Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000057 · All tissues

Alcoholic liver disease: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Alcoholic liver disease

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte_precursor_cell	18.43	Significant	8.39e-15	1.48	Specific	461	1,454
2	schwann_cell	15.98	Significant	1.90e-03	1.42	Specific	10	57
3	neuron	11.21	Significant	9.10e-29	1.46	Specific	330	1,328
4	skeletal_muscle_cell	5.10	Nominal	4.14e-10	1.29	Other	944	2,600
5	cardiomyocyte	2.33	Nonsignificant	2.19e-07	1.17	Other	533	2,045
6	thymocyte	2.32	Nonsignificant	8.17e-04	1.17	Other	168	512
7	muscle_stem_cell	2.31	Nonsignificant	0.31	1.15	Other	7	27
8	epithelial_cell	2.28	Nonsignificant	1.99e-26	1.20	Other	24	47
9	melanocyte	2.11	Nonsignificant	0.59	1.09	Other	97	309
10	fibroblast	1.82	Nonsignificant	0.04	1.07	Other	184	826
11	adipocyte	1.78	Nonsignificant	0.72	1.12	Other	33	111
12	oligodendrocyte	1.69	Nonsignificant	2.21e-03	1.11	Other	385	1,507
13	platelet	1.63	Nonsignificant	—	0.65	Other	85	104
14	plasma_cell	1.41	Nonsignificant	1.00	0.97	Other	17	24
15	innate_lymphoid_cell_2	1.23	Nonsignificant	0.73	1.14	Other	3	8
16	granulocyte	1.18	Nonsignificant	1.00	0.96	Other	5	6
17	B_cell	1.06	Nonsignificant	1.00	0.99	Other	356	694
18	dendritic_cell	1.04	Nonsignificant	1.00	0.91	Other	496	724
19	adipose_stem_and_progenitor_cell	0.86	Nonsignificant	1.00	0.87	Other	327	954
20	induced_pluripotent_stem_cell	0.82	Nonsignificant	0.69	1.02	Other	0	0
21	monocyte	0.48	Nonsignificant	1.00	0.71	Other	2,176	3,871
22	astrocyte	0.44	Nonsignificant	1.00	0.78	Other	256	1,203
23	mesothelial_cell	0.43	Nonsignificant	1.00	0.84	Other	6	36
24	endothelial_cell	0.27	Nonsignificant	1.00	0.65	Other	373	974
25	T_cell	0.24	Nonsignificant	1.00	0.56	Other	470	959
26	haematopoietic_progenitor_cell	0.14	Nonsignificant	1.00	0.69	Other	262	502
27	smooth_muscle_cell	0.13	Nonsignificant	1.00	0.49	Other	27	139
28	chondrocyte	0.09	Nonsignificant	1.00	0.50	Other	548	1,069
29	pericyte	0.08	Nonsignificant	1.00	0.45	Other	128	517
30	macrophage	0.06	Nonsignificant	1.00	0.85	Other	813	1,732
31	microglia	0.02	Nonsignificant	1.00	0.32	Other	61	129
32	natural_killer_cell	0.02	Nonsignificant	1.00	0.37	Other	1,204	2,052
33	granulosa_cell	9.39e-04	Nonsignificant	1.00	0.18	Other	293	670
34	hepatocyte	4.53e-04	Nonsignificant	1.00	0.22	Other	1,515	3,822

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	NEU.INH_PVALB	18.52	Significant	3.19e-04	2.27	—	193	183
2	OPC.oligodendrocyte_precursor_cell	18.43	Significant	—	—	Specific	413	1,269
3	EPI.skin_keratinocyte_basal	16.52	Significant	—	2.41	Relevant	13	26
4	SCHWN.schwann_cell	15.98	Significant	—	—	Specific	7	33
5	EPI.salivary_duct_excretory	15.77	Significant	0.03	1.31	Specific	85	180
6	NEU.EXC_CT	15.52	Significant	7.72e-03	1.89	—	362	384
7	NEU.INH_LAMP5	13.58	Significant	0.04	1.72	—	263	532
8	NEU.INH_VIP	11.93	Significant	0.30	1.22	—	241	366
9	EPI.skin_sebaceous_duct_luminal	10.63	Significant	0.03	1.35	Specific	100	249
10	EPI.skin_interfollicular_spinous	9.82	Significant	9.68e-04	1.37	Specific	260	563
11	EPI.salivary_intercalated_defense	9.67	Significant	0.03	1.27	Specific	81	161
12	EPI.skin_keratinocyte_progenitor	9.08	Significant	—	1.47	Relevant	0	3
13	EPI.skin_sweat_duct_keratinocyte	8.76	Significant	0.04	1.30	Specific	146	301
14	NEU.EXC_IT	8.66	Significant	1.00	0.05	—	411	192
15	NEU.EXC_SYT2	8.20	Significant	—	0.00	—	40	77
16	EPI.skin_hair_follicle_companion	8.11	Significant	—	1.34	Relevant	8	12
17	SKM.type_2_fast	7.76	Significant	3.32e-40	2.83	Specific	972	2,639
18	EPI.tracheal_suprabasal	7.37	Significant	0.53	1.25	Relevant	29	56
19	EPI.skin_keratinocyte_proliferating	7.21	Significant	0.97	1.11	Relevant	47	76
20	EPI.colonocyte	5.95	Significant	2.26e-03	1.26	Other	294	815
21	EPI.tracheal_basal	5.51	Significant	0.03	1.27	Specific	398	1,120
22	EPI.lung_multiciliated	5.01	Nominal	0.97	1.11	Other	16	49
23	EPI.skin_hair_follicle_bulge	4.75	Nominal	0.53	1.15	Other	51	178
24	EPI.renal_proximal_tubule	3.78	Nominal	0.45	1.16	Other	525	806
25	NEU.EXC_NTNG1	3.44	Nominal	—	0.00	Other	0	0
26	EPI.ectocervical_granular	3.10	Nominal	—	0.55	Other	11	23
27	DC.cDC1	3.09	Nominal	0.15	1.34	Other	55	112
28	FIB.barrier_purinergic	3.02	Nominal	—	0.69	Other	1	3
29	EPI.skin_follicular_keratinizing	2.88	Nonsignificant	1.00	1.08	Other	30	81
30	EPI.skin_appendage_keratinocyte	2.83	Nonsignificant	1.00	0.93	Other	87	222
31	FIB.adventitial	2.77	Nonsignificant	1.11e-23	1.95	Other	268	1,447
32	GRANU.neutrophil	2.59	Nonsignificant	4.69e-04	1.71	Other	1,235	2,649
33	EPI.salivary_myoepithelial	2.40	Nonsignificant	1.00	1.01	Other	191	714
34	CM.cardiomyocyte	2.33	Nonsignificant	—	—	Other	524	2,032
35	THYMO.thymocyte	2.32	Nonsignificant	—	—	Other	163	495
36	MUSC.muscle_stem_cell	2.31	Nonsignificant	—	—	Other	4	18
37	FIB.neurolectin_mucosa	2.27	Nonsignificant	1.00	1.03	Other	133	394
38	EPI.esophageal_suprabasal	2.27	Nonsignificant	1.00	1.01	Other	158	404
39	MEL.melanocyte	2.11	Nonsignificant	—	—	Other	79	242
40	MAC.microglia_like	1.95	Nonsignificant	0.46	1.18	Other	124	179
41	T.CD4_Treg	1.87	Nonsignificant	1.26e-15	1.66	Other	244	511
42	ADIPO.adipocyte	1.78	Nonsignificant	—	—	Other	20	62
43	OLG.oligodendrocyte	1.69	Nonsignificant	—	—	Other	384	1,397
44	EPI.esophageal_basal	1.67	Nonsignificant	1.00	0.85	Other	4	10
45	DC.pDC	1.64	Nonsignificant	0.02	1.40	Other	496	1,028
46	PLAT.platelet	1.63	Nonsignificant	—	0.00	Other	38	53
47	SKM.type_1_slow	1.50	Nonsignificant	1.00	0.00	Other	923	2,478
48	PC.IgA_muocsal	1.47	Nonsignificant	0.39	1.20	Other	18	31
49	EPI.renal_principal_cell	1.34	Nonsignificant	1.00	0.76	Other	207	403
50	B.memory	1.33	Nonsignificant	1.58e-08	1.64	Other	442	882
51	EPI.salivary_serous_acinar	1.28	Nonsignificant	1.00	0.86	Other	233	531
52	ILC2.innate_lymphoid_cell_2	1.23	Nonsignificant	—	—	Other	2	0
53	FIB.tracheal_subepithelial	1.22	Nonsignificant	—	0.00	Other	0	0
54	EPI.colonic_tuft	1.12	Nonsignificant	—	0.27	Other	7	24
55	EPI.lung_club_secretory	1.07	Nonsignificant	1.00	0.86	Other	5	14
56	B.germinal_center	1.05	Nonsignificant	1.00	0.68	Other	233	655
57	EPI.renal_thick_ascending_limb	1.04	Nonsignificant	1.00	0.74	Other	453	1,153
58	PC.IgG_systemic	1.01	Nonsignificant	0.88	0.74	Other	41	60
59	FIB.interstitial	0.99	Nonsignificant	1.00	0.33	Other	288	940
60	B.naive	0.89	Nonsignificant	1.00	0.64	Other	307	595
61	ASPC.adipose_stem_and_progenitor_cell	0.86	Nonsignificant	—	—	Other	324	930
62	FIB.barrier_secretory	0.83	Nonsignificant	1.00	1.01	Other	81	228
63	IPSC.induced_pluripotent_stem_cell	0.82	Nonsignificant	—	—	Other	0	0
64	FIB.reticular	0.78	Nonsignificant	1.00	0.45	Other	19	87
65	DC.cDC2	0.76	Nonsignificant	1.00	0.59	Other	1,189	1,793
66	EPI.tracheal_submucosal_gland	0.69	Nonsignificant	—	0.07	Other	0	0
67	EPI.alveolar_type_2	0.67	Nonsignificant	1.00	0.72	Other	813	1,853
68	FIB.perivascular_interface	0.61	Nonsignificant	1.00	0.46	Other	0	0
69	MONO.CD14	0.49	Nonsignificant	0.83	1.02	Other	2,294	4,139
70	EC.capillary	0.45	Nonsignificant	2.97e-09	1.31	Other	514	1,635
71	EC.arterial	0.45	Nonsignificant	0.10	1.11	Other	356	885
72	ASTRO.astrocyte	0.44	Nonsignificant	—	—	Other	228	1,111
73	FIB.suburothelial	0.44	Nonsignificant	1.00	0.34	Other	122	432
74	MESO.mesothelial_cell	0.43	Nonsignificant	—	—	Other	2	18
75	EPI.ileal_enterocyte_crypt	0.42	Nonsignificant	1.00	0.69	Other	67	113
76	EPI.endocervical_secretory	0.42	Nonsignificant	—	0.00	Other	0	0
77	T.CD4_Trm	0.41	Nonsignificant	1.57e-03	1.25	Other	176	363
78	MONO.CD16	0.39	Nonsignificant	0.95	0.86	Other	1,304	1,835
79	GRANU.MAST	0.37	Nonsignificant	1.00	0.00	Other	5	6
80	T.CD4_Tcm	0.31	Nonsignificant	0.36	1.07	Other	494	988
81	T.CD4_transitional	0.31	Nonsignificant	0.64	1.08	Other	48	110
82	T.CD4_Tfh	0.29	Nonsignificant	0.69	1.05	Other	47	45
83	FIB.lung_alveolar	0.28	Nonsignificant	—	0.00	Other	6	15
84	T.CD4_naive	0.28	Nonsignificant	0.09	1.07	Other	399	866
85	FIB.transitioning	0.28	Nonsignificant	1.00	0.15	Other	172	497
86	T.CD4_Th17	0.27	Nonsignificant	1.00	0.92	Other	421	794
87	EPI.renal_distal_tubule	0.26	Nonsignificant	1.00	0.64	Other	133	361
88	T.CD8_Trm	0.24	Nonsignificant	0.69	1.04	Other	211	346
89	T.CD4_Tem	0.23	Nonsignificant	1.00	0.88	Other	365	697
90	EPI.gastric_foveolar	0.23	Nonsignificant	—	0.00	Other	0	0
91	MAC.MDM	0.15	Nonsignificant	1.00	1.03	Other	623	986
92	HPC.haematopoietic_progenitor_cell	0.14	Nonsignificant	—	—	Other	211	370
93	T.CD8_Tcm	0.14	Nonsignificant	1.00	0.72	Other	460	926
94	SMC.smooth_muscle_cell	0.13	Nonsignificant	—	—	Other	20	101
95	MAC.kupffer	0.12	Nonsignificant	1.00	1.02	Other	189	530
96	EC.venous	0.12	Nonsignificant	1.00	0.55	Other	516	1,387
97	FIB.skin_neurosecretory	0.11	Nonsignificant	—	0.00	Other	0	0
98	FIB.skin_sheath	0.11	Nonsignificant	1.00	0.11	Other	49	118
99	EPI.renal_intercalated_cell_type_A	0.11	Nonsignificant	1.00	0.60	Other	67	142
100	T.gamma_delta	0.10	Nonsignificant	4.49e-07	1.45	Other	588	1,078
101	EPI.colonic_enteroendocrine	0.10	Nonsignificant	—	0.00	Other	1	1
102	T.CD8_naive	0.09	Nonsignificant	1.00	0.52	Other	317	708
103	T.CD8_transitional	0.09	Nonsignificant	1.00	0.70	Other	497	932
104	CHOND.chondrocyte	0.09	Nonsignificant	—	—	Other	519	730
105	PERI.pericyte	0.08	Nonsignificant	—	—	Other	117	0
106	FIB.hepatic_stellate_cell	0.08	Nonsignificant	—	0.00	Other	64	252
107	EPI.thymic_medullary	0.08	Nonsignificant	1.00	0.51	Other	26	133
108	FIB.skin_papillary	0.08	Nonsignificant	—	0.00	Other	0	0
109	EPI.salivary_duct_ion_transport	0.07	Nonsignificant	1.00	0.51	Other	5	11
110	T.MAIT	0.07	Nonsignificant	1.00	0.50	Other	469	855
111	EPI.pancreatic_islet	0.06	Nonsignificant	1.00	0.72	Other	52	132
112	EPI.ileal_enterocyte_absorptive	0.05	Nonsignificant	1.00	0.49	Other	118	338
113	T.CD4_Th2	0.04	Nonsignificant	—	0.00	Other	1	2
114	EPI.renal_immature_ureteric_bud	0.04	Nonsignificant	1.00	0.41	Other	217	569
115	T.CD4_cytotoxic	0.04	Nonsignificant	1.00	0.65	Other	855	1,493
116	B.age_associated	0.03	Nonsignificant	1.00	0.11	Other	207	350
117	EC.heart_remodeling	0.03	Nonsignificant	1.00	0.26	Other	569	1,594
118	MAC.resident_iron	0.03	Nonsignificant	1.00	0.97	Other	16	21
119	EPI.renal_intercalated_cell_type_B	0.02	Nonsignificant	—	0.00	Other	6	7
120	EPI.ileal_bile_transport	0.02	Nonsignificant	1.00	0.42	Other	61	93
121	MG.microglia	0.02	Nonsignificant	—	—	Other	49	0
122	EPI.salivary_mucous_acinar	0.02	Nonsignificant	1.00	0.28	Other	639	1,189
123	HEP.pericentral_lipoprotein	0.02	Nonsignificant	—	2.41	Other	0	0
124	NK.natural_killer_cell	0.02	Nonsignificant	—	—	Other	1,204	2,045
125	EPI.alveolar_type_1	0.02	Nonsignificant	1.00	0.44	Other	26	101
126	T.CD8_Tem	0.02	Nonsignificant	1.00	0.31	Other	1,083	1,857
127	EPI.pancreatic_ductal_progenitor	0.01	Nonsignificant	1.00	0.39	Other	234	873
128	EPI.ileal_goblet	0.01	Nonsignificant	1.00	0.45	Other	181	432
129	EPI.pancreatic_ductal_perivascular	0.01	Nonsignificant	1.00	0.33	Other	4	30
130	EC.lymphatic	0.01	Nonsignificant	1.00	0.15	Other	630	998
131	EPI.pancreatic_ductal_bicarbonate	0.01	Nonsignificant	1.00	0.26	Other	131	548
132	FIB.skin_tenogenic	9.29e-03	Nonsignificant	—	0.00	Other	108	227
133	EPI.cervical_suprabasal	6.69e-03	Nonsignificant	—	0.00	Other	14	50
134	EC.liver_sinusoidal	6.49e-03	Nonsignificant	1.00	0.14	Other	1,083	1,925
135	EPI.pancreatic_ductal_mucinous	6.34e-03	Nonsignificant	1.00	0.35	Other	219	430
136	MAC.resident_repair	5.63e-03	Nonsignificant	1.00	0.96	Other	796	1,426
137	MAC.proliferating	5.01e-03	Nonsignificant	1.00	1.02	Other	87	253
138	MAC.LAM	4.36e-03	Nonsignificant	1.00	0.84	Other	914	2,064
139	EPI.intrahepatic_cholangiocyte_transport	2.32e-03	Nonsignificant	—	0.00	Other	12	42
140	DC.mig	2.10e-03	Nonsignificant	—	0.00	Other	89	156
141	MAC.resident_cardiac	1.89e-03	Nonsignificant	1.00	0.94	Other	485	1,074
142	EPI.extrahepatic_cholangiocyte	1.60e-03	Nonsignificant	—	0.00	Other	37	71
143	EPI.intrahepatic_cholangiocyte_defense	1.43e-03	Nonsignificant	—	0.00	Other	8	13
144	EPI.hepatic_ductular_cholangiocyte	1.39e-03	Nonsignificant	1.00	0.16	Other	83	243
145	EPI.pancreatic_acinar	1.03e-03	Nonsignificant	1.00	0.04	Other	429	1,475
146	HEP.periportal_metabolic	9.44e-04	Nonsignificant	0.19	1.02	Other	1,750	4,427
147	GRNLSA.granulosa_cell	9.39e-04	Nonsignificant	—	—	Other	257	0
148	MAC.alveolar	1.14e-04	Nonsignificant	1.00	0.72	Other	1,432	3,122
149	HEP.canalicular_transport	9.88e-05	Nonsignificant	1.00	0.96	Other	1,290	3,434
150	EPI.thymic_cortical	8.88e-05	Nonsignificant	1.00	0.24	Other	442	824
151	EPI.bile_duct_cholangiocyte	1.53e-05	Nonsignificant	1.00	0.02	Other	37	60
152	HEP.acute_phase	9.64e-06	Nonsignificant	1.00	0.85	Other	1,441	3,641

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_keratinocyte_basal.spinous_transition	26.05	Significant	—	0.97	—	0	0
2	NEU.INH_PVALB.fastspike	22.69	Significant	—	0.67	—	24	22
3	NEU.INH_PVALB.nuclear_reg	21.50	Significant	0.20	1.61	—	25	12
4	NEU.INH_PVALB.neuromodulatory	20.77	Significant	—	0.27	—	0	0
5	EPI.salivary_duct_excretory.stress	20.12	Significant	0.09	1.68	Specific	33	68
6	NEU.EXC_CT.Ca2_sensor	19.76	Significant	—	0.70	—	0	0
7	NEU.INH_PVALB.serotonergic	19.28	Significant	—	0.07	—	0	0
8	EPI.skin_keratinocyte_basal.transit_amplifying	18.97	Significant	—	0.00	Relevant	0	0
9	OPC.proliferative_immune_interact	18.97	Significant	0.53	1.17	Specific	180	373
10	NEU.EXC_CT.Ca2_signaling	18.44	Significant	—	0.59	—	68	17
11	NEU.INH_PVALB.metabotropic	18.42	Significant	—	0.00	—	0	0
12	OPC.homeostatic	18.32	Significant	0.53	1.32	—	394	160
13	EPI.salivary_intercalated_defense.basal_EMT	18.26	Significant	—	1.49	—	0	0
14	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	18.16	Significant	—	1.80	—	0	0
15	OPC.premyelinating	18.14	Significant	0.84	0.55	—	185	12
16	SCHWN.axon_contact_cardiac	17.36	Significant	0.20	1.51	Specific	18	63
17	NEU.INH_LAMP5.glial_interface	16.13	Significant	—	0.86	—	0	0
18	SCHWN.translation_boost	15.69	Significant	—	0.00	—	8	1
19	NEU.INH_VIP.matrix	15.24	Significant	—	0.96	—	24	77
20	NEU.INH_VIP.cannabinoid	14.99	Significant	—	0.79	—	0	0
21	EPI.salivary_intercalated_defense.inflammatory	14.43	Significant	0.06	1.57	Specific	152	360
22	NEU.EXC_CT.remodeling	14.31	Significant	—	0.00	—	23	1
23	EPI.salivary_duct_excretory.baseline	13.82	Significant	0.97	0.12	Specific	23	57
24	NEU.EXC_CT.projector	13.72	Significant	0.87	0.40	—	87	26
25	NEU.INH_VIP.develop_niche	13.70	Significant	—	0.45	—	0	0
26	EPI.skin_sebaceous_duct_luminal.detox_repair	13.59	Significant	2.52e-03	2.46	—	137	94
27	NEU.INH_VIP.opioid	13.58	Significant	—	0.54	—	50	9
28	NEU.INH_LAMP5.rosehip	13.12	Significant	—	0.00	—	0	0
29	EPI.skin_interfollicular_spinous.inflammatory	13.04	Significant	—	1.02	—	0	0
30	NEU.INH_LAMP5.exc_inh_balance	12.97	Significant	—	0.00	—	46	2
31	NEU.INH_VIP.excitatory_coupled	12.90	Significant	—	0.26	—	13	0
32	NEU.INH_LAMP5.projecting	12.80	Significant	—	0.00	—	0	0
33	SCHWN.reactive_inflammatory	12.39	Significant	—	0.00	—	0	0
34	NEU.INH_VIP.canonical_disinhibitory	12.36	Significant	0.57	0.92	—	59	38
35	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	11.75	Significant	—	1.15	Relevant	0	0
36	NEU.EXC_IT.adhesion	11.55	Significant	0.20	1.61	—	252	108
37	NEU.INH_PVALB.chandelier	11.45	Significant	1.00	0.00	—	19	16
38	NEU.INH_VIP.nuclear_reg	11.37	Significant	—	0.00	—	20	4
39	EPI.skin_interfollicular_spinous.proliferative	11.19	Significant	—	0.52	—	0	0
40	NEU.EXC_SYT2.nuclear_reg	11.11	Significant	—	0.97	—	0	0
41	EPI.skin_interfollicular_spinous.early_differentiation	10.84	Significant	0.14	1.64	—	89	19
42	NEU.EXC_IT.neuromodulated	10.51	Significant	0.20	1.77	—	176	116
43	EPI.skin_interfollicular_spinous.stress_oxidative	10.44	Significant	—	0.14	—	0	0
44	EPI.skin_interfollicular_spinous.transition_basal	10.32	Significant	0.14	1.71	—	100	127
45	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	10.07	Significant	—	0.42	—	0	0
46	NEU.INH_VIP.serotonergic	9.96	Significant	—	0.00	—	9	2
47	NEU.EXC_IT.transitional	9.89	Significant	0.36	1.33	—	237	142
48	NEU.INH_VIP.regulatory_remodeling	9.77	Significant	—	0.00	—	6	1
49	EPI.skin_sweat_duct_keratinocyte.signal_gate	9.68	Significant	—	0.35	—	43	26
50	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	9.38	Significant	—	1.57	Specific	39	82
51	EPI.skin_keratinocyte_basal.basement_anchoring	9.32	Significant	—	0.00	Relevant	0	0
52	NEU.EXC_IT.callosal	9.07	Significant	0.36	1.27	—	286	119
53	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	9.01	Significant	—	0.00	Relevant	0	0
54	EPI.skin_interfollicular_spinous.stress_UPR	8.99	Significant	—	0.00	—	0	0
55	EPI.skin_keratinocyte_proliferating.early_spinous_transition	8.95	Significant	—	0.49	Relevant	135	290
56	EPI.skin_hair_follicle_companion.activated_migratory	8.84	Significant	—	0.97	—	0	0
57	EPI.skin_sweat_duct_keratinocyte.repair	8.71	Significant	—	0.10	—	0	0
58	EPI.skin_interfollicular_spinous.baseline	8.68	Significant	0.94	0.28	—	35	3
59	EPI.tracheal_suprabasal.transitional_wound	8.65	Significant	—	0.60	—	16	1
60	EPI.skin_hair_follicle_companion.gap_junction_contractile	8.63	Significant	—	0.00	—	0	0
61	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	8.43	Significant	1.00	0.00	Relevant	2	9
62	DC.cDC1.homeostatic_inhibitory	8.19	Significant	—	1.21	Relevant	0	0
63	NEU.EXC_IT.guidance	8.17	Significant	0.64	0.97	—	274	63
64	EPI.colonocyte.crypt_progenitor	8.10	Significant	5.84e-04	2.01	Specific	115	265
65	EPI.skin_keratinocyte_progenitor.activated_stress	8.02	Significant	—	0.00	Relevant	0	0
66	EPI.skin_sebaceous_duct_luminal.immune_interface	7.95	Significant	—	0.00	Relevant	0	0
67	SKM.type_2_fast.glycolytic_IIx_IIb	7.93	Significant	0.44	1.04	Specific	565	1,482
68	NEU.INH_VIP.LAMP5_hybrid	7.88	Significant	—	0.00	—	1	9
69	SKM.type_2_fast.oxidative_IIa	7.66	Significant	0.44	1.09	—	946	56
70	EPI.skin_sweat_duct_keratinocyte.barrier	7.63	Significant	—	0.00	—	0	0
71	EPI.skin_hair_follicle_bulge.niche_crosstalk	7.58	Significant	—	1.32	Specific	29	88
72	EPI.skin_sweat_duct_keratinocyte.proliferative_S	7.46	Significant	—	0.00	—	0	0
73	EPI.skin_keratinocyte_proliferating.detox_repair	7.21	Significant	—	0.00	—	0	0
74	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	7.06	Significant	—	0.00	Relevant	0	0
75	EPI.colonocyte.junction_remodeling	6.54	Significant	0.99	0.86	Relevant	218	305
76	NEU.EXC_SYT2.synaptic	6.39	Significant	—	0.00	—	0	0
77	NEU.INH_VIP.enkephalinergic	6.19	Significant	—	0.00	—	0	0
78	EPI.lung_multiciliated.stress	5.74	Significant	—	0.52	Relevant	67	165
79	EPI.colonocyte.proximal_transport	5.64	Significant	0.99	0.58	Other	24	12
80	EPI.tracheal_basal.homeostatic_progenitor	5.63	Significant	0.83	0.93	—	285	74
81	EPI.tracheal_suprabasal.secretory_immune	5.60	Significant	—	0.00	Relevant	0	0
82	EPI.tracheal_basal.activated_stress	5.34	Nominal	0.83	0.50	Other	32	0
83	EPI.colonocyte.goblet_interface	5.09	Nominal	—	0.00	Other	11	21
84	EPI.skin_interfollicular_spinous.upper_lipid	4.97	Nominal	—	0.00	Other	6	6
85	NEU.EXC_IT.structural	4.94	Nominal	1.00	0.00	Other	171	41
86	EPI.lung_multiciliated.baseline	4.78	Nominal	—	0.00	Other	0	7
87	EPI.esophageal_suprabasal.proliferative_exit	4.60	Nominal	—	2.10	Other	0	0
88	EPI.ectocervical_granular.proliferative_basal	4.57	Nominal	—	1.15	Other	0	0
89	EPI.salivary_intercalated_defense.canonical_antimicrobial	4.42	Nominal	0.96	0.38	Other	11	22
90	EPI.skin_keratinocyte_proliferating.anchor_remodel	4.37	Nominal	—	0.00	Other	0	0
91	EPI.skin_hair_follicle_bulge.quiescent	4.23	Nominal	0.77	0.60	Other	56	69
92	EPI.renal_proximal_tubule.detox_antioxidant	4.14	Nominal	7.66e-03	2.47	Other	394	77
93	EPI.lung_club_secretory.ciliogenesis_axoneme	4.10	Nominal	—	1.13	Other	0	0
94	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	4.06	Nominal	—	0.00	Other	0	0
95	MEL.stress_glucocorticoid	4.06	Nominal	0.46	1.04	Other	11	34
96	PLAT.megakaryocytic	3.89	Nominal	—	0.97	Other	0	0
97	FIB.adventitial.mito_secretory	3.82	Nominal	0.20	1.68	Other	21	7
98	EPI.salivary_serous_acinar.quiescent	3.81	Nominal	9.58e-09	2.40	Other	178	493
99	ADIPO.thermogenic	3.75	Nominal	—	1.09	Other	0	0
100	NEU.EXC_NTNG1.nuclear_reg	3.73	Nominal	—	0.67	Other	0	0
101	MAC.microglia_like.inflammatory_chemokine	3.72	Nominal	—	0.61	Other	20	32
102	ASPC.mesothelial_like	3.70	Nominal	0.02	1.82	Other	143	486
103	EPI.skin_follicular_keratinizing.transit_amplifying	3.49	Nominal	—	0.26	Other	21	49
104	FIB.adventitial.baseline	3.40	Nominal	0.21	1.40	Other	157	278
105	MONO.CD14.cord_tolerance	3.30	Nominal	1.38e-16	1.84	Other	864	753
106	EPI.renal_proximal_tubule.onecarbon_peroxisome	3.28	Nominal	0.69	0.63	Other	58	89
107	FIB.adventitial.complement_angiocrine	3.23	Nominal	0.24	1.31	Other	153	684
108	THYMO.DP_early	3.13	Nominal	3.14e-03	1.80	Other	326	313
109	NEU.EXC_NTNG1.synaptic	3.11	Nominal	—	0.00	Other	0	0
110	EPI.colonocyte.secretory_boost	3.06	Nominal	0.99	0.34	Other	98	91
111	OLG.myelinating_mature	3.04	Nominal	7.19e-11	1.50	Other	363	94
112	FIB.barrier_purinergic.stress_GF_binding	3.02	Nominal	—	0.00	Other	0	0
113	FIB.barrier_purinergic.lipid_secretory	3.02	Nominal	—	0.00	Other	0	0
114	CM.mito_proteostasis	3.01	Nominal	9.07e-03	1.69	Other	329	29
115	CM.anti_inflammatory	2.99	Nonsignificant	0.10	1.46	Other	424	1,503
116	FIB.adventitial.mechano_chemo_sensing	2.95	Nonsignificant	0.48	1.16	Other	135	524
117	OLG.myelinating_stress	2.94	Nonsignificant	0.40	1.12	Other	232	62
118	CM.sarcomere_actin_interface	2.91	Nonsignificant	8.56e-03	1.75	Other	450	78
119	FIB.neurolectin_mucosa.inflammatory	2.87	Nonsignificant	0.20	1.56	Other	52	110
120	GRANU.neutrophil.tissue_patrolling	2.83	Nonsignificant	—	0.52	Other	0	0
121	EPI.renal_thick_ascending_limb.canonical_salt_transporter	2.78	Nonsignificant	1.24e-04	1.54	Other	322	317
122	FIB.neurolectin_mucosa.axon_responsive	2.75	Nonsignificant	0.47	1.02	Other	10	10
123	GRANU.neutrophil.primed_degranulation	2.75	Nonsignificant	—	0.38	Other	0	0
124	EPI.esophageal_suprabasal.basal_transitional	2.69	Nonsignificant	0.03	2.14	Other	44	67
125	THYMO.SP_CD8_naive	2.69	Nonsignificant	0.23	1.33	Other	297	177
126	IPSC.canonical_pluripotent	2.68	Nonsignificant	3.84e-06	1.32	Other	0	0
127	FIB.adventitial.PI16_matrix	2.66	Nonsignificant	1.00	0.65	Other	70	90
128	EPI.skin_follicular_keratinizing.root_infundibulum	2.65	Nonsignificant	—	0.00	Other	0	0
129	THYMO.SP_CD4_naive	2.61	Nonsignificant	0.71	1.06	Other	65	75
130	CM.osmoprotection	2.61	Nonsignificant	0.83	1.09	Other	34	57
131	EPI.lung_multiciliated.mature_motile_cilia	2.61	Nonsignificant	—	0.00	Other	0	0
132	CM.oxidative_phospho	2.60	Nonsignificant	0.83	1.05	Other	266	792
133	MUSC.quiescent_reservoir	2.56	Nonsignificant	0.52	1.12	Other	2	8
134	DC.cDC1.activated	2.55	Nonsignificant	—	0.32	Other	0	0
135	EPI.salivary_myoepithelial.junctional_transport	2.55	Nonsignificant	0.48	1.49	Other	66	121
136	EPI.salivary_myoepithelial.activated	2.55	Nonsignificant	0.48	1.21	Other	85	281
137	EPI.skin_follicular_keratinizing.upper_infundibulum	2.51	Nonsignificant	—	0.00	Other	8	2
138	CM.translation_boost_RPL	2.49	Nonsignificant	1.00	0.89	Other	129	1
139	ADIPO.hypoxia_remodelling	2.44	Nonsignificant	—	0.42	Other	29	105
140	MUSC.activated_migratory	2.42	Nonsignificant	0.52	1.31	Other	6	7
141	EPI.salivary_myoepithelial.contractile_repair	2.42	Nonsignificant	—	0.00	Other	3	9
142	MEL.secretory_quiescent	2.38	Nonsignificant	0.46	1.10	Other	19	13
143	EPI.esophageal_suprabasal.proliferative_S	2.34	Nonsignificant	—	0.42	Other	26	41
144	T.CD4_Treg.APC_interactive	2.33	Nonsignificant	8.49e-03	1.78	Other	118	28
145	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	2.32	Nonsignificant	0.98	1.06	Other	33	34
146	MUSC.early_activation	2.30	Nonsignificant	0.52	1.20	Other	4	32
147	EPI.esophageal_suprabasal.proliferative_G2M	2.27	Nonsignificant	—	0.41	Other	0	0
148	GRANU.neutrophil.antiviral_endotoxin	2.25	Nonsignificant	—	0.00	Other	0	0
149	EPI.ectocervical_granular.secretory_apocrine	2.21	Nonsignificant	—	0.32	Other	0	0
150	EPI.salivary_myoepithelial.baseline	2.18	Nonsignificant	0.93	0.33	Other	42	141
151	EPI.skin_hair_follicle_bulge.anagen_growth	2.16	Nonsignificant	—	0.00	Other	0	0
152	EPI.renal_principal_cell.activated_acute	2.08	Nonsignificant	0.16	1.68	Other	29	59
153	EPI.esophageal_basal.junctional_barrier	2.08	Nonsignificant	—	1.01	Other	0	0
154	CM.translation_boost_RPS	2.06	Nonsignificant	1.00	0.76	Other	69	16
155	DC.pDC.immature_metabolic	2.04	Nonsignificant	0.73	1.01	Other	78	124
156	DC.pDC.baseline	2.04	Nonsignificant	0.73	1.12	Other	88	123
157	OLG.vesicle_trafficking	2.03	Nonsignificant	1.00	1.01	Other	124	10
158	MUSC.baseline	2.02	Nonsignificant	0.81	0.63	Other	0	0
159	EPI.esophageal_suprabasal.differentiating_keratin	2.01	Nonsignificant	0.94	0.33	Other	131	61
160	T.CD4_Treg.Tr1_like	1.94	Nonsignificant	—	0.08	Other	8	8
161	SKM.type_1_slow.glycolytic	1.91	Nonsignificant	8.60e-03	2.21	Other	362	647
162	CM.baseline	1.91	Nonsignificant	1.00	0.33	Other	393	0
163	FIB.interstitial.remodeling	1.91	Nonsignificant	6.29e-05	1.61	Other	31	9
164	FIB.adventitial.inflammatory_activated	1.91	Nonsignificant	1.00	0.09	Other	100	473
165	MEL.neurotrophic_migratory	1.89	Nonsignificant	—	0.32	Other	0	0
166	B.germinal_center.DZ_M_phase	1.84	Nonsignificant	—	1.47	Other	0	0
167	ILC2.activated	1.82	Nonsignificant	—	0.44	Other	0	0
168	PC.IgG_systemic.metabolic	1.80	Nonsignificant	0.20	1.42	Other	46	63
169	EPI.colonocyte.ionocyte_BEST4	1.78	Nonsignificant	0.99	0.34	Other	103	188
170	PC.IgA_muocsal.migratory	1.77	Nonsignificant	0.32	1.19	Other	4	1
171	THYMO.SP_CD8_naive_stress	1.76	Nonsignificant	1.00	0.72	Other	1	1
172	EPI.ectocervical_granular.immune_interact	1.73	Nonsignificant	—	0.00	Other	0	0
173	B.naive.activated	1.71	Nonsignificant	3.75e-03	1.75	Other	77	127
174	FIB.adventitial.adhesion_lipid	1.65	Nonsignificant	1.00	0.38	Other	58	209
175	FIB.neurolectin_mucosa.remodeling_repair	1.64	Nonsignificant	—	0.00	Other	4	2
176	FIB.neurolectin_mucosa.nerve_interface	1.62	Nonsignificant	—	0.00	Other	4	0
177	EPI.skin_appendage_keratinocyte.transit_amplifying	1.61	Nonsignificant	—	0.00	Other	109	358
178	DC.cDC1.cross_presenting	1.61	Nonsignificant	—	0.00	Other	0	0
179	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	1.57	Nonsignificant	0.98	0.15	Other	7	16
180	B.memory.activated	1.56	Nonsignificant	0.35	1.24	Other	105	29
181	DC.cDC2.tolerogenic_regulatory	1.55	Nonsignificant	0.56	1.27	Other	44	4
182	EPI.esophageal_basal.activated_progenitor	1.53	Nonsignificant	1.00	0.00	Other	1	0
183	CM.mechano_activated	1.53	Nonsignificant	1.00	0.38	Other	205	134
184	THYMO.proliferative_S	1.53	Nonsignificant	0.40	1.27	Other	163	418
185	PC.IgA_muocsal.plasmablast	1.50	Nonsignificant	0.32	1.32	Other	5	4
186	T.CD4_Treg.central_naive_like	1.50	Nonsignificant	1.00	0.61	Other	333	45
187	DC.cDC2.monocyte_like	1.48	Nonsignificant	0.16	1.49	Other	1,285	791
188	IPSC.mesendo_primed	1.41	Nonsignificant	0.04	1.14	Other	0	0
189	B.memory.baseline	1.41	Nonsignificant	0.35	1.22	Other	472	99
190	SKM.type_1_slow.oxidative	1.41	Nonsignificant	0.78	0.97	Other	802	251
191	DC.cDC1.baseline	1.40	Nonsignificant	—	0.00	Other	0	0
192	EPI.renal_distal_tubule.ion_transport	1.39	Nonsignificant	—	1.34	Other	0	0
193	FIB.adventitial.activated_remodelling	1.39	Nonsignificant	—	0.00	Other	141	319
194	T.CD4_Trm.activated	1.37	Nonsignificant	0.33	1.33	Other	32	26
195	THYMO.CD8aa_IELp	1.37	Nonsignificant	—	0.00	Other	1	7
196	EPI.renal_principal_cell.injury_repair	1.37	Nonsignificant	0.95	0.99	Other	26	9
197	SKM.type_1_slow.contractile	1.36	Nonsignificant	0.99	0.11	Other	596	8
198	EPI.renal_principal_cell.intercalated_like	1.36	Nonsignificant	0.95	0.93	Other	63	66
199	B.memory.pDC_imprint	1.33	Nonsignificant	0.99	0.66	Other	157	103
200	PC.IgA_muocsal.baseline	1.32	Nonsignificant	0.77	0.97	Other	3	5
201	B.naive.receptor_recycle	1.29	Nonsignificant	0.28	1.34	Other	51	0
202	FIB.interstitial.immune_interact	1.29	Nonsignificant	0.96	1.08	Other	12	1
203	B.germinal_center.DZ_S_phase	1.28	Nonsignificant	—	0.58	Other	0	0
204	IPSC.stromal_primed	1.27	Nonsignificant	1.00	1.02	Other	0	0
205	PC.IgA_muocsal.activated	1.27	Nonsignificant	0.88	0.78	Other	17	8
206	EPI.tracheal_submucosal_gland.ductal_luminal	1.25	Nonsignificant	—	0.73	Other	0	0
207	ASPC.niche_keeping_progenitor	1.25	Nonsignificant	0.06	1.47	Other	52	219
208	B.memory.migratory	1.24	Nonsignificant	0.63	1.07	Other	123	208
209	ASPC.baseline	1.23	Nonsignificant	1.92e-04	1.46	Other	363	170
210	FIB.tracheal_subepithelial.baseline	1.22	Nonsignificant	—	0.00	Other	0	0
211	ASTRO.homeostatic	1.20	Nonsignificant	0.04	1.37	Other	200	431
212	EPI.colonic_tuft.homeostatic	1.15	Nonsignificant	—	0.00	Other	0	0
213	OLG.stress	1.11	Nonsignificant	1.00	0.74	Other	232	8
214	B.naive.baseline	1.11	Nonsignificant	0.28	1.34	Other	10	13
215	EPI.colonic_tuft.activated	1.10	Nonsignificant	—	0.00	Other	0	0
216	EPI.salivary_serous_acinar.secretory_active	1.09	Nonsignificant	0.98	0.45	Other	242	69
217	EPI.ectocervical_granular.inflammatory	1.08	Nonsignificant	—	0.00	Other	0	0
218	MEL.mature_oxidative_traffic	1.08	Nonsignificant	0.46	1.15	Other	247	285
219	ILC2.quiescent	1.05	Nonsignificant	—	0.00	Other	0	0
220	FIB.barrier_secretory.homeostasis	1.05	Nonsignificant	—	0.00	Other	0	0
221	B.naive.purinergic	1.04	Nonsignificant	0.45	1.13	Other	384	820
222	EPI.alveolar_type_2.stress_response	1.03	Nonsignificant	1.33e-03	1.68	Other	675	1,562
223	EPI.renal_thick_ascending_limb.cation_flux	0.98	Nonsignificant	1.00	0.93	Other	57	95
224	FIB.reticular.stromal_niche	0.93	Nonsignificant	0.31	1.21	Other	0	0
225	ASPC.signal_integrator	0.92	Nonsignificant	—	0.22	Other	0	0
226	B.naive.metabolic	0.91	Nonsignificant	1.00	0.76	Other	50	79
227	B.germinal_center.LZ_survival	0.89	Nonsignificant	—	0.00	Other	0	0
228	FIB.interstitial.mesenchymal_APC	0.87	Nonsignificant	1.00	0.83	Other	81	33
229	FIB.reticular.stress_metallothionein	0.86	Nonsignificant	—	0.31	Other	3	32
230	T.CD4_Tcm.APC_mimicry	0.86	Nonsignificant	0.02	1.72	Other	54	43
231	ASPC.adipocyte_capillary_interface	0.85	Nonsignificant	0.97	1.12	Other	21	54
232	EC.arterial.metabolic	0.84	Nonsignificant	4.38e-03	1.48	Other	195	159
233	PC.IgG_systemic.secretory	0.84	Nonsignificant	0.87	0.63	Other	0	0
234	DC.cDC1.proliferative	0.83	Nonsignificant	—	0.00	Other	0	0
235	B.naive.remodeling	0.83	Nonsignificant	1.00	0.66	Other	135	230
236	OLG.reactive_repair	0.83	Nonsignificant	1.00	0.69	Other	385	385
237	ILC2.migratory	0.82	Nonsignificant	—	0.00	Other	0	0
238	EPI.renal_principal_cell.inflammatory	0.81	Nonsignificant	0.98	0.46	Other	74	157
239	IPSC.axial_identity_primed	0.81	Nonsignificant	1.00	1.00	Other	0	0
240	B.germinal_center.LZ_memory_precursor	0.80	Nonsignificant	—	0.00	Other	0	0
241	T.CD4_Treg.tissue_effector	0.80	Nonsignificant	1.00	0.20	Other	16	13
242	THYMO.DN_preTCR	0.80	Nonsignificant	1.00	0.23	Other	41	71
243	ASPC.inflammatory	0.79	Nonsignificant	0.98	1.03	Other	21	61
244	EPI.renal_principal_cell.canonical_vasopressin	0.78	Nonsignificant	0.98	0.29	Other	2	0
245	EPI.ileal_enterocyte_crypt.proliferative_S	0.77	Nonsignificant	0.54	1.24	Other	4	2
246	B.naive.proteostasis	0.77	Nonsignificant	1.00	0.91	Other	49	69
247	DC.pDC.poised_migratory	0.76	Nonsignificant	0.96	0.50	Other	54	95
248	EPI.alveolar_type_2.baseline_surfactant	0.74	Nonsignificant	1.00	0.87	Other	64	9
249	B.naive.antigen_presenting_ready	0.74	Nonsignificant	1.00	0.82	Other	48	73
250	GRANU.MAST.activated_acute	0.73	Nonsignificant	—	0.80	Other	0	0
251	FIB.perivascular_interface.lipid_shuttle	0.72	Nonsignificant	—	0.73	Other	51	170
252	MEL.dedifferentiated_migratory	0.72	Nonsignificant	—	0.00	Other	0	0
253	ASPC.preadipocyte_lipid_primed	0.70	Nonsignificant	1.00	0.82	Other	331	129
254	PC.IgG_systemic.interacting	0.70	Nonsignificant	0.87	0.82	Other	0	0
255	T.CD4_Trm.baseline	0.69	Nonsignificant	0.10	1.24	Other	31	21
256	ASTRO.A2_reactive	0.68	Nonsignificant	1.00	1.02	Other	10	37
257	T.CD4_transitional.tissue_enagement	0.67	Nonsignificant	0.15	1.40	Other	5	11
258	T.CD8_Trm.inflammatory	0.67	Nonsignificant	1.81e-04	1.41	Other	124	176
259	T.CD4_naive.Treg_like	0.67	Nonsignificant	0.07	1.74	Other	121	72
260	EC.capillary.activated	0.67	Nonsignificant	0.12	1.55	Other	2	5
261	DC.cDC2.adhesion_signaling	0.66	Nonsignificant	0.98	0.98	Other	35	9
262	MESO.activated_stress	0.66	Nonsignificant	—	0.00	Other	0	0
263	FIB.reticular.immune_interface	0.66	Nonsignificant	—	0.00	Other	1	6
264	T.CD4_transitional.APC_interacting	0.65	Nonsignificant	0.15	1.39	Other	10	14
265	EC.arterial.inflammatory	0.65	Nonsignificant	0.10	1.36	Other	63	50
266	EC.capillary.postcap_venule	0.63	Nonsignificant	9.52e-04	1.67	Other	355	261
267	EC.arterial.elastic	0.62	Nonsignificant	4.07e-03	1.52	Other	22	45
268	B.germinal_center.LZ_selection	0.61	Nonsignificant	—	0.00	Other	0	0
269	FIB.perivascular_interface.vascular_BM_remodelling	0.60	Nonsignificant	—	0.00	Other	0	0
270	THYMO.proliferative_G2M	0.60	Nonsignificant	—	0.00	Other	164	413
271	ASTRO.immature_lipid	0.60	Nonsignificant	0.87	1.15	Other	23	113
272	ASPC.activated	0.59	Nonsignificant	1.00	0.51	Other	164	162
273	EPI.endocervical_secretory.secretory_translocon	0.58	Nonsignificant	—	0.67	Other	0	0
274	EC.capillary.migratory	0.56	Nonsignificant	0.78	1.10	Other	181	509
275	MAC.microglia_like.phagocytic_redox	0.56	Nonsignificant	—	0.00	Other	0	0
276	FIB.interstitial.mesenchymal_regulator	0.56	Nonsignificant	1.00	0.50	Other	4	4
277	IPSC.endoderm_primed	0.56	Nonsignificant	1.00	0.97	Other	0	0
278	B.memory.preactivated	0.55	Nonsignificant	0.99	0.47	Other	173	174
279	FIB.transitioning.motility_remodelling	0.55	Nonsignificant	—	0.85	Other	0	0
280	MESO.secretory_structural	0.54	Nonsignificant	—	0.47	Other	0	0
281	MONO.CD16.inflammatory	0.54	Nonsignificant	0.04	1.39	Other	1,640	168
282	T.CD4_naive.gut_prone	0.53	Nonsignificant	0.94	1.23	Other	35	70
283	FIB.barrier_secretory.remodeling	0.53	Nonsignificant	—	0.00	Other	0	0
284	T.CD4_Tfh.precursor_migratory	0.53	Nonsignificant	0.03	1.46	Other	72	27
285	EC.venous.adipose_lipid	0.52	Nonsignificant	0.07	1.33	Other	254	476
286	EC.arterial.mito_contact	0.52	Nonsignificant	0.78	1.09	Other	14	5
287	MONO.CD16.baseline	0.51	Nonsignificant	0.16	1.34	Other	50	1
288	FIB.suburothelial.urothelial_interface	0.51	Nonsignificant	4.03e-03	2.21	Other	9	8
289	MESO.activated_migratory	0.51	Nonsignificant	—	2.22e-16	Other	0	0
290	DC.cDC2.migratory	0.50	Nonsignificant	0.99	0.84	Other	185	39
291	ASPC.remodeling	0.49	Nonsignificant	1.00	0.42	Other	106	354
292	EC.capillary.angiocrine	0.49	Nonsignificant	0.78	1.06	Other	250	630
293	ASPC.secretory	0.48	Nonsignificant	1.00	0.32	Other	76	5
294	FIB.suburothelial.homeostasis_matrix	0.48	Nonsignificant	0.25	1.35	Other	258	921
295	MONO.CD14.baseline	0.48	Nonsignificant	0.79	1.04	Other	2,268	76
296	ASTRO.synaptic_interaction	0.47	Nonsignificant	1.00	0.92	Other	76	334
297	FIB.perivascular_interface.vasomotor_tone	0.47	Nonsignificant	—	0.00	Other	0	0
298	T.CD4_Th17.migratory	0.47	Nonsignificant	0.29	1.42	Other	13	23
299	EPI.ileal_enterocyte_crypt.baseline	0.46	Nonsignificant	0.72	1.00	Other	11	6
300	EC.capillary.baseline	0.46	Nonsignificant	0.86	0.99	Other	246	560
301	THYMO.SP_CD8_transitional	0.46	Nonsignificant	1.00	0.15	Other	32	75
302	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.45	Nonsignificant	—	0.30	Other	19	54
303	FIB.interstitial.stress_secretory	0.45	Nonsignificant	1.00	0.54	Other	92	56
304	GRANU.MAST.resting_granule	0.43	Nonsignificant	—	0.61	Other	0	0
305	EPI.renal_intercalated_cell_type_A.PC_transitional	0.43	Nonsignificant	—	0.69	Other	203	407
306	T.CD4_Tcm.Tfh_like	0.42	Nonsignificant	0.30	1.35	Other	102	214
307	T.CD8_transitional.stress	0.42	Nonsignificant	—	0.88	Other	24	34
308	FIB.transitioning.secretory_procollagen	0.41	Nonsignificant	—	0.66	Other	0	0
309	T.CD4_Trm.stress_adaptive	0.41	Nonsignificant	1.00	0.97	Other	8	22
310	HPC.MPP_activated	0.40	Nonsignificant	—	1.05	Other	0	0
311	MONO.CD14.APC_like	0.40	Nonsignificant	1.00	0.81	Other	1,686	2,493
312	EPI.renal_thick_ascending_limb.barrier_repair	0.40	Nonsignificant	1.00	0.57	Other	141	284
313	ADIPO.immature	0.39	Nonsignificant	—	0.00	Other	24	40
314	T.CD4_Tcm.migratory_cilium	0.39	Nonsignificant	0.33	1.37	Other	5	10
315	ASTRO.stress_mito	0.39	Nonsignificant	1.00	0.81	Other	47	110
316	MESO.antiviral	0.39	Nonsignificant	—	0.00	Other	3	8
317	DC.cDC2.antiviral	0.38	Nonsignificant	0.99	0.69	Other	100	37
318	T.CD4_Tcm.Th2_like	0.36	Nonsignificant	0.30	1.44	Other	23	55
319	T.CD4_Tcm.regulatory_poised	0.36	Nonsignificant	0.95	1.05	Other	2	3
320	MAC.kupffer.tolerogenic	0.36	Nonsignificant	—	1.32	Other	45	49
321	FIB.lung_alveolar.mito_secretory	0.36	Nonsignificant	—	0.48	Other	0	0
322	FIB.reticular.ECM_builder	0.36	Nonsignificant	—	0.00	Other	0	0
323	EC.capillary.stress	0.35	Nonsignificant	0.99	0.63	Other	44	36
324	EC.capillary.inflammatory	0.35	Nonsignificant	0.99	0.66	Other	27	51
325	FIB.suburothelial.contractile_myofibroblast	0.34	Nonsignificant	—	0.00	Other	9	0
326	T.CD4_naive.homeostatic	0.33	Nonsignificant	0.94	0.94	Other	215	108
327	PLAT.adhesion	0.32	Nonsignificant	—	0.00	Other	0	0
328	T.CD4_Tcm.DC_interact	0.32	Nonsignificant	0.85	1.14	Other	72	32
329	MONO.CD14.platelet_bound	0.31	Nonsignificant	1.00	0.96	Other	964	176
330	MONO.CD14.remodeling	0.31	Nonsignificant	1.00	0.60	Other	2,373	295
331	T.CD4_Tem.inflammatory	0.31	Nonsignificant	0.43	1.17	Other	28	6
332	EC.arterial.arteriole_gas_exchange	0.30	Nonsignificant	0.99	0.66	Other	238	131
333	T.CD4_Tcm.stress	0.30	Nonsignificant	0.95	0.89	Other	5	11
334	HPC.MEP	0.30	Nonsignificant	0.22	1.23	Other	599	1,195
335	T.CD4_naive.mature	0.30	Nonsignificant	0.94	0.99	Other	211	100
336	OLG.regulatory_activated	0.30	Nonsignificant	1.00	0.37	Other	196	614
337	T.CD4_Tem.transitional_CM	0.29	Nonsignificant	0.43	1.16	Other	31	20
338	EC.arterial.arteriole_interface	0.29	Nonsignificant	0.99	0.77	Other	31	12
339	MONO.CD16.patrolling	0.29	Nonsignificant	1.00	0.55	Other	797	216
340	EPI.ileal_enterocyte_crypt.bile_transport	0.29	Nonsignificant	0.88	0.70	Other	2	0
341	MESO.baseline	0.28	Nonsignificant	0.87	0.61	Other	0	6
342	T.CD4_naive.proteostasis	0.28	Nonsignificant	0.94	1.02	Other	14	9
343	MONO.CD16.platelet_bound	0.28	Nonsignificant	0.30	1.28	Other	372	508
344	T.CD4_naive.mature_mitoprot	0.28	Nonsignificant	0.94	1.11	Other	212	476
345	MAC.MDM.inflammatory_phagocytic	0.28	Nonsignificant	0.41	1.21	Other	199	52
346	T.CD4_Tcm.baseline	0.28	Nonsignificant	0.95	0.96	Other	61	31
347	NK.cytokine_lung_immediate_early	0.27	Nonsignificant	0.53	1.22	Other	424	274
348	T.CD4_Tcm.effector_like	0.27	Nonsignificant	0.95	0.85	Other	293	533
349	T.CD4_naive.neddylation	0.27	Nonsignificant	0.94	0.84	Other	104	222
350	T.CD4_naive.survival_neddylation	0.27	Nonsignificant	0.94	0.89	Other	26	38
351	CHOND.angiogenic	0.27	Nonsignificant	—	1.29	Other	0	0
352	T.CD4_Tcm.imprinted_splicing	0.27	Nonsignificant	0.95	0.94	Other	6	17
353	EPI.renal_thick_ascending_limb.salt_sensing	0.26	Nonsignificant	1.00	0.48	Other	73	103
354	EPI.lung_club_secretory.ciliogenesis_primed	0.26	Nonsignificant	—	0.37	Other	0	0
355	T.CD4_Trm.cytotoxic_effector	0.26	Nonsignificant	0.76	1.07	Other	118	77
356	MAC.MDM.APC_dendritic	0.26	Nonsignificant	0.96	1.06	Other	48	15
357	T.CD8_Tcm.baseline	0.26	Nonsignificant	0.49	1.23	Other	90	89
358	FIB.transitioning.matrix_stress	0.26	Nonsignificant	—	0.06	Other	47	138
359	MONO.CD16.hepatic_mac_like	0.26	Nonsignificant	0.60	1.03	Other	803	117
360	T.CD4_Tcm.synapse_dynamics	0.25	Nonsignificant	0.95	1.05	Other	15	10
361	CHOND.pro_inflammatory	0.25	Nonsignificant	0.03	1.33	Other	181	351
362	T.CD4_transitional.baseline	0.25	Nonsignificant	0.98	0.70	Other	59	97
363	T.CD4_naive.neddylation_mitoprot	0.25	Nonsignificant	0.94	0.97	Other	93	56
364	B.naive.restrained	0.24	Nonsignificant	1.00	0.09	Other	183	353
365	ASTRO.hypoxia_angiogenic	0.24	Nonsignificant	1.00	0.85	Other	5	18
366	EPI.renal_thick_ascending_limb.remodeling	0.24	Nonsignificant	1.00	0.33	Other	152	92
367	T.CD4_Tcm.crosstalk_myeloid	0.24	Nonsignificant	0.95	0.79	Other	5	4
368	T.CD4_Tcm.secretory	0.23	Nonsignificant	0.95	0.86	Other	20	11
369	EC.arterial.homeostatic	0.23	Nonsignificant	0.99	0.52	Other	24	3
370	EPI.renal_distal_tubule.ciliated_remodelling	0.23	Nonsignificant	—	0.67	Other	0	0
371	FIB.suburothelial.inflammatory_prostanoid	0.23	Nonsignificant	—	0.00	Other	0	0
372	EPI.gastric_foveolar.baseline	0.23	Nonsignificant	—	0.00	Other	0	0
373	NK.cytokine_tissue_resident	0.22	Nonsignificant	0.71	1.23	Other	74	82
374	T.CD4_Th17.baseline	0.22	Nonsignificant	0.86	0.72	Other	51	5
375	T.CD4_naive.survival	0.22	Nonsignificant	0.94	0.88	Other	12	17
376	T.CD4_Tcm.retro_ZNF117	0.22	Nonsignificant	1.00	0.64	Other	5	9
377	T.CD4_naive.resist_bystander	0.22	Nonsignificant	0.94	0.83	Other	40	25
378	EC.arterial.ion_pump	0.22	Nonsignificant	0.99	0.49	Other	3	2
379	T.CD4_naive.proteostasis_mitoprot	0.22	Nonsignificant	0.94	0.74	Other	15	37
380	THYMO.DP_early_stress	0.21	Nonsignificant	—	0.00	Other	0	0
381	FIB.interstitial.lipid_matrix	0.21	Nonsignificant	1.00	0.07	Other	258	191
382	T.CD4_transitional.primed_helper_effector	0.21	Nonsignificant	0.98	0.80	Other	19	43
383	MAC.kupffer.monocyte_like	0.21	Nonsignificant	—	0.00	Other	0	0
384	SMC.activated	0.21	Nonsignificant	0.02	1.47	Other	2	5
385	CM.contractile_oxphos	0.21	Nonsignificant	1.00	0.02	Other	6	19
386	GRANU.MAST.activated_repair	0.20	Nonsignificant	—	0.00	Other	0	1
387	IPSC.mesenchymal_primed	0.20	Nonsignificant	1.00	0.76	Other	0	0
388	T.CD4_Tcm.RNA_control	0.20	Nonsignificant	1.00	0.43	Other	96	4
389	MONO.CD14.inflammatory	0.20	Nonsignificant	1.00	1.06	Other	92	134
390	T.CD4_Tem.long_term_memory	0.20	Nonsignificant	0.80	0.86	Other	314	587
391	T.CD8_Trm.dendritic_recruiter	0.19	Nonsignificant	1.00	0.78	Other	47	85
392	T.CD4_Th17.cytotoxic	0.19	Nonsignificant	0.86	0.79	Other	332	123
393	EC.capillary.angiogenic_tip	0.19	Nonsignificant	0.99	0.45	Other	186	218
394	EC.venous.quiescent_homeostatic	0.19	Nonsignificant	0.47	1.17	Other	456	360
395	EPI.lung_club_secretory.canonical_surfactant	0.19	Nonsignificant	—	0.00	Other	74	104
396	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.18	Nonsignificant	—	0.97	Other	0	0
397	T.CD8_Tcm.helper_like	0.18	Nonsignificant	0.49	1.17	Other	81	159
398	FIB.lung_alveolar.stress_interacting	0.18	Nonsignificant	—	0.00	Other	0	0
399	FIB.skin_sheath.ECM_immune	0.18	Nonsignificant	—	0.35	Other	0	0
400	T.gamma_delta.early_effector	0.18	Nonsignificant	0.19	1.08	Other	89	0
401	OLG.regulatory	0.18	Nonsignificant	1.00	0.09	Other	353	73
402	T.CD4_Tfh.effector_migratory	0.18	Nonsignificant	0.97	0.68	Other	122	57
403	T.CD4_naive.survival_mitoprot	0.17	Nonsignificant	0.94	0.76	Other	13	7
404	MONO.CD14.repair_M2_like	0.17	Nonsignificant	1.00	0.51	Other	550	1,495
405	T.CD4_transitional.primed_cytotoxic	0.17	Nonsignificant	0.98	0.56	Other	28	30
406	T.CD4_naive.purinergic	0.16	Nonsignificant	0.94	0.66	Other	49	1
407	ASPC.proliferative	0.16	Nonsignificant	1.00	0.09	Other	33	85
408	EPI.thymic_medullary.proliferative_APC	0.16	Nonsignificant	—	0.99	Other	0	0
409	T.CD8_naive.lipid_synthesis	0.15	Nonsignificant	0.56	1.30	Other	6	4
410	IPSC.proliferative	0.15	Nonsignificant	1.00	0.68	Other	0	0
411	T.CD4_Tfh.suppression_exhaustion	0.15	Nonsignificant	0.97	0.77	Other	0	2
412	EPI.alveolar_type_2.injury_primed	0.15	Nonsignificant	1.00	0.09	Other	434	245
413	EPI.tracheal_submucosal_gland.acinar_serous	0.14	Nonsignificant	—	0.00	Other	0	0
414	T.CD8_transitional.early	0.14	Nonsignificant	0.44	1.06	Other	327	55
415	T.CD8_Trm.homeostatic	0.14	Nonsignificant	1.00	0.79	Other	42	5
416	HPC.GMP_inflammatory	0.14	Nonsignificant	0.39	1.15	Other	20	10
417	T.CD4_Tem.cytotoxic_effector	0.13	Nonsignificant	0.80	0.95	Other	225	398
418	NK.cytokine_tissue_activation	0.13	Nonsignificant	0.71	1.20	Other	267	450
419	T.CD4_Tcm.tissue_homing	0.12	Nonsignificant	1.00	0.20	Other	78	46
420	DC.cDC2.pro_inflammatory	0.12	Nonsignificant	0.99	0.48	Other	3	5
421	T.CD8_naive.cytokine_dampened	0.12	Nonsignificant	0.56	1.18	Other	71	4
422	EPI.pancreatic_islet.beta	0.12	Nonsignificant	7.70e-03	1.25	Other	42	57
423	T.CD4_Tfh.canonical_GC_helper	0.12	Nonsignificant	0.97	0.51	Other	1	2
424	EPI.thymic_medullary.canonical_alarmin	0.12	Nonsignificant	0.28	1.40	Other	8	17
425	T.CD4_Trm.central_like	0.12	Nonsignificant	1.00	0.57	Other	38	31
426	SMC.metabolic	0.11	Nonsignificant	0.99	0.92	Other	14	40
427	MAC.kupffer.stress	0.11	Nonsignificant	0.74	0.90	Other	9	3
428	T.gamma_delta.cytotoxic_effector	0.11	Nonsignificant	0.46	1.04	Other	349	109
429	T.CD4_Trm.metal_stress	0.11	Nonsignificant	1.00	0.56	Other	34	58
430	FIB.skin_neurosecretory.baseline	0.11	Nonsignificant	—	0.00	Other	0	0
431	EPI.ileal_goblet.immature	0.11	Nonsignificant	—	0.43	Other	0	0
432	T.MAIT.MAPK_brake	0.11	Nonsignificant	0.86	1.15	Other	44	66
433	EPI.ileal_enterocyte_crypt.villus_transition	0.11	Nonsignificant	—	0.00	Other	7	10
434	T.MAIT.early_activation	0.10	Nonsignificant	0.86	1.21	Other	57	4
435	PERI.inflammatory	0.10	Nonsignificant	0.12	1.41	Other	40	77
436	EPI.colonic_enteroendocrine.Lcell_peptide	0.10	Nonsignificant	—	0.00	Other	0	0
437	T.CD8_naive.effector_transition	0.10	Nonsignificant	0.65	1.06	Other	35	62
438	T.CD8_naive.nfkb_related	0.10	Nonsignificant	0.56	1.22	Other	1	0
439	T.CD4_Trm.helper_like	0.10	Nonsignificant	1.00	0.77	Other	84	147
440	EC.arterial.angiogenic_tip	0.09	Nonsignificant	—	0.00	Other	30	37
441	T.CD8_naive.baseline	0.09	Nonsignificant	0.65	1.05	Other	142	2
442	EC.venous.baseline	0.09	Nonsignificant	1.00	0.92	Other	346	807
443	FIB.hepatic_stellate_cell.inflammatory	0.09	Nonsignificant	—	0.32	Other	0	0
444	T.MAIT.stress	0.09	Nonsignificant	—	0.00	Other	0	0
445	EPI.ileal_enterocyte_absorptive.villus_tip	0.09	Nonsignificant	1.61e-04	1.63	Other	4	3
446	MAC.resident_iron.stress_tolerogenic	0.09	Nonsignificant	—	1.16	Other	0	0
447	FIB.skin_sheath.stress_chaperone	0.09	Nonsignificant	—	0.00	Other	0	0
448	T.CD8_transitional.effector_primed	0.09	Nonsignificant	0.44	1.05	Other	435	151
449	FIB.hepatic_stellate_cell.fibrogenic	0.09	Nonsignificant	—	0.00	Other	0	0
450	PERI.baseline	0.09	Nonsignificant	0.70	1.10	Other	39	66
451	EC.venous.cardiac_structural	0.09	Nonsignificant	1.00	0.92	Other	102	229
452	PERI.cardiac_skeletal	0.08	Nonsignificant	0.77	0.98	Other	313	630
453	MAC.resident_iron.heme_catabolism	0.08	Nonsignificant	0.14	1.25	Other	30	51
454	EPI.endocervical_secretory.squamous_barrier	0.08	Nonsignificant	—	0.00	Other	0	0
455	CHOND.activated_fibro_like	0.08	Nonsignificant	0.99	0.95	Other	531	188
456	T.CD8_Tcm.gut_homing	0.08	Nonsignificant	1.00	0.83	Other	380	112
457	EPI.renal_immature_ureteric_bud.defense_secretory	0.08	Nonsignificant	0.12	1.31	Other	45	76
458	T.CD8_naive.vesicle_secretory	0.08	Nonsignificant	0.82	0.87	Other	42	0
459	T.CD8_transitional.Trm_primed	0.08	Nonsignificant	0.44	1.08	Other	108	15
460	SMC.contractile	0.08	Nonsignificant	0.99	0.46	Other	80	588
461	FIB.skin_papillary.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
462	T.CD8_naive.splicing_enriched	0.08	Nonsignificant	0.76	0.96	Other	120	16
463	B.age_associated.naive_transitional	0.08	Nonsignificant	—	1.03	Other	0	0
464	T.CD4_cytotoxic.precursor	0.07	Nonsignificant	0.49	1.20	Other	156	67
465	T.CD8_Tcm.effector_bias	0.07	Nonsignificant	1.00	0.59	Other	199	329
466	T.CD8_Trm.muscosal_Tc17	0.07	Nonsignificant	1.00	0.79	Other	19	38
467	EPI.salivary_duct_ion_transport.baseline	0.07	Nonsignificant	—	—	Other	0	0
468	T.CD8_Trm.cytotoxic	0.07	Nonsignificant	1.00	0.47	Other	165	85
469	FIB.skin_sheath.neuro_vascular_interface	0.06	Nonsignificant	—	6.94e-17	Other	0	0
470	EPI.pancreatic_ductal_bicarbonate.stress	0.06	Nonsignificant	—	0.00	Other	12	33
471	T.CD4_Th2.precursor	0.06	Nonsignificant	—	0.48	Other	0	0
472	T.MAIT.migratory	0.06	Nonsignificant	0.87	1.02	Other	10	1
473	T.CD4_cytotoxic.NK_adapted	0.06	Nonsignificant	0.55	1.06	Other	82	33
474	HPC.LMPP	0.06	Nonsignificant	0.90	0.84	Other	65	31
475	ASPC.stem_like_progenitor	0.06	Nonsignificant	1.00	0.89	Other	300	842
476	DC.cDC2.proliferative	0.06	Nonsignificant	—	0.00	Other	39	71
477	HPC.GMP_granulocytic	0.06	Nonsignificant	—	0.00	Other	3	3
478	PERI.angiocrine	0.06	Nonsignificant	0.98	0.54	Other	93	102
479	T.MAIT.cytotoxic	0.06	Nonsignificant	0.87	0.90	Other	52	15
480	FIB.transitioning.ISG_primed_interface	0.06	Nonsignificant	—	0.00	Other	17	80
481	T.CD8_Tem.signaling_turnover	0.05	Nonsignificant	0.06	1.25	Other	425	683
482	T.CD8_naive.mito_proteostasis	0.05	Nonsignificant	0.70	1.03	Other	428	100
483	T.CD8_naive.innate_like	0.05	Nonsignificant	0.91	0.64	Other	10	1
484	ASTRO.stress_acute	0.05	Nonsignificant	1.00	0.48	Other	60	56
485	T.CD4_naive.activated_stress	0.05	Nonsignificant	0.94	0.51	Other	339	429
486	FIB.hepatic_stellate_cell.contractile	0.05	Nonsignificant	—	0.00	Other	0	0
487	PC.IgG_systemic.stress	0.05	Nonsignificant	—	0.00	Other	1	5
488	T.CD4_cytotoxic.baseline	0.04	Nonsignificant	0.55	1.10	Other	0	0
489	EPI.pancreatic_ductal_progenitor.ADM_like	0.04	Nonsignificant	—	0.83	Other	0	0
490	EC.heart_remodeling.perivascular	0.04	Nonsignificant	0.56	1.17	Other	124	408
491	MAC.microglia_like.patrolling_adhesive	0.04	Nonsignificant	—	0.00	Other	0	0
492	T.CD4_cytotoxic.activated	0.04	Nonsignificant	0.49	1.16	Other	3	1
493	EC.heart_remodeling.remodeling_secretory	0.04	Nonsignificant	0.56	1.09	Other	605	1,341
494	HPC.MPP_IEG	0.04	Nonsignificant	0.90	0.67	Other	45	46
495	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.03	Nonsignificant	—	0.46	Other	0	0
496	EPI.ileal_bile_transport.detox_transcytosis	0.03	Nonsignificant	—	0.93	Other	0	1
497	EPI.thymic_medullary.stress_APC	0.03	Nonsignificant	0.92	0.35	Other	2	4
498	T.MAIT.quiescent	0.03	Nonsignificant	0.87	0.76	Other	100	5
499	CHOND.remodeling	0.03	Nonsignificant	—	0.00	Other	5	0
500	EPI.thymic_medullary.hormone_xeno_barrier	0.03	Nonsignificant	—	0.00	Other	0	8
501	T.MAIT.vesicle	0.03	Nonsignificant	0.87	0.69	Other	37	65
502	EC.heart_remodeling.angiocrine	0.03	Nonsignificant	0.79	0.94	Other	182	525
503	B.age_associated.migratory	0.03	Nonsignificant	0.38	1.16	Other	2	2
504	T.CD8_Tem.early_helper_like	0.03	Nonsignificant	0.27	1.13	Other	445	755
505	EPI.renal_distal_tubule.immune_modulatory	0.03	Nonsignificant	—	0.00	Other	0	0
506	NK.immature_bridge	0.03	Nonsignificant	1.00	0.99	Other	117	122
507	HEP.pericentral_lipoprotein.ApoB_coagulation	0.02	Nonsignificant	—	0.67	Other	0	0
508	IPSC.midbrain_primed	0.02	Nonsignificant	1.00	0.51	Other	0	0
509	MG.phagocytic_APC	0.02	Nonsignificant	0.86	0.98	Other	25	8
510	EPI.renal_intercalated_cell_type_B.baseline	0.02	Nonsignificant	—	0.00	Other	3	1
511	MG.baseline	0.02	Nonsignificant	0.86	1.04	Other	16	5
512	EPI.renal_immature_ureteric_bud.osmoprotective	0.02	Nonsignificant	0.93	0.67	Other	126	44
513	MAC.resident_iron.redox_metabolic	0.02	Nonsignificant	0.76	1.04	Other	4	4
514	IPSC.mesodermal_primed	0.02	Nonsignificant	1.00	0.71	Other	0	0
515	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.02	Nonsignificant	0.60	1.22	Other	14	32
516	EC.heart_remodeling.capillary_metabolic	0.02	Nonsignificant	0.56	1.35	Other	54	414
517	T.gamma_delta.central_memory	0.02	Nonsignificant	0.98	0.83	Other	460	919
518	ASTRO.A1_reactive	0.02	Nonsignificant	1.00	0.29	Other	433	394
519	IPSC.neural_primed	0.02	Nonsignificant	1.00	0.54	Other	0	0
520	EPI.alveolar_type_1.baseline	0.02	Nonsignificant	0.12	1.71	Other	8	0
521	EPI.salivary_mucous_acinar.baseline	0.02	Nonsignificant	—	—	Other	394	683
522	EC.venous.activated	0.02	Nonsignificant	1.00	0.56	Other	247	752
523	EPI.renal_intercalated_cell_type_A.acid_secretion	0.02	Nonsignificant	0.97	0.45	Other	12	6
524	HPC.CLP_B_primed	0.02	Nonsignificant	—	0.10	Other	0	0
525	MAC.kupffer.fibrogenic	0.02	Nonsignificant	—	0.00	Other	0	0
526	MAC.resident_repair.antigen_presenting	0.02	Nonsignificant	0.58	1.08	Other	244	113
527	EC.liver_sinusoidal.prostanoid	0.02	Nonsignificant	—	1.24	Other	11	64
528	EPI.ileal_bile_transport.absorptive_xenobiotic	0.02	Nonsignificant	1.00	0.00	Other	11	12
529	T.CD8_Tem.baseline	0.02	Nonsignificant	0.94	1.02	Other	458	356
530	MAC.proliferating.stress	0.02	Nonsignificant	—	0.18	Other	87	136
531	EPI.pancreatic_ductal_perivascular.baseline	0.01	Nonsignificant	0.14	1.45	Other	1	5
532	EC.lymphatic.tip_migratory	0.01	Nonsignificant	0.21	1.40	Other	23	37
533	EPI.pancreatic_ductal_progenitor.baseline	0.01	Nonsignificant	0.23	1.25	Other	179	702
534	EC.heart_remodeling.activated_acute	0.01	Nonsignificant	0.56	1.19	Other	102	186
535	T.CD8_transitional.APC_like	0.01	Nonsignificant	1.00	0.52	Other	205	62
536	T.CD8_Tcm.NK_like	0.01	Nonsignificant	1.00	0.09	Other	334	581
537	EC.lymphatic.scavenger	0.01	Nonsignificant	0.71	1.03	Other	203	257
538	NK.adaptive_adipose_stress	0.01	Nonsignificant	1.00	0.98	Other	374	39
539	T.CD8_Tem.stress_adapted	0.01	Nonsignificant	0.99	0.96	Other	607	520
540	EC.lymphatic.baseline	0.01	Nonsignificant	0.71	1.01	Other	38	72
541	NK.adaptive_axis_baseline	0.01	Nonsignificant	0.97	1.06	Other	1,008	153
542	EPI.ileal_enterocyte_crypt.secretory_precursor	0.01	Nonsignificant	—	0.00	Other	0	0
543	CHOND.articular_collagen	0.01	Nonsignificant	1.00	0.08	Other	551	266
544	MAC.resident_cardiac.antigen_presenting	0.01	Nonsignificant	0.35	1.26	Other	52	27
545	EPI.pancreatic_ductal_bicarbonate.activated	0.01	Nonsignificant	0.60	1.22	Other	10	7
546	EPI.cervical_suprabasal.inflammatory_repair	0.01	Nonsignificant	—	0.00	Other	0	0
547	DC.cDC2.lipid_metabolic	0.01	Nonsignificant	—	0.00	Other	0	0
548	EC.liver_sinusoidal.hypoxia_metabolic	0.01	Nonsignificant	0.11	1.35	Other	183	107
549	HEP.pericentral_lipoprotein.UPR_redox	0.01	Nonsignificant	—	0.00	Other	0	0
550	T.CD4_cytotoxic.terminal_effector	9.77e-03	Nonsignificant	0.90	0.85	Other	286	21
551	EPI.lung_club_secretory.inflammatory	9.53e-03	Nonsignificant	—	0.00	Other	0	0
552	FIB.skin_tenogenic.baseline	9.29e-03	Nonsignificant	—	0.00	Other	0	2
553	EC.liver_sinusoidal.remodeling_lipotoxicity	9.24e-03	Nonsignificant	—	0.57	Other	90	58
554	B.age_associated.activated	9.23e-03	Nonsignificant	—	0.00	Other	18	22
555	EPI.alveolar_type_1.activated	9.18e-03	Nonsignificant	—	0.00	Other	0	0
556	EC.heart_remodeling.translation_boost	8.62e-03	Nonsignificant	—	0.00	Other	0	0
557	HEP.periportal_metabolic.acute_phase_barrier	8.36e-03	Nonsignificant	0.29	1.11	Other	533	138
558	ASTRO.neuromodulatory	8.34e-03	Nonsignificant	1.00	0.27	Other	34	172
559	EPI.pancreatic_ductal_bicarbonate.baseline	7.44e-03	Nonsignificant	0.60	1.11	Other	11	42
560	MAC.LAM.inflammatory_APC	7.35e-03	Nonsignificant	0.67	1.05	Other	872	165
561	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	7.26e-03	Nonsignificant	—	0.00	Other	0	0
562	EC.heart_remodeling.remodeling_stalk	7.18e-03	Nonsignificant	0.99	0.37	Other	33	111
563	MG.expanding	6.49e-03	Nonsignificant	0.91	0.55	Other	2	1
564	MAC.MDM.complement_resolving	6.22e-03	Nonsignificant	1.00	0.16	Other	440	860
565	EPI.pancreatic_ductal_progenitor.ciliated_transport	6.20e-03	Nonsignificant	—	0.00	Other	105	368
566	EPI.renal_distal_tubule.repair	6.09e-03	Nonsignificant	—	0.00	Other	34	102
567	EPI.renal_distal_tubule.stress	5.83e-03	Nonsignificant	—	0.00	Other	0	0
568	EPI.colonocyte.distal_absorptive	5.80e-03	Nonsignificant	—	0.00	Other	0	0
569	NK.cytokine_axis_baseline	5.47e-03	Nonsignificant	1.00	0.83	Other	1,172	116
570	EPI.pancreatic_ductal_perivascular.protective_antioxidant	5.41e-03	Nonsignificant	—	0.00	Other	11	69
571	MAC.kupffer.metabolic	5.39e-03	Nonsignificant	—	0.00	Other	25	36
572	EPI.hepatic_ductular_cholangiocyte.polarity	5.34e-03	Nonsignificant	—	1.32	Other	0	0
573	EPI.salivary_serous_acinar.seromucous_like	5.29e-03	Nonsignificant	—	0.00	Other	0	0
574	EPI.ileal_enterocyte_absorptive.brush_border	4.99e-03	Nonsignificant	1.00	0.00	Other	580	1,717
575	EC.lymphatic.activated	4.53e-03	Nonsignificant	0.76	0.83	Other	47	73
576	EPI.pancreatic_acinar.stress	4.42e-03	Nonsignificant	0.23	1.50	Other	28	28
577	NK.adaptive_immature_precursor	4.33e-03	Nonsignificant	1.00	0.88	Other	358	111
578	MAC.resident_repair.chemokine_angiocrine	4.04e-03	Nonsignificant	0.84	1.00	Other	87	138
579	MAC.MDM.LAM_like	4.00e-03	Nonsignificant	1.00	0.33	Other	12	14
580	T.CD4_Th2.tissue_adapted	3.83e-03	Nonsignificant	—	0.00	Other	0	0
581	MAC.kupffer.inflammatory	3.73e-03	Nonsignificant	—	0.00	Other	7	4
582	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	3.71e-03	Nonsignificant	—	0.73	Other	0	0
583	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	3.67e-03	Nonsignificant	—	0.00	Other	0	0
584	MAC.resident_iron.APC_iron_sensing	3.61e-03	Nonsignificant	0.96	0.77	Other	211	114
585	EPI.ileal_goblet.inflammatory_mucin	3.48e-03	Nonsignificant	0.70	1.21	Other	6	9
586	IPSC.neuroendocrine_primed	3.44e-03	Nonsignificant	—	0.00	Other	0	0
587	NK.cytokine_repair_primed	3.16e-03	Nonsignificant	1.00	0.87	Other	266	11
588	EC.lymphatic.valve	3.14e-03	Nonsignificant	—	0.00	Other	0	0
589	NK.adaptive_classII_inhibitory	3.12e-03	Nonsignificant	1.00	1.06	Other	880	154
590	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.94e-03	Nonsignificant	—	0.73	Other	0	0
591	NK.cytokine_biosynthetic_primed	2.89e-03	Nonsignificant	1.00	0.87	Other	360	21
592	MAC.LAM.anti_inflammatory	2.77e-03	Nonsignificant	0.67	1.04	Other	86	132
593	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.74e-03	Nonsignificant	—	0.62	Other	0	0
594	EC.liver_sinusoidal.inflammatory	2.70e-03	Nonsignificant	—	0.00	Other	223	154
595	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	2.63e-03	Nonsignificant	—	0.00	Other	49	237
596	GRNLSA.lipid_hypoxia	2.58e-03	Nonsignificant	0.30	1.20	Other	28	0
597	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.47e-03	Nonsignificant	—	0.85	Other	0	0
598	NK.adaptive_biosynthetic_primed	2.45e-03	Nonsignificant	1.00	0.91	Other	244	405
599	EPI.cervical_suprabasal.secretory_vesicle	2.40e-03	Nonsignificant	—	0.00	Other	0	0
600	T.CD8_Tem.TEMRA	2.38e-03	Nonsignificant	0.99	0.73	Other	920	1,088
601	IPSC.stress	2.36e-03	Nonsignificant	1.00	0.39	Other	0	0
602	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.28e-03	Nonsignificant	—	0.00	Other	0	0
603	EC.venous.remodeling_stalk	2.26e-03	Nonsignificant	1.00	0.26	Other	559	566
604	DC.mig.baseline	2.10e-03	Nonsignificant	—	0.00	Other	1	0
605	MAC.resident_repair.lipid_phagocytic	2.07e-03	Nonsignificant	0.58	1.20	Other	228	604
606	EPI.pancreatic_acinar.inflammatory_regenerative	1.94e-03	Nonsignificant	0.23	1.48	Other	25	113
607	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.92e-03	Nonsignificant	—	0.42	Other	0	0
608	T.CD8_Tem.motility_primed	1.69e-03	Nonsignificant	0.99	0.74	Other	269	4
609	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	1.54e-03	Nonsignificant	0.98	0.40	Other	219	533
610	GRNLSA.cholesterol_mevalonate	1.54e-03	Nonsignificant	0.30	1.25	Other	9	4
611	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.53e-03	Nonsignificant	0.98	0.42	Other	40	191
612	EPI.ileal_goblet.stress_metallothionein	1.39e-03	Nonsignificant	—	0.03	Other	4	11
613	NK.cytokine_vascular_patrolling	1.33e-03	Nonsignificant	1.00	0.64	Other	863	94
614	EC.liver_sinusoidal.secretory_lipoprotein	1.32e-03	Nonsignificant	0.99	0.30	Other	120	70
615	MAC.LAM.lipid_opsonization	1.19e-03	Nonsignificant	0.61	1.17	Other	45	14
616	EPI.colonic_enteroendocrine.progenitor	1.18e-03	Nonsignificant	—	0.00	Other	0	0
617	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.17e-03	Nonsignificant	0.93	0.27	Other	449	1,034
618	EPI.ileal_goblet.baseline	1.11e-03	Nonsignificant	0.92	0.40	Other	16	2
619	NK.adaptive_HLAE_tuned	1.02e-03	Nonsignificant	1.00	0.71	Other	1,124	189
620	CM.inflammatory	1.00e-03	Nonsignificant	—	0.00	Other	0	0
621	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.00e-03	Nonsignificant	—	0.00	Other	0	0
622	GRNLSA.proliferative_migratory	9.89e-04	Nonsignificant	0.67	0.99	Other	248	292
623	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	9.57e-04	Nonsignificant	—	0.00	Other	5	3
624	HEP.canalicular_transport.secretory_ERAD_UPR	9.06e-04	Nonsignificant	0.59	1.13	Other	232	28
625	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	9.01e-04	Nonsignificant	—	0.35	Other	6	9
626	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	8.33e-04	Nonsignificant	—	0.00	Other	0	0
627	NK.cytokine_quiescent	7.28e-04	Nonsignificant	1.00	0.59	Other	623	1,062
628	MAC.LAM.perivascular_angiocrine	6.87e-04	Nonsignificant	—	0.04	Other	53	138
629	EPI.pancreatic_acinar.adhesion_remodeling	6.29e-04	Nonsignificant	0.69	0.89	Other	210	784
630	EPI.pancreatic_acinar.metabolic_onecarbon	5.40e-04	Nonsignificant	0.69	0.86	Other	287	328
631	MAC.alveolar.stress_metabolic	4.96e-04	Nonsignificant	0.58	1.19	Other	116	148
632	HEP.periportal_metabolic.stress_checkpoint	4.34e-04	Nonsignificant	0.92	1.03	Other	234	786
633	GRNLSA.chemokine_mechanosensory	4.20e-04	Nonsignificant	0.67	0.95	Other	1	0
634	GRNLSA.EMT_insulin_signaling	3.82e-04	Nonsignificant	0.67	1.10	Other	47	84
635	EPI.pancreatic_acinar.baseline	3.77e-04	Nonsignificant	0.69	0.87	Other	274	163
636	EPI.pancreatic_acinar.quiet_dedifferentiation	3.57e-04	Nonsignificant	0.69	0.94	Other	142	171
637	EC.liver_sinusoidal.stress	3.49e-04	Nonsignificant	—	0.00	Other	413	158
638	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.45e-04	Nonsignificant	—	0.00	Other	0	0
639	HEP.periportal_metabolic.xenobiotic_detox	3.37e-04	Nonsignificant	0.79	1.03	Other	1,440	139
640	EPI.thymic_cortical.secretory_remodeling	3.34e-04	Nonsignificant	—	1.00	Other	4	1
641	EPI.extrahepatic_cholangiocyte.barrier_interface	1.75e-04	Nonsignificant	—	0.00	Other	0	0
642	NK.adaptive_terminal_cytotoxic	1.68e-04	Nonsignificant	1.00	0.32	Other	485	802
643	EPI.hepatic_ductular_cholangiocyte.stress	1.52e-04	Nonsignificant	—	0.00	Other	0	0
644	MAC.LAM.lipid_phagocytosis	1.51e-04	Nonsignificant	0.98	0.87	Other	369	328
645	HEP.acute_phase.stress_secretory	1.39e-04	Nonsignificant	0.36	1.35	Other	26	3
646	MAC.proliferating.DNA_replication	1.16e-04	Nonsignificant	0.89	0.83	Other	3	6
647	EPI.pancreatic_islet.alpha	9.97e-05	Nonsignificant	—	0.00	Other	152	330
648	MAC.resident_repair.stress_iron	9.39e-05	Nonsignificant	0.84	1.01	Other	48	97
649	GRNLSA.secretory_remodeling	9.25e-05	Nonsignificant	0.67	0.94	Other	90	25
650	MAC.alveolar.biosynthetic_sterol_heme	9.13e-05	Nonsignificant	0.62	1.06	Other	347	40
651	HEP.periportal_metabolic.urea_onecarbon_secretory	7.35e-05	Nonsignificant	0.92	1.00	Other	1,332	3,053
652	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	5.54e-05	Nonsignificant	—	0.00	Other	0	0
653	MAC.alveolar.capillary_interacting	5.38e-05	Nonsignificant	0.62	1.14	Other	113	181
654	MAC.resident_cardiac.inflammatory_reparative	4.83e-05	Nonsignificant	0.80	0.99	Other	31	96
655	HEP.periportal_metabolic.apolipoprotein_secretory	4.74e-05	Nonsignificant	0.79	1.16	Other	43	110
656	EPI.pancreatic_islet.delta	4.51e-05	Nonsignificant	—	0.00	Other	0	0
657	GRNLSA.stress_metabolic	4.07e-05	Nonsignificant	—	0.00	Other	1	2
658	GRNLSA.angiocrine_mechanosensory	3.68e-05	Nonsignificant	—	0.15	Other	0	0
659	MAC.resident_iron.heme_recycling	3.33e-05	Nonsignificant	—	0.00	Other	30	37
660	HEP.acute_phase.complement_antiviral	2.89e-05	Nonsignificant	0.51	1.17	Other	377	751
661	EPI.bile_duct_cholangiocyte.inflammatory_APC	2.71e-05	Nonsignificant	—	0.07	Other	2	0
662	MAC.resident_cardiac.phagocytic_homeostasis	2.12e-05	Nonsignificant	1.00	0.55	Other	564	1,221
663	HEP.canalicular_transport.sterol_lipid_biosynthesis	2.06e-05	Nonsignificant	—	0.47	Other	10	20
664	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.80e-05	Nonsignificant	—	0.00	Other	0	0
665	MAC.LAM.antimicrobial	1.74e-05	Nonsignificant	0.98	0.72	Other	389	93
666	HEP.acute_phase.proliferative	1.35e-05	Nonsignificant	—	1.03	Other	4	6
667	HEP.canalicular_transport.injury_stress	1.20e-05	Nonsignificant	0.97	0.97	Other	289	24
668	HEP.canalicular_transport.pericentral_like_hypoxia	1.06e-05	Nonsignificant	0.97	1.01	Other	326	8
669	MAC.alveolar.lipid_autophagy	8.96e-06	Nonsignificant	—	0.00	Other	35	44
670	HEP.periportal_metabolic.inflammatory_activated	8.65e-06	Nonsignificant	1.00	0.83	Other	712	1,610
671	MAC.alveolar.inflammatory	6.47e-06	Nonsignificant	0.88	0.78	Other	208	312
672	HEP.canalicular_transport.inflammatory	6.17e-06	Nonsignificant	0.97	0.88	Other	1,335	194
673	HEP.canalicular_transport.ductular_like_transition	5.35e-06	Nonsignificant	0.97	1.00	Other	400	87
674	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	3.65e-06	Nonsignificant	—	0.00	Other	0	0
675	MAC.resident_repair.ECM_stromal_crosstalk	3.59e-06	Nonsignificant	0.98	0.74	Other	95	158
676	GRNLSA.p53_damage	3.47e-06	Nonsignificant	—	0.00	Other	13	10
677	EPI.bile_duct_cholangiocyte.secretory_mucin	2.83e-06	Nonsignificant	—	0.00	Other	7	12
678	MAC.alveolar.scavenging_endocytic	1.83e-06	Nonsignificant	—	0.00	Other	140	283
679	ADIPO.inflammatory	1.67e-06	Nonsignificant	—	0.00	Other	0	0
680	HEP.acute_phase.inflammatory	1.18e-06	Nonsignificant	1.00	0.94	Other	382	649
681	HEP.acute_phase.complement_metabolic	5.27e-07	Nonsignificant	1.00	0.72	Other	1,423	3,464
682	HEP.acute_phase.baseline	5.15e-07	Nonsignificant	1.00	0.61	Other	946	19
683	HEP.periportal_metabolic.stress_chaperone	4.94e-07	Nonsignificant	—	0.26	Other	66	128
684	HEP.periportal_metabolic.canonical_urea_cycle	7.20e-08	Nonsignificant	1.00	0.29	Other	1,464	269
685	HEP.canalicular_transport.baseline	5.27e-08	Nonsignificant	0.97	0.77	Other	199	477
686	EPI.thymic_cortical.Notch_interface	1.31e-08	Nonsignificant	—	0.00	Other	82	137
687	EPI.thymic_cortical.baseline	9.70e-09	Nonsignificant	0.76	0.62	Other	185	386
688	HEP.acute_phase.hypoxia_lipid	8.91e-09	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

36 unique genes. Showing 1–36. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
C4orf36	01-High	0.54	8.48	G1	C1	—	—	—	18	47
ENSG00000304926	02-Medium	0.63	17.85	G1	C2	—	—	—	251	496
PNPLA3	02-Medium	0.58	13.83	G1	C2	GRANU.MAST.resting_granule (L2)	—	17 cells — complete matches	251	496
SAMM50	02-Medium	0.56	15.15	G1	C2	—	—	6 cells — complete matches	256	506
PNPLA5	02-Medium	0.49	12.78	G1	C2	—	—	—	251	496
C4orf36.2	02-Medium	0.47	10.22	G1	C2	—	—	—	63	504
PARVB	02-Medium	0.47	16.15	G2	C2	PLAT.adhesion (L2)	EPI.skin_appendage_keratinocyte.sebaceous_apocrine (Tier: specific)	25 cells — complete matches	35	46
ENSG00000284968	02-Medium	0.45	8.64	G1	C2	—	—	—	63	504
SLC10A6	02-Medium	0.42	7.41	G2	C2	—	EPI.skin_interfollicular_spinous (Tier: specific) EPI.skin_sebaceous_duct_luminal (Tier: specific) EPI.skin_keratinocyte_progenitor (Tier: relevant) EPI.skin_keratinocyte_progenitor.quiescent_stem_like (Tier: relevant) EPI.skin_sebaceous_duct_luminal.ECM_remodelling (Tier: relevant) EPI.skin_sebaceous_duct_luminal.immune_interface (Tier: relevant)	39 cells — complete matches	1	1
TM6SF2	02-Medium	0.41	1.66	G1	C2	—	—	25 cells — complete matches	55	149
ENSG00000267629	02-Medium	0.41	1.62	G1	C2	—	—	—	55	149
HAPLN4	02-Medium	0.41	1.56	G1	C2	—	—	9 cells — complete matches	30	97
ZNF682	02-Medium	0.40	3.95	G2	C2	—	—	18 cells — complete matches	0	0
ZNF506	02-Medium	0.39	2.84	G2	C2	—	—	4 cells — complete matches	1	2
LINC00663	02-Medium	0.39	2.57	G2	C2	—	—	20 cells — complete matches	0	0
ZNF56P.2	02-Medium	0.34	2.58	G2	C2	—	—	—	0	1
PBX4	02-Medium	0.33	2.00	G2	C2	—	—	95 cells — complete matches	51	106
HLA-C	02-Medium	0.32	1.26	G1	C2	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), NEU.EXC_CT.remodeling (L2), OPC.proliferative_immune_interact (L2)	—	76 cells — complete matches	738	1,070
USP8P1	02-Medium	0.31	1.86	G2	C2	—	—	—	0	0
ENSG00000259242	02-Medium	0.31	2.36	G2	C2	—	—	—	5	10
ENSG00000294647	02-Medium	0.29	0.90	G2	C2	—	—	—	99	437
LINC00229	02-Medium	0.28	6.40	G2	C2	—	—	—	1	0
SULT4A1	02-Medium	0.27	9.13	G2	C2	—	—	7 cells — complete matches	249	495
SHISAL1	02-Medium	0.27	8.64	G2	C2	—	—	—	1	1
ENSG00000279175	02-Medium	0.27	7.29	G2	C2	—	—	—	1	1
PARVG	02-Medium	0.26	7.21	G2	C2	—	—	42 cells — complete matches	2	1
ENSG00000309629	02-Medium	0.25	2.25	G2	C2	—	—	—	25	47
LPAR2	02-Medium	0.25	2.16	G2	C2	—	—	74 cells — complete matches	15	30
ENSG00000280434	02-Medium	0.25	7.08	G2	C2	—	—	—	1	1
GMIP	02-Medium	0.24	2.48	G2	C2	—	SKM.type_2_fast (Tier: specific)	32 cells — complete matches	30	114
GATAD2A	02-Medium	0.23	0.91	G2	C2	—	—	4 cells — complete matches	106	465
CILP2	02-Medium	0.22	1.25	G2	C2	—	—	15 cells — complete matches	50	108
MAU2	02-Medium	0.21	1.56	G2	C2	—	—	21 cells — complete matches	61	221
PRR5	02-Medium	0.20	4.07	G2	C2	T.CD4_Trm.helper_like (L2)	—	47 cells — complete matches	2	1
PTPN13	02-Medium	0.16	4.66	G2	C2	—	—	51 cells — complete matches	11	125
MAPK10	02-Medium	0.14	3.13	G2	C2	EPI.lung_multiciliated.mature_motile_cilia (L2)	SCHWN.axon_contact_cardiac (Tier: specific)	30 cells — complete matches	11	38

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.