Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000064 · All tissues

All influenza: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Influenza

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	haematopoietic_progenitor_cell	7.52	Significant	0.02	1.20	Specific	262	502
2	B_cell	5.20	Nominal	2.56e-18	1.20	Other	356	694
3	mesothelial_cell	4.90	Nominal	0.46	1.16	Other	6	36
4	hepatocyte	4.84	Nominal	6.63e-43	1.31	Other	1,515	3,822
5	induced_pluripotent_stem_cell	2.98	Nonsignificant	2.43e-06	1.10	Other	0	0
6	epithelial_cell	2.82	Nonsignificant	1.36e-18	1.13	Other	24	47
7	cardiomyocyte	2.27	Nonsignificant	2.81e-03	1.08	Other	533	2,045
8	thymocyte	2.23	Nonsignificant	1.00	0.98	Other	168	512
9	platelet	1.96	Nonsignificant	—	0.62	Other	85	104
10	endothelial_cell	1.96	Nonsignificant	1.00	0.97	Other	373	974
11	dendritic_cell	1.61	Nonsignificant	1.00	0.98	Other	496	724
12	microglia	1.51	Nonsignificant	1.00	1.04	Other	61	129
13	skeletal_muscle_cell	0.87	Nonsignificant	1.00	0.87	Other	944	2,600
14	monocyte	0.57	Nonsignificant	1.00	0.85	Other	2,176	3,871
15	neuron	0.55	Nonsignificant	1.00	0.77	Other	330	1,328
16	oligodendrocyte_precursor_cell	0.50	Nonsignificant	1.00	0.86	Other	461	1,454
17	macrophage	0.40	Nonsignificant	1.00	0.77	Other	813	1,732
18	astrocyte	0.28	Nonsignificant	1.00	0.72	Other	256	1,203
19	innate_lymphoid_cell_2	0.18	Nonsignificant	1.00	0.74	Other	3	8
20	melanocyte	0.18	Nonsignificant	1.00	0.70	Other	97	309
21	granulocyte	0.18	Nonsignificant	1.00	0.75	Other	5	6
22	pericyte	0.07	Nonsignificant	1.00	0.64	Other	128	517
23	plasma_cell	0.06	Nonsignificant	1.00	0.61	Other	17	24
24	granulosa_cell	0.06	Nonsignificant	1.00	0.63	Other	293	670
25	smooth_muscle_cell	0.04	Nonsignificant	1.00	0.59	Other	27	139
26	chondrocyte	0.02	Nonsignificant	1.00	0.63	Other	548	1,069
27	natural_killer_cell	0.02	Nonsignificant	1.00	0.60	Other	1,204	2,052
28	T_cell	0.02	Nonsignificant	1.00	0.40	Other	470	959
29	muscle_stem_cell	0.01	Nonsignificant	1.00	0.51	Other	7	27
30	fibroblast	9.71e-03	Nonsignificant	1.00	0.50	Other	184	826
31	adipose_stem_and_progenitor_cell	6.76e-03	Nonsignificant	1.00	0.54	Other	327	954
32	schwann_cell	3.62e-03	Nonsignificant	1.00	0.42	Other	10	57
33	adipocyte	1.13e-04	Nonsignificant	1.00	0.37	Other	33	111
34	oligodendrocyte	4.44e-05	Nonsignificant	1.00	0.59	Other	385	1,507

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_appendage_keratinocyte	18.42	Significant	1.15e-04	1.55	Specific	87	222
2	EPI.skin_hair_follicle_companion	14.31	Significant	—	1.73	Relevant	8	12
3	EPI.skin_sweat_duct_keratinocyte	12.93	Significant	0.27	1.32	Relevant	146	301
4	HEP.periportal_metabolic	12.64	Significant	3.00e-50	1.57	Specific	1,750	4,427
5	EPI.pancreatic_ductal_mucinous	12.64	Significant	0.04	1.42	Relevant	219	430
6	EPI.skin_keratinocyte_proliferating	9.56	Significant	0.43	1.26	Relevant	47	76
7	EC.heart_remodeling	9.36	Significant	6.52e-31	1.68	Specific	569	1,594
8	EPI.skin_interfollicular_spinous	9.23	Significant	1.15e-04	1.46	Specific	260	563
9	EPI.skin_follicular_keratinizing	8.62	Significant	0.33	1.29	Relevant	30	81
10	EPI.pancreatic_ductal_perivascular	8.32	Significant	0.33	1.27	Relevant	4	30
11	HPC.haematopoietic_progenitor_cell	7.52	Significant	—	—	Relevant	211	370
12	EPI.pancreatic_ductal_bicarbonate	7.23	Significant	0.06	1.25	Relevant	131	548
13	B.memory	6.35	Significant	5.59e-05	1.50	Specific	442	882
14	EPI.renal_distal_tubule	5.70	Significant	0.78	1.10	Other	133	361
15	EPI.ileal_bile_transport	5.60	Significant	0.37	1.24	Relevant	61	93
16	EPI.ileal_enterocyte_crypt	5.52	Significant	0.33	1.19	Other	67	113
17	EPI.thymic_cortical	5.07	Nominal	0.33	1.28	Other	442	824
18	MESO.mesothelial_cell	4.90	Nominal	—	—	Other	2	18
19	B.naive	4.45	Nominal	1.00	0.57	Other	307	595
20	EPI.renal_proximal_tubule	4.01	Nominal	0.33	1.25	Other	525	806
21	EPI.cervical_suprabasal	3.87	Nominal	—	0.61	Other	14	50
22	B.age_associated	3.67	Nominal	1.00	0.65	Other	207	350
23	DC.pDC	3.43	Nominal	1.24e-03	1.51	Other	496	1,028
24	EPI.pancreatic_ductal_progenitor	3.37	Nominal	0.78	1.07	Other	234	873
25	EPI.skin_keratinocyte_basal	3.32	Nominal	—	0.63	Other	13	26
26	EPI.renal_thick_ascending_limb	3.27	Nominal	0.64	1.07	Other	453	1,153
27	EPI.bile_duct_cholangiocyte	3.18	Nominal	0.78	1.13	Other	37	60
28	EPI.renal_intercalated_cell_type_A	3.13	Nominal	1.00	0.90	Other	67	142
29	IPSC.induced_pluripotent_stem_cell	2.98	Nonsignificant	—	—	Other	0	0
30	EPI.ileal_enterocyte_absorptive	2.86	Nonsignificant	1.00	0.99	Other	118	338
31	EPI.thymic_medullary	2.72	Nonsignificant	1.00	0.94	Other	26	133
32	EPI.colonic_enteroendocrine	2.59	Nonsignificant	—	0.27	Other	1	1
33	EPI.colonocyte	2.37	Nonsignificant	1.00	0.79	Other	294	815
34	CM.cardiomyocyte	2.27	Nonsignificant	—	—	Other	524	2,032
35	EPI.renal_intercalated_cell_type_B	2.24	Nonsignificant	—	0.38	Other	6	7
36	THYMO.thymocyte	2.23	Nonsignificant	—	—	Other	163	495
37	MAC.kupffer	2.22	Nonsignificant	0.12	1.22	Other	189	530
38	EPI.intrahepatic_cholangiocyte_transport	2.20	Nonsignificant	—	0.30	Other	12	42
39	EPI.salivary_mucous_acinar	2.13	Nonsignificant	1.00	0.91	Other	639	1,189
40	EPI.extrahepatic_cholangiocyte	2.04	Nonsignificant	—	0.25	Other	37	71
41	EPI.skin_hair_follicle_bulge	2.01	Nonsignificant	1.00	0.81	Other	51	178
42	PLAT.platelet	1.96	Nonsignificant	—	0.00	Other	38	53
43	EPI.salivary_duct_ion_transport	1.77	Nonsignificant	1.00	0.79	Other	5	11
44	EPI.endocervical_secretory	1.65	Nonsignificant	—	0.28	Other	0	0
45	MG.microglia	1.51	Nonsignificant	—	—	Other	49	0
46	EC.venous	1.50	Nonsignificant	1.00	0.90	Other	516	1,387
47	EPI.intrahepatic_cholangiocyte_defense	1.47	Nonsignificant	—	0.14	Other	8	13
48	EPI.renal_principal_cell	1.39	Nonsignificant	1.00	0.74	Other	207	403
49	DC.cDC2	1.29	Nonsignificant	1.00	0.48	Other	1,189	1,793
50	DC.cDC1	1.26	Nonsignificant	1.00	0.78	Other	55	112
51	SKM.type_2_fast	1.22	Nonsignificant	1.87e-33	3.03	Other	972	2,639
52	EPI.hepatic_ductular_cholangiocyte	1.17	Nonsignificant	1.00	0.65	Other	83	243
53	EPI.skin_keratinocyte_progenitor	1.14	Nonsignificant	—	0.00	Other	0	3
54	EPI.ileal_goblet	1.13	Nonsignificant	1.00	0.73	Other	181	432
55	EPI.ectocervical_granular	1.13	Nonsignificant	—	0.00	Other	11	23
56	MAC.resident_cardiac	1.12	Nonsignificant	1.97e-05	1.30	Other	485	1,074
57	EC.arterial	1.10	Nonsignificant	1.00	0.74	Other	356	885
58	EPI.colonic_tuft	1.08	Nonsignificant	—	0.03	Other	7	24
59	EPI.gastric_foveolar	0.97	Nonsignificant	—	0.00	Other	0	0
60	EPI.skin_sebaceous_duct_luminal	0.96	Nonsignificant	1.00	0.62	Other	100	249
61	B.germinal_center	0.92	Nonsignificant	1.00	0.16	Other	233	655
62	NEU.EXC_IT	0.90	Nonsignificant	3.58e-08	1.56	Other	411	192
63	MONO.CD14	0.60	Nonsignificant	2.17e-06	1.42	Other	2,294	4,139
64	EPI.tracheal_suprabasal	0.56	Nonsignificant	1.00	0.51	Other	29	56
65	EPI.lung_multiciliated	0.55	Nonsignificant	1.00	0.57	Other	16	49
66	EPI.esophageal_suprabasal	0.52	Nonsignificant	1.00	0.59	Other	158	404
67	HEP.pericentral_lipoprotein	0.52	Nonsignificant	—	0.11	Other	0	0
68	NEU.EXC_CT	0.51	Nonsignificant	1.00	1.02	Other	362	384
69	EPI.esophageal_basal	0.51	Nonsignificant	1.00	0.57	Other	4	10
70	OPC.oligodendrocyte_precursor_cell	0.50	Nonsignificant	—	—	Other	413	1,269
71	EPI.salivary_duct_excretory	0.50	Nonsignificant	1.00	0.57	Other	85	180
72	HEP.acute_phase	0.45	Nonsignificant	1.00	0.51	Other	1,441	3,641
73	EPI.alveolar_type_1	0.42	Nonsignificant	1.00	0.57	Other	26	101
74	MONO.CD16	0.42	Nonsignificant	1.00	0.73	Other	1,304	1,835
75	SKM.type_1_slow	0.39	Nonsignificant	1.00	0.06	Other	923	2,478
76	EC.liver_sinusoidal	0.36	Nonsignificant	1.00	0.50	Other	1,083	1,925
77	EC.capillary	0.34	Nonsignificant	1.00	0.05	Other	514	1,635
78	EC.lymphatic	0.32	Nonsignificant	1.00	0.41	Other	630	998
79	EPI.renal_immature_ureteric_bud	0.30	Nonsignificant	1.00	0.50	Other	217	569
80	ASTRO.astrocyte	0.28	Nonsignificant	—	—	Other	228	1,111
81	MAC.resident_iron	0.25	Nonsignificant	1.00	0.80	Other	16	21
82	T.CD4_Th2	0.24	Nonsignificant	—	1.87	Other	1	2
83	EPI.lung_club_secretory	0.23	Nonsignificant	1.00	0.48	Other	5	14
84	MAC.MDM	0.23	Nonsignificant	1.00	0.95	Other	623	986
85	GRANU.MAST	0.19	Nonsignificant	0.33	1.54	Other	5	6
86	NEU.EXC_SYT2	0.19	Nonsignificant	—	0.00	Other	40	77
87	T.CD4_Tfh	0.18	Nonsignificant	0.06	1.16	Other	47	45
88	ILC2.innate_lymphoid_cell_2	0.18	Nonsignificant	—	—	Other	2	0
89	MEL.melanocyte	0.18	Nonsignificant	—	—	Other	79	242
90	FIB.suburothelial	0.18	Nonsignificant	0.25	1.19	Other	122	432
91	EPI.salivary_serous_acinar	0.16	Nonsignificant	1.00	0.70	Other	233	531
92	MAC.resident_repair	0.16	Nonsignificant	1.00	0.78	Other	796	1,426
93	GRANU.neutrophil	0.15	Nonsignificant	0.95	0.13	Other	1,235	2,649
94	HEP.canalicular_transport	0.14	Nonsignificant	1.00	5.33e-03	Other	1,290	3,434
95	PC.IgG_systemic	0.13	Nonsignificant	0.18	1.15	Other	41	60
96	MAC.LAM	0.13	Nonsignificant	1.00	0.76	Other	914	2,064
97	T.CD4_Treg	0.12	Nonsignificant	0.06	1.14	Other	244	511
98	MAC.proliferating	0.12	Nonsignificant	1.00	0.70	Other	87	253
99	EPI.tracheal_basal	0.12	Nonsignificant	1.00	0.45	Other	398	1,120
100	DC.mig	0.11	Nonsignificant	—	0.00	Other	89	156
101	NEU.INH_LAMP5	0.09	Nonsignificant	1.00	0.38	Other	263	532
102	PERI.pericyte	0.07	Nonsignificant	—	—	Other	117	0
103	FIB.perivascular_interface	0.06	Nonsignificant	1.00	1.15	Other	0	0
104	NEU.INH_VIP	0.06	Nonsignificant	1.00	0.22	Other	241	366
105	GRNLSA.granulosa_cell	0.06	Nonsignificant	—	—	Other	257	0
106	FIB.barrier_purinergic	0.06	Nonsignificant	—	1.47	Other	1	3
107	FIB.lung_alveolar	0.06	Nonsignificant	—	1.66	Other	6	15
108	PC.IgA_muocsal	0.05	Nonsignificant	0.99	0.72	Other	18	31
109	EPI.pancreatic_islet	0.05	Nonsignificant	1.00	0.40	Other	52	132
110	MAC.microglia_like	0.04	Nonsignificant	1.00	0.83	Other	124	179
111	SMC.smooth_muscle_cell	0.04	Nonsignificant	—	—	Other	20	101
112	EPI.tracheal_submucosal_gland	0.03	Nonsignificant	—	0.00	Other	0	0
113	T.CD4_naive	0.03	Nonsignificant	0.06	1.05	Other	399	866
114	EPI.alveolar_type_2	0.03	Nonsignificant	1.00	0.39	Other	813	1,853
115	NEU.INH_PVALB	0.02	Nonsignificant	1.00	0.04	Other	193	183
116	CHOND.chondrocyte	0.02	Nonsignificant	—	—	Other	519	730
117	NK.natural_killer_cell	0.02	Nonsignificant	—	—	Other	1,204	2,045
118	EPI.salivary_intercalated_defense	0.02	Nonsignificant	1.00	0.42	Other	81	161
119	MAC.alveolar	0.02	Nonsignificant	0.11	1.18	Other	1,432	3,122
120	T.CD4_transitional	0.02	Nonsignificant	1.00	1.00	Other	48	110
121	T.CD4_Tcm	0.02	Nonsignificant	1.00	0.96	Other	494	988
122	MUSC.muscle_stem_cell	0.01	Nonsignificant	—	—	Other	4	18
123	T.CD4_Trm	0.01	Nonsignificant	0.61	1.05	Other	176	363
124	T.CD8_naive	0.01	Nonsignificant	1.00	0.88	Other	317	708
125	FIB.hepatic_stellate_cell	9.64e-03	Nonsignificant	—	1.16	Other	64	252
126	FIB.neurolectin_mucosa	8.86e-03	Nonsignificant	1.00	0.98	Other	133	394
127	ASPC.adipose_stem_and_progenitor_cell	6.76e-03	Nonsignificant	—	—	Other	324	930
128	EPI.pancreatic_acinar	6.69e-03	Nonsignificant	1.00	0.24	Other	429	1,475
129	T.CD8_Tcm	6.52e-03	Nonsignificant	1.00	0.89	Other	460	926
130	FIB.skin_neurosecretory	6.12e-03	Nonsignificant	—	1.02	Other	0	0
131	T.CD4_Th17	5.55e-03	Nonsignificant	0.66	1.06	Other	421	794
132	FIB.skin_sheath	5.35e-03	Nonsignificant	1.00	0.93	Other	49	118
133	T.CD8_Tem	5.01e-03	Nonsignificant	1.00	0.96	Other	1,083	1,857
134	T.CD8_Trm	4.57e-03	Nonsignificant	0.66	1.03	Other	211	346
135	SCHWN.schwann_cell	3.62e-03	Nonsignificant	—	—	Other	7	33
136	T.CD4_Tem	2.59e-03	Nonsignificant	1.00	0.83	Other	365	697
137	T.CD8_transitional	2.44e-03	Nonsignificant	1.00	0.98	Other	497	932
138	FIB.skin_tenogenic	2.31e-03	Nonsignificant	—	0.59	Other	108	227
139	FIB.reticular	2.02e-03	Nonsignificant	1.00	0.85	Other	19	87
140	FIB.interstitial	1.68e-03	Nonsignificant	1.00	0.83	Other	288	940
141	FIB.adventitial	1.49e-03	Nonsignificant	1.00	0.67	Other	268	1,447
142	NEU.EXC_NTNG1	1.45e-03	Nonsignificant	—	0.00	Other	0	0
143	FIB.tracheal_subepithelial	1.41e-03	Nonsignificant	—	0.57	Other	0	0
144	T.MAIT	4.59e-04	Nonsignificant	1.00	0.88	Other	469	855
145	FIB.barrier_secretory	2.03e-04	Nonsignificant	1.00	0.93	Other	81	228
146	T.CD4_cytotoxic	1.68e-04	Nonsignificant	1.00	0.67	Other	855	1,493
147	EPI.salivary_myoepithelial	1.39e-04	Nonsignificant	1.00	0.21	Other	191	714
148	FIB.transitioning	1.33e-04	Nonsignificant	1.00	0.94	Other	172	497
149	ADIPO.adipocyte	1.13e-04	Nonsignificant	—	—	Other	20	62
150	T.gamma_delta	4.50e-05	Nonsignificant	1.00	0.47	Other	588	1,078
151	OLG.oligodendrocyte	4.44e-05	Nonsignificant	—	—	Other	384	1,397
152	FIB.skin_papillary	2.48e-05	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_appendage_keratinocyte.transit_amplifying	47.45	Significant	—	1.11	Specific	109	358
2	EPI.skin_hair_follicle_companion.gap_junction_contractile	28.91	Significant	—	0.97	—	0	0
3	EPI.skin_sweat_duct_keratinocyte.proliferative_S	27.35	Significant	—	1.52	—	0	0
4	HEP.periportal_metabolic.stress_chaperone	20.11	Significant	—	1.08	Relevant	66	128
5	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	19.60	Significant	—	0.69	Relevant	0	0
6	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	18.68	Significant	3.30e-06	2.19	Specific	40	191
7	HEP.periportal_metabolic.xenobiotic_detox	17.27	Significant	1.24e-04	2.15	—	1,440	139
8	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	16.73	Significant	0.03	1.75	Specific	449	1,034
9	HEP.periportal_metabolic.canonical_urea_cycle	14.95	Significant	0.02	1.66	—	1,464	269
10	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	14.76	Significant	0.86	1.08	—	33	34
11	EC.heart_remodeling.angiocrine	14.58	Significant	2.72e-08	2.36	Specific	182	525
12	EC.heart_remodeling.translation_boost	14.46	Significant	—	0.87	—	0	0
13	EPI.skin_sweat_duct_keratinocyte.signal_gate	14.41	Significant	—	0.35	—	43	26
14	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	13.87	Significant	—	0.10	Relevant	0	0
15	EPI.skin_keratinocyte_proliferating.anchor_remodel	13.73	Significant	—	0.55	—	0	0
16	EPI.renal_distal_tubule.ciliated_remodelling	13.48	Significant	—	1.04	Relevant	0	0
17	HEP.periportal_metabolic.urea_onecarbon_secretory	13.12	Significant	1.00	0.99	Specific	1,332	3,053
18	EPI.skin_interfollicular_spinous.proliferative	12.85	Significant	—	1.13	—	0	0
19	HPC.MEP	12.53	Significant	0.14	1.53	Relevant	599	1,195
20	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	12.30	Significant	0.86	0.48	Relevant	7	16
21	EPI.skin_interfollicular_spinous.transition_basal	12.12	Significant	0.09	1.89	—	100	127
22	EC.heart_remodeling.activated_acute	12.07	Significant	0.37	1.43	Relevant	102	186
23	HEP.periportal_metabolic.inflammatory_activated	11.52	Significant	1.00	0.56	Specific	712	1,610
24	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	11.52	Significant	—	0.66	Relevant	0	0
25	HPC.LMPP	10.26	Significant	0.14	1.40	—	65	31
26	EPI.skin_interfollicular_spinous.early_differentiation	9.73	Significant	0.71	1.02	—	89	19
27	IPSC.stress	9.55	Significant	2.82e-04	1.83	Relevant	0	0
28	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	9.52	Significant	—	0.00	—	39	82
29	B.memory.pDC_imprint	9.25	Significant	0.04	1.67	—	157	103
30	THYMO.proliferative_G2M	9.19	Significant	—	2.25	Specific	164	413
31	EPI.skin_follicular_keratinizing.transit_amplifying	9.03	Significant	—	0.11	Relevant	21	49
32	EPI.colonocyte.ionocyte_BEST4	8.97	Significant	4.48e-05	2.03	Specific	103	188
33	EPI.skin_follicular_keratinizing.upper_infundibulum	8.92	Significant	—	0.05	—	8	2
34	EPI.skin_interfollicular_spinous.inflammatory	8.86	Significant	—	0.00	—	0	0
35	EPI.pancreatic_ductal_perivascular.baseline	8.75	Significant	0.26	1.33	Relevant	1	5
36	EPI.skin_keratinocyte_proliferating.early_spinous_transition	8.60	Significant	—	0.00	Relevant	135	290
37	EPI.skin_interfollicular_spinous.baseline	8.36	Significant	0.87	0.49	—	35	3
38	MESO.activated_stress	8.27	Significant	—	0.44	Relevant	0	0
39	EPI.colonocyte.distal_absorptive	8.18	Significant	—	1.73	Relevant	0	0
40	HEP.periportal_metabolic.apolipoprotein_secretory	8.13	Significant	1.00	0.31	Relevant	43	110
41	EPI.renal_distal_tubule.ion_transport	7.96	Significant	—	0.40	Relevant	0	0
42	EPI.ileal_enterocyte_crypt.proliferative_G2M	7.95	Significant	—	0.39	Relevant	19	54
43	EPI.skin_interfollicular_spinous.stress_oxidative	7.85	Significant	—	0.00	—	0	0
44	EPI.pancreatic_ductal_perivascular.protective_antioxidant	7.64	Significant	—	0.00	Relevant	11	69
45	EPI.skin_hair_follicle_companion.activated_migratory	7.61	Significant	—	0.00	—	0	0
46	B.memory.baseline	7.53	Significant	6.56e-05	1.77	—	472	99
47	EC.heart_remodeling.remodeling_stalk	7.43	Significant	1.00	0.60	Relevant	33	111
48	EPI.skin_follicular_keratinizing.root_infundibulum	7.42	Significant	—	0.00	—	0	0
49	EPI.ileal_enterocyte_crypt.proliferative_S	7.37	Significant	0.29	1.49	Relevant	4	2
50	HEP.periportal_metabolic.acute_phase_barrier	7.35	Significant	1.00	0.16	—	533	138
51	EPI.skin_interfollicular_spinous.stress_UPR	7.34	Significant	—	0.00	—	0	0
52	HPC.MPP_IEG	7.29	Significant	0.82	0.90	—	45	46
53	EPI.pancreatic_ductal_bicarbonate.activated	7.24	Significant	0.79	1.04	—	10	7
54	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	7.05	Significant	—	0.00	—	0	0
55	EPI.pancreatic_ductal_bicarbonate.baseline	6.94	Significant	0.79	1.04	Relevant	11	42
56	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	6.82	Significant	—	0.00	Relevant	0	0
57	EPI.pancreatic_ductal_bicarbonate.stress	6.57	Significant	—	0.02	—	12	33
58	EPI.skin_sweat_duct_keratinocyte.repair	6.52	Significant	—	0.00	—	0	0
59	EPI.colonic_enteroendocrine.Lcell_peptide	6.51	Significant	—	0.97	Relevant	0	0
60	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	6.49	Significant	—	0.00	Other	0	0
61	EPI.renal_thick_ascending_limb.canonical_salt_transporter	6.48	Significant	0.05	1.43	Relevant	322	317
62	B.naive.receptor_recycle	6.41	Significant	0.58	1.21	Relevant	51	0
63	EPI.ileal_enterocyte_crypt.villus_transition	6.39	Significant	—	0.43	Relevant	7	10
64	EC.heart_remodeling.capillary_metabolic	6.35	Significant	1.00	0.61	Relevant	54	414
65	EPI.skin_keratinocyte_proliferating.detox_repair	6.31	Significant	—	0.00	Other	0	0
66	EC.heart_remodeling.remodeling_secretory	6.26	Significant	1.00	0.11	Other	605	1,341
67	EPI.renal_distal_tubule.repair	6.21	Significant	—	0.00	Other	34	102
68	EPI.thymic_cortical.Notch_interface	6.01	Significant	—	0.74	Relevant	82	137
69	EPI.pancreatic_ductal_progenitor.ciliated_transport	5.90	Significant	—	1.39	Relevant	105	368
70	EPI.skin_keratinocyte_basal.spinous_transition	5.87	Significant	—	0.97	Relevant	0	0
71	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	5.81	Significant	—	0.00	—	0	0
72	MESO.antiviral	5.81	Significant	—	0.31	Relevant	3	8
73	EPI.ileal_bile_transport.absorptive_xenobiotic	5.76	Significant	0.36	1.17	Relevant	11	12
74	IPSC.mesodermal_primed	5.74	Significant	0.03	1.59	Relevant	0	0
75	EPI.thymic_cortical.baseline	5.68	Significant	0.52	0.93	Relevant	185	386
76	B.naive.remodeling	5.65	Significant	0.58	1.20	Other	135	230
77	HPC.MPP_activated	5.55	Significant	—	0.00	—	0	0
78	EC.heart_remodeling.perivascular	5.53	Significant	1.00	0.43	Other	124	408
79	B.naive.purinergic	5.52	Significant	0.44	1.26	Other	384	820
80	EPI.renal_thick_ascending_limb.salt_sensing	5.39	Nominal	0.52	1.20	Other	73	103
81	EPI.ileal_bile_transport.detox_transcytosis	5.14	Nominal	—	0.00	Other	0	1
82	EPI.renal_intercalated_cell_type_A.PC_transitional	5.13	Nominal	—	0.35	Other	203	407
83	B.naive.baseline	5.07	Nominal	0.70	1.02	Other	10	13
84	PLAT.megakaryocytic	5.04	Nominal	—	0.97	Other	0	0
85	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	4.92	Nominal	—	0.00	Other	49	237
86	EPI.renal_distal_tubule.stress	4.91	Nominal	—	0.00	Other	0	0
87	B.memory.migratory	4.90	Nominal	1.00	0.71	Other	123	208
88	B.naive.antigen_presenting_ready	4.77	Nominal	0.70	1.09	Other	48	73
89	MAC.kupffer.fibrogenic	4.68	Nominal	—	0.80	Other	0	0
90	EPI.cervical_suprabasal.secretory_vesicle	4.67	Nominal	—	0.00	Other	0	0
91	EPI.pancreatic_ductal_bicarbonate.inflammatory	4.66	Nominal	1.00	0.60	Other	14	32
92	EPI.ileal_enterocyte_crypt.baseline	4.58	Nominal	0.73	1.01	Other	11	6
93	B.naive.proteostasis	4.54	Nominal	0.70	1.02	Other	49	69
94	B.naive.metabolic	4.47	Nominal	0.80	0.93	Other	50	79
95	IPSC.proliferative	4.43	Nominal	1.48e-09	1.71	Other	0	0
96	EPI.ileal_enterocyte_crypt.bile_transport	4.42	Nominal	0.93	0.46	Other	2	0
97	B.memory.activated	4.35	Nominal	1.00	0.34	Other	105	29
98	EPI.renal_proximal_tubule.onecarbon_peroxisome	4.25	Nominal	0.16	1.85	Other	58	89
99	B.age_associated.activated	4.24	Nominal	—	0.51	Other	18	22
100	MESO.baseline	4.24	Nominal	0.58	1.00	Other	0	6
101	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	4.00	Nominal	—	0.00	Other	0	0
102	B.age_associated.naive_transitional	3.93	Nominal	—	0.13	Other	0	0
103	EPI.bile_duct_cholangiocyte.secretory_mucin	3.90	Nominal	—	0.31	Other	7	12
104	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	3.88	Nominal	—	1.15	Other	0	0
105	DC.pDC.immature_metabolic	3.85	Nominal	0.10	1.97	Other	78	124
106	EPI.renal_proximal_tubule.detox_antioxidant	3.83	Nominal	0.92	0.31	Other	394	77
107	HEP.periportal_metabolic.stress_checkpoint	3.78	Nominal	1.00	0.00	Other	234	786
108	THYMO.DP_early	3.74	Nominal	1.22e-06	1.76	Other	326	313
109	MESO.activated_migratory	3.70	Nominal	—	0.00	Other	0	0
110	EC.venous.remodeling_stalk	3.62	Nominal	0.06	1.59	Other	559	566
111	EPI.skin_sweat_duct_keratinocyte.barrier	3.42	Nominal	—	0.00	Other	0	0
112	EPI.endocervical_secretory.squamous_barrier	3.39	Nominal	—	0.67	Other	0	0
113	IPSC.mesenchymal_primed	3.38	Nominal	0.24	1.18	Other	0	0
114	MESO.secretory_structural	3.35	Nominal	—	0.00	Other	0	0
115	EPI.skin_interfollicular_spinous.upper_lipid	3.35	Nominal	—	0.00	Other	6	6
116	DC.pDC.poised_migratory	3.28	Nominal	0.89	0.86	Other	54	95
117	THYMO.SP_CD4_naive	3.20	Nominal	0.36	1.28	Other	65	75
118	DC.pDC.baseline	3.15	Nominal	0.89	0.38	Other	88	123
119	EPI.pancreatic_ductal_progenitor.baseline	3.15	Nominal	0.25	1.28	Other	179	702
120	IPSC.stromal_primed	3.14	Nominal	1.00	0.83	Other	0	0
121	B.age_associated.migratory	3.11	Nominal	0.92	0.34	Other	2	2
122	EPI.thymic_medullary.stress_APC	3.11	Nominal	0.71	1.17	Other	2	4
123	EPI.thymic_cortical.secretory_remodeling	3.10	Nominal	—	0.00	Other	4	1
124	EPI.ileal_enterocyte_absorptive.villus_tip	3.10	Nominal	0.34	1.42	Other	4	3
125	EPI.cervical_suprabasal.inflammatory_repair	3.06	Nominal	—	0.00	Other	0	0
126	EPI.skin_keratinocyte_basal.transit_amplifying	3.06	Nominal	—	0.00	Other	0	0
127	EPI.thymic_medullary.hormone_xeno_barrier	3.00	Nominal	—	0.50	Other	0	8
128	MAC.kupffer.inflammatory	2.91	Nonsignificant	—	0.11	Other	7	4
129	HPC.GMP_inflammatory	2.90	Nonsignificant	1.00	0.14	Other	20	10
130	IPSC.axial_identity_primed	2.90	Nonsignificant	1.00	0.90	Other	0	0
131	THYMO.proliferative_S	2.88	Nonsignificant	0.36	1.27	Other	163	418
132	B.naive.activated	2.82	Nonsignificant	1.00	0.46	Other	77	127
133	CM.sarcomere_actin_interface	2.79	Nonsignificant	0.08	1.50	Other	450	78
134	DC.cDC1.homeostatic_inhibitory	2.78	Nonsignificant	—	1.21	Other	0	0
135	EPI.renal_thick_ascending_limb.cation_flux	2.77	Nonsignificant	1.00	0.76	Other	57	95
136	IPSC.neural_primed	2.75	Nonsignificant	1.00	0.94	Other	0	0
137	MAC.resident_cardiac.antigen_presenting	2.75	Nonsignificant	0.04	1.73	Other	52	27
138	EC.venous.quiescent_homeostatic	2.74	Nonsignificant	0.05	1.63	Other	456	360
139	CM.anti_inflammatory	2.71	Nonsignificant	0.29	1.38	Other	424	1,503
140	B.memory.preactivated	2.65	Nonsignificant	1.00	0.32	Other	173	174
141	EPI.ileal_enterocyte_absorptive.brush_border	2.63	Nonsignificant	0.92	0.41	Other	580	1,717
142	CM.osmoprotection	2.63	Nonsignificant	0.43	1.33	Other	34	57
143	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.62	Nonsignificant	—	0.42	Other	0	0
144	HPC.GMP_granulocytic	2.60	Nonsignificant	—	0.00	Other	3	3
145	CM.mito_proteostasis	2.58	Nonsignificant	1.00	1.02	Other	329	29
146	EPI.renal_intercalated_cell_type_A.acid_secretion	2.56	Nonsignificant	0.78	0.70	Other	12	6
147	EPI.thymic_medullary.canonical_alarmin	2.51	Nonsignificant	0.76	0.67	Other	8	17
148	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	2.50	Nonsignificant	—	1.15	Other	0	0
149	EPI.bile_duct_cholangiocyte.inflammatory_APC	2.50	Nonsignificant	—	0.00	Other	2	0
150	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.50	Nonsignificant	—	0.00	Other	0	0
151	MAC.kupffer.monocyte_like	2.49	Nonsignificant	—	0.58	Other	0	0
152	EPI.skin_hair_follicle_bulge.quiescent	2.45	Nonsignificant	0.06	1.67	Other	56	69
153	MAC.kupffer.tolerogenic	2.43	Nonsignificant	—	0.63	Other	45	49
154	IPSC.midbrain_primed	2.42	Nonsignificant	1.00	0.88	Other	0	0
155	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	2.39	Nonsignificant	—	1.32	Other	6	9
156	CM.oxidative_phospho	2.34	Nonsignificant	1.00	0.87	Other	266	792
157	DC.cDC2.adhesion_signaling	2.31	Nonsignificant	0.35	1.28	Other	35	9
158	EPI.renal_intercalated_cell_type_B.baseline	2.24	Nonsignificant	—	0.00	Other	3	1
159	EPI.pancreatic_ductal_progenitor.ADM_like	2.23	Nonsignificant	—	0.00	Other	0	0
160	EPI.salivary_serous_acinar.seromucous_like	2.22	Nonsignificant	—	2.10	Other	0	0
161	CM.baseline	2.18	Nonsignificant	1.00	0.83	Other	393	0
162	EPI.salivary_mucous_acinar.baseline	2.13	Nonsignificant	—	—	Other	394	683
163	EPI.colonocyte.junction_remodeling	2.06	Nonsignificant	0.95	1.09	Other	218	305
164	B.naive.restrained	2.05	Nonsignificant	1.00	0.45	Other	183	353
165	EPI.renal_principal_cell.injury_repair	2.02	Nonsignificant	0.18	1.60	Other	26	9
166	NEU.EXC_IT.callosal	1.98	Nonsignificant	3.01e-05	1.90	Other	286	119
167	EPI.ileal_enterocyte_crypt.secretory_precursor	1.95	Nonsignificant	—	0.00	Other	0	0
168	CM.translation_boost_RPS	1.91	Nonsignificant	1.00	0.61	Other	69	16
169	CM.translation_boost_RPL	1.90	Nonsignificant	1.00	0.53	Other	129	1
170	EPI.renal_principal_cell.activated_acute	1.87	Nonsignificant	0.17	1.76	Other	29	59
171	EPI.thymic_medullary.proliferative_APC	1.86	Nonsignificant	—	0.00	Other	0	0
172	EC.venous.activated	1.82	Nonsignificant	0.30	1.25	Other	247	752
173	EPI.skin_keratinocyte_basal.basement_anchoring	1.81	Nonsignificant	—	0.00	Other	0	0
174	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	1.78	Nonsignificant	1.00	0.00	Other	219	533
175	EPI.salivary_duct_ion_transport.baseline	1.77	Nonsignificant	—	—	Other	0	0
176	MG.expanding	1.75	Nonsignificant	0.38	1.34	Other	2	1
177	EPI.colonocyte.goblet_interface	1.70	Nonsignificant	—	0.05	Other	11	21
178	EPI.ectocervical_granular.proliferative_basal	1.67	Nonsignificant	—	1.15	Other	0	0
179	EPI.renal_thick_ascending_limb.remodeling	1.66	Nonsignificant	1.00	0.50	Other	152	92
180	EPI.esophageal_suprabasal.proliferative_S	1.65	Nonsignificant	—	1.22	Other	26	41
181	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.64	Nonsignificant	—	0.79	Other	0	0
182	DC.cDC2.antiviral	1.64	Nonsignificant	0.70	1.07	Other	100	37
183	EPI.salivary_serous_acinar.quiescent	1.62	Nonsignificant	0.18	1.13	Other	178	493
184	EC.arterial.metabolic	1.59	Nonsignificant	6.04e-03	1.73	Other	195	159
185	EC.venous.cardiac_structural	1.56	Nonsignificant	0.32	1.30	Other	102	229
186	MG.baseline	1.55	Nonsignificant	0.38	1.30	Other	16	5
187	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.55	Nonsignificant	—	0.42	Other	0	0
188	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.54	Nonsignificant	—	0.00	Other	0	0
189	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.53	Nonsignificant	—	0.00	Other	0	0
190	EPI.colonocyte.crypt_progenitor	1.53	Nonsignificant	0.95	0.57	Other	115	265
191	EC.arterial.elastic	1.52	Nonsignificant	0.21	1.34	Other	22	45
192	B.germinal_center.DZ_S_phase	1.50	Nonsignificant	—	1.13	Other	0	0
193	EPI.hepatic_ductular_cholangiocyte.stress	1.48	Nonsignificant	—	0.40	Other	0	0
194	SKM.type_2_fast.glycolytic_IIx_IIb	1.46	Nonsignificant	7.35e-05	2.56	Other	565	1,482
195	DC.cDC2.migratory	1.45	Nonsignificant	0.91	0.97	Other	185	39
196	EPI.ileal_goblet.inflammatory_mucin	1.42	Nonsignificant	0.04	2.03	Other	6	9
197	EPI.skin_sebaceous_duct_luminal.immune_interface	1.41	Nonsignificant	—	0.46	Other	0	0
198	EPI.extrahepatic_cholangiocyte.barrier_interface	1.41	Nonsignificant	—	0.00	Other	0	0
199	EC.capillary.angiogenic_tip	1.40	Nonsignificant	0.08	1.40	Other	186	218
200	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.39	Nonsignificant	—	0.00	Other	0	0
201	EPI.renal_distal_tubule.immune_modulatory	1.36	Nonsignificant	—	0.00	Other	0	0
202	EPI.skin_sebaceous_duct_luminal.detox_repair	1.33	Nonsignificant	0.37	1.34	Other	137	94
203	EPI.colonocyte.secretory_boost	1.33	Nonsignificant	0.95	0.56	Other	98	91
204	MG.phagocytic_APC	1.31	Nonsignificant	0.94	0.33	Other	25	8
205	DC.cDC2.monocyte_like	1.30	Nonsignificant	0.70	1.12	Other	1,285	791
206	EPI.ectocervical_granular.immune_interact	1.27	Nonsignificant	—	0.32	Other	0	0
207	MAC.resident_cardiac.inflammatory_reparative	1.26	Nonsignificant	0.16	1.55	Other	31	96
208	EPI.ileal_goblet.stress_metallothionein	1.23	Nonsignificant	—	0.12	Other	4	11
209	CM.mechano_activated	1.22	Nonsignificant	1.00	0.34	Other	205	134
210	EC.arterial.inflammatory	1.22	Nonsignificant	0.58	1.12	Other	63	50
211	EC.venous.baseline	1.20	Nonsignificant	1.00	0.51	Other	346	807
212	MONO.CD14.platelet_bound	1.18	Nonsignificant	0.03	1.44	Other	964	176
213	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.16	Nonsignificant	—	0.24	Other	0	0
214	MAC.kupffer.stress	1.14	Nonsignificant	0.90	0.45	Other	9	3
215	DC.cDC1.activated	1.14	Nonsignificant	—	0.00	Other	0	0
216	IPSC.mesendo_primed	1.14	Nonsignificant	1.00	0.17	Other	0	0
217	EPI.colonocyte.proximal_transport	1.13	Nonsignificant	0.95	0.56	Other	24	12
218	EPI.renal_principal_cell.inflammatory	1.11	Nonsignificant	0.98	0.78	Other	74	157
219	EC.arterial.homeostatic	1.11	Nonsignificant	0.73	0.97	Other	24	3
220	EPI.colonic_tuft.homeostatic	1.09	Nonsignificant	—	0.00	Other	0	0
221	SKM.type_2_fast.oxidative_IIa	1.08	Nonsignificant	1.00	0.00	Other	946	56
222	EPI.renal_principal_cell.intercalated_like	1.08	Nonsignificant	0.98	0.28	Other	63	66
223	EPI.colonic_tuft.activated	1.07	Nonsignificant	—	0.00	Other	0	0
224	EPI.ileal_goblet.immature	1.07	Nonsignificant	—	0.00	Other	0	0
225	EC.arterial.angiogenic_tip	1.06	Nonsignificant	—	0.00	Other	30	37
226	EPI.skin_hair_follicle_bulge.anagen_growth	1.05	Nonsignificant	—	0.00	Other	0	0
227	DC.cDC1.cross_presenting	1.04	Nonsignificant	—	0.00	Other	0	0
228	IPSC.canonical_pluripotent	1.03	Nonsignificant	1.00	0.14	Other	0	0
229	EC.arterial.arteriole_interface	1.03	Nonsignificant	0.58	1.08	Other	31	12
230	NEU.EXC_IT.guidance	1.02	Nonsignificant	1.00	1.07	Other	274	63
231	EPI.esophageal_suprabasal.proliferative_G2M	1.00	Nonsignificant	—	1.15	Other	0	0
232	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.00	Nonsignificant	—	0.00	Other	29	88
233	EPI.esophageal_suprabasal.proliferative_exit	0.99	Nonsignificant	—	0.85	Other	0	0
234	MONO.CD14.APC_like	0.99	Nonsignificant	1.93e-03	1.41	Other	1,686	2,493
235	EC.arterial.mito_contact	0.98	Nonsignificant	0.21	1.46	Other	14	5
236	THYMO.SP_CD8_naive	0.97	Nonsignificant	1.00	0.30	Other	297	177
237	EPI.gastric_foveolar.baseline	0.97	Nonsignificant	—	0.00	Other	0	0
238	MONO.CD16.platelet_bound	0.96	Nonsignificant	0.34	1.22	Other	372	508
239	DC.cDC2.tolerogenic_regulatory	0.93	Nonsignificant	1.00	0.75	Other	44	4
240	EPI.esophageal_suprabasal.basal_transitional	0.92	Nonsignificant	0.28	1.28	Other	44	67
241	EC.liver_sinusoidal.stress	0.92	Nonsignificant	—	0.89	Other	413	158
242	EPI.ileal_goblet.baseline	0.89	Nonsignificant	0.97	0.13	Other	16	2
243	THYMO.SP_CD8_transitional	0.88	Nonsignificant	1.00	0.25	Other	32	75
244	EC.liver_sinusoidal.secretory_lipoprotein	0.88	Nonsignificant	5.36e-03	1.45	Other	120	70
245	EPI.colonic_enteroendocrine.progenitor	0.85	Nonsignificant	—	0.00	Other	0	0
246	HEP.acute_phase.complement_metabolic	0.85	Nonsignificant	3.55e-06	1.81	Other	1,423	3,464
247	B.germinal_center.LZ_memory_precursor	0.84	Nonsignificant	—	0.37	Other	0	0
248	IPSC.neuroendocrine_primed	0.83	Nonsignificant	—	0.00	Other	0	0
249	NEU.EXC_IT.structural	0.81	Nonsignificant	1.00	0.81	Other	171	41
250	EPI.endocervical_secretory.secretory_translocon	0.79	Nonsignificant	—	0.00	Other	0	0
251	THYMO.SP_CD8_naive_stress	0.78	Nonsignificant	1.00	0.28	Other	1	1
252	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.74	Nonsignificant	—	0.00	Other	0	0
253	DC.cDC1.baseline	0.74	Nonsignificant	—	0.00	Other	0	0
254	EPI.esophageal_basal.junctional_barrier	0.73	Nonsignificant	—	0.69	Other	0	0
255	MEL.neurotrophic_migratory	0.73	Nonsignificant	—	1.35	Other	0	0
256	EPI.lung_multiciliated.baseline	0.73	Nonsignificant	—	0.75	Other	0	7
257	MAC.resident_cardiac.phagocytic_homeostasis	0.72	Nonsignificant	0.99	0.36	Other	564	1,221
258	EC.arterial.arteriole_gas_exchange	0.72	Nonsignificant	1.00	0.18	Other	238	131
259	B.germinal_center.DZ_M_phase	0.70	Nonsignificant	—	0.00	Other	0	0
260	B.germinal_center.LZ_survival	0.69	Nonsignificant	—	0.00	Other	0	0
261	EPI.tracheal_suprabasal.transitional_wound	0.69	Nonsignificant	—	0.43	Other	16	1
262	MAC.kupffer.metabolic	0.68	Nonsignificant	—	0.00	Other	25	36
263	EPI.renal_principal_cell.canonical_vasopressin	0.68	Nonsignificant	0.98	0.15	Other	2	0
264	MONO.CD14.remodeling	0.67	Nonsignificant	0.19	1.11	Other	2,373	295
265	B.germinal_center.LZ_selection	0.67	Nonsignificant	—	0.00	Other	0	0
266	NEU.EXC_CT.Ca2_signaling	0.67	Nonsignificant	—	1.32	Other	68	17
267	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.66	Nonsignificant	—	0.00	Other	5	3
268	MONO.CD16.inflammatory	0.66	Nonsignificant	1.26e-04	1.50	Other	1,640	168
269	EPI.hepatic_ductular_cholangiocyte.polarity	0.65	Nonsignificant	—	0.00	Other	0	0
270	DC.cDC2.lipid_metabolic	0.64	Nonsignificant	—	0.00	Other	0	0
271	OPC.premyelinating	0.61	Nonsignificant	0.03	2.00	Other	185	12
272	THYMO.CD8aa_IELp	0.61	Nonsignificant	—	0.00	Other	1	7
273	NEU.EXC_CT.Ca2_sensor	0.60	Nonsignificant	—	0.39	Other	0	0
274	EC.arterial.ion_pump	0.59	Nonsignificant	1.00	0.42	Other	3	2
275	EPI.skin_keratinocyte_progenitor.activated_stress	0.59	Nonsignificant	—	0.00	Other	0	0
276	THYMO.DP_early_stress	0.58	Nonsignificant	—	0.00	Other	0	0
277	HEP.pericentral_lipoprotein.ApoB_coagulation	0.57	Nonsignificant	—	0.67	Other	0	0
278	MONO.CD14.baseline	0.56	Nonsignificant	1.00	0.77	Other	2,268	76
279	EPI.salivary_duct_excretory.baseline	0.56	Nonsignificant	0.22	1.55	Other	23	57
280	IPSC.endoderm_primed	0.55	Nonsignificant	1.00	0.13	Other	0	0
281	ASTRO.homeostatic	0.54	Nonsignificant	6.47e-03	1.54	Other	200	431
282	MAC.resident_iron.stress_tolerogenic	0.54	Nonsignificant	—	0.62	Other	0	0
283	ASTRO.immature_lipid	0.53	Nonsignificant	0.46	1.29	Other	23	113
284	OPC.proliferative_immune_interact	0.53	Nonsignificant	0.72	1.03	Other	180	373
285	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.53	Nonsignificant	0.37	1.16	Other	2	9
286	HPC.CLP_B_primed	0.52	Nonsignificant	—	0.00	Other	0	0
287	NEU.EXC_IT.adhesion	0.52	Nonsignificant	1.00	0.66	Other	252	108
288	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.52	Nonsignificant	—	0.00	Other	0	0
289	THYMO.DN_preTCR	0.51	Nonsignificant	1.00	0.07	Other	41	71
290	NEU.EXC_CT.remodeling	0.51	Nonsignificant	—	0.00	Other	23	1
291	SKM.type_1_slow.oxidative	0.47	Nonsignificant	0.06	1.72	Other	802	251
292	MONO.CD16.baseline	0.47	Nonsignificant	0.34	1.12	Other	50	1
293	HEP.pericentral_lipoprotein.UPR_redox	0.47	Nonsignificant	—	0.00	Other	0	0
294	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.47	Nonsignificant	—	0.00	Other	0	0
295	EC.capillary.activated	0.47	Nonsignificant	0.68	1.18	Other	2	5
296	EPI.lung_multiciliated.stress	0.46	Nonsignificant	—	0.00	Other	67	165
297	EPI.alveolar_type_1.baseline	0.46	Nonsignificant	0.10	1.75	Other	8	0
298	MAC.MDM.APC_dendritic	0.46	Nonsignificant	0.86	1.07	Other	48	15
299	HEP.acute_phase.complement_antiviral	0.45	Nonsignificant	0.84	1.14	Other	377	751
300	T.CD4_Treg.tissue_effector	0.45	Nonsignificant	0.28	1.15	Other	16	13
301	MONO.CD16.hepatic_mac_like	0.44	Nonsignificant	0.34	1.17	Other	803	117
302	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.43	Nonsignificant	—	0.00	Other	0	0
303	EPI.esophageal_basal.activated_progenitor	0.43	Nonsignificant	0.68	0.76	Other	1	0
304	NEU.EXC_CT.projector	0.41	Nonsignificant	1.00	0.00	Other	87	26
305	EPI.lung_multiciliated.mature_motile_cilia	0.40	Nonsignificant	—	0.00	Other	0	0
306	EC.venous.adipose_lipid	0.40	Nonsignificant	1.00	0.12	Other	254	476
307	ASTRO.stress_mito	0.39	Nonsignificant	0.82	1.09	Other	47	110
308	OPC.homeostatic	0.39	Nonsignificant	0.98	0.13	Other	394	160
309	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.39	Nonsignificant	—	1.56	Other	10	20
310	SKM.type_1_slow.contractile	0.39	Nonsignificant	0.99	0.83	Other	596	8
311	MAC.resident_iron.heme_recycling	0.39	Nonsignificant	—	0.78	Other	30	37
312	EPI.tracheal_suprabasal.secretory_immune	0.38	Nonsignificant	—	0.00	Other	0	0
313	EPI.salivary_duct_excretory.stress	0.37	Nonsignificant	0.94	0.21	Other	33	68
314	EC.capillary.inflammatory	0.37	Nonsignificant	0.98	0.93	Other	27	51
315	EC.lymphatic.activated	0.37	Nonsignificant	0.76	1.39	Other	47	73
316	T.CD4_Th2.tissue_adapted	0.36	Nonsignificant	—	0.97	Other	0	0
317	EC.lymphatic.valve	0.36	Nonsignificant	—	0.50	Other	0	0
318	EC.capillary.angiocrine	0.35	Nonsignificant	0.98	0.97	Other	250	630
319	FIB.suburothelial.urothelial_interface	0.34	Nonsignificant	2.34e-04	1.98	Other	9	8
320	T.CD4_Tfh.suppression_exhaustion	0.34	Nonsignificant	0.87	1.06	Other	0	2
321	ASTRO.A2_reactive	0.33	Nonsignificant	0.82	1.05	Other	10	37
322	DC.cDC2.pro_inflammatory	0.32	Nonsignificant	1.00	0.38	Other	3	5
323	EPI.renal_immature_ureteric_bud.osmoprotective	0.32	Nonsignificant	0.68	1.14	Other	126	44
324	EC.lymphatic.baseline	0.32	Nonsignificant	0.89	0.68	Other	38	72
325	EPI.lung_club_secretory.ciliogenesis_primed	0.31	Nonsignificant	—	0.79	Other	0	0
326	DC.cDC2.proliferative	0.30	Nonsignificant	—	0.00	Other	39	71
327	EC.lymphatic.scavenger	0.30	Nonsignificant	0.89	0.46	Other	203	257
328	EC.capillary.postcap_venule	0.30	Nonsignificant	0.68	1.10	Other	355	261
329	NEU.EXC_SYT2.synaptic	0.29	Nonsignificant	—	0.48	Other	0	0
330	EC.lymphatic.tip_migratory	0.29	Nonsignificant	0.76	1.15	Other	23	37
331	EPI.ectocervical_granular.secretory_apocrine	0.29	Nonsignificant	—	0.00	Other	0	0
332	ILC2.quiescent	0.28	Nonsignificant	—	0.00	Other	0	0
333	T.CD4_Tfh.canonical_GC_helper	0.27	Nonsignificant	0.87	1.00	Other	1	2
334	SKM.type_1_slow.glycolytic	0.27	Nonsignificant	0.99	0.12	Other	362	647
335	HEP.acute_phase.baseline	0.27	Nonsignificant	1.00	0.46	Other	946	19
336	PC.IgG_systemic.metabolic	0.26	Nonsignificant	0.05	1.40	Other	46	63
337	MAC.MDM.inflammatory_phagocytic	0.25	Nonsignificant	0.86	0.99	Other	199	52
338	EC.capillary.baseline	0.24	Nonsignificant	0.99	0.77	Other	246	560
339	ASTRO.hypoxia_angiogenic	0.24	Nonsignificant	0.82	1.10	Other	5	18
340	MAC.resident_iron.APC_iron_sensing	0.24	Nonsignificant	0.82	0.87	Other	211	114
341	EPI.renal_immature_ureteric_bud.defense_secretory	0.24	Nonsignificant	0.95	0.51	Other	45	76
342	EPI.lung_club_secretory.canonical_surfactant	0.23	Nonsignificant	—	0.00	Other	74	104
343	NK.immature_bridge	0.23	Nonsignificant	0.13	1.11	Other	117	122
344	EPI.lung_club_secretory.ciliogenesis_axoneme	0.22	Nonsignificant	—	0.00	Other	0	0
345	ASTRO.synaptic_interaction	0.22	Nonsignificant	1.00	0.72	Other	76	334
346	HEP.acute_phase.stress_secretory	0.21	Nonsignificant	1.00	0.47	Other	26	3
347	EPI.renal_thick_ascending_limb.barrier_repair	0.21	Nonsignificant	1.00	0.02	Other	141	284
348	MEL.stress_glucocorticoid	0.21	Nonsignificant	0.81	0.83	Other	11	34
349	HEP.acute_phase.inflammatory	0.20	Nonsignificant	1.00	0.42	Other	382	649
350	ILC2.migratory	0.20	Nonsignificant	—	0.00	Other	0	0
351	EPI.lung_club_secretory.inflammatory	0.20	Nonsignificant	—	0.00	Other	0	0
352	EPI.alveolar_type_1.activated	0.20	Nonsignificant	—	0.00	Other	0	0
353	GRANU.MAST.activated_repair	0.20	Nonsignificant	—	0.08	Other	0	1
354	EPI.esophageal_suprabasal.differentiating_keratin	0.19	Nonsignificant	1.00	0.00	Other	131	61
355	GRANU.MAST.activated_acute	0.19	Nonsignificant	—	0.14	Other	0	0
356	MAC.resident_repair.stress_iron	0.19	Nonsignificant	0.41	1.14	Other	48	97
357	NEU.EXC_IT.transitional	0.19	Nonsignificant	1.00	0.07	Other	237	142
358	EC.capillary.stress	0.19	Nonsignificant	0.98	0.85	Other	44	36
359	MAC.resident_repair.chemokine_angiocrine	0.19	Nonsignificant	0.41	1.14	Other	87	138
360	GRANU.neutrophil.primed_degranulation	0.19	Nonsignificant	—	0.90	Other	0	0
361	GRANU.MAST.resting_granule	0.19	Nonsignificant	—	0.00	Other	0	0
362	MAC.LAM.inflammatory_APC	0.18	Nonsignificant	8.26e-06	1.27	Other	872	165
363	DC.cDC1.proliferative	0.18	Nonsignificant	—	0.00	Other	0	0
364	PERI.baseline	0.17	Nonsignificant	0.18	1.11	Other	39	66
365	PLAT.adhesion	0.17	Nonsignificant	—	0.00	Other	0	0
366	ASTRO.stress_acute	0.17	Nonsignificant	1.00	0.75	Other	60	56
367	HEP.canalicular_transport.inflammatory	0.17	Nonsignificant	0.17	1.35	Other	1,335	194
368	MONO.CD16.patrolling	0.16	Nonsignificant	1.00	0.47	Other	797	216
369	HEP.canalicular_transport.injury_stress	0.16	Nonsignificant	1.00	1.05	Other	289	24
370	NEU.EXC_IT.neuromodulated	0.16	Nonsignificant	1.00	0.03	Other	176	116
371	NEU.INH_LAMP5.rosehip	0.16	Nonsignificant	—	1.16	Other	0	0
372	MEL.secretory_quiescent	0.16	Nonsignificant	0.81	0.96	Other	19	13
373	CM.contractile_oxphos	0.15	Nonsignificant	1.00	0.04	Other	6	19
374	PERI.inflammatory	0.15	Nonsignificant	0.18	1.10	Other	40	77
375	EC.capillary.migratory	0.15	Nonsignificant	0.98	0.97	Other	181	509
376	MAC.resident_repair.lipid_phagocytic	0.15	Nonsignificant	0.17	1.48	Other	228	604
377	T.CD4_Th2.precursor	0.15	Nonsignificant	—	0.00	Other	0	0
378	MAC.resident_iron.redox_metabolic	0.15	Nonsignificant	0.82	0.90	Other	4	4
379	GRANU.neutrophil.antiviral_endotoxin	0.15	Nonsignificant	—	0.00	Other	0	0
380	MAC.resident_repair.ECM_stromal_crosstalk	0.15	Nonsignificant	0.86	0.78	Other	95	158
381	MAC.resident_iron.heme_catabolism	0.15	Nonsignificant	0.82	0.70	Other	30	51
382	HEP.canalicular_transport.pericentral_like_hypoxia	0.14	Nonsignificant	1.00	0.97	Other	326	8
383	EPI.tracheal_basal.homeostatic_progenitor	0.14	Nonsignificant	0.07	1.72	Other	285	74
384	NEU.INH_LAMP5.glial_interface	0.13	Nonsignificant	—	0.71	Other	0	0
385	MAC.LAM.lipid_phagocytosis	0.13	Nonsignificant	0.69	1.12	Other	369	328
386	T.CD4_Tcm.synapse_dynamics	0.13	Nonsignificant	0.39	1.27	Other	15	10
387	GRNLSA.EMT_insulin_signaling	0.13	Nonsignificant	0.69	1.00	Other	47	84
388	FIB.suburothelial.contractile_myofibroblast	0.13	Nonsignificant	—	0.00	Other	9	0
389	MAC.proliferating.stress	0.13	Nonsignificant	—	0.00	Other	87	136
390	T.CD4_Tfh.precursor_migratory	0.13	Nonsignificant	0.87	0.82	Other	72	27
391	PC.IgA_muocsal.plasmablast	0.12	Nonsignificant	0.20	1.23	Other	5	4
392	MAC.alveolar.stress_metabolic	0.12	Nonsignificant	0.04	1.25	Other	116	148
393	PC.IgG_systemic.interacting	0.12	Nonsignificant	0.87	0.99	Other	0	0
394	EPI.pancreatic_islet.alpha	0.12	Nonsignificant	—	0.94	Other	152	330
395	HEP.acute_phase.proliferative	0.12	Nonsignificant	—	0.00	Other	4	6
396	DC.mig.baseline	0.11	Nonsignificant	—	0.00	Other	1	0
397	FIB.suburothelial.inflammatory_prostanoid	0.11	Nonsignificant	—	0.00	Other	0	0
398	HEP.acute_phase.hypoxia_lipid	0.11	Nonsignificant	—	0.00	Other	0	0
399	T.CD4_Tfh.effector_migratory	0.11	Nonsignificant	0.87	0.93	Other	122	57
400	MAC.proliferating.DNA_replication	0.11	Nonsignificant	0.58	0.97	Other	3	6
401	MAC.resident_repair.antigen_presenting	0.11	Nonsignificant	0.41	1.13	Other	244	113
402	HEP.canalicular_transport.secretory_ERAD_UPR	0.11	Nonsignificant	1.00	0.59	Other	232	28
403	GRANU.neutrophil.tissue_patrolling	0.10	Nonsignificant	—	0.00	Other	0	0
404	FIB.barrier_purinergic.lipid_secretory	0.10	Nonsignificant	—	0.48	Other	0	0
405	EC.liver_sinusoidal.inflammatory	0.10	Nonsignificant	—	0.00	Other	223	154
406	MEL.mature_oxidative_traffic	0.10	Nonsignificant	3.45e-03	1.33	Other	247	285
407	T.CD4_naive.proteostasis	0.10	Nonsignificant	0.78	1.15	Other	14	9
408	MAC.MDM.complement_resolving	0.10	Nonsignificant	0.86	0.92	Other	440	860
409	NEU.INH_VIP.excitatory_coupled	0.10	Nonsignificant	—	0.56	Other	13	0
410	EPI.ectocervical_granular.inflammatory	0.09	Nonsignificant	—	0.00	Other	0	0
411	NEU.INH_VIP.LAMP5_hybrid	0.09	Nonsignificant	—	0.80	Other	1	9
412	ASTRO.A1_reactive	0.09	Nonsignificant	1.00	0.37	Other	433	394
413	FIB.perivascular_interface.vasomotor_tone	0.09	Nonsignificant	—	0.36	Other	0	0
414	GRNLSA.cholesterol_mevalonate	0.09	Nonsignificant	0.44	1.19	Other	9	4
415	GRNLSA.chemokine_mechanosensory	0.09	Nonsignificant	0.62	1.07	Other	1	0
416	FIB.perivascular_interface.vascular_BM_remodelling	0.09	Nonsignificant	—	0.38	Other	0	0
417	MAC.LAM.perivascular_angiocrine	0.09	Nonsignificant	—	0.78	Other	53	138
418	HEP.canalicular_transport.baseline	0.09	Nonsignificant	1.00	0.78	Other	199	477
419	HEP.canalicular_transport.ductular_like_transition	0.09	Nonsignificant	1.00	0.33	Other	400	87
420	MAC.microglia_like.inflammatory_chemokine	0.09	Nonsignificant	—	0.34	Other	20	32
421	T.CD4_Treg.APC_interactive	0.08	Nonsignificant	0.89	0.87	Other	118	28
422	FIB.lung_alveolar.stress_interacting	0.08	Nonsignificant	—	0.97	Other	0	0
423	GRNLSA.secretory_remodeling	0.08	Nonsignificant	0.21	1.28	Other	90	25
424	MAC.LAM.lipid_opsonization	0.08	Nonsignificant	0.97	0.91	Other	45	14
425	SMC.activated	0.08	Nonsignificant	0.08	1.28	Other	2	5
426	EPI.tracheal_basal.activated_stress	0.08	Nonsignificant	0.99	0.13	Other	32	0
427	NEU.INH_VIP.opioid	0.08	Nonsignificant	—	0.61	Other	50	9
428	NEU.INH_VIP.nuclear_reg	0.08	Nonsignificant	—	0.09	Other	20	4
429	PC.IgG_systemic.stress	0.07	Nonsignificant	—	0.04	Other	1	5
430	NEU.INH_VIP.regulatory_remodeling	0.07	Nonsignificant	—	0.44	Other	6	1
431	T.CD4_Trm.activated	0.07	Nonsignificant	0.43	1.15	Other	32	26
432	T.CD4_naive.proteostasis_mitoprot	0.06	Nonsignificant	0.78	1.15	Other	15	37
433	CHOND.articular_collagen	0.06	Nonsignificant	2.05e-03	1.19	Other	551	266
434	MEL.dedifferentiated_migratory	0.06	Nonsignificant	—	0.00	Other	0	0
435	NEU.INH_LAMP5.exc_inh_balance	0.06	Nonsignificant	—	0.00	Other	46	2
436	NEU.INH_VIP.matrix	0.06	Nonsignificant	—	0.16	Other	24	77
437	PC.IgA_muocsal.baseline	0.06	Nonsignificant	0.56	1.04	Other	3	5
438	T.CD4_transitional.primed_helper_effector	0.06	Nonsignificant	0.44	1.18	Other	19	43
439	T.CD4_Treg.central_naive_like	0.06	Nonsignificant	0.28	1.11	Other	333	45
440	NEU.INH_LAMP5.projecting	0.06	Nonsignificant	—	0.00	Other	0	0
441	MAC.MDM.LAM_like	0.06	Nonsignificant	0.86	0.79	Other	12	14
442	NEU.INH_PVALB.fastspike	0.05	Nonsignificant	—	0.94	Other	24	22
443	PC.IgA_muocsal.migratory	0.05	Nonsignificant	0.64	0.98	Other	4	1
444	EPI.tracheal_submucosal_gland.acinar_serous	0.05	Nonsignificant	—	0.73	Other	0	0
445	ILC2.activated	0.05	Nonsignificant	—	6.94e-17	Other	0	0
446	EC.liver_sinusoidal.prostanoid	0.05	Nonsignificant	—	0.00	Other	11	64
447	NEU.INH_VIP.canonical_disinhibitory	0.05	Nonsignificant	0.60	0.89	Other	59	38
448	EPI.salivary_intercalated_defense.inflammatory	0.05	Nonsignificant	0.01	1.24	Other	152	360
449	GRNLSA.lipid_hypoxia	0.05	Nonsignificant	0.83	0.85	Other	28	0
450	FIB.suburothelial.homeostasis_matrix	0.04	Nonsignificant	1.00	0.00	Other	258	921
451	T.CD8_naive.mito_proteostasis	0.04	Nonsignificant	1.25e-03	1.41	Other	428	100
452	T.CD4_naive.gut_prone	0.04	Nonsignificant	0.78	1.08	Other	35	70
453	PC.IgA_muocsal.activated	0.04	Nonsignificant	0.56	1.02	Other	17	8
454	CM.inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
455	NEU.INH_VIP.serotonergic	0.04	Nonsignificant	—	0.00	Other	9	2
456	EPI.pancreatic_acinar.stress	0.04	Nonsignificant	0.41	1.27	Other	28	28
457	FIB.lung_alveolar.mito_secretory	0.04	Nonsignificant	—	0.00	Other	0	0
458	T.CD4_Trm.metal_stress	0.04	Nonsignificant	0.43	1.19	Other	34	58
459	PC.IgG_systemic.secretory	0.04	Nonsignificant	0.99	0.44	Other	0	0
460	SMC.metabolic	0.04	Nonsignificant	0.82	0.87	Other	14	40
461	T.CD4_Tcm.Th2_like	0.04	Nonsignificant	0.39	1.22	Other	23	55
462	MUSC.activated_migratory	0.03	Nonsignificant	0.18	1.55	Other	6	7
463	T.CD4_naive.activated_stress	0.03	Nonsignificant	0.78	1.07	Other	339	429
464	EPI.alveolar_type_2.baseline_surfactant	0.03	Nonsignificant	0.34	1.19	Other	64	9
465	PERI.angiocrine	0.03	Nonsignificant	1.00	0.81	Other	93	102
466	MAC.LAM.anti_inflammatory	0.03	Nonsignificant	0.97	0.72	Other	86	132
467	NEU.INH_PVALB.metabotropic	0.03	Nonsignificant	—	0.84	Other	0	0
468	NEU.INH_VIP.enkephalinergic	0.03	Nonsignificant	—	0.00	Other	0	0
469	T.CD4_Trm.central_like	0.03	Nonsignificant	0.43	1.09	Other	38	31
470	NEU.INH_VIP.develop_niche	0.03	Nonsignificant	—	0.00	Other	0	0
471	T.CD4_naive.resist_bystander	0.03	Nonsignificant	0.78	1.15	Other	40	25
472	ASPC.inflammatory	0.03	Nonsignificant	0.83	1.08	Other	21	61
473	EPI.alveolar_type_2.stress_response	0.03	Nonsignificant	0.31	1.28	Other	675	1,562
474	T.CD4_naive.purinergic	0.03	Nonsignificant	0.78	1.08	Other	49	1
475	T.CD4_naive.mature	0.03	Nonsignificant	0.78	1.00	Other	211	100
476	FIB.perivascular_interface.lipid_shuttle	0.03	Nonsignificant	—	0.00	Other	51	170
477	ASTRO.neuromodulatory	0.03	Nonsignificant	1.00	0.11	Other	34	172
478	T.CD8_Tcm.NK_like	0.03	Nonsignificant	0.35	1.14	Other	334	581
479	EC.liver_sinusoidal.remodeling_lipotoxicity	0.03	Nonsignificant	—	0.00	Other	90	58
480	MONO.CD14.inflammatory	0.03	Nonsignificant	1.00	0.47	Other	92	134
481	T.CD4_naive.homeostatic	0.03	Nonsignificant	0.78	1.01	Other	215	108
482	T.CD4_naive.neddylation_mitoprot	0.03	Nonsignificant	0.78	1.06	Other	93	56
483	CHOND.remodeling	0.03	Nonsignificant	—	0.00	Other	5	0
484	NEU.EXC_SYT2.nuclear_reg	0.03	Nonsignificant	—	0.00	Other	0	0
485	T.CD4_transitional.tissue_enagement	0.02	Nonsignificant	0.80	1.10	Other	5	11
486	ASPC.remodeling	0.02	Nonsignificant	0.83	1.07	Other	106	354
487	GRNLSA.proliferative_migratory	0.02	Nonsignificant	0.62	1.06	Other	248	292
488	T.CD4_Tcm.baseline	0.02	Nonsignificant	0.72	1.07	Other	61	31
489	EC.liver_sinusoidal.hypoxia_metabolic	0.02	Nonsignificant	1.00	0.11	Other	183	107
490	T.CD8_Tem.signaling_turnover	0.02	Nonsignificant	0.06	1.20	Other	425	683
491	T.CD4_naive.Treg_like	0.02	Nonsignificant	0.78	1.05	Other	121	72
492	T.CD4_naive.mature_mitoprot	0.02	Nonsignificant	0.78	0.99	Other	212	476
493	T.CD4_naive.survival_neddylation	0.02	Nonsignificant	0.97	0.86	Other	26	38
494	MAC.LAM.antimicrobial	0.02	Nonsignificant	0.97	0.69	Other	389	93
495	SMC.contractile	0.02	Nonsignificant	0.53	1.06	Other	80	588
496	T.CD4_naive.neddylation	0.02	Nonsignificant	0.97	0.88	Other	104	222
497	T.CD4_Tcm.migratory_cilium	0.02	Nonsignificant	0.72	1.10	Other	5	10
498	T.CD8_naive.effector_transition	0.02	Nonsignificant	0.80	1.13	Other	35	62
499	T.CD8_naive.nfkb_related	0.02	Nonsignificant	0.80	1.11	Other	1	0
500	NEU.INH_PVALB.nuclear_reg	0.02	Nonsignificant	0.85	0.54	Other	25	12
501	T.CD8_Trm.inflammatory	0.02	Nonsignificant	0.09	1.17	Other	124	176
502	EPI.pancreatic_acinar.inflammatory_regenerative	0.02	Nonsignificant	0.42	1.20	Other	25	113
503	NEU.INH_PVALB.chandelier	0.02	Nonsignificant	0.85	0.46	Other	19	16
504	EPI.alveolar_type_2.injury_primed	0.02	Nonsignificant	0.57	0.96	Other	434	245
505	T.CD4_Tcm.crosstalk_myeloid	0.02	Nonsignificant	0.72	1.10	Other	5	4
506	FIB.hepatic_stellate_cell.fibrogenic	0.02	Nonsignificant	—	0.73	Other	0	0
507	NK.cytokine_axis_baseline	0.02	Nonsignificant	1.00	0.98	Other	1,172	116
508	T.CD4_Tcm.imprinted_splicing	0.02	Nonsignificant	0.72	1.04	Other	6	17
509	T.CD4_transitional.APC_interacting	0.02	Nonsignificant	0.80	1.05	Other	10	14
510	NK.cytokine_tissue_activation	0.01	Nonsignificant	1.00	1.07	Other	267	450
511	NK.cytokine_lung_immediate_early	0.01	Nonsignificant	1.00	0.96	Other	424	274
512	T.CD4_Tcm.tissue_homing	0.01	Nonsignificant	0.39	1.20	Other	78	46
513	FIB.skin_sheath.stress_chaperone	0.01	Nonsignificant	—	1.03	Other	0	0
514	NEU.INH_VIP.cannabinoid	0.01	Nonsignificant	—	0.00	Other	0	0
515	NEU.INH_PVALB.neuromodulatory	0.01	Nonsignificant	—	0.00	Other	0	0
516	T.CD8_naive.vesicle_secretory	0.01	Nonsignificant	0.83	1.02	Other	42	0
517	T.CD8_naive.lipid_synthesis	0.01	Nonsignificant	0.80	1.09	Other	6	4
518	NEU.INH_PVALB.serotonergic	0.01	Nonsignificant	—	0.00	Other	0	0
519	NK.adaptive_immature_precursor	0.01	Nonsignificant	1.00	0.94	Other	358	111
520	T.CD4_Tcm.APC_mimicry	0.01	Nonsignificant	0.97	0.94	Other	54	43
521	FIB.neurolectin_mucosa.inflammatory	0.01	Nonsignificant	0.39	1.34	Other	52	110
522	SCHWN.translation_boost	0.01	Nonsignificant	—	0.38	Other	8	1
523	T.CD4_Treg.Tr1_like	0.01	Nonsignificant	—	0.00	Other	8	8
524	NK.cytokine_quiescent	0.01	Nonsignificant	1.00	0.99	Other	623	1,062
525	EPI.tracheal_submucosal_gland.ductal_luminal	9.99e-03	Nonsignificant	—	0.00	Other	0	0
526	T.CD8_Tcm.baseline	9.76e-03	Nonsignificant	0.35	1.10	Other	90	89
527	ASPC.baseline	9.69e-03	Nonsignificant	0.83	1.03	Other	363	170
528	T.CD4_naive.survival	9.61e-03	Nonsignificant	0.97	0.75	Other	12	17
529	MUSC.quiescent_reservoir	9.59e-03	Nonsignificant	0.78	0.91	Other	2	8
530	T.CD4_Th17.migratory	9.33e-03	Nonsignificant	0.45	1.11	Other	13	23
531	ASPC.adipocyte_capillary_interface	9.25e-03	Nonsignificant	0.83	1.05	Other	21	54
532	MUSC.early_activation	9.23e-03	Nonsignificant	0.78	0.70	Other	4	32
533	FIB.neurolectin_mucosa.nerve_interface	9.20e-03	Nonsignificant	—	0.32	Other	4	0
534	T.CD4_naive.survival_mitoprot	8.96e-03	Nonsignificant	0.97	0.70	Other	13	7
535	T.CD8_Tem.TEMRA	8.56e-03	Nonsignificant	0.74	1.05	Other	920	1,088
536	MUSC.baseline	8.48e-03	Nonsignificant	0.78	0.79	Other	0	0
537	MAC.microglia_like.patrolling_adhesive	8.47e-03	Nonsignificant	—	0.00	Other	0	0
538	T.CD4_transitional.primed_cytotoxic	8.44e-03	Nonsignificant	0.94	0.93	Other	28	30
539	FIB.neurolectin_mucosa.axon_responsive	8.07e-03	Nonsignificant	0.49	1.01	Other	10	10
540	T.CD4_Tcm.DC_interact	8.03e-03	Nonsignificant	0.97	0.90	Other	72	32
541	NK.cytokine_vascular_patrolling	8.03e-03	Nonsignificant	1.00	0.97	Other	863	94
542	T.CD8_naive.baseline	7.90e-03	Nonsignificant	0.91	0.95	Other	142	2
543	T.CD4_Tcm.stress	7.68e-03	Nonsignificant	0.72	1.08	Other	5	11
544	FIB.neurolectin_mucosa.remodeling_repair	7.48e-03	Nonsignificant	—	0.00	Other	4	2
545	T.CD4_Tcm.Tfh_like	7.44e-03	Nonsignificant	0.97	0.86	Other	102	214
546	T.CD4_transitional.baseline	7.36e-03	Nonsignificant	0.95	0.82	Other	59	97
547	T.CD8_naive.splicing_enriched	7.07e-03	Nonsignificant	0.91	0.97	Other	120	16
548	MONO.CD14.repair_M2_like	6.54e-03	Nonsignificant	1.00	0.16	Other	550	1,495
549	FIB.hepatic_stellate_cell.inflammatory	6.45e-03	Nonsignificant	—	0.00	Other	0	0
550	FIB.skin_neurosecretory.baseline	6.12e-03	Nonsignificant	—	0.00	Other	0	0
551	ASPC.niche_keeping_progenitor	6.04e-03	Nonsignificant	0.83	1.01	Other	52	219
552	NK.adaptive_axis_baseline	5.46e-03	Nonsignificant	0.18	1.09	Other	1,008	153
553	T.CD4_Th17.baseline	5.44e-03	Nonsignificant	0.60	0.98	Other	51	5
554	T.CD4_Trm.baseline	5.41e-03	Nonsignificant	0.96	0.95	Other	31	21
555	T.CD4_Tcm.secretory	5.40e-03	Nonsignificant	0.97	0.91	Other	20	11
556	T.CD8_naive.cytokine_dampened	5.33e-03	Nonsignificant	0.91	0.84	Other	71	4
557	T.CD8_Tem.early_helper_like	5.30e-03	Nonsignificant	0.27	1.13	Other	445	755
558	T.CD8_transitional.Trm_primed	4.91e-03	Nonsignificant	0.68	1.02	Other	108	15
559	EPI.pancreatic_islet.beta	4.76e-03	Nonsignificant	0.98	0.28	Other	42	57
560	T.CD4_Trm.cytotoxic_effector	4.73e-03	Nonsignificant	0.96	0.96	Other	118	77
561	T.CD4_Tcm.effector_like	4.17e-03	Nonsignificant	0.89	0.98	Other	293	533
562	T.CD4_Tcm.retro_ZNF117	4.08e-03	Nonsignificant	0.72	1.05	Other	5	9
563	T.CD8_Tcm.helper_like	3.98e-03	Nonsignificant	0.93	0.84	Other	81	159
564	T.CD4_Tem.transitional_CM	3.95e-03	Nonsignificant	0.56	1.05	Other	31	20
565	FIB.reticular.stromal_niche	3.84e-03	Nonsignificant	0.11	1.28	Other	0	0
566	ASPC.preadipocyte_lipid_primed	3.67e-03	Nonsignificant	0.83	1.00	Other	331	129
567	FIB.hepatic_stellate_cell.contractile	3.64e-03	Nonsignificant	—	0.00	Other	0	0
568	T.CD4_Tem.inflammatory	3.50e-03	Nonsignificant	0.56	1.05	Other	28	6
569	PERI.cardiac_skeletal	3.37e-03	Nonsignificant	1.00	0.17	Other	313	630
570	FIB.adventitial.inflammatory_activated	3.35e-03	Nonsignificant	0.51	1.15	Other	100	473
571	FIB.interstitial.remodeling	3.28e-03	Nonsignificant	1.00	1.02	Other	31	9
572	T.CD4_Tem.long_term_memory	3.20e-03	Nonsignificant	0.56	1.03	Other	314	587
573	ASPC.activated	3.13e-03	Nonsignificant	0.83	0.94	Other	164	162
574	T.CD8_transitional.effector_primed	3.05e-03	Nonsignificant	0.68	1.02	Other	435	151
575	T.CD4_Tcm.RNA_control	2.93e-03	Nonsignificant	0.97	0.83	Other	96	4
576	T.CD8_transitional.early	2.89e-03	Nonsignificant	0.68	1.00	Other	327	55
577	NEU.EXC_NTNG1.nuclear_reg	2.60e-03	Nonsignificant	—	0.67	Other	0	0
578	FIB.interstitial.immune_interact	2.55e-03	Nonsignificant	0.74	1.09	Other	12	1
579	FIB.adventitial.adhesion_lipid	2.48e-03	Nonsignificant	0.51	1.16	Other	58	209
580	T.CD8_naive.innate_like	2.45e-03	Nonsignificant	0.91	0.77	Other	10	1
581	GRNLSA.stress_metabolic	2.41e-03	Nonsignificant	—	0.00	Other	1	2
582	T.CD8_Tem.baseline	2.40e-03	Nonsignificant	0.74	1.04	Other	458	356
583	EPI.pancreatic_acinar.quiet_dedifferentiation	2.38e-03	Nonsignificant	1.00	0.92	Other	142	171
584	FIB.skin_tenogenic.baseline	2.31e-03	Nonsignificant	—	0.00	Other	0	2
585	NK.cytokine_biosynthetic_primed	2.28e-03	Nonsignificant	1.00	0.88	Other	360	21
586	T.CD4_Th17.cytotoxic	2.19e-03	Nonsignificant	0.56	1.05	Other	332	123
587	EPI.pancreatic_acinar.adhesion_remodeling	2.18e-03	Nonsignificant	0.42	1.19	Other	210	784
588	T.CD8_Tcm.gut_homing	2.18e-03	Nonsignificant	0.26	1.20	Other	380	112
589	ASPC.mesothelial_like	2.11e-03	Nonsignificant	0.83	1.20	Other	143	486
590	FIB.adventitial.baseline	1.99e-03	Nonsignificant	0.71	1.03	Other	157	278
591	FIB.interstitial.mesenchymal_regulator	1.88e-03	Nonsignificant	1.00	0.97	Other	4	4
592	T.MAIT.early_activation	1.83e-03	Nonsignificant	0.98	1.13	Other	57	4
593	SCHWN.reactive_inflammatory	1.72e-03	Nonsignificant	—	0.46	Other	0	0
594	T.CD4_Tcm.regulatory_poised	1.69e-03	Nonsignificant	0.97	0.70	Other	2	3
595	EPI.salivary_myoepithelial.contractile_repair	1.50e-03	Nonsignificant	—	1.30	Other	3	9
596	T.CD8_Trm.homeostatic	1.46e-03	Nonsignificant	0.80	0.95	Other	42	5
597	ASPC.secretory	1.46e-03	Nonsignificant	0.83	0.97	Other	76	5
598	EPI.pancreatic_acinar.metabolic_onecarbon	1.42e-03	Nonsignificant	1.00	0.86	Other	287	328
599	FIB.tracheal_subepithelial.baseline	1.41e-03	Nonsignificant	—	0.00	Other	0	0
600	FIB.skin_sheath.ECM_immune	1.38e-03	Nonsignificant	—	0.00	Other	0	0
601	T.CD8_Trm.dendritic_recruiter	1.31e-03	Nonsignificant	0.80	0.98	Other	47	85
602	FIB.skin_sheath.neuro_vascular_interface	1.26e-03	Nonsignificant	—	0.00	Other	0	0
603	FIB.barrier_purinergic.stress_GF_binding	1.24e-03	Nonsignificant	—	0.00	Other	0	0
604	NK.adaptive_classII_inhibitory	1.04e-03	Nonsignificant	1.00	0.84	Other	880	154
605	NK.adaptive_HLAE_tuned	9.83e-04	Nonsignificant	1.00	0.66	Other	1,124	189
606	MAC.microglia_like.phagocytic_redox	9.46e-04	Nonsignificant	—	0.00	Other	0	0
607	FIB.adventitial.complement_angiocrine	9.39e-04	Nonsignificant	0.76	0.99	Other	153	684
608	NK.cytokine_tissue_resident	8.99e-04	Nonsignificant	1.00	0.75	Other	74	82
609	ASPC.stem_like_progenitor	8.26e-04	Nonsignificant	0.83	0.99	Other	300	842
610	FIB.reticular.stress_metallothionein	7.98e-04	Nonsignificant	—	0.00	Other	3	32
611	NK.cytokine_repair_primed	7.75e-04	Nonsignificant	1.00	0.78	Other	266	11
612	GRNLSA.p53_damage	7.66e-04	Nonsignificant	—	0.00	Other	13	10
613	T.MAIT.migratory	7.03e-04	Nonsignificant	0.98	1.12	Other	10	1
614	MAC.alveolar.biosynthetic_sterol_heme	7.01e-04	Nonsignificant	0.89	1.07	Other	347	40
615	NK.adaptive_terminal_cytotoxic	6.11e-04	Nonsignificant	1.00	0.67	Other	485	802
616	T.CD8_Tcm.effector_bias	6.03e-04	Nonsignificant	0.41	1.06	Other	199	329
617	T.CD4_Trm.stress_adaptive	6.03e-04	Nonsignificant	0.96	0.89	Other	8	22
618	FIB.interstitial.mesenchymal_APC	6.00e-04	Nonsignificant	1.00	0.86	Other	81	33
619	FIB.adventitial.mito_secretory	5.65e-04	Nonsignificant	0.78	0.94	Other	21	7
620	EPI.salivary_intercalated_defense.basal_EMT	5.47e-04	Nonsignificant	—	0.17	Other	0	0
621	FIB.reticular.immune_interface	5.43e-04	Nonsignificant	—	0.03	Other	1	6
622	T.CD8_Trm.muscosal_Tc17	5.31e-04	Nonsignificant	0.80	1.00	Other	19	38
623	FIB.adventitial.PI16_matrix	5.19e-04	Nonsignificant	0.71	1.06	Other	70	90
624	T.CD8_Tem.stress_adapted	5.09e-04	Nonsignificant	0.93	0.85	Other	607	520
625	SCHWN.axon_contact_cardiac	4.86e-04	Nonsignificant	0.98	0.28	Other	18	63
626	T.CD4_cytotoxic.NK_adapted	4.54e-04	Nonsignificant	0.77	1.15	Other	82	33
627	NK.adaptive_adipose_stress	4.10e-04	Nonsignificant	1.00	0.62	Other	374	39
628	FIB.interstitial.lipid_matrix	4.09e-04	Nonsignificant	1.00	0.85	Other	258	191
629	FIB.transitioning.matrix_stress	4.08e-04	Nonsignificant	—	0.17	Other	47	138
630	FIB.barrier_secretory.homeostasis	3.50e-04	Nonsignificant	—	0.17	Other	0	0
631	T.CD8_Trm.cytotoxic	3.48e-04	Nonsignificant	0.96	0.77	Other	165	85
632	T.CD8_transitional.stress	3.45e-04	Nonsignificant	—	0.74	Other	24	34
633	ADIPO.hypoxia_remodelling	3.34e-04	Nonsignificant	—	0.76	Other	29	105
634	T.CD4_Trm.helper_like	3.09e-04	Nonsignificant	0.98	0.76	Other	84	147
635	EPI.salivary_intercalated_defense.canonical_antimicrobial	2.95e-04	Nonsignificant	1.00	0.38	Other	11	22
636	OLG.stress	2.70e-04	Nonsignificant	0.85	1.04	Other	232	8
637	FIB.adventitial.mechano_chemo_sensing	2.35e-04	Nonsignificant	0.98	0.75	Other	135	524
638	T.CD4_Tem.cytotoxic_effector	1.99e-04	Nonsignificant	0.99	0.73	Other	225	398
639	FIB.adventitial.activated_remodelling	1.82e-04	Nonsignificant	—	0.38	Other	141	319
640	T.CD4_cytotoxic.terminal_effector	1.77e-04	Nonsignificant	0.77	1.03	Other	286	21
641	T.CD8_Tem.motility_primed	1.59e-04	Nonsignificant	0.90	0.88	Other	269	4
642	EPI.pancreatic_islet.delta	1.44e-04	Nonsignificant	—	0.00	Other	0	0
643	MONO.CD14.cord_tolerance	1.34e-04	Nonsignificant	1.00	0.06	Other	864	753
644	NEU.EXC_NTNG1.synaptic	1.34e-04	Nonsignificant	—	0.00	Other	0	0
645	T.MAIT.MAPK_brake	1.16e-04	Nonsignificant	0.98	1.07	Other	44	66
646	EPI.pancreatic_acinar.baseline	1.08e-04	Nonsignificant	1.00	0.33	Other	274	163
647	EPI.salivary_myoepithelial.junctional_transport	9.48e-05	Nonsignificant	0.83	1.13	Other	66	121
648	MAC.alveolar.scavenging_endocytic	7.12e-05	Nonsignificant	—	0.00	Other	140	283
649	T.gamma_delta.early_effector	6.65e-05	Nonsignificant	0.57	1.03	Other	89	0
650	T.gamma_delta.cytotoxic_effector	6.57e-05	Nonsignificant	0.57	1.03	Other	349	109
651	EPI.salivary_serous_acinar.secretory_active	6.37e-05	Nonsignificant	1.00	0.00	Other	242	69
652	T.CD8_transitional.APC_like	6.33e-05	Nonsignificant	0.99	0.84	Other	205	62
653	MAC.alveolar.capillary_interacting	4.41e-05	Nonsignificant	0.89	0.89	Other	113	181
654	CHOND.angiogenic	4.07e-05	Nonsignificant	—	0.39	Other	0	0
655	FIB.transitioning.motility_remodelling	3.89e-05	Nonsignificant	—	0.00	Other	0	0
656	ASPC.proliferative	3.31e-05	Nonsignificant	0.83	0.85	Other	33	85
657	FIB.skin_papillary.baseline	2.48e-05	Nonsignificant	—	0.00	Other	0	0
658	MAC.alveolar.inflammatory	2.29e-05	Nonsignificant	0.99	0.48	Other	208	312
659	MAC.alveolar.lipid_autophagy	1.34e-05	Nonsignificant	—	0.00	Other	35	44
660	CHOND.activated_fibro_like	1.05e-05	Nonsignificant	1.00	0.49	Other	531	188
661	T.CD4_cytotoxic.activated	9.89e-06	Nonsignificant	0.77	0.95	Other	3	1
662	T.CD4_cytotoxic.precursor	7.92e-06	Nonsignificant	0.77	1.08	Other	156	67
663	ADIPO.immature	7.66e-06	Nonsignificant	—	0.00	Other	24	40
664	NK.adaptive_biosynthetic_primed	4.66e-06	Nonsignificant	1.00	0.03	Other	244	405
665	FIB.transitioning.secretory_procollagen	4.44e-06	Nonsignificant	—	0.61	Other	0	0
666	OLG.myelinating_mature	3.77e-06	Nonsignificant	0.85	1.02	Other	363	94
667	T.gamma_delta.central_memory	3.71e-06	Nonsignificant	0.93	0.89	Other	460	919
668	T.CD4_cytotoxic.baseline	3.54e-06	Nonsignificant	0.77	0.84	Other	0	0
669	CHOND.pro_inflammatory	2.79e-06	Nonsignificant	1.00	0.54	Other	181	351
670	EPI.salivary_myoepithelial.activated	1.58e-06	Nonsignificant	1.00	0.84	Other	85	281
671	T.MAIT.cytotoxic	8.78e-07	Nonsignificant	0.98	0.92	Other	52	15
672	ADIPO.thermogenic	7.45e-07	Nonsignificant	—	0.14	Other	0	0
673	T.MAIT.vesicle	5.48e-07	Nonsignificant	0.98	0.79	Other	37	65
674	T.MAIT.quiescent	3.99e-07	Nonsignificant	0.98	0.62	Other	100	5
675	ASPC.signal_integrator	2.91e-07	Nonsignificant	—	0.00	Other	0	0
676	FIB.barrier_secretory.remodeling	2.00e-07	Nonsignificant	—	0.00	Other	0	0
677	EPI.salivary_myoepithelial.baseline	9.14e-08	Nonsignificant	1.00	0.51	Other	42	141
678	FIB.interstitial.stress_secretory	8.07e-08	Nonsignificant	1.00	0.15	Other	92	56
679	FIB.reticular.ECM_builder	4.61e-08	Nonsignificant	—	0.00	Other	0	0
680	T.MAIT.stress	1.62e-08	Nonsignificant	—	0.00	Other	0	0
681	FIB.transitioning.ISG_primed_interface	1.24e-08	Nonsignificant	—	0.00	Other	17	80
682	GRNLSA.angiocrine_mechanosensory	3.80e-09	Nonsignificant	—	0.00	Other	0	0
683	ADIPO.inflammatory	3.33e-09	Nonsignificant	—	0.00	Other	0	0
684	OLG.myelinating_stress	2.07e-09	Nonsignificant	0.85	1.03	Other	232	62
685	OLG.regulatory	3.39e-10	Nonsignificant	0.96	0.98	Other	353	73
686	OLG.regulatory_activated	2.68e-10	Nonsignificant	0.85	1.05	Other	196	614
687	OLG.reactive_repair	2.04e-12	Nonsignificant	0.96	0.89	Other	385	385
688	OLG.vesicle_trafficking	7.59e-13	Nonsignificant	0.96	0.82	Other	124	10

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

3 unique genes. Showing 1–3. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ST6GAL1	02-Medium	0.61	10.70	G1	C2	EC.liver_sinusoidal.secretory_lipoprotein (L2), EPI.renal_principal_cell.canonical_vasopressin (L2), THYMO.SP_CD4_naive (L2)	B.memory (Tier: specific) EC.heart_remodeling (Tier: specific) EC.heart_remodeling.angiocrine (Tier: specific) B.naive.receptor_recycle (Tier: relevant) EC.heart_remodeling.activated_acute (Tier: relevant) EC.heart_remodeling.capillary_metabolic (Tier: relevant) EC.heart_remodeling.remodeling_stalk (Tier: relevant)	72 cells — complete matches	105	163
ADIPOQ	02-Medium	0.48	11.17	G2	C1	adipocyte (L1), ADIPO.adipocyte (L1S)	—	6 cells — complete matches	6	5
RPL39L	02-Medium	0.39	7.09	G2	C1	—	B.naive.receptor_recycle (Tier: relevant) EPI.ileal_enterocyte_crypt.proliferative_G2M (Tier: relevant) EPI.ileal_enterocyte_crypt.proliferative_S (Tier: relevant)	25 cells — complete matches	2	2

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.