Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000050 · All tissues

Alcohol dependence: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Alcohol use disorder

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	25.10	Significant	7.74e-48	1.23	Relevant	0	0
2	platelet	20.80	Significant	—	1.53	Relevant	85	104
3	neuron	18.27	Significant	3.39e-05	1.12	Specific	330	1,328
4	oligodendrocyte_precursor_cell	16.13	Significant	2.30e-03	1.19	Specific	461	1,454
5	monocyte	12.50	Significant	1.24e-46	1.17	Specific	2,176	3,871
6	haematopoietic_progenitor_cell	9.94	Significant	1.00	1.01	Relevant	262	502
7	dendritic_cell	6.23	Significant	1.00	0.95	Other	496	724
8	oligodendrocyte	5.40	Nominal	4.99e-05	1.07	Other	385	1,507
9	granulosa_cell	4.83	Nominal	1.00	0.91	Other	293	670
10	astrocyte	2.40	Nonsignificant	1.00	0.92	Other	256	1,203
11	cardiomyocyte	1.51	Nonsignificant	1.00	0.93	Other	533	2,045
12	epithelial_cell	1.46	Nonsignificant	1.00	0.89	Other	24	47
13	melanocyte	1.41	Nonsignificant	1.00	0.83	Other	97	309
14	thymocyte	1.30	Nonsignificant	1.00	0.86	Other	168	512
15	macrophage	1.28	Nonsignificant	1.00	0.86	Other	813	1,732
16	schwann_cell	1.28	Nonsignificant	1.00	0.90	Other	10	57
17	skeletal_muscle_cell	0.68	Nonsignificant	1.00	0.92	Other	944	2,600
18	granulocyte	0.65	Nonsignificant	1.00	0.82	Other	5	6
19	innate_lymphoid_cell_2	0.41	Nonsignificant	1.00	0.85	Other	3	8
20	hepatocyte	0.24	Nonsignificant	1.00	0.77	Other	1,515	3,822
21	plasma_cell	0.17	Nonsignificant	1.00	0.74	Other	17	24
22	smooth_muscle_cell	0.13	Nonsignificant	1.00	0.71	Other	27	139
23	microglia	0.05	Nonsignificant	1.00	0.66	Other	61	129
24	endothelial_cell	0.04	Nonsignificant	1.00	0.66	Other	373	974
25	B_cell	0.02	Nonsignificant	1.00	0.61	Other	356	694
26	muscle_stem_cell	0.02	Nonsignificant	1.00	0.62	Other	7	27
27	fibroblast	0.02	Nonsignificant	1.00	0.62	Other	184	826
28	T_cell	0.02	Nonsignificant	1.00	0.51	Other	470	959
29	pericyte	0.01	Nonsignificant	1.00	0.59	Other	128	517
30	adipose_stem_and_progenitor_cell	0.01	Nonsignificant	1.00	0.53	Other	327	954
31	natural_killer_cell	0.01	Nonsignificant	1.00	0.68	Other	1,204	2,052
32	mesothelial_cell	7.17e-03	Nonsignificant	1.00	0.52	Other	6	36
33	chondrocyte	3.97e-03	Nonsignificant	1.00	0.47	Other	548	1,069
34	adipocyte	3.59e-03	Nonsignificant	1.00	0.48	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	IPSC.induced_pluripotent_stem_cell	25.10	Significant	—	—	Relevant	0	0
2	NEU.INH_PVALB	24.41	Significant	0.06	1.54	—	193	183
3	NEU.EXC_IT	23.33	Significant	1.20e-05	1.96	—	411	192
4	NEU.EXC_SYT2	22.84	Significant	—	0.66	—	40	77
5	PLAT.platelet	20.80	Significant	—	0.00	Relevant	38	53
6	DC.pDC	19.11	Significant	6.24e-05	1.67	Specific	496	1,028
7	OPC.oligodendrocyte_precursor_cell	16.13	Significant	—	—	Specific	413	1,269
8	NEU.EXC_CT	14.42	Significant	1.00	0.58	—	362	384
9	EPI.intrahepatic_cholangiocyte_transport	13.71	Significant	—	2.35	Relevant	12	42
10	MONO.CD14	13.41	Significant	3.18e-28	2.74	Specific	2,294	4,139
11	NEU.EXC_NTNG1	12.62	Significant	—	0.00	—	0	0
12	EPI.hepatic_ductular_cholangiocyte	10.26	Significant	0.04	1.32	Relevant	83	243
13	HPC.haematopoietic_progenitor_cell	9.94	Significant	—	—	Relevant	211	370
14	EPI.pancreatic_ductal_bicarbonate	8.61	Significant	2.88e-06	1.37	Specific	131	548
15	MAC.alveolar	7.89	Significant	9.63e-06	1.30	Specific	1,432	3,122
16	MONO.CD16	7.80	Significant	1.00	0.44	—	1,304	1,835
17	NEU.INH_VIP	6.80	Significant	1.00	0.19	—	241	366
18	OLG.oligodendrocyte	5.40	Nominal	—	—	Other	384	1,397
19	EPI.esophageal_suprabasal	5.28	Nominal	0.02	1.29	Other	158	404
20	GRNLSA.granulosa_cell	4.83	Nominal	—	—	Other	257	0
21	EPI.bile_duct_cholangiocyte	4.23	Nominal	1.00	1.02	Other	37	60
22	EPI.pancreatic_islet	4.22	Nominal	0.57	1.22	Other	52	132
23	DC.cDC2	3.91	Nominal	1.00	0.33	Other	1,189	1,793
24	EPI.skin_keratinocyte_proliferating	3.86	Nominal	1.00	1.14	Other	47	76
25	MAC.kupffer	3.77	Nominal	0.66	1.09	Other	189	530
26	EPI.pancreatic_ductal_perivascular	3.72	Nominal	0.89	1.15	Other	4	30
27	EPI.endocervical_secretory	2.97	Nonsignificant	—	0.95	Other	0	0
28	EPI.skin_interfollicular_spinous	2.78	Nonsignificant	0.89	1.09	Other	260	563
29	EPI.intrahepatic_cholangiocyte_defense	2.63	Nonsignificant	—	0.92	Other	8	13
30	EPI.pancreatic_acinar	2.61	Nonsignificant	0.57	1.08	Other	429	1,475
31	EPI.cervical_suprabasal	2.56	Nonsignificant	—	0.81	Other	14	50
32	EPI.colonic_tuft	2.55	Nonsignificant	—	0.86	Other	7	24
33	EPI.salivary_duct_excretory	2.52	Nonsignificant	1.00	1.06	Other	85	180
34	ASTRO.astrocyte	2.40	Nonsignificant	—	—	Other	228	1,111
35	DC.cDC1	2.36	Nonsignificant	1.00	0.51	Other	55	112
36	EPI.pancreatic_ductal_progenitor	2.35	Nonsignificant	0.89	1.10	Other	234	873
37	EPI.ectocervical_granular	1.94	Nonsignificant	—	0.43	Other	11	23
38	EPI.thymic_cortical	1.92	Nonsignificant	1.00	1.11	Other	442	824
39	MAC.MDM	1.88	Nonsignificant	0.49	1.08	Other	623	986
40	EPI.colonic_enteroendocrine	1.79	Nonsignificant	—	0.55	Other	1	1
41	NEU.INH_LAMP5	1.65	Nonsignificant	1.00	0.00	Other	263	532
42	SKM.type_1_slow	1.52	Nonsignificant	8.97e-19	1.65	Other	923	2,478
43	EPI.esophageal_basal	1.52	Nonsignificant	1.00	0.98	Other	4	10
44	CM.cardiomyocyte	1.51	Nonsignificant	—	—	Other	524	2,032
45	EPI.tracheal_suprabasal	1.43	Nonsignificant	1.00	0.94	Other	29	56
46	MEL.melanocyte	1.41	Nonsignificant	—	—	Other	79	242
47	EPI.tracheal_basal	1.36	Nonsignificant	1.00	0.97	Other	398	1,120
48	EPI.skin_keratinocyte_basal	1.34	Nonsignificant	—	0.54	Other	13	26
49	THYMO.thymocyte	1.30	Nonsignificant	—	—	Other	163	495
50	SCHWN.schwann_cell	1.28	Nonsignificant	—	—	Other	7	33
51	MAC.proliferating	1.22	Nonsignificant	1.00	0.93	Other	87	253
52	EPI.extrahepatic_cholangiocyte	1.09	Nonsignificant	—	0.43	Other	37	71
53	GRANU.neutrophil	1.05	Nonsignificant	0.01	2.03	Other	1,235	2,649
54	EPI.salivary_intercalated_defense	0.81	Nonsignificant	1.00	0.83	Other	81	161
55	EPI.skin_follicular_keratinizing	0.80	Nonsignificant	1.00	0.74	Other	30	81
56	B.germinal_center	0.61	Nonsignificant	0.01	1.37	Other	233	655
57	EPI.renal_thick_ascending_limb	0.60	Nonsignificant	1.00	0.78	Other	453	1,153
58	EPI.salivary_serous_acinar	0.58	Nonsignificant	1.00	0.83	Other	233	531
59	HEP.periportal_metabolic	0.54	Nonsignificant	1.63e-15	1.27	Other	1,750	4,427
60	EPI.renal_proximal_tubule	0.53	Nonsignificant	1.00	0.80	Other	525	806
61	MAC.resident_iron	0.52	Nonsignificant	1.00	0.92	Other	16	21
62	PC.IgG_systemic	0.52	Nonsignificant	4.85e-03	1.35	Other	41	60
63	EC.lymphatic	0.49	Nonsignificant	0.04	1.17	Other	630	998
64	EPI.tracheal_submucosal_gland	0.43	Nonsignificant	—	0.20	Other	0	0
65	FIB.hepatic_stellate_cell	0.43	Nonsignificant	—	2.25	Other	64	252
66	GRANU.MAST	0.41	Nonsignificant	1.00	0.00	Other	5	6
67	ILC2.innate_lymphoid_cell_2	0.41	Nonsignificant	—	—	Other	2	0
68	EPI.alveolar_type_1	0.38	Nonsignificant	1.00	0.73	Other	26	101
69	EPI.ileal_bile_transport	0.36	Nonsignificant	1.00	0.76	Other	61	93
70	DC.mig	0.29	Nonsignificant	—	0.00	Other	89	156
71	MAC.resident_repair	0.21	Nonsignificant	1.00	0.72	Other	796	1,426
72	MAC.LAM	0.21	Nonsignificant	1.00	0.74	Other	914	2,064
73	MAC.resident_cardiac	0.18	Nonsignificant	1.00	0.67	Other	485	1,074
74	FIB.transitioning	0.16	Nonsignificant	0.48	1.17	Other	172	497
75	EPI.renal_intercalated_cell_type_A	0.15	Nonsignificant	1.00	0.60	Other	67	142
76	B.age_associated	0.14	Nonsignificant	0.20	1.22	Other	207	350
77	FIB.tracheal_subepithelial	0.13	Nonsignificant	—	1.61	Other	0	0
78	SMC.smooth_muscle_cell	0.13	Nonsignificant	—	—	Other	20	101
79	PC.IgA_muocsal	0.12	Nonsignificant	1.00	0.28	Other	18	31
80	HEP.pericentral_lipoprotein	0.12	Nonsignificant	—	0.69	Other	0	0
81	FIB.reticular	0.12	Nonsignificant	0.48	1.13	Other	19	87
82	FIB.barrier_secretory	0.12	Nonsignificant	0.48	1.25	Other	81	228
83	EC.liver_sinusoidal	0.11	Nonsignificant	1.00	1.05	Other	1,083	1,925
84	T.CD4_Tfh	0.10	Nonsignificant	0.70	1.08	Other	47	45
85	MAC.microglia_like	0.08	Nonsignificant	1.00	0.63	Other	124	179
86	EPI.gastric_foveolar	0.08	Nonsignificant	—	0.00	Other	0	0
87	EPI.skin_hair_follicle_companion	0.07	Nonsignificant	—	0.00	Other	8	12
88	T.CD4_transitional	0.07	Nonsignificant	0.70	1.08	Other	48	110
89	HEP.acute_phase	0.06	Nonsignificant	1.00	0.72	Other	1,441	3,641
90	EPI.skin_keratinocyte_progenitor	0.06	Nonsignificant	—	0.00	Other	0	3
91	EPI.ileal_enterocyte_absorptive	0.06	Nonsignificant	1.00	0.58	Other	118	338
92	HEP.canalicular_transport	0.05	Nonsignificant	1.00	0.66	Other	1,290	3,434
93	SKM.type_2_fast	0.05	Nonsignificant	0.01	1.19	Other	972	2,639
94	MG.microglia	0.05	Nonsignificant	—	—	Other	49	0
95	EPI.skin_sweat_duct_keratinocyte	0.04	Nonsignificant	1.00	0.67	Other	146	301
96	FIB.perivascular_interface	0.04	Nonsignificant	0.48	1.17	Other	0	0
97	EPI.ileal_enterocyte_crypt	0.04	Nonsignificant	1.00	0.48	Other	67	113
98	T.CD4_naive	0.03	Nonsignificant	0.03	1.06	Other	399	866
99	FIB.skin_neurosecretory	0.03	Nonsignificant	—	1.21	Other	0	0
100	T.CD4_Tem	0.03	Nonsignificant	0.90	1.00	Other	365	697
101	T.CD4_Trm	0.03	Nonsignificant	0.90	1.01	Other	176	363
102	EPI.lung_club_secretory	0.03	Nonsignificant	1.00	0.55	Other	5	14
103	FIB.suburothelial	0.03	Nonsignificant	0.71	1.06	Other	122	432
104	EC.capillary	0.02	Nonsignificant	1.00	0.93	Other	514	1,635
105	MUSC.muscle_stem_cell	0.02	Nonsignificant	—	—	Other	4	18
106	FIB.skin_sheath	0.02	Nonsignificant	0.80	1.02	Other	49	118
107	EC.arterial	0.02	Nonsignificant	1.00	0.92	Other	356	885
108	FIB.lung_alveolar	0.02	Nonsignificant	—	0.88	Other	6	15
109	T.CD4_Th17	0.02	Nonsignificant	0.86	1.04	Other	421	794
110	FIB.barrier_purinergic	0.01	Nonsignificant	—	0.84	Other	1	3
111	EPI.renal_intercalated_cell_type_B	0.01	Nonsignificant	—	0.00	Other	6	7
112	EPI.thymic_medullary	0.01	Nonsignificant	1.00	0.48	Other	26	133
113	B.memory	0.01	Nonsignificant	1.00	0.90	Other	442	882
114	EC.heart_remodeling	0.01	Nonsignificant	1.00	0.95	Other	569	1,594
115	PERI.pericyte	0.01	Nonsignificant	—	—	Other	117	0
116	EPI.skin_appendage_keratinocyte	0.01	Nonsignificant	1.00	0.43	Other	87	222
117	T.CD8_Trm	0.01	Nonsignificant	1.00	0.95	Other	211	346
118	ASPC.adipose_stem_and_progenitor_cell	0.01	Nonsignificant	—	—	Other	324	930
119	NK.natural_killer_cell	0.01	Nonsignificant	—	—	Other	1,204	2,045
120	EC.venous	0.01	Nonsignificant	1.00	0.83	Other	516	1,387
121	FIB.adventitial	9.83e-03	Nonsignificant	1.00	0.91	Other	268	1,447
122	T.CD8_transitional	9.75e-03	Nonsignificant	1.00	0.95	Other	497	932
123	EPI.lung_multiciliated	9.38e-03	Nonsignificant	1.00	0.56	Other	16	49
124	B.naive	9.21e-03	Nonsignificant	1.00	0.78	Other	307	595
125	EPI.pancreatic_ductal_mucinous	8.18e-03	Nonsignificant	1.00	0.55	Other	219	430
126	T.CD4_cytotoxic	8.02e-03	Nonsignificant	0.72	1.06	Other	855	1,493
127	T.CD4_Treg	7.48e-03	Nonsignificant	1.00	0.86	Other	244	511
128	MESO.mesothelial_cell	7.17e-03	Nonsignificant	—	—	Other	2	18
129	T.CD8_Tem	7.05e-03	Nonsignificant	0.70	1.05	Other	1,083	1,857
130	EPI.colonocyte	6.47e-03	Nonsignificant	1.00	0.33	Other	294	815
131	FIB.neurolectin_mucosa	5.92e-03	Nonsignificant	1.00	0.88	Other	133	394
132	FIB.skin_tenogenic	5.91e-03	Nonsignificant	—	0.63	Other	108	227
133	EPI.skin_hair_follicle_bulge	5.15e-03	Nonsignificant	1.00	0.34	Other	51	178
134	EPI.renal_distal_tubule	4.62e-03	Nonsignificant	1.00	0.35	Other	133	361
135	T.MAIT	4.44e-03	Nonsignificant	1.00	0.85	Other	469	855
136	T.CD8_Tcm	4.33e-03	Nonsignificant	1.00	0.89	Other	460	926
137	FIB.interstitial	4.24e-03	Nonsignificant	1.00	0.70	Other	288	940
138	CHOND.chondrocyte	3.97e-03	Nonsignificant	—	—	Other	519	730
139	EPI.renal_immature_ureteric_bud	3.74e-03	Nonsignificant	1.00	0.29	Other	217	569
140	ADIPO.adipocyte	3.59e-03	Nonsignificant	—	—	Other	20	62
141	EPI.ileal_goblet	3.53e-03	Nonsignificant	1.00	0.33	Other	181	432
142	T.CD4_Tcm	3.22e-03	Nonsignificant	1.00	0.86	Other	494	988
143	T.CD8_naive	3.13e-03	Nonsignificant	1.00	0.87	Other	317	708
144	EPI.salivary_duct_ion_transport	2.56e-03	Nonsignificant	1.00	0.31	Other	5	11
145	T.CD4_Th2	2.38e-03	Nonsignificant	—	0.76	Other	1	2
146	EPI.alveolar_type_2	2.02e-03	Nonsignificant	1.00	0.43	Other	813	1,853
147	EPI.salivary_mucous_acinar	1.56e-03	Nonsignificant	1.00	0.21	Other	639	1,189
148	T.gamma_delta	1.53e-03	Nonsignificant	1.00	0.78	Other	588	1,078
149	FIB.skin_papillary	7.33e-04	Nonsignificant	—	0.01	Other	0	0
150	EPI.salivary_myoepithelial	6.08e-04	Nonsignificant	1.00	0.13	Other	191	714
151	EPI.skin_sebaceous_duct_luminal	4.86e-04	Nonsignificant	1.00	0.16	Other	100	249
152	EPI.renal_principal_cell	3.98e-04	Nonsignificant	1.00	0.11	Other	207	403

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HPC.MPP_activated	45.79	Significant	—	1.98	—	0	0
2	PLAT.megakaryocytic	42.31	Significant	—	0.97	—	0	0
3	IPSC.neural_primed	38.59	Significant	7.94e-07	2.13	—	0	0
4	NEU.EXC_IT.adhesion	38.17	Significant	6.62e-06	2.65	—	252	108
5	IPSC.mesenchymal_primed	37.73	Significant	1.10e-14	2.38	—	0	0
6	MONO.CD14.cord_tolerance	36.63	Significant	2.32e-25	3.40	—	864	753
7	IPSC.midbrain_primed	34.86	Significant	0.04	1.66	Relevant	0	0
8	NEU.INH_PVALB.neuromodulatory	31.16	Significant	—	0.90	—	0	0
9	NEU.INH_PVALB.serotonergic	31.05	Significant	—	1.06	—	0	0
10	NEU.EXC_IT.transitional	29.15	Significant	6.94e-03	2.09	—	237	142
11	IPSC.proliferative	28.27	Significant	1.16e-03	1.60	—	0	0
12	IPSC.stress	26.98	Significant	0.46	1.26	Relevant	0	0
13	NEU.INH_PVALB.fastspike	25.14	Significant	—	0.30	—	24	22
14	NEU.INH_PVALB.nuclear_reg	24.63	Significant	0.53	1.33	—	25	12
15	NEU.EXC_SYT2.synaptic	24.42	Significant	—	0.00	—	0	0
16	DC.pDC.baseline	24.23	Significant	0.65	1.08	Relevant	88	123
17	IPSC.stromal_primed	24.10	Significant	1.00	0.62	—	0	0
18	NEU.INH_PVALB.metabotropic	21.83	Significant	—	0.00	—	0	0
19	NEU.EXC_IT.guidance	21.80	Significant	0.99	0.85	—	274	63
20	IPSC.mesendo_primed	21.55	Significant	1.00	0.72	—	0	0
21	DC.pDC.immature_metabolic	20.65	Significant	0.46	1.40	Relevant	78	124
22	NEU.EXC_CT.Ca2_sensor	20.63	Significant	—	0.89	—	0	0
23	NEU.EXC_IT.callosal	20.57	Significant	0.99	0.53	—	286	119
24	NEU.EXC_SYT2.nuclear_reg	20.30	Significant	—	0.00	—	0	0
25	NEU.INH_PVALB.chandelier	20.09	Significant	0.95	0.21	—	19	16
26	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	19.80	Significant	—	0.73	—	0	0
27	IPSC.axial_identity_primed	18.54	Significant	1.00	0.38	—	0	0
28	NEU.EXC_IT.structural	17.75	Significant	0.99	0.19	—	171	41
29	IPSC.mesodermal_primed	16.83	Significant	1.00	0.32	—	0	0
30	EPI.pancreatic_ductal_bicarbonate.inflammatory	16.82	Significant	8.56e-04	2.36	Specific	14	32
31	OPC.homeostatic	16.46	Significant	0.28	1.64	—	394	160
32	OPC.proliferative_immune_interact	16.33	Significant	0.33	1.35	Relevant	180	373
33	OPC.premyelinating	15.64	Significant	0.84	0.52	—	185	12
34	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	15.24	Significant	—	1.34	Relevant	0	0
35	EPI.hepatic_ductular_cholangiocyte.polarity	15.23	Significant	—	1.22	—	0	0
36	IPSC.neuroendocrine_primed	15.21	Significant	—	0.00	—	0	0
37	NEU.EXC_NTNG1.nuclear_reg	15.20	Significant	—	0.67	—	0	0
38	NEU.EXC_IT.neuromodulated	14.99	Significant	0.99	0.12	—	176	116
39	EPI.hepatic_ductular_cholangiocyte.secretory_transport	14.64	Significant	—	1.16	—	0	0
40	NEU.EXC_CT.projector	14.20	Significant	0.34	1.24	—	87	26
41	NEU.EXC_CT.Ca2_signaling	14.11	Significant	—	0.13	—	68	17
42	MAC.alveolar.scavenging_endocytic	14.04	Significant	—	1.49	Specific	140	283
43	MONO.CD14.baseline	13.66	Significant	0.02	1.36	—	2,268	76
44	MONO.CD14.inflammatory	13.47	Significant	0.92	0.82	—	92	134
45	HPC.MEP	12.90	Significant	0.33	1.41	Relevant	599	1,195
46	MONO.CD14.remodeling	12.86	Significant	0.92	1.01	—	2,373	295
47	GRNLSA.proliferative_migratory	12.54	Significant	3.28e-04	1.73	Specific	248	292
48	MONO.CD14.platelet_bound	12.22	Significant	0.92	0.94	—	964	176
49	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	11.98	Significant	—	0.00	—	0	0
50	EPI.esophageal_suprabasal.proliferative_G2M	11.95	Significant	—	2.10	Relevant	0	0
51	NEU.EXC_CT.remodeling	11.75	Significant	—	0.00	—	23	1
52	DC.pDC.poised_migratory	11.66	Significant	0.94	0.36	Relevant	54	95
53	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	11.29	Significant	—	0.27	—	0	0
54	MONO.CD16.inflammatory	11.12	Significant	4.60e-03	1.71	—	1,640	168
55	GRNLSA.angiocrine_mechanosensory	10.67	Significant	—	0.97	Relevant	0	0
56	HPC.MPP_IEG	10.43	Significant	0.95	1.03	—	45	46
57	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	10.12	Significant	—	0.00	—	5	3
58	NEU.INH_VIP.matrix	9.85	Significant	—	1.15	—	24	77
59	MONO.CD16.baseline	9.70	Significant	0.08	1.61	—	50	1
60	NEU.EXC_NTNG1.synaptic	9.67	Significant	—	0.00	—	0	0
61	EPI.hepatic_ductular_cholangiocyte.ion_transport	9.42	Significant	—	0.00	Relevant	0	0
62	NEU.INH_VIP.cannabinoid	9.36	Significant	—	0.56	—	0	0
63	EPI.pancreatic_acinar.quiet_dedifferentiation	9.35	Significant	3.54e-03	1.48	Specific	142	171
64	NEU.INH_VIP.nuclear_reg	9.25	Significant	—	0.92	—	20	4
65	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	9.08	Significant	0.34	1.50	Relevant	40	191
66	EPI.hepatic_ductular_cholangiocyte.stress	9.06	Significant	—	0.00	—	0	0
67	MAC.alveolar.biosynthetic_sterol_heme	8.91	Significant	0.55	1.48	—	347	40
68	DC.cDC2.monocyte_like	8.75	Significant	0.09	1.56	Relevant	1,285	791
69	IPSC.canonical_pluripotent	8.64	Significant	1.00	0.00	—	0	0
70	EPI.pancreatic_ductal_bicarbonate.stress	8.63	Significant	—	0.22	—	12	33
71	EPI.pancreatic_ductal_bicarbonate.activated	8.54	Significant	0.81	1.04	—	10	7
72	MAC.alveolar.inflammatory	8.39	Significant	0.62	1.07	Relevant	208	312
73	PLAT.adhesion	8.28	Significant	—	0.00	Relevant	0	0
74	MAC.kupffer.inflammatory	8.28	Significant	—	0.95	Relevant	7	4
75	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	8.24	Significant	—	0.08	Relevant	49	237
76	MONO.CD16.hepatic_mac_like	8.03	Significant	0.53	1.15	—	803	117
77	MONO.CD14.APC_like	7.98	Significant	1.00	0.05	Relevant	1,686	2,493
78	HPC.LMPP	7.84	Significant	0.95	0.82	—	65	31
79	THYMO.proliferative_G2M	7.82	Significant	—	1.93	Specific	164	413
80	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	7.75	Significant	—	0.00	—	6	9
81	NEU.INH_VIP.excitatory_coupled	7.66	Significant	—	0.31	—	13	0
82	MAC.alveolar.capillary_interacting	7.51	Significant	0.62	1.06	Relevant	113	181
83	NEU.INH_VIP.opioid	7.37	Significant	—	0.24	—	50	9
84	MONO.CD14.repair_M2_like	6.99	Significant	1.00	0.26	Relevant	550	1,495
85	EPI.pancreatic_islet.beta	6.96	Significant	0.15	1.30	Relevant	42	57
86	EPI.pancreatic_islet.delta	6.92	Significant	—	0.67	Relevant	0	0
87	EPI.esophageal_suprabasal.proliferative_exit	6.70	Significant	—	1.35	Relevant	0	0
88	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	6.52	Significant	0.98	0.30	Relevant	219	533
89	EPI.pancreatic_ductal_bicarbonate.baseline	6.41	Significant	0.98	0.27	Relevant	11	42
90	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	6.30	Significant	—	0.00	—	0	0
91	NEU.INH_VIP.serotonergic	6.25	Significant	—	0.00	—	9	2
92	OLG.stress	6.13	Significant	1.64e-03	2.02	Specific	232	8
93	OLG.reactive_repair	6.08	Significant	0.06	1.77	Relevant	385	385
94	EPI.esophageal_suprabasal.proliferative_S	6.04	Significant	—	0.77	Relevant	26	41
95	EPI.bile_duct_cholangiocyte.inflammatory_APC	5.98	Significant	—	0.22	Other	2	0
96	NEU.INH_VIP.canonical_disinhibitory	5.86	Significant	0.80	0.65	—	59	38
97	EPI.skin_keratinocyte_proliferating.early_spinous_transition	5.75	Significant	—	0.75	Relevant	135	290
98	OLG.vesicle_trafficking	5.74	Significant	0.22	1.46	Relevant	124	10
99	DC.cDC2.proliferative	5.60	Significant	—	0.80	Relevant	39	71
100	MAC.kupffer.fibrogenic	5.59	Significant	—	0.88	Relevant	0	0
101	OLG.regulatory	5.56	Significant	0.98	0.85	Other	353	73
102	GRNLSA.secretory_remodeling	5.55	Significant	0.91	1.18	Other	90	25
103	DC.cDC1.proliferative	5.43	Nominal	—	1.53	Relevant	0	0
104	OLG.myelinating_stress	5.38	Nominal	0.72	1.06	Other	232	62
105	CM.inflammatory	5.35	Nominal	—	2.56	Other	0	0
106	IPSC.endoderm_primed	5.16	Nominal	1.00	0.02	Other	0	0
107	NEU.INH_VIP.regulatory_remodeling	5.13	Nominal	—	0.00	Other	6	1
108	MAC.alveolar.lipid_autophagy	5.10	Nominal	—	0.00	Other	35	44
109	MONO.CD16.patrolling	5.03	Nominal	1.00	0.25	Other	797	216
110	EPI.esophageal_suprabasal.basal_transitional	4.95	Nominal	0.66	1.25	Other	44	67
111	OLG.myelinating_mature	4.87	Nominal	0.98	0.69	Other	363	94
112	DC.cDC2.migratory	4.83	Nominal	0.94	1.14	Other	185	39
113	MAC.alveolar.stress_metabolic	4.77	Nominal	1.00	0.00	Other	116	148
114	EPI.esophageal_suprabasal.differentiating_keratin	4.65	Nominal	0.90	0.43	Other	131	61
115	MONO.CD16.platelet_bound	4.64	Nominal	0.75	0.89	Other	372	508
116	OLG.regulatory_activated	4.59	Nominal	0.98	0.32	Other	196	614
117	NEU.INH_VIP.develop_niche	4.57	Nominal	—	0.00	Other	0	0
118	EPI.colonic_enteroendocrine.progenitor	4.56	Nominal	—	0.97	Other	0	0
119	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	4.34	Nominal	—	0.00	Other	0	0
120	GRNLSA.EMT_insulin_signaling	4.27	Nominal	0.98	0.86	Other	47	84
121	THYMO.proliferative_S	4.23	Nominal	8.70e-05	1.82	Other	163	418
122	EPI.pancreatic_ductal_perivascular.baseline	3.88	Nominal	0.10	1.71	Other	1	5
123	EPI.ectocervical_granular.proliferative_basal	3.81	Nominal	—	1.15	Other	0	0
124	HPC.GMP_inflammatory	3.80	Nominal	0.99	0.26	Other	20	10
125	MAC.kupffer.stress	3.73	Nominal	0.63	0.85	Other	9	3
126	EPI.skin_interfollicular_spinous.stress_UPR	3.64	Nominal	—	0.84	Other	0	0
127	EPI.skin_keratinocyte_proliferating.anchor_remodel	3.53	Nominal	—	0.00	Other	0	0
128	EPI.pancreatic_ductal_perivascular.protective_antioxidant	3.47	Nominal	—	0.00	Other	11	69
129	EPI.endocervical_secretory.secretory_translocon	3.37	Nominal	—	0.67	Other	0	0
130	EPI.skin_interfollicular_spinous.early_differentiation	3.33	Nominal	0.16	1.69	Other	89	19
131	EPI.skin_interfollicular_spinous.stress_oxidative	3.32	Nominal	—	0.46	Other	0	0
132	EPI.skin_interfollicular_spinous.baseline	3.24	Nominal	0.40	1.25	Other	35	3
133	GRNLSA.stress_metabolic	3.22	Nominal	—	0.04	Other	1	2
134	ASTRO.immature_lipid	3.18	Nominal	0.17	1.78	Other	23	113
135	EPI.cervical_suprabasal.secretory_vesicle	3.16	Nominal	—	0.00	Other	0	0
136	DC.cDC2.tolerogenic_regulatory	3.04	Nominal	0.94	0.63	Other	44	4
137	EPI.pancreatic_acinar.inflammatory_regenerative	3.03	Nominal	1.00	0.85	Other	25	113
138	MEL.dedifferentiated_migratory	2.98	Nonsignificant	—	0.74	Other	0	0
139	MAC.kupffer.tolerogenic	2.95	Nonsignificant	—	0.03	Other	45	49
140	EPI.colonic_tuft.homeostatic	2.84	Nonsignificant	—	0.42	Other	0	0
141	NEU.INH_VIP.LAMP5_hybrid	2.81	Nonsignificant	—	0.00	Other	1	9
142	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.81	Nonsignificant	—	0.46	Other	105	368
143	ASTRO.synaptic_interaction	2.80	Nonsignificant	0.30	1.49	Other	76	334
144	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	2.80	Nonsignificant	—	0.42	Other	0	0
145	NEU.INH_LAMP5.exc_inh_balance	2.76	Nonsignificant	—	0.94	Other	46	2
146	ASTRO.homeostatic	2.76	Nonsignificant	0.74	1.13	Other	200	431
147	EPI.pancreatic_acinar.baseline	2.74	Nonsignificant	0.33	1.17	Other	274	163
148	MAC.MDM.inflammatory_phagocytic	2.72	Nonsignificant	0.29	1.36	Other	199	52
149	ASTRO.stress_mito	2.70	Nonsignificant	0.90	0.99	Other	47	110
150	ASTRO.hypoxia_angiogenic	2.67	Nonsignificant	0.60	1.37	Other	5	18
151	MAC.proliferating.stress	2.66	Nonsignificant	—	0.72	Other	87	136
152	T.CD4_naive.activated_stress	2.64	Nonsignificant	0.37	1.27	Other	339	429
153	DC.cDC2.adhesion_signaling	2.63	Nonsignificant	0.94	0.96	Other	35	9
154	MEL.mature_oxidative_traffic	2.62	Nonsignificant	0.11	1.33	Other	247	285
155	EPI.salivary_duct_excretory.stress	2.60	Nonsignificant	0.39	1.42	Other	33	68
156	EPI.skin_keratinocyte_basal.spinous_transition	2.57	Nonsignificant	—	0.97	Other	0	0
157	DC.cDC2.pro_inflammatory	2.51	Nonsignificant	0.94	0.65	Other	3	5
158	EPI.salivary_duct_excretory.baseline	2.49	Nonsignificant	0.39	1.09	Other	23	57
159	EPI.skin_keratinocyte_basal.transit_amplifying	2.48	Nonsignificant	—	0.00	Other	0	0
160	NEU.INH_VIP.enkephalinergic	2.47	Nonsignificant	—	0.00	Other	0	0
161	ASTRO.A2_reactive	2.44	Nonsignificant	0.93	0.87	Other	10	37
162	DC.cDC1.cross_presenting	2.44	Nonsignificant	—	0.36	Other	0	0
163	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	2.43	Nonsignificant	—	0.00	Other	0	0
164	DC.cDC1.activated	2.40	Nonsignificant	—	0.32	Other	0	0
165	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.39	Nonsignificant	—	0.22	Other	0	0
166	EPI.bile_duct_cholangiocyte.secretory_mucin	2.38	Nonsignificant	—	0.00	Other	7	12
167	GRNLSA.lipid_hypoxia	2.35	Nonsignificant	0.98	0.70	Other	28	0
168	ASTRO.stress_acute	2.33	Nonsignificant	1.00	0.71	Other	60	56
169	EPI.pancreatic_acinar.stress	2.33	Nonsignificant	1.00	0.93	Other	28	28
170	EPI.pancreatic_ductal_progenitor.baseline	2.32	Nonsignificant	0.52	0.96	Other	179	702
171	EPI.esophageal_basal.junctional_barrier	2.31	Nonsignificant	—	1.01	Other	0	0
172	EPI.colonic_tuft.activated	2.27	Nonsignificant	—	0.00	Other	0	0
173	CM.mechano_activated	2.21	Nonsignificant	0.31	1.45	Other	205	134
174	EPI.skin_interfollicular_spinous.proliferative	2.21	Nonsignificant	—	0.00	Other	0	0
175	EPI.thymic_cortical.Notch_interface	2.17	Nonsignificant	—	1.07	Other	82	137
176	EPI.endocervical_secretory.squamous_barrier	2.16	Nonsignificant	—	0.00	Other	0	0
177	EPI.skin_interfollicular_spinous.upper_lipid	2.13	Nonsignificant	—	0.00	Other	6	6
178	MAC.MDM.LAM_like	2.10	Nonsignificant	0.40	1.28	Other	12	14
179	THYMO.SP_CD4_naive	2.05	Nonsignificant	0.02	1.59	Other	65	75
180	EPI.thymic_cortical.baseline	2.05	Nonsignificant	0.24	1.46	Other	185	386
181	SCHWN.axon_contact_cardiac	1.98	Nonsignificant	0.06	1.50	Other	18	63
182	EPI.cervical_suprabasal.inflammatory_repair	1.97	Nonsignificant	—	0.00	Other	0	0
183	EPI.tracheal_suprabasal.transitional_wound	1.94	Nonsignificant	—	0.43	Other	16	1
184	EPI.extrahepatic_cholangiocyte.barrier_interface	1.94	Nonsignificant	—	0.73	Other	0	0
185	EPI.skin_interfollicular_spinous.transition_basal	1.88	Nonsignificant	0.99	0.17	Other	100	127
186	MAC.MDM.APC_dendritic	1.85	Nonsignificant	0.78	0.95	Other	48	15
187	ASTRO.neuromodulatory	1.78	Nonsignificant	1.00	0.54	Other	34	172
188	EPI.pancreatic_ductal_progenitor.ADM_like	1.78	Nonsignificant	—	0.00	Other	0	0
189	HEP.periportal_metabolic.inflammatory_activated	1.74	Nonsignificant	0.07	1.22	Other	712	1,610
190	SKM.type_1_slow.oxidative	1.73	Nonsignificant	2.49e-03	2.41	Other	802	251
191	GRNLSA.p53_damage	1.72	Nonsignificant	—	0.00	Other	13	10
192	CM.translation_boost_RPL	1.71	Nonsignificant	0.32	1.30	Other	129	1
193	CM.oxidative_phospho	1.71	Nonsignificant	0.29	1.46	Other	266	792
194	CM.translation_boost_RPS	1.70	Nonsignificant	0.48	1.21	Other	69	16
195	CM.mito_proteostasis	1.65	Nonsignificant	0.10	1.61	Other	329	29
196	DC.cDC2.antiviral	1.64	Nonsignificant	0.94	0.58	Other	100	37
197	HPC.GMP_granulocytic	1.62	Nonsignificant	—	0.00	Other	3	3
198	DC.cDC1.homeostatic_inhibitory	1.61	Nonsignificant	—	0.00	Other	0	0
199	EPI.tracheal_basal.homeostatic_progenitor	1.57	Nonsignificant	0.03	2.03	Other	285	74
200	CM.sarcomere_actin_interface	1.53	Nonsignificant	0.31	1.26	Other	450	78
201	B.germinal_center.DZ_M_phase	1.52	Nonsignificant	—	1.47	Other	0	0
202	SKM.type_1_slow.contractile	1.51	Nonsignificant	1.00	0.67	Other	596	8
203	EPI.salivary_intercalated_defense.inflammatory	1.47	Nonsignificant	0.02	1.54	Other	152	360
204	GRNLSA.cholesterol_mevalonate	1.46	Nonsignificant	0.98	0.33	Other	9	4
205	CM.anti_inflammatory	1.46	Nonsignificant	1.00	0.71	Other	424	1,503
206	EPI.thymic_cortical.secretory_remodeling	1.46	Nonsignificant	—	0.00	Other	4	1
207	ASTRO.A1_reactive	1.43	Nonsignificant	1.00	0.03	Other	433	394
208	CM.baseline	1.37	Nonsignificant	1.00	0.53	Other	393	0
209	HEP.periportal_metabolic.apolipoprotein_secretory	1.34	Nonsignificant	0.55	1.18	Other	43	110
210	GRANU.neutrophil.tissue_patrolling	1.31	Nonsignificant	—	0.52	Other	0	0
211	EPI.ectocervical_granular.inflammatory	1.29	Nonsignificant	—	0.32	Other	0	0
212	EPI.esophageal_basal.activated_progenitor	1.26	Nonsignificant	1.00	0.00	Other	1	0
213	SKM.type_1_slow.glycolytic	1.24	Nonsignificant	1.00	0.00	Other	362	647
214	GRNLSA.chemokine_mechanosensory	1.24	Nonsignificant	0.98	0.23	Other	1	0
215	GRANU.neutrophil.antiviral_endotoxin	1.23	Nonsignificant	—	0.64	Other	0	0
216	CM.osmoprotection	1.20	Nonsignificant	1.00	0.28	Other	34	57
217	THYMO.DP_early	1.13	Nonsignificant	0.28	1.22	Other	326	313
218	NEU.INH_LAMP5.glial_interface	1.10	Nonsignificant	—	0.00	Other	0	0
219	HPC.CLP_B_primed	1.08	Nonsignificant	—	0.00	Other	0	0
220	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.06	Nonsignificant	8.42e-03	1.53	Other	322	317
221	EPI.tracheal_basal.activated_stress	1.06	Nonsignificant	0.98	0.02	Other	32	0
222	THYMO.SP_CD8_transitional	1.01	Nonsignificant	0.97	0.96	Other	32	75
223	MAC.MDM.complement_resolving	1.01	Nonsignificant	0.99	0.45	Other	440	860
224	MAC.resident_iron.APC_iron_sensing	0.93	Nonsignificant	0.69	1.19	Other	211	114
225	EPI.skin_follicular_keratinizing.root_infundibulum	0.92	Nonsignificant	—	0.33	Other	0	0
226	EC.lymphatic.activated	0.89	Nonsignificant	0.33	1.16	Other	47	73
227	PC.IgG_systemic.metabolic	0.85	Nonsignificant	0.17	1.44	Other	46	63
228	MEL.neurotrophic_migratory	0.83	Nonsignificant	—	0.00	Other	0	0
229	EPI.skin_follicular_keratinizing.upper_infundibulum	0.78	Nonsignificant	—	3.47e-17	Other	8	2
230	SCHWN.translation_boost	0.75	Nonsignificant	—	0.00	Other	8	1
231	NEU.INH_LAMP5.projecting	0.75	Nonsignificant	—	0.00	Other	0	0
232	EPI.skin_follicular_keratinizing.transit_amplifying	0.75	Nonsignificant	—	0.00	Other	21	49
233	EPI.salivary_serous_acinar.quiescent	0.74	Nonsignificant	0.20	1.45	Other	178	493
234	EPI.tracheal_suprabasal.secretory_immune	0.72	Nonsignificant	—	0.00	Other	0	0
235	EPI.colonic_enteroendocrine.Lcell_peptide	0.71	Nonsignificant	—	0.00	Other	0	0
236	NEU.INH_LAMP5.rosehip	0.71	Nonsignificant	—	0.00	Other	0	0
237	ILC2.activated	0.69	Nonsignificant	—	0.00	Other	0	0
238	MAC.kupffer.monocyte_like	0.67	Nonsignificant	—	0.00	Other	0	0
239	EC.lymphatic.tip_migratory	0.66	Nonsignificant	0.33	1.22	Other	23	37
240	MAC.kupffer.metabolic	0.65	Nonsignificant	—	0.00	Other	25	36
241	EPI.renal_thick_ascending_limb.remodeling	0.65	Nonsignificant	1.00	0.85	Other	152	92
242	EPI.skin_interfollicular_spinous.inflammatory	0.65	Nonsignificant	—	0.00	Other	0	0
243	DC.cDC1.baseline	0.64	Nonsignificant	—	0.00	Other	0	0
244	THYMO.DN_preTCR	0.64	Nonsignificant	1.00	0.66	Other	41	71
245	GRANU.neutrophil.primed_degranulation	0.64	Nonsignificant	—	0.00	Other	0	0
246	EPI.renal_thick_ascending_limb.barrier_repair	0.61	Nonsignificant	1.00	0.77	Other	141	284
247	HEP.periportal_metabolic.acute_phase_barrier	0.60	Nonsignificant	1.00	0.95	Other	533	138
248	EPI.renal_proximal_tubule.detox_antioxidant	0.59	Nonsignificant	9.43e-04	2.91	Other	394	77
249	THYMO.DP_early_stress	0.58	Nonsignificant	—	0.00	Other	0	0
250	ILC2.migratory	0.58	Nonsignificant	—	0.44	Other	0	0
251	PC.IgG_systemic.interacting	0.58	Nonsignificant	0.71	1.03	Other	0	0
252	EPI.salivary_serous_acinar.secretory_active	0.57	Nonsignificant	0.65	0.85	Other	242	69
253	HEP.periportal_metabolic.stress_chaperone	0.55	Nonsignificant	—	0.30	Other	66	128
254	MEL.stress_glucocorticoid	0.54	Nonsignificant	1.00	0.73	Other	11	34
255	MAC.proliferating.DNA_replication	0.54	Nonsignificant	0.97	0.37	Other	3	6
256	MAC.resident_repair.lipid_phagocytic	0.52	Nonsignificant	0.58	1.19	Other	228	604
257	FIB.hepatic_stellate_cell.contractile	0.48	Nonsignificant	—	1.15	Other	0	0
258	MEL.secretory_quiescent	0.47	Nonsignificant	1.00	0.30	Other	19	13
259	MAC.resident_iron.stress_tolerogenic	0.46	Nonsignificant	—	0.68	Other	0	0
260	B.germinal_center.LZ_survival	0.46	Nonsignificant	—	0.00	Other	0	0
261	EPI.tracheal_submucosal_gland.acinar_serous	0.46	Nonsignificant	—	0.00	Other	0	0
262	HEP.periportal_metabolic.xenobiotic_detox	0.46	Nonsignificant	1.00	0.92	Other	1,440	139
263	EC.lymphatic.baseline	0.46	Nonsignificant	0.48	1.05	Other	38	72
264	B.germinal_center.DZ_S_phase	0.45	Nonsignificant	—	0.00	Other	0	0
265	FIB.hepatic_stellate_cell.inflammatory	0.45	Nonsignificant	—	0.00	Other	0	0
266	GRANU.MAST.resting_granule	0.44	Nonsignificant	—	0.29	Other	0	0
267	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.44	Nonsignificant	1.00	0.00	Other	58	89
268	EPI.skin_keratinocyte_proliferating.detox_repair	0.44	Nonsignificant	—	0.00	Other	0	0
269	HEP.periportal_metabolic.canonical_urea_cycle	0.44	Nonsignificant	1.00	0.94	Other	1,464	269
270	GRANU.MAST.activated_repair	0.44	Nonsignificant	—	0.09	Other	0	1
271	B.germinal_center.LZ_selection	0.43	Nonsignificant	—	0.00	Other	0	0
272	EPI.alveolar_type_1.baseline	0.43	Nonsignificant	0.11	1.61	Other	8	0
273	EPI.salivary_intercalated_defense.basal_EMT	0.43	Nonsignificant	—	0.00	Other	0	0
274	MAC.resident_repair.stress_iron	0.42	Nonsignificant	0.64	1.12	Other	48	97
275	EPI.tracheal_submucosal_gland.ductal_luminal	0.40	Nonsignificant	—	0.00	Other	0	0
276	FIB.hepatic_stellate_cell.fibrogenic	0.39	Nonsignificant	—	0.00	Other	0	0
277	THYMO.SP_CD8_naive	0.39	Nonsignificant	1.00	0.07	Other	297	177
278	PC.IgG_systemic.stress	0.37	Nonsignificant	—	0.00	Other	1	5
279	EPI.ileal_bile_transport.detox_transcytosis	0.37	Nonsignificant	—	0.00	Other	0	1
280	EPI.ileal_bile_transport.absorptive_xenobiotic	0.36	Nonsignificant	0.40	1.15	Other	11	12
281	B.germinal_center.LZ_memory_precursor	0.36	Nonsignificant	—	0.00	Other	0	0
282	EC.liver_sinusoidal.remodeling_lipotoxicity	0.36	Nonsignificant	—	1.21	Other	90	58
283	FIB.reticular.immune_interface	0.34	Nonsignificant	—	0.68	Other	1	6
284	THYMO.SP_CD8_naive_stress	0.34	Nonsignificant	1.00	0.10	Other	1	1
285	MAC.LAM.lipid_opsonization	0.33	Nonsignificant	0.63	1.08	Other	45	14
286	EPI.renal_thick_ascending_limb.cation_flux	0.32	Nonsignificant	1.00	0.91	Other	57	95
287	FIB.transitioning.ISG_primed_interface	0.32	Nonsignificant	—	0.68	Other	17	80
288	MAC.LAM.inflammatory_APC	0.32	Nonsignificant	0.38	1.07	Other	872	165
289	EPI.pancreatic_islet.alpha	0.30	Nonsignificant	—	0.00	Other	152	330
290	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.30	Nonsignificant	—	0.00	Other	0	0
291	GRANU.MAST.activated_acute	0.29	Nonsignificant	—	0.00	Other	0	0
292	DC.mig.baseline	0.29	Nonsignificant	—	0.00	Other	1	0
293	MAC.resident_repair.chemokine_angiocrine	0.28	Nonsignificant	0.30	1.15	Other	87	138
294	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.28	Nonsignificant	—	1.52	Other	0	0
295	EC.capillary.angiogenic_tip	0.27	Nonsignificant	0.44	1.26	Other	186	218
296	SMC.contractile	0.27	Nonsignificant	5.49e-03	1.34	Other	80	588
297	EPI.pancreatic_acinar.metabolic_onecarbon	0.26	Nonsignificant	1.00	0.18	Other	287	328
298	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.24	Nonsignificant	—	1.42	Other	10	20
299	PC.IgG_systemic.secretory	0.24	Nonsignificant	0.99	0.37	Other	0	0
300	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.23	Nonsignificant	1.00	0.10	Other	11	22
301	T.CD4_Tfh.effector_migratory	0.22	Nonsignificant	1.45e-03	1.44	Other	122	57
302	THYMO.CD8aa_IELp	0.22	Nonsignificant	—	0.00	Other	1	7
303	MAC.resident_cardiac.phagocytic_homeostasis	0.20	Nonsignificant	0.03	1.57	Other	564	1,221
304	B.age_associated.activated	0.20	Nonsignificant	—	0.52	Other	18	22
305	MAC.resident_cardiac.inflammatory_reparative	0.19	Nonsignificant	0.88	0.94	Other	31	96
306	EPI.renal_intercalated_cell_type_A.acid_secretion	0.18	Nonsignificant	0.01	1.56	Other	12	6
307	EPI.ileal_enterocyte_crypt.villus_transition	0.18	Nonsignificant	—	1.67	Other	7	10
308	EPI.ectocervical_granular.secretory_apocrine	0.17	Nonsignificant	—	0.00	Other	0	0
309	EC.liver_sinusoidal.hypoxia_metabolic	0.17	Nonsignificant	0.28	1.25	Other	183	107
310	MAC.resident_repair.antigen_presenting	0.17	Nonsignificant	0.83	0.97	Other	244	113
311	FIB.barrier_secretory.homeostasis	0.16	Nonsignificant	—	0.00	Other	0	0
312	HEP.acute_phase.stress_secretory	0.16	Nonsignificant	0.39	1.34	Other	26	3
313	B.age_associated.migratory	0.14	Nonsignificant	0.57	0.93	Other	2	2
314	PC.IgA_muocsal.plasmablast	0.14	Nonsignificant	0.57	1.15	Other	5	4
315	HEP.periportal_metabolic.stress_checkpoint	0.14	Nonsignificant	1.00	0.72	Other	234	786
316	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.13	Nonsignificant	—	0.97	Other	0	0
317	DC.cDC2.lipid_metabolic	0.13	Nonsignificant	—	0.00	Other	0	0
318	PC.IgA_muocsal.baseline	0.13	Nonsignificant	0.77	0.90	Other	3	5
319	HEP.pericentral_lipoprotein.UPR_redox	0.13	Nonsignificant	—	0.67	Other	0	0
320	FIB.tracheal_subepithelial.baseline	0.13	Nonsignificant	—	0.00	Other	0	0
321	PC.IgA_muocsal.activated	0.13	Nonsignificant	0.37	1.15	Other	17	8
322	T.CD4_transitional.tissue_enagement	0.12	Nonsignificant	0.12	1.31	Other	5	11
323	CM.contractile_oxphos	0.12	Nonsignificant	1.00	8.71e-03	Other	6	19
324	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.12	Nonsignificant	—	0.00	Other	0	0
325	MAC.microglia_like.inflammatory_chemokine	0.12	Nonsignificant	—	0.16	Other	20	32
326	MAC.resident_iron.heme_catabolism	0.12	Nonsignificant	0.78	0.97	Other	30	51
327	EC.liver_sinusoidal.stress	0.12	Nonsignificant	—	0.00	Other	413	158
328	HEP.pericentral_lipoprotein.ApoB_coagulation	0.11	Nonsignificant	—	0.00	Other	0	0
329	FIB.transitioning.matrix_stress	0.11	Nonsignificant	—	0.00	Other	47	138
330	EPI.ectocervical_granular.immune_interact	0.11	Nonsignificant	—	0.00	Other	0	0
331	EPI.ileal_enterocyte_absorptive.villus_tip	0.11	Nonsignificant	2.67e-08	1.60	Other	4	3
332	EC.arterial.elastic	0.11	Nonsignificant	0.14	1.19	Other	22	45
333	NK.immature_bridge	0.11	Nonsignificant	0.50	1.05	Other	117	122
334	T.CD4_transitional.primed_helper_effector	0.10	Nonsignificant	0.24	1.17	Other	19	43
335	PC.IgA_muocsal.migratory	0.10	Nonsignificant	0.77	0.92	Other	4	1
336	HEP.acute_phase.baseline	0.09	Nonsignificant	0.39	1.12	Other	946	19
337	T.CD4_Tem.inflammatory	0.09	Nonsignificant	0.23	1.19	Other	28	6
338	EPI.pancreatic_acinar.adhesion_remodeling	0.09	Nonsignificant	1.00	0.06	Other	210	784
339	MAC.microglia_like.phagocytic_redox	0.09	Nonsignificant	—	0.00	Other	0	0
340	MAC.resident_cardiac.antigen_presenting	0.08	Nonsignificant	1.00	0.28	Other	52	27
341	T.CD4_Tfh.suppression_exhaustion	0.08	Nonsignificant	0.73	1.13	Other	0	2
342	EPI.gastric_foveolar.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
343	T.CD4_Treg.Tr1_like	0.08	Nonsignificant	—	0.93	Other	8	8
344	SKM.type_2_fast.oxidative_IIa	0.08	Nonsignificant	0.88	1.06	Other	946	56
345	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.08	Nonsignificant	—	0.32	Other	0	0
346	HEP.canalicular_transport.secretory_ERAD_UPR	0.08	Nonsignificant	0.86	0.98	Other	232	28
347	EPI.lung_multiciliated.mature_motile_cilia	0.07	Nonsignificant	—	1.53	Other	0	0
348	FIB.transitioning.secretory_procollagen	0.07	Nonsignificant	—	0.00	Other	0	0
349	MAC.LAM.anti_inflammatory	0.07	Nonsignificant	0.70	1.00	Other	86	132
350	T.CD8_Trm.dendritic_recruiter	0.07	Nonsignificant	0.66	1.16	Other	47	85
351	T.CD4_transitional.APC_interacting	0.07	Nonsignificant	0.37	1.14	Other	10	14
352	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.07	Nonsignificant	—	0.00	Other	0	0
353	EPI.alveolar_type_1.activated	0.07	Nonsignificant	—	0.00	Other	0	0
354	FIB.reticular.stress_metallothionein	0.06	Nonsignificant	—	8.52e-03	Other	3	32
355	MG.baseline	0.06	Nonsignificant	0.12	1.40	Other	16	5
356	MAC.resident_iron.redox_metabolic	0.06	Nonsignificant	0.78	0.85	Other	4	4
357	HEP.canalicular_transport.inflammatory	0.06	Nonsignificant	0.60	1.07	Other	1,335	194
358	SMC.metabolic	0.06	Nonsignificant	0.99	0.64	Other	14	40
359	EPI.ileal_enterocyte_crypt.bile_transport	0.06	Nonsignificant	1.00	1.02	Other	2	0
360	T.CD4_cytotoxic.precursor	0.06	Nonsignificant	0.61	1.25	Other	156	67
361	NK.cytokine_tissue_resident	0.06	Nonsignificant	1.00	1.11	Other	74	82
362	HEP.canalicular_transport.injury_stress	0.06	Nonsignificant	0.60	1.06	Other	289	24
363	HEP.acute_phase.inflammatory	0.06	Nonsignificant	0.86	1.00	Other	382	649
364	FIB.reticular.stromal_niche	0.06	Nonsignificant	0.80	0.71	Other	0	0
365	T.CD4_Th17.cytotoxic	0.05	Nonsignificant	0.85	1.10	Other	332	123
366	T.CD4_transitional.baseline	0.05	Nonsignificant	0.85	0.89	Other	59	97
367	EPI.skin_keratinocyte_progenitor.activated_stress	0.05	Nonsignificant	—	0.00	Other	0	0
368	FIB.perivascular_interface.vasomotor_tone	0.05	Nonsignificant	—	0.85	Other	0	0
369	EPI.colonocyte.distal_absorptive	0.05	Nonsignificant	—	1.95	Other	0	0
370	EPI.lung_club_secretory.canonical_surfactant	0.05	Nonsignificant	—	0.87	Other	74	104
371	MAC.LAM.antimicrobial	0.05	Nonsignificant	0.38	1.15	Other	389	93
372	FIB.barrier_secretory.remodeling	0.05	Nonsignificant	—	0.00	Other	0	0
373	T.CD4_transitional.primed_cytotoxic	0.05	Nonsignificant	0.85	0.86	Other	28	30
374	EC.liver_sinusoidal.prostanoid	0.05	Nonsignificant	—	0.00	Other	11	64
375	FIB.perivascular_interface.vascular_BM_remodelling	0.05	Nonsignificant	—	0.41	Other	0	0
376	FIB.adventitial.inflammatory_activated	0.05	Nonsignificant	0.55	1.16	Other	100	473
377	T.CD4_Trm.stress_adaptive	0.05	Nonsignificant	0.23	1.26	Other	8	22
378	B.memory.activated	0.05	Nonsignificant	6.86e-03	1.27	Other	105	29
379	T.CD4_Trm.activated	0.05	Nonsignificant	0.79	1.07	Other	32	26
380	T.CD4_Trm.baseline	0.05	Nonsignificant	0.23	1.15	Other	31	21
381	T.CD8_Tem.signaling_turnover	0.05	Nonsignificant	0.38	1.14	Other	425	683
382	MAC.resident_repair.ECM_stromal_crosstalk	0.04	Nonsignificant	0.95	0.76	Other	95	158
383	B.age_associated.naive_transitional	0.04	Nonsignificant	—	0.00	Other	0	0
384	T.CD4_naive.neddylation_mitoprot	0.04	Nonsignificant	0.99	1.09	Other	93	56
385	MAC.resident_iron.heme_recycling	0.04	Nonsignificant	—	0.00	Other	30	37
386	EC.capillary.activated	0.04	Nonsignificant	0.87	1.21	Other	2	5
387	B.naive.activated	0.04	Nonsignificant	0.28	1.21	Other	77	127
388	T.CD4_naive.gut_prone	0.04	Nonsignificant	0.99	1.18	Other	35	70
389	HEP.canalicular_transport.pericentral_like_hypoxia	0.04	Nonsignificant	0.60	1.14	Other	326	8
390	FIB.suburothelial.inflammatory_prostanoid	0.04	Nonsignificant	—	0.95	Other	0	0
391	FIB.transitioning.motility_remodelling	0.04	Nonsignificant	—	0.00	Other	0	0
392	T.CD4_Tfh.precursor_migratory	0.04	Nonsignificant	0.95	0.71	Other	72	27
393	EPI.skin_keratinocyte_basal.basement_anchoring	0.04	Nonsignificant	—	0.00	Other	0	0
394	EC.heart_remodeling.angiocrine	0.04	Nonsignificant	0.02	1.17	Other	182	525
395	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.04	Nonsignificant	0.03	1.28	Other	7	16
396	HEP.acute_phase.proliferative	0.04	Nonsignificant	—	0.32	Other	4	6
397	NK.cytokine_lung_immediate_early	0.04	Nonsignificant	1.00	1.06	Other	424	274
398	EC.lymphatic.valve	0.04	Nonsignificant	—	0.00	Other	0	0
399	T.CD4_naive.Treg_like	0.03	Nonsignificant	0.99	1.23	Other	121	72
400	PERI.baseline	0.03	Nonsignificant	4.77e-03	1.21	Other	39	66
401	SMC.activated	0.03	Nonsignificant	0.99	0.49	Other	2	5
402	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.03	Nonsignificant	—	0.00	Other	19	54
403	T.CD4_Tfh.canonical_GC_helper	0.03	Nonsignificant	0.95	0.53	Other	1	2
404	FIB.suburothelial.contractile_myofibroblast	0.03	Nonsignificant	—	0.39	Other	9	0
405	FIB.skin_neurosecretory.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
406	EC.lymphatic.scavenger	0.03	Nonsignificant	1.00	0.39	Other	203	257
407	MG.expanding	0.03	Nonsignificant	0.89	0.69	Other	2	1
408	HEP.acute_phase.complement_metabolic	0.03	Nonsignificant	0.97	0.73	Other	1,423	3,464
409	EC.liver_sinusoidal.inflammatory	0.03	Nonsignificant	—	0.00	Other	223	154
410	FIB.suburothelial.urothelial_interface	0.03	Nonsignificant	1.00	0.93	Other	9	8
411	HEP.acute_phase.complement_antiviral	0.03	Nonsignificant	0.97	0.82	Other	377	751
412	MUSC.baseline	0.03	Nonsignificant	0.22	1.45	Other	0	0
413	MUSC.activated_migratory	0.03	Nonsignificant	0.22	1.59	Other	6	7
414	ASPC.remodeling	0.03	Nonsignificant	0.62	1.11	Other	106	354
415	FIB.skin_sheath.stress_chaperone	0.03	Nonsignificant	—	0.35	Other	0	0
416	MG.phagocytic_APC	0.03	Nonsignificant	0.89	0.56	Other	25	8
417	FIB.barrier_purinergic.lipid_secretory	0.03	Nonsignificant	—	0.48	Other	0	0
418	FIB.perivascular_interface.lipid_shuttle	0.02	Nonsignificant	—	0.00	Other	51	170
419	MAC.microglia_like.patrolling_adhesive	0.02	Nonsignificant	—	0.00	Other	0	0
420	SCHWN.reactive_inflammatory	0.02	Nonsignificant	—	0.00	Other	0	0
421	EC.capillary.inflammatory	0.02	Nonsignificant	0.98	1.01	Other	27	51
422	FIB.skin_sheath.ECM_immune	0.02	Nonsignificant	—	0.00	Other	0	0
423	B.memory.migratory	0.02	Nonsignificant	0.62	1.09	Other	123	208
424	EPI.lung_club_secretory.ciliogenesis_primed	0.02	Nonsignificant	—	0.00	Other	0	0
425	HEP.canalicular_transport.ductular_like_transition	0.02	Nonsignificant	0.94	0.80	Other	400	87
426	T.MAIT.early_activation	0.02	Nonsignificant	3.87e-03	1.52	Other	57	4
427	HEP.acute_phase.hypoxia_lipid	0.02	Nonsignificant	—	0.03	Other	0	0
428	EPI.thymic_medullary.canonical_alarmin	0.02	Nonsignificant	0.14	1.55	Other	8	17
429	EPI.renal_distal_tubule.immune_modulatory	0.02	Nonsignificant	—	1.34	Other	0	0
430	ASPC.proliferative	0.02	Nonsignificant	0.62	1.25	Other	33	85
431	FIB.lung_alveolar.mito_secretory	0.02	Nonsignificant	—	0.00	Other	0	0
432	EC.arterial.arteriole_interface	0.02	Nonsignificant	0.06	1.21	Other	31	12
433	T.CD4_Trm.cytotoxic_effector	0.02	Nonsignificant	0.94	0.86	Other	118	77
434	B.naive.restrained	0.02	Nonsignificant	0.25	1.16	Other	183	353
435	EPI.thymic_medullary.proliferative_APC	0.02	Nonsignificant	—	0.56	Other	0	0
436	HEP.canalicular_transport.baseline	0.02	Nonsignificant	0.94	0.82	Other	199	477
437	HEP.periportal_metabolic.urea_onecarbon_secretory	0.02	Nonsignificant	1.00	0.68	Other	1,332	3,053
438	EPI.lung_club_secretory.inflammatory	0.02	Nonsignificant	—	0.00	Other	0	0
439	T.CD4_Trm.central_like	0.02	Nonsignificant	0.79	1.05	Other	38	31
440	T.CD8_transitional.early	0.02	Nonsignificant	0.46	1.05	Other	327	55
441	ASPC.secretory	0.02	Nonsignificant	0.62	1.07	Other	76	5
442	EPI.skin_hair_follicle_companion.activated_migratory	0.01	Nonsignificant	—	0.00	Other	0	0
443	ASPC.adipocyte_capillary_interface	0.01	Nonsignificant	0.77	1.07	Other	21	54
444	EPI.renal_intercalated_cell_type_B.baseline	0.01	Nonsignificant	—	0.00	Other	3	1
445	CHOND.pro_inflammatory	0.01	Nonsignificant	0.26	1.21	Other	181	351
446	PERI.inflammatory	0.01	Nonsignificant	0.63	1.01	Other	40	77
447	FIB.lung_alveolar.stress_interacting	0.01	Nonsignificant	—	0.00	Other	0	0
448	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.01	Nonsignificant	0.46	1.21	Other	449	1,034
449	ASPC.inflammatory	0.01	Nonsignificant	0.65	1.12	Other	21	61
450	T.CD4_Trm.helper_like	0.01	Nonsignificant	0.94	0.73	Other	84	147
451	T.CD8_Tcm.baseline	0.01	Nonsignificant	0.59	1.14	Other	90	89
452	T.CD4_Tem.transitional_CM	0.01	Nonsignificant	1.00	0.84	Other	31	20
453	EC.liver_sinusoidal.secretory_lipoprotein	0.01	Nonsignificant	1.00	0.22	Other	120	70
454	EC.venous.baseline	0.01	Nonsignificant	0.29	1.08	Other	346	807
455	FIB.reticular.ECM_builder	0.01	Nonsignificant	—	0.00	Other	0	0
456	B.memory.preactivated	0.01	Nonsignificant	0.62	1.06	Other	173	174
457	ILC2.quiescent	0.01	Nonsignificant	—	0.00	Other	0	0
458	MUSC.quiescent_reservoir	0.01	Nonsignificant	0.97	0.38	Other	2	8
459	T.CD8_transitional.Trm_primed	0.01	Nonsignificant	0.46	1.10	Other	108	15
460	FIB.adventitial.adhesion_lipid	0.01	Nonsignificant	0.97	1.10	Other	58	209
461	FIB.suburothelial.homeostasis_matrix	0.01	Nonsignificant	1.00	0.00	Other	258	921
462	EC.venous.cardiac_structural	0.01	Nonsignificant	0.47	1.17	Other	102	229
463	T.CD4_Tcm.Th2_like	0.01	Nonsignificant	0.77	1.13	Other	23	55
464	FIB.skin_sheath.neuro_vascular_interface	0.01	Nonsignificant	—	6.94e-17	Other	0	0
465	FIB.neurolectin_mucosa.nerve_interface	0.01	Nonsignificant	—	0.69	Other	4	0
466	ASPC.stem_like_progenitor	0.01	Nonsignificant	0.88	0.91	Other	300	842
467	ASPC.preadipocyte_lipid_primed	0.01	Nonsignificant	0.62	1.08	Other	331	129
468	FIB.interstitial.mesenchymal_regulator	0.01	Nonsignificant	0.66	1.13	Other	4	4
469	EPI.renal_intercalated_cell_type_A.PC_transitional	9.47e-03	Nonsignificant	—	0.00	Other	203	407
470	T.CD8_transitional.effector_primed	9.40e-03	Nonsignificant	0.46	1.04	Other	435	151
471	EPI.thymic_medullary.stress_APC	9.39e-03	Nonsignificant	0.96	0.37	Other	2	4
472	NK.adaptive_axis_baseline	8.96e-03	Nonsignificant	5.72e-03	1.09	Other	1,008	153
473	EC.arterial.homeostatic	8.88e-03	Nonsignificant	0.99	0.93	Other	24	3
474	MESO.baseline	8.88e-03	Nonsignificant	0.09	1.46	Other	0	6
475	EPI.alveolar_type_2.baseline_surfactant	8.85e-03	Nonsignificant	0.41	1.14	Other	64	9
476	EPI.thymic_medullary.hormone_xeno_barrier	8.66e-03	Nonsignificant	—	0.00	Other	0	8
477	ASPC.niche_keeping_progenitor	8.64e-03	Nonsignificant	0.88	0.89	Other	52	219
478	T.CD8_Trm.inflammatory	8.58e-03	Nonsignificant	0.87	1.03	Other	124	176
479	EC.capillary.postcap_venule	8.40e-03	Nonsignificant	0.98	1.02	Other	355	261
480	T.CD4_Tem.long_term_memory	8.29e-03	Nonsignificant	1.00	0.87	Other	314	587
481	T.CD4_Trm.metal_stress	8.26e-03	Nonsignificant	0.94	0.67	Other	34	58
482	MUSC.early_activation	8.15e-03	Nonsignificant	0.97	0.11	Other	4	32
483	T.CD8_naive.splicing_enriched	8.14e-03	Nonsignificant	0.52	1.14	Other	120	16
484	EC.venous.adipose_lipid	8.09e-03	Nonsignificant	0.11	1.26	Other	254	476
485	MESO.activated_migratory	7.67e-03	Nonsignificant	—	0.19	Other	0	0
486	MESO.secretory_structural	7.63e-03	Nonsignificant	—	0.12	Other	0	0
487	ASPC.baseline	7.59e-03	Nonsignificant	0.88	0.95	Other	363	170
488	T.CD8_Tem.baseline	7.42e-03	Nonsignificant	0.83	1.02	Other	458	356
489	CHOND.angiogenic	7.28e-03	Nonsignificant	—	1.03	Other	0	0
490	T.CD8_Trm.homeostatic	7.22e-03	Nonsignificant	0.95	0.94	Other	42	5
491	EC.capillary.baseline	7.08e-03	Nonsignificant	0.99	0.81	Other	246	560
492	EC.heart_remodeling.translation_boost	6.96e-03	Nonsignificant	—	0.68	Other	0	0
493	T.CD4_Treg.tissue_effector	6.93e-03	Nonsignificant	0.57	1.26	Other	16	13
494	EPI.ileal_enterocyte_crypt.secretory_precursor	6.89e-03	Nonsignificant	—	0.04	Other	0	0
495	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	6.87e-03	Nonsignificant	—	0.92	Other	0	0
496	T.CD8_Trm.muscosal_Tc17	6.69e-03	Nonsignificant	0.87	1.01	Other	19	38
497	ADIPO.inflammatory	6.59e-03	Nonsignificant	—	0.97	Other	0	0
498	FIB.neurolectin_mucosa.axon_responsive	6.51e-03	Nonsignificant	0.62	1.09	Other	10	10
499	EPI.colonocyte.crypt_progenitor	6.50e-03	Nonsignificant	0.90	1.13	Other	115	265
500	T.CD4_naive.survival_mitoprot	6.26e-03	Nonsignificant	0.99	1.05	Other	13	7
501	T.CD8_naive.vesicle_secretory	6.24e-03	Nonsignificant	0.29	1.28	Other	42	0
502	MESO.activated_stress	6.17e-03	Nonsignificant	—	0.00	Other	0	0
503	T.CD4_Tcm.tissue_homing	6.13e-03	Nonsignificant	0.77	1.08	Other	78	46
504	CHOND.remodeling	6.12e-03	Nonsignificant	—	0.36	Other	5	0
505	EPI.skin_hair_follicle_bulge.quiescent	6.09e-03	Nonsignificant	0.22	1.30	Other	56	69
506	T.CD4_Tcm.effector_like	6.09e-03	Nonsignificant	0.87	1.03	Other	293	533
507	T.CD8_Tem.early_helper_like	6.01e-03	Nonsignificant	0.83	1.05	Other	445	755
508	FIB.skin_tenogenic.baseline	5.91e-03	Nonsignificant	—	0.00	Other	0	2
509	EPI.skin_hair_follicle_bulge.anagen_growth	5.90e-03	Nonsignificant	—	0.46	Other	0	0
510	FIB.interstitial.lipid_matrix	5.85e-03	Nonsignificant	0.31	1.17	Other	258	191
511	PERI.angiocrine	5.68e-03	Nonsignificant	0.96	0.84	Other	93	102
512	EPI.colonocyte.proximal_transport	5.48e-03	Nonsignificant	0.90	0.97	Other	24	12
513	B.naive.baseline	5.42e-03	Nonsignificant	0.99	1.02	Other	10	13
514	B.naive.metabolic	5.41e-03	Nonsignificant	0.99	0.93	Other	50	79
515	EC.venous.quiescent_homeostatic	5.10e-03	Nonsignificant	0.79	0.97	Other	456	360
516	T.CD4_Tcm.DC_interact	5.07e-03	Nonsignificant	0.70	1.14	Other	72	32
517	EC.venous.activated	5.06e-03	Nonsignificant	0.79	0.97	Other	247	752
518	ADIPO.thermogenic	5.02e-03	Nonsignificant	—	0.29	Other	0	0
519	EPI.colonocyte.secretory_boost	5.01e-03	Nonsignificant	0.90	1.08	Other	98	91
520	EPI.ileal_goblet.immature	4.90e-03	Nonsignificant	—	0.73	Other	0	0
521	B.memory.pDC_imprint	4.83e-03	Nonsignificant	1.00	0.72	Other	157	103
522	T.CD4_naive.mature	4.47e-03	Nonsignificant	0.99	0.88	Other	211	100
523	T.CD4_naive.proteostasis	4.46e-03	Nonsignificant	0.99	0.96	Other	14	9
524	EPI.renal_immature_ureteric_bud.osmoprotective	4.44e-03	Nonsignificant	0.62	1.10	Other	126	44
525	EPI.colonocyte.junction_remodeling	4.28e-03	Nonsignificant	0.90	0.65	Other	218	305
526	MESO.antiviral	4.26e-03	Nonsignificant	—	0.00	Other	3	8
527	T.CD4_naive.resist_bystander	4.23e-03	Nonsignificant	0.99	0.96	Other	40	25
528	FIB.neurolectin_mucosa.remodeling_repair	4.23e-03	Nonsignificant	—	0.00	Other	4	2
529	EPI.ileal_goblet.inflammatory_mucin	4.22e-03	Nonsignificant	0.30	1.48	Other	6	9
530	T.CD4_Tem.cytotoxic_effector	4.17e-03	Nonsignificant	1.00	0.57	Other	225	398
531	EPI.salivary_myoepithelial.contractile_repair	4.14e-03	Nonsignificant	—	1.80	Other	3	9
532	PERI.cardiac_skeletal	4.12e-03	Nonsignificant	4.77e-03	1.18	Other	313	630
533	FIB.interstitial.immune_interact	4.09e-03	Nonsignificant	0.66	1.07	Other	12	1
534	EPI.ileal_enterocyte_crypt.baseline	4.07e-03	Nonsignificant	1.00	0.30	Other	11	6
535	FIB.adventitial.baseline	3.93e-03	Nonsignificant	0.98	1.01	Other	157	278
536	EC.capillary.stress	3.87e-03	Nonsignificant	0.99	0.75	Other	44	36
537	FIB.interstitial.remodeling	3.87e-03	Nonsignificant	0.84	1.00	Other	31	9
538	T.CD8_Tcm.effector_bias	3.73e-03	Nonsignificant	0.59	1.15	Other	199	329
539	B.memory.baseline	3.65e-03	Nonsignificant	1.00	0.45	Other	472	99
540	T.CD4_Tcm.crosstalk_myeloid	3.62e-03	Nonsignificant	0.87	1.01	Other	5	4
541	T.CD4_Tcm.Tfh_like	3.52e-03	Nonsignificant	0.77	1.09	Other	102	214
542	FIB.neurolectin_mucosa.inflammatory	3.50e-03	Nonsignificant	0.62	0.92	Other	52	110
543	EC.capillary.angiocrine	3.47e-03	Nonsignificant	0.99	0.71	Other	250	630
544	B.naive.antigen_presenting_ready	3.44e-03	Nonsignificant	0.99	0.97	Other	48	73
545	T.CD8_naive.effector_transition	3.42e-03	Nonsignificant	0.68	1.14	Other	35	62
546	B.naive.purinergic	3.37e-03	Nonsignificant	0.99	0.80	Other	384	820
547	T.CD4_Th2.precursor	3.28e-03	Nonsignificant	—	0.48	Other	0	0
548	EPI.skin_sweat_duct_keratinocyte.barrier	3.26e-03	Nonsignificant	—	0.00	Other	0	0
549	EC.arterial.inflammatory	3.21e-03	Nonsignificant	0.99	0.88	Other	63	50
550	T.CD4_Tcm.migratory_cilium	3.17e-03	Nonsignificant	0.77	1.10	Other	5	10
551	ASPC.activated	3.15e-03	Nonsignificant	0.88	0.87	Other	164	162
552	T.CD4_naive.homeostatic	3.13e-03	Nonsignificant	0.99	0.92	Other	215	108
553	T.CD4_Tcm.APC_mimicry	3.12e-03	Nonsignificant	0.93	0.96	Other	54	43
554	EPI.renal_thick_ascending_limb.salt_sensing	3.02e-03	Nonsignificant	1.00	0.00	Other	73	103
555	EPI.ileal_goblet.baseline	2.96e-03	Nonsignificant	0.87	0.50	Other	16	2
556	EPI.ileal_goblet.stress_metallothionein	2.88e-03	Nonsignificant	—	0.00	Other	4	11
557	EPI.renal_distal_tubule.ciliated_remodelling	2.83e-03	Nonsignificant	—	0.67	Other	0	0
558	T.MAIT.migratory	2.79e-03	Nonsignificant	0.86	1.28	Other	10	1
559	NK.cytokine_biosynthetic_primed	2.76e-03	Nonsignificant	1.00	1.00	Other	360	21
560	T.CD4_Tcm.regulatory_poised	2.73e-03	Nonsignificant	0.87	1.07	Other	2	3
561	EPI.colonocyte.goblet_interface	2.61e-03	Nonsignificant	—	0.00	Other	11	21
562	EPI.salivary_duct_ion_transport.baseline	2.56e-03	Nonsignificant	—	—	Other	0	0
563	EPI.ileal_enterocyte_absorptive.brush_border	2.40e-03	Nonsignificant	1.00	0.00	Other	580	1,717
564	T.gamma_delta.central_memory	2.39e-03	Nonsignificant	0.31	1.16	Other	460	919
565	ADIPO.hypoxia_remodelling	2.37e-03	Nonsignificant	—	0.00	Other	29	105
566	B.naive.remodeling	2.37e-03	Nonsignificant	0.99	0.83	Other	135	230
567	ADIPO.immature	2.35e-03	Nonsignificant	—	0.00	Other	24	40
568	T.CD8_naive.cytokine_dampened	2.34e-03	Nonsignificant	0.78	1.07	Other	71	4
569	T.CD4_Th17.baseline	2.27e-03	Nonsignificant	0.89	0.88	Other	51	5
570	T.CD4_Tcm.synapse_dynamics	2.26e-03	Nonsignificant	0.88	0.99	Other	15	10
571	T.CD4_naive.neddylation	2.26e-03	Nonsignificant	0.99	0.88	Other	104	222
572	CHOND.articular_collagen	2.24e-03	Nonsignificant	1.00	0.81	Other	551	266
573	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.22e-03	Nonsignificant	—	0.85	Other	0	0
574	T.CD4_naive.survival_neddylation	2.22e-03	Nonsignificant	0.99	0.89	Other	26	38
575	T.CD4_Treg.APC_interactive	2.18e-03	Nonsignificant	0.93	0.62	Other	118	28
576	MAC.LAM.lipid_phagocytosis	2.12e-03	Nonsignificant	0.98	0.68	Other	369	328
577	EPI.ileal_enterocyte_crypt.proliferative_S	2.09e-03	Nonsignificant	1.00	0.22	Other	4	2
578	T.CD8_Trm.cytotoxic	2.08e-03	Nonsignificant	0.95	0.83	Other	165	85
579	B.naive.receptor_recycle	2.08e-03	Nonsignificant	0.99	0.83	Other	51	0
580	EPI.skin_sweat_duct_keratinocyte.repair	2.03e-03	Nonsignificant	—	0.10	Other	0	0
581	T.CD4_Tcm.stress	1.99e-03	Nonsignificant	0.87	1.02	Other	5	11
582	T.CD8_naive.nfkb_related	1.92e-03	Nonsignificant	0.68	1.17	Other	1	0
583	T.CD4_Th17.migratory	1.92e-03	Nonsignificant	0.89	0.97	Other	13	23
584	NK.cytokine_quiescent	1.88e-03	Nonsignificant	1.00	1.02	Other	623	1,062
585	T.CD8_Tcm.helper_like	1.86e-03	Nonsignificant	0.82	0.95	Other	81	159
586	T.CD8_transitional.APC_like	1.80e-03	Nonsignificant	0.97	0.80	Other	205	62
587	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.76e-03	Nonsignificant	—	0.00	Other	43	26
588	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.75e-03	Nonsignificant	—	0.00	Other	29	88
589	EPI.renal_immature_ureteric_bud.defense_secretory	1.71e-03	Nonsignificant	0.78	0.86	Other	45	76
590	T.MAIT.MAPK_brake	1.71e-03	Nonsignificant	0.96	0.91	Other	44	66
591	T.CD4_naive.proteostasis_mitoprot	1.71e-03	Nonsignificant	0.99	0.85	Other	15	37
592	T.CD4_naive.mature_mitoprot	1.68e-03	Nonsignificant	0.99	0.82	Other	212	476
593	FIB.barrier_purinergic.stress_GF_binding	1.64e-03	Nonsignificant	—	0.00	Other	0	0
594	EPI.skin_appendage_keratinocyte.transit_amplifying	1.62e-03	Nonsignificant	—	0.00	Other	109	358
595	EPI.salivary_mucous_acinar.baseline	1.56e-03	Nonsignificant	—	—	Other	394	683
596	T.CD8_Tcm.NK_like	1.48e-03	Nonsignificant	0.82	1.02	Other	334	581
597	EPI.colonocyte.ionocyte_BEST4	1.46e-03	Nonsignificant	0.90	0.69	Other	103	188
598	EC.arterial.arteriole_gas_exchange	1.44e-03	Nonsignificant	0.99	0.71	Other	238	131
599	T.CD4_Tcm.imprinted_splicing	1.42e-03	Nonsignificant	0.87	1.02	Other	6	17
600	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.42e-03	Nonsignificant	0.92	0.65	Other	33	34
601	EC.capillary.migratory	1.41e-03	Nonsignificant	0.99	0.52	Other	181	509
602	ASPC.mesothelial_like	1.33e-03	Nonsignificant	0.85	1.01	Other	143	486
603	T.CD4_Treg.central_naive_like	1.31e-03	Nonsignificant	0.80	0.92	Other	333	45
604	T.CD8_naive.lipid_synthesis	1.27e-03	Nonsignificant	0.79	1.03	Other	6	4
605	T.CD8_Tem.TEMRA	1.26e-03	Nonsignificant	0.90	0.98	Other	920	1,088
606	EC.arterial.metabolic	1.24e-03	Nonsignificant	0.99	0.60	Other	195	159
607	EC.arterial.ion_pump	1.22e-03	Nonsignificant	0.99	0.73	Other	3	2
608	EC.heart_remodeling.activated_acute	1.16e-03	Nonsignificant	1.00	0.95	Other	102	186
609	EC.venous.remodeling_stalk	1.15e-03	Nonsignificant	0.96	0.68	Other	559	566
610	EC.arterial.angiogenic_tip	1.14e-03	Nonsignificant	—	0.22	Other	30	37
611	EPI.renal_principal_cell.canonical_vasopressin	1.11e-03	Nonsignificant	0.41	1.37	Other	2	0
612	T.gamma_delta.cytotoxic_effector	1.10e-03	Nonsignificant	0.77	0.90	Other	349	109
613	T.gamma_delta.early_effector	1.08e-03	Nonsignificant	0.77	0.96	Other	89	0
614	EC.heart_remodeling.remodeling_stalk	1.06e-03	Nonsignificant	1.00	0.84	Other	33	111
615	FIB.adventitial.mechano_chemo_sensing	1.02e-03	Nonsignificant	0.98	0.80	Other	135	524
616	T.CD4_Th2.tissue_adapted	1.02e-03	Nonsignificant	—	0.00	Other	0	0
617	EPI.lung_multiciliated.baseline	1.01e-03	Nonsignificant	—	0.51	Other	0	7
618	NK.adaptive_immature_precursor	1.01e-03	Nonsignificant	1.00	0.95	Other	358	111
619	T.CD4_cytotoxic.NK_adapted	1.00e-03	Nonsignificant	0.72	1.09	Other	82	33
620	FIB.adventitial.mito_secretory	9.96e-04	Nonsignificant	0.98	0.88	Other	21	7
621	EPI.salivary_serous_acinar.seromucous_like	9.65e-04	Nonsignificant	—	0.00	Other	0	0
622	T.CD8_Tem.stress_adapted	9.65e-04	Nonsignificant	0.91	0.92	Other	607	520
623	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	8.79e-04	Nonsignificant	—	0.00	Other	0	0
624	FIB.adventitial.complement_angiocrine	8.19e-04	Nonsignificant	0.98	0.77	Other	153	684
625	T.CD4_cytotoxic.activated	8.15e-04	Nonsignificant	0.72	0.95	Other	3	1
626	EC.arterial.mito_contact	7.95e-04	Nonsignificant	0.99	0.74	Other	14	5
627	B.naive.proteostasis	7.80e-04	Nonsignificant	0.99	0.52	Other	49	69
628	NK.cytokine_repair_primed	7.74e-04	Nonsignificant	1.00	1.02	Other	266	11
629	FIB.adventitial.PI16_matrix	7.65e-04	Nonsignificant	0.98	0.84	Other	70	90
630	T.CD4_Tcm.baseline	7.54e-04	Nonsignificant	0.93	0.92	Other	61	31
631	T.CD4_cytotoxic.terminal_effector	7.45e-04	Nonsignificant	0.72	0.91	Other	286	21
632	FIB.skin_papillary.baseline	7.33e-04	Nonsignificant	—	0.00	Other	0	0
633	T.CD4_cytotoxic.baseline	7.32e-04	Nonsignificant	0.72	0.97	Other	0	0
634	T.CD8_transitional.stress	7.27e-04	Nonsignificant	—	0.21	Other	24	34
635	NK.cytokine_axis_baseline	6.98e-04	Nonsignificant	1.00	0.90	Other	1,172	116
636	NK.adaptive_HLAE_tuned	6.75e-04	Nonsignificant	1.00	0.93	Other	1,124	189
637	EPI.skin_sebaceous_duct_luminal.detox_repair	6.74e-04	Nonsignificant	0.69	0.90	Other	137	94
638	T.MAIT.quiescent	6.44e-04	Nonsignificant	0.96	0.63	Other	100	5
639	CHOND.activated_fibro_like	6.36e-04	Nonsignificant	1.00	0.38	Other	531	188
640	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	5.70e-04	Nonsignificant	0.69	1.13	Other	2	9
641	T.CD4_naive.purinergic	5.63e-04	Nonsignificant	0.99	0.80	Other	49	1
642	T.CD8_naive.baseline	5.56e-04	Nonsignificant	0.95	0.77	Other	142	2
643	EPI.salivary_myoepithelial.baseline	5.36e-04	Nonsignificant	0.90	1.03	Other	42	141
644	FIB.interstitial.mesenchymal_APC	5.10e-04	Nonsignificant	1.00	0.40	Other	81	33
645	T.MAIT.vesicle	4.91e-04	Nonsignificant	0.96	0.40	Other	37	65
646	EPI.renal_distal_tubule.repair	4.32e-04	Nonsignificant	—	0.04	Other	34	102
647	EPI.renal_principal_cell.intercalated_like	4.26e-04	Nonsignificant	0.62	1.11	Other	63	66
648	T.CD4_naive.survival	3.95e-04	Nonsignificant	0.99	0.75	Other	12	17
649	T.MAIT.cytotoxic	3.88e-04	Nonsignificant	0.96	0.42	Other	52	15
650	EC.heart_remodeling.capillary_metabolic	3.83e-04	Nonsignificant	1.00	0.87	Other	54	414
651	NK.cytokine_vascular_patrolling	3.59e-04	Nonsignificant	1.00	0.89	Other	863	94
652	EPI.alveolar_type_2.injury_primed	3.53e-04	Nonsignificant	0.71	1.01	Other	434	245
653	EC.heart_remodeling.remodeling_secretory	3.28e-04	Nonsignificant	1.00	0.62	Other	605	1,341
654	NK.adaptive_classII_inhibitory	3.08e-04	Nonsignificant	1.00	0.89	Other	880	154
655	EPI.renal_principal_cell.activated_acute	2.43e-04	Nonsignificant	0.81	0.77	Other	29	59
656	T.CD4_Tcm.secretory	2.39e-04	Nonsignificant	0.93	0.91	Other	20	11
657	T.CD8_naive.innate_like	2.26e-04	Nonsignificant	0.95	0.73	Other	10	1
658	T.CD4_Tcm.retro_ZNF117	2.15e-04	Nonsignificant	1.00	0.73	Other	5	9
659	SKM.type_2_fast.glycolytic_IIx_IIb	2.01e-04	Nonsignificant	0.99	0.56	Other	565	1,482
660	EPI.salivary_myoepithelial.activated	1.97e-04	Nonsignificant	0.90	0.77	Other	85	281
661	T.CD8_naive.mito_proteostasis	1.90e-04	Nonsignificant	0.95	0.74	Other	428	100
662	EPI.renal_principal_cell.inflammatory	1.82e-04	Nonsignificant	0.62	1.14	Other	74	157
663	EPI.lung_multiciliated.stress	1.48e-04	Nonsignificant	—	0.00	Other	67	165
664	EC.heart_remodeling.perivascular	1.39e-04	Nonsignificant	1.00	0.86	Other	124	408
665	T.CD4_Tcm.RNA_control	1.33e-04	Nonsignificant	1.00	0.62	Other	96	4
666	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.24e-04	Nonsignificant	—	0.00	Other	0	0
667	EPI.renal_principal_cell.injury_repair	1.16e-04	Nonsignificant	0.81	0.82	Other	26	9
668	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.11e-04	Nonsignificant	—	0.00	Other	0	0
669	T.MAIT.stress	1.07e-04	Nonsignificant	—	0.00	Other	0	0
670	T.CD8_Tcm.gut_homing	1.07e-04	Nonsignificant	0.98	0.62	Other	380	112
671	T.CD8_Tem.motility_primed	1.07e-04	Nonsignificant	0.86	1.02	Other	269	4
672	NK.cytokine_tissue_activation	9.77e-05	Nonsignificant	1.00	0.85	Other	267	450
673	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	9.60e-05	Nonsignificant	—	0.00	Other	0	0
674	FIB.interstitial.stress_secretory	8.62e-05	Nonsignificant	1.00	0.10	Other	92	56
675	FIB.adventitial.activated_remodelling	8.39e-05	Nonsignificant	—	0.00	Other	141	319
676	MAC.LAM.perivascular_angiocrine	8.32e-05	Nonsignificant	—	0.00	Other	53	138
677	ASPC.signal_integrator	8.27e-05	Nonsignificant	—	0.00	Other	0	0
678	EPI.salivary_myoepithelial.junctional_transport	7.31e-05	Nonsignificant	0.90	0.70	Other	66	121
679	NK.adaptive_terminal_cytotoxic	6.55e-05	Nonsignificant	1.00	0.77	Other	485	802
680	EPI.skin_sweat_duct_keratinocyte.proliferative_S	3.22e-05	Nonsignificant	—	0.00	Other	0	0
681	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	2.77e-05	Nonsignificant	—	0.00	Other	39	82
682	EPI.alveolar_type_2.stress_response	1.95e-05	Nonsignificant	1.00	0.59	Other	675	1,562
683	NK.adaptive_adipose_stress	1.44e-05	Nonsignificant	1.00	0.66	Other	374	39
684	NK.adaptive_biosynthetic_primed	9.48e-06	Nonsignificant	1.00	0.83	Other	244	405
685	EPI.lung_club_secretory.ciliogenesis_axoneme	6.41e-06	Nonsignificant	—	0.00	Other	0	0
686	EPI.renal_distal_tubule.ion_transport	6.25e-06	Nonsignificant	—	0.00	Other	0	0
687	EPI.skin_sebaceous_duct_luminal.immune_interface	1.12e-06	Nonsignificant	—	0.00	Other	0	0
688	EPI.renal_distal_tubule.stress	1.88e-07	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

11 unique genes. Showing 1–11. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ADH1B	02-Medium	0.54	7.34	G1	C2	FIB.neurolectin_mucosa.remodeling_repair (L2), FIB.suburothelial.homeostasis_matrix (L2), HEP.periportal_metabolic.xenobiotic_detox (L2)	—	73 cells — complete matches	99	251
ADH1A	02-Medium	0.53	7.56	G1	C2	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2)	—	15 cells — complete matches	131	299
ENSG00000299292	02-Medium	0.52	8.34	G1	C2	—	—	—	130	304
ADH1C	02-Medium	0.49	6.93	G1	C2	EPI.bile_duct_cholangiocyte.secretory_mucin (L2), EPI.ileal_bile_transport.detox_transcytosis (L2), EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2), EPI.salivary_intercalated_defense.basal_EMT (L2), EPI.salivary_myoepithelial.baseline (L2), EPI.tracheal_suprabasal.secretory_immune (L2)	—	54 cells — complete matches	133	303
ENSG00000299279	02-Medium	0.48	6.60	G1	C2	—	—	—	134	304
ADH6	02-Medium	0.46	6.12	G1	C2	EPI.colonic_enteroendocrine.enterochromaffin_serotonin (L2)	—	14 cells — complete matches	130	298
ENSG00000246090	02-Medium	0.41	3.80	G1	C2	—	—	—	103	272
PDE4B-AS1	02-Medium	0.40	6.43	G2	C1	—	—	—	2	0
RAB27B	02-Medium	0.40	8.00	G2	C1	PLAT.megakaryocytic (L2)	oligodendrocyte_precursor_cell (Tier: specific) OPC.oligodendrocyte_precursor_cell (Tier: specific) platelet (Tier: relevant) PLAT.platelet (Tier: relevant) OPC.proliferative_immune_interact (Tier: relevant) PLAT.adhesion (Tier: relevant)	67 cells — complete matches	11	32
ENSG00000303535	02-Medium	0.30	5.51	G2	C1	—	—	—	11	32
PDE4B	02-Medium	0.28	5.27	G2	C1	IPSC.mesendo_primed (L2)	EPI.pancreatic_islet.beta (Tier: relevant)	67 cells — complete matches	5	3

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.