Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000071 · All tissues

Allergic rhinitis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Allergic rhinitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	T_cell	17.15	Significant	3.30e-49	1.42	Specific	470	959
2	innate_lymphoid_cell_2	16.52	Significant	1.00	1.20	Relevant	3	8
3	B_cell	3.26	Nominal	1.00	0.87	Other	356	694
4	thymocyte	2.70	Nonsignificant	1.00	0.84	Other	168	512
5	natural_killer_cell	2.67	Nonsignificant	1.00	0.87	Other	1,204	2,052
6	skeletal_muscle_cell	2.55	Nonsignificant	1.00	0.92	Other	944	2,600
7	macrophage	2.28	Nonsignificant	1.00	0.85	Other	813	1,732
8	monocyte	1.53	Nonsignificant	1.00	0.67	Other	2,176	3,871
9	granulocyte	1.43	Nonsignificant	1.00	0.76	Other	5	6
10	dendritic_cell	1.35	Nonsignificant	1.00	0.69	Other	496	724
11	mesothelial_cell	1.23	Nonsignificant	1.00	0.82	Other	6	36
12	haematopoietic_progenitor_cell	1.04	Nonsignificant	1.00	0.63	Other	262	502
13	hepatocyte	0.97	Nonsignificant	1.00	0.63	Other	1,515	3,822
14	adipocyte	0.95	Nonsignificant	1.00	0.74	Other	33	111
15	schwann_cell	0.90	Nonsignificant	1.00	0.58	Other	10	57
16	endothelial_cell	0.82	Nonsignificant	1.00	0.64	Other	373	974
17	adipose_stem_and_progenitor_cell	0.56	Nonsignificant	1.00	0.57	Other	327	954
18	granulosa_cell	0.52	Nonsignificant	1.00	0.55	Other	293	670
19	astrocyte	0.51	Nonsignificant	1.00	0.57	Other	256	1,203
20	fibroblast	0.32	Nonsignificant	1.00	0.46	Other	184	826
21	epithelial_cell	0.30	Nonsignificant	1.00	0.48	Other	24	47
22	microglia	0.26	Nonsignificant	1.00	0.46	Other	61	129
23	plasma_cell	0.25	Nonsignificant	1.00	0.45	Other	17	24
24	platelet	0.24	Nonsignificant	—	0.00	Other	85	104
25	chondrocyte	0.20	Nonsignificant	1.00	0.42	Other	548	1,069
26	muscle_stem_cell	0.17	Nonsignificant	1.00	0.44	Other	7	27
27	smooth_muscle_cell	0.08	Nonsignificant	1.00	0.37	Other	27	139
28	pericyte	0.02	Nonsignificant	1.00	0.31	Other	128	517
29	neuron	6.35e-03	Nonsignificant	1.00	0.31	Other	330	1,328
30	melanocyte	3.06e-03	Nonsignificant	1.00	0.25	Other	97	309
31	induced_pluripotent_stem_cell	1.14e-03	Nonsignificant	1.00	0.22	Other	0	0
32	cardiomyocyte	8.20e-04	Nonsignificant	1.00	0.24	Other	533	2,045
33	oligodendrocyte_precursor_cell	7.05e-04	Nonsignificant	1.00	0.22	Other	461	1,454
34	oligodendrocyte	2.68e-04	Nonsignificant	1.00	0.23	Other	385	1,507

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	T.CD4_naive	30.57	Significant	1.60e-49	2.19	Specific	399	866
2	T.CD8_naive	22.45	Significant	6.66e-08	1.42	Specific	317	708
3	T.CD4_Tcm	20.96	Significant	2.25e-03	1.24	Specific	494	988
4	T.CD4_Trm	18.37	Significant	1.00	1.02	Specific	176	363
5	T.CD4_Th17	16.93	Significant	1.00	0.93	Specific	421	794
6	ILC2.innate_lymphoid_cell_2	16.52	Significant	—	—	—	2	0
7	MAC.alveolar	15.67	Significant	5.26e-12	1.46	Specific	1,432	3,122
8	T.CD8_Tcm	13.20	Significant	1.00	0.77	Specific	460	926
9	T.CD4_Tfh	11.01	Significant	1.00	0.46	—	47	45
10	T.CD4_transitional	10.39	Significant	1.00	0.52	Relevant	48	110
11	B.germinal_center	9.56	Significant	1.76e-05	2.16	Specific	233	655
12	T.CD4_Tem	9.22	Significant	1.00	0.40	Relevant	365	697
13	T.CD8_Trm	8.91	Significant	1.00	0.47	Relevant	211	346
14	T.CD4_Treg	8.87	Significant	1.00	0.37	Relevant	244	511
15	T.MAIT	8.38	Significant	1.00	0.57	Relevant	469	855
16	DC.mig	6.65	Significant	—	1.92	Relevant	89	156
17	T.CD8_transitional	5.90	Significant	1.00	0.13	Other	497	932
18	T.gamma_delta	5.52	Significant	1.00	0.23	Other	588	1,078
19	T.CD4_Th2	4.90	Nominal	—	0.00	Other	1	2
20	T.CD4_cytotoxic	4.88	Nominal	1.00	0.22	Other	855	1,493
21	B.naive	3.86	Nominal	2.75e-07	1.64	Other	307	595
22	FIB.hepatic_stellate_cell	2.95	Nonsignificant	—	2.34	Other	64	252
23	THYMO.thymocyte	2.70	Nonsignificant	—	—	Other	163	495
24	NK.natural_killer_cell	2.67	Nonsignificant	—	—	Other	1,204	2,045
25	SKM.type_1_slow	2.59	Nonsignificant	0.22	1.38	Other	923	2,478
26	SKM.type_2_fast	2.52	Nonsignificant	0.22	1.24	Other	972	2,639
27	B.memory	2.52	Nonsignificant	1.00	0.38	Other	442	882
28	EC.venous	2.51	Nonsignificant	4.47e-38	1.41	Other	516	1,387
29	DC.cDC1	2.48	Nonsignificant	0.68	1.03	Other	55	112
30	MAC.LAM	2.20	Nonsignificant	0.02	1.15	Other	914	2,064
31	MAC.proliferating	2.17	Nonsignificant	1.00	0.89	Other	87	253
32	EPI.alveolar_type_2	2.16	Nonsignificant	1.60e-03	1.22	Other	813	1,853
33	EPI.cervical_suprabasal	1.99	Nonsignificant	—	1.61	Other	14	50
34	T.CD8_Tem	1.99	Nonsignificant	1.00	2.51e-03	Other	1,083	1,857
35	HEP.periportal_metabolic	1.89	Nonsignificant	3.79e-17	1.60	Other	1,750	4,427
36	FIB.barrier_secretory	1.83	Nonsignificant	0.08	1.76	Other	81	228
37	MONO.CD14	1.79	Nonsignificant	2.54e-44	1.91	Other	2,294	4,139
38	GRANU.MAST	1.51	Nonsignificant	0.20	1.61	Other	5	6
39	EPI.skin_interfollicular_spinous	1.39	Nonsignificant	0.77	1.12	Other	260	563
40	MAC.microglia_like	1.34	Nonsignificant	1.00	0.77	Other	124	179
41	DC.cDC2	1.32	Nonsignificant	0.64	1.11	Other	1,189	1,793
42	GRANU.neutrophil	1.30	Nonsignificant	0.90	0.32	Other	1,235	2,649
43	MESO.mesothelial_cell	1.23	Nonsignificant	—	—	Other	2	18
44	EPI.renal_distal_tubule	1.13	Nonsignificant	1.00	1.13	Other	133	361
45	HPC.haematopoietic_progenitor_cell	1.04	Nonsignificant	—	—	Other	211	370
46	ADIPO.adipocyte	0.95	Nonsignificant	—	—	Other	20	62
47	SCHWN.schwann_cell	0.90	Nonsignificant	—	—	Other	7	33
48	EPI.skin_sweat_duct_keratinocyte	0.82	Nonsignificant	1.00	1.03	Other	146	301
49	HEP.acute_phase	0.70	Nonsignificant	1.00	0.87	Other	1,441	3,641
50	EPI.ileal_enterocyte_absorptive	0.61	Nonsignificant	1.00	1.10	Other	118	338
51	MAC.MDM	0.57	Nonsignificant	1.00	0.91	Other	623	986
52	ASPC.adipose_stem_and_progenitor_cell	0.56	Nonsignificant	—	—	Other	324	930
53	FIB.neurolectin_mucosa	0.56	Nonsignificant	0.24	1.47	Other	133	394
54	MAC.resident_iron	0.53	Nonsignificant	1.00	0.73	Other	16	21
55	FIB.barrier_purinergic	0.53	Nonsignificant	—	0.75	Other	1	3
56	EPI.salivary_duct_ion_transport	0.53	Nonsignificant	1.00	1.02	Other	5	11
57	EPI.ileal_bile_transport	0.53	Nonsignificant	1.00	1.03	Other	61	93
58	GRNLSA.granulosa_cell	0.52	Nonsignificant	—	—	Other	257	0
59	ASTRO.astrocyte	0.51	Nonsignificant	—	—	Other	228	1,111
60	EPI.ectocervical_granular	0.49	Nonsignificant	—	1.05	Other	11	23
61	EPI.pancreatic_acinar	0.48	Nonsignificant	1.00	1.03	Other	429	1,475
62	EPI.lung_club_secretory	0.48	Nonsignificant	1.00	0.94	Other	5	14
63	EPI.ileal_enterocyte_crypt	0.38	Nonsignificant	1.00	0.99	Other	67	113
64	PC.IgG_systemic	0.33	Nonsignificant	0.18	1.27	Other	41	60
65	EPI.tracheal_submucosal_gland	0.31	Nonsignificant	—	0.65	Other	0	0
66	FIB.skin_neurosecretory	0.31	Nonsignificant	—	0.54	Other	0	0
67	FIB.adventitial	0.30	Nonsignificant	1.00	0.97	Other	268	1,447
68	MAC.resident_repair	0.28	Nonsignificant	1.00	0.74	Other	796	1,426
69	FIB.interstitial	0.27	Nonsignificant	1.00	0.98	Other	288	940
70	MG.microglia	0.26	Nonsignificant	—	—	Other	49	0
71	PC.IgA_muocsal	0.24	Nonsignificant	0.91	0.74	Other	18	31
72	HEP.canalicular_transport	0.24	Nonsignificant	1.00	0.09	Other	1,290	3,434
73	EPI.hepatic_ductular_cholangiocyte	0.24	Nonsignificant	1.00	0.86	Other	83	243
74	PLAT.platelet	0.24	Nonsignificant	—	0.00	Other	38	53
75	EC.capillary	0.21	Nonsignificant	1.00	0.69	Other	514	1,635
76	CHOND.chondrocyte	0.20	Nonsignificant	—	—	Other	519	730
77	EPI.esophageal_suprabasal	0.20	Nonsignificant	1.00	0.92	Other	158	404
78	FIB.reticular	0.20	Nonsignificant	1.00	0.71	Other	19	87
79	FIB.perivascular_interface	0.20	Nonsignificant	1.00	0.60	Other	0	0
80	MONO.CD16	0.19	Nonsignificant	1.00	0.04	Other	1,304	1,835
81	FIB.lung_alveolar	0.18	Nonsignificant	—	0.00	Other	6	15
82	EPI.lung_multiciliated	0.17	Nonsignificant	1.00	0.90	Other	16	49
83	MUSC.muscle_stem_cell	0.17	Nonsignificant	—	—	Other	4	18
84	FIB.transitioning	0.16	Nonsignificant	1.00	0.79	Other	172	497
85	EPI.esophageal_basal	0.15	Nonsignificant	1.00	0.87	Other	4	10
86	EPI.renal_principal_cell	0.15	Nonsignificant	1.00	0.85	Other	207	403
87	EC.arterial	0.13	Nonsignificant	1.00	0.68	Other	356	885
88	EPI.colonic_enteroendocrine	0.13	Nonsignificant	—	0.29	Other	1	1
89	FIB.suburothelial	0.10	Nonsignificant	1.00	0.43	Other	122	432
90	EPI.skin_keratinocyte_basal	0.10	Nonsignificant	—	0.49	Other	13	26
91	HEP.pericentral_lipoprotein	0.09	Nonsignificant	—	0.00	Other	0	0
92	SMC.smooth_muscle_cell	0.08	Nonsignificant	—	—	Other	20	101
93	EPI.renal_intercalated_cell_type_B	0.08	Nonsignificant	—	0.47	Other	6	7
94	FIB.tracheal_subepithelial	0.08	Nonsignificant	—	0.00	Other	0	0
95	MAC.kupffer	0.07	Nonsignificant	1.00	0.46	Other	189	530
96	EPI.renal_immature_ureteric_bud	0.06	Nonsignificant	1.00	0.78	Other	217	569
97	EPI.skin_keratinocyte_proliferating	0.05	Nonsignificant	1.00	0.80	Other	47	76
98	EPI.skin_appendage_keratinocyte	0.05	Nonsignificant	1.00	0.71	Other	87	222
99	EPI.colonic_tuft	0.05	Nonsignificant	—	0.33	Other	7	24
100	B.age_associated	0.05	Nonsignificant	1.00	0.00	Other	207	350
101	EPI.renal_thick_ascending_limb	0.05	Nonsignificant	1.00	0.80	Other	453	1,153
102	EPI.thymic_medullary	0.05	Nonsignificant	1.00	0.73	Other	26	133
103	EPI.salivary_myoepithelial	0.04	Nonsignificant	9.09e-04	1.29	Other	191	714
104	EPI.skin_hair_follicle_companion	0.04	Nonsignificant	—	0.33	Other	8	12
105	FIB.skin_sheath	0.04	Nonsignificant	1.00	0.08	Other	49	118
106	EC.liver_sinusoidal	0.04	Nonsignificant	1.00	0.73	Other	1,083	1,925
107	EPI.intrahepatic_cholangiocyte_defense	0.03	Nonsignificant	—	0.00	Other	8	13
108	EPI.ileal_goblet	0.03	Nonsignificant	1.00	1.06	Other	181	432
109	EPI.skin_keratinocyte_progenitor	0.03	Nonsignificant	—	0.26	Other	0	3
110	EPI.skin_hair_follicle_bulge	0.03	Nonsignificant	1.00	0.62	Other	51	178
111	EPI.intrahepatic_cholangiocyte_transport	0.03	Nonsignificant	—	0.00	Other	12	42
112	EPI.pancreatic_ductal_bicarbonate	0.03	Nonsignificant	1.00	0.91	Other	131	548
113	NEU.EXC_CT	0.02	Nonsignificant	0.75	1.10	Other	362	384
114	PERI.pericyte	0.02	Nonsignificant	—	—	Other	117	0
115	EPI.skin_follicular_keratinizing	0.02	Nonsignificant	1.00	0.61	Other	30	81
116	EPI.renal_intercalated_cell_type_A	0.01	Nonsignificant	1.00	0.66	Other	67	142
117	EPI.pancreatic_islet	0.01	Nonsignificant	1.00	0.63	Other	52	132
118	EPI.colonocyte	0.01	Nonsignificant	1.00	0.60	Other	294	815
119	EPI.salivary_intercalated_defense	0.01	Nonsignificant	1.00	0.78	Other	81	161
120	EC.lymphatic	9.18e-03	Nonsignificant	1.00	0.42	Other	630	998
121	EPI.pancreatic_ductal_perivascular	8.20e-03	Nonsignificant	1.00	0.63	Other	4	30
122	NEU.EXC_IT	7.06e-03	Nonsignificant	0.75	1.02	Other	411	192
123	EPI.skin_sebaceous_duct_luminal	6.57e-03	Nonsignificant	1.00	0.54	Other	100	249
124	EC.heart_remodeling	6.06e-03	Nonsignificant	1.00	0.97	Other	569	1,594
125	EPI.tracheal_suprabasal	5.97e-03	Nonsignificant	1.00	0.68	Other	29	56
126	EPI.alveolar_type_1	5.30e-03	Nonsignificant	1.00	0.50	Other	26	101
127	EPI.gastric_foveolar	5.00e-03	Nonsignificant	—	0.00	Other	0	0
128	FIB.skin_tenogenic	4.83e-03	Nonsignificant	—	0.00	Other	108	227
129	EPI.endocervical_secretory	4.82e-03	Nonsignificant	—	0.00	Other	0	0
130	MEL.melanocyte	3.06e-03	Nonsignificant	—	—	Other	79	242
131	NEU.INH_VIP	2.99e-03	Nonsignificant	1.00	0.98	Other	241	366
132	FIB.skin_papillary	2.87e-03	Nonsignificant	—	0.00	Other	0	0
133	EPI.pancreatic_ductal_mucinous	2.08e-03	Nonsignificant	1.00	0.67	Other	219	430
134	EPI.salivary_duct_excretory	1.81e-03	Nonsignificant	1.00	0.59	Other	85	180
135	DC.pDC	1.72e-03	Nonsignificant	1.00	0.05	Other	496	1,028
136	EPI.renal_proximal_tubule	1.58e-03	Nonsignificant	1.00	0.51	Other	525	806
137	EPI.pancreatic_ductal_progenitor	1.27e-03	Nonsignificant	1.00	0.38	Other	234	873
138	IPSC.induced_pluripotent_stem_cell	1.14e-03	Nonsignificant	—	—	Other	0	0
139	MAC.resident_cardiac	8.84e-04	Nonsignificant	1.00	0.05	Other	485	1,074
140	CM.cardiomyocyte	8.20e-04	Nonsignificant	—	—	Other	524	2,032
141	EPI.salivary_serous_acinar	8.08e-04	Nonsignificant	1.00	0.47	Other	233	531
142	OPC.oligodendrocyte_precursor_cell	7.05e-04	Nonsignificant	—	—	Other	413	1,269
143	OLG.oligodendrocyte	2.68e-04	Nonsignificant	—	—	Other	384	1,397
144	EPI.tracheal_basal	1.43e-04	Nonsignificant	1.00	0.24	Other	398	1,120
145	NEU.INH_LAMP5	1.31e-04	Nonsignificant	1.00	0.81	Other	263	532
146	NEU.INH_PVALB	6.87e-05	Nonsignificant	1.00	0.65	Other	193	183
147	EPI.bile_duct_cholangiocyte	4.87e-05	Nonsignificant	1.00	0.19	Other	37	60
148	EPI.salivary_mucous_acinar	4.40e-05	Nonsignificant	1.00	0.16	Other	639	1,189
149	NEU.EXC_SYT2	3.48e-05	Nonsignificant	—	0.00	Other	40	77
150	EPI.extrahepatic_cholangiocyte	2.78e-05	Nonsignificant	—	0.00	Other	37	71
151	EPI.thymic_cortical	1.79e-06	Nonsignificant	1.00	0.15	Other	442	824
152	NEU.EXC_NTNG1	6.07e-08	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	T.CD4_naive.activated_stress	42.45	Significant	7.20e-04	2.55	—	339	429
2	T.CD4_naive.homeostatic	33.66	Significant	0.19	1.44	—	215	108
3	T.CD4_naive.purinergic	33.57	Significant	0.21	1.65	—	49	1
4	T.CD4_naive.resist_bystander	31.79	Significant	0.51	1.36	—	40	25
5	T.CD4_naive.survival_neddylation	31.54	Significant	0.57	1.25	Relevant	26	38
6	T.CD4_naive.survival_mitoprot	31.13	Significant	0.71	1.11	—	13	7
7	T.CD4_naive.neddylation_mitoprot	30.89	Significant	0.71	1.08	—	93	56
8	T.CD4_naive.survival	30.88	Significant	0.52	1.31	Relevant	12	17
9	T.CD4_naive.mature_mitoprot	30.52	Significant	1.00	0.86	Specific	212	476
10	T.CD4_naive.neddylation	30.47	Significant	0.71	1.05	Specific	104	222
11	T.CD4_naive.mature	29.41	Significant	1.00	0.67	—	211	100
12	T.CD4_Tcm.synapse_dynamics	26.59	Significant	0.09	1.84	—	15	10
13	T.CD4_naive.proteostasis_mitoprot	25.24	Significant	1.00	0.41	Relevant	15	37
14	T.CD4_naive.proteostasis	25.17	Significant	1.00	0.34	—	14	9
15	T.CD8_naive.baseline	24.93	Significant	1.09e-03	2.05	—	142	2
16	T.CD4_Tcm.retro_ZNF117	24.82	Significant	0.28	1.46	Relevant	5	9
17	T.CD8_naive.lipid_synthesis	24.35	Significant	0.47	1.41	—	6	4
18	T.CD4_Tcm.secretory	24.24	Significant	0.22	1.56	—	20	11
19	T.CD8_naive.cytokine_dampened	23.74	Significant	0.47	1.33	—	71	4
20	T.CD4_Tcm.migratory_cilium	23.68	Significant	0.22	1.61	—	5	10
21	T.CD4_Tcm.baseline	23.62	Significant	0.41	1.25	—	61	31
22	T.CD8_naive.innate_like	23.38	Significant	0.81	0.75	—	10	1
23	T.CD8_naive.vesicle_secretory	22.98	Significant	0.81	0.97	—	42	0
24	T.CD4_Tcm.stress	22.87	Significant	0.22	1.57	Relevant	5	11
25	T.CD4_Trm.stress_adaptive	22.57	Significant	0.85	1.09	—	8	22
26	T.CD8_naive.mito_proteostasis	22.52	Significant	0.81	0.79	—	428	100
27	T.CD4_Tcm.RNA_control	22.37	Significant	0.37	1.32	—	96	4
28	T.CD4_Tcm.imprinted_splicing	22.05	Significant	0.57	1.13	Relevant	6	17
29	T.CD4_Tcm.DC_interact	21.75	Significant	0.37	1.30	—	72	32
30	T.CD8_naive.effector_transition	21.66	Significant	0.81	0.79	Relevant	35	62
31	T.CD4_naive.Treg_like	20.88	Significant	1.00	0.17	—	121	72
32	T.CD8_naive.nfkb_related	20.34	Significant	0.81	0.77	—	1	0
33	T.CD4_Tcm.Tfh_like	20.29	Significant	0.57	1.13	Relevant	102	214
34	T.CD4_Tcm.regulatory_poised	19.96	Significant	1.00	0.71	—	2	3
35	T.CD4_Tcm.crosstalk_myeloid	19.95	Significant	1.00	0.79	—	5	4
36	T.CD4_Trm.cytotoxic_effector	19.85	Significant	0.85	1.33	—	118	77
37	T.CD4_Trm.helper_like	19.03	Significant	0.85	0.70	Relevant	84	147
38	T.CD4_Trm.central_like	18.83	Significant	0.85	1.09	—	38	31
39	MAC.alveolar.capillary_interacting	18.69	Significant	0.16	1.88	Relevant	113	181
40	T.CD4_Th17.migratory	17.99	Significant	0.74	1.12	Relevant	13	23
41	T.CD8_naive.splicing_enriched	17.94	Significant	0.99	0.30	—	120	16
42	ILC2.quiescent	17.86	Significant	—	0.35	—	0	0
43	MAC.alveolar.scavenging_endocytic	17.38	Significant	—	0.31	Relevant	140	283
44	T.CD4_Th17.baseline	17.24	Significant	0.74	1.00	—	51	5
45	T.CD4_Tcm.effector_like	17.02	Significant	1.00	0.55	Relevant	293	533
46	ILC2.activated	16.75	Significant	—	6.94e-17	—	0	0
47	T.CD4_Trm.baseline	16.63	Significant	0.85	0.74	—	31	21
48	T.CD4_Tcm.APC_mimicry	16.60	Significant	1.00	0.37	—	54	43
49	T.CD4_naive.gut_prone	16.44	Significant	1.00	0.02	—	35	70
50	T.CD4_Tcm.tissue_homing	16.27	Significant	1.00	0.20	—	78	46
51	T.CD8_Tcm.helper_like	16.21	Significant	0.31	1.35	Relevant	81	159
52	MAC.alveolar.biosynthetic_sterol_heme	16.16	Significant	0.38	1.42	—	347	40
53	T.CD4_Trm.metal_stress	16.09	Significant	0.85	0.67	Relevant	34	58
54	T.CD4_Tcm.Th2_like	15.92	Significant	1.00	0.39	Relevant	23	55
55	MAC.alveolar.inflammatory	15.84	Significant	0.62	1.01	Relevant	208	312
56	T.CD8_Tcm.gut_homing	15.60	Significant	0.28	1.50	—	380	112
57	B.germinal_center.LZ_survival	15.53	Significant	—	1.47	—	0	0
58	T.CD4_Th17.cytotoxic	15.30	Significant	0.80	0.71	—	332	123
59	T.CD8_Tcm.baseline	14.99	Significant	0.78	1.02	—	90	89
60	T.CD4_Trm.activated	14.84	Significant	0.85	0.61	—	32	26
61	ILC2.migratory	14.77	Significant	—	0.00	—	0	0
62	T.CD4_Tem.long_term_memory	14.20	Significant	5.31e-04	1.83	Specific	314	587
63	T.CD4_Tfh.precursor_migratory	14.05	Significant	0.05	1.70	—	72	27
64	T.CD4_Tfh.effector_migratory	14.02	Significant	0.32	1.31	—	122	57
65	T.CD4_Treg.tissue_effector	13.70	Significant	0.16	1.51	—	16	13
66	T.MAIT.stress	13.62	Significant	—	1.14	—	0	0
67	MAC.alveolar.lipid_autophagy	13.45	Significant	—	0.00	Relevant	35	44
68	T.CD4_transitional.baseline	13.22	Significant	0.23	1.43	Relevant	59	97
69	MAC.alveolar.stress_metabolic	12.96	Significant	0.95	0.22	Relevant	116	148
70	T.CD4_transitional.tissue_enagement	11.67	Significant	0.27	1.44	Relevant	5	11
71	T.CD4_Treg.central_naive_like	10.92	Significant	0.37	1.19	—	333	45
72	B.germinal_center.LZ_memory_precursor	10.86	Significant	—	0.79	Relevant	0	0
73	T.CD8_transitional.early	9.96	Significant	1.68e-08	1.81	—	327	55
74	T.CD8_Tcm.effector_bias	9.70	Significant	1.00	0.31	Relevant	199	329
75	T.MAIT.quiescent	9.53	Significant	0.84	1.30	—	100	5
76	T.CD8_Trm.cytotoxic	9.38	Significant	0.22	1.40	—	165	85
77	T.CD8_Trm.homeostatic	9.35	Significant	0.45	1.23	—	42	5
78	T.CD4_Tem.transitional_CM	9.20	Significant	1.00	0.99	—	31	20
79	T.CD8_Trm.inflammatory	9.11	Significant	0.83	1.01	Relevant	124	176
80	T.MAIT.cytotoxic	9.10	Significant	0.84	1.03	—	52	15
81	T.gamma_delta.central_memory	9.00	Significant	3.08e-08	2.43	Specific	460	919
82	T.CD4_Treg.Tr1_like	8.91	Significant	—	0.00	—	8	8
83	T.CD4_Tem.inflammatory	8.58	Significant	1.00	0.65	—	28	6
84	B.germinal_center.LZ_selection	8.34	Significant	—	0.00	—	0	0
85	T.MAIT.migratory	8.28	Significant	0.84	0.95	—	10	1
86	B.germinal_center.DZ_S_phase	8.21	Significant	—	0.00	—	0	0
87	T.CD8_transitional.stress	8.18	Significant	—	0.49	—	24	34
88	NK.cytokine_tissue_resident	8.15	Significant	5.37e-04	2.18	Specific	74	82
89	NK.immature_bridge	7.92	Significant	1.10e-22	2.76	Specific	117	122
90	T.CD8_Trm.muscosal_Tc17	7.87	Significant	0.98	0.66	Relevant	19	38
91	T.CD4_transitional.APC_interacting	7.70	Significant	0.95	0.44	—	10	14
92	T.MAIT.early_activation	7.61	Significant	0.84	0.82	—	57	4
93	T.MAIT.MAPK_brake	7.49	Significant	0.84	0.69	Relevant	44	66
94	T.CD4_cytotoxic.precursor	7.43	Significant	0.06	1.84	—	156	67
95	T.MAIT.vesicle	7.38	Significant	0.84	0.55	Relevant	37	65
96	T.CD4_Tfh.suppression_exhaustion	7.35	Significant	1.00	0.51	—	0	2
97	T.CD4_transitional.primed_helper_effector	7.20	Significant	0.95	0.63	Relevant	19	43
98	T.CD8_transitional.Trm_primed	6.89	Significant	0.80	1.06	—	108	15
99	T.CD4_transitional.primed_cytotoxic	6.75	Significant	0.95	0.50	—	28	30
100	DC.mig.baseline	6.65	Significant	—	0.00	—	1	0
101	T.CD4_Treg.APC_interactive	6.60	Significant	0.98	0.43	—	118	28
102	B.germinal_center.DZ_M_phase	6.56	Significant	—	0.00	—	0	0
103	T.CD8_Trm.dendritic_recruiter	6.50	Significant	0.98	0.38	Relevant	47	85
104	EPI.skin_interfollicular_spinous.upper_lipid	6.47	Significant	—	1.42	Other	6	6
105	EC.venous.activated	6.05	Significant	1.27e-10	2.09	Specific	247	752
106	NK.cytokine_tissue_activation	5.96	Significant	3.06e-03	2.04	Specific	267	450
107	T.CD4_cytotoxic.baseline	5.56	Significant	0.74	1.06	Other	0	0
108	B.naive.purinergic	5.43	Nominal	4.20e-05	1.76	Other	384	820
109	DC.cDC1.homeostatic_inhibitory	5.31	Nominal	—	1.21	Other	0	0
110	T.CD4_Th2.precursor	5.25	Nominal	—	0.00	Other	0	0
111	T.CD4_cytotoxic.activated	5.23	Nominal	0.74	1.10	Other	3	1
112	T.CD4_cytotoxic.NK_adapted	5.22	Nominal	0.76	0.90	Other	82	33
113	T.CD4_Tem.cytotoxic_effector	4.97	Nominal	1.00	0.18	Other	225	398
114	MAC.proliferating.stress	4.75	Nominal	—	0.21	Other	87	136
115	T.gamma_delta.early_effector	4.58	Nominal	0.90	0.93	Other	89	0
116	THYMO.SP_CD4_naive	4.46	Nominal	0.09	1.54	Other	65	75
117	T.CD4_Th2.tissue_adapted	4.36	Nominal	—	0.00	Other	0	0
118	NK.cytokine_lung_immediate_early	4.29	Nominal	3.06e-03	1.99	Other	424	274
119	B.naive.activated	4.21	Nominal	1.00	1.06	Other	77	127
120	FIB.adventitial.activated_remodelling	4.01	Nominal	—	2.23	Other	141	319
121	THYMO.DP_early	3.96	Nominal	8.45e-06	1.98	Other	326	313
122	B.naive.remodeling	3.88	Nominal	1.00	0.78	Other	135	230
123	T.CD4_Tfh.canonical_GC_helper	3.85	Nominal	1.00	0.00	Other	1	2
124	EPI.alveolar_type_2.injury_primed	3.84	Nominal	4.15e-05	1.92	Other	434	245
125	FIB.hepatic_stellate_cell.inflammatory	3.73	Nominal	—	1.15	Other	0	0
126	B.naive.proteostasis	3.65	Nominal	1.00	0.77	Other	49	69
127	T.CD4_cytotoxic.terminal_effector	3.63	Nominal	1.00	0.00	Other	286	21
128	B.naive.receptor_recycle	3.54	Nominal	1.00	0.67	Other	51	0
129	THYMO.DP_early_stress	3.48	Nominal	—	0.62	Other	0	0
130	T.CD8_transitional.effector_primed	3.43	Nominal	1.00	0.35	Other	435	151
131	MAC.MDM.LAM_like	3.43	Nominal	0.53	1.27	Other	12	14
132	ASPC.signal_integrator	3.42	Nominal	—	2.43	Other	0	0
133	DC.cDC1.proliferative	3.36	Nominal	—	0.49	Other	0	0
134	B.naive.baseline	3.36	Nominal	1.00	0.69	Other	10	13
135	T.CD8_Tcm.NK_like	3.33	Nominal	1.00	0.00	Other	334	581
136	FIB.hepatic_stellate_cell.contractile	3.23	Nominal	—	0.32	Other	0	0
137	B.naive.antigen_presenting_ready	3.07	Nominal	1.00	0.69	Other	48	73
138	SKM.type_1_slow.glycolytic	3.02	Nominal	4.36e-03	2.16	Other	362	647
139	MAC.LAM.antimicrobial	3.00	Nonsignificant	0.47	1.17	Other	389	93
140	MAC.LAM.lipid_phagocytosis	2.98	Nonsignificant	0.47	1.33	Other	369	328
141	B.naive.metabolic	2.97	Nonsignificant	1.00	0.61	Other	50	79
142	DC.cDC2.pro_inflammatory	2.96	Nonsignificant	0.19	1.35	Other	3	5
143	T.gamma_delta.cytotoxic_effector	2.95	Nonsignificant	1.00	0.04	Other	349	109
144	SKM.type_1_slow.contractile	2.88	Nonsignificant	9.91e-04	2.37	Other	596	8
145	B.memory.baseline	2.81	Nonsignificant	9.71e-03	1.59	Other	472	99
146	MAC.LAM.anti_inflammatory	2.79	Nonsignificant	0.47	1.16	Other	86	132
147	EPI.renal_distal_tubule.immune_modulatory	2.78	Nonsignificant	—	1.16	Other	0	0
148	T.CD8_Tem.stress_adapted	2.75	Nonsignificant	0.01	1.56	Other	607	520
149	HPC.GMP_inflammatory	2.70	Nonsignificant	0.05	1.48	Other	20	10
150	THYMO.CD8aa_IELp	2.68	Nonsignificant	—	0.06	Other	1	7
151	SKM.type_2_fast.glycolytic_IIx_IIb	2.68	Nonsignificant	0.67	1.17	Other	565	1,482
152	HEP.periportal_metabolic.acute_phase_barrier	2.63	Nonsignificant	0.14	1.37	Other	533	138
153	B.memory.migratory	2.60	Nonsignificant	0.98	0.78	Other	123	208
154	THYMO.SP_CD8_naive	2.58	Nonsignificant	1.00	0.87	Other	297	177
155	MAC.resident_repair.lipid_phagocytic	2.43	Nonsignificant	0.30	1.30	Other	228	604
156	SKM.type_2_fast.oxidative_IIa	2.43	Nonsignificant	0.73	0.70	Other	946	56
157	B.naive.restrained	2.42	Nonsignificant	1.00	0.31	Other	183	353
158	NK.adaptive_adipose_stress	2.41	Nonsignificant	1.00	1.14	Other	374	39
159	NK.adaptive_axis_baseline	2.41	Nonsignificant	1.00	0.77	Other	1,008	153
160	NK.adaptive_biosynthetic_primed	2.34	Nonsignificant	1.00	0.67	Other	244	405
161	EPI.alveolar_type_2.baseline_surfactant	2.34	Nonsignificant	0.86	0.96	Other	64	9
162	FIB.hepatic_stellate_cell.fibrogenic	2.32	Nonsignificant	—	0.00	Other	0	0
163	SCHWN.reactive_inflammatory	2.31	Nonsignificant	—	1.14	Other	0	0
164	T.CD8_Tem.baseline	2.31	Nonsignificant	0.18	1.32	Other	458	356
165	MONO.CD14.remodeling	2.31	Nonsignificant	0.36	1.15	Other	2,373	295
166	EPI.cervical_suprabasal.secretory_vesicle	2.29	Nonsignificant	—	0.00	Other	0	0
167	EPI.renal_distal_tubule.ciliated_remodelling	2.28	Nonsignificant	—	1.04	Other	0	0
168	MAC.LAM.perivascular_angiocrine	2.27	Nonsignificant	—	0.25	Other	53	138
169	THYMO.SP_CD8_transitional	2.27	Nonsignificant	1.00	0.71	Other	32	75
170	EC.venous.adipose_lipid	2.22	Nonsignificant	1.00	0.78	Other	254	476
171	HEP.periportal_metabolic.stress_checkpoint	2.22	Nonsignificant	0.12	1.44	Other	234	786
172	B.memory.activated	2.22	Nonsignificant	0.98	0.63	Other	105	29
173	NK.adaptive_terminal_cytotoxic	2.20	Nonsignificant	1.00	0.66	Other	485	802
174	MAC.microglia_like.inflammatory_chemokine	2.20	Nonsignificant	—	0.77	Other	20	32
175	T.CD8_transitional.APC_like	2.15	Nonsignificant	1.00	0.00	Other	205	62
176	FIB.barrier_secretory.homeostasis	2.15	Nonsignificant	—	0.00	Other	0	0
177	NK.cytokine_biosynthetic_primed	2.15	Nonsignificant	1.00	0.76	Other	360	21
178	NK.cytokine_vascular_patrolling	2.14	Nonsignificant	1.00	0.55	Other	863	94
179	HEP.periportal_metabolic.canonical_urea_cycle	2.13	Nonsignificant	1.07e-04	1.78	Other	1,464	269
180	NK.adaptive_HLAE_tuned	2.11	Nonsignificant	1.00	0.51	Other	1,124	189
181	NK.cytokine_axis_baseline	2.07	Nonsignificant	1.00	0.56	Other	1,172	116
182	EC.venous.baseline	2.04	Nonsignificant	1.00	0.62	Other	346	807
183	EC.venous.remodeling_stalk	2.00	Nonsignificant	1.00	0.80	Other	559	566
184	HEP.periportal_metabolic.stress_chaperone	1.93	Nonsignificant	—	0.26	Other	66	128
185	SKM.type_1_slow.oxidative	1.93	Nonsignificant	1.00	0.09	Other	802	251
186	THYMO.SP_CD8_naive_stress	1.92	Nonsignificant	1.00	0.54	Other	1	1
187	HEP.periportal_metabolic.inflammatory_activated	1.90	Nonsignificant	0.72	1.00	Other	712	1,610
188	GRANU.MAST.activated_acute	1.90	Nonsignificant	—	0.66	Other	0	0
189	HEP.acute_phase.inflammatory	1.86	Nonsignificant	1.50e-05	1.84	Other	382	649
190	MONO.CD14.baseline	1.83	Nonsignificant	0.48	1.08	Other	2,268	76
191	ADIPO.inflammatory	1.83	Nonsignificant	—	0.97	Other	0	0
192	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.82	Nonsignificant	—	1.36	Other	0	0
193	MAC.LAM.inflammatory_APC	1.81	Nonsignificant	0.88	0.80	Other	872	165
194	DC.cDC2.migratory	1.81	Nonsignificant	0.08	1.43	Other	185	39
195	MONO.CD14.repair_M2_like	1.79	Nonsignificant	1.00	0.99	Other	550	1,495
196	MONO.CD14.inflammatory	1.78	Nonsignificant	1.00	0.89	Other	92	134
197	NK.cytokine_quiescent	1.77	Nonsignificant	1.00	0.18	Other	623	1,062
198	NK.cytokine_repair_primed	1.76	Nonsignificant	1.00	0.15	Other	266	11
199	GRANU.MAST.activated_repair	1.72	Nonsignificant	—	0.31	Other	0	1
200	HEP.periportal_metabolic.xenobiotic_detox	1.72	Nonsignificant	0.35	1.18	Other	1,440	139
201	MESO.activated_migratory	1.72	Nonsignificant	—	0.86	Other	0	0
202	DC.cDC2.adhesion_signaling	1.71	Nonsignificant	0.19	1.29	Other	35	9
203	T.CD8_Tem.motility_primed	1.70	Nonsignificant	1.00	0.81	Other	269	4
204	EPI.cervical_suprabasal.inflammatory_repair	1.69	Nonsignificant	—	0.00	Other	0	0
205	NK.adaptive_classII_inhibitory	1.68	Nonsignificant	1.00	0.31	Other	880	154
206	DC.cDC2.lipid_metabolic	1.67	Nonsignificant	—	0.42	Other	0	0
207	NK.adaptive_immature_precursor	1.63	Nonsignificant	1.00	0.21	Other	358	111
208	DC.cDC1.cross_presenting	1.63	Nonsignificant	—	0.00	Other	0	0
209	HPC.MPP_IEG	1.61	Nonsignificant	0.38	1.26	Other	45	46
210	HPC.MPP_activated	1.59	Nonsignificant	—	0.83	Other	0	0
211	T.CD8_Tem.early_helper_like	1.59	Nonsignificant	1.00	0.64	Other	445	755
212	DC.cDC1.activated	1.57	Nonsignificant	—	0.00	Other	0	0
213	GRANU.neutrophil.tissue_patrolling	1.56	Nonsignificant	—	0.52	Other	0	0
214	EPI.skin_interfollicular_spinous.stress_UPR	1.55	Nonsignificant	—	0.57	Other	0	0
215	EC.venous.quiescent_homeostatic	1.55	Nonsignificant	1.00	0.52	Other	456	360
216	B.memory.preactivated	1.50	Nonsignificant	0.98	0.53	Other	173	174
217	HEP.periportal_metabolic.urea_onecarbon_secretory	1.49	Nonsignificant	0.87	0.87	Other	1,332	3,053
218	B.memory.pDC_imprint	1.45	Nonsignificant	0.98	0.32	Other	157	103
219	ADIPO.thermogenic	1.44	Nonsignificant	—	0.44	Other	0	0
220	EC.capillary.angiogenic_tip	1.41	Nonsignificant	0.04	1.50	Other	186	218
221	FIB.barrier_secretory.remodeling	1.40	Nonsignificant	—	0.00	Other	0	0
222	EPI.skin_interfollicular_spinous.baseline	1.39	Nonsignificant	0.93	1.00	Other	35	3
223	EPI.skin_sweat_duct_keratinocyte.barrier	1.38	Nonsignificant	—	0.76	Other	0	0
224	ASTRO.stress_mito	1.37	Nonsignificant	0.35	1.26	Other	47	110
225	MESO.secretory_structural	1.33	Nonsignificant	—	0.00	Other	0	0
226	MAC.LAM.lipid_opsonization	1.31	Nonsignificant	0.88	0.63	Other	45	14
227	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.30	Nonsignificant	—	0.46	Other	0	0
228	T.CD8_Tem.signaling_turnover	1.29	Nonsignificant	1.00	0.67	Other	425	683
229	DC.cDC2.antiviral	1.28	Nonsignificant	0.70	1.02	Other	100	37
230	ASPC.inflammatory	1.27	Nonsignificant	2.01e-03	2.05	Other	21	61
231	GRANU.neutrophil.antiviral_endotoxin	1.25	Nonsignificant	—	0.00	Other	0	0
232	ASPC.mesothelial_like	1.25	Nonsignificant	0.09	1.74	Other	143	486
233	T.CD8_Tem.TEMRA	1.21	Nonsignificant	1.00	0.37	Other	920	1,088
234	MESO.baseline	1.19	Nonsignificant	0.80	0.80	Other	0	6
235	MAC.resident_iron.redox_metabolic	1.17	Nonsignificant	0.03	1.56	Other	4	4
236	MESO.activated_stress	1.17	Nonsignificant	—	0.00	Other	0	0
237	THYMO.proliferative_G2M	1.16	Nonsignificant	—	0.00	Other	164	413
238	ASTRO.homeostatic	1.14	Nonsignificant	0.01	1.38	Other	200	431
239	GRANU.neutrophil.primed_degranulation	1.14	Nonsignificant	—	0.00	Other	0	0
240	EPI.skin_interfollicular_spinous.early_differentiation	1.11	Nonsignificant	0.93	0.87	Other	89	19
241	EPI.skin_interfollicular_spinous.inflammatory	1.09	Nonsignificant	—	0.00	Other	0	0
242	MONO.CD14.platelet_bound	1.03	Nonsignificant	1.00	0.76	Other	964	176
243	THYMO.DN_preTCR	1.00	Nonsignificant	1.00	0.26	Other	41	71
244	EPI.ectocervical_granular.immune_interact	0.99	Nonsignificant	—	1.15	Other	0	0
245	HEP.acute_phase.complement_antiviral	0.98	Nonsignificant	0.47	1.18	Other	377	751
246	HEP.periportal_metabolic.apolipoprotein_secretory	0.98	Nonsignificant	0.96	0.40	Other	43	110
247	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.96	Nonsignificant	—	1.51	Other	10	20
248	MAC.resident_iron.stress_tolerogenic	0.96	Nonsignificant	—	0.91	Other	0	0
249	MAC.proliferating.DNA_replication	0.95	Nonsignificant	0.87	0.63	Other	3	6
250	GRANU.MAST.resting_granule	0.95	Nonsignificant	—	0.00	Other	0	0
251	EPI.renal_distal_tubule.stress	0.92	Nonsignificant	—	0.00	Other	0	0
252	ASPC.remodeling	0.92	Nonsignificant	3.81e-03	1.86	Other	106	354
253	SCHWN.translation_boost	0.91	Nonsignificant	—	0.76	Other	8	1
254	FIB.barrier_purinergic.stress_GF_binding	0.89	Nonsignificant	—	0.97	Other	0	0
255	EPI.skin_sweat_duct_keratinocyte.repair	0.89	Nonsignificant	—	0.20	Other	0	0
256	EPI.pancreatic_acinar.adhesion_remodeling	0.88	Nonsignificant	0.21	1.39	Other	210	784
257	MAC.microglia_like.phagocytic_redox	0.88	Nonsignificant	—	0.00	Other	0	0
258	ASPC.niche_keeping_progenitor	0.86	Nonsignificant	3.81e-03	1.76	Other	52	219
259	EPI.ectocervical_granular.secretory_apocrine	0.85	Nonsignificant	—	0.32	Other	0	0
260	MESO.antiviral	0.85	Nonsignificant	—	0.00	Other	3	8
261	DC.cDC1.baseline	0.84	Nonsignificant	—	0.00	Other	0	0
262	EPI.lung_club_secretory.inflammatory	0.83	Nonsignificant	—	0.79	Other	0	0
263	PC.IgG_systemic.stress	0.83	Nonsignificant	—	1.21	Other	1	5
264	HPC.GMP_granulocytic	0.82	Nonsignificant	—	0.19	Other	3	3
265	EPI.alveolar_type_2.stress_response	0.81	Nonsignificant	1.00	0.00	Other	675	1,562
266	DC.cDC2.proliferative	0.80	Nonsignificant	—	0.00	Other	39	71
267	MONO.CD14.cord_tolerance	0.79	Nonsignificant	1.00	0.45	Other	864	753
268	EPI.ileal_enterocyte_absorptive.brush_border	0.76	Nonsignificant	4.05e-05	2.88	Other	580	1,717
269	HEP.acute_phase.baseline	0.70	Nonsignificant	0.78	0.98	Other	946	19
270	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.70	Nonsignificant	—	0.00	Other	0	0
271	GRNLSA.proliferative_migratory	0.69	Nonsignificant	0.13	1.57	Other	248	292
272	EPI.ileal_enterocyte_crypt.villus_transition	0.68	Nonsignificant	—	1.22	Other	7	10
273	MONO.CD14.APC_like	0.68	Nonsignificant	1.00	0.40	Other	1,686	2,493
274	ASPC.activated	0.67	Nonsignificant	0.16	1.36	Other	164	162
275	ASPC.proliferative	0.67	Nonsignificant	0.34	1.34	Other	33	85
276	GRNLSA.cholesterol_mevalonate	0.66	Nonsignificant	0.13	1.60	Other	9	4
277	EPI.renal_principal_cell.inflammatory	0.65	Nonsignificant	0.13	1.44	Other	74	157
278	HEP.acute_phase.stress_secretory	0.64	Nonsignificant	0.78	0.90	Other	26	3
279	ASTRO.immature_lipid	0.63	Nonsignificant	1.00	0.85	Other	23	113
280	FIB.neurolectin_mucosa.axon_responsive	0.62	Nonsignificant	0.69	1.19	Other	10	10
281	HEP.acute_phase.proliferative	0.61	Nonsignificant	—	0.21	Other	4	6
282	ADIPO.hypoxia_remodelling	0.61	Nonsignificant	—	0.00	Other	29	105
283	FIB.adventitial.inflammatory_activated	0.60	Nonsignificant	0.05	1.47	Other	100	473
284	GRNLSA.lipid_hypoxia	0.60	Nonsignificant	0.41	1.21	Other	28	0
285	EPI.pancreatic_acinar.metabolic_onecarbon	0.60	Nonsignificant	0.15	1.37	Other	287	328
286	FIB.neurolectin_mucosa.remodeling_repair	0.59	Nonsignificant	—	0.34	Other	4	2
287	ASTRO.A2_reactive	0.59	Nonsignificant	1.00	0.96	Other	10	37
288	EPI.ileal_bile_transport.absorptive_xenobiotic	0.58	Nonsignificant	0.05	1.93	Other	11	12
289	DC.cDC2.monocyte_like	0.58	Nonsignificant	1.00	0.44	Other	1,285	791
290	MAC.resident_iron.heme_catabolism	0.56	Nonsignificant	0.96	0.91	Other	30	51
291	EPI.salivary_myoepithelial.contractile_repair	0.56	Nonsignificant	—	1.74	Other	3	9
292	ASPC.preadipocyte_lipid_primed	0.56	Nonsignificant	0.50	1.05	Other	331	129
293	FIB.neurolectin_mucosa.inflammatory	0.55	Nonsignificant	0.85	0.53	Other	52	110
294	PLAT.megakaryocytic	0.55	Nonsignificant	—	0.97	Other	0	0
295	EPI.pancreatic_acinar.baseline	0.55	Nonsignificant	0.29	1.21	Other	274	163
296	GRNLSA.EMT_insulin_signaling	0.54	Nonsignificant	0.41	1.24	Other	47	84
297	ASPC.adipocyte_capillary_interface	0.54	Nonsignificant	0.49	1.16	Other	21	54
298	EPI.salivary_duct_ion_transport.baseline	0.53	Nonsignificant	—	—	Other	0	0
299	ADIPO.immature	0.52	Nonsignificant	—	0.00	Other	24	40
300	ASTRO.synaptic_interaction	0.52	Nonsignificant	1.00	0.89	Other	76	334
301	GRNLSA.stress_metabolic	0.50	Nonsignificant	—	0.03	Other	1	2
302	DC.cDC2.tolerogenic_regulatory	0.49	Nonsignificant	1.00	0.42	Other	44	4
303	EPI.tracheal_submucosal_gland.acinar_serous	0.49	Nonsignificant	—	0.73	Other	0	0
304	ASPC.baseline	0.48	Nonsignificant	1.00	0.54	Other	363	170
305	EPI.skin_interfollicular_spinous.stress_oxidative	0.48	Nonsignificant	—	0.00	Other	0	0
306	EPI.ileal_enterocyte_absorptive.villus_tip	0.47	Nonsignificant	1.00	0.00	Other	4	3
307	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.46	Nonsignificant	—	1.16	Other	0	0
308	EC.capillary.postcap_venule	0.45	Nonsignificant	0.24	1.30	Other	355	261
309	EPI.ileal_enterocyte_crypt.proliferative_S	0.45	Nonsignificant	0.67	1.11	Other	4	2
310	FIB.neurolectin_mucosa.nerve_interface	0.44	Nonsignificant	—	0.00	Other	4	0
311	GRNLSA.p53_damage	0.43	Nonsignificant	—	0.00	Other	13	10
312	PC.IgG_systemic.interacting	0.43	Nonsignificant	0.80	1.00	Other	0	0
313	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.43	Nonsignificant	—	0.00	Other	0	0
314	EPI.ectocervical_granular.inflammatory	0.42	Nonsignificant	—	0.00	Other	0	0
315	SCHWN.axon_contact_cardiac	0.42	Nonsignificant	1.00	0.00	Other	18	63
316	FIB.adventitial.adhesion_lipid	0.42	Nonsignificant	0.87	1.18	Other	58	209
317	EPI.ileal_enterocyte_crypt.bile_transport	0.41	Nonsignificant	0.67	0.95	Other	2	0
318	HPC.LMPP	0.41	Nonsignificant	1.00	0.53	Other	65	31
319	EC.arterial.inflammatory	0.41	Nonsignificant	0.03	1.30	Other	63	50
320	EPI.lung_club_secretory.canonical_surfactant	0.40	Nonsignificant	—	0.10	Other	74	104
321	FIB.interstitial.mesenchymal_APC	0.39	Nonsignificant	2.58e-03	1.76	Other	81	33
322	EPI.lung_club_secretory.ciliogenesis_primed	0.39	Nonsignificant	—	0.00	Other	0	0
323	GRNLSA.secretory_remodeling	0.39	Nonsignificant	0.97	0.30	Other	90	25
324	EPI.ileal_enterocyte_crypt.baseline	0.39	Nonsignificant	0.67	0.87	Other	11	6
325	EPI.lung_club_secretory.ciliogenesis_axoneme	0.39	Nonsignificant	—	0.00	Other	0	0
326	EPI.ileal_bile_transport.detox_transcytosis	0.38	Nonsignificant	—	0.00	Other	0	1
327	ASPC.stem_like_progenitor	0.38	Nonsignificant	1.00	0.32	Other	300	842
328	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.37	Nonsignificant	—	0.00	Other	43	26
329	CHOND.remodeling	0.37	Nonsignificant	—	0.83	Other	5	0
330	HEP.canalicular_transport.inflammatory	0.37	Nonsignificant	3.38e-05	1.42	Other	1,335	194
331	EPI.colonic_enteroendocrine.Lcell_peptide	0.36	Nonsignificant	—	0.97	Other	0	0
332	EPI.pancreatic_acinar.inflammatory_regenerative	0.35	Nonsignificant	0.78	0.90	Other	25	113
333	GRNLSA.chemokine_mechanosensory	0.35	Nonsignificant	0.97	0.40	Other	1	0
334	MAC.resident_iron.APC_iron_sensing	0.34	Nonsignificant	0.98	0.55	Other	211	114
335	FIB.interstitial.immune_interact	0.33	Nonsignificant	0.59	1.21	Other	12	1
336	EPI.ileal_goblet.immature	0.32	Nonsignificant	—	0.89	Other	0	0
337	PC.IgG_systemic.secretory	0.32	Nonsignificant	0.80	1.14	Other	0	0
338	FIB.reticular.stress_metallothionein	0.32	Nonsignificant	—	0.15	Other	3	32
339	MONO.CD16.hepatic_mac_like	0.32	Nonsignificant	0.12	1.37	Other	803	117
340	EC.capillary.activated	0.31	Nonsignificant	0.47	1.31	Other	2	5
341	FIB.skin_neurosecretory.baseline	0.31	Nonsignificant	—	0.00	Other	0	0
342	MUSC.activated_migratory	0.31	Nonsignificant	0.15	1.60	Other	6	7
343	FIB.lung_alveolar.stress_interacting	0.31	Nonsignificant	—	0.97	Other	0	0
344	MG.phagocytic_APC	0.31	Nonsignificant	0.03	1.88	Other	25	8
345	PC.IgA_muocsal.plasmablast	0.30	Nonsignificant	0.52	1.10	Other	5	4
346	MONO.CD16.platelet_bound	0.30	Nonsignificant	0.33	1.29	Other	372	508
347	ASPC.secretory	0.30	Nonsignificant	1.00	0.01	Other	76	5
348	HPC.CLP_B_primed	0.29	Nonsignificant	—	0.00	Other	0	0
349	FIB.interstitial.mesenchymal_regulator	0.27	Nonsignificant	0.85	1.05	Other	4	4
350	MAC.kupffer.monocyte_like	0.27	Nonsignificant	—	1.29	Other	0	0
351	PC.IgA_muocsal.activated	0.27	Nonsignificant	0.52	1.18	Other	17	8
352	EPI.renal_distal_tubule.repair	0.26	Nonsignificant	—	0.00	Other	34	102
353	EPI.pancreatic_acinar.stress	0.26	Nonsignificant	0.50	1.07	Other	28	28
354	MAC.resident_repair.antigen_presenting	0.26	Nonsignificant	0.76	1.04	Other	244	113
355	FIB.interstitial.stress_secretory	0.26	Nonsignificant	1.00	0.76	Other	92	56
356	EPI.lung_multiciliated.stress	0.25	Nonsignificant	—	0.77	Other	67	165
357	MAC.microglia_like.patrolling_adhesive	0.25	Nonsignificant	—	0.00	Other	0	0
358	EC.liver_sinusoidal.inflammatory	0.25	Nonsignificant	—	0.64	Other	223	154
359	CHOND.articular_collagen	0.25	Nonsignificant	0.46	1.12	Other	551	266
360	MG.baseline	0.24	Nonsignificant	0.87	0.76	Other	16	5
361	FIB.barrier_purinergic.lipid_secretory	0.24	Nonsignificant	—	0.00	Other	0	0
362	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.24	Nonsignificant	—	0.20	Other	5	3
363	CHOND.activated_fibro_like	0.24	Nonsignificant	0.46	1.08	Other	531	188
364	ASTRO.hypoxia_angiogenic	0.24	Nonsignificant	1.00	0.75	Other	5	18
365	FIB.adventitial.baseline	0.24	Nonsignificant	1.00	0.85	Other	157	278
366	FIB.suburothelial.inflammatory_prostanoid	0.24	Nonsignificant	—	1.16	Other	0	0
367	MAC.resident_repair.stress_iron	0.23	Nonsignificant	0.76	1.18	Other	48	97
368	PC.IgA_muocsal.baseline	0.23	Nonsignificant	0.71	0.91	Other	3	5
369	THYMO.proliferative_S	0.23	Nonsignificant	1.00	0.00	Other	163	418
370	MAC.MDM.APC_dendritic	0.23	Nonsignificant	0.75	1.06	Other	48	15
371	EPI.esophageal_suprabasal.differentiating_keratin	0.23	Nonsignificant	0.05	1.69	Other	131	61
372	FIB.reticular.immune_interface	0.23	Nonsignificant	—	0.56	Other	1	6
373	MONO.CD16.inflammatory	0.22	Nonsignificant	0.02	1.39	Other	1,640	168
374	FIB.perivascular_interface.vasomotor_tone	0.22	Nonsignificant	—	0.36	Other	0	0
375	EPI.skin_interfollicular_spinous.transition_basal	0.22	Nonsignificant	1.00	0.00	Other	100	127
376	PC.IgA_muocsal.migratory	0.22	Nonsignificant	0.52	1.05	Other	4	1
377	EPI.skin_interfollicular_spinous.proliferative	0.21	Nonsignificant	—	0.00	Other	0	0
378	MAC.MDM.complement_resolving	0.21	Nonsignificant	0.76	0.89	Other	440	860
379	FIB.interstitial.remodeling	0.21	Nonsignificant	1.00	0.64	Other	31	9
380	FIB.transitioning.motility_remodelling	0.21	Nonsignificant	—	0.17	Other	0	0
381	EPI.skin_keratinocyte_basal.spinous_transition	0.21	Nonsignificant	—	0.97	Other	0	0
382	MG.expanding	0.21	Nonsignificant	0.87	0.56	Other	2	1
383	FIB.interstitial.lipid_matrix	0.21	Nonsignificant	1.00	0.39	Other	258	191
384	HEP.canalicular_transport.injury_stress	0.20	Nonsignificant	1.00	0.77	Other	289	24
385	FIB.transitioning.matrix_stress	0.20	Nonsignificant	—	0.55	Other	47	138
386	FIB.perivascular_interface.lipid_shuttle	0.19	Nonsignificant	—	0.05	Other	51	170
387	HEP.canalicular_transport.pericentral_like_hypoxia	0.19	Nonsignificant	1.00	0.90	Other	326	8
388	EC.capillary.stress	0.19	Nonsignificant	1.00	1.01	Other	44	36
389	EC.arterial.elastic	0.19	Nonsignificant	0.73	0.99	Other	22	45
390	MUSC.quiescent_reservoir	0.19	Nonsignificant	0.88	1.09	Other	2	8
391	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.19	Nonsignificant	—	0.00	Other	19	54
392	EPI.hepatic_ductular_cholangiocyte.stress	0.19	Nonsignificant	—	0.08	Other	0	0
393	EPI.esophageal_suprabasal.basal_transitional	0.18	Nonsignificant	0.24	1.32	Other	44	67
394	EPI.renal_thick_ascending_limb.barrier_repair	0.18	Nonsignificant	0.25	1.16	Other	141	284
395	FIB.perivascular_interface.vascular_BM_remodelling	0.18	Nonsignificant	—	0.00	Other	0	0
396	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.18	Nonsignificant	0.57	1.31	Other	14	32
397	MONO.CD16.baseline	0.17	Nonsignificant	0.57	1.04	Other	50	1
398	EPI.esophageal_basal.junctional_barrier	0.17	Nonsignificant	—	0.69	Other	0	0
399	HEP.acute_phase.complement_metabolic	0.17	Nonsignificant	1.00	0.02	Other	1,423	3,464
400	HEP.canalicular_transport.baseline	0.17	Nonsignificant	1.00	0.94	Other	199	477
401	FIB.reticular.stromal_niche	0.16	Nonsignificant	0.84	0.56	Other	0	0
402	FIB.adventitial.mechano_chemo_sensing	0.15	Nonsignificant	1.00	0.53	Other	135	524
403	SMC.contractile	0.15	Nonsignificant	1.63e-03	1.42	Other	80	588
404	FIB.suburothelial.contractile_myofibroblast	0.15	Nonsignificant	—	0.59	Other	9	0
405	EPI.esophageal_basal.activated_progenitor	0.15	Nonsignificant	0.64	0.85	Other	1	0
406	FIB.adventitial.mito_secretory	0.14	Nonsignificant	1.00	0.75	Other	21	7
407	EC.arterial.metabolic	0.13	Nonsignificant	0.73	0.99	Other	195	159
408	FIB.adventitial.PI16_matrix	0.13	Nonsignificant	1.00	0.43	Other	70	90
409	EC.arterial.arteriole_interface	0.13	Nonsignificant	0.73	1.02	Other	31	12
410	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.13	Nonsignificant	—	0.00	Other	6	9
411	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.13	Nonsignificant	0.23	1.27	Other	7	16
412	EC.arterial.homeostatic	0.13	Nonsignificant	0.73	0.97	Other	24	3
413	MUSC.baseline	0.13	Nonsignificant	0.90	0.64	Other	0	0
414	FIB.transitioning.ISG_primed_interface	0.13	Nonsignificant	—	0.00	Other	17	80
415	EPI.tracheal_submucosal_gland.ductal_luminal	0.13	Nonsignificant	—	0.00	Other	0	0
416	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.13	Nonsignificant	—	1.24	Other	29	88
417	MONO.CD16.patrolling	0.12	Nonsignificant	0.91	0.79	Other	797	216
418	EC.capillary.migratory	0.12	Nonsignificant	1.00	0.78	Other	181	509
419	FIB.suburothelial.homeostasis_matrix	0.12	Nonsignificant	1.00	0.90	Other	258	921
420	EPI.lung_multiciliated.baseline	0.12	Nonsignificant	—	0.00	Other	0	7
421	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.12	Nonsignificant	—	1.37	Other	0	0
422	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.11	Nonsignificant	—	0.87	Other	135	290
423	EPI.esophageal_suprabasal.proliferative_S	0.11	Nonsignificant	—	0.00	Other	26	41
424	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.11	Nonsignificant	—	0.00	Other	0	0
425	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.11	Nonsignificant	—	1.15	Other	0	0
426	EC.heart_remodeling.activated_acute	0.11	Nonsignificant	0.25	1.37	Other	102	186
427	EC.lymphatic.valve	0.11	Nonsignificant	—	1.70	Other	0	0
428	MAC.MDM.inflammatory_phagocytic	0.10	Nonsignificant	0.76	0.87	Other	199	52
429	FIB.transitioning.secretory_procollagen	0.10	Nonsignificant	—	0.00	Other	0	0
430	FIB.reticular.ECM_builder	0.10	Nonsignificant	—	0.00	Other	0	0
431	EPI.renal_principal_cell.activated_acute	0.10	Nonsignificant	0.99	0.92	Other	29	59
432	NEU.EXC_CT.Ca2_sensor	0.10	Nonsignificant	—	1.44	Other	0	0
433	EC.arterial.angiogenic_tip	0.10	Nonsignificant	—	0.00	Other	30	37
434	HEP.acute_phase.hypoxia_lipid	0.10	Nonsignificant	—	0.00	Other	0	0
435	EPI.esophageal_suprabasal.proliferative_G2M	0.10	Nonsignificant	—	0.00	Other	0	0
436	EPI.skin_keratinocyte_basal.transit_amplifying	0.10	Nonsignificant	—	0.00	Other	0	0
437	FIB.adventitial.complement_angiocrine	0.10	Nonsignificant	1.00	0.13	Other	153	684
438	ASTRO.stress_acute	0.10	Nonsignificant	1.00	0.69	Other	60	56
439	EPI.ectocervical_granular.proliferative_basal	0.09	Nonsignificant	—	0.00	Other	0	0
440	HEP.pericentral_lipoprotein.UPR_redox	0.09	Nonsignificant	—	0.67	Other	0	0
441	EC.arterial.mito_contact	0.09	Nonsignificant	0.73	1.00	Other	14	5
442	EPI.colonic_tuft.homeostatic	0.09	Nonsignificant	—	0.73	Other	0	0
443	HEP.canalicular_transport.secretory_ERAD_UPR	0.09	Nonsignificant	1.00	0.62	Other	232	28
444	MUSC.early_activation	0.08	Nonsignificant	0.90	0.43	Other	4	32
445	EC.capillary.baseline	0.08	Nonsignificant	1.00	0.61	Other	246	560
446	HEP.canalicular_transport.ductular_like_transition	0.08	Nonsignificant	1.00	0.42	Other	400	87
447	EC.capillary.inflammatory	0.08	Nonsignificant	1.00	0.51	Other	27	51
448	EPI.renal_intercalated_cell_type_B.baseline	0.08	Nonsignificant	—	0.00	Other	3	1
449	HEP.pericentral_lipoprotein.ApoB_coagulation	0.08	Nonsignificant	—	0.00	Other	0	0
450	FIB.lung_alveolar.mito_secretory	0.08	Nonsignificant	—	0.00	Other	0	0
451	FIB.tracheal_subepithelial.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
452	B.age_associated.migratory	0.08	Nonsignificant	0.20	1.20	Other	2	2
453	EPI.esophageal_suprabasal.proliferative_exit	0.08	Nonsignificant	—	0.00	Other	0	0
454	EPI.thymic_medullary.stress_APC	0.08	Nonsignificant	0.06	1.65	Other	2	4
455	SMC.activated	0.08	Nonsignificant	1.00	0.88	Other	2	5
456	EPI.renal_principal_cell.canonical_vasopressin	0.08	Nonsignificant	0.99	0.81	Other	2	0
457	EC.capillary.angiocrine	0.08	Nonsignificant	1.00	0.46	Other	250	630
458	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.07	Nonsignificant	—	0.42	Other	0	0
459	MAC.kupffer.tolerogenic	0.07	Nonsignificant	—	0.53	Other	45	49
460	PC.IgG_systemic.metabolic	0.07	Nonsignificant	1.00	0.00	Other	46	63
461	EPI.renal_immature_ureteric_bud.osmoprotective	0.06	Nonsignificant	0.80	0.96	Other	126	44
462	EPI.skin_appendage_keratinocyte.transit_amplifying	0.06	Nonsignificant	—	0.61	Other	109	358
463	NEU.EXC_IT.neuromodulated	0.06	Nonsignificant	0.73	1.12	Other	176	116
464	EPI.ileal_enterocyte_crypt.secretory_precursor	0.06	Nonsignificant	—	0.00	Other	0	0
465	ASTRO.A1_reactive	0.06	Nonsignificant	1.00	0.45	Other	433	394
466	FIB.skin_sheath.ECM_immune	0.06	Nonsignificant	—	0.00	Other	0	0
467	EPI.renal_immature_ureteric_bud.defense_secretory	0.06	Nonsignificant	0.80	0.79	Other	45	76
468	PLAT.adhesion	0.06	Nonsignificant	—	0.00	Other	0	0
469	EC.venous.cardiac_structural	0.06	Nonsignificant	1.00	9.15e-03	Other	102	229
470	EPI.hepatic_ductular_cholangiocyte.polarity	0.05	Nonsignificant	—	0.00	Other	0	0
471	HPC.MEP	0.05	Nonsignificant	1.00	0.00	Other	599	1,195
472	PERI.inflammatory	0.05	Nonsignificant	0.04	1.22	Other	40	77
473	FIB.skin_sheath.stress_chaperone	0.05	Nonsignificant	—	0.44	Other	0	0
474	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.05	Nonsignificant	—	0.97	Other	0	0
475	EPI.pancreatic_ductal_bicarbonate.stress	0.05	Nonsignificant	—	0.87	Other	12	33
476	EC.arterial.arteriole_gas_exchange	0.05	Nonsignificant	1.00	0.79	Other	238	131
477	B.age_associated.naive_transitional	0.05	Nonsignificant	—	0.35	Other	0	0
478	MAC.kupffer.metabolic	0.05	Nonsignificant	—	0.00	Other	25	36
479	MAC.kupffer.inflammatory	0.05	Nonsignificant	—	0.22	Other	7	4
480	EPI.skin_hair_follicle_companion.activated_migratory	0.05	Nonsignificant	—	0.00	Other	0	0
481	MAC.resident_iron.heme_recycling	0.04	Nonsignificant	—	0.00	Other	30	37
482	MAC.resident_repair.chemokine_angiocrine	0.04	Nonsignificant	0.93	0.82	Other	87	138
483	EPI.thymic_medullary.canonical_alarmin	0.04	Nonsignificant	0.23	1.34	Other	8	17
484	EPI.renal_thick_ascending_limb.remodeling	0.04	Nonsignificant	1.00	0.91	Other	152	92
485	EPI.colonocyte.secretory_boost	0.04	Nonsignificant	0.74	1.28	Other	98	91
486	EPI.skin_keratinocyte_progenitor.activated_stress	0.04	Nonsignificant	—	0.00	Other	0	0
487	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.04	Nonsignificant	—	0.00	Other	0	0
488	MEL.neurotrophic_migratory	0.04	Nonsignificant	—	1.80	Other	0	0
489	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.03	Nonsignificant	—	0.00	Other	0	0
490	CHOND.angiogenic	0.03	Nonsignificant	—	0.00	Other	0	0
491	EPI.skin_follicular_keratinizing.root_infundibulum	0.03	Nonsignificant	—	0.71	Other	0	0
492	EPI.pancreatic_islet.delta	0.03	Nonsignificant	—	1.04	Other	0	0
493	EPI.colonocyte.distal_absorptive	0.03	Nonsignificant	—	1.16	Other	0	0
494	NEU.EXC_CT.remodeling	0.03	Nonsignificant	—	0.64	Other	23	1
495	EPI.skin_keratinocyte_basal.basement_anchoring	0.03	Nonsignificant	—	0.00	Other	0	0
496	PERI.baseline	0.03	Nonsignificant	0.99	1.01	Other	39	66
497	EPI.thymic_medullary.hormone_xeno_barrier	0.03	Nonsignificant	—	0.00	Other	0	8
498	EPI.pancreatic_acinar.quiet_dedifferentiation	0.03	Nonsignificant	1.00	0.12	Other	142	171
499	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.03	Nonsignificant	—	0.00	Other	0	0
500	SMC.metabolic	0.02	Nonsignificant	1.00	0.38	Other	14	40
501	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.02	Nonsignificant	—	0.32	Other	0	0
502	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.02	Nonsignificant	6.18e-03	1.21	Other	11	22
503	EPI.alveolar_type_1.activated	0.02	Nonsignificant	—	1.64	Other	0	0
504	EC.arterial.ion_pump	0.02	Nonsignificant	0.73	0.95	Other	3	2
505	EPI.pancreatic_islet.beta	0.02	Nonsignificant	0.51	1.12	Other	42	57
506	EPI.skin_follicular_keratinizing.upper_infundibulum	0.02	Nonsignificant	—	0.15	Other	8	2
507	EPI.lung_multiciliated.mature_motile_cilia	0.02	Nonsignificant	—	0.00	Other	0	0
508	CHOND.pro_inflammatory	0.02	Nonsignificant	1.00	0.44	Other	181	351
509	MAC.kupffer.stress	0.02	Nonsignificant	0.96	0.34	Other	9	3
510	FIB.suburothelial.urothelial_interface	0.02	Nonsignificant	1.00	0.00	Other	9	8
511	EPI.colonic_tuft.activated	0.02	Nonsignificant	—	0.00	Other	0	0
512	EPI.thymic_medullary.proliferative_APC	0.02	Nonsignificant	—	0.00	Other	0	0
513	EC.lymphatic.baseline	0.02	Nonsignificant	0.43	1.42	Other	38	72
514	NEU.INH_VIP.enkephalinergic	0.02	Nonsignificant	—	1.42	Other	0	0
515	EPI.renal_intercalated_cell_type_A.acid_secretion	0.02	Nonsignificant	0.42	1.09	Other	12	6
516	MAC.resident_repair.ECM_stromal_crosstalk	0.02	Nonsignificant	0.93	0.86	Other	95	158
517	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	1.44	Other	1	9
518	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.01	Nonsignificant	—	0.00	Other	0	0
519	EPI.endocervical_secretory.squamous_barrier	0.01	Nonsignificant	—	0.67	Other	0	0
520	EPI.tracheal_suprabasal.secretory_immune	0.01	Nonsignificant	—	0.38	Other	0	0
521	EPI.colonocyte.crypt_progenitor	0.01	Nonsignificant	0.81	1.02	Other	115	265
522	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.01	Nonsignificant	—	0.81	Other	0	0
523	B.age_associated.activated	0.01	Nonsignificant	—	0.00	Other	18	22
524	EPI.renal_principal_cell.injury_repair	0.01	Nonsignificant	0.99	0.31	Other	26	9
525	EPI.pancreatic_ductal_perivascular.baseline	0.01	Nonsignificant	0.17	1.45	Other	1	5
526	EPI.colonocyte.ionocyte_BEST4	0.01	Nonsignificant	0.76	1.18	Other	103	188
527	EPI.renal_intercalated_cell_type_A.PC_transitional	0.01	Nonsignificant	—	0.15	Other	203	407
528	FIB.skin_sheath.neuro_vascular_interface	9.93e-03	Nonsignificant	—	0.00	Other	0	0
529	IPSC.neural_primed	9.87e-03	Nonsignificant	0.68	1.09	Other	0	0
530	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	9.84e-03	Nonsignificant	0.57	1.19	Other	2	9
531	EPI.pancreatic_ductal_progenitor.ADM_like	9.58e-03	Nonsignificant	—	1.32	Other	0	0
532	EPI.renal_thick_ascending_limb.salt_sensing	9.25e-03	Nonsignificant	1.00	0.83	Other	73	103
533	EPI.renal_principal_cell.intercalated_like	8.90e-03	Nonsignificant	0.99	0.41	Other	63	66
534	EPI.skin_hair_follicle_bulge.anagen_growth	8.54e-03	Nonsignificant	—	0.27	Other	0	0
535	EPI.renal_distal_tubule.ion_transport	8.42e-03	Nonsignificant	—	0.00	Other	0	0
536	NEU.INH_VIP.serotonergic	7.90e-03	Nonsignificant	—	0.88	Other	9	2
537	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	7.86e-03	Nonsignificant	0.99	0.34	Other	33	34
538	PERI.angiocrine	7.76e-03	Nonsignificant	1.00	0.79	Other	93	102
539	EPI.colonocyte.proximal_transport	7.72e-03	Nonsignificant	0.99	0.80	Other	24	12
540	EPI.skin_sebaceous_duct_luminal.detox_repair	7.46e-03	Nonsignificant	0.63	0.98	Other	137	94
541	EPI.renal_thick_ascending_limb.cation_flux	6.90e-03	Nonsignificant	1.00	0.91	Other	57	95
542	EPI.pancreatic_ductal_bicarbonate.baseline	6.82e-03	Nonsignificant	0.85	1.01	Other	11	42
543	EC.liver_sinusoidal.stress	6.71e-03	Nonsignificant	—	0.46	Other	413	158
544	EC.liver_sinusoidal.prostanoid	6.46e-03	Nonsignificant	—	0.00	Other	11	64
545	EPI.skin_keratinocyte_proliferating.anchor_remodel	6.35e-03	Nonsignificant	—	0.00	Other	0	0
546	EPI.skin_hair_follicle_bulge.quiescent	6.19e-03	Nonsignificant	1.00	0.00	Other	56	69
547	MAC.kupffer.fibrogenic	5.39e-03	Nonsignificant	—	0.00	Other	0	0
548	EPI.skin_follicular_keratinizing.transit_amplifying	5.38e-03	Nonsignificant	—	0.00	Other	21	49
549	NEU.INH_VIP.develop_niche	5.26e-03	Nonsignificant	—	1.08	Other	0	0
550	EPI.gastric_foveolar.baseline	5.00e-03	Nonsignificant	—	0.00	Other	0	0
551	FIB.skin_tenogenic.baseline	4.83e-03	Nonsignificant	—	0.00	Other	0	2
552	CM.osmoprotection	4.79e-03	Nonsignificant	0.59	1.06	Other	34	57
553	EC.liver_sinusoidal.secretory_lipoprotein	4.46e-03	Nonsignificant	1.00	0.85	Other	120	70
554	IPSC.midbrain_primed	3.97e-03	Nonsignificant	0.86	1.06	Other	0	0
555	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	3.92e-03	Nonsignificant	—	0.00	Other	0	0
556	NEU.EXC_IT.structural	3.73e-03	Nonsignificant	0.73	1.05	Other	171	41
557	EPI.pancreatic_ductal_perivascular.protective_antioxidant	3.64e-03	Nonsignificant	—	0.00	Other	11	69
558	ASTRO.neuromodulatory	3.62e-03	Nonsignificant	1.00	0.08	Other	34	172
559	IPSC.neuroendocrine_primed	3.49e-03	Nonsignificant	—	1.90	Other	0	0
560	PERI.cardiac_skeletal	3.45e-03	Nonsignificant	1.00	0.46	Other	313	630
561	EPI.ileal_goblet.inflammatory_mucin	3.32e-03	Nonsignificant	0.83	1.12	Other	6	9
562	DC.pDC.immature_metabolic	3.21e-03	Nonsignificant	0.04	1.43	Other	78	124
563	EPI.colonocyte.junction_remodeling	3.07e-03	Nonsignificant	0.99	0.47	Other	218	305
564	EPI.colonic_enteroendocrine.progenitor	3.07e-03	Nonsignificant	—	0.00	Other	0	0
565	FIB.skin_papillary.baseline	2.87e-03	Nonsignificant	—	0.00	Other	0	0
566	MAC.resident_cardiac.antigen_presenting	2.86e-03	Nonsignificant	0.31	1.17	Other	52	27
567	CM.mito_proteostasis	2.85e-03	Nonsignificant	4.90e-03	1.11	Other	329	29
568	EPI.alveolar_type_1.baseline	2.74e-03	Nonsignificant	1.00	0.00	Other	8	0
569	EC.lymphatic.scavenger	2.72e-03	Nonsignificant	0.81	0.92	Other	203	257
570	EC.lymphatic.activated	2.62e-03	Nonsignificant	0.83	0.61	Other	47	73
571	EPI.salivary_duct_excretory.baseline	2.56e-03	Nonsignificant	0.49	1.15	Other	23	57
572	EC.liver_sinusoidal.remodeling_lipotoxicity	2.42e-03	Nonsignificant	—	0.00	Other	90	58
573	MEL.dedifferentiated_migratory	2.40e-03	Nonsignificant	—	0.37	Other	0	0
574	GRNLSA.angiocrine_mechanosensory	1.88e-03	Nonsignificant	—	0.00	Other	0	0
575	EC.lymphatic.tip_migratory	1.86e-03	Nonsignificant	0.81	0.84	Other	23	37
576	NEU.INH_VIP.excitatory_coupled	1.68e-03	Nonsignificant	—	0.19	Other	13	0
577	EPI.renal_proximal_tubule.onecarbon_peroxisome	1.67e-03	Nonsignificant	0.39	1.40	Other	58	89
578	EPI.renal_proximal_tubule.detox_antioxidant	1.51e-03	Nonsignificant	0.81	0.56	Other	394	77
579	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.46e-03	Nonsignificant	—	0.00	Other	0	0
580	CM.contractile_oxphos	1.41e-03	Nonsignificant	0.84	1.05	Other	6	19
581	IPSC.stress	1.33e-03	Nonsignificant	0.86	1.08	Other	0	0
582	OLG.stress	1.20e-03	Nonsignificant	0.66	1.11	Other	232	8
583	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.18e-03	Nonsignificant	—	0.00	Other	39	82
584	MAC.resident_cardiac.inflammatory_reparative	1.16e-03	Nonsignificant	0.31	1.17	Other	31	96
585	OPC.homeostatic	1.13e-03	Nonsignificant	0.03	1.36	Other	394	160
586	MEL.stress_glucocorticoid	1.05e-03	Nonsignificant	0.98	0.90	Other	11	34
587	EPI.salivary_serous_acinar.seromucous_like	1.03e-03	Nonsignificant	—	1.44	Other	0	0
588	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.00e-03	Nonsignificant	—	0.87	Other	0	0
589	IPSC.endoderm_primed	9.96e-04	Nonsignificant	0.86	1.10	Other	0	0
590	DC.pDC.poised_migratory	9.54e-04	Nonsignificant	0.54	1.08	Other	54	95
591	DC.pDC.baseline	9.10e-04	Nonsignificant	0.54	1.11	Other	88	123
592	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	8.58e-04	Nonsignificant	—	0.63	Other	0	0
593	EPI.salivary_serous_acinar.secretory_active	8.31e-04	Nonsignificant	0.55	0.98	Other	242	69
594	EPI.tracheal_suprabasal.transitional_wound	8.10e-04	Nonsignificant	—	0.00	Other	16	1
595	EPI.endocervical_secretory.secretory_translocon	7.34e-04	Nonsignificant	—	0.00	Other	0	0
596	IPSC.mesenchymal_primed	7.32e-04	Nonsignificant	0.99	0.99	Other	0	0
597	OPC.proliferative_immune_interact	6.72e-04	Nonsignificant	0.45	1.22	Other	180	373
598	NEU.INH_VIP.opioid	6.40e-04	Nonsignificant	—	0.00	Other	50	9
599	IPSC.mesendo_primed	6.28e-04	Nonsignificant	0.86	1.00	Other	0	0
600	MEL.secretory_quiescent	6.10e-04	Nonsignificant	0.98	0.57	Other	19	13
601	EPI.pancreatic_ductal_progenitor.baseline	5.47e-04	Nonsignificant	0.91	0.56	Other	179	702
602	EC.liver_sinusoidal.hypoxia_metabolic	5.15e-04	Nonsignificant	1.00	0.19	Other	183	107
603	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	5.07e-04	Nonsignificant	0.85	0.92	Other	219	533
604	CM.baseline	5.07e-04	Nonsignificant	0.84	1.00	Other	393	0
605	IPSC.mesodermal_primed	4.97e-04	Nonsignificant	0.86	1.03	Other	0	0
606	EPI.salivary_serous_acinar.quiescent	4.87e-04	Nonsignificant	0.55	1.04	Other	178	493
607	NEU.INH_LAMP5.projecting	4.80e-04	Nonsignificant	—	1.16	Other	0	0
608	EPI.pancreatic_ductal_bicarbonate.activated	4.77e-04	Nonsignificant	0.85	0.95	Other	10	7
609	EPI.salivary_myoepithelial.junctional_transport	4.33e-04	Nonsignificant	0.98	1.02	Other	66	121
610	MAC.resident_cardiac.phagocytic_homeostasis	3.92e-04	Nonsignificant	1.00	0.60	Other	564	1,221
611	NEU.INH_VIP.regulatory_remodeling	3.81e-04	Nonsignificant	—	0.00	Other	6	1
612	CM.oxidative_phospho	3.80e-04	Nonsignificant	0.09	1.09	Other	266	792
613	EPI.pancreatic_islet.alpha	3.68e-04	Nonsignificant	—	0.00	Other	152	330
614	MEL.mature_oxidative_traffic	3.60e-04	Nonsignificant	0.98	0.32	Other	247	285
615	EPI.ileal_goblet.baseline	3.37e-04	Nonsignificant	0.89	0.52	Other	16	2
616	NEU.INH_VIP.canonical_disinhibitory	3.33e-04	Nonsignificant	0.90	0.50	Other	59	38
617	EPI.ileal_goblet.stress_metallothionein	3.06e-04	Nonsignificant	—	0.00	Other	4	11
618	EC.heart_remodeling.remodeling_secretory	3.01e-04	Nonsignificant	0.95	1.06	Other	605	1,341
619	OPC.premyelinating	2.69e-04	Nonsignificant	0.54	0.99	Other	185	12
620	CM.anti_inflammatory	2.66e-04	Nonsignificant	0.01	1.10	Other	424	1,503
621	NEU.INH_VIP.matrix	2.61e-04	Nonsignificant	—	0.00	Other	24	77
622	EPI.tracheal_basal.activated_stress	2.60e-04	Nonsignificant	0.12	1.35	Other	32	0
623	EPI.salivary_intercalated_defense.inflammatory	2.27e-04	Nonsignificant	0.99	0.51	Other	152	360
624	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.23e-04	Nonsignificant	0.85	0.66	Other	40	191
625	OLG.regulatory_activated	2.21e-04	Nonsignificant	0.66	1.16	Other	196	614
626	EC.heart_remodeling.translation_boost	1.99e-04	Nonsignificant	—	0.38	Other	0	0
627	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.82e-04	Nonsignificant	—	0.00	Other	0	0
628	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.82e-04	Nonsignificant	1.00	0.32	Other	322	317
629	OLG.myelinating_mature	1.77e-04	Nonsignificant	1.00	1.02	Other	363	94
630	NEU.EXC_CT.projector	1.75e-04	Nonsignificant	0.98	0.46	Other	87	26
631	NEU.INH_VIP.nuclear_reg	1.67e-04	Nonsignificant	—	0.00	Other	20	4
632	NEU.EXC_CT.Ca2_signaling	1.51e-04	Nonsignificant	—	0.00	Other	68	17
633	IPSC.axial_identity_primed	1.41e-04	Nonsignificant	1.00	0.95	Other	0	0
634	NEU.INH_PVALB.fastspike	1.41e-04	Nonsignificant	—	0.20	Other	24	22
635	CM.sarcomere_actin_interface	1.39e-04	Nonsignificant	0.94	0.94	Other	450	78
636	CM.mechano_activated	1.35e-04	Nonsignificant	0.94	0.94	Other	205	134
637	EPI.salivary_myoepithelial.baseline	1.33e-04	Nonsignificant	0.98	0.74	Other	42	141
638	EPI.salivary_duct_excretory.stress	1.26e-04	Nonsignificant	0.78	0.69	Other	33	68
639	NEU.INH_PVALB.chandelier	9.83e-05	Nonsignificant	0.52	1.21	Other	19	16
640	IPSC.canonical_pluripotent	9.06e-05	Nonsignificant	1.00	0.88	Other	0	0
641	EC.heart_remodeling.perivascular	7.93e-05	Nonsignificant	0.98	0.93	Other	124	408
642	NEU.EXC_IT.transitional	7.40e-05	Nonsignificant	1.00	0.95	Other	237	142
643	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	7.21e-05	Nonsignificant	—	0.32	Other	0	0
644	EPI.salivary_myoepithelial.activated	6.74e-05	Nonsignificant	0.98	0.50	Other	85	281
645	NEU.INH_LAMP5.exc_inh_balance	6.66e-05	Nonsignificant	—	0.00	Other	46	2
646	EPI.tracheal_basal.homeostatic_progenitor	6.60e-05	Nonsignificant	0.96	0.44	Other	285	74
647	NEU.INH_VIP.cannabinoid	6.51e-05	Nonsignificant	—	0.00	Other	0	0
648	EPI.pancreatic_ductal_progenitor.ciliated_transport	5.89e-05	Nonsignificant	—	0.00	Other	105	368
649	CM.translation_boost_RPL	5.83e-05	Nonsignificant	0.94	0.95	Other	129	1
650	CM.inflammatory	5.74e-05	Nonsignificant	—	0.89	Other	0	0
651	EPI.colonocyte.goblet_interface	5.72e-05	Nonsignificant	—	0.00	Other	11	21
652	NEU.EXC_SYT2.synaptic	5.62e-05	Nonsignificant	—	0.00	Other	0	0
653	EPI.bile_duct_cholangiocyte.inflammatory_APC	5.50e-05	Nonsignificant	—	0.17	Other	2	0
654	EPI.extrahepatic_cholangiocyte.barrier_interface	5.39e-05	Nonsignificant	—	0.00	Other	0	0
655	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	5.34e-05	Nonsignificant	0.95	0.21	Other	449	1,034
656	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	4.77e-05	Nonsignificant	—	0.00	Other	49	237
657	NEU.INH_PVALB.metabotropic	4.55e-05	Nonsignificant	—	0.21	Other	0	0
658	EPI.salivary_mucous_acinar.baseline	4.40e-05	Nonsignificant	—	—	Other	394	683
659	EPI.bile_duct_cholangiocyte.secretory_mucin	4.19e-05	Nonsignificant	—	0.00	Other	7	12
660	NEU.EXC_IT.callosal	3.89e-05	Nonsignificant	1.00	0.93	Other	286	119
661	NEU.INH_PVALB.neuromodulatory	2.98e-05	Nonsignificant	—	0.41	Other	0	0
662	NEU.INH_PVALB.nuclear_reg	2.79e-05	Nonsignificant	0.64	0.95	Other	25	12
663	IPSC.stromal_primed	1.88e-05	Nonsignificant	0.99	0.97	Other	0	0
664	EC.heart_remodeling.angiocrine	1.87e-05	Nonsignificant	0.98	0.66	Other	182	525
665	NEU.INH_LAMP5.rosehip	1.74e-05	Nonsignificant	—	6.94e-17	Other	0	0
666	NEU.INH_LAMP5.glial_interface	1.72e-05	Nonsignificant	—	0.00	Other	0	0
667	OLG.myelinating_stress	1.65e-05	Nonsignificant	1.00	0.97	Other	232	62
668	EC.heart_remodeling.remodeling_stalk	1.58e-05	Nonsignificant	0.98	0.72	Other	33	111
669	EPI.skin_sebaceous_duct_luminal.immune_interface	1.56e-05	Nonsignificant	—	0.00	Other	0	0
670	OLG.regulatory	1.28e-05	Nonsignificant	1.00	0.88	Other	353	73
671	EPI.skin_keratinocyte_proliferating.detox_repair	1.20e-05	Nonsignificant	—	0.00	Other	0	0
672	NEU.INH_PVALB.serotonergic	7.50e-06	Nonsignificant	—	0.00	Other	0	0
673	EPI.thymic_cortical.secretory_remodeling	6.74e-06	Nonsignificant	—	1.14	Other	4	1
674	OLG.vesicle_trafficking	6.31e-06	Nonsignificant	1.00	0.91	Other	124	10
675	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	3.70e-06	Nonsignificant	—	0.00	Other	0	0
676	EPI.extrahepatic_cholangiocyte.mucin_secretory	3.27e-06	Nonsignificant	—	0.00	Other	0	0
677	IPSC.proliferative	2.17e-06	Nonsignificant	1.00	0.89	Other	0	0
678	CM.translation_boost_RPS	2.06e-06	Nonsignificant	0.94	0.83	Other	69	16
679	EC.heart_remodeling.capillary_metabolic	1.93e-06	Nonsignificant	0.98	0.86	Other	54	414
680	OLG.reactive_repair	1.17e-06	Nonsignificant	1.00	0.57	Other	385	385
681	NEU.EXC_SYT2.nuclear_reg	4.17e-07	Nonsignificant	—	0.00	Other	0	0
682	NEU.EXC_IT.adhesion	2.90e-07	Nonsignificant	1.00	0.83	Other	252	108
683	EPI.salivary_intercalated_defense.basal_EMT	1.20e-07	Nonsignificant	—	0.00	Other	0	0
684	NEU.EXC_NTNG1.synaptic	1.06e-07	Nonsignificant	—	0.67	Other	0	0
685	NEU.EXC_NTNG1.nuclear_reg	2.10e-08	Nonsignificant	—	0.00	Other	0	0
686	NEU.EXC_IT.guidance	9.79e-10	Nonsignificant	1.00	0.34	Other	274	63
687	EPI.thymic_cortical.baseline	2.16e-10	Nonsignificant	0.91	0.44	Other	185	386
688	EPI.thymic_cortical.Notch_interface	1.29e-10	Nonsignificant	—	0.00	Other	82	137

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

162 unique genes. Showing 1–162. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
MICB	01-High	0.67	7.98	G1	C1	—	T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant)	43 cells — complete matches	294	633
NCR3	01-High	0.64	6.31	G1	C1	T.CD4_transitional.tissue_enagement (L2), T.CD8_Tcm.NK_like (L2), T.CD8_Tem.TEMRA (L2)	T_cell (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_naive (Tier: specific) T.CD8_Tcm (Tier: specific) NK.cytokine_tissue_activation (Tier: specific) NK.cytokine_tissue_resident (Tier: specific) NK.immature_bridge (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD4_Treg (Tier: relevant) T.CD8_Trm (Tier: relevant) T.MAIT (Tier: relevant) T.CD4_naive.survival (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.Tfh_like (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	104 cells — complete matches	261	542
NSMCE1	01-High	0.64	8.77	G1	C1	—	—	T.CD4_cytotoxic.NK_adapted (L2)	12	35
SIPA1	01-High	0.60	3.76	G1	C1	—	T.MAIT (Tier: relevant)	6 cells — complete matches	103	359
IL18R1	01-High	0.60	8.74	G1	C1	MAC.resident_cardiac.antigen_presenting (L2)	T.CD4_Trm (Tier: specific) NK.cytokine_tissue_resident (Tier: specific) NK.immature_bridge (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant) T.CD4_naive.survival (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	60 cells — complete matches	52	145
TRIM8	01-High	0.57	8.50	G1	C1	—	T.CD4_Tcm.Th2_like (Tier: relevant)	4 cells — complete matches	29	67
AP5B1	01-High	0.57	8.53	G1	C1	—	T.CD4_transitional (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	23 cells — complete matches	20	61
TCF19	01-High	0.53	5.39	G1	C1	EPI.esophageal_suprabasal.proliferative_S (L2), HEP.acute_phase.proliferative (L2)	B.germinal_center (Tier: specific) T.CD4_transitional (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	46 cells — complete matches	196	428
ENSG00000309474	01-High	0.53	3.42	G1	C1	—	—	—	83	318
CTSW	01-High	0.53	3.98	G1	C1	T.CD4_cytotoxic (L1S), T.CD8_Tem (L1S), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_cytotoxic.terminal_effector (L2), T.CD8_Tem.baseline (L2)	T_cell (Tier: specific) MAC.alveolar (Tier: specific) T.CD4_Th17 (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_naive (Tier: specific) T.CD8_Tcm (Tier: specific) NK.cytokine_tissue_activation (Tier: specific) NK.cytokine_tissue_resident (Tier: specific) NK.immature_bridge (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD8_Trm (Tier: relevant) T.MAIT (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_naive.effector_transition (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	123 cells — complete matches	22	46
SNX32	01-High	0.52	9.62	G1	C1	—	—	10 cells — complete matches	14	34
ENSG00000302979	01-High	0.51	9.91	G1	C1	—	—	—	17	34
ENSG00000305207	01-High	0.51	4.38	G1	C1	—	—	—	24	51
FIBP	01-High	0.51	4.38	G1	C1	—	—	T.CD4_Tcm.APC_mimicry (L2), T.CD8_Tcm.gut_homing (L2)	24	51
CFL1	01-High	0.51	6.89	G1	C1	NEU.EXC_SYT2.synaptic (L2), PLAT.adhesion (L2), THYMO.proliferative_S (L2)	—	9 cells — complete matches	24	101
MUS81	01-High	0.50	6.53	G1	C1	—	—	5 cells — complete matches	16	42
ENSG00000303001	01-High	0.50	9.60	G1	C1	—	—	—	7	17
EFEMP2	01-High	0.50	5.18	G1	C1	—	T.CD4_transitional (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant)	16 cells — complete matches	50	111
IL18RAP	01-High	0.49	6.11	G1	C1	—	T_cell (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tcm (Tier: specific) NK.cytokine_tissue_activation (Tier: specific) NK.cytokine_tissue_resident (Tier: specific) NK.immature_bridge (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD8_Trm (Tier: relevant) T.MAIT (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	84 cells — complete matches	48	140
FOSL1	01-High	0.48	4.78	G1	C1	EC.arterial.inflammatory (L2), EPI.colonocyte.junction_remodeling (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), EPI.thymic_medullary.stress_APC (L2), EPI.tracheal_basal.homeostatic_progenitor (L2)	EC.venous.activated (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD4_transitional (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	74 cells — complete matches	26	51
CCDC85B	01-High	0.48	3.81	G1	C1	—	—	17 cells — complete matches	24	56
KAT5	01-High	0.47	8.46	G1	C1	—	—	FIB.transitioning.motility_remodelling (L2)	55	212
ENSG00000297087	01-High	0.47	4.13	G1	C1	—	—	—	19	40
DRAP1	01-High	0.45	4.48	G1	C1	—	—	—	21	40
C11orf68	01-High	0.45	4.48	G1	C1	—	T.CD8_Tcm (Tier: specific) B.germinal_center.LZ_memory_precursor (Tier: relevant) T.CD4_naive.survival (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	16 cells — complete matches	21	46
SART1	01-High	0.45	4.15	G1	C1	—	—	5 cells — complete matches	20	39
ENSG00000297007	01-High	0.43	5.57	G1	C1	—	—	—	6	16
CATSPER1	01-High	0.43	3.72	G1	C1	—	NK.cytokine_tissue_activation (Tier: specific) NK.immature_bridge (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant)	68 cells — complete matches	16	32
BANF1	01-High	0.41	3.69	G1	C1	—	—	EPI.colonic_tuft.homeostatic (L2), FIB.transitioning.ISG_primed_interface (L2)	14	48
EIF1AD	01-High	0.41	3.64	G1	C1	—	T.CD4_Trm.metal_stress (Tier: relevant)	6 cells — complete matches	10	27
CST6	01-High	0.41	3.37	G1	C1	EPI.skin_sweat_duct_keratinocyte.barrier (L2)	—	44 cells — complete matches	10	22
TLR1	02-Medium	0.65	14.42	G1	C2	—	T.CD4_Tem.long_term_memory (Tier: specific) T.CD4_Tcm.stress (Tier: relevant)	54 cells — complete matches	33	59
HLA-DQB1	02-Medium	0.56	8.61	G1	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	B.germinal_center (Tier: specific) MAC.alveolar (Tier: specific) EC.venous.activated (Tier: specific) DC.mig (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD4_Treg (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant)	133 cells — complete matches	703	1,314
ENSG00000306984	02-Medium	0.56	12.22	G1	C2	—	—	—	16	28
ENSG00000298426	02-Medium	0.55	6.54	G2	C1	—	—	—	317	607
HCG27	02-Medium	0.55	8.22	G1	C2	—	T.CD4_Tem.long_term_memory (Tier: specific) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	37 cells — complete matches	119	287
MICB-DT	02-Medium	0.54	7.71	G1	C2	—	—	—	131	286
ENSG00000303029	02-Medium	0.53	5.94	G1	C2	—	—	—	234	380
ENSG00000308816	02-Medium	0.52	12.14	G1	C2	—	—	—	18	30
TLR6	02-Medium	0.52	15.64	G2	C2	—	T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	51 cells — complete matches	18	30
POU5F1	02-Medium	0.52	7.14	G1	C2	induced_pluripotent_stem_cell (L1), IPSC.induced_pluripotent_stem_cell (L1S), IPSC.canonical_pluripotent (L2), IPSC.endoderm_primed (L2)	—	10 cells — complete matches	107	259
ENSG00000298871	02-Medium	0.52	17.83	G2	C2	—	—	—	17	29
MFSD13A	02-Medium	0.51	8.31	G1	C2	—	T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant)	25 cells — complete matches	36	44
TNF	02-Medium	0.51	4.98	G2	C1	B.naive.activated (L2), EC.capillary.inflammatory (L2), EPI.ectocervical_granular.inflammatory (L2), EPI.renal_principal_cell.inflammatory (L2), ILC2.activated (L2), MAC.alveolar.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2), T.CD4_Trm.activated (L2), T.CD4_cytotoxic.NK_adapted (L2), T.CD8_Trm.inflammatory (L2)	T_cell (Tier: specific) MAC.alveolar (Tier: specific) T.CD4_naive (Tier: specific) T.CD4_Th17 (Tier: specific) T.CD4_Trm (Tier: specific) NK.cytokine_tissue_activation (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD8_Trm (Tier: relevant) T.MAIT (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	111 cells — complete matches	75	194
HLA-C	02-Medium	0.50	6.26	G2	C1	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	NK.cytokine_tissue_resident (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.MAIT (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	76 cells — complete matches	738	1,070
ENSG00000309733	02-Medium	0.50	8.38	G1	C2	—	—	—	468	929
IL1R1	02-Medium	0.50	8.78	G1	C2	FIB.adventitial.inflammatory_activated (L2), HEP.periportal_metabolic.stress_checkpoint (L2)	EC.venous.activated (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD4_Treg (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	58 cells — complete matches	24	48
IL1RL1	02-Medium	0.49	9.38	G1	C2	T.CD4_Th2 (L1S)	EC.venous.activated (Tier: specific) T.CD4_transitional.tissue_enagement (Tier: relevant)	46 cells — complete matches	43	110
TLR10	02-Medium	0.49	13.31	G2	C2	—	B.germinal_center (Tier: specific) B.germinal_center.LZ_memory_precursor (Tier: relevant)	50 cells — complete matches	18	30
ACTR1A	02-Medium	0.48	8.77	G1	C2	—	—	B.naive.receptor_recycle (L2)	43	60
MIR6891	02-Medium	0.48	8.58	G2	C1	—	—	—	474	812
SEPTIN8	02-Medium	0.48	9.58	G1	C2	—	—	—	109	187
ENSG00000285647	02-Medium	0.48	8.78	G2	C1	—	—	—	364	611
ENSG00000271581	02-Medium	0.48	8.58	G2	C1	—	—	—	348	596
HLA-B	02-Medium	0.47	8.09	G2	C1	EC.heart_remodeling.remodeling_stalk (L2), EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), FIB.skin_sheath.ECM_immune (L2), OPC.proliferative_immune_interact (L2), SMC.metabolic (L2)	T_cell (Tier: specific) T.CD4_naive (Tier: specific) T.CD4_Trm (Tier: specific) EC.venous.activated (Tier: specific) T.CD4_naive.mature_mitoprot (Tier: specific) T.CD4_naive.neddylation (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.gamma_delta.central_memory (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD8_Trm (Tier: relevant) T.CD4_naive.proteostasis_mitoprot (Tier: relevant) T.CD4_naive.survival (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	130 cells — complete matches	493	836
MICA-AS1	02-Medium	0.47	8.26	G1	C2	—	—	—	210	470
ENSG00000306250	02-Medium	0.47	8.34	G1	C2	—	—	—	33	73
IRF1	02-Medium	0.47	3.94	G1	C2	EC.arterial.inflammatory (L2), EPI.renal_principal_cell.activated_acute (L2), EPI.skin_interfollicular_spinous.early_differentiation (L2), FIB.hepatic_stellate_cell.inflammatory (L2), FIB.interstitial.immune_interact (L2), FIB.neurolectin_mucosa.inflammatory (L2), HEP.acute_phase.inflammatory (L2), PC.IgA_muocsal.plasmablast (L2)	NK.immature_bridge (Tier: specific)	25 cells — complete matches	618	847
ENSG00000283782	02-Medium	0.47	3.66	G1	C2	—	—	—	374	500
PSORS1C3	02-Medium	0.47	6.91	G1	C2	—	—	—	124	315
ENSG00000296990	02-Medium	0.46	16.70	G1	C2	—	—	—	3	3
OVOL1	02-Medium	0.46	8.71	G1	C2	—	—	37 cells — complete matches	6	8
LINC02757	02-Medium	0.46	15.02	G2	C2	—	—	—	4	7
CCHCR1	02-Medium	0.45	5.83	G1	C2	—	T.CD4_Tem (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	13 cells — complete matches	146	317
IL4R	02-Medium	0.45	8.91	G1	C2	B.naive (L1S), B.naive.baseline (L2)	T.CD4_naive.mature_mitoprot (Tier: specific) T.CD4_naive.proteostasis_mitoprot (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant)	46 cells — complete matches	9	47
IL1RL2	02-Medium	0.45	9.54	G1	C2	—	—	11 cells — complete matches	38	79
CARINH	02-Medium	0.45	3.34	G1	C2	—	—	—	411	545
ENSG00000288587	02-Medium	0.45	6.42	G1	C2	—	—	—	257	555
IL2	02-Medium	0.45	8.07	G2	C1	—	T_cell (Tier: specific) T.CD4_Tcm (Tier: specific) T.CD4_Trm (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.CD8_Trm (Tier: relevant) T.MAIT (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	56 cells — complete matches	2	2
MICA	02-Medium	0.44	6.21	G1	C2	—	—	7 cells — complete matches	277	593
KDM8	02-Medium	0.44	8.06	G1	C2	—	T.CD4_naive.survival (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant)	33 cells — complete matches	5	9
WDR36	02-Medium	0.44	9.83	G2	C2	—	T.CD4_Tcm.stress (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	9 cells — complete matches	0	0
ENSG00000308001	02-Medium	0.43	14.06	G2	C2	—	—	—	2	2
ENSG00000236304	02-Medium	0.43	16.17	G1	C2	—	—	—	1	8
ENSG00000293281	02-Medium	0.43	8.91	G2	C1	—	—	—	16	20
SUFU	02-Medium	0.43	8.50	G2	C2	—	T.CD4_Tcm (Tier: specific) T.CD4_Tcm.imprinted_splicing (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tcm.Tfh_like (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	21 cells — complete matches	43	60
C10orf95	02-Medium	0.43	8.45	G1	C2	—	—	14 cells — complete matches	35	43
DHFRP2	02-Medium	0.42	8.25	G2	C1	—	—	—	16	20
MIR146B	02-Medium	0.42	9.30	G1	C2	—	—	—	37	44
CUEDC2	02-Medium	0.42	8.50	G1	C2	—	—	4 cells — complete matches	35	46
CCNI2	02-Medium	0.42	7.60	G2	C2	—	T.CD8_Tcm (Tier: specific) T.CD4_Treg (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	46 cells — complete matches	1	1
ENSG00000298170	02-Medium	0.42	3.91	G1	C2	—	—	—	353	447
ENSG00000274092	02-Medium	0.42	8.51	G1	C2	—	—	—	5	8
FBXL15	02-Medium	0.42	8.53	G1	C2	—	T.CD8_Trm (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant)	26 cells — complete matches	37	45
KIF3A	02-Medium	0.42	8.73	G2	C2	—	T.CD4_Tem.long_term_memory (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant)	14 cells — complete matches	132	203
LINC02863	02-Medium	0.41	3.89	G1	C2	—	—	—	360	492
ENSG00000298782	02-Medium	0.41	7.51	G1	C2	—	—	—	4	8
C10orf95-AS1	02-Medium	0.41	7.72	G1	C2	—	—	—	37	44
DEXI	02-Medium	0.41	1.73	G2	C1	—	T.CD4_naive.neddylation (Tier: specific)	6 cells — complete matches	27	61
PSD	02-Medium	0.41	8.03	G1	C2	—	T.CD8_naive (Tier: specific) T.CD4_naive.proteostasis_mitoprot (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD8_naive.effector_transition (Tier: relevant)	39 cells — complete matches	35	43
IL1R2	02-Medium	0.41	9.07	G1	C2	DC.cDC2.pro_inflammatory (L2), EPI.esophageal_suprabasal.basal_transitional (L2), EPI.skin_follicular_keratinizing.transit_amplifying (L2), EPI.skin_keratinocyte_proliferating.detox_repair (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), MAC.MDM.APC_dendritic (L2), T.CD4_Treg.tissue_effector (L2)	T.CD4_Treg (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant)	78 cells — complete matches	24	43
ENSG00000298457	02-Medium	0.40	8.34	G2	C1	—	—	—	51	155
NSMCE1-DT	02-Medium	0.40	7.41	G1	C2	—	—	—	4	8
ENSG00000298413	02-Medium	0.40	8.43	G1	C2	—	—	—	37	44
ENSG00000304533	02-Medium	0.40	9.25	G1	C2	—	—	—	32	88
NFKB2	02-Medium	0.40	7.79	G1	C2	EPI.pancreatic_ductal_bicarbonate.inflammatory (L2), FIB.suburothelial.inflammatory_prostanoid (L2), HEP.acute_phase.inflammatory (L2)	—	15 cells — complete matches	46	66
ENSG00000272501	02-Medium	0.40	7.86	G2	C1	—	—	—	151	319
HLA-DQA1	02-Medium	0.40	8.50	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), MAC.resident_iron.APC_iron_sensing (L2), MONO.CD14.APC_like (L2), MONO.CD16.hepatic_mac_like (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2)	B.germinal_center (Tier: specific) MAC.alveolar (Tier: specific) EC.venous.activated (Tier: specific) DC.mig (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_Treg (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant)	159 cells — complete matches	608	1,232
SFXN2	02-Medium	0.40	8.16	G1	C2	—	T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant)	25 cells — complete matches	11	29
ATP6V1G2	02-Medium	0.39	5.77	G2	C2	—	T.CD4_Treg (Tier: relevant)	12 cells — complete matches	73	194
ATP6V1G2-DDX39B	02-Medium	0.39	5.70	G2	C2	—	T.CD4_Treg (Tier: relevant)	11 cells — complete matches	69	185
LRRC32	02-Medium	0.39	12.30	G1	C2	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro (L2)	EC.venous.activated (Tier: specific) T.CD4_Treg (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant)	54 cells — complete matches	3	3
ENSG00000234389	02-Medium	0.39	7.29	G2	C2	—	—	—	32	85
NFKBIL1	02-Medium	0.39	5.50	G2	C2	—	—	4 cells — complete matches	101	243
LST1	02-Medium	0.39	6.10	G2	C2	granulocyte (L1), macrophage (L1), monocyte (L1), MAC.MDM (L1S), MONO.CD16 (L1S), ILC2.activated (L2), MAC.MDM.inflammatory_phagocytic (L2), MONO.CD14.baseline (L2)	T_cell (Tier: specific) MAC.alveolar (Tier: specific) T.CD4_Th17 (Tier: specific) innate_lymphoid_cell_2 (Tier: relevant) T.MAIT (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	106 cells — complete matches	183	440
ENSG00000254975	02-Medium	0.39	14.11	G1	C2	—	—	—	1	1
ENSG00000307907	02-Medium	0.38	5.43	G1	C2	—	—	—	489	1,000
ENSG00000294275	02-Medium	0.38	8.83	G1	C2	—	—	—	5	8
GBF1	02-Medium	0.38	6.95	G1	C2	—	—	EC.heart_remodeling.remodeling_secretory (L2), EPI.salivary_serous_acinar.quiescent (L2)	33	38
IL1R1-AS1	02-Medium	0.38	8.72	G1	C2	—	—	—	19	32
MCCD1	02-Medium	0.38	4.67	G2	C2	—	—	—	35	113
ENSG00000298396	02-Medium	0.37	5.24	G2	C1	—	—	—	295	527
LINC02129	02-Medium	0.37	8.14	G1	C2	—	—	—	3	8
HLA-DRB5	02-Medium	0.37	4.18	G2	C2	EC.venous.baseline (L2), EPI.endocervical_secretory.secretory_translocon (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MG.phagocytic_APC (L2), NK.adaptive_classII_inhibitory (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	B.germinal_center (Tier: specific) MAC.alveolar (Tier: specific) EC.venous.activated (Tier: specific) DC.mig (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD4_Treg (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant)	193 cells — complete matches	364	756
WBP1L	02-Medium	0.37	6.57	G1	C2	—	innate_lymphoid_cell_2 (Tier: relevant)	11 cells — complete matches	23	66
ENSG00000287771	02-Medium	0.36	7.48	G1	C2	—	—	—	20	37
LINC01127	02-Medium	0.35	8.18	G2	C2	—	innate_lymphoid_cell_2 (Tier: relevant)	17 cells — complete matches	17	36
ENSG00000304079	02-Medium	0.35	6.89	G1	C2	—	—	—	17	27
ELOVL3	02-Medium	0.35	4.08	G1	C2	—	T.CD8_Tcm.effector_bias (Tier: relevant)	13 cells — complete matches	32	43
LINC02571	02-Medium	0.34	4.59	G2	C1	—	—	—	0	1
ENSG00000272203	02-Medium	0.34	6.99	G2	C2	—	—	—	19	31
HLA-DRB1	02-Medium	0.34	5.50	G1	C2	EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), FIB.reticular.immune_interface (L2), MAC.resident_cardiac.antigen_presenting (L2), MAC.resident_repair.antigen_presenting (L2), MG.phagocytic_APC (L2), MONO.CD14.APC_like (L2), NK.adaptive_axis_baseline (L2), NK.adaptive_biosynthetic_primed (L2), NK.adaptive_classII_inhibitory (L2), NK.adaptive_immature_precursor (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Tem.cytotoxic_effector (L2), T.CD4_Tfh.effector_migratory (L2), T.CD4_Th17.cytotoxic (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_Trm.cytotoxic_effector (L2), T.CD4_transitional.APC_interacting (L2), T.CD4_transitional.primed_cytotoxic (L2), T.CD8_Trm.dendritic_recruiter (L2), T.CD8_transitional.APC_like (L2), T.MAIT.cytotoxic (L2)	B.germinal_center (Tier: specific) MAC.alveolar (Tier: specific) EC.venous.activated (Tier: specific) DC.mig (Tier: relevant) T.CD4_Tem (Tier: relevant) T.CD4_transitional (Tier: relevant) T.CD4_Treg (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant) MAC.alveolar.capillary_interacting (Tier: relevant) MAC.alveolar.inflammatory (Tier: relevant) MAC.alveolar.lipid_autophagy (Tier: relevant) MAC.alveolar.scavenging_endocytic (Tier: relevant) MAC.alveolar.stress_metabolic (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant)	203 cells — complete matches	565	1,192
ARL3	02-Medium	0.34	7.08	G1	C2	—	T.CD4_Trm.helper_like (Tier: relevant)	6 cells — complete matches	1	3
PPP1R3B-DT	02-Medium	0.34	5.12	G2	C2	—	—	—	112	460
ENSG00000294669	02-Medium	0.34	4.37	G1	C2	—	—	—	12	19
TH2LCRR	02-Medium	0.34	5.59	G2	C2	—	innate_lymphoid_cell_2 (Tier: relevant)	8 cells — complete matches	0	0
CIITA	02-Medium	0.34	1.76	G1	C2	MAC.resident_repair.stress_iron (L2)	B.germinal_center (Tier: specific) DC.mig (Tier: relevant) B.germinal_center.LZ_memory_precursor (Tier: relevant)	84 cells — complete matches	24	42
ENSG00000304559	02-Medium	0.33	3.80	G2	C2	—	—	—	337	717
SHROOM1	02-Medium	0.33	6.25	G2	C2	—	—	16 cells — complete matches	38	101
TRIM8-DT	02-Medium	0.33	8.58	G2	C2	—	—	—	16	42
SLC9A2	02-Medium	0.33	4.79	G2	C2	—	—	29 cells — complete matches	26	79
ENSG00000294651	02-Medium	0.32	5.44	G1	C2	—	—	—	14	25
RELA-DT	02-Medium	0.31	4.87	G2	C2	—	—	—	68	258
LY6G5B	02-Medium	0.30	2.66	G2	C2	—	T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	26 cells — complete matches	11	17
ENSG00000294323	02-Medium	0.29	2.08	G2	C2	—	—	—	1	2
IL33	02-Medium	0.29	3.75	G2	C2	EC.liver_sinusoidal.hypoxia_metabolic (L2), EPI.salivary_intercalated_defense.basal_EMT (L2), EPI.salivary_myoepithelial.baseline (L2), EPI.skin_sweat_duct_keratinocyte.signal_gate (L2), EPI.thymic_medullary.canonical_alarmin (L2), FIB.reticular.stromal_niche (L2)	EC.venous.activated (Tier: specific)	76 cells — complete matches	1	2
KLF3	02-Medium	0.29	9.78	G2	C2	PERI.angiocrine (L2), T.CD4_Trm.central_like (L2), THYMO.DN_preTCR (L2)	—	B.age_associated.migratory (L2), PC.IgG_systemic.interacting (L2)	13	41
ENSG00000305095	02-Medium	0.29	3.34	G2	C2	—	—	—	23	73
RGPD3	02-Medium	0.27	1.95	G2	C2	—	—	EC.heart_remodeling (L1S), EC.heart_remodeling.activated_acute (L2)	16	50
PSORS1C1	02-Medium	0.27	6.48	G2	C2	—	—	26 cells — complete matches	152	355
SOCS1	02-Medium	0.26	6.92	G2	C2	HPC.MPP_activated (L2)	T.CD4_Tcm (Tier: specific) T.CD4_Trm (Tier: specific) NK.cytokine_tissue_activation (Tier: specific) NK.cytokine_tissue_resident (Tier: specific) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.Tfh_like (Tier: relevant)	38 cells — complete matches	7	11
OVOL1-AS1	02-Medium	0.26	8.40	G2	C2	—	—	4 cells — complete matches	1	1
PPP1R3B	02-Medium	0.25	4.22	G2	C2	—	T.CD8_Tcm (Tier: specific) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	29 cells — complete matches	68	378
RAPGEF6	02-Medium	0.25	1.79	G2	C2	—	T.CD4_Tcm.Th2_like (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant)	10 cells — complete matches	4	2
ENSG00000263033	02-Medium	0.25	6.49	G2	C2	—	—	—	6	9
FAM66A	02-Medium	0.25	5.15	G2	C2	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling (L2)	T_cell (Tier: specific) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.Tfh_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	20 cells — complete matches	95	498
ENSG00000299066	02-Medium	0.25	1.28	G2	C2	—	—	—	4	1
Y_RNA.380	02-Medium	0.24	3.35	G2	C2	—	—	—	0	0
CLEC16A	02-Medium	0.24	5.78	G2	C2	—	T.CD4_transitional.tissue_enagement (Tier: relevant)	14 cells — complete matches	17	24
ENSG00000306976	02-Medium	0.24	6.39	G2	C2	—	—	—	5	5
FAM86B2	02-Medium	0.24	3.84	G2	C2	—	T.CD4_Tcm.Th2_like (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant)	17 cells — complete matches	45	113
ENSG00000262020	02-Medium	0.23	6.22	G2	C2	—	—	—	1	1
ERI1	02-Medium	0.22	3.79	G2	C2	—	T.CD4_transitional (Tier: relevant) T.CD4_Treg (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_Trm.helper_like (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant)	25 cells — complete matches	61	289
ENSG00000298127	02-Medium	0.21	3.48	G2	C2	—	—	—	12	26
ENSG00000273217	02-Medium	0.18	0.88	G2	C2	—	—	—	4	1
FNIP1	02-Medium	0.18	0.79	G2	C2	—	—	7 cells — complete matches	4	1
ENSG00000279584	02-Medium	0.16	0.83	G2	C2	—	—	—	4	1
ENSG00000299814	02-Medium	0.16	0.83	G2	C2	—	—	—	4	1
ENSG00000281938	02-Medium	0.16	1.28	G2	C2	—	—	—	5	2
ACSL6	02-Medium	0.16	1.21	G2	C2	—	T.CD4_Tcm (Tier: specific) T.CD8_Tcm (Tier: specific) T.CD4_naive.mature_mitoprot (Tier: specific) T.CD4_naive.neddylation (Tier: specific) T.CD4_Tem.long_term_memory (Tier: specific) T.CD4_Tem (Tier: relevant) T.CD4_Tcm.effector_like (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD4_Tcm.Th2_like (Tier: relevant) T.CD4_transitional.baseline (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant) T.CD4_Trm.metal_stress (Tier: relevant) T.CD8_Tcm.effector_bias (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant) T.MAIT.vesicle (Tier: relevant)	59 cells — complete matches	5	2
SLC22A5	02-Medium	0.15	2.61	G2	C2	—	T.CD4_transitional.tissue_enagement (Tier: relevant)	13 cells — complete matches	376	507
MEIKIN	02-Medium	0.14	0.64	G2	C2	—	DC.mig (Tier: relevant)	48 cells — complete matches	7	26

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.