Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000042 · All tissues

Adenomyosis (Endometriosis of uterus): evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Endometriosis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	hepatocyte	29.95	Significant	3.10e-48	1.31	Specific	1,515	3,822
2	adipocyte	26.59	Significant	0.44	1.20	Relevant	33	111
3	skeletal_muscle_cell	10.80	Significant	5.49e-09	1.22	Specific	944	2,600
4	astrocyte	9.48	Significant	0.07	1.10	Relevant	256	1,203
5	mesothelial_cell	6.93	Significant	1.00	1.01	Relevant	6	36
6	chondrocyte	6.16	Significant	0.47	1.07	Relevant	548	1,069
7	oligodendrocyte	5.21	Nominal	1.78e-07	1.13	Other	385	1,507
8	fibroblast	3.72	Nominal	1.00	0.95	Other	184	826
9	endothelial_cell	3.64	Nominal	1.00	0.97	Other	373	974
10	natural_killer_cell	2.74	Nonsignificant	0.81	1.02	Other	1,204	2,052
11	induced_pluripotent_stem_cell	2.44	Nonsignificant	1.00	0.95	Other	0	0
12	oligodendrocyte_precursor_cell	1.48	Nonsignificant	1.00	0.89	Other	461	1,454
13	granulosa_cell	1.38	Nonsignificant	1.00	0.87	Other	293	670
14	smooth_muscle_cell	1.25	Nonsignificant	1.00	0.79	Other	27	139
15	schwann_cell	1.07	Nonsignificant	1.00	0.87	Other	10	57
16	microglia	0.82	Nonsignificant	1.00	0.83	Other	61	129
17	muscle_stem_cell	0.75	Nonsignificant	1.00	0.79	Other	7	27
18	melanocyte	0.67	Nonsignificant	1.00	0.79	Other	97	309
19	haematopoietic_progenitor_cell	0.57	Nonsignificant	1.00	0.84	Other	262	502
20	neuron	0.48	Nonsignificant	1.00	0.75	Other	330	1,328
21	T_cell	0.43	Nonsignificant	1.00	0.79	Other	470	959
22	platelet	0.33	Nonsignificant	—	0.00	Other	85	104
23	adipose_stem_and_progenitor_cell	0.32	Nonsignificant	1.00	0.69	Other	327	954
24	plasma_cell	0.31	Nonsignificant	1.00	0.72	Other	17	24
25	pericyte	0.29	Nonsignificant	1.00	0.73	Other	128	517
26	macrophage	0.27	Nonsignificant	1.00	0.78	Other	813	1,732
27	epithelial_cell	0.24	Nonsignificant	1.00	0.75	Other	24	47
28	thymocyte	0.12	Nonsignificant	1.00	0.76	Other	168	512
29	granulocyte	0.06	Nonsignificant	1.00	0.61	Other	5	6
30	innate_lymphoid_cell_2	0.03	Nonsignificant	1.00	0.56	Other	3	8
31	cardiomyocyte	0.02	Nonsignificant	1.00	0.54	Other	533	2,045
32	dendritic_cell	9.34e-03	Nonsignificant	1.00	0.49	Other	496	724
33	B_cell	8.98e-03	Nonsignificant	1.00	0.46	Other	356	694
34	monocyte	2.25e-03	Nonsignificant	1.00	0.41	Other	2,176	3,871

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HEP.periportal_metabolic	53.67	Significant	3.00e-50	2.69	Specific	1,750	4,427
2	ADIPO.adipocyte	26.59	Significant	—	—	Relevant	20	62
3	HEP.acute_phase	18.53	Significant	1.00	0.44	Specific	1,441	3,641
4	EC.heart_remodeling	15.85	Significant	1.49e-28	1.60	Specific	569	1,594
5	HEP.canalicular_transport	14.48	Significant	1.00	0.01	Specific	1,290	3,434
6	FIB.transitioning	11.46	Significant	4.29e-04	1.72	Specific	172	497
7	SKM.type_2_fast	11.33	Significant	1.23e-07	2.91	Specific	972	2,639
8	SKM.type_1_slow	10.08	Significant	0.91	0.55	Specific	923	2,478
9	ASTRO.astrocyte	9.48	Significant	—	—	Relevant	228	1,111
10	EC.liver_sinusoidal	8.15	Significant	0.07	1.21	Relevant	1,083	1,925
11	MESO.mesothelial_cell	6.93	Significant	—	—	Relevant	2	18
12	CHOND.chondrocyte	6.16	Significant	—	—	Relevant	519	730
13	FIB.adventitial	6.11	Significant	4.66e-47	2.12	Specific	268	1,447
14	OLG.oligodendrocyte	5.21	Nominal	—	—	Other	384	1,397
15	EC.lymphatic	4.52	Nominal	0.83	1.00	Other	630	998
16	FIB.reticular	3.90	Nominal	1.00	0.92	Other	19	87
17	T.CD8_Tem	3.57	Nominal	2.73e-17	1.16	Other	1,083	1,857
18	EC.arterial	2.92	Nonsignificant	0.29	1.06	Other	356	885
19	HEP.pericentral_lipoprotein	2.78	Nonsignificant	—	0.00	Other	0	0
20	NK.natural_killer_cell	2.74	Nonsignificant	—	—	Other	1,204	2,045
21	EPI.thymic_medullary	2.55	Nonsignificant	0.41	1.14	Other	26	133
22	FIB.tracheal_subepithelial	2.52	Nonsignificant	—	0.01	Other	0	0
23	IPSC.induced_pluripotent_stem_cell	2.44	Nonsignificant	—	—	Other	0	0
24	FIB.neurolectin_mucosa	2.00	Nonsignificant	1.00	0.74	Other	133	394
25	FIB.hepatic_stellate_cell	1.63	Nonsignificant	—	0.00	Other	64	252
26	NEU.INH_VIP	1.63	Nonsignificant	2.39e-07	1.60	Other	241	366
27	FIB.perivascular_interface	1.57	Nonsignificant	1.00	0.67	Other	0	0
28	EPI.pancreatic_islet	1.53	Nonsignificant	1.00	1.14	Other	52	132
29	OPC.oligodendrocyte_precursor_cell	1.48	Nonsignificant	—	—	Other	413	1,269
30	GRNLSA.granulosa_cell	1.38	Nonsignificant	—	—	Other	257	0
31	SMC.smooth_muscle_cell	1.25	Nonsignificant	—	—	Other	20	101
32	EPI.hepatic_ductular_cholangiocyte	1.23	Nonsignificant	1.00	1.02	Other	83	243
33	MAC.resident_cardiac	1.08	Nonsignificant	2.75e-07	1.23	Other	485	1,074
34	SCHWN.schwann_cell	1.07	Nonsignificant	—	—	Other	7	33
35	EPI.alveolar_type_2	1.07	Nonsignificant	0.41	1.08	Other	813	1,853
36	FIB.skin_tenogenic	1.04	Nonsignificant	—	0.00	Other	108	227
37	EC.venous	1.04	Nonsignificant	1.00	0.47	Other	516	1,387
38	EPI.pancreatic_acinar	0.95	Nonsignificant	0.12	1.09	Other	429	1,475
39	EC.capillary	0.91	Nonsignificant	1.00	0.39	Other	514	1,635
40	FIB.interstitial	0.89	Nonsignificant	1.00	0.03	Other	288	940
41	EPI.tracheal_submucosal_gland	0.84	Nonsignificant	—	1.01	Other	0	0
42	T.CD4_cytotoxic	0.83	Nonsignificant	1.00	0.99	Other	855	1,493
43	FIB.skin_sheath	0.82	Nonsignificant	1.00	0.31	Other	49	118
44	MG.microglia	0.82	Nonsignificant	—	—	Other	49	0
45	EPI.skin_hair_follicle_companion	0.81	Nonsignificant	—	1.24	Other	8	12
46	FIB.barrier_secretory	0.78	Nonsignificant	1.00	0.24	Other	81	228
47	MUSC.muscle_stem_cell	0.75	Nonsignificant	—	—	Other	4	18
48	FIB.skin_papillary	0.74	Nonsignificant	—	0.00	Other	0	0
49	T.CD8_transitional	0.73	Nonsignificant	0.75	1.02	Other	497	932
50	NEU.EXC_SYT2	0.67	Nonsignificant	—	0.54	Other	40	77
51	MEL.melanocyte	0.67	Nonsignificant	—	—	Other	79	242
52	MAC.kupffer	0.64	Nonsignificant	1.00	0.98	Other	189	530
53	EPI.intrahepatic_cholangiocyte_transport	0.59	Nonsignificant	—	0.71	Other	12	42
54	NEU.EXC_NTNG1	0.58	Nonsignificant	—	0.72	Other	0	0
55	FIB.lung_alveolar	0.57	Nonsignificant	—	0.00	Other	6	15
56	HPC.haematopoietic_progenitor_cell	0.57	Nonsignificant	—	—	Other	211	370
57	FIB.skin_neurosecretory	0.54	Nonsignificant	—	0.00	Other	0	0
58	PC.IgG_systemic	0.43	Nonsignificant	0.17	1.31	Other	41	60
59	FIB.barrier_purinergic	0.42	Nonsignificant	—	0.00	Other	1	3
60	FIB.suburothelial	0.42	Nonsignificant	1.00	0.04	Other	122	432
61	EPI.skin_appendage_keratinocyte	0.39	Nonsignificant	1.00	0.97	Other	87	222
62	PLAT.platelet	0.33	Nonsignificant	—	0.00	Other	38	53
63	ASPC.adipose_stem_and_progenitor_cell	0.32	Nonsignificant	—	—	Other	324	930
64	MAC.microglia_like	0.32	Nonsignificant	1.00	0.91	Other	124	179
65	NEU.INH_LAMP5	0.31	Nonsignificant	1.00	0.65	Other	263	532
66	PC.IgA_muocsal	0.30	Nonsignificant	0.98	0.57	Other	18	31
67	EPI.extrahepatic_cholangiocyte	0.29	Nonsignificant	—	0.68	Other	37	71
68	PERI.pericyte	0.29	Nonsignificant	—	—	Other	117	0
69	NEU.EXC_IT	0.29	Nonsignificant	1.00	0.69	Other	411	192
70	EPI.cervical_suprabasal	0.24	Nonsignificant	—	0.39	Other	14	50
71	T.gamma_delta	0.16	Nonsignificant	1.00	0.91	Other	588	1,078
72	EPI.pancreatic_ductal_bicarbonate	0.15	Nonsignificant	0.15	1.11	Other	131	548
73	T.CD4_Tem	0.14	Nonsignificant	1.00	0.94	Other	365	697
74	MAC.MDM	0.13	Nonsignificant	1.00	0.95	Other	623	986
75	MAC.resident_iron	0.13	Nonsignificant	1.00	0.89	Other	16	21
76	THYMO.thymocyte	0.12	Nonsignificant	—	—	Other	163	495
77	GRANU.MAST	0.09	Nonsignificant	4.69e-04	1.50	Other	5	6
78	MAC.alveolar	0.09	Nonsignificant	1.00	0.87	Other	1,432	3,122
79	EPI.ectocervical_granular	0.08	Nonsignificant	—	0.21	Other	11	23
80	EPI.alveolar_type_1	0.08	Nonsignificant	1.00	0.89	Other	26	101
81	T.CD4_Tfh	0.08	Nonsignificant	1.00	0.89	Other	47	45
82	NEU.EXC_CT	0.07	Nonsignificant	1.00	0.33	Other	362	384
83	EPI.esophageal_basal	0.07	Nonsignificant	1.00	0.95	Other	4	10
84	T.CD4_Th17	0.06	Nonsignificant	1.00	0.83	Other	421	794
85	MAC.resident_repair	0.06	Nonsignificant	1.00	0.92	Other	796	1,426
86	EPI.tracheal_suprabasal	0.06	Nonsignificant	1.00	1.10	Other	29	56
87	EPI.renal_intercalated_cell_type_A	0.06	Nonsignificant	1.00	0.82	Other	67	142
88	EPI.skin_keratinocyte_basal	0.06	Nonsignificant	—	0.39	Other	13	26
89	T.CD4_Trm	0.04	Nonsignificant	1.00	0.82	Other	176	363
90	EPI.colonocyte	0.04	Nonsignificant	1.00	0.79	Other	294	815
91	EPI.thymic_cortical	0.04	Nonsignificant	1.00	1.06	Other	442	824
92	EPI.gastric_foveolar	0.04	Nonsignificant	—	0.69	Other	0	0
93	EPI.renal_intercalated_cell_type_B	0.03	Nonsignificant	—	0.62	Other	6	7
94	EPI.colonic_enteroendocrine	0.03	Nonsignificant	—	0.34	Other	1	1
95	T.CD8_naive	0.03	Nonsignificant	1.00	0.68	Other	317	708
96	EPI.skin_follicular_keratinizing	0.03	Nonsignificant	1.00	0.78	Other	30	81
97	T.CD4_naive	0.03	Nonsignificant	1.00	0.66	Other	399	866
98	ILC2.innate_lymphoid_cell_2	0.03	Nonsignificant	—	—	Other	2	0
99	EPI.renal_thick_ascending_limb	0.02	Nonsignificant	1.00	1.00	Other	453	1,153
100	MAC.LAM	0.02	Nonsignificant	1.00	0.85	Other	914	2,064
101	T.CD4_Th2	0.02	Nonsignificant	—	0.06	Other	1	2
102	EPI.ileal_enterocyte_absorptive	0.02	Nonsignificant	1.00	0.74	Other	118	338
103	T.CD4_Tcm	0.02	Nonsignificant	1.00	0.73	Other	494	988
104	CM.cardiomyocyte	0.02	Nonsignificant	—	—	Other	524	2,032
105	EPI.ileal_enterocyte_crypt	0.02	Nonsignificant	1.00	0.72	Other	67	113
106	B.germinal_center	0.02	Nonsignificant	0.58	1.13	Other	233	655
107	EPI.pancreatic_ductal_perivascular	0.01	Nonsignificant	1.00	0.79	Other	4	30
108	T.CD4_transitional	0.01	Nonsignificant	1.00	0.66	Other	48	110
109	EPI.skin_interfollicular_spinous	0.01	Nonsignificant	1.00	0.92	Other	260	563
110	EPI.lung_club_secretory	0.01	Nonsignificant	1.00	0.83	Other	5	14
111	B.memory	0.01	Nonsignificant	0.58	1.03	Other	442	882
112	DC.cDC2	0.01	Nonsignificant	0.52	1.07	Other	1,189	1,793
113	DC.cDC1	0.01	Nonsignificant	0.63	1.05	Other	55	112
114	EPI.colonic_tuft	0.01	Nonsignificant	—	0.31	Other	7	24
115	EPI.intrahepatic_cholangiocyte_defense	0.01	Nonsignificant	—	0.12	Other	8	13
116	EPI.ileal_goblet	0.01	Nonsignificant	1.00	0.71	Other	181	432
117	T.CD8_Trm	9.76e-03	Nonsignificant	1.00	0.59	Other	211	346
118	T.MAIT	9.53e-03	Nonsignificant	1.00	0.49	Other	469	855
119	EPI.skin_keratinocyte_progenitor	9.01e-03	Nonsignificant	—	0.27	Other	0	3
120	EPI.renal_immature_ureteric_bud	7.43e-03	Nonsignificant	1.00	0.76	Other	217	569
121	EPI.tracheal_basal	7.11e-03	Nonsignificant	1.00	0.58	Other	398	1,120
122	EPI.pancreatic_ductal_progenitor	6.79e-03	Nonsignificant	1.00	0.56	Other	234	873
123	EPI.salivary_duct_excretory	6.65e-03	Nonsignificant	1.00	0.63	Other	85	180
124	MONO.CD16	6.42e-03	Nonsignificant	7.14e-03	1.06	Other	1,304	1,835
125	B.naive	6.19e-03	Nonsignificant	0.83	0.97	Other	307	595
126	EPI.skin_hair_follicle_bulge	6.07e-03	Nonsignificant	1.00	0.60	Other	51	178
127	EPI.skin_sweat_duct_keratinocyte	5.30e-03	Nonsignificant	1.00	0.63	Other	146	301
128	EPI.skin_sebaceous_duct_luminal	5.20e-03	Nonsignificant	1.00	0.59	Other	100	249
129	EPI.ileal_bile_transport	5.13e-03	Nonsignificant	1.00	0.58	Other	61	93
130	EPI.renal_principal_cell	4.82e-03	Nonsignificant	1.00	0.58	Other	207	403
131	EPI.lung_multiciliated	4.68e-03	Nonsignificant	1.00	0.67	Other	16	49
132	EPI.renal_proximal_tubule	4.59e-03	Nonsignificant	1.00	0.57	Other	525	806
133	B.age_associated	4.47e-03	Nonsignificant	0.58	1.05	Other	207	350
134	EPI.salivary_intercalated_defense	3.36e-03	Nonsignificant	1.00	0.76	Other	81	161
135	T.CD4_Treg	3.02e-03	Nonsignificant	1.00	0.67	Other	244	511
136	T.CD8_Tcm	2.22e-03	Nonsignificant	1.00	0.41	Other	460	926
137	EPI.salivary_duct_ion_transport	2.09e-03	Nonsignificant	1.00	0.51	Other	5	11
138	EPI.esophageal_suprabasal	2.00e-03	Nonsignificant	1.00	0.41	Other	158	404
139	EPI.salivary_serous_acinar	1.92e-03	Nonsignificant	1.00	0.66	Other	233	531
140	NEU.INH_PVALB	1.83e-03	Nonsignificant	1.00	8.07e-03	Other	193	183
141	MONO.CD14	1.44e-03	Nonsignificant	0.92	0.97	Other	2,294	4,139
142	EPI.salivary_myoepithelial	1.32e-03	Nonsignificant	1.00	0.37	Other	191	714
143	EPI.endocervical_secretory	1.16e-03	Nonsignificant	—	0.00	Other	0	0
144	DC.mig	1.10e-03	Nonsignificant	—	0.15	Other	89	156
145	EPI.bile_duct_cholangiocyte	9.41e-04	Nonsignificant	1.00	0.42	Other	37	60
146	GRANU.neutrophil	6.77e-04	Nonsignificant	1.00	0.00	Other	1,235	2,649
147	EPI.pancreatic_ductal_mucinous	6.02e-04	Nonsignificant	1.00	0.58	Other	219	430
148	MAC.proliferating	4.09e-04	Nonsignificant	1.00	0.71	Other	87	253
149	EPI.skin_keratinocyte_proliferating	3.08e-04	Nonsignificant	1.00	0.27	Other	47	76
150	EPI.renal_distal_tubule	2.12e-04	Nonsignificant	1.00	0.58	Other	133	361
151	EPI.salivary_mucous_acinar	1.38e-04	Nonsignificant	1.00	0.35	Other	639	1,189
152	DC.pDC	1.76e-07	Nonsignificant	1.00	0.16	Other	496	1,028

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HEP.periportal_metabolic.acute_phase_barrier	63.34	Significant	0.06	1.83	—	533	138
2	HEP.periportal_metabolic.xenobiotic_detox	61.44	Significant	0.06	1.67	—	1,440	139
3	HEP.periportal_metabolic.canonical_urea_cycle	56.07	Significant	0.71	0.98	—	1,464	269
4	HEP.periportal_metabolic.urea_onecarbon_secretory	55.81	Significant	0.71	1.05	Specific	1,332	3,053
5	HEP.periportal_metabolic.stress_checkpoint	50.64	Significant	0.06	1.70	Relevant	234	786
6	HEP.periportal_metabolic.stress_chaperone	49.25	Significant	—	0.00	Relevant	66	128
7	HEP.periportal_metabolic.apolipoprotein_secretory	42.45	Significant	0.80	0.80	Relevant	43	110
8	ADIPO.inflammatory	38.84	Significant	—	0.59	Relevant	0	0
9	ADIPO.immature	37.31	Significant	—	0.63	—	24	40
10	HEP.periportal_metabolic.inflammatory_activated	33.43	Significant	1.00	0.11	Relevant	712	1,610
11	ADIPO.hypoxia_remodelling	24.51	Significant	—	0.03	Relevant	29	105
12	HEP.acute_phase.complement_metabolic	23.71	Significant	1.01e-06	2.68	Specific	1,423	3,464
13	EC.heart_remodeling.perivascular	19.41	Significant	0.07	1.87	Relevant	124	408
14	EC.heart_remodeling.activated_acute	18.69	Significant	0.22	1.65	Relevant	102	186
15	ASPC.signal_integrator	18.69	Significant	—	2.77	Relevant	0	0
16	HEP.canalicular_transport.inflammatory	18.24	Significant	6.11e-06	2.22	—	1,335	194
17	ASTRO.stress_mito	17.96	Significant	0.08	1.56	—	47	110
18	HEP.canalicular_transport.baseline	17.67	Significant	0.41	1.38	Relevant	199	477
19	FIB.adventitial.activated_remodelling	17.60	Significant	—	2.03	Specific	141	319
20	HEP.acute_phase.proliferative	17.56	Significant	—	0.00	Relevant	4	6
21	HEP.canalicular_transport.sterol_lipid_biosynthesis	17.52	Significant	—	0.59	Relevant	10	20
22	HEP.acute_phase.complement_antiviral	17.48	Significant	1.00	0.98	Relevant	377	751
23	HEP.acute_phase.hypoxia_lipid	17.39	Significant	—	0.00	Relevant	0	0
24	HEP.acute_phase.inflammatory	17.37	Significant	1.00	0.52	Relevant	382	649
25	EC.heart_remodeling.remodeling_stalk	17.12	Significant	0.52	1.10	Relevant	33	111
26	EC.heart_remodeling.remodeling_secretory	16.75	Significant	0.30	1.38	Relevant	605	1,341
27	HEP.canalicular_transport.pericentral_like_hypoxia	16.07	Significant	0.63	1.14	—	326	8
28	ASTRO.homeostatic	16.05	Significant	0.02	1.61	—	200	431
29	HEP.acute_phase.baseline	15.74	Significant	1.00	0.20	—	946	19
30	FIB.transitioning.ISG_primed_interface	15.61	Significant	—	0.97	Relevant	17	80
31	EC.heart_remodeling.capillary_metabolic	14.15	Significant	0.52	1.10	Relevant	54	414
32	MESO.activated_stress	13.24	Significant	—	0.67	Relevant	0	0
33	EC.heart_remodeling.angiocrine	12.53	Significant	1.00	0.12	Relevant	182	525
34	SKM.type_2_fast.oxidative_IIa	12.36	Significant	7.12e-06	2.81	—	946	56
35	HEP.acute_phase.stress_secretory	12.13	Significant	1.00	0.09	—	26	3
36	ASTRO.synaptic_interaction	11.93	Significant	0.41	1.23	Relevant	76	334
37	ASTRO.immature_lipid	11.22	Significant	1.00	1.02	Relevant	23	113
38	HEP.canalicular_transport.secretory_ERAD_UPR	11.20	Significant	1.00	0.28	—	232	28
39	FIB.transitioning.matrix_stress	10.83	Significant	—	0.00	Relevant	47	138
40	SKM.type_1_slow.glycolytic	10.76	Significant	0.05	1.85	Relevant	362	647
41	EC.liver_sinusoidal.stress	10.73	Significant	—	0.94	—	413	158
42	EC.heart_remodeling.translation_boost	10.63	Significant	—	0.00	—	0	0
43	FIB.transitioning.secretory_procollagen	10.63	Significant	—	5.55e-17	Relevant	0	0
44	SKM.type_1_slow.oxidative	10.63	Significant	0.04	1.98	—	802	251
45	ASPC.mesothelial_like	10.28	Significant	4.64e-03	1.63	Specific	143	486
46	EC.liver_sinusoidal.inflammatory	10.24	Significant	—	0.62	—	223	154
47	HEP.canalicular_transport.injury_stress	10.19	Significant	1.00	0.22	—	289	24
48	SKM.type_2_fast.glycolytic_IIx_IIb	9.59	Significant	0.99	0.23	Relevant	565	1,482
49	EC.liver_sinusoidal.secretory_lipoprotein	9.52	Significant	0.31	1.47	—	120	70
50	HEP.canalicular_transport.ductular_like_transition	9.51	Significant	1.00	0.31	—	400	87
51	SKM.type_1_slow.contractile	9.33	Significant	0.87	0.47	—	596	8
52	ASTRO.A2_reactive	8.78	Significant	1.00	0.67	Relevant	10	37
53	EC.liver_sinusoidal.prostanoid	8.09	Significant	—	0.00	Relevant	11	64
54	ADIPO.thermogenic	8.00	Significant	—	0.00	—	0	0
55	CHOND.activated_fibro_like	7.72	Significant	9.64e-04	2.06	—	531	188
56	MESO.antiviral	7.29	Significant	—	0.41	—	3	8
57	FIB.adventitial.baseline	7.22	Significant	0.11	1.65	Relevant	157	278
58	ASTRO.hypoxia_angiogenic	7.01	Significant	1.00	0.77	Relevant	5	18
59	EC.liver_sinusoidal.remodeling_lipotoxicity	6.94	Significant	—	0.00	—	90	58
60	EC.lymphatic.scavenger	6.92	Significant	0.20	1.42	Relevant	203	257
61	FIB.reticular.stress_metallothionein	6.90	Significant	—	0.74	Relevant	3	32
62	FIB.adventitial.mechano_chemo_sensing	6.89	Significant	0.56	1.27	Relevant	135	524
63	MESO.activated_migratory	6.83	Significant	—	0.28	—	0	0
64	FIB.adventitial.mito_secretory	6.78	Significant	0.56	1.28	—	21	7
65	IPSC.mesendo_primed	6.48	Significant	5.31e-10	1.42	Relevant	0	0
66	FIB.adventitial.PI16_matrix	6.45	Significant	0.95	0.97	Relevant	70	90
67	IPSC.mesodermal_primed	6.33	Significant	0.15	1.23	Relevant	0	0
68	FIB.transitioning.motility_remodelling	6.21	Significant	—	0.00	Relevant	0	0
69	CHOND.pro_inflammatory	6.14	Significant	1.00	0.71	Relevant	181	351
70	MESO.baseline	5.79	Significant	0.52	1.04	Other	0	6
71	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	5.74	Significant	—	1.44	Relevant	0	0
72	FIB.adventitial.complement_angiocrine	5.66	Significant	1.00	0.61	Relevant	153	684
73	ASTRO.A1_reactive	5.61	Significant	1.00	0.65	Other	433	394
74	EC.venous.cardiac_structural	5.61	Significant	0.01	1.53	Other	102	229
75	OLG.myelinating_mature	5.58	Significant	0.13	1.49	Other	363	94
76	OLG.myelinating_stress	5.56	Significant	0.60	1.21	Other	232	62
77	OLG.reactive_repair	5.54	Significant	0.13	1.73	Relevant	385	385
78	EC.liver_sinusoidal.hypoxia_metabolic	5.23	Nominal	1.00	0.00	Other	183	107
79	CHOND.angiogenic	5.19	Nominal	—	0.00	Other	0	0
80	FIB.reticular.immune_interface	5.18	Nominal	—	0.29	Other	1	6
81	OLG.regulatory	5.09	Nominal	1.00	0.53	Other	353	73
82	OLG.regulatory_activated	4.89	Nominal	1.00	0.71	Other	196	614
83	OLG.vesicle_trafficking	4.77	Nominal	0.77	1.05	Other	124	10
84	T.CD8_Tem.signaling_turnover	4.76	Nominal	0.06	1.53	Other	425	683
85	IPSC.stromal_primed	4.75	Nominal	0.04	1.22	Other	0	0
86	T.CD8_Tem.motility_primed	4.64	Nominal	0.07	1.52	Other	269	4
87	CHOND.articular_collagen	4.61	Nominal	1.00	9.46e-03	Other	551	266
88	OLG.stress	4.54	Nominal	1.00	0.26	Other	232	8
89	FIB.adventitial.inflammatory_activated	4.53	Nominal	1.00	0.30	Other	100	473
90	EC.arterial.ion_pump	4.52	Nominal	0.58	1.06	Other	3	2
91	EC.arterial.arteriole_interface	4.47	Nominal	0.58	1.09	Other	31	12
92	EC.lymphatic.baseline	4.39	Nominal	0.76	1.00	Other	38	72
93	NK.adaptive_classII_inhibitory	4.38	Nominal	3.30e-06	2.10	Other	880	154
94	NK.adaptive_biosynthetic_primed	4.34	Nominal	0.06	1.63	Other	244	405
95	EC.lymphatic.tip_migratory	4.30	Nominal	0.85	0.74	Other	23	37
96	EC.arterial.arteriole_gas_exchange	4.22	Nominal	0.10	1.23	Other	238	131
97	FIB.adventitial.adhesion_lipid	4.21	Nominal	1.00	0.49	Other	58	209
98	NK.adaptive_axis_baseline	4.20	Nominal	6.07e-06	1.96	Other	1,008	153
99	T.CD8_Tem.TEMRA	4.09	Nominal	0.25	1.18	Other	920	1,088
100	FIB.reticular.ECM_builder	4.02	Nominal	—	0.37	Other	0	0
101	NK.adaptive_HLAE_tuned	4.00	Nominal	3.30e-06	1.94	Other	1,124	189
102	CHOND.remodeling	3.93	Nominal	—	0.00	Other	5	0
103	EC.arterial.angiogenic_tip	3.86	Nominal	—	0.33	Other	30	37
104	T.CD8_Tem.early_helper_like	3.70	Nominal	0.23	1.25	Other	445	755
105	NK.adaptive_adipose_stress	3.45	Nominal	0.75	1.13	Other	374	39
106	IPSC.axial_identity_primed	3.43	Nominal	0.04	1.17	Other	0	0
107	NK.cytokine_quiescent	3.33	Nominal	0.75	1.13	Other	623	1,062
108	EPI.pancreatic_acinar.stress	3.23	Nominal	2.15e-03	1.77	Other	28	28
109	T.CD8_Tem.stress_adapted	3.21	Nominal	0.99	0.64	Other	607	520
110	EPI.hepatic_ductular_cholangiocyte.stress	3.21	Nominal	—	1.32	Other	0	0
111	EC.arterial.mito_contact	3.14	Nominal	0.58	1.05	Other	14	5
112	EPI.thymic_medullary.hormone_xeno_barrier	3.04	Nominal	—	0.30	Other	0	8
113	EC.lymphatic.activated	3.03	Nominal	0.76	0.97	Other	47	73
114	MESO.secretory_structural	2.96	Nonsignificant	—	0.00	Other	0	0
115	NEU.INH_VIP.canonical_disinhibitory	2.93	Nonsignificant	0.02	1.65	Other	59	38
116	EC.arterial.inflammatory	2.93	Nonsignificant	0.10	1.33	Other	63	50
117	HEP.pericentral_lipoprotein.UPR_redox	2.92	Nonsignificant	—	0.67	Other	0	0
118	EPI.thymic_medullary.canonical_alarmin	2.89	Nonsignificant	0.50	1.33	Other	8	17
119	T.CD8_Tem.baseline	2.79	Nonsignificant	0.99	0.59	Other	458	356
120	ASTRO.stress_acute	2.78	Nonsignificant	1.00	0.23	Other	60	56
121	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	2.67	Nonsignificant	—	1.43	Other	0	0
122	HEP.pericentral_lipoprotein.ApoB_coagulation	2.65	Nonsignificant	—	0.00	Other	0	0
123	NK.cytokine_repair_primed	2.61	Nonsignificant	1.00	0.83	Other	266	11
124	NK.cytokine_vascular_patrolling	2.61	Nonsignificant	1.00	0.89	Other	863	94
125	EPI.pancreatic_islet.alpha	2.57	Nonsignificant	—	0.60	Other	152	330
126	NK.cytokine_axis_baseline	2.56	Nonsignificant	1.00	0.80	Other	1,172	116
127	NEU.INH_VIP.opioid	2.53	Nonsignificant	—	0.83	Other	50	9
128	GRNLSA.p53_damage	2.52	Nonsignificant	—	0.94	Other	13	10
129	FIB.tracheal_subepithelial.baseline	2.52	Nonsignificant	—	0.00	Other	0	0
130	GRNLSA.lipid_hypoxia	2.51	Nonsignificant	0.80	1.06	Other	28	0
131	FIB.neurolectin_mucosa.nerve_interface	2.45	Nonsignificant	—	0.51	Other	4	0
132	EC.venous.activated	2.38	Nonsignificant	9.00e-03	1.39	Other	247	752
133	NEU.INH_VIP.serotonergic	2.37	Nonsignificant	—	0.70	Other	9	2
134	EPI.thymic_medullary.stress_APC	2.25	Nonsignificant	0.80	0.61	Other	2	4
135	NK.cytokine_biosynthetic_primed	2.24	Nonsignificant	1.00	0.52	Other	360	21
136	ASTRO.neuromodulatory	2.18	Nonsignificant	1.00	0.04	Other	34	172
137	HPC.MPP_activated	2.14	Nonsignificant	—	1.31	Other	0	0
138	EC.arterial.homeostatic	2.14	Nonsignificant	1.00	0.74	Other	24	3
139	FIB.neurolectin_mucosa.remodeling_repair	2.06	Nonsignificant	—	0.13	Other	4	2
140	FIB.reticular.stromal_niche	2.05	Nonsignificant	0.85	0.64	Other	0	0
141	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.02	Nonsignificant	—	1.15	Other	0	0
142	NK.adaptive_immature_precursor	2.02	Nonsignificant	1.00	0.35	Other	358	111
143	NK.adaptive_terminal_cytotoxic	2.00	Nonsignificant	1.00	0.49	Other	485	802
144	FIB.perivascular_interface.vasomotor_tone	2.00	Nonsignificant	—	1.21	Other	0	0
145	EPI.pancreatic_acinar.inflammatory_regenerative	1.99	Nonsignificant	0.07	1.61	Other	25	113
146	GRNLSA.stress_metabolic	1.95	Nonsignificant	—	0.38	Other	1	2
147	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.93	Nonsignificant	—	0.97	Other	0	0
148	OPC.proliferative_immune_interact	1.88	Nonsignificant	0.01	1.99	Other	180	373
149	FIB.neurolectin_mucosa.inflammatory	1.87	Nonsignificant	0.88	0.73	Other	52	110
150	SMC.contractile	1.85	Nonsignificant	0.07	1.31	Other	80	588
151	EPI.pancreatic_islet.delta	1.85	Nonsignificant	—	0.67	Other	0	0
152	EC.capillary.inflammatory	1.84	Nonsignificant	0.31	1.24	Other	27	51
153	FIB.hepatic_stellate_cell.contractile	1.76	Nonsignificant	—	1.15	Other	0	0
154	FIB.hepatic_stellate_cell.inflammatory	1.73	Nonsignificant	—	0.32	Other	0	0
155	FIB.neurolectin_mucosa.axon_responsive	1.72	Nonsignificant	0.88	0.43	Other	10	10
156	NEU.INH_VIP.excitatory_coupled	1.71	Nonsignificant	—	0.18	Other	13	0
157	OPC.premyelinating	1.64	Nonsignificant	0.66	1.05	Other	185	12
158	GRNLSA.EMT_insulin_signaling	1.63	Nonsignificant	0.73	1.18	Other	47	84
159	MUSC.activated_migratory	1.62	Nonsignificant	2.07e-03	1.94	Other	6	7
160	NEU.INH_VIP.regulatory_remodeling	1.53	Nonsignificant	—	0.04	Other	6	1
161	EPI.alveolar_type_2.injury_primed	1.53	Nonsignificant	3.44e-05	2.21	Other	434	245
162	GRNLSA.cholesterol_mevalonate	1.50	Nonsignificant	0.98	0.85	Other	9	4
163	FIB.perivascular_interface.lipid_shuttle	1.50	Nonsignificant	—	0.00	Other	51	170
164	FIB.hepatic_stellate_cell.fibrogenic	1.49	Nonsignificant	—	0.00	Other	0	0
165	MAC.kupffer.fibrogenic	1.48	Nonsignificant	—	0.99	Other	0	0
166	SMC.activated	1.45	Nonsignificant	0.07	1.27	Other	2	5
167	T.CD8_transitional.APC_like	1.40	Nonsignificant	0.08	1.20	Other	205	62
168	EC.arterial.metabolic	1.36	Nonsignificant	1.00	0.81	Other	195	159
169	FIB.perivascular_interface.vascular_BM_remodelling	1.34	Nonsignificant	—	0.00	Other	0	0
170	EPI.tracheal_submucosal_gland.acinar_serous	1.34	Nonsignificant	—	0.73	Other	0	0
171	EC.capillary.activated	1.34	Nonsignificant	0.99	1.19	Other	2	5
172	MAC.kupffer.monocyte_like	1.32	Nonsignificant	—	1.03	Other	0	0
173	NK.cytokine_tissue_activation	1.29	Nonsignificant	1.00	0.36	Other	267	450
174	T.CD4_cytotoxic.terminal_effector	1.29	Nonsignificant	0.15	1.33	Other	286	21
175	CM.inflammatory	1.26	Nonsignificant	—	2.83	Other	0	0
176	MAC.resident_cardiac.phagocytic_homeostasis	1.21	Nonsignificant	0.03	1.72	Other	564	1,221
177	EC.venous.remodeling_stalk	1.20	Nonsignificant	1.00	0.93	Other	559	566
178	SCHWN.axon_contact_cardiac	1.18	Nonsignificant	0.19	1.47	Other	18	63
179	FIB.barrier_secretory.remodeling	1.16	Nonsignificant	—	0.64	Other	0	0
180	IPSC.neural_primed	1.14	Nonsignificant	1.00	0.76	Other	0	0
181	MEL.neurotrophic_migratory	1.12	Nonsignificant	—	1.08	Other	0	0
182	FIB.interstitial.immune_interact	1.11	Nonsignificant	0.52	1.16	Other	12	1
183	T.CD8_transitional.effector_primed	1.10	Nonsignificant	0.23	1.13	Other	435	151
184	IPSC.proliferative	1.08	Nonsignificant	1.00	0.78	Other	0	0
185	EPI.thymic_medullary.proliferative_APC	1.08	Nonsignificant	—	0.00	Other	0	0
186	HPC.GMP_granulocytic	1.08	Nonsignificant	—	0.43	Other	3	3
187	NEU.EXC_SYT2.synaptic	1.05	Nonsignificant	—	0.48	Other	0	0
188	OPC.homeostatic	1.05	Nonsignificant	1.00	0.00	Other	394	160
189	EC.capillary.stress	1.05	Nonsignificant	0.99	1.00	Other	44	36
190	FIB.interstitial.mesenchymal_regulator	1.04	Nonsignificant	0.52	1.28	Other	4	4
191	FIB.skin_tenogenic.baseline	1.04	Nonsignificant	—	0.00	Other	0	2
192	SCHWN.translation_boost	1.01	Nonsignificant	—	0.00	Other	8	1
193	THYMO.DN_preTCR	1.00	Nonsignificant	0.01	1.18	Other	41	71
194	MEL.stress_glucocorticoid	0.98	Nonsignificant	0.13	1.70	Other	11	34
195	EPI.alveolar_type_2.stress_response	0.98	Nonsignificant	1.00	0.81	Other	675	1,562
196	FIB.skin_sheath.neuro_vascular_interface	0.96	Nonsignificant	—	0.59	Other	0	0
197	T.CD8_transitional.stress	0.95	Nonsignificant	—	0.44	Other	24	34
198	NEU.INH_VIP.cannabinoid	0.94	Nonsignificant	—	0.00	Other	0	0
199	EC.capillary.baseline	0.93	Nonsignificant	0.99	0.98	Other	246	560
200	FIB.interstitial.stress_secretory	0.93	Nonsignificant	0.52	1.11	Other	92	56
201	NEU.INH_VIP.nuclear_reg	0.92	Nonsignificant	—	0.00	Other	20	4
202	FIB.interstitial.remodeling	0.92	Nonsignificant	0.52	1.12	Other	31	9
203	FIB.skin_sheath.ECM_immune	0.89	Nonsignificant	—	0.00	Other	0	0
204	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.88	Nonsignificant	0.06	1.56	Other	7	16
205	MAC.kupffer.inflammatory	0.88	Nonsignificant	—	0.53	Other	7	4
206	SCHWN.reactive_inflammatory	0.86	Nonsignificant	—	0.00	Other	0	0
207	MG.baseline	0.84	Nonsignificant	0.41	1.45	Other	16	5
208	FIB.interstitial.mesenchymal_APC	0.84	Nonsignificant	0.52	1.05	Other	81	33
209	MAC.resident_cardiac.antigen_presenting	0.84	Nonsignificant	0.99	0.43	Other	52	27
210	MG.phagocytic_APC	0.82	Nonsignificant	0.77	0.72	Other	25	8
211	HPC.MPP_IEG	0.80	Nonsignificant	0.88	1.14	Other	45	46
212	T.CD4_cytotoxic.NK_adapted	0.76	Nonsignificant	0.94	1.04	Other	82	33
213	FIB.skin_papillary.baseline	0.74	Nonsignificant	—	0.00	Other	0	0
214	MG.expanding	0.74	Nonsignificant	0.77	0.73	Other	2	1
215	FIB.barrier_purinergic.stress_GF_binding	0.73	Nonsignificant	—	0.97	Other	0	0
216	GRNLSA.proliferative_migratory	0.73	Nonsignificant	2.74e-04	1.70	Other	248	292
217	MUSC.early_activation	0.72	Nonsignificant	0.93	1.08	Other	4	32
218	EPI.pancreatic_acinar.quiet_dedifferentiation	0.69	Nonsignificant	1.00	0.77	Other	142	171
219	EPI.pancreatic_acinar.baseline	0.68	Nonsignificant	0.99	1.01	Other	274	163
220	EC.arterial.elastic	0.68	Nonsignificant	1.00	0.62	Other	22	45
221	NEU.EXC_NTNG1.synaptic	0.67	Nonsignificant	—	0.67	Other	0	0
222	NEU.INH_VIP.enkephalinergic	0.67	Nonsignificant	—	0.00	Other	0	0
223	FIB.interstitial.lipid_matrix	0.67	Nonsignificant	0.99	0.39	Other	258	191
224	MAC.kupffer.tolerogenic	0.67	Nonsignificant	—	0.36	Other	45	49
225	GRNLSA.secretory_remodeling	0.65	Nonsignificant	0.98	0.54	Other	90	25
226	FIB.lung_alveolar.mito_secretory	0.64	Nonsignificant	—	0.48	Other	0	0
227	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.64	Nonsignificant	—	0.24	Other	5	3
228	EC.venous.quiescent_homeostatic	0.64	Nonsignificant	1.00	0.71	Other	456	360
229	HPC.GMP_inflammatory	0.63	Nonsignificant	0.88	1.04	Other	20	10
230	FIB.skin_sheath.stress_chaperone	0.63	Nonsignificant	—	0.00	Other	0	0
231	EC.venous.baseline	0.61	Nonsignificant	1.00	0.36	Other	346	807
232	EC.capillary.angiocrine	0.60	Nonsignificant	0.99	0.87	Other	250	630
233	T.CD4_cytotoxic.activated	0.60	Nonsignificant	0.94	0.70	Other	3	1
234	EPI.pancreatic_islet.beta	0.60	Nonsignificant	0.98	0.31	Other	42	57
235	EPI.pancreatic_acinar.adhesion_remodeling	0.59	Nonsignificant	1.00	0.58	Other	210	784
236	MEL.secretory_quiescent	0.59	Nonsignificant	0.92	0.89	Other	19	13
237	NK.cytokine_lung_immediate_early	0.59	Nonsignificant	1.00	0.23	Other	424	274
238	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.59	Nonsignificant	—	0.10	Other	0	0
239	PC.IgG_systemic.interacting	0.58	Nonsignificant	0.60	1.26	Other	0	0
240	MEL.mature_oxidative_traffic	0.58	Nonsignificant	0.92	0.49	Other	247	285
241	FIB.suburothelial.homeostasis_matrix	0.57	Nonsignificant	4.92e-03	2.19	Other	258	921
242	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.57	Nonsignificant	—	0.00	Other	6	9
243	MAC.microglia_like.patrolling_adhesive	0.56	Nonsignificant	—	1.01	Other	0	0
244	EC.venous.adipose_lipid	0.55	Nonsignificant	1.00	0.64	Other	254	476
245	MAC.resident_cardiac.inflammatory_reparative	0.54	Nonsignificant	0.99	0.08	Other	31	96
246	FIB.skin_neurosecretory.baseline	0.54	Nonsignificant	—	0.00	Other	0	0
247	EPI.alveolar_type_2.baseline_surfactant	0.53	Nonsignificant	1.00	0.12	Other	64	9
248	PLAT.adhesion	0.52	Nonsignificant	—	0.48	Other	0	0
249	GRNLSA.chemokine_mechanosensory	0.52	Nonsignificant	0.98	0.53	Other	1	0
250	EPI.alveolar_type_1.activated	0.51	Nonsignificant	—	1.64	Other	0	0
251	GRNLSA.angiocrine_mechanosensory	0.51	Nonsignificant	—	0.00	Other	0	0
252	NEU.EXC_IT.adhesion	0.51	Nonsignificant	0.46	1.20	Other	252	108
253	SMC.metabolic	0.51	Nonsignificant	1.00	0.45	Other	14	40
254	FIB.barrier_secretory.homeostasis	0.51	Nonsignificant	—	0.00	Other	0	0
255	EPI.extrahepatic_cholangiocyte.barrier_interface	0.50	Nonsignificant	—	0.00	Other	0	0
256	MUSC.quiescent_reservoir	0.50	Nonsignificant	0.94	0.31	Other	2	8
257	NEU.EXC_NTNG1.nuclear_reg	0.50	Nonsignificant	—	0.00	Other	0	0
258	PC.IgG_systemic.stress	0.50	Nonsignificant	—	0.38	Other	1	5
259	EC.capillary.migratory	0.49	Nonsignificant	0.99	0.78	Other	181	509
260	T.CD4_Tem.cytotoxic_effector	0.49	Nonsignificant	0.02	1.13	Other	225	398
261	FIB.suburothelial.inflammatory_prostanoid	0.49	Nonsignificant	—	0.16	Other	0	0
262	NEU.EXC_IT.neuromodulated	0.49	Nonsignificant	0.46	1.20	Other	176	116
263	FIB.suburothelial.contractile_myofibroblast	0.49	Nonsignificant	—	0.30	Other	9	0
264	ASPC.activated	0.49	Nonsignificant	0.66	1.22	Other	164	162
265	FIB.lung_alveolar.stress_interacting	0.47	Nonsignificant	—	0.00	Other	0	0
266	EPI.cervical_suprabasal.inflammatory_repair	0.47	Nonsignificant	—	0.00	Other	0	0
267	PC.IgG_systemic.metabolic	0.46	Nonsignificant	0.60	0.91	Other	46	63
268	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.44	Nonsignificant	—	0.00	Other	0	0
269	MUSC.baseline	0.44	Nonsignificant	0.94	0.36	Other	0	0
270	IPSC.mesenchymal_primed	0.43	Nonsignificant	1.00	0.50	Other	0	0
271	NEU.EXC_IT.structural	0.43	Nonsignificant	0.46	1.28	Other	171	41
272	NEU.INH_VIP.matrix	0.42	Nonsignificant	—	0.00	Other	24	77
273	HPC.LMPP	0.41	Nonsignificant	0.96	0.91	Other	65	31
274	T.gamma_delta.cytotoxic_effector	0.40	Nonsignificant	0.05	1.17	Other	349	109
275	PERI.inflammatory	0.40	Nonsignificant	3.68e-04	1.78	Other	40	77
276	IPSC.midbrain_primed	0.40	Nonsignificant	1.00	0.52	Other	0	0
277	NEU.INH_LAMP5.rosehip	0.39	Nonsignificant	—	0.53	Other	0	0
278	IPSC.neuroendocrine_primed	0.39	Nonsignificant	—	0.00	Other	0	0
279	NEU.INH_LAMP5.glial_interface	0.39	Nonsignificant	—	0.33	Other	0	0
280	EPI.ectocervical_granular.secretory_apocrine	0.36	Nonsignificant	—	1.15	Other	0	0
281	T.CD8_transitional.Trm_primed	0.36	Nonsignificant	0.94	0.93	Other	108	15
282	T.CD4_Tfh.canonical_GC_helper	0.35	Nonsignificant	0.41	1.17	Other	1	2
283	EC.capillary.postcap_venule	0.35	Nonsignificant	0.99	0.90	Other	355	261
284	EPI.tracheal_submucosal_gland.ductal_luminal	0.35	Nonsignificant	—	0.00	Other	0	0
285	EPI.pancreatic_ductal_bicarbonate.stress	0.34	Nonsignificant	—	1.08	Other	12	33
286	ASPC.stem_like_progenitor	0.34	Nonsignificant	0.66	1.06	Other	300	842
287	NEU.EXC_IT.transitional	0.34	Nonsignificant	0.93	0.93	Other	237	142
288	PERI.baseline	0.33	Nonsignificant	0.27	1.26	Other	39	66
289	NEU.INH_VIP.develop_niche	0.33	Nonsignificant	—	0.00	Other	0	0
290	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.33	Nonsignificant	—	0.00	Other	0	0
291	PC.IgA_muocsal.activated	0.33	Nonsignificant	0.73	0.99	Other	17	8
292	PC.IgA_muocsal.migratory	0.32	Nonsignificant	0.73	1.07	Other	4	1
293	NEU.INH_VIP.LAMP5_hybrid	0.31	Nonsignificant	—	0.00	Other	1	9
294	ASPC.niche_keeping_progenitor	0.31	Nonsignificant	0.66	1.11	Other	52	219
295	NEU.INH_LAMP5.exc_inh_balance	0.31	Nonsignificant	—	0.15	Other	46	2
296	MEL.dedifferentiated_migratory	0.31	Nonsignificant	—	0.00	Other	0	0
297	PC.IgG_systemic.secretory	0.30	Nonsignificant	0.60	0.98	Other	0	0
298	EPI.hepatic_ductular_cholangiocyte.polarity	0.29	Nonsignificant	—	0.00	Other	0	0
299	T.CD4_cytotoxic.baseline	0.28	Nonsignificant	0.94	0.55	Other	0	0
300	PERI.angiocrine	0.28	Nonsignificant	0.87	0.91	Other	93	102
301	EPI.pancreatic_acinar.metabolic_onecarbon	0.26	Nonsignificant	1.00	0.12	Other	287	328
302	EPI.skin_appendage_keratinocyte.transit_amplifying	0.26	Nonsignificant	—	0.28	Other	109	358
303	PC.IgA_muocsal.baseline	0.25	Nonsignificant	0.80	0.84	Other	3	5
304	PC.IgA_muocsal.plasmablast	0.25	Nonsignificant	0.73	0.97	Other	5	4
305	EPI.colonocyte.ionocyte_BEST4	0.24	Nonsignificant	0.80	1.31	Other	103	188
306	MAC.microglia_like.inflammatory_chemokine	0.23	Nonsignificant	—	0.00	Other	20	32
307	FIB.suburothelial.urothelial_interface	0.23	Nonsignificant	1.00	0.00	Other	9	8
308	EC.capillary.angiogenic_tip	0.23	Nonsignificant	0.99	0.50	Other	186	218
309	PERI.cardiac_skeletal	0.23	Nonsignificant	1.00	0.39	Other	313	630
310	ASPC.inflammatory	0.22	Nonsignificant	0.66	1.13	Other	21	61
311	NK.cytokine_tissue_resident	0.21	Nonsignificant	1.00	0.09	Other	74	82
312	MAC.alveolar.biosynthetic_sterol_heme	0.21	Nonsignificant	0.45	1.19	Other	347	40
313	MAC.alveolar.stress_metabolic	0.21	Nonsignificant	0.45	1.15	Other	116	148
314	CM.contractile_oxphos	0.21	Nonsignificant	0.61	1.23	Other	6	19
315	MAC.microglia_like.phagocytic_redox	0.21	Nonsignificant	—	0.00	Other	0	0
316	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.20	Nonsignificant	—	0.00	Other	39	82
317	MAC.MDM.complement_resolving	0.20	Nonsignificant	0.32	1.08	Other	440	860
318	MAC.resident_iron.APC_iron_sensing	0.20	Nonsignificant	0.50	1.06	Other	211	114
319	EPI.colonocyte.distal_absorptive	0.19	Nonsignificant	—	1.59	Other	0	0
320	FIB.barrier_purinergic.lipid_secretory	0.18	Nonsignificant	—	0.00	Other	0	0
321	T.CD4_Th17.migratory	0.18	Nonsignificant	0.51	1.15	Other	13	23
322	THYMO.DP_early_stress	0.17	Nonsignificant	—	1.01	Other	0	0
323	MAC.MDM.inflammatory_phagocytic	0.16	Nonsignificant	0.88	0.99	Other	199	52
324	EPI.renal_intercalated_cell_type_A.PC_transitional	0.16	Nonsignificant	—	0.00	Other	203	407
325	THYMO.SP_CD8_naive_stress	0.15	Nonsignificant	1.00	1.10	Other	1	1
326	THYMO.SP_CD8_transitional	0.15	Nonsignificant	1.00	1.06	Other	32	75
327	NEU.INH_LAMP5.projecting	0.15	Nonsignificant	—	0.00	Other	0	0
328	GRANU.MAST.resting_granule	0.14	Nonsignificant	—	0.73	Other	0	0
329	EPI.skin_interfollicular_spinous.upper_lipid	0.14	Nonsignificant	—	1.52	Other	6	6
330	ASPC.preadipocyte_lipid_primed	0.14	Nonsignificant	1.00	0.69	Other	331	129
331	EPI.thymic_cortical.secretory_remodeling	0.14	Nonsignificant	—	0.69	Other	4	1
332	EPI.tracheal_suprabasal.secretory_immune	0.13	Nonsignificant	—	0.64	Other	0	0
333	MAC.resident_iron.heme_catabolism	0.13	Nonsignificant	0.50	1.12	Other	30	51
334	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.13	Nonsignificant	1.00	0.05	Other	33	34
335	T.CD4_cytotoxic.precursor	0.12	Nonsignificant	0.94	0.70	Other	156	67
336	EC.lymphatic.valve	0.12	Nonsignificant	—	0.00	Other	0	0
337	EPI.renal_thick_ascending_limb.cation_flux	0.12	Nonsignificant	0.49	1.36	Other	57	95
338	MAC.resident_repair.chemokine_angiocrine	0.12	Nonsignificant	0.74	1.04	Other	87	138
339	GRANU.MAST.activated_acute	0.11	Nonsignificant	—	0.34	Other	0	0
340	EPI.skin_keratinocyte_basal.basement_anchoring	0.11	Nonsignificant	—	0.97	Other	0	0
341	T.CD4_Trm.baseline	0.11	Nonsignificant	0.69	1.10	Other	31	21
342	IPSC.stress	0.11	Nonsignificant	1.00	0.34	Other	0	0
343	THYMO.proliferative_S	0.11	Nonsignificant	1.00	0.95	Other	163	418
344	NEU.EXC_CT.remodeling	0.10	Nonsignificant	—	0.55	Other	23	1
345	ASPC.secretory	0.10	Nonsignificant	1.00	0.63	Other	76	5
346	NK.immature_bridge	0.10	Nonsignificant	1.00	2.43e-03	Other	117	122
347	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.10	Nonsignificant	—	0.00	Other	0	0
348	IPSC.endoderm_primed	0.10	Nonsignificant	1.00	0.40	Other	0	0
349	NEU.EXC_CT.projector	0.10	Nonsignificant	0.51	1.02	Other	87	26
350	NEU.EXC_IT.callosal	0.10	Nonsignificant	1.00	0.27	Other	286	119
351	T.CD8_transitional.early	0.10	Nonsignificant	1.00	0.24	Other	327	55
352	T.CD4_Tcm.RNA_control	0.09	Nonsignificant	0.53	1.21	Other	96	4
353	ASPC.baseline	0.09	Nonsignificant	1.00	0.44	Other	363	170
354	MAC.MDM.APC_dendritic	0.08	Nonsignificant	0.88	0.95	Other	48	15
355	EPI.esophageal_basal.activated_progenitor	0.08	Nonsignificant	0.08	1.75	Other	1	0
356	ASPC.proliferative	0.08	Nonsignificant	1.00	0.70	Other	33	85
357	T.CD4_Trm.metal_stress	0.08	Nonsignificant	0.69	1.16	Other	34	58
358	NEU.EXC_IT.guidance	0.07	Nonsignificant	1.00	0.17	Other	274	63
359	B.germinal_center.DZ_M_phase	0.07	Nonsignificant	—	1.47	Other	0	0
360	NEU.EXC_SYT2.nuclear_reg	0.07	Nonsignificant	—	0.00	Other	0	0
361	T.gamma_delta.early_effector	0.06	Nonsignificant	1.00	0.82	Other	89	0
362	MAC.resident_iron.stress_tolerogenic	0.06	Nonsignificant	—	0.60	Other	0	0
363	EPI.colonocyte.goblet_interface	0.06	Nonsignificant	—	0.94	Other	11	21
364	MAC.kupffer.metabolic	0.06	Nonsignificant	—	0.00	Other	25	36
365	MAC.resident_repair.stress_iron	0.06	Nonsignificant	0.74	1.12	Other	48	97
366	B.memory.activated	0.06	Nonsignificant	0.24	1.14	Other	105	29
367	MAC.kupffer.stress	0.06	Nonsignificant	1.00	0.12	Other	9	3
368	T.CD4_transitional.primed_helper_effector	0.05	Nonsignificant	0.66	1.17	Other	19	43
369	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.05	Nonsignificant	—	0.97	Other	0	0
370	EPI.skin_follicular_keratinizing.root_infundibulum	0.05	Nonsignificant	—	0.71	Other	0	0
371	EPI.skin_hair_follicle_companion.activated_migratory	0.05	Nonsignificant	—	0.00	Other	0	0
372	T.CD8_naive.splicing_enriched	0.05	Nonsignificant	0.54	1.09	Other	120	16
373	T.CD8_naive.nfkb_related	0.05	Nonsignificant	0.54	1.24	Other	1	0
374	T.CD4_naive.neddylation_mitoprot	0.05	Nonsignificant	0.45	1.16	Other	93	56
375	T.CD4_Trm.activated	0.05	Nonsignificant	0.82	1.04	Other	32	26
376	T.CD4_Th17.cytotoxic	0.04	Nonsignificant	0.72	1.05	Other	332	123
377	GRANU.MAST.activated_repair	0.04	Nonsignificant	—	0.00	Other	0	1
378	DC.cDC2.antiviral	0.04	Nonsignificant	0.43	1.13	Other	100	37
379	T.CD4_Tcm.stress	0.04	Nonsignificant	0.80	1.18	Other	5	11
380	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.04	Nonsignificant	—	0.00	Other	0	0
381	T.CD4_naive.homeostatic	0.04	Nonsignificant	0.89	1.06	Other	215	108
382	MAC.LAM.inflammatory_APC	0.04	Nonsignificant	0.21	1.04	Other	872	165
383	MAC.resident_repair.antigen_presenting	0.04	Nonsignificant	0.74	1.02	Other	244	113
384	ILC2.quiescent	0.04	Nonsignificant	—	0.00	Other	0	0
385	EPI.colonic_enteroendocrine.Lcell_peptide	0.04	Nonsignificant	—	0.00	Other	0	0
386	T.CD4_naive.survival_mitoprot	0.04	Nonsignificant	0.26	1.30	Other	13	7
387	EPI.gastric_foveolar.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
388	T.CD4_naive.Treg_like	0.04	Nonsignificant	0.14	1.48	Other	121	72
389	EPI.ileal_enterocyte_absorptive.villus_tip	0.03	Nonsignificant	6.98e-06	1.49	Other	4	3
390	T.CD8_naive.cytokine_dampened	0.03	Nonsignificant	0.54	1.07	Other	71	4
391	EPI.renal_intercalated_cell_type_B.baseline	0.03	Nonsignificant	—	0.00	Other	3	1
392	EPI.lung_club_secretory.ciliogenesis_primed	0.03	Nonsignificant	—	1.47	Other	0	0
393	DC.cDC2.proliferative	0.03	Nonsignificant	—	0.43	Other	39	71
394	T.CD4_Th2.precursor	0.03	Nonsignificant	—	0.48	Other	0	0
395	EPI.pancreatic_ductal_progenitor.ADM_like	0.03	Nonsignificant	—	1.65	Other	0	0
396	EPI.skin_follicular_keratinizing.transit_amplifying	0.03	Nonsignificant	—	0.00	Other	21	49
397	MAC.resident_iron.heme_recycling	0.03	Nonsignificant	—	0.00	Other	30	37
398	T.CD4_Tfh.suppression_exhaustion	0.03	Nonsignificant	0.98	0.91	Other	0	2
399	EPI.esophageal_basal.junctional_barrier	0.03	Nonsignificant	—	0.00	Other	0	0
400	T.MAIT.migratory	0.03	Nonsignificant	0.58	1.42	Other	10	1
401	T.CD8_naive.baseline	0.03	Nonsignificant	0.79	1.00	Other	142	2
402	EPI.colonocyte.junction_remodeling	0.03	Nonsignificant	0.99	0.92	Other	218	305
403	EPI.renal_intercalated_cell_type_A.acid_secretion	0.03	Nonsignificant	0.51	1.04	Other	12	6
404	ILC2.migratory	0.03	Nonsignificant	—	0.23	Other	0	0
405	EPI.ileal_enterocyte_crypt.baseline	0.03	Nonsignificant	0.01	1.52	Other	11	6
406	T.CD4_naive.mature	0.03	Nonsignificant	0.99	1.03	Other	211	100
407	HPC.MEP	0.03	Nonsignificant	0.96	0.65	Other	599	1,195
408	T.CD4_naive.activated_stress	0.03	Nonsignificant	0.99	1.03	Other	339	429
409	T.CD4_naive.mature_mitoprot	0.03	Nonsignificant	0.99	0.97	Other	212	476
410	EPI.renal_immature_ureteric_bud.defense_secretory	0.03	Nonsignificant	0.12	1.22	Other	45	76
411	DC.cDC1.cross_presenting	0.02	Nonsignificant	—	1.01	Other	0	0
412	NEU.EXC_CT.Ca2_signaling	0.02	Nonsignificant	—	0.00	Other	68	17
413	T.CD8_naive.vesicle_secretory	0.02	Nonsignificant	0.54	1.10	Other	42	0
414	HPC.CLP_B_primed	0.02	Nonsignificant	—	0.00	Other	0	0
415	MAC.resident_repair.ECM_stromal_crosstalk	0.02	Nonsignificant	0.86	0.96	Other	95	158
416	T.CD4_naive.survival	0.02	Nonsignificant	0.99	0.86	Other	12	17
417	EPI.lung_multiciliated.mature_motile_cilia	0.02	Nonsignificant	—	1.53	Other	0	0
418	MAC.alveolar.inflammatory	0.02	Nonsignificant	0.91	0.96	Other	208	312
419	EPI.ileal_enterocyte_crypt.proliferative_S	0.02	Nonsignificant	0.51	1.00	Other	4	2
420	T.CD4_Tcm.imprinted_splicing	0.02	Nonsignificant	0.80	1.12	Other	6	17
421	T.CD4_Tcm.Th2_like	0.02	Nonsignificant	0.77	1.22	Other	23	55
422	T.CD4_Treg.tissue_effector	0.02	Nonsignificant	0.46	1.13	Other	16	13
423	MONO.CD14.APC_like	0.02	Nonsignificant	0.11	1.07	Other	1,686	2,493
424	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.02	Nonsignificant	—	0.73	Other	0	0
425	ASPC.adipocyte_capillary_interface	0.02	Nonsignificant	1.00	0.11	Other	21	54
426	T.CD4_naive.neddylation	0.02	Nonsignificant	0.99	0.95	Other	104	222
427	EPI.colonic_tuft.activated	0.02	Nonsignificant	—	0.73	Other	0	0
428	EPI.pancreatic_ductal_perivascular.baseline	0.02	Nonsignificant	0.63	0.92	Other	1	5
429	T.CD8_Trm.inflammatory	0.02	Nonsignificant	0.61	1.09	Other	124	176
430	EPI.skin_sweat_duct_keratinocyte.barrier	0.02	Nonsignificant	—	1.13	Other	0	0
431	T.CD4_transitional.tissue_enagement	0.02	Nonsignificant	0.98	1.04	Other	5	11
432	MONO.CD16.patrolling	0.02	Nonsignificant	1.92e-09	1.34	Other	797	216
433	EPI.ileal_enterocyte_crypt.bile_transport	0.02	Nonsignificant	0.28	1.26	Other	2	0
434	EPI.skin_follicular_keratinizing.upper_infundibulum	0.01	Nonsignificant	—	0.00	Other	8	2
435	T.CD8_Trm.dendritic_recruiter	0.01	Nonsignificant	0.79	0.97	Other	47	85
436	MAC.alveolar.lipid_autophagy	0.01	Nonsignificant	—	0.28	Other	35	44
437	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.01	Nonsignificant	—	0.96	Other	0	0
438	MAC.resident_iron.redox_metabolic	0.01	Nonsignificant	0.50	1.03	Other	4	4
439	EPI.ileal_goblet.immature	0.01	Nonsignificant	—	0.46	Other	0	0
440	EPI.ileal_enterocyte_crypt.villus_transition	0.01	Nonsignificant	—	0.19	Other	7	10
441	T.CD4_Trm.stress_adaptive	0.01	Nonsignificant	0.82	1.05	Other	8	22
442	B.germinal_center.DZ_S_phase	0.01	Nonsignificant	—	0.58	Other	0	0
443	T.CD4_Trm.central_like	0.01	Nonsignificant	0.83	0.98	Other	38	31
444	T.CD8_naive.lipid_synthesis	0.01	Nonsignificant	0.54	1.14	Other	6	4
445	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.01	Nonsignificant	0.97	1.25	Other	14	32
446	EPI.ectocervical_granular.inflammatory	0.01	Nonsignificant	—	0.32	Other	0	0
447	EPI.ileal_goblet.baseline	0.01	Nonsignificant	0.36	1.45	Other	16	2
448	T.CD4_naive.resist_bystander	0.01	Nonsignificant	0.99	0.94	Other	40	25
449	EPI.skin_keratinocyte_progenitor.activated_stress	0.01	Nonsignificant	—	0.38	Other	0	0
450	B.naive.purinergic	0.01	Nonsignificant	0.01	1.15	Other	384	820
451	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.01	Nonsignificant	—	0.00	Other	11	69
452	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.01	Nonsignificant	0.02	1.49	Other	2	9
453	EPI.alveolar_type_1.baseline	0.01	Nonsignificant	1.00	0.00	Other	8	0
454	T.CD4_naive.survival_neddylation	0.01	Nonsignificant	0.99	0.98	Other	26	38
455	EPI.lung_club_secretory.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
456	T.CD4_Tfh.effector_migratory	0.01	Nonsignificant	0.98	0.96	Other	122	57
457	T.CD8_naive.effector_transition	0.01	Nonsignificant	1.00	0.82	Other	35	62
458	ILC2.activated	0.01	Nonsignificant	—	0.00	Other	0	0
459	EPI.colonocyte.crypt_progenitor	0.01	Nonsignificant	0.99	0.84	Other	115	265
460	T.CD4_Th17.baseline	0.01	Nonsignificant	0.94	0.81	Other	51	5
461	ASPC.remodeling	0.01	Nonsignificant	1.00	0.16	Other	106	354
462	EPI.renal_principal_cell.canonical_vasopressin	0.01	Nonsignificant	0.80	1.19	Other	2	0
463	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	1.00	0.90	Other	314	587
464	T.MAIT.early_activation	0.01	Nonsignificant	0.97	1.09	Other	57	4
465	EPI.lung_club_secretory.ciliogenesis_axoneme	0.01	Nonsignificant	—	0.00	Other	0	0
466	EPI.tracheal_basal.activated_stress	0.01	Nonsignificant	0.49	1.24	Other	32	0
467	EPI.ileal_bile_transport.detox_transcytosis	9.85e-03	Nonsignificant	—	0.56	Other	0	1
468	DC.cDC1.proliferative	9.65e-03	Nonsignificant	—	0.16	Other	0	0
469	T.CD4_Tcm.effector_like	9.55e-03	Nonsignificant	0.80	1.08	Other	293	533
470	IPSC.canonical_pluripotent	9.50e-03	Nonsignificant	1.00	0.07	Other	0	0
471	T.CD8_Trm.muscosal_Tc17	9.44e-03	Nonsignificant	0.61	1.11	Other	19	38
472	THYMO.DP_early	9.44e-03	Nonsignificant	1.00	0.81	Other	326	313
473	T.CD8_Trm.cytotoxic	9.42e-03	Nonsignificant	0.79	0.97	Other	165	85
474	CM.translation_boost_RPL	9.13e-03	Nonsignificant	0.97	1.02	Other	129	1
475	T.MAIT.stress	8.88e-03	Nonsignificant	—	0.18	Other	0	0
476	EPI.renal_principal_cell.intercalated_like	8.77e-03	Nonsignificant	0.80	1.21	Other	63	66
477	T.CD4_Tcm.baseline	8.70e-03	Nonsignificant	0.80	1.11	Other	61	31
478	B.naive.metabolic	8.68e-03	Nonsignificant	0.87	1.06	Other	50	79
479	T.CD4_Tcm.Tfh_like	8.53e-03	Nonsignificant	0.87	1.01	Other	102	214
480	DC.cDC1.baseline	8.28e-03	Nonsignificant	—	0.00	Other	0	0
481	EPI.hepatic_ductular_cholangiocyte.ion_transport	8.14e-03	Nonsignificant	—	0.00	Other	0	0
482	CM.baseline	7.86e-03	Nonsignificant	0.97	0.97	Other	393	0
483	EPI.ileal_goblet.inflammatory_mucin	7.73e-03	Nonsignificant	0.66	0.83	Other	6	9
484	B.memory.preactivated	7.67e-03	Nonsignificant	0.81	1.03	Other	173	174
485	DC.cDC2.tolerogenic_regulatory	7.56e-03	Nonsignificant	1.00	0.94	Other	44	4
486	EPI.lung_club_secretory.canonical_surfactant	7.55e-03	Nonsignificant	—	0.00	Other	74	104
487	EPI.salivary_duct_excretory.stress	7.34e-03	Nonsignificant	0.67	0.93	Other	33	68
488	EPI.skin_hair_follicle_bulge.quiescent	7.26e-03	Nonsignificant	0.16	1.35	Other	56	69
489	DC.cDC1.homeostatic_inhibitory	7.25e-03	Nonsignificant	—	0.00	Other	0	0
490	EPI.renal_proximal_tubule.onecarbon_peroxisome	7.19e-03	Nonsignificant	6.55e-03	1.89	Other	58	89
491	B.naive.activated	7.15e-03	Nonsignificant	0.87	1.02	Other	77	127
492	B.age_associated.activated	7.12e-03	Nonsignificant	—	0.23	Other	18	22
493	EPI.ileal_goblet.stress_metallothionein	7.01e-03	Nonsignificant	—	0.00	Other	4	11
494	EPI.skin_interfollicular_spinous.stress_oxidative	6.75e-03	Nonsignificant	—	0.71	Other	0	0
495	EPI.salivary_intercalated_defense.canonical_antimicrobial	6.67e-03	Nonsignificant	2.52e-04	1.20	Other	11	22
496	NEU.INH_PVALB.chandelier	6.57e-03	Nonsignificant	0.12	1.26	Other	19	16
497	T.MAIT.MAPK_brake	6.45e-03	Nonsignificant	0.97	0.98	Other	44	66
498	T.CD4_Tcm.migratory_cilium	6.44e-03	Nonsignificant	0.87	1.03	Other	5	10
499	T.CD4_naive.purinergic	6.40e-03	Nonsignificant	0.99	0.85	Other	49	1
500	EPI.salivary_duct_excretory.baseline	6.34e-03	Nonsignificant	0.67	0.88	Other	23	57
501	T.CD8_naive.innate_like	6.08e-03	Nonsignificant	1.00	0.56	Other	10	1
502	T.CD4_naive.proteostasis	6.02e-03	Nonsignificant	0.99	0.64	Other	14	9
503	T.MAIT.vesicle	5.98e-03	Nonsignificant	0.97	0.86	Other	37	65
504	T.CD4_transitional.APC_interacting	5.91e-03	Nonsignificant	0.98	0.99	Other	10	14
505	T.CD8_Tcm.effector_bias	5.87e-03	Nonsignificant	0.52	1.15	Other	199	329
506	T.CD4_Tfh.precursor_migratory	5.87e-03	Nonsignificant	0.98	0.70	Other	72	27
507	EPI.skin_sweat_duct_keratinocyte.repair	5.82e-03	Nonsignificant	—	0.51	Other	0	0
508	T.CD4_Tem.inflammatory	5.76e-03	Nonsignificant	1.00	0.76	Other	28	6
509	T.CD4_Tcm.synapse_dynamics	5.58e-03	Nonsignificant	0.87	0.96	Other	15	10
510	EPI.lung_multiciliated.baseline	5.52e-03	Nonsignificant	—	0.51	Other	0	7
511	DC.cDC1.activated	5.34e-03	Nonsignificant	—	0.00	Other	0	0
512	NEU.EXC_CT.Ca2_sensor	5.32e-03	Nonsignificant	—	0.00	Other	0	0
513	EPI.pancreatic_ductal_progenitor.baseline	5.22e-03	Nonsignificant	0.71	0.87	Other	179	702
514	EPI.skin_keratinocyte_basal.transit_amplifying	5.17e-03	Nonsignificant	—	0.00	Other	0	0
515	EPI.tracheal_basal.homeostatic_progenitor	5.12e-03	Nonsignificant	0.85	0.71	Other	285	74
516	T.CD4_Tcm.DC_interact	5.10e-03	Nonsignificant	0.89	0.91	Other	72	32
517	T.CD4_Tcm.tissue_homing	5.02e-03	Nonsignificant	0.89	0.90	Other	78	46
518	T.CD4_Tcm.regulatory_poised	5.02e-03	Nonsignificant	0.87	0.94	Other	2	3
519	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	4.90e-03	Nonsignificant	—	0.37	Other	0	0
520	B.memory.baseline	4.78e-03	Nonsignificant	0.95	0.89	Other	472	99
521	T.CD4_Trm.cytotoxic_effector	4.78e-03	Nonsignificant	0.96	0.84	Other	118	77
522	EPI.skin_hair_follicle_bulge.anagen_growth	4.75e-03	Nonsignificant	—	0.27	Other	0	0
523	EPI.colonic_tuft.homeostatic	4.66e-03	Nonsignificant	—	0.00	Other	0	0
524	T.CD4_transitional.baseline	4.46e-03	Nonsignificant	0.99	0.72	Other	59	97
525	EPI.colonocyte.proximal_transport	4.41e-03	Nonsignificant	0.99	0.56	Other	24	12
526	EPI.pancreatic_ductal_bicarbonate.baseline	4.28e-03	Nonsignificant	0.97	0.94	Other	11	42
527	T.CD4_naive.proteostasis_mitoprot	4.24e-03	Nonsignificant	0.99	0.65	Other	15	37
528	B.age_associated.migratory	4.23e-03	Nonsignificant	0.43	1.07	Other	2	2
529	B.naive.restrained	4.16e-03	Nonsignificant	0.87	0.94	Other	183	353
530	T.CD4_Trm.helper_like	4.05e-03	Nonsignificant	0.96	0.76	Other	84	147
531	EPI.ileal_enterocyte_crypt.proliferative_G2M	3.92e-03	Nonsignificant	—	0.00	Other	19	54
532	EPI.pancreatic_ductal_progenitor.ciliated_transport	3.84e-03	Nonsignificant	—	0.00	Other	105	368
533	T.CD8_Trm.homeostatic	3.63e-03	Nonsignificant	0.98	0.77	Other	42	5
534	MONO.CD16.platelet_bound	3.56e-03	Nonsignificant	1.00	0.95	Other	372	508
535	EPI.ileal_bile_transport.absorptive_xenobiotic	3.49e-03	Nonsignificant	0.89	0.55	Other	11	12
536	T.CD4_Tcm.retro_ZNF117	3.42e-03	Nonsignificant	0.87	0.96	Other	5	9
537	EPI.salivary_myoepithelial.contractile_repair	3.36e-03	Nonsignificant	—	0.76	Other	3	9
538	T.MAIT.quiescent	3.33e-03	Nonsignificant	0.97	0.52	Other	100	5
539	EPI.renal_thick_ascending_limb.barrier_repair	3.16e-03	Nonsignificant	0.73	1.00	Other	141	284
540	T.MAIT.cytotoxic	3.15e-03	Nonsignificant	0.97	0.58	Other	52	15
541	EPI.skin_keratinocyte_basal.spinous_transition	3.04e-03	Nonsignificant	—	0.00	Other	0	0
542	EPI.cervical_suprabasal.secretory_vesicle	3.04e-03	Nonsignificant	—	0.00	Other	0	0
543	EPI.salivary_serous_acinar.quiescent	2.99e-03	Nonsignificant	0.57	1.10	Other	178	493
544	EPI.endocervical_secretory.squamous_barrier	2.92e-03	Nonsignificant	—	0.67	Other	0	0
545	T.CD4_transitional.primed_cytotoxic	2.88e-03	Nonsignificant	0.99	0.83	Other	28	30
546	CM.osmoprotection	2.85e-03	Nonsignificant	0.97	0.92	Other	34	57
547	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.85e-03	Nonsignificant	—	1.27	Other	0	0
548	EPI.skin_hair_follicle_bulge.niche_crosstalk	2.79e-03	Nonsignificant	—	0.00	Other	29	88
549	EPI.renal_proximal_tubule.detox_antioxidant	2.69e-03	Nonsignificant	1.00	0.00	Other	394	77
550	EPI.renal_thick_ascending_limb.remodeling	2.67e-03	Nonsignificant	0.73	1.01	Other	152	92
551	EPI.renal_thick_ascending_limb.canonical_salt_transporter	2.67e-03	Nonsignificant	0.79	0.87	Other	322	317
552	EPI.skin_sebaceous_duct_luminal.immune_interface	2.46e-03	Nonsignificant	—	0.09	Other	0	0
553	EPI.esophageal_suprabasal.differentiating_keratin	2.42e-03	Nonsignificant	0.53	0.99	Other	131	61
554	EPI.esophageal_suprabasal.basal_transitional	2.41e-03	Nonsignificant	0.53	1.20	Other	44	67
555	EPI.renal_distal_tubule.ciliated_remodelling	2.38e-03	Nonsignificant	—	1.64	Other	0	0
556	B.naive.proteostasis	2.38e-03	Nonsignificant	0.87	0.92	Other	49	69
557	EPI.ectocervical_granular.immune_interact	2.31e-03	Nonsignificant	—	0.00	Other	0	0
558	MONO.CD14.platelet_bound	2.25e-03	Nonsignificant	0.37	1.08	Other	964	176
559	T.CD4_Tcm.crosstalk_myeloid	2.24e-03	Nonsignificant	0.87	0.93	Other	5	4
560	B.memory.migratory	2.18e-03	Nonsignificant	0.95	0.78	Other	123	208
561	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	2.16e-03	Nonsignificant	—	0.00	Other	0	0
562	EPI.salivary_duct_ion_transport.baseline	2.09e-03	Nonsignificant	—	—	Other	0	0
563	EPI.renal_principal_cell.injury_repair	2.02e-03	Nonsignificant	0.87	0.68	Other	26	9
564	B.naive.antigen_presenting_ready	1.92e-03	Nonsignificant	0.87	0.90	Other	48	73
565	B.naive.remodeling	1.86e-03	Nonsignificant	0.87	0.95	Other	135	230
566	EPI.salivary_serous_acinar.secretory_active	1.85e-03	Nonsignificant	0.76	0.96	Other	242	69
567	EPI.renal_principal_cell.activated_acute	1.85e-03	Nonsignificant	0.87	0.88	Other	29	59
568	T.CD8_Tcm.NK_like	1.85e-03	Nonsignificant	0.78	1.01	Other	334	581
569	T.CD8_naive.mito_proteostasis	1.82e-03	Nonsignificant	1.00	0.31	Other	428	100
570	B.naive.baseline	1.71e-03	Nonsignificant	0.87	0.89	Other	10	13
571	EPI.skin_interfollicular_spinous.inflammatory	1.68e-03	Nonsignificant	—	0.00	Other	0	0
572	CM.anti_inflammatory	1.67e-03	Nonsignificant	0.97	0.80	Other	424	1,503
573	EPI.renal_thick_ascending_limb.salt_sensing	1.66e-03	Nonsignificant	0.79	0.84	Other	73	103
574	DC.cDC2.pro_inflammatory	1.64e-03	Nonsignificant	1.00	0.96	Other	3	5
575	EPI.skin_interfollicular_spinous.stress_UPR	1.58e-03	Nonsignificant	—	0.32	Other	0	0
576	B.memory.pDC_imprint	1.54e-03	Nonsignificant	0.81	1.10	Other	157	103
577	EPI.bile_duct_cholangiocyte.secretory_mucin	1.54e-03	Nonsignificant	—	0.76	Other	7	12
578	T.CD8_Tcm.helper_like	1.53e-03	Nonsignificant	0.78	0.97	Other	81	159
579	EPI.colonocyte.secretory_boost	1.48e-03	Nonsignificant	0.99	0.27	Other	98	91
580	T.CD4_naive.gut_prone	1.48e-03	Nonsignificant	0.99	0.28	Other	35	70
581	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.46e-03	Nonsignificant	—	0.00	Other	0	0
582	EPI.salivary_myoepithelial.baseline	1.39e-03	Nonsignificant	0.84	1.17	Other	42	141
583	T.CD4_Treg.central_naive_like	1.37e-03	Nonsignificant	0.46	1.06	Other	333	45
584	EPI.ileal_enterocyte_absorptive.brush_border	1.37e-03	Nonsignificant	1.00	0.00	Other	580	1,717
585	CM.sarcomere_actin_interface	1.37e-03	Nonsignificant	0.97	0.84	Other	450	78
586	T.CD8_Tcm.baseline	1.36e-03	Nonsignificant	0.78	0.96	Other	90	89
587	EPI.renal_immature_ureteric_bud.osmoprotective	1.32e-03	Nonsignificant	1.00	0.38	Other	126	44
588	EPI.ileal_enterocyte_crypt.secretory_precursor	1.26e-03	Nonsignificant	—	0.00	Other	0	0
589	B.germinal_center.LZ_memory_precursor	1.24e-03	Nonsignificant	—	0.00	Other	0	0
590	EPI.salivary_myoepithelial.activated	1.23e-03	Nonsignificant	0.85	0.97	Other	85	281
591	CM.oxidative_phospho	1.19e-03	Nonsignificant	0.97	0.79	Other	266	792
592	MAC.LAM.anti_inflammatory	1.17e-03	Nonsignificant	0.86	1.01	Other	86	132
593	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.15e-03	Nonsignificant	—	0.00	Other	0	0
594	THYMO.CD8aa_IELp	1.11e-03	Nonsignificant	—	0.19	Other	1	7
595	DC.mig.baseline	1.10e-03	Nonsignificant	—	0.00	Other	1	0
596	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.09e-03	Nonsignificant	—	0.00	Other	0	0
597	EPI.renal_principal_cell.inflammatory	1.08e-03	Nonsignificant	0.87	0.69	Other	74	157
598	GRANU.neutrophil.primed_degranulation	1.05e-03	Nonsignificant	—	0.38	Other	0	0
599	CM.translation_boost_RPS	1.04e-03	Nonsignificant	0.97	0.83	Other	69	16
600	T.CD4_Th2.tissue_adapted	9.44e-04	Nonsignificant	—	0.00	Other	0	0
601	CM.mito_proteostasis	9.42e-04	Nonsignificant	0.97	0.78	Other	329	29
602	EPI.skin_sebaceous_duct_luminal.detox_repair	9.40e-04	Nonsignificant	0.91	0.58	Other	137	94
603	T.CD4_Tcm.APC_mimicry	8.64e-04	Nonsignificant	0.95	0.70	Other	54	43
604	GRANU.neutrophil.antiviral_endotoxin	8.59e-04	Nonsignificant	—	0.26	Other	0	0
605	EPI.skin_keratinocyte_proliferating.anchor_remodel	8.34e-04	Nonsignificant	—	0.92	Other	0	0
606	B.germinal_center.LZ_selection	7.87e-04	Nonsignificant	—	0.00	Other	0	0
607	EPI.skin_interfollicular_spinous.baseline	7.59e-04	Nonsignificant	0.98	0.79	Other	35	3
608	EPI.skin_sweat_duct_keratinocyte.signal_gate	7.56e-04	Nonsignificant	—	0.00	Other	43	26
609	MONO.CD14.inflammatory	7.54e-04	Nonsignificant	0.36	1.22	Other	92	134
610	EPI.skin_interfollicular_spinous.early_differentiation	7.52e-04	Nonsignificant	0.98	0.75	Other	89	19
611	T.CD4_Tcm.secretory	7.49e-04	Nonsignificant	0.95	0.74	Other	20	11
612	T.gamma_delta.central_memory	7.31e-04	Nonsignificant	1.00	0.32	Other	460	919
613	DC.cDC2.adhesion_signaling	7.29e-04	Nonsignificant	1.00	0.71	Other	35	9
614	THYMO.proliferative_G2M	7.12e-04	Nonsignificant	—	0.00	Other	164	413
615	MAC.proliferating.DNA_replication	6.03e-04	Nonsignificant	0.20	1.13	Other	3	6
616	B.naive.receptor_recycle	5.83e-04	Nonsignificant	0.97	0.70	Other	51	0
617	EPI.salivary_myoepithelial.junctional_transport	5.62e-04	Nonsignificant	0.90	0.60	Other	66	121
618	EPI.salivary_serous_acinar.seromucous_like	5.57e-04	Nonsignificant	—	0.93	Other	0	0
619	T.CD4_Treg.APC_interactive	5.14e-04	Nonsignificant	0.97	0.85	Other	118	28
620	MAC.MDM.LAM_like	5.01e-04	Nonsignificant	0.88	0.81	Other	12	14
621	NEU.INH_PVALB.metabotropic	5.00e-04	Nonsignificant	—	0.41	Other	0	0
622	DC.cDC2.lipid_metabolic	4.79e-04	Nonsignificant	—	0.12	Other	0	0
623	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	4.70e-04	Nonsignificant	—	0.00	Other	0	0
624	MONO.CD16.hepatic_mac_like	4.60e-04	Nonsignificant	1.00	0.80	Other	803	117
625	CM.mechano_activated	4.56e-04	Nonsignificant	0.97	0.65	Other	205	134
626	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	4.24e-04	Nonsignificant	0.97	0.90	Other	219	533
627	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	4.07e-04	Nonsignificant	—	0.00	Other	0	0
628	EPI.colonic_enteroendocrine.progenitor	4.00e-04	Nonsignificant	—	0.00	Other	0	0
629	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	3.89e-04	Nonsignificant	—	0.00	Other	0	0
630	THYMO.SP_CD8_naive	3.79e-04	Nonsignificant	1.00	0.50	Other	297	177
631	EPI.bile_duct_cholangiocyte.inflammatory_APC	3.77e-04	Nonsignificant	—	0.00	Other	2	0
632	MAC.alveolar.capillary_interacting	3.54e-04	Nonsignificant	0.98	0.44	Other	113	181
633	MONO.CD14.cord_tolerance	3.47e-04	Nonsignificant	0.36	1.09	Other	864	753
634	EPI.lung_multiciliated.stress	3.07e-04	Nonsignificant	—	0.00	Other	67	165
635	MONO.CD16.baseline	3.02e-04	Nonsignificant	1.00	0.58	Other	50	1
636	T.CD8_Tcm.gut_homing	2.91e-04	Nonsignificant	0.78	0.90	Other	380	112
637	EPI.endocervical_secretory.secretory_translocon	2.82e-04	Nonsignificant	—	0.00	Other	0	0
638	EPI.esophageal_suprabasal.proliferative_S	2.78e-04	Nonsignificant	—	0.00	Other	26	41
639	T.CD4_Tem.transitional_CM	2.68e-04	Nonsignificant	1.00	0.62	Other	31	20
640	THYMO.SP_CD4_naive	2.47e-04	Nonsignificant	1.00	0.60	Other	65	75
641	B.age_associated.naive_transitional	2.31e-04	Nonsignificant	—	0.00	Other	0	0
642	MAC.LAM.lipid_opsonization	2.25e-04	Nonsignificant	0.86	1.03	Other	45	14
643	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.24e-04	Nonsignificant	0.97	0.95	Other	40	191
644	EPI.skin_interfollicular_spinous.transition_basal	2.21e-04	Nonsignificant	0.98	0.25	Other	100	127
645	NEU.INH_PVALB.nuclear_reg	1.96e-04	Nonsignificant	0.81	0.80	Other	25	12
646	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.67e-04	Nonsignificant	—	0.00	Other	0	0
647	EPI.skin_interfollicular_spinous.proliferative	1.58e-04	Nonsignificant	—	0.00	Other	0	0
648	MONO.CD14.remodeling	1.53e-04	Nonsignificant	0.93	0.99	Other	2,373	295
649	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.46e-04	Nonsignificant	—	0.44	Other	49	237
650	EPI.ectocervical_granular.proliferative_basal	1.45e-04	Nonsignificant	—	0.00	Other	0	0
651	EPI.salivary_mucous_acinar.baseline	1.38e-04	Nonsignificant	—	—	Other	394	683
652	DC.cDC2.migratory	1.34e-04	Nonsignificant	1.00	0.59	Other	185	39
653	EPI.salivary_intercalated_defense.inflammatory	1.33e-04	Nonsignificant	0.97	0.50	Other	152	360
654	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.22e-04	Nonsignificant	—	0.00	Other	135	290
655	DC.cDC2.monocyte_like	1.09e-04	Nonsignificant	1.00	0.70	Other	1,285	791
656	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	1.07e-04	Nonsignificant	—	0.55	Other	0	0
657	MONO.CD14.baseline	8.96e-05	Nonsignificant	1.00	0.95	Other	2,268	76
658	MONO.CD16.inflammatory	8.84e-05	Nonsignificant	1.00	0.43	Other	1,640	168
659	PLAT.megakaryocytic	8.18e-05	Nonsignificant	—	0.00	Other	0	0
660	MAC.alveolar.scavenging_endocytic	7.35e-05	Nonsignificant	—	0.00	Other	140	283
661	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	5.20e-05	Nonsignificant	0.97	0.27	Other	449	1,034
662	MAC.LAM.antimicrobial	4.87e-05	Nonsignificant	0.86	0.98	Other	389	93
663	EPI.esophageal_suprabasal.proliferative_G2M	3.81e-05	Nonsignificant	—	0.00	Other	0	0
664	EPI.skin_keratinocyte_proliferating.detox_repair	3.14e-05	Nonsignificant	—	0.00	Other	0	0
665	EPI.renal_distal_tubule.ion_transport	2.68e-05	Nonsignificant	—	0.86	Other	0	0
666	B.germinal_center.LZ_survival	2.54e-05	Nonsignificant	—	0.00	Other	0	0
667	MAC.resident_repair.lipid_phagocytic	1.91e-05	Nonsignificant	0.86	0.71	Other	228	604
668	MAC.LAM.perivascular_angiocrine	1.32e-05	Nonsignificant	—	0.03	Other	53	138
669	GRANU.neutrophil.tissue_patrolling	1.05e-05	Nonsignificant	—	0.00	Other	0	0
670	EPI.tracheal_suprabasal.transitional_wound	7.20e-06	Nonsignificant	—	0.00	Other	16	1
671	T.CD4_Treg.Tr1_like	6.78e-06	Nonsignificant	—	0.00	Other	8	8
672	EPI.esophageal_suprabasal.proliferative_exit	5.49e-06	Nonsignificant	—	0.00	Other	0	0
673	EPI.renal_distal_tubule.stress	5.46e-06	Nonsignificant	—	0.00	Other	0	0
674	EPI.renal_distal_tubule.repair	4.95e-06	Nonsignificant	—	0.00	Other	34	102
675	MAC.LAM.lipid_phagocytosis	3.80e-06	Nonsignificant	0.99	0.60	Other	369	328
676	NEU.INH_PVALB.fastspike	3.78e-06	Nonsignificant	—	0.00	Other	24	22
677	EPI.pancreatic_ductal_bicarbonate.activated	3.70e-06	Nonsignificant	1.00	0.16	Other	10	7
678	NEU.INH_PVALB.serotonergic	3.40e-06	Nonsignificant	—	0.00	Other	0	0
679	MONO.CD14.repair_M2_like	2.79e-06	Nonsignificant	0.97	0.92	Other	550	1,495
680	EPI.salivary_intercalated_defense.basal_EMT	2.31e-06	Nonsignificant	—	0.00	Other	0	0
681	EPI.renal_distal_tubule.immune_modulatory	2.18e-06	Nonsignificant	—	0.00	Other	0	0
682	DC.pDC.poised_migratory	4.31e-07	Nonsignificant	0.60	1.20	Other	54	95
683	NEU.INH_PVALB.neuromodulatory	1.20e-07	Nonsignificant	—	0.00	Other	0	0
684	DC.pDC.baseline	9.12e-08	Nonsignificant	0.89	0.76	Other	88	123
685	MAC.proliferating.stress	3.79e-08	Nonsignificant	—	0.00	Other	87	136
686	DC.pDC.immature_metabolic	3.28e-08	Nonsignificant	0.89	0.69	Other	78	124
687	EPI.thymic_cortical.baseline	2.22e-09	Nonsignificant	0.86	0.61	Other	185	386
688	EPI.thymic_cortical.Notch_interface	8.32e-10	Nonsignificant	—	0.00	Other	82	137

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

27 unique genes. Showing 1–27. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
SYNE1	02-Medium	0.62	24.86	G1	C2	ASTRO.synaptic_interaction (L2), EC.venous.cardiac_structural (L2), EPI.lung_multiciliated.mature_motile_cilia (L2), EPI.pancreatic_ductal_bicarbonate.repair_actin_junction (L2)	HEP.periportal_metabolic (Tier: specific) ASPC.signal_integrator (Tier: relevant) ASTRO.synaptic_interaction (Tier: relevant)	35 cells — complete matches	5	16
ENSG00000302379	02-Medium	0.47	21.42	G2	C1	—	—	—	13	36
ENSG00000302357	02-Medium	0.46	20.27	G2	C1	—	—	—	5	18
ESR1	02-Medium	0.43	17.46	G2	C1	—	FIB.adventitial (Tier: specific) ASPC.mesothelial_like (Tier: specific) FIB.adventitial.baseline (Tier: relevant) FIB.adventitial.complement_angiocrine (Tier: relevant) FIB.adventitial.mechano_chemo_sensing (Tier: relevant)	40 cells — complete matches	10	19
RSPO3	02-Medium	0.42	5.04	G1	C2	FIB.barrier_secretory (L1S), FIB.tracheal_subepithelial (L1S), ADIPO.thermogenic (L2), IPSC.mesodermal_primed (L2), NEU.EXC_CT.projector (L2)	FIB.transitioning (Tier: specific) SKM.type_1_slow (Tier: specific) ASPC.mesothelial_like (Tier: specific) FIB.adventitial.activated_remodelling (Tier: specific) CHOND.pro_inflammatory (Tier: relevant) EC.heart_remodeling.activated_acute (Tier: relevant) EC.heart_remodeling.angiocrine (Tier: relevant) EC.heart_remodeling.perivascular (Tier: relevant) FIB.adventitial.complement_angiocrine (Tier: relevant) FIB.reticular.stress_metallothionein (Tier: relevant) FIB.transitioning.matrix_stress (Tier: relevant) IPSC.mesodermal_primed (Tier: relevant)	80 cells — complete matches	29	81
ENSG00000226193	02-Medium	0.41	14.97	G2	C2	—	—	—	0	0
ARL14EP-DT	02-Medium	0.40	6.98	G2	C2	—	—	—	1	2
ARL14EP	02-Medium	0.39	6.17	G2	C2	—	—	B.memory.migratory (L2), GRANU.MAST.activated_repair (L2)	0	1
ENSG00000293110	02-Medium	0.37	6.42	G1	C2	—	—	—	10	23
SYNE1-AS1	02-Medium	0.37	13.08	G2	C2	—	FIB.reticular.stress_metallothionein (Tier: relevant)	5 cells — complete matches	0	0
ENSG00000278095	02-Medium	0.36	8.71	G2	C2	—	—	—	4	4
ITPR2-AS1	02-Medium	0.31	6.94	G2	C2	—	—	—	6	7
CDC42	02-Medium	0.30	3.54	G2	C2	—	—	—	9	24
MPPED2	02-Medium	0.28	4.25	G2	C2	—	SKM.type_1_slow (Tier: specific) adipocyte (Tier: relevant) ADIPO.adipocyte (Tier: relevant)	69 cells — complete matches	1	1
ENSG00000287373	02-Medium	0.28	4.69	G2	C2	—	—	—	0	1
MPPED2-AS1	02-Medium	0.27	4.15	G2	C2	—	—	—	0	1
ENSG00000309240	02-Medium	0.26	4.92	G2	C2	—	—	—	0	1
ENSG00000309197	02-Medium	0.25	3.30	G2	C2	—	—	—	2	2
ENSG00000255480	02-Medium	0.24	2.83	G2	C2	—	—	—	0	1
ENSG00000254526	02-Medium	0.22	2.18	G2	C2	—	—	—	0	0
ENSG00000285873	02-Medium	0.19	3.80	G2	C2	—	—	—	9	25
WNT4	02-Medium	0.18	3.27	G2	C2	—	FIB.reticular.stress_metallothionein (Tier: relevant)	34 cells — complete matches	4	7
ENSG00000289694	02-Medium	0.18	3.35	G2	C2	—	—	—	18	33
CDC42-AS1	02-Medium	0.17	2.96	G2	C2	—	—	—	9	25
ENSG00000294752	02-Medium	0.17	3.91	G2	C2	—	—	—	1	1
C1QC	02-Medium	0.14	3.16	G2	C2	macrophage (L1), MAC.resident_cardiac (L1S), MAC.resident_repair (L1S), MAC.LAM.inflammatory_APC (L2), MAC.MDM.complement_resolving (L2), MAC.kupffer.tolerogenic (L2), MG.phagocytic_APC (L2), MONO.CD16.hepatic_mac_like (L2)	—	67 cells — complete matches	1	1
CDC42-IT1	02-Medium	0.13	3.17	G2	C2	—	—	—	8	24

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.