96	Other	796	1,426
125	MUSC.muscle_stem_cell	0.01	Nonsignificant	—	—	Other	4	18
126	T.CD8_transitional	9.71e-03	Nonsignificant	1.00	0.94	Other	497	932
127	MAC.kupffer	8.08e-03	Nonsignificant	0.93	0.92	Other	189	530
128	T.CD4_cytotoxic	7.94e-03	Nonsignificant	1.00	0.76	Other	855	1,493
129	B.age_associated	7.30e-03	Nonsignificant	0.97	1.05	Other	207	350
130	OLG.oligodendrocyte	6.76e-03	Nonsignificant	—	—	Other	384	1,397
131	NK.natural_killer_cell	6.73e-03	Nonsignificant	—	—	Other	1,204	2,045
132	T.CD4_Tcm	6.20e-03	Nonsignificant	1.00	0.75	Other	494	988
133	FIB.barrier_secretory	5.70e-03	Nonsignificant	0.83	1.08	Other	81	228
134	PC.IgA_muocsal	5.13e-03	Nonsignificant	0.99	0.82	Other	18	31
135	FIB.skin_neurosecretory	4.84e-03	Nonsignificant	—	0.56	Other	0	0
136	FIB.adventitial	3.61e-03	Nonsignificant	1.00	0.59	Other	268	1,447
137	T.CD4_Th17	3.58e-03	Nonsignificant	1.00	0.84	Other	421	794
138	EPI.salivary_serous_acinar	3.37e-03	Nonsignificant	1.00	0.07	Other	233	531
139	MG.microglia	2.03e-03	Nonsignificant	—	—	Other	49	0
140	T.CD8_Tcm	1.38e-03	Nonsignificant	1.00	0.55	Other	460	926
141	B.naive	1.08e-03	Nonsignificant	0.97	0.99	Other	307	595
142	T.CD8_naive	1.07e-03	Nonsignificant	1.00	0.64	Other	317	708
143	B.memory	8.39e-04	Nonsignificant	0.97	0.98	Other	442	882
144	EPI.thymic_medullary	3.01e-04	Nonsignificant	1.00	0.15	Other	26	133
145	CM.cardiomyocyte	1.35e-04	Nonsignificant	—	—	Other	524	2,032
146	FIB.neurolectin_mucosa	2.21e-05	Nonsignificant	1.00	0.23	Other	133	394
147	MAC.resident_cardiac	1.61e-05	Nonsignificant	1.00	0.12	Other	485	1,074
148	MAC.microglia_like	1.21e-05	Nonsignificant	1.00	0.26	Other	124	179
149	B.germinal_center	6.07e-07	Nonsignificant	0.97	0.57	Other	233	655
150	SKM.type_2_fast	9.51e-08	Nonsignificant	0.53	1.04	Other	972	2,639
151	SKM.type_1_slow	2.32e-09	Nonsignificant	0.53	1.02	Other	923	2,478
152	EPI.thymic_cortical	5.54e-10	Nonsignificant	1.00	0.06	Other	442	824

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	24.50	Significant	0.04	1.83	Specific	449	1,034
2	EPI.renal_principal_cell.activated_acute	23.36	Significant	0.17	1.77	Relevant	29	59
3	EPI.renal_principal_cell.inflammatory	22.22	Significant	0.17	1.70	Relevant	74	157
4	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	21.22	Significant	—	0.10	Relevant	0	0
5	NEU.INH_VIP.matrix	20.96	Significant	—	1.44	Relevant	24	77
6	NEU.INH_VIP.cannabinoid	18.50	Significant	—	1.25	Relevant	0	0
7	EPI.renal_principal_cell.intercalated_like	16.63	Significant	1.00	0.74	—	63	66
8	EPI.renal_principal_cell.injury_repair	15.88	Significant	1.00	0.57	—	26	9
9	EPI.renal_distal_tubule.immune_modulatory	15.68	Significant	—	1.16	Relevant	0	0
10	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	15.38	Significant	—	1.15	—	0	0
11	EPI.renal_thick_ascending_limb.barrier_repair	14.88	Significant	0.03	1.98	Specific	141	284
12	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	13.44	Significant	—	0.32	—	0	0
13	EPI.renal_principal_cell.canonical_vasopressin	13.33	Significant	1.00	0.06	—	2	0
14	NEU.INH_VIP.opioid	13.07	Significant	—	0.44	—	50	9
15	NEU.INH_VIP.develop_niche	12.76	Significant	—	0.63	Relevant	0	0
16	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	12.24	Significant	—	0.00	—	0	0
17	EPI.renal_intercalated_cell_type_A.PC_transitional	11.88	Significant	—	0.93	Specific	203	407
18	IPSC.mesendo_primed	11.56	Significant	1.44e-19	2.07	Relevant	0	0
19	NEU.INH_VIP.excitatory_coupled	10.37	Significant	—	0.36	—	13	0
20	IPSC.stromal_primed	10.25	Significant	2.38e-05	1.64	Relevant	0	0
21	EC.liver_sinusoidal.secretory_lipoprotein	10.21	Significant	0.01	1.62	Specific	120	70
22	CHOND.pro_inflammatory	9.75	Significant	1.65e-06	2.46	Specific	181	351
23	NEU.INH_VIP.canonical_disinhibitory	9.43	Significant	0.79	0.69	—	59	38
24	EPI.pancreatic_acinar.metabolic_onecarbon	9.30	Significant	8.79e-07	2.27	Specific	287	328
25	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	9.24	Significant	—	0.00	—	0	0
26	EPI.renal_proximal_tubule.detox_antioxidant	9.16	Significant	0.26	1.69	—	394	77
27	EPI.renal_thick_ascending_limb.remodeling	8.81	Significant	0.93	0.87	—	152	92
28	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	8.59	Significant	—	0.00	Relevant	0	0
29	EPI.renal_proximal_tubule.onecarbon_peroxisome	8.53	Significant	0.92	0.22	Relevant	58	89
30	EPI.renal_thick_ascending_limb.canonical_salt_transporter	8.33	Significant	0.93	0.74	—	322	317
31	NEU.INH_VIP.nuclear_reg	8.01	Significant	—	0.00	Relevant	20	4
32	IPSC.axial_identity_primed	8.00	Significant	2.67e-03	1.44	Relevant	0	0
33	EPI.renal_thick_ascending_limb.cation_flux	7.88	Significant	0.93	0.86	Relevant	57	95
34	EC.arterial.metabolic	7.82	Significant	0.04	1.78	Specific	195	159
35	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	7.74	Significant	—	0.00	—	0	0
36	EPI.pancreatic_acinar.adhesion_remodeling	7.72	Significant	0.47	1.21	Relevant	210	784
37	EC.liver_sinusoidal.stress	7.72	Significant	—	0.64	Relevant	413	158
38	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	7.59	Significant	—	0.00	—	0	0
39	EPI.renal_distal_tubule.ion_transport	7.38	Significant	—	0.26	—	0	0
40	NEU.INH_VIP.LAMP5_hybrid	7.23	Significant	—	0.00	—	1	9
41	EC.arterial.inflammatory	7.22	Significant	0.51	1.27	Relevant	63	50
42	EC.arterial.elastic	6.77	Significant	0.06	1.72	Specific	22	45
43	EPI.pancreatic_acinar.baseline	6.58	Significant	1.00	0.86	Relevant	274	163
44	EPI.renal_thick_ascending_limb.salt_sensing	6.43	Significant	0.99	0.10	—	73	103
45	EC.arterial.angiogenic_tip	6.42	Significant	—	0.06	Relevant	30	37
46	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	6.34	Significant	0.17	1.66	Other	219	533
47	EPI.renal_distal_tubule.repair	6.24	Significant	—	0.00	Other	34	102
48	EC.venous.remodeling_stalk	6.00	Significant	1.44e-06	2.47	Specific	559	566
49	IPSC.proliferative	5.86	Significant	1.00	1.00	Relevant	0	0
50	EC.arterial.mito_contact	5.77	Significant	0.82	0.90	Other	14	5
51	EC.heart_remodeling.remodeling_secretory	5.69	Significant	0.02	1.51	Other	605	1,341
52	NEU.INH_VIP.regulatory_remodeling	5.57	Significant	—	0.00	Other	6	1
53	EC.liver_sinusoidal.inflammatory	5.52	Significant	—	0.38	Other	223	154
54	EC.arterial.homeostatic	5.43	Nominal	0.59	1.09	Other	24	3
55	EC.arterial.arteriole_interface	5.37	Nominal	0.59	1.14	Other	31	12
56	CHOND.activated_fibro_like	5.14	Nominal	0.25	1.28	Other	531	188
57	EC.arterial.arteriole_gas_exchange	4.94	Nominal	0.99	0.65	Other	238	131
58	EPI.pancreatic_ductal_bicarbonate.stress	4.86	Nominal	—	0.00	Other	12	33
59	EC.capillary.angiogenic_tip	4.77	Nominal	8.76e-03	2.07	Other	186	218
60	EPI.renal_immature_ureteric_bud.osmoprotective	4.65	Nominal	0.09	1.68	Other	126	44
61	NEU.INH_VIP.serotonergic	4.61	Nominal	—	0.00	Other	9	2
62	EPI.extrahepatic_cholangiocyte.mucin_secretory	4.61	Nominal	—	0.42	Other	0	0
63	EC.heart_remodeling.capillary_metabolic	4.14	Nominal	0.03	1.72	Other	54	414
64	EPI.endocervical_secretory.squamous_barrier	4.11	Nominal	—	0.67	Other	0	0
65	CHOND.remodeling	4.06	Nominal	—	0.00	Other	5	0
66	EC.capillary.angiocrine	4.04	Nominal	0.14	1.51	Other	250	630
67	EPI.renal_distal_tubule.stress	3.88	Nominal	—	0.00	Other	0	0
68	CHOND.angiogenic	3.86	Nominal	—	0.00	Other	0	0
69	EPI.ectocervical_granular.immune_interact	3.82	Nominal	—	1.15	Other	0	0
70	EPI.pancreatic_ductal_bicarbonate.inflammatory	3.81	Nominal	0.71	1.10	Other	14	32
71	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	3.80	Nominal	0.71	1.22	Other	40	191
72	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	3.78	Nominal	—	0.54	Other	49	237
73	IPSC.stress	3.78	Nominal	1.00	0.58	Other	0	0
74	EC.arterial.ion_pump	3.74	Nominal	0.99	0.23	Other	3	2
75	EC.heart_remodeling.angiocrine	3.68	Nominal	0.73	1.08	Other	182	525
76	EPI.renal_intercalated_cell_type_B.baseline	3.65	Nominal	—	0.00	Other	3	1
77	EC.venous.cardiac_structural	3.62	Nominal	0.22	1.58	Other	102	229
78	EPI.cervical_suprabasal.inflammatory_repair	3.60	Nominal	—	0.73	Other	0	0
79	EPI.renal_intercalated_cell_type_A.acid_secretion	3.59	Nominal	0.98	0.23	Other	12	6
80	EPI.extrahepatic_cholangiocyte.barrier_interface	3.51	Nominal	—	0.00	Other	0	0
81	EC.capillary.migratory	3.46	Nominal	0.99	1.04	Other	181	509
82	EC.capillary.postcap_venule	3.39	Nominal	0.99	0.93	Other	355	261
83	EC.venous.quiescent_homeostatic	3.32	Nominal	0.27	1.35	Other	456	360
84	NEU.INH_LAMP5.exc_inh_balance	3.23	Nominal	—	0.58	Other	46	2
85	EPI.pancreatic_acinar.stress	3.18	Nominal	1.00	0.19	Other	28	28
86	EC.capillary.inflammatory	3.15	Nominal	0.99	0.68	Other	27	51
87	EC.capillary.baseline	3.13	Nominal	0.99	0.78	Other	246	560
88	NEU.INH_LAMP5.glial_interface	3.12	Nominal	—	0.26	Other	0	0
89	EPI.hepatic_ductular_cholangiocyte.ion_transport	3.06	Nominal	—	1.86	Other	0	0
90	CHOND.articular_collagen	2.99	Nonsignificant	1.00	7.15e-03	Other	551	266
91	EPI.ileal_enterocyte_crypt.proliferative_G2M	2.98	Nonsignificant	—	0.66	Other	19	54
92	IPSC.mesenchymal_primed	2.96	Nonsignificant	1.00	0.40	Other	0	0
93	HEP.acute_phase.complement_metabolic	2.95	Nonsignificant	1.53e-07	2.57	Other	1,423	3,464
94	IPSC.neural_primed	2.95	Nonsignificant	1.00	0.42	Other	0	0
95	EPI.pancreatic_ductal_bicarbonate.activated	2.92	Nonsignificant	0.88	0.74	Other	10	7
96	EPI.pancreatic_ductal_bicarbonate.baseline	2.82	Nonsignificant	0.95	0.41	Other	11	42
97	EPI.endocervical_secretory.secretory_translocon	2.80	Nonsignificant	—	0.00	Other	0	0
98	EPI.ectocervical_granular.proliferative_basal	2.77	Nonsignificant	—	0.32	Other	0	0
99	NEU.INH_LAMP5.rosehip	2.71	Nonsignificant	—	0.00	Other	0	0
100	EPI.pancreatic_acinar.quiet_dedifferentiation	2.69	Nonsignificant	1.00	0.24	Other	142	171
101	EPI.skin_sweat_duct_keratinocyte.proliferative_S	2.61	Nonsignificant	—	1.04	Other	0	0
102	EPI.colonic_enteroendocrine.Lcell_peptide	2.61	Nonsignificant	—	0.97	Other	0	0
103	NEU.EXC_SYT2.nuclear_reg	2.57	Nonsignificant	—	0.97	Other	0	0
104	EC.capillary.stress	2.54	Nonsignificant	0.99	0.34	Other	44	36
105	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	2.54	Nonsignificant	—	1.08	Other	0	0
106	EC.capillary.activated	2.53	Nonsignificant	0.99	0.83	Other	2	5
107	NEU.INH_VIP.enkephalinergic	2.47	Nonsignificant	—	0.00	Other	0	0
108	EPI.pancreatic_ductal_perivascular.protective_antioxidant	2.45	Nonsignificant	—	0.18	Other	11	69
109	EPI.lung_multiciliated.mature_motile_cilia	2.44	Nonsignificant	—	0.89	Other	0	0
110	EC.venous.activated	2.44	Nonsignificant	0.70	1.03	Other	247	752
111	EPI.pancreatic_acinar.inflammatory_regenerative	2.43	Nonsignificant	0.09	1.58	Other	25	113
112	EC.heart_remodeling.activated_acute	2.40	Nonsignificant	1.00	0.64	Other	102	186
113	EPI.ectocervical_granular.inflammatory	2.36	Nonsignificant	—	0.00	Other	0	0
114	HPC.MEP	2.35	Nonsignificant	0.46	1.11	Other	599	1,195
115	EPI.pancreatic_ductal_perivascular.baseline	2.35	Nonsignificant	0.57	0.90	Other	1	5
116	EC.heart_remodeling.translation_boost	2.32	Nonsignificant	—	0.00	Other	0	0
117	EC.venous.baseline	2.30	Nonsignificant	0.99	0.48	Other	346	807
118	EPI.skin_appendage_keratinocyte.transit_amplifying	2.29	Nonsignificant	—	1.44	Other	109	358
119	EPI.ileal_enterocyte_crypt.villus_transition	2.29	Nonsignificant	—	0.23	Other	7	10
120	EPI.ileal_enterocyte_crypt.proliferative_S	2.26	Nonsignificant	0.31	1.32	Other	4	2
121	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.21	Nonsignificant	—	1.01	Other	105	368
122	GRANU.neutrophil.tissue_patrolling	2.18	Nonsignificant	—	0.52	Other	0	0
123	GRANU.neutrophil.primed_degranulation	2.16	Nonsignificant	—	0.38	Other	0	0
124	EPI.ileal_enterocyte_crypt.baseline	2.10	Nonsignificant	0.31	1.32	Other	11	6
125	EC.venous.adipose_lipid	2.07	Nonsignificant	0.99	0.40	Other	254	476
126	EC.liver_sinusoidal.remodeling_lipotoxicity	2.05	Nonsignificant	—	0.00	Other	90	58
127	EPI.cervical_suprabasal.secretory_vesicle	2.03	Nonsignificant	—	0.00	Other	0	0
128	EPI.lung_multiciliated.baseline	2.01	Nonsignificant	—	0.51	Other	0	7
129	HEP.acute_phase.baseline	2.00	Nonsignificant	0.99	0.44	Other	946	19
130	NEU.INH_LAMP5.projecting	2.00	Nonsignificant	—	0.00	Other	0	0
131	EPI.ileal_bile_transport.absorptive_xenobiotic	1.99	Nonsignificant	0.12	1.73	Other	11	12
132	HEP.acute_phase.inflammatory	1.97	Nonsignificant	0.99	0.76	Other	382	649
133	EPI.skin_interfollicular_spinous.proliferative	1.96	Nonsignificant	—	2.19	Other	0	0
134	EPI.ileal_enterocyte_crypt.bile_transport	1.92	Nonsignificant	0.84	0.63	Other	2	0
135	HEP.acute_phase.complement_antiviral	1.91	Nonsignificant	0.99	0.56	Other	377	751
136	EPI.pancreatic_ductal_progenitor.ADM_like	1.90	Nonsignificant	—	0.16	Other	0	0
137	EPI.pancreatic_ductal_progenitor.baseline	1.88	Nonsignificant	0.46	0.99	Other	179	702
138	GRANU.neutrophil.antiviral_endotoxin	1.88	Nonsignificant	—	0.00	Other	0	0
139	EPI.renal_immature_ureteric_bud.defense_secretory	1.87	Nonsignificant	1.00	0.04	Other	45	76
140	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.86	Nonsignificant	—	0.28	Other	0	0
141	IPSC.midbrain_primed	1.82	Nonsignificant	1.00	0.26	Other	0	0
142	EPI.alveolar_type_2.injury_primed	1.80	Nonsignificant	2.42e-04	2.50	Other	434	245
143	IPSC.neuroendocrine_primed	1.79	Nonsignificant	—	0.00	Other	0	0
144	NEU.EXC_IT.callosal	1.72	Nonsignificant	0.16	1.68	Other	286	119
145	HPC.LMPP	1.67	Nonsignificant	0.46	1.11	Other	65	31
146	PERI.angiocrine	1.66	Nonsignificant	3.23e-04	2.08	Other	93	102
147	MONO.CD14.baseline	1.62	Nonsignificant	2.25e-05	1.23	Other	2,268	76
148	EPI.skin_interfollicular_spinous.stress_oxidative	1.60	Nonsignificant	—	1.16	Other	0	0
149	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.57	Nonsignificant	—	0.00	Other	43	26
150	NEU.EXC_IT.transitional	1.56	Nonsignificant	0.62	1.16	Other	237	142
151	SMC.activated	1.55	Nonsignificant	0.06	1.51	Other	2	5
152	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.54	Nonsignificant	—	0.87	Other	135	290
153	NEU.EXC_IT.guidance	1.54	Nonsignificant	0.18	1.51	Other	274	63
154	IPSC.mesodermal_primed	1.53	Nonsignificant	1.00	0.15	Other	0	0
155	HPC.MPP_IEG	1.53	Nonsignificant	0.46	1.25	Other	45	46
156	HEP.acute_phase.proliferative	1.47	Nonsignificant	—	0.00	Other	4	6
157	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.46	Nonsignificant	—	0.00	Other	0	0
158	EPI.ileal_bile_transport.detox_transcytosis	1.46	Nonsignificant	—	0.00	Other	0	1
159	EPI.lung_multiciliated.stress	1.46	Nonsignificant	—	0.00	Other	67	165
160	EC.liver_sinusoidal.hypoxia_metabolic	1.43	Nonsignificant	1.00	0.10	Other	183	107
161	MEL.stress_glucocorticoid	1.43	Nonsignificant	0.46	1.25	Other	11	34
162	EPI.hepatic_ductular_cholangiocyte.secretory_transport	1.43	Nonsignificant	—	0.89	Other	0	0
163	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	1.41	Nonsignificant	—	0.00	Other	0	0
164	EPI.pancreatic_islet.beta	1.41	Nonsignificant	0.28	1.27	Other	42	57
165	NEU.EXC_IT.neuromodulated	1.40	Nonsignificant	0.78	0.98	Other	176	116
166	EPI.colonocyte.distal_absorptive	1.38	Nonsignificant	—	2.20	Other	0	0
167	EPI.lung_club_secretory.ciliogenesis_primed	1.38	Nonsignificant	—	1.47	Other	0	0
168	EPI.tracheal_suprabasal.transitional_wound	1.36	Nonsignificant	—	0.43	Other	16	1
169	FIB.lung_alveolar.mito_secretory	1.33	Nonsignificant	—	0.00	Other	0	0
170	EC.heart_remodeling.remodeling_stalk	1.33	Nonsignificant	1.00	0.50	Other	33	111
171	MONO.CD14.remodeling	1.29	Nonsignificant	1.00	0.98	Other	2,373	295
172	EC.heart_remodeling.perivascular	1.28	Nonsignificant	1.00	0.35	Other	124	408
173	EPI.alveolar_type_2.stress_response	1.28	Nonsignificant	0.90	0.83	Other	675	1,562
174	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	1.25	Nonsignificant	0.82	1.08	Other	7	16
175	FIB.lung_alveolar.stress_interacting	1.21	Nonsignificant	—	0.00	Other	0	0
176	SMC.metabolic	1.18	Nonsignificant	0.65	0.91	Other	14	40
177	EPI.lung_club_secretory.ciliogenesis_axoneme	1.18	Nonsignificant	—	0.00	Other	0	0
178	HEP.acute_phase.stress_secretory	1.17	Nonsignificant	0.99	0.10	Other	26	3
179	EPI.skin_interfollicular_spinous.early_differentiation	1.14	Nonsignificant	0.26	1.51	Other	89	19
180	MONO.CD14.platelet_bound	1.11	Nonsignificant	1.00	0.83	Other	964	176
181	IPSC.endoderm_primed	1.11	Nonsignificant	1.00	0.12	Other	0	0
182	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.08	Nonsignificant	—	0.62	Other	0	0
183	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.08	Nonsignificant	—	0.00	Other	0	0
184	EPI.lung_club_secretory.canonical_surfactant	1.06	Nonsignificant	—	0.00	Other	74	104
185	EPI.alveolar_type_2.baseline_surfactant	1.04	Nonsignificant	0.90	0.46	Other	64	9
186	SMC.contractile	1.04	Nonsignificant	0.60	1.05	Other	80	588
187	NEU.EXC_NTNG1.nuclear_reg	1.03	Nonsignificant	—	0.67	Other	0	0
188	PERI.inflammatory	1.02	Nonsignificant	0.94	0.58	Other	40	77
189	MEL.secretory_quiescent	1.02	Nonsignificant	0.46	1.18	Other	19	13
190	EPI.ileal_enterocyte_absorptive.villus_tip	1.00	Nonsignificant	4.33e-05	2.60	Other	4	3
191	EC.liver_sinusoidal.prostanoid	0.99	Nonsignificant	—	0.00	Other	11	64
192	PERI.cardiac_skeletal	0.98	Nonsignificant	0.94	0.62	Other	313	630
193	EPI.tracheal_suprabasal.secretory_immune	0.98	Nonsignificant	—	0.00	Other	0	0
194	EPI.skin_interfollicular_spinous.baseline	0.98	Nonsignificant	0.99	0.82	Other	35	3
195	EPI.pancreatic_islet.alpha	0.97	Nonsignificant	—	0.43	Other	152	330
196	PERI.baseline	0.96	Nonsignificant	0.94	0.99	Other	39	66
197	EPI.skin_sweat_duct_keratinocyte.repair	0.96	Nonsignificant	—	0.00	Other	0	0
198	NEU.EXC_NTNG1.synaptic	0.90	Nonsignificant	—	0.00	Other	0	0
199	DC.pDC.immature_metabolic	0.90	Nonsignificant	0.27	1.41	Other	78	124
200	EPI.bile_duct_cholangiocyte.secretory_mucin	0.90	Nonsignificant	—	0.07	Other	7	12
201	NEU.INH_PVALB.chandelier	0.89	Nonsignificant	0.06	1.36	Other	19	16
202	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.88	Nonsignificant	0.96	0.36	Other	33	34
203	EPI.lung_club_secretory.inflammatory	0.86	Nonsignificant	—	0.00	Other	0	0
204	NEU.EXC_IT.structural	0.84	Nonsignificant	1.00	0.23	Other	171	41
205	MEL.mature_oxidative_traffic	0.84	Nonsignificant	0.62	0.91	Other	247	285
206	DC.pDC.baseline	0.83	Nonsignificant	0.90	0.92	Other	88	123
207	NEU.INH_PVALB.metabotropic	0.83	Nonsignificant	—	0.91	Other	0	0
208	HEP.acute_phase.hypoxia_lipid	0.80	Nonsignificant	—	0.00	Other	0	0
209	IPSC.canonical_pluripotent	0.80	Nonsignificant	1.00	0.00	Other	0	0
210	MEL.neurotrophic_migratory	0.80	Nonsignificant	—	0.00	Other	0	0
211	FIB.transitioning.motility_remodelling	0.79	Nonsignificant	—	0.17	Other	0	0
212	EPI.skin_interfollicular_spinous.stress_UPR	0.78	Nonsignificant	—	0.00	Other	0	0
213	EPI.colonic_enteroendocrine.progenitor	0.77	Nonsignificant	—	0.00	Other	0	0
214	FIB.transitioning.ISG_primed_interface	0.76	Nonsignificant	—	0.48	Other	17	80
215	EPI.skin_interfollicular_spinous.inflammatory	0.75	Nonsignificant	—	0.00	Other	0	0
216	EPI.skin_keratinocyte_proliferating.detox_repair	0.75	Nonsignificant	—	0.00	Other	0	0
217	EPI.ileal_goblet.baseline	0.71	Nonsignificant	0.81	1.11	Other	16	2
218	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.71	Nonsignificant	—	0.00	Other	2	0
219	PLAT.megakaryocytic	0.69	Nonsignificant	—	0.97	Other	0	0
220	EPI.skin_keratinocyte_basal.transit_amplifying	0.69	Nonsignificant	—	0.97	Other	0	0
221	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.68	Nonsignificant	—	0.24	Other	6	9
222	EPI.ileal_goblet.stress_metallothionein	0.68	Nonsignificant	—	0.28	Other	4	11
223	EPI.ileal_goblet.immature	0.68	Nonsignificant	—	0.00	Other	0	0
224	MAC.LAM.perivascular_angiocrine	0.68	Nonsignificant	—	2.12	Other	53	138
225	NEU.EXC_IT.adhesion	0.68	Nonsignificant	1.00	0.00	Other	252	108
226	OPC.premyelinating	0.68	Nonsignificant	3.12e-03	1.85	Other	185	12
227	EPI.esophageal_suprabasal.proliferative_exit	0.67	Nonsignificant	—	0.62	Other	0	0
228	EPI.skin_sweat_duct_keratinocyte.barrier	0.65	Nonsignificant	—	0.00	Other	0	0
229	THYMO.proliferative_S	0.64	Nonsignificant	0.07	1.25	Other	163	418
230	HEP.canalicular_transport.secretory_ERAD_UPR	0.63	Nonsignificant	0.06	1.53	Other	232	28
231	EPI.ileal_goblet.inflammatory_mucin	0.63	Nonsignificant	0.89	0.27	Other	6	9
232	EPI.skin_keratinocyte_basal.spinous_transition	0.62	Nonsignificant	—	0.00	Other	0	0
233	MEL.dedifferentiated_migratory	0.61	Nonsignificant	—	0.00	Other	0	0
234	EPI.esophageal_suprabasal.differentiating_keratin	0.60	Nonsignificant	0.03	1.92	Other	131	61
235	EPI.tracheal_basal.homeostatic_progenitor	0.59	Nonsignificant	0.39	1.41	Other	285	74
236	EPI.hepatic_ductular_cholangiocyte.polarity	0.58	Nonsignificant	—	0.17	Other	0	0
237	GRNLSA.EMT_insulin_signaling	0.54	Nonsignificant	0.42	1.32	Other	47	84
238	EPI.ileal_enterocyte_absorptive.brush_border	0.54	Nonsignificant	1.00	0.00	Other	580	1,717
239	EPI.skin_interfollicular_spinous.transition_basal	0.53	Nonsignificant	1.00	0.17	Other	100	127
240	EPI.colonocyte.ionocyte_BEST4	0.52	Nonsignificant	0.68	1.46	Other	103	188
241	EPI.tracheal_basal.activated_stress	0.50	Nonsignificant	0.75	0.71	Other	32	0
242	EPI.skin_interfollicular_spinous.upper_lipid	0.50	Nonsignificant	—	0.00	Other	6	6
243	HEP.periportal_metabolic.stress_chaperone	0.50	Nonsignificant	—	0.35	Other	66	128
244	EPI.ileal_enterocyte_crypt.secretory_precursor	0.50	Nonsignificant	—	0.00	Other	0	0
245	GRNLSA.cholesterol_mevalonate	0.48	Nonsignificant	0.42	1.28	Other	9	4
246	OPC.proliferative_immune_interact	0.48	Nonsignificant	0.74	1.01	Other	180	373
247	EPI.ectocervical_granular.secretory_apocrine	0.46	Nonsignificant	—	0.00	Other	0	0
248	EPI.salivary_duct_ion_transport.baseline	0.46	Nonsignificant	—	—	Other	0	0
249	EC.lymphatic.valve	0.46	Nonsignificant	—	2.18	Other	0	0
250	EPI.esophageal_suprabasal.proliferative_S	0.45	Nonsignificant	—	0.00	Other	26	41
251	DC.pDC.poised_migratory	0.44	Nonsignificant	0.98	0.29	Other	54	95
252	THYMO.DN_preTCR	0.44	Nonsignificant	0.23	1.15	Other	41	71
253	ADIPO.hypoxia_remodelling	0.44	Nonsignificant	—	1.05	Other	29	105
254	NEU.EXC_SYT2.synaptic	0.44	Nonsignificant	—	0.00	Other	0	0
255	FIB.transitioning.secretory_procollagen	0.43	Nonsignificant	—	0.37	Other	0	0
256	EPI.skin_hair_follicle_companion.activated_migratory	0.43	Nonsignificant	—	0.97	Other	0	0
257	PLAT.adhesion	0.42	Nonsignificant	—	0.00	Other	0	0
258	EPI.esophageal_suprabasal.proliferative_G2M	0.42	Nonsignificant	—	0.00	Other	0	0
259	THYMO.proliferative_G2M	0.41	Nonsignificant	—	1.21	Other	164	413
260	EPI.salivary_mucous_acinar.baseline	0.41	Nonsignificant	—	—	Other	394	683
261	EPI.skin_keratinocyte_basal.basement_anchoring	0.40	Nonsignificant	—	0.00	Other	0	0
262	GRNLSA.chemokine_mechanosensory	0.40	Nonsignificant	0.75	0.97	Other	1	0
263	T.CD4_Trm.baseline	0.37	Nonsignificant	0.87	1.15	Other	31	21
264	HEP.periportal_metabolic.urea_onecarbon_secretory	0.36	Nonsignificant	7.28e-03	1.39	Other	1,332	3,053
265	HPC.MPP_activated	0.36	Nonsignificant	—	0.00	Other	0	0
266	GRNLSA.lipid_hypoxia	0.35	Nonsignificant	0.75	0.96	Other	28	0
267	GRNLSA.p53_damage	0.34	Nonsignificant	—	0.41	Other	13	10
268	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.32	Nonsignificant	—	1.15	Other	0	0
269	EPI.gastric_foveolar.baseline	0.32	Nonsignificant	—	0.00	Other	0	0
270	HEP.canalicular_transport.ductular_like_transition	0.30	Nonsignificant	0.65	1.17	Other	400	87
271	MESO.antiviral	0.30	Nonsignificant	—	0.22	Other	3	8
272	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.30	Nonsignificant	—	0.00	Other	0	0
273	EC.lymphatic.activated	0.29	Nonsignificant	0.61	1.27	Other	47	73
274	MONO.CD14.cord_tolerance	0.29	Nonsignificant	1.00	0.44	Other	864	753
275	MONO.CD16.platelet_bound	0.28	Nonsignificant	0.54	1.27	Other	372	508
276	NEU.EXC_CT.projector	0.28	Nonsignificant	0.17	1.40	Other	87	26
277	EPI.skin_hair_follicle_bulge.anagen_growth	0.27	Nonsignificant	—	1.80	Other	0	0
278	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.25	Nonsignificant	—	0.00	Other	0	0
279	EC.lymphatic.tip_migratory	0.25	Nonsignificant	0.61	1.18	Other	23	37
280	THYMO.SP_CD8_transitional	0.25	Nonsignificant	0.85	1.11	Other	32	75
281	T.CD4_Tfh.canonical_GC_helper	0.25	Nonsignificant	0.35	1.30	Other	1	2
282	HPC.GMP_granulocytic	0.24	Nonsignificant	—	0.00	Other	3	3
283	EPI.hepatic_ductular_cholangiocyte.stress	0.24	Nonsignificant	—	0.00	Other	0	0
284	DC.cDC2.lipid_metabolic	0.23	Nonsignificant	—	2.15	Other	0	0
285	T.CD4_Trm.helper_like	0.23	Nonsignificant	0.87	1.14	Other	84	147
286	EPI.colonic_tuft.activated	0.23	Nonsignificant	—	0.42	Other	0	0
287	OPC.homeostatic	0.22	Nonsignificant	1.00	0.00	Other	394	160
288	EPI.esophageal_suprabasal.basal_transitional	0.22	Nonsignificant	1.00	0.00	Other	44	67
289	EPI.alveolar_type_1.activated	0.22	Nonsignificant	—	0.13	Other	0	0
290	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.21	Nonsignificant	—	0.00	Other	0	0
291	EC.lymphatic.baseline	0.21	Nonsignificant	0.71	0.98	Other	38	72
292	EPI.alveolar_type_1.baseline	0.21	Nonsignificant	0.58	0.96	Other	8	0
293	MONO.CD14.inflammatory	0.21	Nonsignificant	1.00	0.49	Other	92	134
294	T.CD4_Treg.tissue_effector	0.20	Nonsignificant	0.19	1.37	Other	16	13
295	DC.cDC1.cross_presenting	0.20	Nonsignificant	—	1.01	Other	0	0
296	FIB.suburothelial.urothelial_interface	0.19	Nonsignificant	2.63e-03	2.01	Other	9	8
297	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.19	Nonsignificant	—	0.09	Other	29	88
298	EPI.skin_hair_follicle_bulge.quiescent	0.19	Nonsignificant	0.84	0.53	Other	56	69
299	NEU.EXC_CT.Ca2_signaling	0.19	Nonsignificant	—	0.00	Other	68	17
300	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.18	Nonsignificant	—	0.00	Other	0	0
301	NEU.EXC_CT.remodeling	0.18	Nonsignificant	—	0.00	Other	23	1
302	HEP.periportal_metabolic.acute_phase_barrier	0.18	Nonsignificant	0.93	0.85	Other	533	138
303	EPI.salivary_duct_excretory.baseline	0.18	Nonsignificant	0.28	1.49	Other	23	57
304	FIB.reticular.immune_interface	0.18	Nonsignificant	—	0.37	Other	1	6
305	MESO.secretory_structural	0.17	Nonsignificant	—	0.23	Other	0	0
306	T.CD4_transitional.tissue_enagement	0.17	Nonsignificant	0.06	1.33	Other	5	11
307	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.17	Nonsignificant	—	0.00	Other	0	0
308	HEP.canalicular_transport.inflammatory	0.17	Nonsignificant	1.00	0.80	Other	1,335	194
309	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.17	Nonsignificant	—	0.00	Other	10	20
310	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.17	Nonsignificant	—	0.00	Other	39	82
311	EPI.colonic_tuft.homeostatic	0.16	Nonsignificant	—	0.00	Other	0	0
312	HEP.periportal_metabolic.xenobiotic_detox	0.16	Nonsignificant	0.93	0.81	Other	1,440	139
313	GRNLSA.secretory_remodeling	0.16	Nonsignificant	0.98	0.49	Other	90	25
314	FIB.reticular.stress_metallothionein	0.16	Nonsignificant	—	0.14	Other	3	32
315	SCHWN.axon_contact_cardiac	0.16	Nonsignificant	0.35	1.19	Other	18	63
316	GRANU.MAST.resting_granule	0.15	Nonsignificant	—	1.05	Other	0	0
317	T.CD4_Tfh.suppression_exhaustion	0.15	Nonsignificant	0.35	1.25	Other	0	2
318	MAC.alveolar.inflammatory	0.15	Nonsignificant	0.37	1.21	Other	208	312
319	HPC.GMP_inflammatory	0.15	Nonsignificant	1.00	0.18	Other	20	10
320	MAC.resident_iron.stress_tolerogenic	0.14	Nonsignificant	—	1.05	Other	0	0
321	HEP.periportal_metabolic.canonical_urea_cycle	0.14	Nonsignificant	0.93	1.03	Other	1,464	269
322	EPI.salivary_myoepithelial.contractile_repair	0.14	Nonsignificant	—	0.85	Other	3	9
323	EPI.renal_distal_tubule.ciliated_remodelling	0.14	Nonsignificant	—	0.00	Other	0	0
324	FIB.barrier_purinergic.lipid_secretory	0.14	Nonsignificant	—	0.48	Other	0	0
325	HEP.canalicular_transport.pericentral_like_hypoxia	0.14	Nonsignificant	1.00	0.79	Other	326	8
326	EPI.skin_sebaceous_duct_luminal.detox_repair	0.14	Nonsignificant	0.03	2.07	Other	137	94
327	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.14	Nonsignificant	—	0.37	Other	0	0
328	DC.cDC1.activated	0.14	Nonsignificant	—	0.36	Other	0	0
329	FIB.transitioning.matrix_stress	0.14	Nonsignificant	—	0.00	Other	47	138
330	FIB.interstitial.mesenchymal_regulator	0.13	Nonsignificant	0.30	1.15	Other	4	4
331	EPI.colonocyte.secretory_boost	0.13	Nonsignificant	0.78	1.11	Other	98	91
332	MESO.baseline	0.13	Nonsignificant	0.62	0.93	Other	0	6
333	FIB.perivascular_interface.vascular_BM_remodelling	0.13	Nonsignificant	—	0.51	Other	0	0
334	HEP.periportal_metabolic.apolipoprotein_secretory	0.13	Nonsignificant	0.93	0.76	Other	43	110
335	EPI.salivary_myoepithelial.baseline	0.13	Nonsignificant	0.55	1.35	Other	42	141
336	HEP.periportal_metabolic.stress_checkpoint	0.13	Nonsignificant	0.93	0.90	Other	234	786
337	HEP.pericentral_lipoprotein.ApoB_coagulation	0.13	Nonsignificant	—	0.67	Other	0	0
338	EPI.skin_sebaceous_duct_luminal.immune_interface	0.12	Nonsignificant	—	0.09	Other	0	0
339	ILC2.quiescent	0.12	Nonsignificant	—	0.80	Other	0	0
340	T.CD4_Trm.activated	0.12	Nonsignificant	0.90	1.03	Other	32	26
341	T.CD4_Treg.Tr1_like	0.11	Nonsignificant	—	0.00	Other	8	8
342	HEP.pericentral_lipoprotein.UPR_redox	0.11	Nonsignificant	—	0.00	Other	0	0
343	FIB.reticular.stromal_niche	0.11	Nonsignificant	0.51	1.02	Other	0	0
344	EPI.esophageal_basal.activated_progenitor	0.11	Nonsignificant	0.15	1.64	Other	1	0
345	MESO.activated_migratory	0.11	Nonsignificant	—	0.10	Other	0	0
346	FIB.perivascular_interface.vasomotor_tone	0.11	Nonsignificant	—	0.17	Other	0	0
347	MAC.LAM.lipid_opsonization	0.11	Nonsignificant	0.80	1.18	Other	45	14
348	SCHWN.translation_boost	0.10	Nonsignificant	—	0.00	Other	8	1
349	EC.lymphatic.scavenger	0.10	Nonsignificant	1.00	0.03	Other	203	257
350	EPI.salivary_myoepithelial.activated	0.10	Nonsignificant	0.98	0.69	Other	85	281
351	EPI.salivary_duct_excretory.stress	0.10	Nonsignificant	0.92	0.39	Other	33	68
352	GRNLSA.stress_metabolic	0.10	Nonsignificant	—	0.00	Other	1	2
353	ASTRO.synaptic_interaction	0.10	Nonsignificant	0.67	1.17	Other	76	334
354	T.CD8_Trm.muscosal_Tc17	0.10	Nonsignificant	0.07	1.21	Other	19	38
355	MAC.alveolar.capillary_interacting	0.10	Nonsignificant	0.94	1.05	Other	113	181
356	HEP.canalicular_transport.injury_stress	0.09	Nonsignificant	1.00	0.31	Other	289	24
357	FIB.reticular.ECM_builder	0.09	Nonsignificant	—	0.00	Other	0	0
358	EPI.esophageal_basal.junctional_barrier	0.09	Nonsignificant	—	0.00	Other	0	0
359	EPI.colonocyte.proximal_transport	0.09	Nonsignificant	0.78	1.08	Other	24	12
360	T.CD4_transitional.APC_interacting	0.09	Nonsignificant	0.08	1.31	Other	10	14
361	MAC.resident_iron.redox_metabolic	0.09	Nonsignificant	0.54	1.30	Other	4	4
362	T.CD4_Trm.metal_stress	0.09	Nonsignificant	0.90	1.09	Other	34	58
363	EPI.salivary_myoepithelial.junctional_transport	0.08	Nonsignificant	0.98	0.16	Other	66	121
364	FIB.suburothelial.contractile_myofibroblast	0.08	Nonsignificant	—	0.02	Other	9	0
365	MAC.alveolar.lipid_autophagy	0.08	Nonsignificant	—	0.26	Other	35	44
366	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.08	Nonsignificant	—	0.00	Other	5	3
367	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.08	Nonsignificant	0.97	0.08	Other	2	9
368	DC.cDC1.homeostatic_inhibitory	0.08	Nonsignificant	—	0.00	Other	0	0
369	T.CD4_Trm.cytotoxic_effector	0.08	Nonsignificant	1.00	0.92	Other	118	77
370	FIB.suburothelial.inflammatory_prostanoid	0.08	Nonsignificant	—	0.00	Other	0	0
371	MONO.CD14.repair_M2_like	0.08	Nonsignificant	1.00	0.28	Other	550	1,495
372	EPI.skin_keratinocyte_progenitor.activated_stress	0.08	Nonsignificant	—	0.00	Other	0	0
373	NEU.INH_PVALB.serotonergic	0.07	Nonsignificant	—	0.00	Other	0	0
374	MONO.CD16.baseline	0.07	Nonsignificant	0.57	1.11	Other	50	1
375	HPC.CLP_B_primed	0.07	Nonsignificant	—	0.00	Other	0	0
376	EPI.salivary_serous_acinar.seromucous_like	0.07	Nonsignificant	—	2.17	Other	0	0
377	DC.cDC2.pro_inflammatory	0.07	Nonsignificant	0.25	1.28	Other	3	5
378	HEP.periportal_metabolic.inflammatory_activated	0.07	Nonsignificant	0.93	0.80	Other	712	1,610
379	DC.cDC1.proliferative	0.07	Nonsignificant	—	0.00	Other	0	0
380	ASPC.proliferative	0.07	Nonsignificant	0.45	1.24	Other	33	85
381	EPI.salivary_intercalated_defense.basal_EMT	0.07	Nonsignificant	—	1.00	Other	0	0
382	DC.mig.baseline	0.07	Nonsignificant	—	0.00	Other	1	0
383	ASPC.mesothelial_like	0.06	Nonsignificant	0.33	1.35	Other	143	486
384	HEP.canalicular_transport.baseline	0.06	Nonsignificant	1.00	0.19	Other	199	477
385	GRANU.MAST.activated_repair	0.06	Nonsignificant	—	0.00	Other	0	1
386	ASPC.adipocyte_capillary_interface	0.06	Nonsignificant	0.49	1.14	Other	21	54
387	FIB.perivascular_interface.lipid_shuttle	0.06	Nonsignificant	—	0.00	Other	51	170
388	FIB.suburothelial.homeostasis_matrix	0.06	Nonsignificant	1.00	0.00	Other	258	921
389	FIB.hepatic_stellate_cell.fibrogenic	0.05	Nonsignificant	—	0.73	Other	0	0
390	SCHWN.reactive_inflammatory	0.05	Nonsignificant	—	0.00	Other	0	0
391	ASPC.niche_keeping_progenitor	0.05	Nonsignificant	0.45	1.09	Other	52	219
392	EPI.tracheal_submucosal_gland.acinar_serous	0.05	Nonsignificant	—	0.42	Other	0	0
393	T.CD4_Treg.APC_interactive	0.05	Nonsignificant	1.00	0.79	Other	118	28
394	T.MAIT.migratory	0.05	Nonsignificant	0.46	1.46	Other	10	1
395	T.CD4_naive.mature_mitoprot	0.04	Nonsignificant	0.78	1.07	Other	212	476
396	MAC.alveolar.scavenging_endocytic	0.04	Nonsignificant	—	0.31	Other	140	283
397	FIB.hepatic_stellate_cell.inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
398	FIB.interstitial.remodeling	0.04	Nonsignificant	0.77	1.05	Other	31	9
399	ASPC.secretory	0.04	Nonsignificant	0.45	1.06	Other	76	5
400	T.MAIT.early_activation	0.04	Nonsignificant	0.50	1.31	Other	57	4
401	T.CD4_Tfh.effector_migratory	0.04	Nonsignificant	1.00	0.74	Other	122	57
402	T.CD4_transitional.primed_helper_effector	0.04	Nonsignificant	0.68	1.08	Other	19	43
403	MAC.resident_iron.heme_catabolism	0.04	Nonsignificant	0.87	0.88	Other	30	51
404	EPI.pancreatic_islet.delta	0.04	Nonsignificant	—	0.00	Other	0	0
405	EPI.colonocyte.junction_remodeling	0.04	Nonsignificant	1.00	0.48	Other	218	305
406	MAC.MDM.inflammatory_phagocytic	0.04	Nonsignificant	0.56	1.17	Other	199	52
407	THYMO.SP_CD4_naive	0.04	Nonsignificant	1.00	0.69	Other	65	75
408	NEU.INH_PVALB.nuclear_reg	0.04	Nonsignificant	0.95	0.41	Other	25	12
409	EPI.colonocyte.crypt_progenitor	0.04	Nonsignificant	1.00	0.25	Other	115	265
410	NK.adaptive_classII_inhibitory	0.04	Nonsignificant	0.35	1.17	Other	880	154
411	MAC.proliferating.DNA_replication	0.03	Nonsignificant	0.70	0.81	Other	3	6
412	NEU.EXC_CT.Ca2_sensor	0.03	Nonsignificant	—	0.00	Other	0	0
413	PC.IgG_systemic.secretory	0.03	Nonsignificant	0.41	1.16	Other	0	0
414	GRANU.MAST.activated_acute	0.03	Nonsignificant	—	0.00	Other	0	0
415	FIB.skin_tenogenic.baseline	0.03	Nonsignificant	—	0.00	Other	0	2
416	T.CD4_Th2.precursor	0.03	Nonsignificant	—	0.48	Other	0	0
417	MAC.proliferating.stress	0.03	Nonsignificant	—	0.00	Other	87	136
418	T.CD4_naive.activated_stress	0.03	Nonsignificant	0.78	1.49	Other	339	429
419	EPI.skin_follicular_keratinizing.transit_amplifying	0.03	Nonsignificant	—	0.31	Other	21	49
420	FIB.skin_sheath.ECM_immune	0.03	Nonsignificant	—	0.59	Other	0	0
421	MONO.CD16.hepatic_mac_like	0.03	Nonsignificant	0.65	1.06	Other	803	117
422	T.MAIT.cytotoxic	0.03	Nonsignificant	0.82	1.09	Other	52	15
423	MAC.LAM.anti_inflammatory	0.03	Nonsignificant	0.80	0.97	Other	86	132
424	FIB.skin_sheath.neuro_vascular_interface	0.03	Nonsignificant	—	0.00	Other	0	0
425	T.MAIT.quiescent	0.03	Nonsignificant	0.82	0.98	Other	100	5
426	GRNLSA.proliferative_migratory	0.03	Nonsignificant	0.75	0.93	Other	248	292
427	T.CD4_naive.homeostatic	0.03	Nonsignificant	0.78	1.10	Other	215	108
428	EPI.salivary_intercalated_defense.inflammatory	0.03	Nonsignificant	0.61	0.99	Other	152	360
429	EPI.salivary_serous_acinar.quiescent	0.03	Nonsignificant	0.21	1.12	Other	178	493
430	MAC.resident_repair.chemokine_angiocrine	0.03	Nonsignificant	0.56	1.22	Other	87	138
431	FIB.hepatic_stellate_cell.contractile	0.03	Nonsignificant	—	0.00	Other	0	0
432	EPI.tracheal_submucosal_gland.ductal_luminal	0.03	Nonsignificant	—	0.00	Other	0	0
433	DC.cDC1.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
434	MAC.LAM.antimicrobial	0.02	Nonsignificant	0.80	0.92	Other	389	93
435	THYMO.DP_early	0.02	Nonsignificant	1.00	0.67	Other	326	313
436	T.CD4_naive.Treg_like	0.02	Nonsignificant	0.78	1.12	Other	121	72
437	T.CD4_naive.mature	0.02	Nonsignificant	0.78	1.06	Other	211	100
438	T.gamma_delta.early_effector	0.02	Nonsignificant	0.18	1.28	Other	89	0
439	T.MAIT.MAPK_brake	0.02	Nonsignificant	0.82	0.87	Other	44	66
440	T.CD4_naive.survival_neddylation	0.02	Nonsignificant	0.78	1.00	Other	26	38
441	NEU.INH_PVALB.fastspike	0.02	Nonsignificant	—	0.00	Other	24	22
442	T.CD4_Tfh.precursor_migratory	0.02	Nonsignificant	1.00	0.32	Other	72	27
443	ASPC.preadipocyte_lipid_primed	0.02	Nonsignificant	0.98	0.99	Other	331	129
444	T.CD4_naive.neddylation_mitoprot	0.02	Nonsignificant	0.78	1.12	Other	93	56
445	MAC.LAM.lipid_phagocytosis	0.02	Nonsignificant	0.80	0.96	Other	369	328
446	EPI.skin_follicular_keratinizing.upper_infundibulum	0.02	Nonsignificant	—	0.00	Other	8	2
447	MAC.resident_iron.APC_iron_sensing	0.02	Nonsignificant	0.87	0.78	Other	211	114
448	NK.cytokine_repair_primed	0.02	Nonsignificant	0.29	1.25	Other	266	11
449	FIB.skin_sheath.stress_chaperone	0.02	Nonsignificant	—	0.00	Other	0	0
450	PC.IgA_muocsal.plasmablast	0.02	Nonsignificant	0.27	1.17	Other	5	4
451	T.CD4_Tcm.Th2_like	0.02	Nonsignificant	0.94	1.17	Other	23	55
452	MAC.MDM.APC_dendritic	0.02	Nonsignificant	0.90	0.99	Other	48	15
453	MUSC.activated_migratory	0.02	Nonsignificant	0.45	1.39	Other	6	7
454	MAC.LAM.inflammatory_APC	0.02	Nonsignificant	0.99	0.65	Other	872	165
455	MAC.kupffer.tolerogenic	0.02	Nonsignificant	—	0.80	Other	45	49
456	T.CD8_Tem.early_helper_like	0.02	Nonsignificant	0.07	1.20	Other	445	755
457	T.CD4_naive.proteostasis_mitoprot	0.02	Nonsignificant	0.78	1.08	Other	15	37
458	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.02	Nonsignificant	0.61	0.95	Other	11	22
459	MONO.CD16.inflammatory	0.02	Nonsignificant	0.88	0.96	Other	1,640	168
460	T.CD4_naive.survival_mitoprot	0.02	Nonsignificant	0.81	0.84	Other	13	7
461	T.CD4_naive.resist_bystander	0.02	Nonsignificant	0.81	0.83	Other	40	25
462	T.MAIT.vesicle	0.02	Nonsignificant	0.85	0.62	Other	37	65
463	EPI.skin_follicular_keratinizing.root_infundibulum	0.02	Nonsignificant	—	0.00	Other	0	0
464	T.CD4_naive.survival	0.02	Nonsignificant	0.81	0.85	Other	12	17
465	NK.cytokine_lung_immediate_early	0.02	Nonsignificant	0.85	1.14	Other	424	274
466	T.CD4_Tcm.imprinted_splicing	0.02	Nonsignificant	0.67	1.21	Other	6	17
467	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.56	1.01	Other	28	6
468	T.CD4_naive.proteostasis	0.02	Nonsignificant	0.81	0.90	Other	14	9
469	T.CD8_transitional.Trm_primed	0.02	Nonsignificant	0.32	1.15	Other	108	15
470	PC.IgG_systemic.interacting	0.02	Nonsignificant	0.41	1.20	Other	0	0
471	FIB.skin_papillary.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
472	T.CD4_transitional.baseline	0.02	Nonsignificant	0.93	0.83	Other	59	97
473	T.MAIT.stress	0.02	Nonsignificant	—	0.00	Other	0	0
474	T.CD4_naive.neddylation	0.02	Nonsignificant	0.78	1.00	Other	104	222
475	T.CD8_transitional.APC_like	0.02	Nonsignificant	0.32	1.09	Other	205	62
476	T.CD4_Trm.stress_adaptive	0.02	Nonsignificant	1.00	0.73	Other	8	22
477	MAC.kupffer.stress	0.02	Nonsignificant	0.48	1.08	Other	9	3
478	T.CD4_cytotoxic.baseline	0.02	Nonsignificant	0.50	1.30	Other	0	0
479	T.CD4_Tcm.secretory	0.01	Nonsignificant	0.35	1.30	Other	20	11
480	DC.cDC2.proliferative	0.01	Nonsignificant	—	0.36	Other	39	71
481	T.CD4_Tem.cytotoxic_effector	0.01	Nonsignificant	0.03	1.22	Other	225	398
482	ASPC.inflammatory	0.01	Nonsignificant	0.98	0.93	Other	21	61
483	OLG.regulatory	0.01	Nonsignificant	3.37e-03	1.21	Other	353	73
484	NEU.INH_PVALB.neuromodulatory	0.01	Nonsignificant	—	0.00	Other	0	0
485	FIB.barrier_purinergic.stress_GF_binding	0.01	Nonsignificant	—	0.00	Other	0	0
486	FIB.tracheal_subepithelial.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
487	T.CD4_Treg.central_naive_like	0.01	Nonsignificant	1.00	0.36	Other	333	45
488	THYMO.SP_CD8_naive_stress	0.01	Nonsignificant	1.00	0.61	Other	1	1
489	T.CD4_naive.purinergic	0.01	Nonsignificant	0.81	0.86	Other	49	1
490	T.CD8_Tem.signaling_turnover	0.01	Nonsignificant	0.80	1.10	Other	425	683
491	NK.immature_bridge	0.01	Nonsignificant	0.85	1.10	Other	117	122
492	T.CD8_Tem.baseline	0.01	Nonsignificant	0.80	1.03	Other	458	356
493	FIB.interstitial.immune_interact	0.01	Nonsignificant	0.95	0.93	Other	12	1
494	ASTRO.hypoxia_angiogenic	0.01	Nonsignificant	1.00	0.98	Other	5	18
495	DC.cDC2.antiviral	0.01	Nonsignificant	1.00	0.90	Other	100	37
496	ASTRO.A2_reactive	0.01	Nonsignificant	1.00	0.89	Other	10	37
497	MAC.MDM.LAM_like	0.01	Nonsignificant	0.90	0.90	Other	12	14
498	T.CD4_Tem.transitional_CM	0.01	Nonsignificant	0.56	1.00	Other	31	20
499	OLG.reactive_repair	0.01	Nonsignificant	0.86	1.07	Other	385	385
500	DC.cDC2.tolerogenic_regulatory	0.01	Nonsignificant	1.00	0.87	Other	44	4
501	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	0.55	1.08	Other	314	587
502	PC.IgG_systemic.stress	0.01	Nonsignificant	—	0.49	Other	1	5
503	NK.adaptive_HLAE_tuned	0.01	Nonsignificant	0.29	1.15	Other	1,124	189
504	B.age_associated.migratory	0.01	Nonsignificant	0.26	1.28	Other	2	2
505	ASPC.baseline	0.01	Nonsignificant	0.98	0.94	Other	363	170
506	MESO.activated_stress	0.01	Nonsignificant	—	0.00	Other	0	0
507	T.CD4_transitional.primed_cytotoxic	0.01	Nonsignificant	0.93	0.78	Other	28	30
508	T.CD4_cytotoxic.NK_adapted	0.01	Nonsignificant	0.08	1.43	Other	82	33
509	OLG.stress	0.01	Nonsignificant	0.86	1.03	Other	232	8
510	FIB.interstitial.stress_secretory	9.96e-03	Nonsignificant	0.78	1.08	Other	92	56
511	T.CD4_Tcm.Tfh_like	9.94e-03	Nonsignificant	0.82	1.13	Other	102	214
512	FIB.adventitial.adhesion_lipid	9.86e-03	Nonsignificant	0.68	1.20	Other	58	209
513	FIB.barrier_secretory.homeostasis	9.66e-03	Nonsignificant	—	0.00	Other	0	0
514	MUSC.baseline	9.65e-03	Nonsignificant	0.71	0.86	Other	0	0
515	T.CD8_Tem.stress_adapted	9.64e-03	Nonsignificant	0.80	0.97	Other	607	520
516	THYMO.SP_CD8_naive	9.20e-03	Nonsignificant	1.00	0.46	Other	297	177
517	T.gamma_delta.cytotoxic_effector	9.11e-03	Nonsignificant	0.89	0.85	Other	349	109
518	T.CD4_Th2.tissue_adapted	8.97e-03	Nonsignificant	—	0.00	Other	0	0
519	MUSC.early_activation	8.93e-03	Nonsignificant	0.51	1.26	Other	4	32
520	DC.cDC2.monocyte_like	8.80e-03	Nonsignificant	1.00	0.98	Other	1,285	791
521	T.CD8_Trm.inflammatory	8.39e-03	Nonsignificant	0.93	1.00	Other	124	176
522	FIB.adventitial.mechano_chemo_sensing	8.35e-03	Nonsignificant	0.83	1.10	Other	135	524
523	EPI.colonocyte.goblet_interface	8.34e-03	Nonsignificant	—	0.00	Other	11	21
524	T.CD8_Tem.TEMRA	8.12e-03	Nonsignificant	0.80	0.97	Other	920	1,088
525	MAC.resident_iron.heme_recycling	8.09e-03	Nonsignificant	—	0.00	Other	30	37
526	MAC.alveolar.stress_metabolic	8.01e-03	Nonsignificant	1.00	0.54	Other	116	148
527	MUSC.quiescent_reservoir	7.96e-03	Nonsignificant	0.71	0.87	Other	2	8
528	ASPC.activated	7.82e-03	Nonsignificant	0.98	0.86	Other	164	162
529	T.CD4_Tcm.stress	7.80e-03	Nonsignificant	0.94	1.03	Other	5	11
530	T.gamma_delta.central_memory	7.75e-03	Nonsignificant	0.89	0.74	Other	460	919
531	ASTRO.homeostatic	7.20e-03	Nonsignificant	1.00	0.89	Other	200	431
532	ASTRO.immature_lipid	7.19e-03	Nonsignificant	1.00	1.11	Other	23	113
533	MAC.resident_repair.lipid_phagocytic	7.14e-03	Nonsignificant	0.65	1.08	Other	228	604
534	T.CD4_cytotoxic.terminal_effector	7.13e-03	Nonsignificant	0.86	0.85	Other	286	21
535	NK.adaptive_axis_baseline	7.02e-03	Nonsignificant	0.90	0.99	Other	1,008	153
536	MAC.MDM.complement_resolving	6.78e-03	Nonsignificant	0.97	0.68	Other	440	860
537	T.CD4_Trm.central_like	6.72e-03	Nonsignificant	1.00	0.40	Other	38	31
538	T.CD4_Th17.cytotoxic	6.57e-03	Nonsignificant	0.61	1.13	Other	332	123
539	T.CD8_transitional.effector_primed	6.33e-03	Nonsignificant	0.94	0.91	Other	435	151
540	T.CD4_Tcm.effector_like	6.22e-03	Nonsignificant	0.35	1.21	Other	293	533
541	T.CD4_Tcm.tissue_homing	6.18e-03	Nonsignificant	0.94	1.07	Other	78	46
542	T.CD4_naive.gut_prone	6.04e-03	Nonsignificant	0.95	0.45	Other	35	70
543	T.CD8_transitional.early	5.91e-03	Nonsignificant	0.94	0.88	Other	327	55
544	THYMO.DP_early_stress	5.83e-03	Nonsignificant	—	0.00	Other	0	0
545	B.age_associated.activated	5.83e-03	Nonsignificant	—	0.60	Other	18	22
546	T.CD4_cytotoxic.activated	5.36e-03	Nonsignificant	0.86	0.92	Other	3	1
547	T.CD4_Tcm.crosstalk_myeloid	4.88e-03	Nonsignificant	0.94	0.91	Other	5	4
548	MAC.resident_repair.stress_iron	4.85e-03	Nonsignificant	0.65	1.09	Other	48	97
549	FIB.skin_neurosecretory.baseline	4.84e-03	Nonsignificant	—	0.00	Other	0	0
550	PC.IgA_muocsal.activated	4.83e-03	Nonsignificant	0.27	1.08	Other	17	8
551	OLG.regulatory_activated	4.71e-03	Nonsignificant	1.00	0.82	Other	196	614
552	T.CD4_Tcm.migratory_cilium	4.48e-03	Nonsignificant	0.94	0.97	Other	5	10
553	T.CD4_cytotoxic.precursor	4.32e-03	Nonsignificant	0.86	0.68	Other	156	67
554	MONO.CD16.patrolling	4.29e-03	Nonsignificant	1.00	0.61	Other	797	216
555	ASPC.remodeling	4.09e-03	Nonsignificant	0.98	0.76	Other	106	354
556	T.CD4_Tcm.baseline	4.08e-03	Nonsignificant	0.94	0.89	Other	61	31
557	MONO.CD14.APC_like	4.00e-03	Nonsignificant	1.00	0.06	Other	1,686	2,493
558	T.CD8_naive.vesicle_secretory	3.92e-03	Nonsignificant	0.49	1.33	Other	42	0
559	PC.IgA_muocsal.baseline	3.88e-03	Nonsignificant	0.75	0.95	Other	3	5
560	NK.adaptive_biosynthetic_primed	3.78e-03	Nonsignificant	0.90	0.92	Other	244	405
561	MAC.resident_repair.ECM_stromal_crosstalk	3.74e-03	Nonsignificant	0.76	0.82	Other	95	158
562	B.memory.activated	3.67e-03	Nonsignificant	0.36	1.08	Other	105	29
563	NK.adaptive_adipose_stress	3.51e-03	Nonsignificant	0.90	0.93	Other	374	39
564	FIB.adventitial.PI16_matrix	3.49e-03	Nonsignificant	0.91	1.02	Other	70	90
565	PC.IgA_muocsal.migratory	3.32e-03	Nonsignificant	0.75	0.98	Other	4	1
566	CM.contractile_oxphos	3.21e-03	Nonsignificant	0.60	1.10	Other	6	19
567	FIB.adventitial.complement_angiocrine	3.11e-03	Nonsignificant	0.91	0.94	Other	153	684
568	DC.cDC2.migratory	2.85e-03	Nonsignificant	1.00	0.63	Other	185	39
569	T.CD4_Th17.baseline	2.83e-03	Nonsignificant	0.74	0.98	Other	51	5
570	T.CD8_Trm.dendritic_recruiter	2.73e-03	Nonsignificant	0.93	0.90	Other	47	85
571	MAC.kupffer.monocyte_like	2.70e-03	Nonsignificant	—	0.16	Other	0	0
572	MG.phagocytic_APC	2.67e-03	Nonsignificant	0.66	1.04	Other	25	8
573	T.CD8_Tcm.helper_like	2.66e-03	Nonsignificant	0.77	1.12	Other	81	159
574	T.CD4_Tcm.RNA_control	2.61e-03	Nonsignificant	0.95	0.80	Other	96	4
575	ASTRO.neuromodulatory	2.55e-03	Nonsignificant	1.00	1.01	Other	34	172
576	T.CD4_Tcm.regulatory_poised	2.50e-03	Nonsignificant	0.94	0.85	Other	2	3
577	T.CD4_Tcm.retro_ZNF117	2.46e-03	Nonsignificant	0.94	0.92	Other	5	9
578	T.CD8_Trm.cytotoxic	2.41e-03	Nonsignificant	0.93	0.96	Other	165	85
579	B.memory.preactivated	2.39e-03	Nonsignificant	0.36	1.09	Other	173	174
580	ILC2.migratory	2.32e-03	Nonsignificant	—	0.23	Other	0	0
581	T.CD8_Tcm.effector_bias	2.20e-03	Nonsignificant	0.90	1.09	Other	199	329
582	MG.baseline	2.18e-03	Nonsignificant	0.66	1.03	Other	16	5
583	OLG.vesicle_trafficking	2.14e-03	Nonsignificant	1.00	0.73	Other	124	10
584	B.naive.restrained	2.10e-03	Nonsignificant	0.84	1.01	Other	183	353
585	B.naive.activated	2.01e-03	Nonsignificant	0.84	1.03	Other	77	127
586	NK.cytokine_tissue_resident	1.99e-03	Nonsignificant	0.90	0.86	Other	74	82
587	NK.cytokine_vascular_patrolling	1.98e-03	Nonsignificant	0.90	1.03	Other	863	94
588	T.CD4_Th17.migratory	1.96e-03	Nonsignificant	0.74	0.93	Other	13	23
589	NK.cytokine_axis_baseline	1.95e-03	Nonsignificant	0.94	0.93	Other	1,172	116
590	NK.cytokine_biosynthetic_primed	1.93e-03	Nonsignificant	0.90	1.08	Other	360	21
591	MAC.resident_repair.antigen_presenting	1.89e-03	Nonsignificant	0.65	1.00	Other	244	113
592	ASTRO.stress_mito	1.81e-03	Nonsignificant	1.00	0.83	Other	47	110
593	FIB.interstitial.mesenchymal_APC	1.79e-03	Nonsignificant	0.95	0.80	Other	81	33
594	MAC.kupffer.fibrogenic	1.74e-03	Nonsignificant	—	0.00	Other	0	0
595	THYMO.CD8aa_IELp	1.66e-03	Nonsignificant	—	0.00	Other	1	7
596	T.CD8_Tem.motility_primed	1.61e-03	Nonsignificant	0.87	0.77	Other	269	4
597	FIB.adventitial.baseline	1.54e-03	Nonsignificant	0.91	0.94	Other	157	278
598	NK.cytokine_quiescent	1.50e-03	Nonsignificant	0.94	0.85	Other	623	1,062
599	FIB.interstitial.lipid_matrix	1.48e-03	Nonsignificant	0.95	0.90	Other	258	191
600	DC.cDC2.adhesion_signaling	1.47e-03	Nonsignificant	1.00	0.55	Other	35	9
601	T.CD4_Tcm.DC_interact	1.46e-03	Nonsignificant	0.95	0.74	Other	72	32
602	NK.adaptive_terminal_cytotoxic	1.45e-03	Nonsignificant	0.95	0.74	Other	485	802
603	T.CD8_naive.baseline	1.45e-03	Nonsignificant	0.70	1.08	Other	142	2
604	ASPC.stem_like_progenitor	1.44e-03	Nonsignificant	0.98	0.87	Other	300	842
605	PC.IgG_systemic.metabolic	1.41e-03	Nonsignificant	0.91	0.71	Other	46	63
606	MAC.alveolar.biosynthetic_sterol_heme	1.30e-03	Nonsignificant	1.00	0.15	Other	347	40
607	T.CD4_Tcm.synapse_dynamics	1.25e-03	Nonsignificant	0.95	0.66	Other	15	10
608	T.CD4_Tcm.APC_mimicry	1.24e-03	Nonsignificant	0.94	0.96	Other	54	43
609	B.naive.metabolic	1.21e-03	Nonsignificant	0.84	1.00	Other	50	79
610	OLG.myelinating_stress	1.20e-03	Nonsignificant	1.00	0.77	Other	232	62
611	NK.cytokine_tissue_activation	1.19e-03	Nonsignificant	0.90	0.86	Other	267	450
612	T.CD8_naive.nfkb_related	1.16e-03	Nonsignificant	0.70	1.17	Other	1	0
613	OLG.myelinating_mature	1.10e-03	Nonsignificant	1.00	0.83	Other	363	94
614	B.naive.purinergic	9.21e-04	Nonsignificant	0.84	1.02	Other	384	820
615	NK.adaptive_immature_precursor	7.67e-04	Nonsignificant	0.90	0.99	Other	358	111
616	B.naive.remodeling	7.54e-04	Nonsignificant	0.65	1.09	Other	135	230
617	T.CD8_naive.cytokine_dampened	6.87e-04	Nonsignificant	0.75	1.01	Other	71	4
618	FIB.adventitial.mito_secretory	6.53e-04	Nonsignificant	0.91	0.81	Other	21	7
619	T.CD8_naive.effector_transition	6.17e-04	Nonsignificant	0.70	1.08	Other	35	62
620	FIB.adventitial.inflammatory_activated	6.10e-04	Nonsignificant	0.99	0.70	Other	100	473
621	MAC.kupffer.inflammatory	5.35e-04	Nonsignificant	—	0.00	Other	7	4
622	B.naive.antigen_presenting_ready	5.02e-04	Nonsignificant	0.84	1.01	Other	48	73
623	T.CD8_naive.splicing_enriched	4.96e-04	Nonsignificant	0.89	0.86	Other	120	16
624	EPI.thymic_medullary.hormone_xeno_barrier	4.81e-04	Nonsignificant	—	0.00	Other	0	8
625	ADIPO.thermogenic	4.38e-04	Nonsignificant	—	0.00	Other	0	0
626	T.CD8_Trm.homeostatic	4.23e-04	Nonsignificant	1.00	0.49	Other	42	5
627	T.CD8_Tcm.baseline	4.14e-04	Nonsignificant	1.00	0.83	Other	90	89
628	MG.expanding	4.09e-04	Nonsignificant	0.87	0.79	Other	2	1
629	T.CD8_naive.mito_proteostasis	4.03e-04	Nonsignificant	0.70	1.18	Other	428	100
630	ADIPO.immature	3.79e-04	Nonsignificant	—	0.00	Other	24	40
631	B.naive.baseline	3.78e-04	Nonsignificant	0.84	0.98	Other	10	13
632	EPI.thymic_medullary.canonical_alarmin	3.50e-04	Nonsignificant	0.12	1.50	Other	8	17
633	T.CD8_transitional.stress	2.25e-04	Nonsignificant	—	0.00	Other	24	34
634	EPI.thymic_medullary.proliferative_APC	2.16e-04	Nonsignificant	—	0.22	Other	0	0
635	FIB.barrier_secretory.remodeling	2.14e-04	Nonsignificant	—	0.00	Other	0	0
636	B.age_associated.naive_transitional	1.69e-04	Nonsignificant	—	0.00	Other	0	0
637	T.CD8_naive.innate_like	1.57e-04	Nonsignificant	0.89	0.76	Other	10	1
638	EPI.thymic_medullary.stress_APC	1.35e-04	Nonsignificant	0.90	0.43	Other	2	4
639	T.CD8_naive.lipid_synthesis	1.32e-04	Nonsignificant	0.89	0.67	Other	6	4
640	CM.baseline	1.31e-04	Nonsignificant	1.00	1.00	Other	393	0
641	B.memory.baseline	1.15e-04	Nonsignificant	1.00	0.84	Other	472	99
642	MAC.resident_cardiac.inflammatory_reparative	7.99e-05	Nonsignificant	0.56	1.15	Other	31	96
643	B.memory.migratory	7.49e-05	Nonsignificant	1.00	0.89	Other	123	208
644	ILC2.activated	5.85e-05	Nonsignificant	—	0.00	Other	0	0
645	T.CD8_Tcm.gut_homing	5.68e-05	Nonsignificant	1.00	0.55	Other	380	112
646	ASTRO.stress_acute	5.13e-05	Nonsignificant	1.00	0.61	Other	60	56
647	FIB.neurolectin_mucosa.nerve_interface	3.81e-05	Nonsignificant	—	0.60	Other	4	0
648	ASPC.signal_integrator	3.53e-05	Nonsignificant	—	0.00	Other	0	0
649	EPI.salivary_serous_acinar.secretory_active	3.18e-05	Nonsignificant	1.00	3.72e-03	Other	242	69
650	FIB.neurolectin_mucosa.remodeling_repair	2.24e-05	Nonsignificant	—	0.33	Other	4	2
651	FIB.neurolectin_mucosa.axon_responsive	1.99e-05	Nonsignificant	0.16	1.40	Other	10	10
652	CM.mechano_activated	1.80e-05	Nonsignificant	1.00	1.05	Other	205	134
653	B.naive.proteostasis	1.77e-05	Nonsignificant	0.99	0.77	Other	49	69
654	MAC.microglia_like.patrolling_adhesive	1.75e-05	Nonsignificant	—	0.36	Other	0	0
655	ASTRO.A1_reactive	1.40e-05	Nonsignificant	1.00	0.35	Other	433	394
656	MAC.microglia_like.inflammatory_chemokine	1.38e-05	Nonsignificant	—	0.16	Other	20	32
657	FIB.neurolectin_mucosa.inflammatory	1.16e-05	Nonsignificant	0.43	1.08	Other	52	110
658	MAC.resident_cardiac.phagocytic_homeostasis	1.03e-05	Nonsignificant	0.56	1.02	Other	564	1,221
659	FIB.adventitial.activated_remodelling	8.17e-06	Nonsignificant	—	0.00	Other	141	319
660	B.naive.receptor_recycle	6.73e-06	Nonsignificant	0.99	0.65	Other	51	0
661	MAC.resident_cardiac.antigen_presenting	3.58e-06	Nonsignificant	0.56	1.01	Other	52	27
662	B.memory.pDC_imprint	3.12e-06	Nonsignificant	1.00	0.70	Other	157	103
663	MAC.microglia_like.phagocytic_redox	1.83e-06	Nonsignificant	—	0.00	Other	0	0
664	CM.osmoprotection	1.26e-06	Nonsignificant	1.00	1.03	Other	34	57
665	GRNLSA.angiocrine_mechanosensory	1.20e-06	Nonsignificant	—	0.00	Other	0	0
666	B.germinal_center.LZ_selection	1.18e-06	Nonsignificant	—	1.13	Other	0	0
667	B.germinal_center.DZ_M_phase	9.97e-07	Nonsignificant	—	0.37	Other	0	0
668	B.germinal_center.LZ_memory_precursor	7.76e-07	Nonsignificant	—	0.00	Other	0	0
669	CM.oxidative_phospho	4.24e-07	Nonsignificant	1.00	0.99	Other	266	792
670	CM.inflammatory	2.53e-07	Nonsignificant	—	1.40	Other	0	0
671	CM.mito_proteostasis	1.65e-07	Nonsignificant	1.00	0.99	Other	329	29
672	CM.sarcomere_actin_interface	1.54e-07	Nonsignificant	1.00	0.96	Other	450	78
673	SKM.type_2_fast.oxidative_IIa	1.51e-07	Nonsignificant	0.21	1.06	Other	946	56
674	B.germinal_center.DZ_S_phase	2.70e-08	Nonsignificant	—	0.00	Other	0	0
675	T.CD8_Tcm.NK_like	9.00e-09	Nonsignificant	1.00	0.04	Other	334	581
676	B.germinal_center.LZ_survival	5.52e-09	Nonsignificant	—	0.00	Other	0	0
677	SKM.type_1_slow.contractile	4.90e-09	Nonsignificant	0.60	1.04	Other	596	8
678	EPI.thymic_cortical.secretory_remodeling	2.08e-09	Nonsignificant	—	0.69	Other	4	1
679	CM.translation_boost_RPL	7.60e-10	Nonsignificant	1.00	0.95	Other	129	1
680	SKM.type_1_slow.glycolytic	7.19e-10	Nonsignificant	0.60	1.08	Other	362	647
681	SKM.type_2_fast.glycolytic_IIx_IIb	4.87e-10	Nonsignificant	0.68	0.94	Other	565	1,482
682	MAC.kupffer.metabolic	4.13e-10	Nonsignificant	—	0.00	Other	25	36
683	ADIPO.inflammatory	1.94e-11	Nonsignificant	—	0.00	Other	0	0
684	SKM.type_1_slow.oxidative	4.65e-12	Nonsignificant	0.93	0.82	Other	802	251
685	CM.anti_inflammatory	1.22e-12	Nonsignificant	1.00	0.85	Other	424	1,503
686	CM.translation_boost_RPS	3.00e-14	Nonsignificant	1.00	0.88	Other	69	16
687	EPI.thymic_cortical.Notch_interface	4.68e-15	Nonsignificant	—	0.05	Other	82	137
688	EPI.thymic_cortical.baseline	3.29e-15	Nonsignificant	0.88	0.40	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

245 unique genes. Showing 1–245. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
POU5F1	01-High	0.63	9.63	G1	C1	induced_pluripotent_stem_cell (L1), IPSC.induced_pluripotent_stem_cell (L1S), IPSC.canonical_pluripotent (L2), IPSC.endoderm_primed (L2)	EC.arterial.metabolic (Tier: specific)	10 cells — complete matches	107	259
GPSM3	01-High	0.63	12.44	G1	C1	—	EC.arterial.elastic (Tier: specific) EC.arterial.metabolic (Tier: specific) EC.liver_sinusoidal.secretory_lipoprotein (Tier: specific) EC.venous.remodeling_stalk (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant)	50 cells — complete matches	358	590
NOTCH4	01-High	0.61	10.75	G1	C1	—	EC.arterial.elastic (Tier: specific) EC.arterial.metabolic (Tier: specific) EC.liver_sinusoidal.secretory_lipoprotein (Tier: specific) EC.venous.remodeling_stalk (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant) EC.arterial.inflammatory (Tier: relevant) EC.liver_sinusoidal.stress (Tier: relevant)	36 cells — complete matches	143	264
ENSG00000273333	01-High	0.60	14.31	G1	C1	—	—	—	245	490
CFB	01-High	0.60	6.89	G1	C1	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2), MAC.LAM.lipid_opsonization (L2), MAC.alveolar.scavenging_endocytic (L2), MAC.resident_repair.ECM_stromal_crosstalk (L2)	EPI.renal_principal_cell (Tier: specific) CHOND.pro_inflammatory (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant) EPI.renal_proximal_tubule.onecarbon_peroxisome (Tier: relevant)	94 cells — complete matches	508	1,239
MICA	01-High	0.59	5.69	G1	C1	—	—	7 cells — complete matches	277	593
PSORS1C3	01-High	0.58	9.45	G1	C1	—	—	—	124	315
PRRC2A	01-High	0.57	12.27	G1	C1	—	—	—	110	204
MIR6832	01-High	0.57	12.02	G1	C1	—	—	—	99	170
FLOT1	01-High	0.55	2.62	G1	C1	—	—	EC.arterial.ion_pump (L2)	278	593
IER3	01-High	0.55	2.62	G1	C1	DC.cDC2.pro_inflammatory (L2), EPI.pancreatic_acinar.inflammatory_regenerative (L2), EPI.salivary_myoepithelial.activated (L2), EPI.skin_follicular_keratinizing.transit_amplifying (L2), FIB.barrier_purinergic.stress_GF_binding (L2), FIB.reticular.stress_metallothionein (L2), HEP.canalicular_transport.secretory_ERAD_UPR (L2), MAC.kupffer.inflammatory (L2), PC.IgG_systemic.interacting (L2), SCHWN.reactive_inflammatory (L2), T.CD4_Trm.activated (L2), T.CD8_Trm.inflammatory (L2)	—	85 cells — complete matches	247	484
CCHCR1	01-High	0.53	6.94	G1	C1	—	—	13 cells — complete matches	146	317
TCF19	01-High	0.53	6.25	G1	C1	EPI.esophageal_suprabasal.proliferative_S (L2), HEP.acute_phase.proliferative (L2)	—	46 cells — complete matches	196	428
PSORS1C1	01-High	0.51	7.13	G1	C1	—	EC.arterial.metabolic (Tier: specific) EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.intrahepatic_cholangiocyte_transport (Tier: relevant) EC.arterial.inflammatory (Tier: relevant) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	26 cells — complete matches	152	355
TSBP1-AS1	01-High	0.51	14.18	G1	C1	—	—	—	106	195
ENSG00000290574	01-High	0.50	3.28	G1	C1	—	—	—	55	94
PBX2	01-High	0.48	13.82	G1	C1	—	—	7 cells — complete matches	289	424
ENSG00000305139	01-High	0.48	14.49	G1	C1	—	—	—	154	224
AGER	01-High	0.46	14.28	G1	C1	EPI.alveolar_type_1 (L1S), EPI.alveolar_type_1.baseline (L2)	EC.arterial.elastic (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant)	39 cells — complete matches	164	276
HLA-DQB1	02-Medium	0.67	19.35	G1	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific)	133 cells — complete matches	703	1,314
CLIC1	02-Medium	0.62	14.64	G1	C2	PC.IgG_systemic.secretory (L2)	EC.venous.remodeling_stalk (Tier: specific)	10 cells — complete matches	159	256
AIF1	02-Medium	0.62	16.15	G1	C2	IPSC.mesodermal_primed (L2), T.CD4_Tcm.stress (L2)	—	118 cells — complete matches	433	801
ENSG00000307907	02-Medium	0.61	15.16	G1	C2	—	—	—	489	1,000
ENSG00000303029	02-Medium	0.60	14.16	G1	C2	—	—	—	234	380
TAP2	02-Medium	0.60	15.28	G1	C2	—	—	10 cells — complete matches	198	364
SAPCD1-AS1	02-Medium	0.60	14.93	G1	C2	—	—	MAC.LAM.perivascular_angiocrine (L2)	27	56
LY6G5B	02-Medium	0.59	13.87	G2	C1	—	—	26 cells — complete matches	11	17
ENSG00000263020	02-Medium	0.59	13.53	G2	C1	—	—	—	54	128
SNHG32	02-Medium	0.58	16.69	G2	C2	—	—	—	38	69
HLA-DRA	02-Medium	0.57	15.27	G1	C2	B_cell (L1), dendritic_cell (L1), DC.mig (L1S), EC.capillary.postcap_venule (L2), EPI.renal_distal_tubule.stress (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MAC.resident_repair.antigen_presenting (L2), MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	EC.arterial.metabolic (Tier: specific) EC.venous.remodeling_stalk (Tier: specific)	194 cells — complete matches	693	1,237
HCP5	02-Medium	0.57	13.66	G1	C2	—	—	—	510	867
RNF5	02-Medium	0.55	14.27	G2	C2	—	—	SKM.type_1_slow (L1S), EPI.salivary_serous_acinar.secretory_active (L2), SKM.type_1_slow.oxidative (L2)	128	173
BAG6	02-Medium	0.55	13.06	G2	C1	—	—	MONO.CD16.inflammatory (L2)	73	116
ENSG00000233902	02-Medium	0.55	12.55	G1	C2	—	—	—	150	247
ENSG00000250264	02-Medium	0.55	11.29	G1	C2	—	—	—	198	364
ENSG00000289047	02-Medium	0.55	8.24	G1	C2	—	—	—	248	377
HCG27	02-Medium	0.55	10.29	G1	C2	—	EC.venous.remodeling_stalk (Tier: specific)	37 cells — complete matches	119	287
HLA-G	02-Medium	0.55	4.29	G1	C2	—	—	33 cells — complete matches	74	109
NFKBIL1	02-Medium	0.54	9.89	G2	C1	—	—	4 cells — complete matches	101	243
ENSG00000289559	02-Medium	0.54	7.32	G1	C2	—	—	—	131	232
SNORD52	02-Medium	0.54	13.25	G2	C2	—	—	—	32	55
GPANK1	02-Medium	0.54	12.96	G1	C2	—	—	6 cells — complete matches	27	43
ENSG00000301753	02-Medium	0.54	12.76	G2	C2	—	—	—	8	24
HLA-DOB	02-Medium	0.53	17.66	G2	C2	—	—	64 cells — complete matches	135	235
HLA-DQB2	02-Medium	0.53	12.06	G1	C2	—	—	60 cells — complete matches	205	497
TRIM31	02-Medium	0.53	6.71	G1	C2	EPI.colonocyte.distal_absorptive (L2)	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: relevant)	30 cells — complete matches	82	107
MICB	02-Medium	0.53	13.80	G1	C2	—	EC.arterial.elastic (Tier: specific)	43 cells — complete matches	294	633
HLA-DQA1	02-Medium	0.52	17.78	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), MAC.resident_iron.APC_iron_sensing (L2), MONO.CD14.APC_like (L2), MONO.CD16.hepatic_mac_like (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2)	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	159 cells — complete matches	608	1,232
PPT2-EGFL8	02-Medium	0.52	13.81	G2	C2	—	—	14 cells — complete matches	52	132
VWA7	02-Medium	0.52	13.63	G2	C2	—	—	26 cells — complete matches	1	1
MCCD1	02-Medium	0.52	8.89	G2	C1	—	—	—	35	113
CSNK2B	02-Medium	0.51	11.58	G2	C2	—	—	—	54	128
AGPAT1	02-Medium	0.51	13.17	G2	C2	—	—	6 cells — complete matches	27	58
ENSG00000309733	02-Medium	0.51	17.34	G2	C2	—	—	—	468	929
HLA-DRB1	02-Medium	0.51	17.49	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), FIB.reticular.immune_interface (L2), MAC.resident_cardiac.antigen_presenting (L2), MAC.resident_repair.antigen_presenting (L2), MG.phagocytic_APC (L2), MONO.CD14.APC_like (L2), NK.adaptive_axis_baseline (L2), NK.adaptive_biosynthetic_primed (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Tfh.effector_migratory (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	EC.arterial.elastic (Tier: specific) EC.arterial.metabolic (Tier: specific) EC.venous.remodeling_stalk (Tier: specific) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EC.arterial.inflammatory (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	203 cells — complete matches	565	1,192
ENSG00000285761	02-Medium	0.50	4.96	G1	C2	—	—	—	123	218
APOM	02-Medium	0.50	13.35	G2	C2	EPI.ileal_bile_transport.absorptive_xenobiotic (L2)	EPI.renal_proximal_tubule.onecarbon_peroxisome (Tier: relevant)	13 cells — complete matches	14	16
ENSG00000272236	02-Medium	0.50	4.57	G1	C2	—	—	—	38	69
DDX39B	02-Medium	0.50	10.90	G2	C1	—	—	—	112	383
HLA-F-AS1	02-Medium	0.50	4.42	G1	C2	—	—	—	199	357
ENSG00000299747	02-Medium	0.50	12.64	G1	C2	—	—	—	346	745
SNORD84	02-Medium	0.49	11.27	G2	C1	—	—	—	59	180
ZSCAN31	02-Medium	0.49	3.21	G1	C2	—	EC.arterial.elastic (Tier: specific) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	19 cells — complete matches	28	78
MSH5-SAPCD1	02-Medium	0.49	14.26	G2	C2	—	—	15 cells — complete matches	7	13
MICB-DT	02-Medium	0.49	13.06	G1	C2	—	—	—	131	286
PRRT1	02-Medium	0.49	14.63	G2	C2	—	EC.arterial.elastic (Tier: specific) EC.arterial.metabolic (Tier: specific) EC.arterial.inflammatory (Tier: relevant)	26 cells — complete matches	51	133
ATP6V1G2	02-Medium	0.49	10.02	G2	C2	—	—	12 cells — complete matches	73	194
EHMT2	02-Medium	0.49	12.37	G2	C2	—	—	5 cells — complete matches	47	89
ATP6V1G2-DDX39B	02-Medium	0.49	9.87	G2	C2	—	—	11 cells — complete matches	69	185
STK19	02-Medium	0.49	7.68	G2	C1	—	—	12 cells — complete matches	35	52
PSMB8-AS1	02-Medium	0.48	10.39	G1	C2	—	EC.arterial.metabolic (Tier: specific) EC.venous.remodeling_stalk (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant)	10 cells — complete matches	204	380
DDX39B-AS1	02-Medium	0.48	10.25	G2	C1	—	—	12 cells — complete matches	56	182
ENSG00000299760	02-Medium	0.48	10.25	G2	C1	—	—	—	56	182
ENSG00000294466	02-Medium	0.48	12.60	G1	C2	—	—	—	58	138
C6orf47	02-Medium	0.48	11.73	G2	C2	—	—	11 cells — complete matches	86	156
PSMB8	02-Medium	0.48	9.87	G1	C2	—	EC.venous.remodeling_stalk (Tier: specific)	5 cells — complete matches	200	385
MTMR4	02-Medium	0.47	7.64	G1	C2	—	—	12 cells — complete matches	9	11
SEPTIN4	02-Medium	0.47	6.80	G1	C2	—	—	—	15	23
NELFE	02-Medium	0.47	6.10	G1	C2	—	—	—	66	84
MIR21	02-Medium	0.47	7.37	G2	C1	—	—	—	0	0
BCAS3-AS1	02-Medium	0.46	3.19	G1	C2	—	—	—	3	4
PPT2	02-Medium	0.46	9.30	G2	C2	—	—	14 cells — complete matches	52	132
ENSG00000286974	02-Medium	0.46	10.79	G1	C2	—	—	—	95	225
SLC44A4	02-Medium	0.46	10.73	G2	C2	EPI.hepatic_ductular_cholangiocyte.ion_transport (L2), EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (L2), EPI.pancreatic_ductal_bicarbonate.barrier_mucin (L2)	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.pancreatic_ductal_mucinous (Tier: relevant) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	46 cells — complete matches	23	31
TAP1	02-Medium	0.46	7.96	G1	C2	EPI.thymic_cortical.baseline (L2)	—	ASPC.inflammatory (L2), GRANU.neutrophil.antiviral_endotoxin (L2), HEP.periportal_metabolic.acute_phase_barrier (L2)	201	382
ENSG00000299769	02-Medium	0.45	15.68	G2	C2	—	—	—	333	727
PSMB9	02-Medium	0.45	7.96	G1	C2	—	EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	21 cells — complete matches	227	422
ENSG00000293479	02-Medium	0.45	11.80	G1	C2	—	—	—	1	15
LY6G6E	02-Medium	0.45	11.80	G1	C2	—	—	—	1	15
MPIG6B	02-Medium	0.45	11.85	G2	C2	MONO.CD14.platelet_bound (L2), MONO.CD16.platelet_bound (L2)	—	27 cells — complete matches	1	15
ENSG00000204422	02-Medium	0.45	11.66	G1	C2	—	—	—	1	15
HCG9	02-Medium	0.45	3.54	G1	C2	—	—	10 cells — complete matches	46	80
RPS6KB1	02-Medium	0.45	9.38	G1	C2	—	—	4 cells — complete matches	18	25
IGBP1C	02-Medium	0.45	6.88	G2	C2	—	—	—	0	0
ENSG00000308764	02-Medium	0.44	9.01	G1	C2	—	—	—	14	21
TUBD1	02-Medium	0.44	9.01	G1	C2	—	—	8 cells — complete matches	14	21
HLA-DQA2	02-Medium	0.44	13.76	G2	C2	T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2)	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	127 cells — complete matches	173	495
POLR1HASP.2	02-Medium	0.44	3.75	G1	C2	—	—	—	341	670
TEX14	02-Medium	0.44	6.40	G2	C2	—	—	6 cells — complete matches	7	12
RNFT1-DT	02-Medium	0.44	8.47	G2	C2	—	—	—	0	0
GNL1	02-Medium	0.44	1.12	G2	C1	—	—	—	74	175
SUPT4H1	02-Medium	0.44	6.14	G2	C2	—	—	FIB.perivascular_interface (L1S), EC.capillary.angiogenic_tip (L2), HEP.pericentral_lipoprotein.ApoB_coagulation (L2)	16	52
ZBTB12	02-Medium	0.44	14.36	G2	C2	—	—	12 cells — complete matches	24	33
LY6G6D	02-Medium	0.43	11.80	G1	C2	—	—	—	9	22
SKIC2	02-Medium	0.43	7.13	G1	C2	—	—	—	63	108
ENSG00000289375	02-Medium	0.43	12.01	G2	C2	—	—	—	0	0
HLA-C	02-Medium	0.43	7.18	G1	C2	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	EC.arterial.metabolic (Tier: specific) EC.arterial.inflammatory (Tier: relevant)	76 cells — complete matches	738	1,070
ENSG00000307923	02-Medium	0.43	6.74	G1	C2	—	—	—	371	796
SEPTIN4-AS1	02-Medium	0.43	6.43	G1	C2	—	—	—	10	18
ENSG00000298801	02-Medium	0.43	4.31	G1	C2	—	—	—	104	221
VARS2	02-Medium	0.43	4.67	G1	C2	—	—	11 cells — complete matches	62	90
SFTA2	02-Medium	0.43	4.58	G2	C1	EPI.alveolar_type_1.baseline (L2), EPI.lung_club_secretory.canonical_surfactant (L2)	EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific)	23 cells — complete matches	53	143
MSH5	02-Medium	0.43	9.30	G2	C2	—	—	13 cells — complete matches	7	14
RAD51C	02-Medium	0.43	5.70	G2	C2	—	EC.venous.remodeling_stalk (Tier: specific)	7 cells — complete matches	0	0
ENSG00000224738	02-Medium	0.42	7.83	G1	C2	—	—	—	4	14
ENSG00000303842	02-Medium	0.42	6.84	G1	C2	—	—	—	0	0
GDPD1	02-Medium	0.42	13.51	G2	C2	—	—	28 cells — complete matches	2	5
AP4B1	02-Medium	0.42	7.94	G2	C2	—	—	9 cells — complete matches	72	150
TRIM39	02-Medium	0.42	7.66	G2	C2	—	—	9 cells — complete matches	21	56
TSPOAP1-AS1	02-Medium	0.42	4.75	G2	C2	—	—	49 cells — complete matches	6	11
MIR142	02-Medium	0.42	5.20	G2	C2	—	—	—	15	71
MIR142HG	02-Medium	0.42	5.20	G2	C2	—	—	—	15	71
PTPN22	02-Medium	0.41	7.89	G1	C2	—	—	97 cells — complete matches	73	148
ENSG00000296065	02-Medium	0.41	4.71	G1	C2	—	—	—	130	282
ZSCAN12	02-Medium	0.41	3.48	G1	C2	—	—	17 cells — complete matches	33	87
SNORD48	02-Medium	0.41	9.30	G2	C2	—	—	—	1	6
DCLRE1B	02-Medium	0.41	7.14	G2	C2	—	—	26 cells — complete matches	73	148
TSPOAP1	02-Medium	0.41	4.63	G2	C2	—	—	34 cells — complete matches	4	10
ENSG00000302963	02-Medium	0.41	4.66	G2	C2	—	—	—	6	10
MIR4736	02-Medium	0.41	4.66	G2	C2	—	—	—	6	10
MICE	02-Medium	0.41	4.47	G1	C2	—	—	—	91	188
EHMT2-AS1	02-Medium	0.41	7.88	G2	C2	—	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: specific) EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.pancreatic_ductal_mucinous (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	16 cells — complete matches	4	5
DDR1	02-Medium	0.40	3.82	G2	C2	—	—	10 cells — complete matches	121	263
ENSG00000289282	02-Medium	0.40	13.24	G2	C2	—	—	—	0	0
HSPA1B	02-Medium	0.40	13.69	G2	C2	ASTRO.stress_acute (L2), B.memory.activated (L2), B.naive.activated (L2), DC.cDC2.tolerogenic_regulatory (L2), EC.capillary.inflammatory (L2), EC.liver_sinusoidal.stress (L2), EPI.alveolar_type_2.stress_response (L2), EPI.colonocyte.crypt_progenitor (L2), EPI.pancreatic_acinar.stress (L2), EPI.pancreatic_ductal_bicarbonate.stress (L2), EPI.renal_distal_tubule.stress (L2), EPI.renal_principal_cell.activated_acute (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), EPI.tracheal_basal.activated_stress (L2), FIB.skin_sheath.stress_chaperone (L2), GRNLSA.EMT_insulin_signaling (L2), HEP.canalicular_transport.inflammatory (L2), ILC2.activated (L2), MAC.kupffer.stress (L2), MONO.CD14.cord_tolerance (L2), OLG.stress (L2), PC.IgA_muocsal.plasmablast (L2), SMC.activated (L2), T.CD8_Trm.inflammatory (L2), T.CD8_transitional.stress (L2), T.MAIT.stress (L2), THYMO.DP_early_stress (L2), THYMO.SP_CD8_naive_stress (L2)	EC.liver_sinusoidal.stress (Tier: relevant) EPI.renal_principal_cell.activated_acute (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant)	88 cells — complete matches	60	376
SMG8	02-Medium	0.40	9.41	G2	C2	—	EC.arterial.angiogenic_tip (Tier: relevant)	26 cells — complete matches	3	14
ENSG00000310474	02-Medium	0.40	3.53	G1	C2	—	—	—	16	19
ZNF165	02-Medium	0.40	2.62	G2	C2	EPI.hepatic_ductular_cholangiocyte.stress (L2)	EPI.renal_distal_tubule (Tier: relevant) EPI.renal_distal_tubule.immune_modulatory (Tier: relevant)	93 cells — complete matches	19	48
HLA-A	02-Medium	0.40	3.71	G1	C2	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.renal_principal_cell.injury_repair (L2), EPI.skin_appendage_keratinocyte.ductal_immune_interacting (L2), FIB.skin_sheath.ECM_immune (L2), HEP.pericentral_lipoprotein.ApoB_coagulation (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	EC.arterial.metabolic (Tier: specific) EC.arterial.inflammatory (Tier: relevant)	78 cells — complete matches	281	510
TNXB	02-Medium	0.39	12.67	G2	C2	GRANU.neutrophil.antiviral_endotoxin (L2)	—	27 cells — complete matches	153	526
ENSG00000301898	02-Medium	0.39	9.30	G2	C2	—	—	—	0	0
HLA-F	02-Medium	0.39	4.73	G1	C2	EPI.skin_appendage_keratinocyte.ductal_immune_interacting (L2)	EC.arterial.metabolic (Tier: specific)	11 cells — complete matches	205	352
LST1	02-Medium	0.39	8.46	G2	C1	granulocyte (L1), macrophage (L1), monocyte (L1), MAC.MDM (L1S), MONO.CD16 (L1S), ILC2.activated (L2), MAC.MDM.inflammatory_phagocytic (L2), MONO.CD14.baseline (L2)	EC.arterial.angiogenic_tip (Tier: relevant)	106 cells — complete matches	183	440
TRIM39-RPP21	02-Medium	0.39	6.57	G2	C2	—	—	30 cells — complete matches	0	0
ENSG00000285897	02-Medium	0.39	6.01	G2	C2	—	—	—	3	8
LY6G5C	02-Medium	0.39	12.08	G2	C2	—	EC.arterial.elastic (Tier: specific)	30 cells — complete matches	38	57
NEU1	02-Medium	0.39	10.56	G2	C2	—	—	7 cells — complete matches	26	37
C2	02-Medium	0.39	9.48	G2	C2	EPI.alveolar_type_2.baseline_surfactant (L2), EPI.alveolar_type_2.stress_response (L2), HEP.pericentral_lipoprotein.ApoB_coagulation (L2)	—	49 cells — complete matches	61	83
GTF2H4	02-Medium	0.39	4.17	G2	C2	—	—	4 cells — complete matches	61	160
AP4B1-AS1	02-Medium	0.39	7.36	G1	C2	—	—	34 cells — complete matches	73	147
TNF	02-Medium	0.39	6.48	G2	C2	B.naive.activated (L2), EC.capillary.inflammatory (L2), EPI.ectocervical_granular.inflammatory (L2), EPI.renal_principal_cell.inflammatory (L2), ILC2.activated (L2), MAC.alveolar.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2), T.CD4_Trm.activated (L2), T.CD4_cytotoxic.NK_adapted (L2), T.CD8_Trm.inflammatory (L2)	EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EPI.intrahepatic_cholangiocyte_transport (Tier: relevant) EPI.renal_distal_tubule (Tier: relevant) EPI.renal_distal_tubule.immune_modulatory (Tier: relevant) EPI.renal_principal_cell.inflammatory (Tier: relevant)	111 cells — complete matches	75	194
HSF5	02-Medium	0.39	5.33	G1	C2	—	—	—	4	13
RNF43	02-Medium	0.38	5.26	G2	C2	EPI.colonocyte.crypt_progenitor (L2)	—	23 cells — complete matches	3	8
LTA	02-Medium	0.38	6.48	G1	C2	—	—	105 cells — complete matches	226	418
HCG20	02-Medium	0.38	4.19	G1	C2	EPI.ectocervical_granular.inflammatory (L2), EPI.pancreatic_acinar.inflammatory_regenerative (L2)	—	38 cells — complete matches	183	351
PPM1J	02-Medium	0.38	6.73	G1	C2	—	—	26 cells — complete matches	11	45
ENSG00000289406	02-Medium	0.38	6.82	G1	C2	—	—	—	201	390
TUBB	02-Medium	0.38	0.79	G1	C2	CHOND.activated_fibro_like (L2), DC.cDC1.proliferative (L2), DC.cDC2.proliferative (L2), EPI.colonic_enteroendocrine.progenitor (L2), EPI.ileal_goblet.immature (L2), OLG.reactive_repair (L2), THYMO.proliferative_S (L2)	—	8 cells — complete matches	165	310
RPL7A	02-Medium	0.38	2.31	G1	C2	—	EC.venous.remodeling_stalk (Tier: specific)	40 cells — complete matches	107	152
SNORD24	02-Medium	0.38	2.31	G1	C2	—	—	—	106	151
ZKSCAN8P1	02-Medium	0.38	2.53	G1	C2	—	—	—	26	99
MOV10	02-Medium	0.37	1.05	G1	C2	—	—	14 cells — complete matches	32	115
ENSG00000225864	02-Medium	0.37	3.14	G1	C2	—	—	—	140	236
ENSG00000290870	02-Medium	0.37	6.42	G2	C2	—	—	—	4	4
HIPK1-AS1	02-Medium	0.37	7.45	G2	C2	—	—	23 cells — complete matches	72	153
ZDHHC20P1	02-Medium	0.37	4.96	G2	C2	—	—	—	140	226
HIPK1	02-Medium	0.37	7.32	G2	C2	—	—	29 cells — complete matches	72	153
LTB	02-Medium	0.37	6.70	G2	C1	T.CD4_Tcm (L1S), T.CD4_Tem (L1S), T.CD4_transitional (L1S), T.CD8_Tcm (L1S), T.CD8_transitional (L1S), B.germinal_center.LZ_survival (L2), DC.mig.baseline (L2), HPC.CLP_B_primed (L2), ILC2.activated (L2), T.CD4_Trm.helper_like (L2), T.CD4_cytotoxic.precursor (L2), T.CD8_naive.baseline (L2), T.gamma_delta.central_memory (L2), THYMO.SP_CD8_naive (L2)	EPI.renal_thick_ascending_limb (Tier: specific) EPI.renal_thick_ascending_limb.barrier_repair (Tier: specific) EPI.intrahepatic_cholangiocyte_transport (Tier: relevant)	165 cells — complete matches	127	281
ST7L	02-Medium	0.37	2.59	G2	C2	—	—	EPI.cervical_suprabasal.secretory_vesicle (L2), T.CD4_Tcm.tissue_homing (L2), T.CD8_transitional.Trm_primed (L2)	16	38
NCR3	02-Medium	0.37	8.82	G1	C2	T.CD4_transitional.tissue_enagement (L2), T.CD8_Tcm.NK_like (L2), T.CD8_Tem.TEMRA (L2)	—	104 cells — complete matches	261	542
ZSCAN16-AS1	02-Medium	0.37	2.75	G2	C2	—	—	B.naive.baseline (L2)	19	48
RSBN1	02-Medium	0.36	8.35	G1	C2	—	—	B.age_associated.migratory (L2), B.naive.receptor_recycle (L2), T.CD8_Tcm.gut_homing (L2)	71	146
ENSG00000296082	02-Medium	0.36	4.44	G1	C2	—	—	—	136	282
HCG4P8	02-Medium	0.36	3.28	G2	C2	—	—	—	3	2
MKS1	02-Medium	0.36	4.53	G2	C2	—	—	17 cells — complete matches	0	2
ENSG00000280128	02-Medium	0.36	8.14	G2	C2	—	—	—	0	0
ENSG00000310015	02-Medium	0.35	3.49	G2	C2	—	—	—	0	0
ENSG00000308485	02-Medium	0.35	9.33	G2	C2	—	—	—	9	11
ENSG00000306378	02-Medium	0.35	6.07	G2	C2	—	—	—	76	375
ENSG00000300690	02-Medium	0.34	5.95	G2	C2	—	—	—	23	59
BCL2L15	02-Medium	0.34	7.37	G1	C2	—	EPI.pancreatic_acinar.metabolic_onecarbon (Tier: specific) EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	29 cells — complete matches	72	147
ENSG00000290051	02-Medium	0.34	3.38	G2	C2	—	—	—	0	0
MPO	02-Medium	0.34	3.17	G2	C2	HPC.GMP_granulocytic (L2)	—	22 cells — complete matches	17	50
HCG14	02-Medium	0.34	5.86	G2	C2	—	—	16 cells — complete matches	23	59
POLR1H	02-Medium	0.34	2.43	G2	C2	—	—	—	134	224
ENSG00000225075	02-Medium	0.34	1.20	G1	C2	—	—	—	12	45
ENSG00000290039	02-Medium	0.34	6.57	G2	C2	—	—	—	3	1
ENSG00000299124	02-Medium	0.33	5.65	G2	C2	—	—	—	23	59
HCG18	02-Medium	0.33	8.61	G2	C2	—	—	4 cells — complete matches	45	77
ENSG00000307176	02-Medium	0.33	9.13	G2	C2	—	—	—	10	11
MED22	02-Medium	0.33	2.45	G2	C2	—	—	22 cells — complete matches	29	42
HLA-L	02-Medium	0.33	9.59	G2	C2	—	—	—	76	108
HLA-L.2	02-Medium	0.33	9.59	G2	C2	—	—	—	76	108
CAPZA1	02-Medium	0.33	1.51	G1	C2	GRNLSA.stress_metabolic (L2)	—	MAC.resident_iron.stress_tolerogenic (L2)	16	60
LINC01623	02-Medium	0.33	5.97	G2	C2	—	—	—	23	59
H3C12	02-Medium	0.33	3.68	G2	C2	—	—	—	1	9
ENSG00000302104	02-Medium	0.33	4.28	G2	C2	—	—	—	5	16
GPR89P	02-Medium	0.33	4.28	G2	C2	—	—	—	5	16
EPX	02-Medium	0.33	4.59	G2	C2	—	—	DC.mig (L1S), DC.mig.baseline (L2)	1	1
RHOC	02-Medium	0.33	1.40	G1	C2	CHOND.articular_collagen (L2), EC.lymphatic.tip_migratory (L2)	—	27 cells — complete matches	29	113
MOG	02-Medium	0.32	3.97	G2	C2	oligodendrocyte (L1), OLG.oligodendrocyte (L1S)	—	10 cells — complete matches	6	8
VMP1	02-Medium	0.32	7.88	G2	C2	EPI.pancreatic_acinar.inflammatory_regenerative (L2), FIB.adventitial.inflammatory_activated (L2), GRANU.neutrophil.primed_degranulation (L2)	EPI.intrahepatic_cholangiocyte_defense (Tier: relevant) EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	16 cells — complete matches	9	11
ENSG00000287337	02-Medium	0.32	2.67	G2	C2	—	—	—	0	5
PPM1J-DT	02-Medium	0.32	2.53	G1	C2	—	—	—	10	43
ENSG00000225173	02-Medium	0.31	5.82	G2	C2	—	—	—	23	59
TRIM27	02-Medium	0.31	5.73	G2	C2	—	—	T.CD4_Tfh (L1S), B.naive.receptor_recycle (L2), MAC.resident_repair.antigen_presenting (L2)	44	103
SURF4	02-Medium	0.31	1.85	G1	C2	—	—	EPI.alveolar_type_1.baseline (L2), ILC2.migratory (L2)	29	41
NKAPL	02-Medium	0.30	2.90	G2	C2	—	EC.arterial.elastic (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant)	17 cells — complete matches	0	0
HLA-H	02-Medium	0.30	4.86	G2	C2	—	—	—	204	363
HLA-H.2	02-Medium	0.30	4.86	G2	C2	—	—	—	204	363
HLA-V.2	02-Medium	0.30	4.23	G2	C2	—	—	—	18	22
HCG4	02-Medium	0.30	3.91	G2	C2	—	—	—	13	17
ENSG00000310496	02-Medium	0.30	3.65	G2	C2	—	—	—	112	169
HLA-K	02-Medium	0.30	3.65	G2	C2	—	—	—	112	169
STKLD1	02-Medium	0.29	1.64	G1	C2	—	—	14 cells — complete matches	29	41
HLA-V	02-Medium	0.29	3.80	G2	C2	—	—	—	8	13
ENSG00000303124	02-Medium	0.29	1.15	G2	C2	—	—	—	39	94
LINC02569	02-Medium	0.29	1.06	G2	C2	—	—	—	41	82
HCG4B	02-Medium	0.29	3.45	G2	C2	—	—	—	11	10
ENSG00000310508	02-Medium	0.29	3.44	G2	C2	—	—	—	14	19
ENSG00000272501	02-Medium	0.29	9.69	G2	C2	—	—	—	151	319
ENSG00000230521	02-Medium	0.29	4.25	G2	C2	—	—	—	19	28
HLA-J	02-Medium	0.29	3.28	G2	C2	—	—	—	54	90
IER3-AS1	02-Medium	0.28	2.73	G2	C2	—	—	—	155	290
WNT2B	02-Medium	0.28	3.76	G2	C2	FIB.barrier_secretory (L1S), FIB.suburothelial (L1S)	—	25 cells — complete matches	7	8
ENSG00000298457	02-Medium	0.27	10.11	G2	C2	—	—	—	51	155
SURF2	02-Medium	0.27	2.24	G1	C2	—	—	—	35	74
LINC00243	02-Medium	0.27	3.10	G2	C2	—	—	78 cells — complete matches	192	416
SURF1	02-Medium	0.27	2.06	G1	C2	—	—	T.CD4_Tcm.APC_mimicry (L2)	27	40
HLA-E	02-Medium	0.26	1.17	G2	C2	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.thymic_cortical.baseline (L2), EPI.thymic_medullary.stress_APC (L2), FIB.interstitial.immune_interact (L2), THYMO.SP_CD4_naive (L2)	EC.arterial.metabolic (Tier: specific) EC.arterial.angiogenic_tip (Tier: relevant) EC.arterial.inflammatory (Tier: relevant)	37 cells — complete matches	193	384
ZFP57	02-Medium	0.26	3.70	G2	C2	—	—	34 cells — complete matches	59	109
ENSG00000301820	02-Medium	0.26	4.19	G2	C2	—	—	—	16	17
SNORD36A	02-Medium	0.26	2.31	G1	C2	—	—	—	28	41
SNORD36B	02-Medium	0.26	2.31	G1	C2	—	—	—	28	41
SNORD36C	02-Medium	0.26	2.31	G1	C2	—	—	—	28	41
ENSG00000293879	02-Medium	0.26	3.30	G2	C2	—	—	—	152	319
RPP21	02-Medium	0.26	7.01	G2	C2	—	—	—	1	1
DDX39BP2	02-Medium	0.26	2.94	G2	C2	—	—	—	3	2
ENSG00000310512	02-Medium	0.26	2.94	G2	C2	—	—	—	3	2
REXO4	02-Medium	0.26	1.95	G2	C2	—	—	6 cells — complete matches	45	64
ADAMTS13	02-Medium	0.25	2.47	G2	C2	—	—	20 cells — complete matches	37	50
SURF6	02-Medium	0.25	2.14	G1	C2	—	—	7 cells — complete matches	27	40
CACFD1	02-Medium	0.25	2.94	G1	C2	—	—	12 cells — complete matches	52	72
LPO	02-Medium	0.24	4.20	G2	C2	—	—	15 cells — complete matches	0	0
ENSG00000288805	02-Medium	0.24	1.59	G2	C2	—	—	—	32	64

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.