Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000052 · All tissues

Alcohol use disorder, ICD-based: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Alcohol use disorder

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte	45.25	Significant	3.30e-49	1.26	Specific	385	1,507
2	induced_pluripotent_stem_cell	13.74	Significant	1.29e-22	1.13	Relevant	0	0
3	neuron	12.46	Significant	0.15	1.05	Relevant	330	1,328
4	haematopoietic_progenitor_cell	10.70	Significant	1.00	1.01	Relevant	262	502
5	platelet	7.26	Significant	—	1.05	Other	85	104
6	astrocyte	7.17	Significant	0.52	1.04	Relevant	256	1,203
7	oligodendrocyte_precursor_cell	7.01	Significant	1.00	1.03	Relevant	461	1,454
8	dendritic_cell	5.43	Nominal	1.00	0.99	Other	496	724
9	schwann_cell	5.35	Nominal	1.00	0.96	Other	10	57
10	melanocyte	4.78	Nominal	1.00	0.98	Other	97	309
11	epithelial_cell	2.92	Nonsignificant	1.00	0.97	Other	24	47
12	monocyte	2.81	Nonsignificant	1.00	0.97	Other	2,176	3,871
13	microglia	1.34	Nonsignificant	1.00	0.89	Other	61	129
14	hepatocyte	0.99	Nonsignificant	1.00	0.84	Other	1,515	3,822
15	skeletal_muscle_cell	0.91	Nonsignificant	1.00	0.89	Other	944	2,600
16	granulosa_cell	0.81	Nonsignificant	1.00	0.82	Other	293	670
17	macrophage	0.58	Nonsignificant	1.00	0.83	Other	813	1,732
18	granulocyte	0.32	Nonsignificant	1.00	0.73	Other	5	6
19	thymocyte	0.19	Nonsignificant	1.00	0.82	Other	168	512
20	smooth_muscle_cell	0.19	Nonsignificant	1.00	0.69	Other	27	139
21	plasma_cell	0.17	Nonsignificant	1.00	0.68	Other	17	24
22	endothelial_cell	0.12	Nonsignificant	1.00	0.70	Other	373	974
23	cardiomyocyte	0.12	Nonsignificant	1.00	0.67	Other	533	2,045
24	B_cell	0.10	Nonsignificant	1.00	0.72	Other	356	694
25	fibroblast	0.03	Nonsignificant	1.00	0.56	Other	184	826
26	muscle_stem_cell	0.03	Nonsignificant	1.00	0.56	Other	7	27
27	T_cell	0.02	Nonsignificant	1.00	0.42	Other	470	959
28	innate_lymphoid_cell_2	0.02	Nonsignificant	1.00	0.64	Other	3	8
29	pericyte	0.02	Nonsignificant	1.00	0.52	Other	128	517
30	adipose_stem_and_progenitor_cell	0.01	Nonsignificant	1.00	0.53	Other	327	954
31	chondrocyte	5.04e-03	Nonsignificant	1.00	0.38	Other	548	1,069
32	natural_killer_cell	4.92e-03	Nonsignificant	1.00	0.52	Other	1,204	2,052
33	adipocyte	3.46e-03	Nonsignificant	1.00	0.36	Other	33	111
34	mesothelial_cell	2.95e-03	Nonsignificant	1.00	0.39	Other	6	36

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OLG.oligodendrocyte	45.25	Significant	—	—	Specific	384	1,397
2	EPI.intrahepatic_cholangiocyte_transport	38.90	Significant	—	2.50	Relevant	12	42
3	EPI.esophageal_suprabasal	28.25	Significant	2.82e-03	1.28	Specific	158	404
4	NEU.EXC_IT	16.25	Significant	1.26e-06	2.00	—	411	192
5	IPSC.induced_pluripotent_stem_cell	13.74	Significant	—	—	Relevant	0	0
6	NEU.EXC_NTNG1	13.68	Significant	—	0.27	—	0	0
7	NEU.EXC_CT	13.66	Significant	1.00	0.90	—	362	384
8	EPI.hepatic_ductular_cholangiocyte	13.38	Significant	1.00	1.12	Relevant	83	243
9	NEU.INH_PVALB	12.52	Significant	1.00	0.96	—	193	183
10	NEU.EXC_SYT2	12.16	Significant	—	0.17	—	40	77
11	EPI.skin_interfollicular_spinous	12.11	Significant	0.15	1.15	Relevant	260	563
12	EPI.tracheal_suprabasal	11.04	Significant	1.00	1.15	Relevant	29	56
13	HPC.haematopoietic_progenitor_cell	10.70	Significant	—	—	Relevant	211	370
14	EPI.skin_keratinocyte_proliferating	10.26	Significant	1.00	1.07	Relevant	47	76
15	EPI.pancreatic_ductal_bicarbonate	10.20	Significant	0.11	1.14	Relevant	131	548
16	EPI.esophageal_basal	10.12	Significant	1.00	1.07	Relevant	4	10
17	EPI.intrahepatic_cholangiocyte_defense	7.90	Significant	—	1.10	Relevant	8	13
18	DC.pDC	7.80	Significant	0.64	1.14	Relevant	496	1,028
19	EPI.tracheal_basal	7.72	Significant	1.00	1.08	Relevant	398	1,120
20	PLAT.platelet	7.26	Significant	—	0.00	Other	38	53
21	ASTRO.astrocyte	7.17	Significant	—	—	Relevant	228	1,111
22	OPC.oligodendrocyte_precursor_cell	7.01	Significant	—	—	Relevant	413	1,269
23	EPI.bile_duct_cholangiocyte	6.68	Significant	1.00	1.03	Relevant	37	60
24	EPI.ectocervical_granular	6.46	Significant	—	0.44	Other	11	23
25	EPI.colonic_tuft	5.38	Nominal	—	0.89	Other	7	24
26	SCHWN.schwann_cell	5.35	Nominal	—	—	Other	7	33
27	DC.cDC2	5.32	Nominal	0.94	0.93	Other	1,189	1,793
28	EPI.pancreatic_islet	4.91	Nominal	1.00	1.00	Other	52	132
29	MEL.melanocyte	4.78	Nominal	—	—	Other	79	242
30	EPI.cervical_suprabasal	4.51	Nominal	—	0.83	Other	14	50
31	EPI.endocervical_secretory	4.45	Nominal	—	0.90	Other	0	0
32	EPI.pancreatic_acinar	4.34	Nominal	1.00	1.03	Other	429	1,475
33	EPI.extrahepatic_cholangiocyte	3.99	Nominal	—	0.81	Other	37	71
34	EPI.skin_keratinocyte_basal	3.90	Nominal	—	0.68	Other	13	26
35	NEU.INH_VIP	3.74	Nominal	1.00	0.16	Other	241	366
36	MAC.MDM	3.62	Nominal	6.69e-05	1.21	Other	623	986
37	MONO.CD14	3.21	Nominal	1.57e-17	1.54	Other	2,294	4,139
38	DC.cDC1	2.80	Nonsignificant	0.94	0.62	Other	55	112
39	EPI.salivary_duct_excretory	2.49	Nonsignificant	1.00	0.91	Other	85	180
40	EPI.colonic_enteroendocrine	2.40	Nonsignificant	—	0.65	Other	1	1
41	HEP.periportal_metabolic	2.37	Nonsignificant	2.21e-26	1.39	Other	1,750	4,427
42	EPI.pancreatic_ductal_perivascular	1.87	Nonsignificant	1.00	0.93	Other	4	30
43	EC.lymphatic	1.85	Nonsignificant	2.07e-05	1.26	Other	630	998
44	EPI.skin_keratinocyte_progenitor	1.79	Nonsignificant	—	0.59	Other	0	3
45	EPI.pancreatic_ductal_mucinous	1.68	Nonsignificant	1.00	0.90	Other	219	430
46	SKM.type_1_slow	1.51	Nonsignificant	7.76e-37	2.83	Other	923	2,478
47	MG.microglia	1.34	Nonsignificant	—	—	Other	49	0
48	NEU.INH_LAMP5	1.27	Nonsignificant	1.00	0.00	Other	263	532
49	EPI.ileal_goblet	1.24	Nonsignificant	1.00	0.90	Other	181	432
50	DC.mig	1.08	Nonsignificant	—	0.00	Other	89	156
51	EPI.alveolar_type_1	1.05	Nonsignificant	1.00	0.85	Other	26	101
52	MAC.kupffer	0.92	Nonsignificant	1.00	1.03	Other	189	530
53	GRNLSA.granulosa_cell	0.81	Nonsignificant	—	—	Other	257	0
54	MONO.CD16	0.73	Nonsignificant	1.00	0.29	Other	1,304	1,835
55	EPI.skin_sebaceous_duct_luminal	0.68	Nonsignificant	1.00	0.70	Other	100	249
56	EPI.skin_follicular_keratinizing	0.56	Nonsignificant	1.00	0.77	Other	30	81
57	EPI.salivary_intercalated_defense	0.52	Nonsignificant	1.00	0.79	Other	81	161
58	SKM.type_2_fast	0.48	Nonsignificant	1.00	0.13	Other	972	2,639
59	GRANU.MAST	0.46	Nonsignificant	5.14e-03	1.87	Other	5	6
60	EPI.gastric_foveolar	0.44	Nonsignificant	—	0.30	Other	0	0
61	FIB.transitioning	0.44	Nonsignificant	0.24	1.29	Other	172	497
62	PC.IgG_systemic	0.42	Nonsignificant	0.04	1.25	Other	41	60
63	EPI.tracheal_submucosal_gland	0.36	Nonsignificant	—	0.18	Other	0	0
64	EPI.ileal_enterocyte_absorptive	0.36	Nonsignificant	1.00	0.72	Other	118	338
65	EPI.pancreatic_ductal_progenitor	0.34	Nonsignificant	1.00	0.68	Other	234	873
66	FIB.hepatic_stellate_cell	0.31	Nonsignificant	—	2.02	Other	64	252
67	B.age_associated	0.29	Nonsignificant	0.72	1.05	Other	207	350
68	MAC.resident_iron	0.28	Nonsignificant	1.00	0.95	Other	16	21
69	MAC.proliferating	0.28	Nonsignificant	1.00	1.01	Other	87	253
70	FIB.tracheal_subepithelial	0.27	Nonsignificant	—	1.72	Other	0	0
71	HEP.canalicular_transport	0.27	Nonsignificant	1.00	0.69	Other	1,290	3,434
72	EPI.alveolar_type_2	0.25	Nonsignificant	1.00	0.67	Other	813	1,853
73	EPI.ileal_bile_transport	0.24	Nonsignificant	1.00	0.67	Other	61	93
74	MAC.alveolar	0.24	Nonsignificant	1.00	0.83	Other	1,432	3,122
75	EPI.salivary_duct_ion_transport	0.21	Nonsignificant	1.00	0.62	Other	5	11
76	THYMO.thymocyte	0.19	Nonsignificant	—	—	Other	163	495
77	SMC.smooth_muscle_cell	0.19	Nonsignificant	—	—	Other	20	101
78	FIB.reticular	0.17	Nonsignificant	0.55	1.16	Other	19	87
79	EC.liver_sinusoidal	0.15	Nonsignificant	1.00	1.02	Other	1,083	1,925
80	EPI.renal_thick_ascending_limb	0.15	Nonsignificant	1.00	0.57	Other	453	1,153
81	HEP.pericentral_lipoprotein	0.14	Nonsignificant	—	0.00	Other	0	0
82	PC.IgA_muocsal	0.14	Nonsignificant	1.00	0.47	Other	18	31
83	B.naive	0.13	Nonsignificant	0.41	1.04	Other	307	595
84	CM.cardiomyocyte	0.12	Nonsignificant	—	—	Other	524	2,032
85	FIB.perivascular_interface	0.11	Nonsignificant	0.55	1.24	Other	0	0
86	EPI.ileal_enterocyte_crypt	0.09	Nonsignificant	1.00	0.56	Other	67	113
87	GRANU.neutrophil	0.08	Nonsignificant	1.00	0.00	Other	1,235	2,649
88	EC.arterial	0.08	Nonsignificant	1.00	0.98	Other	356	885
89	MAC.microglia_like	0.08	Nonsignificant	1.00	0.79	Other	124	179
90	FIB.barrier_purinergic	0.08	Nonsignificant	—	1.01	Other	1	3
91	EPI.salivary_serous_acinar	0.08	Nonsignificant	1.00	0.64	Other	233	531
92	EPI.renal_intercalated_cell_type_A	0.07	Nonsignificant	1.00	0.54	Other	67	142
93	B.memory	0.07	Nonsignificant	1.00	0.93	Other	442	882
94	T.CD4_Tfh	0.06	Nonsignificant	0.63	1.18	Other	47	45
95	HEP.acute_phase	0.06	Nonsignificant	1.00	0.18	Other	1,441	3,641
96	MAC.LAM	0.06	Nonsignificant	1.00	0.75	Other	914	2,064
97	MAC.resident_cardiac	0.06	Nonsignificant	1.00	0.67	Other	485	1,074
98	T.CD4_naive	0.05	Nonsignificant	0.59	1.07	Other	399	866
99	EC.venous	0.05	Nonsignificant	1.00	0.84	Other	516	1,387
100	EPI.skin_sweat_duct_keratinocyte	0.05	Nonsignificant	1.00	0.53	Other	146	301
101	EPI.renal_intercalated_cell_type_B	0.04	Nonsignificant	—	0.00	Other	6	7
102	FIB.skin_neurosecretory	0.04	Nonsignificant	—	1.19	Other	0	0
103	T.CD4_transitional	0.04	Nonsignificant	0.64	1.10	Other	48	110
104	FIB.lung_alveolar	0.04	Nonsignificant	—	1.07	Other	6	15
105	T.CD4_Th17	0.04	Nonsignificant	0.63	1.20	Other	421	794
106	EC.capillary	0.03	Nonsignificant	1.00	0.80	Other	514	1,635
107	MAC.resident_repair	0.03	Nonsignificant	1.00	0.67	Other	796	1,426
108	FIB.skin_sheath	0.03	Nonsignificant	0.91	1.09	Other	49	118
109	EPI.renal_distal_tubule	0.03	Nonsignificant	1.00	0.55	Other	133	361
110	T.CD4_Trm	0.03	Nonsignificant	0.98	1.02	Other	176	363
111	T.CD8_naive	0.03	Nonsignificant	1.00	0.97	Other	317	708
112	MUSC.muscle_stem_cell	0.03	Nonsignificant	—	—	Other	4	18
113	FIB.skin_tenogenic	0.03	Nonsignificant	—	0.94	Other	108	227
114	EPI.colonocyte	0.03	Nonsignificant	1.00	0.45	Other	294	815
115	ILC2.innate_lymphoid_cell_2	0.02	Nonsignificant	—	—	Other	2	0
116	T.CD4_Th2	0.02	Nonsignificant	—	0.78	Other	1	2
117	T.CD4_Treg	0.02	Nonsignificant	1.00	0.87	Other	244	511
118	PERI.pericyte	0.02	Nonsignificant	—	—	Other	117	0
119	T.gamma_delta	0.02	Nonsignificant	0.64	1.09	Other	588	1,078
120	FIB.suburothelial	0.02	Nonsignificant	1.00	0.87	Other	122	432
121	FIB.skin_papillary	0.01	Nonsignificant	—	0.66	Other	0	0
122	ASPC.adipose_stem_and_progenitor_cell	0.01	Nonsignificant	—	—	Other	324	930
123	T.CD4_Tem	0.01	Nonsignificant	1.00	0.90	Other	365	697
124	EPI.thymic_medullary	0.01	Nonsignificant	1.00	0.40	Other	26	133
125	FIB.adventitial	0.01	Nonsignificant	1.00	0.77	Other	268	1,447
126	T.CD8_Trm	0.01	Nonsignificant	1.00	0.97	Other	211	346
127	EPI.salivary_myoepithelial	8.27e-03	Nonsignificant	1.00	0.38	Other	191	714
128	FIB.interstitial	7.73e-03	Nonsignificant	1.00	0.66	Other	288	940
129	T.CD8_Tcm	7.07e-03	Nonsignificant	1.00	0.89	Other	460	926
130	FIB.barrier_secretory	6.80e-03	Nonsignificant	1.00	0.93	Other	81	228
131	EPI.skin_hair_follicle_bulge	6.60e-03	Nonsignificant	1.00	0.39	Other	51	178
132	T.CD8_transitional	6.22e-03	Nonsignificant	1.00	0.89	Other	497	932
133	FIB.neurolectin_mucosa	6.21e-03	Nonsignificant	1.00	0.70	Other	133	394
134	EPI.lung_multiciliated	5.97e-03	Nonsignificant	1.00	0.59	Other	16	49
135	T.CD4_Tcm	5.34e-03	Nonsignificant	1.00	0.77	Other	494	988
136	CHOND.chondrocyte	5.04e-03	Nonsignificant	—	—	Other	519	730
137	NK.natural_killer_cell	4.92e-03	Nonsignificant	—	—	Other	1,204	2,045
138	EPI.lung_club_secretory	4.82e-03	Nonsignificant	1.00	0.41	Other	5	14
139	EPI.skin_appendage_keratinocyte	4.75e-03	Nonsignificant	1.00	0.36	Other	87	222
140	ADIPO.adipocyte	3.46e-03	Nonsignificant	—	—	Other	20	62
141	MESO.mesothelial_cell	2.95e-03	Nonsignificant	—	—	Other	2	18
142	EPI.renal_proximal_tubule	2.76e-03	Nonsignificant	1.00	0.38	Other	525	806
143	EPI.skin_hair_follicle_companion	2.47e-03	Nonsignificant	—	0.00	Other	8	12
144	EPI.renal_immature_ureteric_bud	2.24e-03	Nonsignificant	1.00	0.36	Other	217	569
145	T.MAIT	1.94e-03	Nonsignificant	0.64	1.11	Other	469	855
146	EPI.renal_principal_cell	1.63e-03	Nonsignificant	1.00	0.28	Other	207	403
147	EC.heart_remodeling	1.22e-03	Nonsignificant	1.00	0.35	Other	569	1,594
148	T.CD8_Tem	1.09e-03	Nonsignificant	1.00	0.94	Other	1,083	1,857
149	T.CD4_cytotoxic	6.40e-04	Nonsignificant	1.00	0.56	Other	855	1,493
150	B.germinal_center	5.73e-04	Nonsignificant	1.00	0.40	Other	233	655
151	EPI.salivary_mucous_acinar	2.69e-06	Nonsignificant	1.00	0.02	Other	639	1,189
152	EPI.thymic_cortical	2.44e-06	Nonsignificant	1.00	0.16	Other	442	824

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.esophageal_suprabasal.proliferative_G2M	63.13	Significant	—	2.10	—	0	0
2	OLG.reactive_repair	57.34	Significant	2.37e-05	2.79	—	385	385
3	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	55.77	Significant	—	0.73	—	0	0
4	OLG.regulatory	50.29	Significant	3.69e-04	2.15	—	353	73
5	OLG.vesicle_trafficking	49.12	Significant	0.40	1.29	—	124	10
6	OLG.stress	48.28	Significant	0.06	1.69	—	232	8
7	OLG.regulatory_activated	45.87	Significant	0.53	1.11	Relevant	196	614
8	OLG.myelinating_stress	41.03	Significant	1.00	0.42	—	232	62
9	OLG.myelinating_mature	38.19	Significant	1.00	0.05	—	363	94
10	EPI.esophageal_suprabasal.proliferative_S	38.05	Significant	—	0.82	—	26	41
11	EPI.esophageal_suprabasal.proliferative_exit	37.17	Significant	—	0.85	—	0	0
12	EPI.esophageal_suprabasal.basal_transitional	36.29	Significant	0.32	1.48	—	44	67
13	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	30.37	Significant	—	0.00	—	0	0
14	HPC.MPP_activated	29.32	Significant	—	1.98	—	0	0
15	NEU.EXC_IT.adhesion	26.20	Significant	4.70e-04	2.35	—	252	108
16	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	22.62	Significant	—	0.00	—	0	0
17	EPI.esophageal_suprabasal.differentiating_keratin	21.67	Significant	1.00	0.00	—	131	61
18	EPI.hepatic_ductular_cholangiocyte.secretory_transport	20.69	Significant	—	1.32	—	0	0
19	NEU.EXC_CT.Ca2_sensor	19.63	Significant	—	1.32	—	0	0
20	EPI.hepatic_ductular_cholangiocyte.polarity	18.74	Significant	—	0.70	—	0	0
21	MONO.CD14.cord_tolerance	18.70	Significant	5.25e-11	1.84	Specific	864	753
22	IPSC.stress	18.61	Significant	0.02	1.75	Relevant	0	0
23	IPSC.neural_primed	18.59	Significant	3.24e-03	1.73	—	0	0
24	NEU.EXC_NTNG1.nuclear_reg	17.99	Significant	—	0.67	—	0	0
25	HPC.MEP	17.96	Significant	4.82e-03	1.85	Specific	599	1,195
26	EPI.esophageal_basal.junctional_barrier	17.62	Significant	—	1.21	Relevant	0	0
27	IPSC.mesenchymal_primed	17.57	Significant	2.63e-05	1.89	—	0	0
28	NEU.EXC_IT.guidance	17.36	Significant	0.08	1.69	—	274	63
29	EPI.skin_keratinocyte_proliferating.early_spinous_transition	16.97	Significant	—	0.87	Specific	135	290
30	NEU.EXC_IT.transitional	16.97	Significant	0.60	1.21	—	237	142
31	PLAT.megakaryocytic	16.80	Significant	—	0.97	Relevant	0	0
32	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	16.52	Significant	—	0.79	—	0	0
33	IPSC.proliferative	16.33	Significant	2.17e-03	1.60	—	0	0
34	IPSC.midbrain_primed	16.11	Significant	0.53	1.23	Relevant	0	0
35	EPI.pancreatic_ductal_bicarbonate.inflammatory	15.28	Significant	0.02	2.22	Specific	14	32
36	EPI.hepatic_ductular_cholangiocyte.ion_transport	15.17	Significant	—	0.40	Relevant	0	0
37	NEU.INH_PVALB.nuclear_reg	15.04	Significant	0.04	2.07	—	25	12
38	EPI.skin_interfollicular_spinous.early_differentiation	14.88	Significant	0.13	1.72	—	89	19
39	NEU.INH_PVALB.serotonergic	14.69	Significant	—	0.42	—	0	0
40	EPI.skin_interfollicular_spinous.stress_UPR	14.68	Significant	—	0.56	—	0	0
41	NEU.EXC_CT.Ca2_signaling	14.29	Significant	—	0.14	—	68	17
42	EPI.skin_interfollicular_spinous.stress_oxidative	14.27	Significant	—	0.70	—	0	0
43	EPI.tracheal_suprabasal.transitional_wound	14.05	Significant	—	0.43	—	16	1
44	NEU.INH_PVALB.neuromodulatory	13.89	Significant	—	0.41	—	0	0
45	NEU.EXC_IT.callosal	13.82	Significant	1.00	0.50	—	286	119
46	NEU.EXC_CT.projector	13.78	Significant	0.41	1.09	—	87	26
47	NEU.INH_PVALB.fastspike	13.75	Significant	—	0.21	—	24	22
48	EPI.ectocervical_granular.proliferative_basal	13.70	Significant	—	1.15	Relevant	0	0
49	EPI.skin_interfollicular_spinous.baseline	13.32	Significant	0.62	1.06	—	35	3
50	NEU.EXC_SYT2.nuclear_reg	13.32	Significant	—	0.00	—	0	0
51	NEU.EXC_IT.structural	13.31	Significant	1.00	0.39	—	171	41
52	EPI.skin_interfollicular_spinous.proliferative	13.12	Significant	—	0.14	—	0	0
53	EPI.pancreatic_ductal_bicarbonate.activated	12.68	Significant	0.11	1.80	—	10	7
54	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	12.65	Significant	—	0.00	—	5	3
55	HPC.MPP_IEG	12.14	Significant	0.75	1.10	—	45	46
56	NEU.EXC_SYT2.synaptic	11.44	Significant	—	0.00	—	0	0
57	ASTRO.synaptic_interaction	11.40	Significant	1.32e-04	2.36	Specific	76	334
58	IPSC.mesendo_primed	11.15	Significant	1.00	0.45	—	0	0
59	IPSC.axial_identity_primed	11.03	Significant	1.00	0.47	—	0	0
60	IPSC.stromal_primed	10.82	Significant	1.00	0.20	—	0	0
61	EPI.pancreatic_ductal_bicarbonate.baseline	10.73	Significant	0.24	1.43	Relevant	11	42
62	IPSC.canonical_pluripotent	10.60	Significant	1.00	0.20	—	0	0
63	EPI.pancreatic_islet.delta	10.09	Significant	—	0.67	Relevant	0	0
64	NEU.EXC_CT.remodeling	9.84	Significant	—	0.00	—	23	1
65	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	9.76	Significant	—	0.04	Relevant	0	0
66	NEU.EXC_IT.neuromodulated	9.40	Significant	1.00	0.04	—	176	116
67	ASTRO.hypoxia_angiogenic	9.38	Significant	0.19	1.82	Relevant	5	18
68	DC.pDC.baseline	9.30	Significant	0.61	1.10	Relevant	88	123
69	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	9.25	Significant	—	0.73	—	0	0
70	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	9.03	Significant	0.93	0.71	Relevant	219	533
71	OPC.homeostatic	8.99	Significant	3.57e-04	2.57	—	394	160
72	NEU.INH_PVALB.chandelier	8.97	Significant	1.00	0.00	—	19	16
73	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	8.86	Significant	—	0.00	Relevant	49	237
74	NEU.EXC_NTNG1.synaptic	8.74	Significant	—	0.00	—	0	0
75	EPI.tracheal_basal.homeostatic_progenitor	8.67	Significant	0.14	1.70	—	285	74
76	NEU.INH_PVALB.metabotropic	8.62	Significant	—	0.00	—	0	0
77	EPI.pancreatic_acinar.quiet_dedifferentiation	8.61	Significant	3.49e-04	1.94	Specific	142	171
78	EPI.skin_interfollicular_spinous.transition_basal	8.55	Significant	0.99	0.11	—	100	127
79	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	8.52	Significant	—	0.00	—	6	9
80	DC.pDC.immature_metabolic	8.44	Significant	0.15	1.65	Relevant	78	124
81	EPI.hepatic_ductular_cholangiocyte.stress	8.28	Significant	—	0.00	—	0	0
82	HPC.LMPP	8.26	Significant	0.97	0.76	—	65	31
83	ASTRO.neuromodulatory	8.05	Significant	0.29	1.52	Relevant	34	172
84	EPI.pancreatic_islet.beta	7.83	Significant	0.20	1.24	Relevant	42	57
85	IPSC.mesodermal_primed	7.73	Significant	1.00	0.11	—	0	0
86	EPI.skin_keratinocyte_basal.spinous_transition	7.66	Significant	—	0.97	Relevant	0	0
87	EPI.esophageal_basal.activated_progenitor	7.60	Significant	1.00	0.00	—	1	0
88	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	7.58	Significant	0.97	0.20	Relevant	40	191
89	DC.cDC2.proliferative	7.43	Significant	—	0.63	Relevant	39	71
90	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	7.37	Significant	—	0.00	—	0	0
91	EPI.skin_interfollicular_spinous.upper_lipid	7.29	Significant	—	0.00	—	6	6
92	EPI.endocervical_secretory.squamous_barrier	7.26	Significant	—	0.67	Relevant	0	0
93	IPSC.neuroendocrine_primed	7.22	Significant	—	0.00	—	0	0
94	SCHWN.axon_contact_cardiac	7.22	Significant	0.04	1.71	Relevant	18	63
95	EPI.bile_duct_cholangiocyte.inflammatory_APC	7.10	Significant	—	0.07	—	2	0
96	MAC.MDM.APC_dendritic	6.93	Significant	0.37	1.28	Relevant	48	15
97	EPI.tracheal_suprabasal.secretory_immune	6.90	Significant	—	0.00	Relevant	0	0
98	EPI.skin_keratinocyte_basal.transit_amplifying	6.89	Significant	—	0.00	Relevant	0	0
99	EPI.colonic_tuft.homeostatic	6.87	Significant	—	0.42	Relevant	0	0
100	DC.cDC2.migratory	6.81	Significant	0.26	1.23	Other	185	39
101	ASTRO.immature_lipid	6.79	Significant	0.87	0.92	Relevant	23	113
102	ASTRO.stress_mito	6.60	Significant	0.87	0.85	—	47	110
103	NEU.INH_VIP.cannabinoid	6.58	Significant	—	1.26	—	0	0
104	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	6.36	Significant	—	0.00	Relevant	0	0
105	EPI.tracheal_basal.activated_stress	6.29	Significant	1.00	0.00	—	32	0
106	EPI.bile_duct_cholangiocyte.secretory_mucin	6.24	Significant	—	0.00	Relevant	7	12
107	DC.cDC2.monocyte_like	6.17	Significant	0.26	1.23	Other	1,285	791
108	MEL.mature_oxidative_traffic	6.11	Significant	5.20e-04	2.36	Specific	247	285
109	DC.cDC2.tolerogenic_regulatory	6.11	Significant	0.84	0.88	Other	44	4
110	ASTRO.stress_acute	6.05	Significant	0.87	0.83	—	60	56
111	ASTRO.A2_reactive	6.00	Significant	0.87	0.84	Relevant	10	37
112	OPC.proliferative_immune_interact	5.96	Significant	0.99	0.49	Relevant	180	373
113	EPI.extrahepatic_cholangiocyte.barrier_interface	5.87	Significant	—	0.73	Relevant	0	0
114	OPC.premyelinating	5.66	Significant	0.99	0.12	—	185	12
115	EPI.pancreatic_ductal_bicarbonate.stress	5.63	Significant	—	0.00	Other	12	33
116	HEP.periportal_metabolic.inflammatory_activated	5.51	Significant	0.06	1.31	Other	712	1,610
117	DC.pDC.poised_migratory	5.39	Nominal	0.97	0.19	Other	54	95
118	EPI.skin_keratinocyte_proliferating.anchor_remodel	5.37	Nominal	—	0.00	Other	0	0
119	ASTRO.homeostatic	5.34	Nominal	0.99	0.57	Other	200	431
120	MEL.dedifferentiated_migratory	5.33	Nominal	—	0.27	Other	0	0
121	EPI.pancreatic_acinar.baseline	5.28	Nominal	0.04	1.52	Other	274	163
122	EPI.pancreatic_acinar.inflammatory_regenerative	5.23	Nominal	0.69	1.07	Other	25	113
123	HEP.periportal_metabolic.acute_phase_barrier	5.17	Nominal	0.33	1.19	Other	533	138
124	IPSC.endoderm_primed	5.11	Nominal	1.00	0.65	Other	0	0
125	ASTRO.A1_reactive	5.09	Nominal	1.00	0.09	Other	433	394
126	MEL.stress_glucocorticoid	5.09	Nominal	0.77	0.96	Other	11	34
127	NEU.INH_VIP.nuclear_reg	5.06	Nominal	—	0.81	Other	20	4
128	EPI.cervical_suprabasal.inflammatory_repair	5.04	Nominal	—	0.42	Other	0	0
129	DC.cDC1.proliferative	4.99	Nominal	—	1.53	Other	0	0
130	NEU.INH_VIP.matrix	4.98	Nominal	—	0.71	Other	24	77
131	EPI.pancreatic_acinar.stress	4.90	Nominal	0.69	1.04	Other	28	28
132	HPC.GMP_inflammatory	4.74	Nominal	0.97	0.39	Other	20	10
133	DC.cDC2.adhesion_signaling	4.63	Nominal	0.71	1.08	Other	35	9
134	MAC.MDM.inflammatory_phagocytic	4.49	Nominal	0.42	1.15	Other	199	52
135	EPI.skin_interfollicular_spinous.inflammatory	4.41	Nominal	—	0.00	Other	0	0
136	NEU.INH_VIP.excitatory_coupled	4.21	Nominal	—	0.35	Other	13	0
137	EPI.colonic_enteroendocrine.progenitor	4.20	Nominal	—	0.97	Other	0	0
138	DC.cDC2.pro_inflammatory	4.16	Nominal	0.84	0.78	Other	3	5
139	SCHWN.translation_boost	4.02	Nominal	—	0.00	Other	8	1
140	EPI.cervical_suprabasal.secretory_vesicle	3.97	Nominal	—	0.00	Other	0	0
141	NEU.INH_VIP.opioid	3.94	Nominal	—	0.15	Other	50	9
142	EPI.colonic_tuft.activated	3.92	Nominal	—	0.00	Other	0	0
143	CM.inflammatory	3.83	Nominal	—	2.83	Other	0	0
144	MEL.secretory_quiescent	3.77	Nominal	0.99	0.14	Other	19	13
145	MONO.CD14.baseline	3.67	Nominal	2.26e-07	1.32	Other	2,268	76
146	DC.cDC2.antiviral	3.66	Nominal	0.84	0.97	Other	100	37
147	EC.lymphatic.activated	3.35	Nominal	0.56	1.07	Other	47	73
148	NEU.INH_VIP.canonical_disinhibitory	3.18	Nominal	0.88	0.47	Other	59	38
149	NEU.INH_VIP.develop_niche	3.07	Nominal	—	0.00	Other	0	0
150	EPI.endocervical_secretory.secretory_translocon	3.06	Nominal	—	0.00	Other	0	0
151	EPI.salivary_duct_excretory.stress	3.06	Nominal	0.63	1.20	Other	33	68
152	DC.cDC1.cross_presenting	3.05	Nominal	—	0.36	Other	0	0
153	NEU.INH_VIP.regulatory_remodeling	2.96	Nonsignificant	—	0.00	Other	6	1
154	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	2.91	Nonsignificant	—	1.15	Other	0	0
155	DC.cDC1.activated	2.88	Nonsignificant	—	0.00	Other	0	0
156	EPI.skin_keratinocyte_proliferating.detox_repair	2.82	Nonsignificant	—	0.00	Other	0	0
157	MONO.CD14.inflammatory	2.73	Nonsignificant	1.00	0.79	Other	92	134
158	NEU.INH_VIP.serotonergic	2.65	Nonsignificant	—	0.00	Other	9	2
159	GRNLSA.angiocrine_mechanosensory	2.65	Nonsignificant	—	1.89	Other	0	0
160	HEP.periportal_metabolic.stress_checkpoint	2.49	Nonsignificant	0.90	0.95	Other	234	786
161	EC.lymphatic.tip_migratory	2.43	Nonsignificant	0.43	1.21	Other	23	37
162	DC.cDC1.homeostatic_inhibitory	2.34	Nonsignificant	—	0.00	Other	0	0
163	THYMO.proliferative_G2M	2.27	Nonsignificant	—	1.88	Other	164	413
164	EPI.salivary_duct_excretory.baseline	2.24	Nonsignificant	0.78	0.58	Other	23	57
165	HEP.periportal_metabolic.apolipoprotein_secretory	2.23	Nonsignificant	0.90	1.03	Other	43	110
166	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.23	Nonsignificant	—	0.00	Other	0	0
167	MONO.CD14.platelet_bound	2.21	Nonsignificant	1.00	0.72	Other	964	176
168	EPI.pancreatic_ductal_perivascular.baseline	2.18	Nonsignificant	7.70e-03	2.41	Other	1	5
169	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	2.17	Nonsignificant	0.20	1.33	Other	449	1,034
170	MAC.kupffer.monocyte_like	2.11	Nonsignificant	—	0.00	Other	0	0
171	NEU.INH_LAMP5.exc_inh_balance	2.08	Nonsignificant	—	0.94	Other	46	2
172	MAC.MDM.LAM_like	2.07	Nonsignificant	1.00	0.57	Other	12	14
173	HEP.periportal_metabolic.xenobiotic_detox	2.06	Nonsignificant	0.90	0.96	Other	1,440	139
174	MEL.neurotrophic_migratory	2.05	Nonsignificant	—	0.00	Other	0	0
175	NEU.INH_VIP.LAMP5_hybrid	2.05	Nonsignificant	—	0.00	Other	1	9
176	EPI.pancreatic_acinar.metabolic_onecarbon	1.97	Nonsignificant	1.00	0.12	Other	287	328
177	SCHWN.reactive_inflammatory	1.96	Nonsignificant	—	0.00	Other	0	0
178	T.CD4_naive.activated_stress	1.89	Nonsignificant	0.03	1.59	Other	339	429
179	EC.lymphatic.baseline	1.78	Nonsignificant	0.72	0.96	Other	38	72
180	HPC.GMP_granulocytic	1.71	Nonsignificant	—	0.00	Other	3	3
181	PLAT.adhesion	1.70	Nonsignificant	—	0.00	Other	0	0
182	MAC.kupffer.fibrogenic	1.65	Nonsignificant	—	0.73	Other	0	0
183	SKM.type_1_slow.oxidative	1.65	Nonsignificant	0.45	1.19	Other	802	251
184	SKM.type_1_slow.contractile	1.64	Nonsignificant	0.10	1.76	Other	596	8
185	EPI.pancreatic_acinar.adhesion_remodeling	1.64	Nonsignificant	1.00	0.07	Other	210	784
186	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.58	Nonsignificant	—	0.00	Other	0	0
187	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	1.51	Nonsignificant	—	0.00	Other	0	0
188	HEP.periportal_metabolic.canonical_urea_cycle	1.50	Nonsignificant	0.97	0.90	Other	1,464	269
189	EPI.colonic_enteroendocrine.Lcell_peptide	1.50	Nonsignificant	—	0.00	Other	0	0
190	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	1.49	Nonsignificant	—	0.00	Other	0	0
191	EPI.ileal_goblet.stress_metallothionein	1.44	Nonsignificant	—	0.59	Other	4	11
192	THYMO.proliferative_S	1.40	Nonsignificant	0.87	1.11	Other	163	418
193	MAC.kupffer.inflammatory	1.40	Nonsignificant	—	0.77	Other	7	4
194	EPI.pancreatic_ductal_perivascular.protective_antioxidant	1.39	Nonsignificant	—	0.00	Other	11	69
195	MG.baseline	1.39	Nonsignificant	0.27	1.50	Other	16	5
196	GRNLSA.proliferative_migratory	1.38	Nonsignificant	0.06	1.63	Other	248	292
197	NEU.INH_VIP.enkephalinergic	1.36	Nonsignificant	—	0.00	Other	0	0
198	MONO.CD14.remodeling	1.34	Nonsignificant	1.00	0.38	Other	2,373	295
199	EPI.skin_keratinocyte_progenitor.activated_stress	1.34	Nonsignificant	—	0.00	Other	0	0
200	GRNLSA.EMT_insulin_signaling	1.33	Nonsignificant	0.42	1.37	Other	47	84
201	EPI.ileal_goblet.baseline	1.33	Nonsignificant	0.66	1.12	Other	16	2
202	MG.phagocytic_APC	1.30	Nonsignificant	0.56	1.13	Other	25	8
203	MG.expanding	1.26	Nonsignificant	0.84	0.59	Other	2	1
204	EPI.skin_sebaceous_duct_luminal.detox_repair	1.23	Nonsignificant	0.04	1.60	Other	137	94
205	EPI.ileal_goblet.inflammatory_mucin	1.22	Nonsignificant	0.66	0.80	Other	6	9
206	EPI.alveolar_type_1.baseline	1.20	Nonsignificant	0.10	1.66	Other	8	0
207	DC.cDC1.baseline	1.14	Nonsignificant	—	0.00	Other	0	0
208	HPC.CLP_B_primed	1.09	Nonsignificant	—	0.00	Other	0	0
209	DC.mig.baseline	1.08	Nonsignificant	—	0.00	Other	1	0
210	SKM.type_1_slow.glycolytic	1.03	Nonsignificant	1.00	0.00	Other	362	647
211	MONO.CD16.baseline	1.00	Nonsignificant	0.08	1.26	Other	50	1
212	EPI.salivary_intercalated_defense.inflammatory	0.94	Nonsignificant	0.01	1.54	Other	152	360
213	MAC.MDM.complement_resolving	0.87	Nonsignificant	1.00	0.09	Other	440	860
214	GRNLSA.stress_metabolic	0.86	Nonsignificant	—	0.34	Other	1	2
215	HEP.periportal_metabolic.stress_chaperone	0.83	Nonsignificant	—	0.00	Other	66	128
216	PC.IgG_systemic.interacting	0.82	Nonsignificant	0.31	1.37	Other	0	0
217	EPI.skin_follicular_keratinizing.root_infundibulum	0.77	Nonsignificant	—	1.02	Other	0	0
218	NEU.INH_LAMP5.projecting	0.75	Nonsignificant	—	0.00	Other	0	0
219	FIB.transitioning.ISG_primed_interface	0.75	Nonsignificant	—	0.56	Other	17	80
220	EPI.salivary_intercalated_defense.basal_EMT	0.72	Nonsignificant	—	0.67	Other	0	0
221	MONO.CD16.patrolling	0.72	Nonsignificant	0.15	1.14	Other	797	216
222	MONO.CD16.hepatic_mac_like	0.71	Nonsignificant	9.16e-03	1.39	Other	803	117
223	NEU.INH_LAMP5.glial_interface	0.71	Nonsignificant	—	0.00	Other	0	0
224	MAC.alveolar.scavenging_endocytic	0.70	Nonsignificant	—	1.53	Other	140	283
225	MONO.CD16.inflammatory	0.70	Nonsignificant	0.08	1.21	Other	1,640	168
226	GRNLSA.lipid_hypoxia	0.70	Nonsignificant	0.99	0.90	Other	28	0
227	EPI.salivary_serous_acinar.quiescent	0.68	Nonsignificant	0.19	1.16	Other	178	493
228	EPI.ectocervical_granular.inflammatory	0.65	Nonsignificant	—	0.32	Other	0	0
229	NEU.INH_LAMP5.rosehip	0.64	Nonsignificant	—	0.00	Other	0	0
230	EPI.ileal_goblet.immature	0.63	Nonsignificant	—	0.00	Other	0	0
231	EPI.skin_follicular_keratinizing.transit_amplifying	0.62	Nonsignificant	—	0.00	Other	21	49
232	MAC.kupffer.metabolic	0.61	Nonsignificant	—	0.17	Other	25	36
233	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	0.58	Nonsignificant	—	1.21	Other	0	0
234	MAC.proliferating.stress	0.58	Nonsignificant	—	0.31	Other	87	136
235	DC.cDC2.lipid_metabolic	0.58	Nonsignificant	—	0.00	Other	0	0
236	GRANU.MAST.activated_repair	0.56	Nonsignificant	—	0.33	Other	0	1
237	EPI.colonocyte.distal_absorptive	0.56	Nonsignificant	—	2.20	Other	0	0
238	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.55	Nonsignificant	—	0.80	Other	105	368
239	MONO.CD14.APC_like	0.53	Nonsignificant	1.00	0.59	Other	1,686	2,493
240	MAC.resident_iron.APC_iron_sensing	0.53	Nonsignificant	0.82	1.13	Other	211	114
241	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.52	Nonsignificant	—	0.37	Other	0	0
242	FIB.reticular.immune_interface	0.52	Nonsignificant	—	0.80	Other	1	6
243	PC.IgG_systemic.metabolic	0.51	Nonsignificant	0.78	1.01	Other	46	63
244	GRNLSA.secretory_remodeling	0.51	Nonsignificant	0.99	0.78	Other	90	25
245	SKM.type_2_fast.oxidative_IIa	0.50	Nonsignificant	0.53	1.22	Other	946	56
246	MONO.CD14.repair_M2_like	0.50	Nonsignificant	1.00	0.35	Other	550	1,495
247	PC.IgG_systemic.stress	0.48	Nonsignificant	—	0.39	Other	1	5
248	GRNLSA.cholesterol_mevalonate	0.48	Nonsignificant	0.99	0.59	Other	9	4
249	HEP.periportal_metabolic.urea_onecarbon_secretory	0.47	Nonsignificant	1.00	0.47	Other	1,332	3,053
250	MAC.kupffer.tolerogenic	0.46	Nonsignificant	—	0.00	Other	45	49
251	B.naive.restrained	0.45	Nonsignificant	3.51e-03	1.19	Other	183	353
252	GRANU.MAST.resting_granule	0.45	Nonsignificant	—	0.29	Other	0	0
253	EPI.gastric_foveolar.baseline	0.44	Nonsignificant	—	0.00	Other	0	0
254	SKM.type_2_fast.glycolytic_IIx_IIb	0.44	Nonsignificant	0.84	0.61	Other	565	1,482
255	EPI.ileal_enterocyte_absorptive.brush_border	0.44	Nonsignificant	9.93e-05	2.62	Other	580	1,717
256	MONO.CD16.platelet_bound	0.43	Nonsignificant	0.70	0.88	Other	372	508
257	EPI.tracheal_submucosal_gland.ductal_luminal	0.43	Nonsignificant	—	0.00	Other	0	0
258	CM.mechano_activated	0.43	Nonsignificant	0.05	1.81	Other	205	134
259	FIB.transitioning.matrix_stress	0.42	Nonsignificant	—	0.00	Other	47	138
260	EPI.skin_follicular_keratinizing.upper_infundibulum	0.42	Nonsignificant	—	0.00	Other	8	2
261	EC.capillary.angiogenic_tip	0.40	Nonsignificant	0.45	1.23	Other	186	218
262	SMC.contractile	0.39	Nonsignificant	4.90e-05	1.51	Other	80	588
263	EC.liver_sinusoidal.remodeling_lipotoxicity	0.38	Nonsignificant	—	1.25	Other	90	58
264	B.memory.preactivated	0.37	Nonsignificant	0.06	1.20	Other	173	174
265	HEP.canalicular_transport.pericentral_like_hypoxia	0.36	Nonsignificant	0.17	1.34	Other	326	8
266	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.36	Nonsignificant	6.49e-03	1.39	Other	322	317
267	HEP.canalicular_transport.injury_stress	0.36	Nonsignificant	0.17	1.33	Other	289	24
268	FIB.hepatic_stellate_cell.contractile	0.34	Nonsignificant	—	1.15	Other	0	0
269	GRNLSA.p53_damage	0.34	Nonsignificant	—	0.00	Other	13	10
270	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.33	Nonsignificant	—	0.31	Other	10	20
271	EPI.alveolar_type_2.injury_primed	0.33	Nonsignificant	0.04	1.82	Other	434	245
272	EPI.ileal_enterocyte_crypt.secretory_precursor	0.33	Nonsignificant	—	1.68	Other	0	0
273	HEP.canalicular_transport.ductular_like_transition	0.32	Nonsignificant	0.34	1.20	Other	400	87
274	B.age_associated.activated	0.32	Nonsignificant	—	0.23	Other	18	22
275	FIB.hepatic_stellate_cell.fibrogenic	0.32	Nonsignificant	—	0.00	Other	0	0
276	MAC.alveolar.inflammatory	0.32	Nonsignificant	0.26	1.36	Other	208	312
277	HEP.canalicular_transport.baseline	0.31	Nonsignificant	0.82	0.97	Other	199	477
278	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.30	Nonsignificant	—	1.52	Other	0	0
279	EPI.tracheal_submucosal_gland.acinar_serous	0.30	Nonsignificant	—	0.00	Other	0	0
280	B.age_associated.migratory	0.29	Nonsignificant	0.46	1.03	Other	2	2
281	EPI.pancreatic_ductal_progenitor.baseline	0.28	Nonsignificant	0.92	0.39	Other	179	702
282	MAC.alveolar.capillary_interacting	0.28	Nonsignificant	1.00	0.93	Other	113	181
283	EPI.ileal_enterocyte_absorptive.villus_tip	0.27	Nonsignificant	0.99	0.16	Other	4	3
284	FIB.tracheal_subepithelial.baseline	0.27	Nonsignificant	—	0.00	Other	0	0
285	FIB.hepatic_stellate_cell.inflammatory	0.27	Nonsignificant	—	0.00	Other	0	0
286	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.26	Nonsignificant	0.96	0.21	Other	2	9
287	EPI.pancreatic_ductal_progenitor.ADM_like	0.25	Nonsignificant	—	0.00	Other	0	0
288	EPI.ileal_bile_transport.detox_transcytosis	0.24	Nonsignificant	—	0.00	Other	0	1
289	GRNLSA.chemokine_mechanosensory	0.24	Nonsignificant	0.99	0.09	Other	1	0
290	EPI.ileal_bile_transport.absorptive_xenobiotic	0.24	Nonsignificant	0.16	1.54	Other	11	12
291	EPI.alveolar_type_2.stress_response	0.24	Nonsignificant	0.99	0.82	Other	675	1,562
292	B.age_associated.naive_transitional	0.23	Nonsignificant	—	0.00	Other	0	0
293	MAC.resident_iron.stress_tolerogenic	0.23	Nonsignificant	—	1.22	Other	0	0
294	EPI.ectocervical_granular.immune_interact	0.23	Nonsignificant	—	0.00	Other	0	0
295	FIB.transitioning.secretory_procollagen	0.23	Nonsignificant	—	0.00	Other	0	0
296	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.22	Nonsignificant	—	0.83	Other	19	54
297	EPI.salivary_duct_ion_transport.baseline	0.21	Nonsignificant	—	—	Other	0	0
298	FIB.perivascular_interface.vasomotor_tone	0.20	Nonsignificant	—	1.21	Other	0	0
299	EC.liver_sinusoidal.prostanoid	0.19	Nonsignificant	—	0.20	Other	11	64
300	HEP.canalicular_transport.inflammatory	0.18	Nonsignificant	1.00	0.42	Other	1,335	194
301	EC.lymphatic.valve	0.18	Nonsignificant	—	0.04	Other	0	0
302	PC.IgA_muocsal.activated	0.18	Nonsignificant	0.04	1.21	Other	17	8
303	EC.liver_sinusoidal.stress	0.18	Nonsignificant	—	0.11	Other	413	158
304	GRANU.MAST.activated_acute	0.18	Nonsignificant	—	0.00	Other	0	0
305	FIB.transitioning.motility_remodelling	0.18	Nonsignificant	—	0.00	Other	0	0
306	EPI.renal_thick_ascending_limb.barrier_repair	0.17	Nonsignificant	1.00	0.96	Other	141	284
307	T.CD4_naive.neddylation_mitoprot	0.17	Nonsignificant	0.53	1.27	Other	93	56
308	B.naive.activated	0.17	Nonsignificant	1.00	0.97	Other	77	127
309	EC.arterial.elastic	0.17	Nonsignificant	0.61	1.11	Other	22	45
310	EPI.alveolar_type_2.baseline_surfactant	0.17	Nonsignificant	0.99	0.22	Other	64	9
311	EPI.pancreatic_islet.alpha	0.17	Nonsignificant	—	0.00	Other	152	330
312	EC.liver_sinusoidal.hypoxia_metabolic	0.17	Nonsignificant	0.77	1.10	Other	183	107
313	HEP.pericentral_lipoprotein.UPR_redox	0.16	Nonsignificant	—	0.67	Other	0	0
314	FIB.reticular.stress_metallothionein	0.16	Nonsignificant	—	0.41	Other	3	32
315	T.CD4_Tfh.effector_migratory	0.16	Nonsignificant	0.24	1.23	Other	122	57
316	HEP.canalicular_transport.secretory_ERAD_UPR	0.15	Nonsignificant	1.00	0.64	Other	232	28
317	PC.IgA_muocsal.migratory	0.15	Nonsignificant	0.92	1.02	Other	4	1
318	T.CD4_naive.Treg_like	0.14	Nonsignificant	0.53	1.46	Other	121	72
319	EC.arterial.inflammatory	0.14	Nonsignificant	0.61	1.14	Other	63	50
320	FIB.barrier_purinergic.lipid_secretory	0.14	Nonsignificant	—	0.48	Other	0	0
321	MAC.proliferating.DNA_replication	0.14	Nonsignificant	0.95	0.57	Other	3	6
322	MAC.alveolar.lipid_autophagy	0.14	Nonsignificant	—	0.00	Other	35	44
323	MAC.microglia_like.patrolling_adhesive	0.14	Nonsignificant	—	0.85	Other	0	0
324	MAC.kupffer.stress	0.14	Nonsignificant	1.00	0.13	Other	9	3
325	EPI.skin_keratinocyte_basal.basement_anchoring	0.13	Nonsignificant	—	0.00	Other	0	0
326	EPI.renal_distal_tubule.immune_modulatory	0.12	Nonsignificant	—	1.34	Other	0	0
327	HEP.pericentral_lipoprotein.ApoB_coagulation	0.12	Nonsignificant	—	0.00	Other	0	0
328	B.naive.proteostasis	0.12	Nonsignificant	0.79	1.09	Other	49	69
329	T.CD4_Th17.cytotoxic	0.12	Nonsignificant	0.30	1.21	Other	332	123
330	EC.arterial.metabolic	0.12	Nonsignificant	0.64	1.03	Other	195	159
331	EPI.ileal_enterocyte_crypt.villus_transition	0.11	Nonsignificant	—	0.61	Other	7	10
332	EPI.salivary_serous_acinar.seromucous_like	0.11	Nonsignificant	—	1.19	Other	0	0
333	HEP.acute_phase.stress_secretory	0.11	Nonsignificant	0.99	1.12	Other	26	3
334	MAC.alveolar.biosynthetic_sterol_heme	0.11	Nonsignificant	1.00	0.30	Other	347	40
335	MAC.resident_cardiac.inflammatory_reparative	0.11	Nonsignificant	0.10	1.51	Other	31	96
336	CM.anti_inflammatory	0.11	Nonsignificant	1.00	0.99	Other	424	1,503
337	EPI.alveolar_type_1.activated	0.11	Nonsignificant	—	0.00	Other	0	0
338	HEP.acute_phase.baseline	0.11	Nonsignificant	0.15	1.17	Other	946	19
339	B.naive.antigen_presenting_ready	0.10	Nonsignificant	1.00	1.01	Other	48	73
340	THYMO.SP_CD8_transitional	0.10	Nonsignificant	1.00	1.12	Other	32	75
341	FIB.perivascular_interface.vascular_BM_remodelling	0.10	Nonsignificant	—	0.16	Other	0	0
342	MAC.LAM.inflammatory_APC	0.10	Nonsignificant	0.41	1.06	Other	872	165
343	CM.sarcomere_actin_interface	0.10	Nonsignificant	1.00	1.06	Other	450	78
344	EC.lymphatic.scavenger	0.10	Nonsignificant	1.00	0.52	Other	203	257
345	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.10	Nonsignificant	1.00	0.10	Other	11	22
346	T.CD4_transitional.tissue_enagement	0.10	Nonsignificant	0.07	1.36	Other	5	11
347	PC.IgA_muocsal.plasmablast	0.10	Nonsignificant	0.92	0.92	Other	5	4
348	MAC.resident_cardiac.antigen_presenting	0.10	Nonsignificant	0.10	1.40	Other	52	27
349	PC.IgG_systemic.secretory	0.10	Nonsignificant	1.00	0.11	Other	0	0
350	GRANU.neutrophil.antiviral_endotoxin	0.09	Nonsignificant	—	0.90	Other	0	0
351	B.memory.activated	0.09	Nonsignificant	0.86	1.03	Other	105	29
352	CM.oxidative_phospho	0.09	Nonsignificant	1.00	1.02	Other	266	792
353	CM.mito_proteostasis	0.09	Nonsignificant	1.00	0.70	Other	329	29
354	EC.arterial.homeostatic	0.09	Nonsignificant	0.61	1.08	Other	24	3
355	EPI.renal_intercalated_cell_type_A.acid_secretion	0.08	Nonsignificant	3.39e-03	1.55	Other	12	6
356	GRANU.neutrophil.tissue_patrolling	0.08	Nonsignificant	—	0.00	Other	0	0
357	HEP.acute_phase.proliferative	0.08	Nonsignificant	—	0.61	Other	4	6
358	CM.baseline	0.08	Nonsignificant	1.00	0.58	Other	393	0
359	CM.osmoprotection	0.08	Nonsignificant	1.00	0.77	Other	34	57
360	EC.liver_sinusoidal.secretory_lipoprotein	0.08	Nonsignificant	0.87	0.55	Other	120	70
361	PC.IgA_muocsal.baseline	0.07	Nonsignificant	0.97	0.75	Other	3	5
362	EC.venous.baseline	0.07	Nonsignificant	0.01	1.15	Other	346	807
363	SMC.metabolic	0.07	Nonsignificant	0.99	0.52	Other	14	40
364	EPI.renal_thick_ascending_limb.cation_flux	0.07	Nonsignificant	1.00	0.85	Other	57	95
365	MAC.microglia_like.inflammatory_chemokine	0.07	Nonsignificant	—	0.00	Other	20	32
366	CM.translation_boost_RPL	0.07	Nonsignificant	1.00	0.70	Other	129	1
367	EPI.salivary_myoepithelial.contractile_repair	0.07	Nonsignificant	—	1.65	Other	3	9
368	EC.liver_sinusoidal.inflammatory	0.07	Nonsignificant	—	0.00	Other	223	154
369	NK.immature_bridge	0.07	Nonsignificant	0.99	1.07	Other	117	122
370	CM.contractile_oxphos	0.07	Nonsignificant	1.00	0.75	Other	6	19
371	T.CD4_Treg.tissue_effector	0.07	Nonsignificant	0.06	1.45	Other	16	13
372	EPI.colonocyte.ionocyte_BEST4	0.07	Nonsignificant	1.00	1.39	Other	103	188
373	T.CD8_naive.cytokine_dampened	0.07	Nonsignificant	0.35	1.20	Other	71	4
374	SMC.activated	0.06	Nonsignificant	0.99	0.47	Other	2	5
375	T.CD8_Trm.dendritic_recruiter	0.06	Nonsignificant	0.08	1.33	Other	47	85
376	FIB.perivascular_interface.lipid_shuttle	0.06	Nonsignificant	—	0.00	Other	51	170
377	T.CD4_Tfh.suppression_exhaustion	0.06	Nonsignificant	0.98	1.01	Other	0	2
378	GRANU.neutrophil.primed_degranulation	0.06	Nonsignificant	—	0.00	Other	0	0
379	T.CD4_transitional.APC_interacting	0.06	Nonsignificant	0.36	1.21	Other	10	14
380	EPI.renal_thick_ascending_limb.remodeling	0.06	Nonsignificant	1.00	0.68	Other	152	92
381	EC.arterial.mito_contact	0.05	Nonsignificant	1.00	0.83	Other	14	5
382	MAC.resident_repair.antigen_presenting	0.05	Nonsignificant	0.70	1.05	Other	244	113
383	ILC2.migratory	0.05	Nonsignificant	—	0.80	Other	0	0
384	T.CD4_Trm.baseline	0.05	Nonsignificant	0.72	1.11	Other	31	21
385	PERI.baseline	0.05	Nonsignificant	7.75e-04	1.34	Other	39	66
386	EPI.ileal_enterocyte_crypt.bile_transport	0.05	Nonsignificant	0.92	0.66	Other	2	0
387	T.CD8_naive.splicing_enriched	0.05	Nonsignificant	0.35	1.19	Other	120	16
388	T.CD4_naive.survival_mitoprot	0.05	Nonsignificant	1.00	1.21	Other	13	7
389	EPI.lung_multiciliated.mature_motile_cilia	0.05	Nonsignificant	—	1.53	Other	0	0
390	MAC.resident_repair.chemokine_angiocrine	0.05	Nonsignificant	0.59	1.08	Other	87	138
391	T.CD4_transitional.primed_helper_effector	0.05	Nonsignificant	0.62	1.05	Other	19	43
392	EC.arterial.arteriole_interface	0.04	Nonsignificant	0.64	1.03	Other	31	12
393	FIB.reticular.stromal_niche	0.04	Nonsignificant	0.96	0.38	Other	0	0
394	MAC.alveolar.stress_metabolic	0.04	Nonsignificant	1.00	0.07	Other	116	148
395	FIB.reticular.ECM_builder	0.04	Nonsignificant	—	0.00	Other	0	0
396	MAC.resident_cardiac.phagocytic_homeostasis	0.04	Nonsignificant	1.00	0.21	Other	564	1,221
397	EPI.renal_intercalated_cell_type_B.baseline	0.04	Nonsignificant	—	0.00	Other	3	1
398	MUSC.baseline	0.04	Nonsignificant	0.31	1.54	Other	0	0
399	FIB.skin_neurosecretory.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
400	THYMO.SP_CD4_naive	0.04	Nonsignificant	1.00	0.91	Other	65	75
401	FIB.skin_sheath.ECM_immune	0.04	Nonsignificant	—	0.59	Other	0	0
402	FIB.lung_alveolar.stress_interacting	0.04	Nonsignificant	—	0.97	Other	0	0
403	T.CD4_Trm.activated	0.04	Nonsignificant	0.86	1.10	Other	32	26
404	EPI.skin_sebaceous_duct_luminal.immune_interface	0.04	Nonsignificant	—	0.00	Other	0	0
405	EPI.ileal_enterocyte_crypt.baseline	0.04	Nonsignificant	0.92	0.87	Other	11	6
406	THYMO.DN_preTCR	0.04	Nonsignificant	1.00	0.93	Other	41	71
407	ASPC.adipocyte_capillary_interface	0.04	Nonsignificant	0.69	1.15	Other	21	54
408	FIB.adventitial.inflammatory_activated	0.04	Nonsignificant	0.51	1.16	Other	100	473
409	MAC.resident_repair.stress_iron	0.04	Nonsignificant	0.82	1.05	Other	48	97
410	EPI.ileal_enterocyte_crypt.proliferative_S	0.03	Nonsignificant	0.92	0.69	Other	4	2
411	T.CD4_Th2.tissue_adapted	0.03	Nonsignificant	—	0.97	Other	0	0
412	FIB.lung_alveolar.mito_secretory	0.03	Nonsignificant	—	0.00	Other	0	0
413	B.naive.baseline	0.03	Nonsignificant	1.00	0.87	Other	10	13
414	B.naive.remodeling	0.03	Nonsignificant	1.00	0.83	Other	135	230
415	ASPC.remodeling	0.03	Nonsignificant	0.69	1.08	Other	106	354
416	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.03	Nonsignificant	—	0.00	Other	0	0
417	T.CD4_Trm.stress_adaptive	0.03	Nonsignificant	0.72	1.16	Other	8	22
418	FIB.skin_sheath.stress_chaperone	0.03	Nonsignificant	—	0.00	Other	0	0
419	EPI.thymic_medullary.canonical_alarmin	0.03	Nonsignificant	0.17	1.35	Other	8	17
420	T.CD8_Tcm.gut_homing	0.03	Nonsignificant	0.18	1.39	Other	380	112
421	ASPC.proliferative	0.03	Nonsignificant	0.69	1.25	Other	33	85
422	EC.arterial.ion_pump	0.03	Nonsignificant	0.94	0.92	Other	3	2
423	HEP.acute_phase.hypoxia_lipid	0.03	Nonsignificant	—	0.50	Other	0	0
424	MUSC.activated_migratory	0.03	Nonsignificant	0.83	1.13	Other	6	7
425	HEP.acute_phase.complement_metabolic	0.03	Nonsignificant	1.00	0.83	Other	1,423	3,464
426	T.CD4_Tcm.regulatory_poised	0.03	Nonsignificant	0.66	1.20	Other	2	3
427	B.memory.baseline	0.03	Nonsignificant	1.00	0.77	Other	472	99
428	B.naive.metabolic	0.03	Nonsignificant	1.00	0.77	Other	50	79
429	CM.translation_boost_RPS	0.03	Nonsignificant	1.00	0.09	Other	69	16
430	EC.venous.remodeling_stalk	0.03	Nonsignificant	0.93	0.93	Other	559	566
431	T.CD4_naive.mature_mitoprot	0.03	Nonsignificant	1.00	0.85	Other	212	476
432	T.CD4_Trm.central_like	0.03	Nonsignificant	0.96	0.87	Other	38	31
433	T.CD4_Tfh.canonical_GC_helper	0.03	Nonsignificant	0.98	0.72	Other	1	2
434	FIB.skin_tenogenic.baseline	0.03	Nonsignificant	—	0.00	Other	0	2
435	EC.capillary.inflammatory	0.03	Nonsignificant	0.99	1.01	Other	27	51
436	MAC.LAM.anti_inflammatory	0.03	Nonsignificant	0.72	1.05	Other	86	132
437	HEP.acute_phase.complement_antiviral	0.02	Nonsignificant	1.00	0.79	Other	377	751
438	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.02	Nonsignificant	—	0.31	Other	43	26
439	MAC.LAM.lipid_opsonization	0.02	Nonsignificant	1.00	0.97	Other	45	14
440	ASPC.preadipocyte_lipid_primed	0.02	Nonsignificant	0.04	1.11	Other	331	129
441	T.CD4_transitional.baseline	0.02	Nonsignificant	0.87	0.88	Other	59	97
442	FIB.suburothelial.urothelial_interface	0.02	Nonsignificant	0.04	1.81	Other	9	8
443	T.CD8_naive.nfkb_related	0.02	Nonsignificant	0.83	1.12	Other	1	0
444	EPI.salivary_serous_acinar.secretory_active	0.02	Nonsignificant	0.87	0.89	Other	242	69
445	FIB.skin_sheath.neuro_vascular_interface	0.02	Nonsignificant	—	0.00	Other	0	0
446	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.59	1.11	Other	28	6
447	EC.arterial.arteriole_gas_exchange	0.02	Nonsignificant	1.00	0.65	Other	238	131
448	T.gamma_delta.early_effector	0.02	Nonsignificant	0.72	1.02	Other	89	0
449	T.gamma_delta.cytotoxic_effector	0.02	Nonsignificant	0.54	1.07	Other	349	109
450	T.CD4_naive.mature	0.02	Nonsignificant	1.00	0.80	Other	211	100
451	MAC.microglia_like.phagocytic_redox	0.02	Nonsignificant	—	0.00	Other	0	0
452	T.CD4_transitional.primed_cytotoxic	0.02	Nonsignificant	0.87	0.82	Other	28	30
453	THYMO.SP_CD8_naive_stress	0.02	Nonsignificant	1.00	1.03	Other	1	1
454	THYMO.DP_early_stress	0.02	Nonsignificant	—	0.84	Other	0	0
455	MUSC.quiescent_reservoir	0.02	Nonsignificant	0.98	0.76	Other	2	8
456	T.CD4_Tem.long_term_memory	0.02	Nonsignificant	0.40	1.19	Other	314	587
457	B.memory.migratory	0.02	Nonsignificant	1.00	0.83	Other	123	208
458	CHOND.angiogenic	0.02	Nonsignificant	—	1.46	Other	0	0
459	PERI.inflammatory	0.02	Nonsignificant	0.77	1.03	Other	40	77
460	T.CD4_naive.proteostasis	0.02	Nonsignificant	1.00	1.06	Other	14	9
461	EC.capillary.activated	0.02	Nonsignificant	0.99	0.95	Other	2	5
462	EC.venous.quiescent_homeostatic	0.02	Nonsignificant	0.93	0.90	Other	456	360
463	FIB.suburothelial.inflammatory_prostanoid	0.02	Nonsignificant	—	0.19	Other	0	0
464	MAC.resident_iron.heme_recycling	0.02	Nonsignificant	—	0.00	Other	30	37
465	T.CD8_naive.mito_proteostasis	0.02	Nonsignificant	0.83	1.12	Other	428	100
466	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.02	Nonsignificant	—	0.46	Other	0	0
467	FIB.adventitial.baseline	0.02	Nonsignificant	0.51	1.13	Other	157	278
468	FIB.interstitial.mesenchymal_regulator	0.02	Nonsignificant	0.47	1.16	Other	4	4
469	FIB.suburothelial.contractile_myofibroblast	0.02	Nonsignificant	—	0.12	Other	9	0
470	B.naive.purinergic	0.02	Nonsignificant	1.00	0.62	Other	384	820
471	EC.venous.cardiac_structural	0.02	Nonsignificant	0.93	0.94	Other	102	229
472	T.CD4_naive.survival_neddylation	0.01	Nonsignificant	1.00	0.89	Other	26	38
473	T.CD4_Treg.Tr1_like	0.01	Nonsignificant	—	0.60	Other	8	8
474	EC.capillary.baseline	0.01	Nonsignificant	0.99	0.91	Other	246	560
475	FIB.skin_papillary.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
476	ASPC.inflammatory	0.01	Nonsignificant	0.69	1.10	Other	21	61
477	T.CD4_naive.neddylation	0.01	Nonsignificant	1.00	0.82	Other	104	222
478	T.CD4_naive.homeostatic	0.01	Nonsignificant	1.00	0.66	Other	215	108
479	MUSC.early_activation	0.01	Nonsignificant	0.98	0.11	Other	4	32
480	T.CD8_transitional.Trm_primed	0.01	Nonsignificant	0.38	1.12	Other	108	15
481	T.CD4_naive.purinergic	0.01	Nonsignificant	1.00	0.89	Other	49	1
482	T.CD4_Tfh.precursor_migratory	0.01	Nonsignificant	0.98	0.58	Other	72	27
483	T.CD8_naive.effector_transition	0.01	Nonsignificant	0.90	0.96	Other	35	62
484	T.CD4_naive.survival	0.01	Nonsignificant	1.00	0.91	Other	12	17
485	T.CD4_Trm.cytotoxic_effector	0.01	Nonsignificant	0.96	0.80	Other	118	77
486	EC.arterial.angiogenic_tip	0.01	Nonsignificant	—	0.00	Other	30	37
487	ASPC.stem_like_progenitor	0.01	Nonsignificant	0.93	1.01	Other	300	842
488	FIB.barrier_secretory.homeostasis	0.01	Nonsignificant	—	0.17	Other	0	0
489	T.CD4_naive.proteostasis_mitoprot	0.01	Nonsignificant	1.00	0.63	Other	15	37
490	T.CD8_naive.lipid_synthesis	0.01	Nonsignificant	0.90	0.96	Other	6	4
491	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.01	Nonsignificant	0.39	1.29	Other	7	16
492	EPI.ectocervical_granular.secretory_apocrine	0.01	Nonsignificant	—	0.00	Other	0	0
493	ILC2.activated	0.01	Nonsignificant	—	0.00	Other	0	0
494	FIB.adventitial.adhesion_lipid	0.01	Nonsignificant	0.92	1.04	Other	58	209
495	FIB.neurolectin_mucosa.nerve_interface	0.01	Nonsignificant	—	0.40	Other	4	0
496	EPI.lung_club_secretory.canonical_surfactant	0.01	Nonsignificant	—	0.63	Other	74	104
497	MAC.resident_iron.heme_catabolism	0.01	Nonsignificant	0.82	0.90	Other	30	51
498	EC.venous.adipose_lipid	9.99e-03	Nonsignificant	0.13	1.21	Other	254	476
499	T.CD4_Treg.APC_interactive	9.89e-03	Nonsignificant	1.00	0.67	Other	118	28
500	FIB.interstitial.lipid_matrix	9.79e-03	Nonsignificant	8.45e-03	1.28	Other	258	191
501	T.CD8_Trm.muscosal_Tc17	9.75e-03	Nonsignificant	0.55	1.15	Other	19	38
502	PERI.angiocrine	9.64e-03	Nonsignificant	1.00	0.78	Other	93	102
503	T.CD4_Th17.migratory	9.60e-03	Nonsignificant	0.58	1.08	Other	13	23
504	EPI.skin_sweat_duct_keratinocyte.barrier	9.39e-03	Nonsignificant	—	0.00	Other	0	0
505	T.MAIT.early_activation	9.31e-03	Nonsignificant	0.03	1.33	Other	57	4
506	T.CD8_naive.baseline	9.13e-03	Nonsignificant	0.99	0.68	Other	142	2
507	EC.capillary.postcap_venule	8.98e-03	Nonsignificant	0.99	1.00	Other	355	261
508	CHOND.remodeling	8.93e-03	Nonsignificant	—	0.51	Other	5	0
509	ASPC.niche_keeping_progenitor	8.45e-03	Nonsignificant	0.95	0.90	Other	52	219
510	MAC.resident_iron.redox_metabolic	8.38e-03	Nonsignificant	0.82	0.83	Other	4	4
511	T.CD8_transitional.early	8.20e-03	Nonsignificant	0.66	1.01	Other	327	55
512	ASPC.baseline	8.19e-03	Nonsignificant	0.95	0.94	Other	363	170
513	T.CD8_naive.innate_like	8.13e-03	Nonsignificant	0.90	0.85	Other	10	1
514	FIB.interstitial.immune_interact	8.06e-03	Nonsignificant	0.95	0.97	Other	12	1
515	T.CD4_Tcm.crosstalk_myeloid	8.05e-03	Nonsignificant	0.66	1.16	Other	5	4
516	EPI.skin_hair_follicle_bulge.niche_crosstalk	8.04e-03	Nonsignificant	—	0.16	Other	29	88
517	T.CD8_naive.vesicle_secretory	7.95e-03	Nonsignificant	0.99	0.73	Other	42	0
518	T.CD4_Trm.helper_like	7.95e-03	Nonsignificant	0.96	0.67	Other	84	147
519	B.naive.receptor_recycle	7.94e-03	Nonsignificant	1.00	0.63	Other	51	0
520	ASPC.secretory	7.86e-03	Nonsignificant	0.95	0.90	Other	76	5
521	FIB.interstitial.remodeling	7.86e-03	Nonsignificant	0.95	0.98	Other	31	9
522	FIB.adventitial.mito_secretory	7.59e-03	Nonsignificant	0.92	1.02	Other	21	7
523	ADIPO.inflammatory	7.53e-03	Nonsignificant	—	0.97	Other	0	0
524	EC.capillary.stress	7.22e-03	Nonsignificant	0.99	0.86	Other	44	36
525	T.CD4_naive.resist_bystander	7.07e-03	Nonsignificant	1.00	0.60	Other	40	25
526	EPI.colonocyte.proximal_transport	7.03e-03	Nonsignificant	1.00	1.01	Other	24	12
527	EPI.skin_hair_follicle_bulge.quiescent	6.87e-03	Nonsignificant	0.42	1.09	Other	56	69
528	T.CD8_Trm.inflammatory	6.79e-03	Nonsignificant	0.73	1.03	Other	124	176
529	T.CD4_Tcm.baseline	6.77e-03	Nonsignificant	0.85	1.07	Other	61	31
530	T.CD4_Th2.precursor	6.70e-03	Nonsignificant	—	0.00	Other	0	0
531	CHOND.pro_inflammatory	6.41e-03	Nonsignificant	0.83	0.94	Other	181	351
532	ADIPO.thermogenic	6.28e-03	Nonsignificant	—	0.94	Other	0	0
533	T.CD4_Trm.metal_stress	6.19e-03	Nonsignificant	0.96	0.95	Other	34	58
534	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	6.17e-03	Nonsignificant	—	0.97	Other	0	0
535	EC.capillary.angiocrine	6.16e-03	Nonsignificant	0.99	0.74	Other	250	630
536	EC.venous.activated	6.07e-03	Nonsignificant	0.98	0.73	Other	247	752
537	T.CD4_Tcm.stress	6.06e-03	Nonsignificant	0.85	0.98	Other	5	11
538	MESO.secretory_structural	6.00e-03	Nonsignificant	—	0.96	Other	0	0
539	FIB.neurolectin_mucosa.axon_responsive	5.98e-03	Nonsignificant	0.60	1.04	Other	10	10
540	FIB.suburothelial.homeostasis_matrix	5.81e-03	Nonsignificant	1.00	0.00	Other	258	921
541	T.CD4_Tcm.tissue_homing	5.73e-03	Nonsignificant	0.85	1.03	Other	78	46
542	T.CD4_Tcm.Tfh_like	5.72e-03	Nonsignificant	0.66	1.12	Other	102	214
543	T.CD8_Trm.homeostatic	5.65e-03	Nonsignificant	0.85	0.85	Other	42	5
544	FIB.neurolectin_mucosa.inflammatory	5.64e-03	Nonsignificant	0.60	0.96	Other	52	110
545	T.CD8_Tcm.NK_like	5.63e-03	Nonsignificant	0.38	1.28	Other	334	581
546	T.CD4_Tcm.migratory_cilium	5.55e-03	Nonsignificant	0.45	1.23	Other	5	10
547	EPI.colonocyte.goblet_interface	5.29e-03	Nonsignificant	—	0.60	Other	11	21
548	EPI.renal_principal_cell.intercalated_like	5.24e-03	Nonsignificant	0.47	1.39	Other	63	66
549	T.CD4_Tem.transitional_CM	5.13e-03	Nonsignificant	0.87	0.91	Other	31	20
550	FIB.adventitial.mechano_chemo_sensing	5.08e-03	Nonsignificant	0.98	0.85	Other	135	524
551	T.CD4_Tcm.effector_like	5.02e-03	Nonsignificant	0.85	1.02	Other	293	533
552	NK.cytokine_lung_immediate_early	4.92e-03	Nonsignificant	1.00	1.01	Other	424	274
553	T.CD4_Th17.baseline	4.72e-03	Nonsignificant	0.90	0.81	Other	51	5
554	EPI.renal_distal_tubule.stress	4.44e-03	Nonsignificant	—	0.00	Other	0	0
555	T.CD8_transitional.effector_primed	4.37e-03	Nonsignificant	0.65	1.04	Other	435	151
556	CHOND.activated_fibro_like	4.25e-03	Nonsignificant	0.83	0.86	Other	531	188
557	T.CD8_transitional.stress	4.22e-03	Nonsignificant	—	0.67	Other	24	34
558	CHOND.articular_collagen	4.17e-03	Nonsignificant	0.83	1.01	Other	551	266
559	EC.capillary.migratory	4.01e-03	Nonsignificant	0.99	0.88	Other	181	509
560	T.CD4_Tcm.APC_mimicry	3.99e-03	Nonsignificant	0.85	0.99	Other	54	43
561	T.CD8_Tem.baseline	3.87e-03	Nonsignificant	0.25	1.07	Other	458	356
562	HEP.acute_phase.inflammatory	3.86e-03	Nonsignificant	1.00	0.40	Other	382	649
563	T.CD4_Tcm.imprinted_splicing	3.82e-03	Nonsignificant	0.85	0.99	Other	6	17
564	EPI.salivary_myoepithelial.activated	3.78e-03	Nonsignificant	0.77	0.91	Other	85	281
565	T.gamma_delta.central_memory	3.73e-03	Nonsignificant	0.95	0.86	Other	460	919
566	FIB.neurolectin_mucosa.remodeling_repair	3.66e-03	Nonsignificant	—	0.00	Other	4	2
567	T.CD4_cytotoxic.precursor	3.60e-03	Nonsignificant	0.29	1.22	Other	156	67
568	MESO.antiviral	3.49e-03	Nonsignificant	—	0.32	Other	3	8
569	T.CD4_Tcm.Th2_like	3.39e-03	Nonsignificant	0.85	0.91	Other	23	55
570	T.CD4_Tcm.synapse_dynamics	3.38e-03	Nonsignificant	0.85	1.05	Other	15	10
571	FIB.adventitial.complement_angiocrine	3.31e-03	Nonsignificant	0.98	0.85	Other	153	684
572	EPI.colonocyte.secretory_boost	3.29e-03	Nonsignificant	1.00	0.80	Other	98	91
573	T.CD8_Trm.cytotoxic	3.24e-03	Nonsignificant	0.85	0.91	Other	165	85
574	EPI.salivary_myoepithelial.baseline	3.23e-03	Nonsignificant	0.77	0.84	Other	42	141
575	EPI.renal_proximal_tubule.detox_antioxidant	3.03e-03	Nonsignificant	0.05	1.96	Other	394	77
576	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	2.99e-03	Nonsignificant	0.62	0.90	Other	33	34
577	EPI.thymic_medullary.proliferative_APC	2.97e-03	Nonsignificant	—	0.16	Other	0	0
578	T.CD8_Tcm.helper_like	2.93e-03	Nonsignificant	0.73	0.91	Other	81	159
579	EPI.skin_sweat_duct_keratinocyte.repair	2.87e-03	Nonsignificant	—	0.00	Other	0	0
580	EPI.lung_club_secretory.inflammatory	2.85e-03	Nonsignificant	—	0.37	Other	0	0
581	T.CD4_Treg.central_naive_like	2.75e-03	Nonsignificant	1.00	0.19	Other	333	45
582	EPI.renal_immature_ureteric_bud.osmoprotective	2.72e-03	Nonsignificant	0.70	1.02	Other	126	44
583	T.CD4_Tcm.DC_interact	2.53e-03	Nonsignificant	0.85	0.97	Other	72	32
584	EC.heart_remodeling.translation_boost	2.48e-03	Nonsignificant	—	0.53	Other	0	0
585	MESO.baseline	2.41e-03	Nonsignificant	0.88	0.61	Other	0	6
586	EPI.colonocyte.junction_remodeling	2.41e-03	Nonsignificant	1.00	0.54	Other	218	305
587	EPI.renal_proximal_tubule.onecarbon_peroxisome	2.38e-03	Nonsignificant	0.97	0.07	Other	58	89
588	MAC.resident_repair.lipid_phagocytic	2.37e-03	Nonsignificant	1.00	0.82	Other	228	604
589	EC.heart_remodeling.perivascular	2.33e-03	Nonsignificant	0.44	1.12	Other	124	408
590	MESO.activated_stress	2.22e-03	Nonsignificant	—	0.00	Other	0	0
591	T.CD8_transitional.APC_like	2.20e-03	Nonsignificant	0.88	0.92	Other	205	62
592	T.CD8_Tcm.effector_bias	2.17e-03	Nonsignificant	0.54	1.09	Other	199	329
593	FIB.adventitial.PI16_matrix	2.14e-03	Nonsignificant	0.98	0.73	Other	70	90
594	EPI.thymic_medullary.hormone_xeno_barrier	2.07e-03	Nonsignificant	—	0.00	Other	0	8
595	B.germinal_center.DZ_M_phase	2.02e-03	Nonsignificant	—	1.47	Other	0	0
596	EC.heart_remodeling.activated_acute	1.95e-03	Nonsignificant	0.17	1.40	Other	102	186
597	EC.heart_remodeling.remodeling_stalk	1.91e-03	Nonsignificant	0.84	1.00	Other	33	111
598	EPI.renal_intercalated_cell_type_A.PC_transitional	1.86e-03	Nonsignificant	—	0.00	Other	203	407
599	EPI.colonocyte.crypt_progenitor	1.86e-03	Nonsignificant	1.00	0.33	Other	115	265
600	PERI.cardiac_skeletal	1.77e-03	Nonsignificant	1.00	0.52	Other	313	630
601	T.CD4_Tcm.retro_ZNF117	1.74e-03	Nonsignificant	0.85	0.86	Other	5	9
602	MESO.activated_migratory	1.67e-03	Nonsignificant	—	0.00	Other	0	0
603	EPI.renal_principal_cell.canonical_vasopressin	1.65e-03	Nonsignificant	0.62	1.27	Other	2	0
604	ASPC.activated	1.63e-03	Nonsignificant	0.95	0.84	Other	164	162
605	FIB.interstitial.mesenchymal_APC	1.60e-03	Nonsignificant	1.00	0.59	Other	81	33
606	T.CD4_Tem.cytotoxic_effector	1.56e-03	Nonsignificant	1.00	0.47	Other	225	398
607	T.CD4_Tcm.secretory	1.55e-03	Nonsignificant	0.85	0.87	Other	20	11
608	B.memory.pDC_imprint	1.54e-03	Nonsignificant	1.00	0.60	Other	157	103
609	ADIPO.hypoxia_remodelling	1.49e-03	Nonsignificant	—	0.00	Other	29	105
610	EPI.salivary_myoepithelial.junctional_transport	1.48e-03	Nonsignificant	0.77	0.97	Other	66	121
611	ADIPO.immature	1.47e-03	Nonsignificant	—	0.00	Other	24	40
612	MAC.resident_repair.ECM_stromal_crosstalk	1.44e-03	Nonsignificant	1.00	0.71	Other	95	158
613	EPI.skin_hair_follicle_bulge.anagen_growth	1.41e-03	Nonsignificant	—	0.00	Other	0	0
614	NK.adaptive_HLAE_tuned	1.39e-03	Nonsignificant	1.00	1.03	Other	1,124	189
615	T.CD8_Tcm.baseline	1.35e-03	Nonsignificant	0.73	0.87	Other	90	89
616	T.CD4_Tcm.RNA_control	1.24e-03	Nonsignificant	0.98	0.75	Other	96	4
617	EC.heart_remodeling.remodeling_secretory	1.21e-03	Nonsignificant	0.84	1.01	Other	605	1,341
618	T.CD4_naive.gut_prone	1.19e-03	Nonsignificant	1.00	0.14	Other	35	70
619	FIB.barrier_secretory.remodeling	1.15e-03	Nonsignificant	—	0.00	Other	0	0
620	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.10e-03	Nonsignificant	—	0.00	Other	39	82
621	THYMO.DP_early	1.07e-03	Nonsignificant	1.00	0.54	Other	326	313
622	EPI.renal_thick_ascending_limb.salt_sensing	1.04e-03	Nonsignificant	1.00	0.03	Other	73	103
623	T.MAIT.migratory	1.04e-03	Nonsignificant	0.62	1.20	Other	10	1
624	EPI.skin_appendage_keratinocyte.transit_amplifying	1.00e-03	Nonsignificant	—	0.00	Other	109	358
625	NK.cytokine_tissue_resident	9.47e-04	Nonsignificant	1.00	1.00	Other	74	82
626	EPI.renal_immature_ureteric_bud.defense_secretory	8.61e-04	Nonsignificant	0.59	1.17	Other	45	76
627	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	8.55e-04	Nonsignificant	—	0.00	Other	0	0
628	FIB.barrier_purinergic.stress_GF_binding	8.16e-04	Nonsignificant	—	0.00	Other	0	0
629	NK.adaptive_immature_precursor	6.24e-04	Nonsignificant	1.00	1.01	Other	358	111
630	B.germinal_center.LZ_selection	5.65e-04	Nonsignificant	—	0.21	Other	0	0
631	NK.cytokine_axis_baseline	5.41e-04	Nonsignificant	1.00	0.94	Other	1,172	116
632	FIB.interstitial.stress_secretory	5.23e-04	Nonsignificant	1.00	0.45	Other	92	56
633	EPI.renal_principal_cell.activated_acute	5.17e-04	Nonsignificant	0.90	0.94	Other	29	59
634	EPI.thymic_medullary.stress_APC	4.93e-04	Nonsignificant	1.00	0.06	Other	2	4
635	EPI.skin_hair_follicle_companion.activated_migratory	4.77e-04	Nonsignificant	—	0.00	Other	0	0
636	T.CD4_cytotoxic.NK_adapted	4.60e-04	Nonsignificant	0.56	1.12	Other	82	33
637	EPI.renal_distal_tubule.repair	3.75e-04	Nonsignificant	—	0.04	Other	34	102
638	FIB.adventitial.activated_remodelling	3.66e-04	Nonsignificant	—	0.00	Other	141	319
639	B.germinal_center.DZ_S_phase	3.47e-04	Nonsignificant	—	0.18	Other	0	0
640	T.MAIT.MAPK_brake	3.15e-04	Nonsignificant	0.62	1.11	Other	44	66
641	EPI.lung_club_secretory.ciliogenesis_primed	3.13e-04	Nonsignificant	—	0.00	Other	0	0
642	NK.cytokine_quiescent	3.04e-04	Nonsignificant	1.00	0.96	Other	623	1,062
643	T.CD8_Tem.TEMRA	2.91e-04	Nonsignificant	0.88	1.02	Other	920	1,088
644	T.CD4_cytotoxic.activated	2.76e-04	Nonsignificant	0.77	1.00	Other	3	1
645	EC.heart_remodeling.angiocrine	2.70e-04	Nonsignificant	1.00	0.65	Other	182	525
646	MAC.LAM.lipid_phagocytosis	2.68e-04	Nonsignificant	1.00	0.86	Other	369	328
647	EPI.renal_distal_tubule.ciliated_remodelling	2.66e-04	Nonsignificant	—	0.00	Other	0	0
648	T.MAIT.cytotoxic	2.59e-04	Nonsignificant	0.62	1.11	Other	52	15
649	NK.cytokine_biosynthetic_primed	2.41e-04	Nonsignificant	1.00	0.95	Other	360	21
650	ASPC.mesothelial_like	2.26e-04	Nonsignificant	0.95	0.48	Other	143	486
651	ILC2.quiescent	2.16e-04	Nonsignificant	—	0.00	Other	0	0
652	ASPC.signal_integrator	2.11e-04	Nonsignificant	—	0.00	Other	0	0
653	EPI.renal_principal_cell.inflammatory	2.08e-04	Nonsignificant	0.90	0.73	Other	74	157
654	T.CD8_Tem.stress_adapted	2.06e-04	Nonsignificant	0.90	0.94	Other	607	520
655	T.CD8_Tem.signaling_turnover	1.80e-04	Nonsignificant	0.88	1.05	Other	425	683
656	T.CD4_cytotoxic.baseline	1.43e-04	Nonsignificant	0.77	1.01	Other	0	0
657	NK.cytokine_repair_primed	1.42e-04	Nonsignificant	1.00	1.01	Other	266	11
658	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.36e-04	Nonsignificant	—	0.00	Other	0	0
659	NK.adaptive_axis_baseline	1.20e-04	Nonsignificant	1.00	0.99	Other	1,008	153
660	THYMO.SP_CD8_naive	1.16e-04	Nonsignificant	1.00	0.18	Other	297	177
661	NK.adaptive_classII_inhibitory	1.11e-04	Nonsignificant	1.00	0.90	Other	880	154
662	EPI.renal_distal_tubule.ion_transport	9.60e-05	Nonsignificant	—	0.00	Other	0	0
663	EC.heart_remodeling.capillary_metabolic	9.60e-05	Nonsignificant	1.00	0.64	Other	54	414
664	THYMO.CD8aa_IELp	8.33e-05	Nonsignificant	—	0.00	Other	1	7
665	EPI.renal_principal_cell.injury_repair	7.91e-05	Nonsignificant	0.90	0.57	Other	26	9
666	T.CD8_Tem.early_helper_like	7.48e-05	Nonsignificant	0.90	0.96	Other	445	755
667	T.CD4_cytotoxic.terminal_effector	6.90e-05	Nonsignificant	0.93	0.84	Other	286	21
668	MAC.LAM.antimicrobial	6.17e-05	Nonsignificant	1.00	0.64	Other	389	93
669	NK.cytokine_vascular_patrolling	5.75e-05	Nonsignificant	1.00	0.90	Other	863	94
670	EPI.skin_sweat_duct_keratinocyte.proliferative_S	5.68e-05	Nonsignificant	—	0.00	Other	0	0
671	T.MAIT.quiescent	5.38e-05	Nonsignificant	0.99	0.57	Other	100	5
672	NK.cytokine_tissue_activation	4.88e-05	Nonsignificant	1.00	0.90	Other	267	450
673	T.MAIT.stress	3.96e-05	Nonsignificant	—	0.00	Other	0	0
674	B.germinal_center.LZ_survival	3.64e-05	Nonsignificant	—	0.00	Other	0	0
675	EPI.lung_multiciliated.baseline	3.52e-05	Nonsignificant	—	0.51	Other	0	7
676	NK.adaptive_adipose_stress	3.09e-05	Nonsignificant	1.00	0.84	Other	374	39
677	NK.adaptive_terminal_cytotoxic	2.83e-05	Nonsignificant	1.00	0.80	Other	485	802
678	B.germinal_center.LZ_memory_precursor	2.40e-05	Nonsignificant	—	0.00	Other	0	0
679	T.MAIT.vesicle	1.85e-05	Nonsignificant	0.99	0.27	Other	37	65
680	T.CD8_Tem.motility_primed	1.09e-05	Nonsignificant	0.90	0.91	Other	269	4
681	EPI.thymic_cortical.secretory_remodeling	9.15e-06	Nonsignificant	—	0.41	Other	4	1
682	NK.adaptive_biosynthetic_primed	8.46e-06	Nonsignificant	1.00	0.87	Other	244	405
683	MAC.LAM.perivascular_angiocrine	5.46e-06	Nonsignificant	—	0.00	Other	53	138
684	EPI.lung_multiciliated.stress	3.82e-06	Nonsignificant	—	0.00	Other	67	165
685	EPI.salivary_mucous_acinar.baseline	2.69e-06	Nonsignificant	—	—	Other	394	683
686	EPI.lung_club_secretory.ciliogenesis_axoneme	3.40e-07	Nonsignificant	—	0.00	Other	0	0
687	EPI.thymic_cortical.Notch_interface	7.95e-09	Nonsignificant	—	0.49	Other	82	137
688	EPI.thymic_cortical.baseline	5.21e-09	Nonsignificant	0.79	0.48	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

25 unique genes. Showing 1–25. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
TRMT10A	02-Medium	0.68	12.41	G1	C2	—	—	5 cells — complete matches	51	211
MTTP	02-Medium	0.66	12.85	G1	C2	EPI.ileal_enterocyte_crypt.villus_transition (L2)	—	19 cells — complete matches	53	229
ADH1C	02-Medium	0.56	9.72	G1	C2	EPI.bile_duct_cholangiocyte.secretory_mucin (L2), EPI.ileal_bile_transport.detox_transcytosis (L2), EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2), EPI.salivary_intercalated_defense.basal_EMT (L2), EPI.salivary_myoepithelial.baseline (L2), EPI.tracheal_suprabasal.secretory_immune (L2)	EPI.bile_duct_cholangiocyte (Tier: relevant) EPI.tracheal_suprabasal (Tier: relevant) EPI.bile_duct_cholangiocyte.secretory_mucin (Tier: relevant) EPI.tracheal_suprabasal.secretory_immune (Tier: relevant)	54 cells — complete matches	133	303
DAPP1	02-Medium	0.53	12.23	G2	C2	—	haematopoietic_progenitor_cell (Tier: relevant) HPC.haematopoietic_progenitor_cell (Tier: relevant) EPI.esophageal_basal.junctional_barrier (Tier: relevant) MAC.MDM.APC_dendritic (Tier: relevant)	79 cells — complete matches	35	104
ADH1B	02-Medium	0.53	10.02	G1	C2	FIB.neurolectin_mucosa.remodeling_repair (L2), FIB.suburothelial.homeostasis_matrix (L2), HEP.periportal_metabolic.xenobiotic_detox (L2)	—	73 cells — complete matches	99	251
C4orf54	02-Medium	0.52	14.33	G1	C2	—	—	—	55	227
ENSG00000299569	02-Medium	0.49	8.34	G2	C1	—	—	—	1	2
H2AZ1	02-Medium	0.49	10.91	G2	C2	—	—	—	1	2
LINC01122	02-Medium	0.48	7.64	G1	C2	—	—	28 cells — complete matches	4	5
ENSG00000299292	02-Medium	0.48	9.94	G1	C2	—	—	—	130	304
ADH1A	02-Medium	0.48	8.45	G1	C2	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2)	EPI.bile_duct_cholangiocyte (Tier: relevant) EPI.bile_duct_cholangiocyte.secretory_mucin (Tier: relevant)	15 cells — complete matches	131	299
ENSG00000248676	02-Medium	0.47	10.93	G1	C2	—	—	—	51	211
CENPW	02-Medium	0.46	4.38	G1	C2	DC.cDC1.proliferative (L2), EPI.ileal_enterocyte_crypt.proliferative_G2M (L2), IPSC.proliferative (L2), THYMO.proliferative_S (L2)	EPI.skin_keratinocyte_proliferating.early_spinous_transition (Tier: specific) EPI.skin_keratinocyte_proliferating (Tier: relevant) DC.cDC2.proliferative (Tier: relevant) EPI.ectocervical_granular.proliferative_basal (Tier: relevant) EPI.skin_keratinocyte_basal.transit_amplifying (Tier: relevant)	46 cells — complete matches	17	39
ENSG00000299279	02-Medium	0.45	8.52	G1	C2	—	—	—	134	304
ENSG00000303547	02-Medium	0.43	11.41	G2	C2	—	—	—	2	4
ADH6	02-Medium	0.42	7.00	G1	C2	EPI.colonic_enteroendocrine.enterochromaffin_serotonin (L2)	EPI.colonic_tuft.homeostatic (Tier: relevant)	14 cells — complete matches	130	298
H2AZ1-DT	02-Medium	0.41	7.94	G2	C2	—	—	—	1	2
ADH7	02-Medium	0.40	9.79	G1	C2	—	EPI.esophageal_suprabasal (Tier: specific) EPI.tracheal_basal (Tier: relevant) EPI.tracheal_suprabasal (Tier: relevant) EPI.skin_keratinocyte_basal.transit_amplifying (Tier: relevant) EPI.tracheal_suprabasal.secretory_immune (Tier: relevant)	19 cells — complete matches	122	279
ENSG00000293110	02-Medium	0.40	2.89	G1	C2	—	—	—	10	23
LAMTOR3	02-Medium	0.39	7.86	G2	C2	—	—	MAC.proliferating.DNA_replication (L2), T.CD4_Tcm.tissue_homing (L2)	1	2
ENSG00000246090	02-Medium	0.39	4.21	G1	C2	—	—	—	103	272
ADH4	02-Medium	0.33	5.63	G1	C2	HEP.acute_phase.complement_metabolic (L2)	—	24 cells — complete matches	132	294
ENSG00000306670	02-Medium	0.23	3.62	G2	C2	—	—	—	0	0
ENSG00000286716	02-Medium	0.21	3.57	G2	C2	—	—	—	0	0
ENSG00000254044	02-Medium	0.19	3.75	G2	C2	—	—	—	3	4

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.