Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000041 · All tissues

Adenocarcinoma, papilloma adenocarcinoma and mucinous carcinomas of rectum, excluding all cancers (controls excluding all cancers): evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Cancer, Colorectal

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	epithelial_cell	4.33	Nominal	2.47e-47	1.18	Other	24	47
2	mesothelial_cell	2.81	Nonsignificant	1.00	1.06	Other	6	36
3	melanocyte	2.61	Nonsignificant	1.00	1.07	Other	97	309
4	adipose_stem_and_progenitor_cell	2.33	Nonsignificant	1.19e-08	1.11	Other	327	954
5	fibroblast	1.56	Nonsignificant	0.44	1.03	Other	184	826
6	granulosa_cell	0.73	Nonsignificant	1.00	0.92	Other	293	670
7	pericyte	0.70	Nonsignificant	1.00	0.99	Other	128	517
8	haematopoietic_progenitor_cell	0.61	Nonsignificant	1.00	0.90	Other	262	502
9	plasma_cell	0.59	Nonsignificant	1.00	0.96	Other	17	24
10	schwann_cell	0.50	Nonsignificant	1.00	0.97	Other	10	57
11	induced_pluripotent_stem_cell	0.29	Nonsignificant	1.00	0.91	Other	0	0
12	adipocyte	0.24	Nonsignificant	1.00	0.85	Other	33	111
13	smooth_muscle_cell	0.24	Nonsignificant	1.00	0.89	Other	27	139
14	muscle_stem_cell	0.21	Nonsignificant	1.00	0.83	Other	7	27
15	endothelial_cell	0.20	Nonsignificant	1.00	0.87	Other	373	974
16	chondrocyte	0.18	Nonsignificant	1.00	0.83	Other	548	1,069
17	microglia	0.18	Nonsignificant	1.00	0.85	Other	61	129
18	granulocyte	0.08	Nonsignificant	1.00	0.81	Other	5	6
19	B_cell	0.08	Nonsignificant	1.00	0.81	Other	356	694
20	innate_lymphoid_cell_2	0.06	Nonsignificant	1.00	0.81	Other	3	8
21	thymocyte	0.06	Nonsignificant	1.00	0.80	Other	168	512
22	macrophage	0.01	Nonsignificant	1.00	0.73	Other	813	1,732
23	T_cell	9.95e-03	Nonsignificant	1.00	0.62	Other	470	959
24	platelet	8.99e-03	Nonsignificant	—	0.00	Other	85	104
25	astrocyte	8.50e-03	Nonsignificant	1.00	0.70	Other	256	1,203
26	dendritic_cell	4.73e-03	Nonsignificant	1.00	0.71	Other	496	724
27	neuron	2.24e-03	Nonsignificant	1.00	0.71	Other	330	1,328
28	hepatocyte	1.31e-03	Nonsignificant	1.00	0.67	Other	1,515	3,822
29	monocyte	1.04e-03	Nonsignificant	1.00	0.66	Other	2,176	3,871
30	cardiomyocyte	9.44e-04	Nonsignificant	1.00	0.71	Other	533	2,045
31	natural_killer_cell	5.28e-04	Nonsignificant	1.00	0.54	Other	1,204	2,052
32	oligodendrocyte_precursor_cell	2.97e-04	Nonsignificant	1.00	0.57	Other	461	1,454
33	oligodendrocyte	2.37e-04	Nonsignificant	1.00	0.52	Other	385	1,507
34	skeletal_muscle_cell	9.42e-06	Nonsignificant	1.00	0.30	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.thymic_cortical	35.27	Significant	1.43e-08	1.79	Specific	442	824
2	EPI.intrahepatic_cholangiocyte_transport	24.85	Significant	—	2.02	Specific	12	42
3	EPI.salivary_duct_excretory	18.13	Significant	1.27e-03	1.59	Specific	85	180
4	EPI.pancreatic_ductal_progenitor	14.13	Significant	2.60e-04	1.57	Specific	234	873
5	EPI.ileal_enterocyte_crypt	11.26	Significant	0.03	1.38	Specific	67	113
6	EPI.salivary_duct_ion_transport	10.24	Significant	0.35	1.40	Relevant	5	11
7	EPI.extrahepatic_cholangiocyte	9.76	Significant	—	1.03	Relevant	37	71
8	EPI.pancreatic_ductal_perivascular	9.70	Significant	0.42	1.26	Relevant	4	30
9	EPI.pancreatic_ductal_bicarbonate	9.34	Significant	0.02	1.33	Specific	131	548
10	EPI.bile_duct_cholangiocyte	9.10	Significant	0.51	1.28	Relevant	37	60
11	EPI.salivary_intercalated_defense	9.01	Significant	0.04	1.39	Specific	81	161
12	EPI.colonocyte	8.42	Significant	2.60e-04	1.41	Specific	294	815
13	EPI.intrahepatic_cholangiocyte_defense	8.04	Significant	—	0.91	Relevant	8	13
14	EPI.ileal_goblet	7.51	Significant	0.15	1.33	Relevant	181	432
15	EPI.hepatic_ductular_cholangiocyte	6.62	Significant	0.51	1.20	Relevant	83	243
16	FIB.suburothelial	5.90	Significant	1.97e-10	2.23	Specific	122	432
17	EPI.alveolar_type_2	5.74	Significant	0.56	1.11	Other	813	1,853
18	EPI.pancreatic_ductal_mucinous	5.07	Nominal	1.00	1.01	Other	219	430
19	EPI.renal_distal_tubule	5.05	Nominal	1.00	1.07	Other	133	361
20	EPI.ileal_bile_transport	3.98	Nominal	0.79	1.13	Other	61	93
21	EPI.salivary_serous_acinar	3.34	Nominal	1.00	0.86	Other	233	531
22	EPI.cervical_suprabasal	3.21	Nominal	—	0.29	Other	14	50
23	EPI.colonic_tuft	3.01	Nominal	—	0.26	Other	7	24
24	EPI.tracheal_suprabasal	2.81	Nonsignificant	1.00	0.66	Other	29	56
25	MESO.mesothelial_cell	2.81	Nonsignificant	—	—	Other	2	18
26	EPI.renal_immature_ureteric_bud	2.64	Nonsignificant	1.00	0.71	Other	217	569
27	MEL.melanocyte	2.61	Nonsignificant	—	—	Other	79	242
28	EPI.lung_multiciliated	2.54	Nonsignificant	1.00	0.70	Other	16	49
29	EPI.skin_hair_follicle_bulge	2.52	Nonsignificant	1.00	0.75	Other	51	178
30	EPI.renal_principal_cell	2.41	Nonsignificant	1.00	0.70	Other	207	403
31	ASPC.adipose_stem_and_progenitor_cell	2.33	Nonsignificant	—	—	Other	324	930
32	EPI.pancreatic_acinar	2.18	Nonsignificant	1.00	0.70	Other	429	1,475
33	FIB.barrier_purinergic	2.15	Nonsignificant	—	0.29	Other	1	3
34	FIB.tracheal_subepithelial	2.07	Nonsignificant	—	0.63	Other	0	0
35	FIB.reticular	2.00	Nonsignificant	0.57	1.30	Other	19	87
36	FIB.skin_papillary	1.91	Nonsignificant	—	0.64	Other	0	0
37	EPI.renal_intercalated_cell_type_A	1.91	Nonsignificant	1.00	0.67	Other	67	142
38	EPI.skin_hair_follicle_companion	1.78	Nonsignificant	—	0.00	Other	8	12
39	EPI.ileal_enterocyte_absorptive	1.75	Nonsignificant	1.00	0.68	Other	118	338
40	EPI.gastric_foveolar	1.72	Nonsignificant	—	0.00	Other	0	0
41	FIB.interstitial	1.56	Nonsignificant	0.97	0.91	Other	288	940
42	EPI.lung_club_secretory	1.51	Nonsignificant	1.00	0.45	Other	5	14
43	FIB.neurolectin_mucosa	1.38	Nonsignificant	0.97	0.99	Other	133	394
44	FIB.skin_tenogenic	1.37	Nonsignificant	—	0.22	Other	108	227
45	FIB.adventitial	1.35	Nonsignificant	0.97	0.81	Other	268	1,447
46	EPI.tracheal_basal	1.32	Nonsignificant	1.00	0.61	Other	398	1,120
47	EPI.renal_intercalated_cell_type_B	1.23	Nonsignificant	—	0.00	Other	6	7
48	FIB.perivascular_interface	1.13	Nonsignificant	0.97	0.47	Other	0	0
49	EPI.renal_thick_ascending_limb	1.11	Nonsignificant	1.00	0.30	Other	453	1,153
50	FIB.barrier_secretory	1.07	Nonsignificant	0.57	1.35	Other	81	228
51	EPI.alveolar_type_1	0.94	Nonsignificant	1.00	0.48	Other	26	101
52	EPI.thymic_medullary	0.94	Nonsignificant	1.00	0.45	Other	26	133
53	EPI.endocervical_secretory	0.93	Nonsignificant	—	0.00	Other	0	0
54	EPI.esophageal_suprabasal	0.93	Nonsignificant	1.00	0.50	Other	158	404
55	EPI.colonic_enteroendocrine	0.84	Nonsignificant	—	0.00	Other	1	1
56	EPI.pancreatic_islet	0.83	Nonsignificant	1.00	0.56	Other	52	132
57	EPI.skin_keratinocyte_progenitor	0.79	Nonsignificant	—	0.00	Other	0	3
58	GRNLSA.granulosa_cell	0.73	Nonsignificant	—	—	Other	257	0
59	FIB.hepatic_stellate_cell	0.71	Nonsignificant	—	0.00	Other	64	252
60	PERI.pericyte	0.70	Nonsignificant	—	—	Other	117	0
61	FIB.skin_sheath	0.69	Nonsignificant	0.97	0.30	Other	49	118
62	FIB.skin_neurosecretory	0.67	Nonsignificant	—	0.00	Other	0	0
63	PC.IgA_muocsal	0.62	Nonsignificant	2.56e-03	1.72	Other	18	31
64	FIB.transitioning	0.62	Nonsignificant	0.97	0.60	Other	172	497
65	EPI.tracheal_submucosal_gland	0.61	Nonsignificant	—	0.00	Other	0	0
66	HPC.haematopoietic_progenitor_cell	0.61	Nonsignificant	—	—	Other	211	370
67	EPI.ectocervical_granular	0.53	Nonsignificant	—	0.00	Other	11	23
68	EPI.renal_proximal_tubule	0.50	Nonsignificant	1.00	0.33	Other	525	806
69	SCHWN.schwann_cell	0.50	Nonsignificant	—	—	Other	7	33
70	EC.capillary	0.45	Nonsignificant	4.20e-25	1.40	Other	514	1,635
71	EPI.skin_sebaceous_duct_luminal	0.44	Nonsignificant	1.00	0.23	Other	100	249
72	EPI.esophageal_basal	0.37	Nonsignificant	1.00	0.30	Other	4	10
73	PC.IgG_systemic	0.36	Nonsignificant	0.90	0.69	Other	41	60
74	MAC.microglia_like	0.36	Nonsignificant	0.77	1.20	Other	124	179
75	EPI.salivary_myoepithelial	0.35	Nonsignificant	1.00	0.16	Other	191	714
76	IPSC.induced_pluripotent_stem_cell	0.29	Nonsignificant	—	—	Other	0	0
77	EPI.skin_keratinocyte_basal	0.28	Nonsignificant	—	0.00	Other	13	26
78	B.germinal_center	0.26	Nonsignificant	0.11	1.37	Other	233	655
79	ADIPO.adipocyte	0.24	Nonsignificant	—	—	Other	20	62
80	SMC.smooth_muscle_cell	0.24	Nonsignificant	—	—	Other	20	101
81	EPI.salivary_mucous_acinar	0.22	Nonsignificant	1.00	0.21	Other	639	1,189
82	MUSC.muscle_stem_cell	0.21	Nonsignificant	—	—	Other	4	18
83	EPI.skin_follicular_keratinizing	0.18	Nonsignificant	1.00	0.11	Other	30	81
84	CHOND.chondrocyte	0.18	Nonsignificant	—	—	Other	519	730
85	MG.microglia	0.18	Nonsignificant	—	—	Other	49	0
86	FIB.lung_alveolar	0.17	Nonsignificant	—	0.00	Other	6	15
87	EC.venous	0.15	Nonsignificant	1.00	0.88	Other	516	1,387
88	EPI.skin_sweat_duct_keratinocyte	0.14	Nonsignificant	1.00	0.08	Other	146	301
89	B.naive	0.13	Nonsignificant	7.72e-17	1.49	Other	307	595
90	GRANU.MAST	0.13	Nonsignificant	8.70e-04	1.51	Other	5	6
91	EPI.skin_keratinocyte_proliferating	0.13	Nonsignificant	1.00	0.15	Other	47	76
92	T.CD4_Tfh	0.11	Nonsignificant	0.80	1.12	Other	47	45
93	EC.arterial	0.09	Nonsignificant	1.00	0.88	Other	356	885
94	EPI.skin_appendage_keratinocyte	0.09	Nonsignificant	1.00	0.11	Other	87	222
95	T.CD4_Th2	0.07	Nonsignificant	—	1.84	Other	1	2
96	ILC2.innate_lymphoid_cell_2	0.06	Nonsignificant	—	—	Other	2	0
97	MAC.resident_iron	0.06	Nonsignificant	0.77	1.09	Other	16	21
98	THYMO.thymocyte	0.06	Nonsignificant	—	—	Other	163	495
99	T.CD4_Trm	0.05	Nonsignificant	0.80	1.07	Other	176	363
100	HEP.pericentral_lipoprotein	0.04	Nonsignificant	—	2.50	Other	0	0
101	B.memory	0.02	Nonsignificant	1.00	0.17	Other	442	882
102	T.CD8_naive	0.02	Nonsignificant	0.80	1.06	Other	317	708
103	MAC.proliferating	0.02	Nonsignificant	1.00	1.06	Other	87	253
104	T.CD8_Trm	0.01	Nonsignificant	1.00	0.99	Other	211	346
105	T.CD4_Tem	0.01	Nonsignificant	0.80	1.05	Other	365	697
106	NEU.INH_VIP	0.01	Nonsignificant	0.26	1.06	Other	241	366
107	T.CD4_transitional	9.58e-03	Nonsignificant	0.93	1.02	Other	48	110
108	PLAT.platelet	8.99e-03	Nonsignificant	—	0.00	Other	38	53
109	ASTRO.astrocyte	8.50e-03	Nonsignificant	—	—	Other	228	1,111
110	DC.cDC2	6.12e-03	Nonsignificant	0.06	1.14	Other	1,189	1,793
111	MAC.kupffer	5.74e-03	Nonsignificant	1.00	1.00	Other	189	530
112	MAC.MDM	4.80e-03	Nonsignificant	1.00	0.89	Other	623	986
113	MAC.LAM	4.72e-03	Nonsignificant	1.00	0.89	Other	914	2,064
114	T.CD8_Tcm	3.98e-03	Nonsignificant	0.80	1.04	Other	460	926
115	T.CD4_naive	3.84e-03	Nonsignificant	1.00	0.92	Other	399	866
116	T.CD4_Treg	3.81e-03	Nonsignificant	0.80	1.05	Other	244	511
117	EC.lymphatic	3.22e-03	Nonsignificant	1.00	0.39	Other	630	998
118	DC.mig	2.94e-03	Nonsignificant	—	0.48	Other	89	156
119	T.CD4_Tcm	2.88e-03	Nonsignificant	1.00	0.99	Other	494	988
120	T.CD8_transitional	2.61e-03	Nonsignificant	1.00	0.95	Other	497	932
121	EC.heart_remodeling	2.34e-03	Nonsignificant	1.00	0.23	Other	569	1,594
122	T.CD4_Th17	2.16e-03	Nonsignificant	1.00	0.96	Other	421	794
123	DC.cDC1	1.97e-03	Nonsignificant	1.00	0.94	Other	55	112
124	B.age_associated	1.77e-03	Nonsignificant	1.00	0.22	Other	207	350
125	HEP.canalicular_transport	1.58e-03	Nonsignificant	0.28	1.03	Other	1,290	3,434
126	HEP.periportal_metabolic	1.57e-03	Nonsignificant	0.28	1.03	Other	1,750	4,427
127	EC.liver_sinusoidal	1.40e-03	Nonsignificant	1.00	0.30	Other	1,083	1,925
128	NEU.INH_PVALB	1.36e-03	Nonsignificant	0.93	0.99	Other	193	183
129	MAC.resident_cardiac	1.11e-03	Nonsignificant	1.00	0.71	Other	485	1,074
130	MONO.CD14	1.06e-03	Nonsignificant	0.78	0.99	Other	2,294	4,139
131	CM.cardiomyocyte	9.44e-04	Nonsignificant	—	—	Other	524	2,032
132	T.MAIT	9.36e-04	Nonsignificant	1.00	0.82	Other	469	855
133	MONO.CD16	9.22e-04	Nonsignificant	0.78	1.01	Other	1,304	1,835
134	T.CD8_Tem	8.18e-04	Nonsignificant	1.00	0.94	Other	1,083	1,857
135	GRANU.neutrophil	6.63e-04	Nonsignificant	1.00	0.00	Other	1,235	2,649
136	NEU.EXC_IT	5.52e-04	Nonsignificant	0.11	1.06	Other	411	192
137	NK.natural_killer_cell	5.28e-04	Nonsignificant	—	—	Other	1,204	2,045
138	MAC.resident_repair	4.18e-04	Nonsignificant	1.00	0.74	Other	796	1,426
139	T.gamma_delta	3.35e-04	Nonsignificant	1.00	0.70	Other	588	1,078
140	OPC.oligodendrocyte_precursor_cell	2.97e-04	Nonsignificant	—	—	Other	413	1,269
141	EPI.skin_interfollicular_spinous	2.71e-04	Nonsignificant	1.00	1.36e-03	Other	260	563
142	OLG.oligodendrocyte	2.37e-04	Nonsignificant	—	—	Other	384	1,397
143	T.CD4_cytotoxic	1.42e-04	Nonsignificant	1.00	0.74	Other	855	1,493
144	NEU.EXC_SYT2	9.03e-05	Nonsignificant	—	0.00	Other	40	77
145	NEU.INH_LAMP5	2.44e-05	Nonsignificant	0.93	0.75	Other	263	532
146	SKM.type_1_slow	1.79e-05	Nonsignificant	0.09	1.09	Other	923	2,478
147	NEU.EXC_CT	4.81e-06	Nonsignificant	0.93	0.81	Other	362	384
148	HEP.acute_phase	4.59e-06	Nonsignificant	1.00	0.69	Other	1,441	3,641
149	MAC.alveolar	3.90e-06	Nonsignificant	1.00	0.30	Other	1,432	3,122
150	SKM.type_2_fast	3.14e-06	Nonsignificant	0.95	0.88	Other	972	2,639
151	DC.pDC	3.02e-06	Nonsignificant	1.00	0.25	Other	496	1,028
152	NEU.EXC_NTNG1	1.60e-10	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.thymic_cortical.baseline	40.34	Significant	0.07	1.81	Specific	185	386
2	EPI.thymic_cortical.Notch_interface	36.31	Significant	—	0.00	Specific	82	137
3	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	35.60	Significant	—	1.15	—	0	0
4	EPI.thymic_cortical.secretory_remodeling	24.72	Significant	—	0.00	—	4	1
5	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	23.35	Significant	—	0.32	—	0	0
6	EPI.salivary_duct_excretory.stress	20.75	Significant	0.58	0.92	Relevant	33	68
7	EPI.pancreatic_ductal_progenitor.ciliated_transport	19.57	Significant	—	1.22	Relevant	105	368
8	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	18.44	Significant	—	0.00	—	0	0
9	EPI.salivary_duct_excretory.baseline	16.96	Significant	0.58	0.87	Relevant	23	57
10	EPI.salivary_intercalated_defense.inflammatory	15.10	Significant	0.02	1.61	Specific	152	360
11	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	14.59	Significant	—	1.13	Relevant	49	237
12	EPI.ileal_enterocyte_crypt.proliferative_G2M	14.45	Significant	—	0.66	—	19	54
13	EPI.pancreatic_ductal_progenitor.baseline	14.26	Significant	0.10	1.65	Relevant	179	702
14	EPI.salivary_serous_acinar.quiescent	14.01	Significant	1.21e-11	2.36	Specific	178	493
15	EPI.salivary_intercalated_defense.basal_EMT	13.52	Significant	—	0.67	—	0	0
16	EPI.ileal_enterocyte_crypt.baseline	13.12	Significant	0.52	1.26	—	11	6
17	EPI.ileal_enterocyte_crypt.proliferative_S	12.85	Significant	0.52	1.17	—	4	2
18	EPI.pancreatic_ductal_bicarbonate.inflammatory	12.08	Significant	0.15	1.75	Relevant	14	32
19	EPI.pancreatic_ductal_perivascular.protective_antioxidant	12.03	Significant	—	0.63	Relevant	11	69
20	EPI.hepatic_ductular_cholangiocyte.ion_transport	12.00	Significant	—	1.86	Relevant	0	0
21	EPI.bile_duct_cholangiocyte.inflammatory_APC	11.78	Significant	—	0.76	—	2	0
22	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	11.75	Significant	—	1.44	Relevant	0	0
23	EPI.colonocyte.secretory_boost	11.66	Significant	0.10	1.93	—	98	91
24	EPI.extrahepatic_cholangiocyte.mucin_secretory	11.17	Significant	—	0.00	Relevant	0	0
25	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	10.86	Significant	—	0.00	—	0	0
26	EPI.ileal_enterocyte_crypt.secretory_precursor	10.73	Significant	—	0.00	—	0	0
27	EPI.pancreatic_ductal_bicarbonate.activated	10.28	Significant	0.49	1.26	—	10	7
28	EPI.salivary_duct_ion_transport.baseline	10.24	Significant	—	—	—	0	0
29	EPI.colonocyte.junction_remodeling	9.95	Significant	0.10	1.76	—	218	305
30	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	9.88	Significant	0.49	1.17	Relevant	219	533
31	EPI.hepatic_ductular_cholangiocyte.secretory_transport	9.01	Significant	—	0.54	—	0	0
32	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	8.89	Significant	—	0.73	—	0	0
33	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	8.83	Significant	0.49	1.06	Relevant	40	191
34	EPI.pancreatic_ductal_bicarbonate.baseline	8.48	Significant	0.49	1.00	Relevant	11	42
35	EPI.ileal_goblet.stress_metallothionein	8.46	Significant	—	0.56	Relevant	4	11
36	EPI.hepatic_ductular_cholangiocyte.polarity	8.38	Significant	—	0.41	—	0	0
37	EPI.colonocyte.crypt_progenitor	8.34	Significant	0.30	1.36	Relevant	115	265
38	EPI.alveolar_type_2.injury_primed	8.33	Significant	6.29e-04	2.15	Specific	434	245
39	EPI.ileal_goblet.inflammatory_mucin	8.30	Significant	0.65	1.20	Relevant	6	9
40	EPI.renal_distal_tubule.ion_transport	8.25	Significant	—	0.53	Relevant	0	0
41	EPI.extrahepatic_cholangiocyte.barrier_interface	8.25	Significant	—	0.00	Relevant	0	0
42	EPI.pancreatic_ductal_perivascular.baseline	8.22	Significant	0.92	0.25	Relevant	1	5
43	EPI.pancreatic_ductal_progenitor.ADM_like	8.04	Significant	—	0.00	—	0	0
44	EPI.ileal_enterocyte_crypt.bile_transport	8.02	Significant	0.91	0.46	—	2	0
45	EPI.colonocyte.goblet_interface	7.92	Significant	—	0.00	Relevant	11	21
46	MESO.activated_stress	7.89	Significant	—	1.24	Relevant	0	0
47	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	7.77	Significant	—	0.44	—	6	9
48	EPI.colonocyte.proximal_transport	7.29	Significant	0.94	0.42	—	24	12
49	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	7.07	Significant	—	0.00	Relevant	0	0
50	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	7.07	Significant	—	0.35	—	0	0
51	EPI.ileal_goblet.baseline	7.04	Significant	0.86	0.36	—	16	2
52	EPI.renal_distal_tubule.repair	7.02	Significant	—	0.55	Relevant	34	102
53	FIB.suburothelial.homeostasis_matrix	6.84	Significant	0.04	2.25	Relevant	258	921
54	FIB.suburothelial.contractile_myofibroblast	6.32	Significant	—	0.31	—	9	0
55	EPI.colonocyte.ionocyte_BEST4	6.30	Significant	0.94	0.30	—	103	188
56	EPI.bile_duct_cholangiocyte.secretory_mucin	6.26	Significant	—	0.00	Relevant	7	12
57	FIB.suburothelial.inflammatory_prostanoid	5.51	Significant	—	0.00	Relevant	0	0
58	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	5.51	Significant	—	0.00	Relevant	0	0
59	EPI.ileal_goblet.immature	5.18	Nominal	—	0.00	Relevant	0	0
60	FIB.suburothelial.urothelial_interface	4.99	Nominal	1.00	0.00	Other	9	8
61	EPI.pancreatic_ductal_bicarbonate.stress	4.96	Nominal	—	0.00	Other	12	33
62	EPI.ileal_enterocyte_crypt.villus_transition	4.69	Nominal	—	0.00	Other	7	10
63	EPI.renal_distal_tubule.stress	4.68	Nominal	—	0.00	Other	0	0
64	EPI.alveolar_type_2.stress_response	4.64	Nominal	0.99	0.31	Other	675	1,562
65	EPI.ileal_bile_transport.detox_transcytosis	4.61	Nominal	—	1.18	Other	0	1
66	EPI.pancreatic_acinar.metabolic_onecarbon	4.57	Nominal	2.84e-06	1.75	Other	287	328
67	EPI.skin_hair_follicle_bulge.anagen_growth	4.55	Nominal	—	1.80	Other	0	0
68	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	4.42	Nominal	—	0.00	Other	0	0
69	EPI.lung_club_secretory.ciliogenesis_axoneme	4.33	Nominal	—	1.13	Other	0	0
70	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	4.27	Nominal	0.75	0.70	Other	449	1,034
71	EPI.alveolar_type_2.baseline_surfactant	3.99	Nominal	0.99	0.19	Other	64	9
72	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.95	Nominal	—	0.00	Other	5	3
73	EPI.renal_thick_ascending_limb.barrier_repair	3.89	Nominal	2.95e-03	1.56	Other	141	284
74	EPI.ileal_bile_transport.absorptive_xenobiotic	3.76	Nominal	1.00	0.00	Other	11	12
75	FIB.barrier_purinergic.stress_GF_binding	3.67	Nominal	—	0.97	Other	0	0
76	EPI.colonic_tuft.homeostatic	3.47	Nominal	—	0.73	Other	0	0
77	EPI.cervical_suprabasal.inflammatory_repair	3.33	Nominal	—	0.00	Other	0	0
78	EPI.salivary_serous_acinar.seromucous_like	3.33	Nominal	—	0.48	Other	0	0
79	EPI.tracheal_suprabasal.secretory_immune	3.23	Nominal	—	0.00	Other	0	0
80	EPI.pancreatic_acinar.adhesion_remodeling	3.21	Nominal	0.80	1.13	Other	210	784
81	EPI.lung_multiciliated.stress	3.18	Nominal	—	0.77	Other	67	165
82	EPI.renal_principal_cell.canonical_vasopressin	3.12	Nominal	0.85	1.25	Other	2	0
83	EPI.cervical_suprabasal.secretory_vesicle	3.08	Nominal	—	0.00	Other	0	0
84	MEL.mature_oxidative_traffic	3.00	Nonsignificant	0.16	1.48	Other	247	285
85	EPI.renal_immature_ureteric_bud.defense_secretory	2.94	Nonsignificant	0.35	1.39	Other	45	76
86	EPI.salivary_intercalated_defense.canonical_antimicrobial	2.93	Nonsignificant	1.00	0.00	Other	11	22
87	MEL.secretory_quiescent	2.89	Nonsignificant	0.16	1.49	Other	19	13
88	ASPC.baseline	2.84	Nonsignificant	5.79e-03	1.45	Other	363	170
89	EPI.renal_intercalated_cell_type_A.PC_transitional	2.75	Nonsignificant	—	1.22	Other	203	407
90	MESO.secretory_structural	2.70	Nonsignificant	—	0.10	Other	0	0
91	ASPC.mesothelial_like	2.70	Nonsignificant	0.45	1.41	Other	143	486
92	EPI.hepatic_ductular_cholangiocyte.stress	2.67	Nonsignificant	—	0.00	Other	0	0
93	ASPC.adipocyte_capillary_interface	2.65	Nonsignificant	0.80	1.15	Other	21	54
94	EPI.renal_principal_cell.injury_repair	2.58	Nonsignificant	0.85	1.03	Other	26	9
95	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	2.57	Nonsignificant	—	0.00	Other	0	0
96	EPI.colonic_tuft.activated	2.56	Nonsignificant	—	0.00	Other	0	0
97	EPI.skin_hair_follicle_bulge.quiescent	2.54	Nonsignificant	0.18	1.52	Other	56	69
98	EPI.renal_immature_ureteric_bud.osmoprotective	2.54	Nonsignificant	0.71	0.81	Other	126	44
99	ASPC.remodeling	2.53	Nonsignificant	0.96	0.99	Other	106	354
100	EPI.tracheal_suprabasal.transitional_wound	2.51	Nonsignificant	—	0.00	Other	16	1
101	ASPC.secretory	2.51	Nonsignificant	1.00	0.94	Other	76	5
102	FIB.interstitial.remodeling	2.48	Nonsignificant	0.02	1.57	Other	31	9
103	EPI.salivary_serous_acinar.secretory_active	2.44	Nonsignificant	1.00	0.00	Other	242	69
104	EPI.colonocyte.distal_absorptive	2.43	Nonsignificant	—	0.00	Other	0	0
105	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.40	Nonsignificant	—	0.00	Other	0	0
106	FIB.reticular.immune_interface	2.40	Nonsignificant	—	0.31	Other	1	6
107	MESO.antiviral	2.39	Nonsignificant	—	0.00	Other	3	8
108	EPI.renal_distal_tubule.immune_modulatory	2.37	Nonsignificant	—	0.00	Other	0	0
109	MEL.dedifferentiated_migratory	2.35	Nonsignificant	—	0.00	Other	0	0
110	ASPC.preadipocyte_lipid_primed	2.32	Nonsignificant	0.45	1.19	Other	331	129
111	EPI.renal_principal_cell.intercalated_like	2.28	Nonsignificant	0.85	0.98	Other	63	66
112	GRNLSA.EMT_insulin_signaling	2.24	Nonsignificant	5.85e-04	1.96	Other	47	84
113	EPI.renal_principal_cell.inflammatory	2.16	Nonsignificant	0.85	0.55	Other	74	157
114	FIB.adventitial.mechano_chemo_sensing	2.14	Nonsignificant	1.02e-03	1.73	Other	135	524
115	MEL.stress_glucocorticoid	2.12	Nonsignificant	0.76	0.71	Other	11	34
116	FIB.interstitial.mesenchymal_regulator	2.09	Nonsignificant	0.34	1.36	Other	4	4
117	FIB.tracheal_subepithelial.baseline	2.07	Nonsignificant	—	0.00	Other	0	0
118	EPI.lung_multiciliated.baseline	2.06	Nonsignificant	—	0.00	Other	0	7
119	EPI.renal_principal_cell.activated_acute	2.04	Nonsignificant	0.85	0.72	Other	29	59
120	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	1.97	Nonsignificant	—	0.97	Other	0	0
121	FIB.interstitial.stress_secretory	1.96	Nonsignificant	0.43	1.28	Other	92	56
122	ASPC.activated	1.95	Nonsignificant	1.00	0.66	Other	164	162
123	EPI.pancreatic_islet.alpha	1.93	Nonsignificant	—	0.94	Other	152	330
124	FIB.skin_papillary.baseline	1.91	Nonsignificant	—	0.00	Other	0	0
125	FIB.reticular.ECM_builder	1.90	Nonsignificant	—	0.29	Other	0	0
126	FIB.reticular.stromal_niche	1.89	Nonsignificant	0.85	0.56	Other	0	0
127	EPI.skin_hair_follicle_companion.activated_migratory	1.88	Nonsignificant	—	0.00	Other	0	0
128	EPI.ileal_enterocyte_absorptive.brush_border	1.88	Nonsignificant	0.81	1.11	Other	580	1,717
129	ASPC.proliferative	1.86	Nonsignificant	0.89	1.09	Other	33	85
130	MESO.baseline	1.85	Nonsignificant	0.82	0.67	Other	0	6
131	FIB.reticular.stress_metallothionein	1.84	Nonsignificant	—	0.03	Other	3	32
132	FIB.perivascular_interface.lipid_shuttle	1.81	Nonsignificant	—	0.97	Other	51	170
133	FIB.adventitial.complement_angiocrine	1.74	Nonsignificant	0.07	1.38	Other	153	684
134	EPI.gastric_foveolar.baseline	1.72	Nonsignificant	—	0.00	Other	0	0
135	EPI.renal_intercalated_cell_type_A.acid_secretion	1.67	Nonsignificant	1.00	0.00	Other	12	6
136	ASPC.inflammatory	1.65	Nonsignificant	1.00	0.55	Other	21	61
137	EPI.ileal_enterocyte_absorptive.villus_tip	1.63	Nonsignificant	0.87	0.53	Other	4	3
138	FIB.neurolectin_mucosa.inflammatory	1.62	Nonsignificant	0.63	1.23	Other	52	110
139	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.55	Nonsignificant	—	0.00	Other	29	88
140	FIB.interstitial.mesenchymal_APC	1.50	Nonsignificant	0.74	1.01	Other	81	33
141	EPI.pancreatic_acinar.quiet_dedifferentiation	1.49	Nonsignificant	1.00	0.74	Other	142	171
142	SCHWN.reactive_inflammatory	1.48	Nonsignificant	—	1.14	Other	0	0
143	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.48	Nonsignificant	—	0.00	Other	0	0
144	EPI.esophageal_suprabasal.proliferative_G2M	1.44	Nonsignificant	—	1.61	Other	0	0
145	FIB.adventitial.baseline	1.44	Nonsignificant	0.93	0.98	Other	157	278
146	FIB.adventitial.adhesion_lipid	1.43	Nonsignificant	0.35	1.25	Other	58	209
147	FIB.adventitial.mito_secretory	1.37	Nonsignificant	0.97	0.84	Other	21	7
148	FIB.skin_tenogenic.baseline	1.37	Nonsignificant	—	0.00	Other	0	2
149	FIB.neurolectin_mucosa.nerve_interface	1.36	Nonsignificant	—	0.00	Other	4	0
150	EPI.tracheal_basal.activated_stress	1.35	Nonsignificant	0.58	1.31	Other	32	0
151	MESO.activated_migratory	1.35	Nonsignificant	—	0.00	Other	0	0
152	FIB.interstitial.immune_interact	1.34	Nonsignificant	0.90	0.85	Other	12	1
153	FIB.neurolectin_mucosa.remodeling_repair	1.31	Nonsignificant	—	0.00	Other	4	2
154	EPI.tracheal_basal.homeostatic_progenitor	1.30	Nonsignificant	0.82	0.45	Other	285	74
155	EPI.lung_multiciliated.mature_motile_cilia	1.27	Nonsignificant	—	0.00	Other	0	0
156	FIB.neurolectin_mucosa.axon_responsive	1.25	Nonsignificant	0.91	0.41	Other	10	10
157	EPI.renal_intercalated_cell_type_B.baseline	1.23	Nonsignificant	—	0.00	Other	3	1
158	EPI.esophageal_suprabasal.proliferative_exit	1.22	Nonsignificant	—	0.99	Other	0	0
159	EPI.pancreatic_acinar.inflammatory_regenerative	1.19	Nonsignificant	1.00	1.00	Other	25	113
160	HPC.LMPP	1.18	Nonsignificant	0.19	1.35	Other	65	31
161	ASPC.niche_keeping_progenitor	1.17	Nonsignificant	1.00	0.14	Other	52	219
162	EPI.esophageal_suprabasal.proliferative_S	1.15	Nonsignificant	—	0.88	Other	26	41
163	EPI.thymic_medullary.proliferative_APC	1.10	Nonsignificant	—	0.72	Other	0	0
164	IPSC.neuroendocrine_primed	1.09	Nonsignificant	—	1.90	Other	0	0
165	FIB.barrier_secretory.remodeling	1.08	Nonsignificant	—	0.00	Other	0	0
166	EPI.skin_keratinocyte_progenitor.activated_stress	1.07	Nonsignificant	—	0.38	Other	0	0
167	FIB.barrier_secretory.homeostasis	1.06	Nonsignificant	—	0.25	Other	0	0
168	EPI.thymic_medullary.canonical_alarmin	1.05	Nonsignificant	0.47	1.21	Other	8	17
169	MAC.microglia_like.patrolling_adhesive	1.05	Nonsignificant	—	1.21	Other	0	0
170	EPI.ectocervical_granular.proliferative_basal	1.04	Nonsignificant	—	1.15	Other	0	0
171	FIB.transitioning.matrix_stress	1.04	Nonsignificant	—	0.70	Other	47	138
172	EPI.endocervical_secretory.secretory_translocon	1.02	Nonsignificant	—	0.67	Other	0	0
173	EPI.renal_thick_ascending_limb.salt_sensing	1.02	Nonsignificant	1.00	1.04	Other	73	103
174	EPI.alveolar_type_1.baseline	1.00	Nonsignificant	0.09	1.79	Other	8	0
175	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.99	Nonsignificant	—	0.97	Other	0	0
176	EPI.lung_club_secretory.canonical_surfactant	0.99	Nonsignificant	—	0.00	Other	74	104
177	GRNLSA.p53_damage	0.98	Nonsignificant	—	0.61	Other	13	10
178	EPI.thymic_medullary.stress_APC	0.96	Nonsignificant	0.47	1.10	Other	2	4
179	FIB.adventitial.inflammatory_activated	0.95	Nonsignificant	1.00	0.74	Other	100	473
180	EPI.tracheal_submucosal_gland.ductal_luminal	0.92	Nonsignificant	—	0.73	Other	0	0
181	EPI.colonic_enteroendocrine.Lcell_peptide	0.92	Nonsignificant	—	0.00	Other	0	0
182	FIB.barrier_purinergic.lipid_secretory	0.92	Nonsignificant	—	0.00	Other	0	0
183	HPC.GMP_granulocytic	0.92	Nonsignificant	—	0.29	Other	3	3
184	GRNLSA.stress_metabolic	0.91	Nonsignificant	—	0.41	Other	1	2
185	EPI.esophageal_suprabasal.basal_transitional	0.89	Nonsignificant	0.82	0.82	Other	44	67
186	MEL.neurotrophic_migratory	0.88	Nonsignificant	—	0.00	Other	0	0
187	FIB.skin_sheath.ECM_immune	0.86	Nonsignificant	—	0.35	Other	0	0
188	HPC.GMP_inflammatory	0.86	Nonsignificant	0.90	1.05	Other	20	10
189	EPI.salivary_myoepithelial.junctional_transport	0.86	Nonsignificant	3.56e-03	1.78	Other	66	121
190	EPI.esophageal_suprabasal.differentiating_keratin	0.85	Nonsignificant	0.82	0.55	Other	131	61
191	PC.IgA_muocsal.baseline	0.81	Nonsignificant	0.32	1.34	Other	3	5
192	EPI.skin_sweat_duct_keratinocyte.barrier	0.78	Nonsignificant	—	1.36	Other	0	0
193	PERI.cardiac_skeletal	0.77	Nonsignificant	0.26	1.39	Other	313	630
194	FIB.hepatic_stellate_cell.contractile	0.76	Nonsignificant	—	0.32	Other	0	0
195	SCHWN.translation_boost	0.76	Nonsignificant	—	0.08	Other	8	1
196	EPI.endocervical_secretory.squamous_barrier	0.75	Nonsignificant	—	0.00	Other	0	0
197	FIB.hepatic_stellate_cell.fibrogenic	0.74	Nonsignificant	—	0.00	Other	0	0
198	FIB.perivascular_interface.vascular_BM_remodelling	0.73	Nonsignificant	—	0.00	Other	0	0
199	IPSC.neural_primed	0.72	Nonsignificant	0.01	1.24	Other	0	0
200	EPI.pancreatic_acinar.baseline	0.72	Nonsignificant	1.00	0.35	Other	274	163
201	PERI.inflammatory	0.72	Nonsignificant	0.83	1.00	Other	40	77
202	GRNLSA.lipid_hypoxia	0.72	Nonsignificant	0.98	0.93	Other	28	0
203	PERI.angiocrine	0.69	Nonsignificant	0.83	0.90	Other	93	102
204	FIB.skin_sheath.neuro_vascular_interface	0.69	Nonsignificant	—	0.44	Other	0	0
205	ASPC.stem_like_progenitor	0.68	Nonsignificant	1.00	0.06	Other	300	842
206	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.67	Nonsignificant	—	0.96	Other	0	0
207	FIB.skin_neurosecretory.baseline	0.67	Nonsignificant	—	0.00	Other	0	0
208	FIB.transitioning.motility_remodelling	0.65	Nonsignificant	—	0.00	Other	0	0
209	EC.capillary.postcap_venule	0.64	Nonsignificant	0.38	1.19	Other	355	261
210	EPI.thymic_medullary.hormone_xeno_barrier	0.64	Nonsignificant	—	0.00	Other	0	8
211	HPC.CLP_B_primed	0.64	Nonsignificant	—	0.42	Other	0	0
212	FIB.transitioning.secretory_procollagen	0.64	Nonsignificant	—	0.11	Other	0	0
213	PC.IgG_systemic.secretory	0.63	Nonsignificant	0.05	1.54	Other	0	0
214	EC.capillary.migratory	0.62	Nonsignificant	0.72	1.06	Other	181	509
215	EPI.colonic_enteroendocrine.progenitor	0.62	Nonsignificant	—	0.00	Other	0	0
216	EPI.renal_distal_tubule.ciliated_remodelling	0.61	Nonsignificant	—	0.00	Other	0	0
217	FIB.hepatic_stellate_cell.inflammatory	0.61	Nonsignificant	—	0.00	Other	0	0
218	FIB.perivascular_interface.vasomotor_tone	0.61	Nonsignificant	—	0.00	Other	0	0
219	IPSC.endoderm_primed	0.60	Nonsignificant	0.56	1.11	Other	0	0
220	FIB.interstitial.lipid_matrix	0.59	Nonsignificant	1.00	0.00	Other	258	191
221	PC.IgA_muocsal.activated	0.59	Nonsignificant	0.40	1.18	Other	17	8
222	EC.venous.adipose_lipid	0.59	Nonsignificant	2.99e-03	1.51	Other	254	476
223	ADIPO.thermogenic	0.58	Nonsignificant	—	1.09	Other	0	0
224	EPI.lung_club_secretory.ciliogenesis_primed	0.57	Nonsignificant	—	0.00	Other	0	0
225	EPI.alveolar_type_1.activated	0.56	Nonsignificant	—	0.00	Other	0	0
226	EPI.renal_proximal_tubule.detox_antioxidant	0.55	Nonsignificant	0.37	1.49	Other	394	77
227	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.55	Nonsignificant	0.83	1.10	Other	2	9
228	PC.IgA_muocsal.plasmablast	0.54	Nonsignificant	0.99	0.62	Other	5	4
229	IPSC.canonical_pluripotent	0.53	Nonsignificant	0.10	1.14	Other	0	0
230	FIB.skin_sheath.stress_chaperone	0.53	Nonsignificant	—	0.00	Other	0	0
231	FIB.adventitial.PI16_matrix	0.52	Nonsignificant	1.00	0.11	Other	70	90
232	PERI.baseline	0.52	Nonsignificant	0.91	0.60	Other	39	66
233	EC.capillary.angiogenic_tip	0.52	Nonsignificant	0.02	1.55	Other	186	218
234	IPSC.mesenchymal_primed	0.52	Nonsignificant	0.03	1.16	Other	0	0
235	PC.IgA_muocsal.migratory	0.52	Nonsignificant	0.99	0.50	Other	4	1
236	GRNLSA.chemokine_mechanosensory	0.49	Nonsignificant	0.98	0.75	Other	1	0
237	EPI.esophageal_basal.junctional_barrier	0.49	Nonsignificant	—	0.85	Other	0	0
238	EPI.skin_keratinocyte_basal.spinous_transition	0.49	Nonsignificant	—	0.97	Other	0	0
239	EC.capillary.angiocrine	0.49	Nonsignificant	0.75	1.01	Other	250	630
240	EPI.renal_thick_ascending_limb.remodeling	0.48	Nonsignificant	1.00	0.63	Other	152	92
241	GRNLSA.cholesterol_mevalonate	0.47	Nonsignificant	0.98	0.55	Other	9	4
242	EPI.pancreatic_acinar.stress	0.47	Nonsignificant	1.00	0.60	Other	28	28
243	EC.capillary.baseline	0.46	Nonsignificant	0.72	1.03	Other	246	560
244	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.44	Nonsignificant	0.94	0.25	Other	58	89
245	T.CD8_naive.lipid_synthesis	0.44	Nonsignificant	0.31	1.31	Other	6	4
246	EC.capillary.stress	0.43	Nonsignificant	0.94	0.93	Other	44	36
247	EPI.skin_keratinocyte_proliferating.detox_repair	0.42	Nonsignificant	—	1.13	Other	0	0
248	GRNLSA.secretory_remodeling	0.39	Nonsignificant	0.98	0.35	Other	90	25
249	IPSC.stress	0.37	Nonsignificant	0.13	1.21	Other	0	0
250	EPI.skin_keratinocyte_basal.transit_amplifying	0.37	Nonsignificant	—	0.00	Other	0	0
251	CHOND.articular_collagen	0.37	Nonsignificant	0.07	1.28	Other	551	266
252	SMC.metabolic	0.37	Nonsignificant	9.16e-03	1.38	Other	14	40
253	GRNLSA.angiocrine_mechanosensory	0.36	Nonsignificant	—	0.00	Other	0	0
254	EPI.salivary_myoepithelial.contractile_repair	0.36	Nonsignificant	—	0.00	Other	3	9
255	GRNLSA.proliferative_migratory	0.34	Nonsignificant	0.98	1.10	Other	248	292
256	T.CD4_Trm.metal_stress	0.33	Nonsignificant	0.06	1.39	Other	34	58
257	EPI.esophageal_basal.activated_progenitor	0.33	Nonsignificant	1.00	0.00	Other	1	0
258	PC.IgG_systemic.interacting	0.33	Nonsignificant	0.21	1.37	Other	0	0
259	EPI.skin_sebaceous_duct_luminal.detox_repair	0.32	Nonsignificant	0.98	0.14	Other	137	94
260	MG.expanding	0.31	Nonsignificant	0.34	1.25	Other	2	1
261	B.germinal_center.LZ_selection	0.31	Nonsignificant	—	0.34	Other	0	0
262	MUSC.baseline	0.31	Nonsignificant	0.76	1.03	Other	0	0
263	EPI.tracheal_submucosal_gland.acinar_serous	0.30	Nonsignificant	—	0.00	Other	0	0
264	EPI.renal_thick_ascending_limb.cation_flux	0.30	Nonsignificant	1.00	0.30	Other	57	95
265	IPSC.midbrain_primed	0.28	Nonsignificant	1.00	0.88	Other	0	0
266	B.naive.baseline	0.28	Nonsignificant	0.67	1.23	Other	10	13
267	HPC.MPP_IEG	0.28	Nonsignificant	1.00	0.65	Other	45	46
268	SMC.activated	0.28	Nonsignificant	0.83	0.97	Other	2	5
269	B.germinal_center.LZ_survival	0.27	Nonsignificant	—	0.37	Other	0	0
270	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.27	Nonsignificant	1.00	0.18	Other	322	317
271	B.germinal_center.LZ_memory_precursor	0.26	Nonsignificant	—	0.00	Other	0	0
272	EPI.skin_sebaceous_duct_luminal.immune_interface	0.26	Nonsignificant	—	0.00	Other	0	0
273	EPI.skin_follicular_keratinizing.transit_amplifying	0.25	Nonsignificant	—	0.42	Other	21	49
274	B.germinal_center.DZ_S_phase	0.25	Nonsignificant	—	0.21	Other	0	0
275	EPI.salivary_myoepithelial.activated	0.25	Nonsignificant	0.97	0.71	Other	85	281
276	EPI.skin_follicular_keratinizing.root_infundibulum	0.25	Nonsignificant	—	0.58	Other	0	0
277	B.naive.receptor_recycle	0.24	Nonsignificant	0.58	1.32	Other	51	0
278	EC.capillary.activated	0.24	Nonsignificant	0.97	0.67	Other	2	5
279	MG.phagocytic_APC	0.23	Nonsignificant	0.29	1.38	Other	25	8
280	EPI.ectocervical_granular.immune_interact	0.23	Nonsignificant	—	0.32	Other	0	0
281	EPI.skin_sweat_duct_keratinocyte.repair	0.23	Nonsignificant	—	0.76	Other	0	0
282	EPI.salivary_mucous_acinar.baseline	0.22	Nonsignificant	—	—	Other	394	683
283	EC.capillary.inflammatory	0.22	Nonsignificant	0.97	0.77	Other	27	51
284	MUSC.quiescent_reservoir	0.22	Nonsignificant	0.76	1.11	Other	2	8
285	CHOND.remodeling	0.22	Nonsignificant	—	0.50	Other	5	0
286	IPSC.proliferative	0.22	Nonsignificant	1.00	0.93	Other	0	0
287	ADIPO.hypoxia_remodelling	0.21	Nonsignificant	—	0.00	Other	29	105
288	FIB.lung_alveolar.stress_interacting	0.21	Nonsignificant	—	0.97	Other	0	0
289	MUSC.early_activation	0.20	Nonsignificant	0.76	1.00	Other	4	32
290	GRANU.MAST.resting_granule	0.20	Nonsignificant	—	0.73	Other	0	0
291	T.CD4_Tfh.precursor_migratory	0.19	Nonsignificant	0.42	1.17	Other	72	27
292	EC.arterial.metabolic	0.18	Nonsignificant	0.78	1.08	Other	195	159
293	PC.IgG_systemic.metabolic	0.18	Nonsignificant	0.97	0.36	Other	46	63
294	FIB.transitioning.ISG_primed_interface	0.18	Nonsignificant	—	0.00	Other	17	80
295	IPSC.axial_identity_primed	0.18	Nonsignificant	1.00	0.86	Other	0	0
296	EC.venous.quiescent_homeostatic	0.17	Nonsignificant	0.96	1.02	Other	456	360
297	HPC.MPP_activated	0.17	Nonsignificant	—	0.00	Other	0	0
298	EPI.salivary_myoepithelial.baseline	0.16	Nonsignificant	0.97	0.29	Other	42	141
299	B.germinal_center.DZ_M_phase	0.16	Nonsignificant	—	0.00	Other	0	0
300	FIB.lung_alveolar.mito_secretory	0.15	Nonsignificant	—	0.00	Other	0	0
301	B.naive.metabolic	0.15	Nonsignificant	0.67	1.03	Other	50	79
302	PC.IgG_systemic.stress	0.15	Nonsignificant	—	0.00	Other	1	5
303	B.naive.purinergic	0.14	Nonsignificant	0.67	1.08	Other	384	820
304	T.CD4_Th2.tissue_adapted	0.14	Nonsignificant	—	0.97	Other	0	0
305	MAC.resident_iron.stress_tolerogenic	0.14	Nonsignificant	—	1.07	Other	0	0
306	B.naive.remodeling	0.14	Nonsignificant	0.67	1.03	Other	135	230
307	EC.arterial.elastic	0.14	Nonsignificant	0.78	1.00	Other	22	45
308	T.CD4_Tfh.canonical_GC_helper	0.13	Nonsignificant	0.42	1.13	Other	1	2
309	EC.venous.baseline	0.13	Nonsignificant	0.96	1.03	Other	346	807
310	THYMO.proliferative_S	0.13	Nonsignificant	0.01	1.70	Other	163	418
311	MAC.microglia_like.phagocytic_redox	0.13	Nonsignificant	—	0.00	Other	0	0
312	GRANU.MAST.activated_repair	0.12	Nonsignificant	—	0.09	Other	0	1
313	EC.arterial.inflammatory	0.12	Nonsignificant	0.78	0.97	Other	63	50
314	THYMO.SP_CD8_naive_stress	0.12	Nonsignificant	0.18	1.53	Other	1	1
315	B.naive.antigen_presenting_ready	0.12	Nonsignificant	0.92	0.77	Other	48	73
316	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.11	Nonsignificant	—	0.00	Other	0	0
317	B.naive.proteostasis	0.11	Nonsignificant	0.67	1.09	Other	49	69
318	EPI.lung_club_secretory.inflammatory	0.11	Nonsignificant	—	0.00	Other	0	0
319	THYMO.proliferative_G2M	0.11	Nonsignificant	—	0.86	Other	164	413
320	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.11	Nonsignificant	0.21	1.51	Other	33	34
321	ADIPO.inflammatory	0.11	Nonsignificant	—	0.00	Other	0	0
322	MG.baseline	0.11	Nonsignificant	0.99	0.43	Other	16	5
323	T.CD4_Trm.cytotoxic_effector	0.10	Nonsignificant	0.34	1.21	Other	118	77
324	T.CD4_naive.activated_stress	0.10	Nonsignificant	0.57	1.29	Other	339	429
325	EC.arterial.homeostatic	0.10	Nonsignificant	0.78	1.02	Other	24	3
326	FIB.adventitial.activated_remodelling	0.10	Nonsignificant	—	0.00	Other	141	319
327	EPI.skin_keratinocyte_basal.basement_anchoring	0.10	Nonsignificant	—	0.00	Other	0	0
328	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.10	Nonsignificant	—	0.18	Other	0	0
329	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.09	Nonsignificant	—	0.22	Other	39	82
330	ADIPO.immature	0.09	Nonsignificant	—	0.00	Other	24	40
331	CHOND.activated_fibro_like	0.09	Nonsignificant	1.00	0.65	Other	531	188
332	EPI.skin_follicular_keratinizing.upper_infundibulum	0.09	Nonsignificant	—	0.00	Other	8	2
333	B.naive.activated	0.08	Nonsignificant	0.92	0.74	Other	77	127
334	SMC.contractile	0.08	Nonsignificant	1.00	0.69	Other	80	588
335	ILC2.activated	0.08	Nonsignificant	—	0.23	Other	0	0
336	MAC.resident_iron.redox_metabolic	0.08	Nonsignificant	0.84	1.01	Other	4	4
337	MAC.resident_iron.APC_iron_sensing	0.07	Nonsignificant	0.23	1.19	Other	211	114
338	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.07	Nonsignificant	0.75	0.68	Other	7	16
339	B.naive.restrained	0.07	Nonsignificant	0.92	0.88	Other	183	353
340	EC.arterial.arteriole_gas_exchange	0.07	Nonsignificant	0.89	0.94	Other	238	131
341	ILC2.quiescent	0.07	Nonsignificant	—	0.00	Other	0	0
342	THYMO.SP_CD4_naive	0.07	Nonsignificant	0.46	1.20	Other	65	75
343	NEU.INH_VIP.matrix	0.07	Nonsignificant	—	1.31	Other	24	77
344	THYMO.CD8aa_IELp	0.07	Nonsignificant	—	0.25	Other	1	7
345	EC.arterial.mito_contact	0.06	Nonsignificant	0.78	1.05	Other	14	5
346	MAC.microglia_like.inflammatory_chemokine	0.06	Nonsignificant	—	0.00	Other	20	32
347	EPI.pancreatic_islet.beta	0.06	Nonsignificant	1.00	0.14	Other	42	57
348	T.CD4_Tfh.effector_migratory	0.06	Nonsignificant	0.42	1.25	Other	122	57
349	THYMO.DN_preTCR	0.06	Nonsignificant	0.18	1.38	Other	41	71
350	EPI.skin_appendage_keratinocyte.transit_amplifying	0.05	Nonsignificant	—	0.00	Other	109	358
351	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.05	Nonsignificant	—	0.46	Other	0	0
352	IPSC.stromal_primed	0.05	Nonsignificant	1.00	0.58	Other	0	0
353	HEP.periportal_metabolic.stress_chaperone	0.05	Nonsignificant	—	1.08	Other	66	128
354	THYMO.SP_CD8_naive	0.04	Nonsignificant	0.98	0.61	Other	297	177
355	THYMO.DP_early	0.04	Nonsignificant	0.98	0.69	Other	326	313
356	HEP.pericentral_lipoprotein.UPR_redox	0.04	Nonsignificant	—	0.67	Other	0	0
357	ILC2.migratory	0.04	Nonsignificant	—	0.00	Other	0	0
358	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.04	Nonsignificant	—	0.00	Other	0	0
359	B.memory.activated	0.04	Nonsignificant	0.46	1.20	Other	105	29
360	HEP.pericentral_lipoprotein.ApoB_coagulation	0.04	Nonsignificant	—	0.00	Other	0	0
361	EC.arterial.ion_pump	0.04	Nonsignificant	0.53	1.26	Other	3	2
362	MUSC.activated_migratory	0.04	Nonsignificant	0.96	0.37	Other	6	7
363	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	0.04	Nonsignificant	—	0.00	Other	0	0
364	THYMO.DP_early_stress	0.04	Nonsignificant	—	0.00	Other	0	0
365	EC.venous.activated	0.04	Nonsignificant	1.00	0.54	Other	247	752
366	NEU.INH_VIP.LAMP5_hybrid	0.04	Nonsignificant	—	1.44	Other	1	9
367	T.CD8_transitional.stress	0.03	Nonsignificant	—	1.98	Other	24	34
368	GRANU.MAST.activated_acute	0.03	Nonsignificant	—	0.00	Other	0	0
369	T.CD4_Th2.precursor	0.03	Nonsignificant	—	0.00	Other	0	0
370	EC.lymphatic.valve	0.03	Nonsignificant	—	1.70	Other	0	0
371	EPI.pancreatic_islet.delta	0.03	Nonsignificant	—	0.00	Other	0	0
372	ASTRO.immature_lipid	0.03	Nonsignificant	0.49	1.23	Other	23	113
373	ASTRO.hypoxia_angiogenic	0.03	Nonsignificant	0.49	1.30	Other	5	18
374	MAC.proliferating.DNA_replication	0.03	Nonsignificant	0.05	1.50	Other	3	6
375	EC.venous.cardiac_structural	0.03	Nonsignificant	1.00	0.72	Other	102	229
376	T.CD4_Tfh.suppression_exhaustion	0.02	Nonsignificant	0.93	0.63	Other	0	2
377	THYMO.SP_CD8_transitional	0.02	Nonsignificant	0.98	0.54	Other	32	75
378	PLAT.megakaryocytic	0.02	Nonsignificant	—	0.97	Other	0	0
379	HPC.MEP	0.02	Nonsignificant	1.00	0.11	Other	599	1,195
380	MONO.CD14.platelet_bound	0.02	Nonsignificant	0.21	1.13	Other	964	176
381	DC.cDC2.tolerogenic_regulatory	0.02	Nonsignificant	1.00	1.10	Other	44	4
382	EC.arterial.arteriole_interface	0.02	Nonsignificant	1.00	0.70	Other	31	12
383	B.memory.baseline	0.02	Nonsignificant	0.93	0.92	Other	472	99
384	DC.cDC2.lipid_metabolic	0.02	Nonsignificant	—	1.52	Other	0	0
385	T.CD4_Trm.activated	0.02	Nonsignificant	0.72	1.12	Other	32	26
386	B.memory.preactivated	0.02	Nonsignificant	0.93	0.96	Other	173	174
387	T.CD8_Trm.homeostatic	0.02	Nonsignificant	0.65	1.07	Other	42	5
388	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.59	1.07	Other	28	6
389	T.CD8_Tcm.effector_bias	0.02	Nonsignificant	0.43	1.24	Other	199	329
390	T.CD4_Tem.transitional_CM	0.02	Nonsignificant	0.61	1.05	Other	31	20
391	MAC.kupffer.stress	0.02	Nonsignificant	0.08	1.26	Other	9	3
392	SCHWN.axon_contact_cardiac	0.02	Nonsignificant	0.99	0.25	Other	18	63
393	ASTRO.stress_acute	0.02	Nonsignificant	0.80	1.09	Other	60	56
394	B.memory.migratory	0.02	Nonsignificant	0.93	0.91	Other	123	208
395	CHOND.pro_inflammatory	0.01	Nonsignificant	1.00	0.17	Other	181	351
396	ASTRO.A2_reactive	0.01	Nonsignificant	0.80	1.14	Other	10	37
397	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	0.59	1.06	Other	314	587
398	MAC.resident_iron.heme_catabolism	0.01	Nonsignificant	0.87	0.74	Other	30	51
399	EC.venous.remodeling_stalk	0.01	Nonsignificant	1.00	0.33	Other	559	566
400	EC.heart_remodeling.translation_boost	0.01	Nonsignificant	—	1.80	Other	0	0
401	MAC.MDM.APC_dendritic	0.01	Nonsignificant	0.47	1.14	Other	48	15
402	T.CD4_transitional.primed_helper_effector	0.01	Nonsignificant	0.74	1.13	Other	19	43
403	DC.cDC2.proliferative	0.01	Nonsignificant	—	1.12	Other	39	71
404	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.01	Nonsignificant	—	0.00	Other	43	26
405	NEU.INH_VIP.enkephalinergic	0.01	Nonsignificant	—	1.08	Other	0	0
406	T.CD8_Trm.inflammatory	0.01	Nonsignificant	0.65	1.06	Other	124	176
407	T.CD4_transitional.baseline	0.01	Nonsignificant	0.77	1.06	Other	59	97
408	T.CD4_Tcm.effector_like	0.01	Nonsignificant	0.75	1.13	Other	293	533
409	EPI.ectocervical_granular.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
410	T.CD4_Trm.baseline	0.01	Nonsignificant	0.90	0.95	Other	31	21
411	MAC.LAM.lipid_opsonization	0.01	Nonsignificant	0.57	1.19	Other	45	14
412	T.CD4_Trm.central_like	0.01	Nonsignificant	0.90	0.91	Other	38	31
413	T.CD8_Trm.cytotoxic	0.01	Nonsignificant	0.65	1.05	Other	165	85
414	DC.cDC1.baseline	0.01	Nonsignificant	—	1.53	Other	0	0
415	MAC.LAM.lipid_phagocytosis	0.01	Nonsignificant	0.57	1.13	Other	369	328
416	B.memory.pDC_imprint	0.01	Nonsignificant	0.93	0.62	Other	157	103
417	HEP.canalicular_transport.ductular_like_transition	9.72e-03	Nonsignificant	0.67	1.11	Other	400	87
418	T.CD4_transitional.primed_cytotoxic	9.52e-03	Nonsignificant	0.98	0.90	Other	28	30
419	EPI.skin_sweat_duct_keratinocyte.proliferative_S	9.42e-03	Nonsignificant	—	0.00	Other	0	0
420	IPSC.mesendo_primed	8.74e-03	Nonsignificant	1.00	0.38	Other	0	0
421	T.CD4_naive.gut_prone	8.36e-03	Nonsignificant	0.86	1.14	Other	35	70
422	T.CD4_Treg.central_naive_like	8.24e-03	Nonsignificant	0.56	1.11	Other	333	45
423	ASTRO.synaptic_interaction	7.47e-03	Nonsignificant	0.95	0.98	Other	76	334
424	EC.liver_sinusoidal.prostanoid	7.45e-03	Nonsignificant	—	0.22	Other	11	64
425	T.CD4_Tcm.tissue_homing	6.31e-03	Nonsignificant	0.75	1.10	Other	78	46
426	EC.lymphatic.activated	6.25e-03	Nonsignificant	0.99	1.03	Other	47	73
427	MAC.proliferating.stress	6.08e-03	Nonsignificant	—	0.00	Other	87	136
428	EC.heart_remodeling.remodeling_stalk	5.83e-03	Nonsignificant	0.77	1.20	Other	33	111
429	T.CD8_Trm.dendritic_recruiter	5.59e-03	Nonsignificant	0.68	0.88	Other	47	85
430	T.CD8_naive.mito_proteostasis	5.57e-03	Nonsignificant	0.40	1.15	Other	428	100
431	T.CD4_naive.proteostasis	5.19e-03	Nonsignificant	0.86	1.07	Other	14	9
432	NEU.INH_VIP.develop_niche	4.95e-03	Nonsignificant	—	0.63	Other	0	0
433	MAC.kupffer.tolerogenic	4.88e-03	Nonsignificant	—	0.72	Other	45	49
434	MONO.CD16.platelet_bound	4.76e-03	Nonsignificant	0.13	1.26	Other	372	508
435	MAC.resident_cardiac.antigen_presenting	4.72e-03	Nonsignificant	0.31	1.16	Other	52	27
436	T.CD4_naive.mature	4.67e-03	Nonsignificant	0.57	1.05	Other	211	100
437	T.CD4_Tcm.DC_interact	4.63e-03	Nonsignificant	0.75	1.10	Other	72	32
438	T.CD8_Trm.muscosal_Tc17	4.55e-03	Nonsignificant	0.65	0.98	Other	19	38
439	NK.cytokine_lung_immediate_early	4.36e-03	Nonsignificant	0.38	1.26	Other	424	274
440	CHOND.angiogenic	4.27e-03	Nonsignificant	—	0.00	Other	0	0
441	MAC.LAM.inflammatory_APC	4.24e-03	Nonsignificant	0.86	1.00	Other	872	165
442	CM.contractile_oxphos	4.19e-03	Nonsignificant	0.48	1.10	Other	6	19
443	T.CD8_naive.nfkb_related	4.10e-03	Nonsignificant	0.40	1.15	Other	1	0
444	HEP.periportal_metabolic.apolipoprotein_secretory	4.01e-03	Nonsignificant	0.80	1.22	Other	43	110
445	MAC.MDM.inflammatory_phagocytic	4.01e-03	Nonsignificant	0.81	0.97	Other	199	52
446	T.CD4_naive.survival	3.96e-03	Nonsignificant	0.86	1.07	Other	12	17
447	T.CD4_naive.homeostatic	3.94e-03	Nonsignificant	0.57	1.07	Other	215	108
448	T.CD4_Trm.stress_adaptive	3.79e-03	Nonsignificant	1.00	0.66	Other	8	22
449	T.CD8_transitional.effector_primed	3.35e-03	Nonsignificant	0.20	1.08	Other	435	151
450	T.CD8_naive.effector_transition	3.34e-03	Nonsignificant	0.40	1.13	Other	35	62
451	EC.arterial.angiogenic_tip	3.32e-03	Nonsignificant	—	0.00	Other	30	37
452	T.CD8_naive.vesicle_secretory	3.18e-03	Nonsignificant	0.40	1.14	Other	42	0
453	B.age_associated.migratory	3.10e-03	Nonsignificant	0.40	1.23	Other	2	2
454	T.CD8_naive.baseline	3.09e-03	Nonsignificant	0.87	0.95	Other	142	2
455	MAC.LAM.perivascular_angiocrine	3.06e-03	Nonsignificant	—	0.70	Other	53	138
456	EPI.ectocervical_granular.secretory_apocrine	3.03e-03	Nonsignificant	—	0.00	Other	0	0
457	DC.cDC2.antiviral	3.02e-03	Nonsignificant	1.00	0.90	Other	100	37
458	T.CD4_Treg.tissue_effector	2.98e-03	Nonsignificant	0.62	1.11	Other	16	13
459	DC.mig.baseline	2.94e-03	Nonsignificant	—	0.00	Other	1	0
460	NEU.INH_PVALB.chandelier	2.93e-03	Nonsignificant	0.85	1.09	Other	19	16
461	MAC.kupffer.monocyte_like	2.90e-03	Nonsignificant	—	0.51	Other	0	0
462	T.CD4_transitional.APC_interacting	2.89e-03	Nonsignificant	0.98	0.87	Other	10	14
463	T.CD4_Th17.migratory	2.86e-03	Nonsignificant	0.74	1.05	Other	13	23
464	T.CD8_Tem.baseline	2.75e-03	Nonsignificant	0.29	1.09	Other	458	356
465	NEU.EXC_IT.structural	2.74e-03	Nonsignificant	0.45	1.18	Other	171	41
466	EC.heart_remodeling.angiocrine	2.65e-03	Nonsignificant	0.77	1.01	Other	182	525
467	ASTRO.A1_reactive	2.65e-03	Nonsignificant	0.84	1.04	Other	433	394
468	T.MAIT.stress	2.64e-03	Nonsignificant	—	0.39	Other	0	0
469	EPI.skin_interfollicular_spinous.stress_oxidative	2.61e-03	Nonsignificant	—	1.28	Other	0	0
470	T.CD4_Tcm.migratory_cilium	2.51e-03	Nonsignificant	0.75	1.11	Other	5	10
471	T.CD8_transitional.early	2.40e-03	Nonsignificant	0.20	1.07	Other	327	55
472	T.CD4_Tcm.APC_mimicry	2.32e-03	Nonsignificant	0.75	1.08	Other	54	43
473	T.CD4_naive.Treg_like	2.32e-03	Nonsignificant	0.86	1.13	Other	121	72
474	MAC.LAM.anti_inflammatory	2.28e-03	Nonsignificant	0.97	0.88	Other	86	132
475	T.CD4_Th17.cytotoxic	2.28e-03	Nonsignificant	0.74	1.02	Other	332	123
476	T.CD4_naive.resist_bystander	2.26e-03	Nonsignificant	0.97	1.00	Other	40	25
477	CM.baseline	2.26e-03	Nonsignificant	0.48	1.03	Other	393	0
478	MAC.MDM.LAM_like	2.25e-03	Nonsignificant	0.66	1.10	Other	12	14
479	T.CD4_Treg.APC_interactive	2.25e-03	Nonsignificant	0.62	1.00	Other	118	28
480	T.CD4_Tcm.Tfh_like	2.17e-03	Nonsignificant	0.75	1.03	Other	102	214
481	T.CD4_Tcm.crosstalk_myeloid	2.08e-03	Nonsignificant	0.75	1.09	Other	5	4
482	T.MAIT.early_activation	2.05e-03	Nonsignificant	0.53	1.19	Other	57	4
483	NEU.INH_PVALB.fastspike	2.02e-03	Nonsignificant	—	0.00	Other	24	22
484	MONO.CD16.baseline	2.00e-03	Nonsignificant	0.13	1.15	Other	50	1
485	T.CD4_Tcm.imprinted_splicing	1.98e-03	Nonsignificant	0.75	1.07	Other	6	17
486	NEU.INH_VIP.excitatory_coupled	1.97e-03	Nonsignificant	—	0.02	Other	13	0
487	NEU.INH_VIP.cannabinoid	1.93e-03	Nonsignificant	—	0.17	Other	0	0
488	T.CD4_Tcm.Th2_like	1.93e-03	Nonsignificant	0.75	1.12	Other	23	55
489	NEU.INH_PVALB.metabotropic	1.93e-03	Nonsignificant	—	0.81	Other	0	0
490	EC.lymphatic.tip_migratory	1.90e-03	Nonsignificant	0.99	1.05	Other	23	37
491	T.CD4_Th17.baseline	1.76e-03	Nonsignificant	0.88	0.90	Other	51	5
492	EC.heart_remodeling.remodeling_secretory	1.69e-03	Nonsignificant	0.77	0.94	Other	605	1,341
493	DC.cDC2.pro_inflammatory	1.67e-03	Nonsignificant	1.00	1.01	Other	3	5
494	MAC.resident_cardiac.inflammatory_reparative	1.62e-03	Nonsignificant	0.31	1.21	Other	31	96
495	B.age_associated.naive_transitional	1.60e-03	Nonsignificant	—	0.30	Other	0	0
496	NK.immature_bridge	1.55e-03	Nonsignificant	0.68	1.10	Other	117	122
497	EC.liver_sinusoidal.secretory_lipoprotein	1.48e-03	Nonsignificant	0.49	1.17	Other	120	70
498	T.MAIT.MAPK_brake	1.43e-03	Nonsignificant	0.53	1.18	Other	44	66
499	ASTRO.homeostatic	1.42e-03	Nonsignificant	0.99	0.69	Other	200	431
500	T.CD4_naive.mature_mitoprot	1.42e-03	Nonsignificant	1.00	0.86	Other	212	476
501	MAC.resident_iron.heme_recycling	1.36e-03	Nonsignificant	—	0.00	Other	30	37
502	T.CD4_naive.neddylation	1.34e-03	Nonsignificant	0.97	0.88	Other	104	222
503	GRANU.neutrophil.primed_degranulation	1.33e-03	Nonsignificant	—	0.90	Other	0	0
504	T.CD8_transitional.APC_like	1.23e-03	Nonsignificant	0.90	0.90	Other	205	62
505	HEP.periportal_metabolic.urea_onecarbon_secretory	1.16e-03	Nonsignificant	0.80	1.01	Other	1,332	3,053
506	T.CD4_Trm.helper_like	1.15e-03	Nonsignificant	1.00	0.37	Other	84	147
507	MONO.CD16.patrolling	1.10e-03	Nonsignificant	0.55	1.04	Other	797	216
508	HEP.periportal_metabolic.stress_checkpoint	1.04e-03	Nonsignificant	0.80	1.10	Other	234	786
509	OLG.stress	1.02e-03	Nonsignificant	0.86	1.14	Other	232	8
510	T.CD4_naive.neddylation_mitoprot	1.02e-03	Nonsignificant	0.97	0.89	Other	93	56
511	EC.liver_sinusoidal.stress	1.01e-03	Nonsignificant	—	0.07	Other	413	158
512	T.MAIT.migratory	9.88e-04	Nonsignificant	0.90	1.05	Other	10	1
513	T.CD4_naive.survival_neddylation	9.59e-04	Nonsignificant	0.97	0.82	Other	26	38
514	T.CD4_Tcm.stress	9.55e-04	Nonsignificant	0.84	1.04	Other	5	11
515	T.CD4_naive.proteostasis_mitoprot	8.88e-04	Nonsignificant	0.97	0.88	Other	15	37
516	T.CD8_naive.cytokine_dampened	8.66e-04	Nonsignificant	0.94	0.84	Other	71	4
517	MAC.MDM.complement_resolving	8.41e-04	Nonsignificant	0.81	0.90	Other	440	860
518	EC.heart_remodeling.activated_acute	8.34e-04	Nonsignificant	0.77	1.04	Other	102	186
519	T.CD4_Tcm.baseline	8.33e-04	Nonsignificant	0.87	0.99	Other	61	31
520	MONO.CD14.APC_like	8.32e-04	Nonsignificant	0.21	1.09	Other	1,686	2,493
521	NK.adaptive_immature_precursor	7.93e-04	Nonsignificant	0.38	1.21	Other	358	111
522	T.CD4_naive.purinergic	7.76e-04	Nonsignificant	0.97	0.96	Other	49	1
523	EC.heart_remodeling.capillary_metabolic	7.70e-04	Nonsignificant	0.77	0.95	Other	54	414
524	T.CD8_naive.splicing_enriched	7.62e-04	Nonsignificant	0.94	0.80	Other	120	16
525	T.CD8_transitional.Trm_primed	7.62e-04	Nonsignificant	0.90	0.89	Other	108	15
526	EC.lymphatic.baseline	7.60e-04	Nonsignificant	1.00	0.80	Other	38	72
527	OPC.homeostatic	7.24e-04	Nonsignificant	0.55	1.17	Other	394	160
528	T.CD4_Tcm.regulatory_poised	7.15e-04	Nonsignificant	0.87	0.93	Other	2	3
529	MAC.resident_repair.chemokine_angiocrine	6.51e-04	Nonsignificant	0.88	1.08	Other	87	138
530	MAC.LAM.antimicrobial	6.25e-04	Nonsignificant	0.97	0.74	Other	389	93
531	NEU.INH_VIP.nuclear_reg	6.08e-04	Nonsignificant	—	0.08	Other	20	4
532	T.CD4_cytotoxic.precursor	5.93e-04	Nonsignificant	0.76	1.33	Other	156	67
533	GRANU.neutrophil.antiviral_endotoxin	5.08e-04	Nonsignificant	—	0.00	Other	0	0
534	NK.cytokine_axis_baseline	5.08e-04	Nonsignificant	0.68	1.02	Other	1,172	116
535	EC.liver_sinusoidal.hypoxia_metabolic	5.05e-04	Nonsignificant	0.49	1.01	Other	183	107
536	NK.adaptive_classII_inhibitory	4.94e-04	Nonsignificant	0.68	1.10	Other	880	154
537	DC.cDC1.cross_presenting	4.68e-04	Nonsignificant	—	0.36	Other	0	0
538	EPI.skin_interfollicular_spinous.transition_basal	4.67e-04	Nonsignificant	0.67	1.15	Other	100	127
539	NK.cytokine_quiescent	4.58e-04	Nonsignificant	0.68	1.10	Other	623	1,062
540	ASTRO.stress_mito	4.57e-04	Nonsignificant	0.99	0.67	Other	47	110
541	T.gamma_delta.cytotoxic_effector	4.46e-04	Nonsignificant	0.59	1.04	Other	349	109
542	NK.cytokine_tissue_resident	4.36e-04	Nonsignificant	0.68	1.09	Other	74	82
543	T.CD8_Tcm.baseline	4.36e-04	Nonsignificant	0.97	1.06	Other	90	89
544	MONO.CD14.baseline	4.20e-04	Nonsignificant	0.98	0.97	Other	2,268	76
545	NEU.INH_VIP.opioid	4.17e-04	Nonsignificant	—	0.00	Other	50	9
546	MAC.resident_repair.antigen_presenting	4.11e-04	Nonsignificant	0.88	1.00	Other	244	113
547	T.CD8_Tcm.helper_like	4.04e-04	Nonsignificant	1.00	0.88	Other	81	159
548	MONO.CD14.remodeling	4.01e-04	Nonsignificant	0.98	1.00	Other	2,373	295
549	DC.cDC2.adhesion_signaling	3.86e-04	Nonsignificant	1.00	0.70	Other	35	9
550	DC.cDC1.activated	3.83e-04	Nonsignificant	—	0.32	Other	0	0
551	T.CD8_Tem.signaling_turnover	3.82e-04	Nonsignificant	0.77	1.10	Other	425	683
552	EC.heart_remodeling.perivascular	3.78e-04	Nonsignificant	1.00	0.39	Other	124	408
553	ASTRO.neuromodulatory	3.69e-04	Nonsignificant	0.99	0.65	Other	34	172
554	EPI.skin_keratinocyte_proliferating.early_spinous_transition	3.66e-04	Nonsignificant	—	0.00	Other	135	290
555	T.CD4_naive.survival_mitoprot	3.63e-04	Nonsignificant	0.97	0.77	Other	13	7
556	MAC.resident_repair.ECM_stromal_crosstalk	3.58e-04	Nonsignificant	0.88	0.99	Other	95	158
557	NK.adaptive_axis_baseline	3.49e-04	Nonsignificant	0.68	1.04	Other	1,008	153
558	NK.cytokine_repair_primed	3.45e-04	Nonsignificant	0.68	1.13	Other	266	11
559	T.CD8_Tem.TEMRA	3.39e-04	Nonsignificant	0.77	1.00	Other	920	1,088
560	T.CD8_naive.innate_like	2.95e-04	Nonsignificant	0.94	0.65	Other	10	1
561	NK.cytokine_vascular_patrolling	2.92e-04	Nonsignificant	0.75	0.98	Other	863	94
562	T.gamma_delta.early_effector	2.90e-04	Nonsignificant	0.59	0.99	Other	89	0
563	T.CD4_transitional.tissue_enagement	2.70e-04	Nonsignificant	0.98	0.48	Other	5	11
564	T.gamma_delta.central_memory	2.66e-04	Nonsignificant	0.59	1.02	Other	460	919
565	T.CD4_Tem.cytotoxic_effector	2.66e-04	Nonsignificant	1.00	0.56	Other	225	398
566	T.CD4_Tcm.synapse_dynamics	2.46e-04	Nonsignificant	0.87	0.91	Other	15	10
567	DC.cDC2.migratory	2.41e-04	Nonsignificant	1.00	0.69	Other	185	39
568	T.MAIT.quiescent	2.41e-04	Nonsignificant	0.91	0.77	Other	100	5
569	MONO.CD14.inflammatory	2.21e-04	Nonsignificant	0.83	1.11	Other	92	134
570	HEP.periportal_metabolic.xenobiotic_detox	2.13e-04	Nonsignificant	1.00	0.87	Other	1,440	139
571	B.age_associated.activated	2.13e-04	Nonsignificant	—	0.00	Other	18	22
572	MAC.resident_cardiac.phagocytic_homeostasis	2.10e-04	Nonsignificant	1.00	0.42	Other	564	1,221
573	HEP.canalicular_transport.injury_stress	2.07e-04	Nonsignificant	0.67	1.05	Other	289	24
574	NK.cytokine_biosynthetic_primed	1.98e-04	Nonsignificant	0.75	0.95	Other	360	21
575	T.MAIT.vesicle	1.93e-04	Nonsignificant	0.91	0.79	Other	37	65
576	OLG.myelinating_mature	1.63e-04	Nonsignificant	0.86	1.03	Other	363	94
577	T.CD8_Tcm.NK_like	1.54e-04	Nonsignificant	1.00	0.83	Other	334	581
578	NEU.EXC_SYT2.synaptic	1.47e-04	Nonsignificant	—	0.48	Other	0	0
579	EPI.skin_interfollicular_spinous.inflammatory	1.43e-04	Nonsignificant	—	0.90	Other	0	0
580	T.CD4_Tcm.retro_ZNF117	1.43e-04	Nonsignificant	0.87	0.85	Other	5	9
581	T.CD8_Tem.early_helper_like	1.42e-04	Nonsignificant	0.77	1.00	Other	445	755
582	NK.adaptive_HLAE_tuned	1.41e-04	Nonsignificant	0.68	1.07	Other	1,124	189
583	T.CD4_cytotoxic.terminal_effector	1.36e-04	Nonsignificant	0.76	1.03	Other	286	21
584	IPSC.mesodermal_primed	1.31e-04	Nonsignificant	1.00	0.18	Other	0	0
585	HEP.periportal_metabolic.acute_phase_barrier	1.24e-04	Nonsignificant	0.80	1.05	Other	533	138
586	HEP.canalicular_transport.pericentral_like_hypoxia	1.18e-04	Nonsignificant	0.67	1.05	Other	326	8
587	EPI.skin_interfollicular_spinous.upper_lipid	1.15e-04	Nonsignificant	—	0.46	Other	6	6
588	NK.cytokine_tissue_activation	1.15e-04	Nonsignificant	0.69	1.05	Other	267	450
589	T.MAIT.cytotoxic	1.01e-04	Nonsignificant	0.91	0.68	Other	52	15
590	NK.adaptive_terminal_cytotoxic	9.32e-05	Nonsignificant	0.75	0.99	Other	485	802
591	NEU.INH_VIP.serotonergic	9.29e-05	Nonsignificant	—	0.00	Other	9	2
592	NK.adaptive_biosynthetic_primed	8.21e-05	Nonsignificant	0.89	0.79	Other	244	405
593	T.CD8_Tem.stress_adapted	7.86e-05	Nonsignificant	0.82	0.92	Other	607	520
594	T.CD4_Tcm.RNA_control	7.80e-05	Nonsignificant	0.98	0.75	Other	96	4
595	T.CD4_Tcm.secretory	7.64e-05	Nonsignificant	0.87	0.89	Other	20	11
596	MONO.CD16.hepatic_mac_like	7.61e-05	Nonsignificant	1.00	0.79	Other	803	117
597	SKM.type_1_slow.glycolytic	7.42e-05	Nonsignificant	0.07	1.17	Other	362	647
598	DC.cDC2.monocyte_like	7.09e-05	Nonsignificant	1.00	0.55	Other	1,285	791
599	HEP.acute_phase.stress_secretory	6.98e-05	Nonsignificant	0.05	1.29	Other	26	3
600	CM.sarcomere_actin_interface	6.90e-05	Nonsignificant	1.00	1.00	Other	450	78
601	GRANU.neutrophil.tissue_patrolling	6.60e-05	Nonsignificant	—	0.00	Other	0	0
602	OLG.myelinating_stress	6.30e-05	Nonsignificant	0.86	0.95	Other	232	62
603	NEU.EXC_IT.transitional	6.21e-05	Nonsignificant	0.65	1.16	Other	237	142
604	NK.adaptive_adipose_stress	5.28e-05	Nonsignificant	0.89	0.77	Other	374	39
605	NEU.EXC_IT.neuromodulated	5.21e-05	Nonsignificant	0.65	1.13	Other	176	116
606	OLG.reactive_repair	4.89e-05	Nonsignificant	0.86	0.98	Other	385	385
607	OPC.premyelinating	4.85e-05	Nonsignificant	0.86	0.88	Other	185	12
608	NEU.INH_LAMP5.exc_inh_balance	4.43e-05	Nonsignificant	—	0.07	Other	46	2
609	T.CD4_Treg.Tr1_like	4.10e-05	Nonsignificant	—	1.48e-03	Other	8	8
610	MONO.CD16.inflammatory	4.01e-05	Nonsignificant	1.00	0.63	Other	1,640	168
611	OLG.regulatory	3.90e-05	Nonsignificant	0.86	0.92	Other	353	73
612	ASPC.signal_integrator	3.75e-05	Nonsignificant	—	0.00	Other	0	0
613	MAC.resident_repair.lipid_phagocytic	3.69e-05	Nonsignificant	0.88	0.83	Other	228	604
614	T.CD4_cytotoxic.baseline	3.58e-05	Nonsignificant	0.76	0.95	Other	0	0
615	DC.cDC1.proliferative	3.11e-05	Nonsignificant	—	0.00	Other	0	0
616	NEU.INH_PVALB.nuclear_reg	2.91e-05	Nonsignificant	0.97	0.47	Other	25	12
617	HEP.canalicular_transport.secretory_ERAD_UPR	2.84e-05	Nonsignificant	0.67	1.04	Other	232	28
618	T.CD4_cytotoxic.activated	2.79e-05	Nonsignificant	0.76	1.01	Other	3	1
619	OLG.regulatory_activated	2.24e-05	Nonsignificant	0.86	0.93	Other	196	614
620	NEU.INH_VIP.regulatory_remodeling	2.19e-05	Nonsignificant	—	0.00	Other	6	1
621	NEU.INH_PVALB.serotonergic	1.97e-05	Nonsignificant	—	0.00	Other	0	0
622	EC.lymphatic.scavenger	1.87e-05	Nonsignificant	1.00	0.24	Other	203	257
623	EC.liver_sinusoidal.remodeling_lipotoxicity	1.82e-05	Nonsignificant	—	0.00	Other	90	58
624	HEP.acute_phase.proliferative	1.78e-05	Nonsignificant	—	0.92	Other	4	6
625	HEP.periportal_metabolic.inflammatory_activated	1.68e-05	Nonsignificant	1.00	0.93	Other	712	1,610
626	T.CD8_Tem.motility_primed	1.63e-05	Nonsignificant	0.77	0.95	Other	269	4
627	CM.osmoprotection	1.53e-05	Nonsignificant	1.00	0.98	Other	34	57
628	PLAT.adhesion	1.52e-05	Nonsignificant	—	0.00	Other	0	0
629	OPC.proliferative_immune_interact	1.44e-05	Nonsignificant	0.86	0.78	Other	180	373
630	CM.mechano_activated	1.36e-05	Nonsignificant	1.00	0.98	Other	205	134
631	MAC.resident_repair.stress_iron	1.34e-05	Nonsignificant	0.88	0.64	Other	48	97
632	NEU.INH_LAMP5.projecting	1.33e-05	Nonsignificant	—	0.18	Other	0	0
633	EPI.skin_interfollicular_spinous.early_differentiation	1.24e-05	Nonsignificant	0.97	0.82	Other	89	19
634	NEU.INH_VIP.canonical_disinhibitory	1.23e-05	Nonsignificant	0.96	0.50	Other	59	38
635	EPI.skin_interfollicular_spinous.proliferative	1.17e-05	Nonsignificant	—	0.52	Other	0	0
636	MAC.alveolar.inflammatory	1.14e-05	Nonsignificant	0.71	1.06	Other	208	312
637	NEU.INH_LAMP5.rosehip	1.12e-05	Nonsignificant	—	0.13	Other	0	0
638	NEU.EXC_CT.remodeling	1.12e-05	Nonsignificant	—	0.31	Other	23	1
639	T.CD4_cytotoxic.NK_adapted	1.10e-05	Nonsignificant	0.90	0.67	Other	82	33
640	OLG.vesicle_trafficking	1.03e-05	Nonsignificant	0.95	0.76	Other	124	10
641	NEU.EXC_IT.adhesion	9.92e-06	Nonsignificant	0.67	1.06	Other	252	108
642	CM.oxidative_phospho	9.80e-06	Nonsignificant	1.00	1.00	Other	266	792
643	CM.inflammatory	8.85e-06	Nonsignificant	—	1.24	Other	0	0
644	DC.pDC.baseline	7.47e-06	Nonsignificant	0.80	1.20	Other	88	123
645	HEP.periportal_metabolic.canonical_urea_cycle	7.31e-06	Nonsignificant	1.00	0.49	Other	1,464	269
646	NEU.INH_LAMP5.glial_interface	6.40e-06	Nonsignificant	—	0.00	Other	0	0
647	DC.cDC1.homeostatic_inhibitory	5.61e-06	Nonsignificant	—	0.00	Other	0	0
648	HEP.canalicular_transport.sterol_lipid_biosynthesis	5.25e-06	Nonsignificant	—	0.61	Other	10	20
649	NEU.EXC_CT.projector	4.70e-06	Nonsignificant	0.59	1.04	Other	87	26
650	MAC.kupffer.inflammatory	4.50e-06	Nonsignificant	—	0.00	Other	7	4
651	CM.mito_proteostasis	3.93e-06	Nonsignificant	1.00	0.96	Other	329	29
652	T.CD8_Tcm.gut_homing	3.86e-06	Nonsignificant	1.00	0.18	Other	380	112
653	HEP.acute_phase.complement_antiviral	3.60e-06	Nonsignificant	0.98	1.06	Other	377	751
654	SKM.type_2_fast.glycolytic_IIx_IIb	3.30e-06	Nonsignificant	0.11	1.11	Other	565	1,482
655	HEP.canalicular_transport.inflammatory	3.29e-06	Nonsignificant	1.00	0.78	Other	1,335	194
656	MAC.kupffer.metabolic	3.18e-06	Nonsignificant	—	0.00	Other	25	36
657	MAC.alveolar.capillary_interacting	3.18e-06	Nonsignificant	0.71	1.20	Other	113	181
658	SKM.type_2_fast.oxidative_IIa	3.05e-06	Nonsignificant	0.06	1.11	Other	946	56
659	HEP.acute_phase.baseline	2.71e-06	Nonsignificant	0.98	0.97	Other	946	19
660	SKM.type_1_slow.contractile	2.59e-06	Nonsignificant	1.00	0.83	Other	596	8
661	EC.liver_sinusoidal.inflammatory	2.26e-06	Nonsignificant	—	0.00	Other	223	154
662	MAC.alveolar.lipid_autophagy	1.59e-06	Nonsignificant	—	0.16	Other	35	44
663	MONO.CD14.repair_M2_like	1.54e-06	Nonsignificant	0.98	0.89	Other	550	1,495
664	EPI.skin_interfollicular_spinous.baseline	1.50e-06	Nonsignificant	0.97	0.56	Other	35	3
665	DC.pDC.immature_metabolic	1.09e-06	Nonsignificant	0.80	0.95	Other	78	124
666	HEP.canalicular_transport.baseline	7.16e-07	Nonsignificant	1.00	0.67	Other	199	477
667	CM.translation_boost_RPL	6.96e-07	Nonsignificant	1.00	0.94	Other	129	1
668	NEU.EXC_IT.guidance	6.42e-07	Nonsignificant	0.94	0.75	Other	274	63
669	NEU.EXC_IT.callosal	5.84e-07	Nonsignificant	0.72	0.96	Other	286	119
670	MONO.CD14.cord_tolerance	5.68e-07	Nonsignificant	0.98	0.76	Other	864	753
671	MAC.kupffer.fibrogenic	4.28e-07	Nonsignificant	—	0.00	Other	0	0
672	NEU.INH_PVALB.neuromodulatory	4.23e-07	Nonsignificant	—	0.00	Other	0	0
673	EPI.skin_interfollicular_spinous.stress_UPR	2.34e-07	Nonsignificant	—	0.00	Other	0	0
674	DC.pDC.poised_migratory	2.19e-07	Nonsignificant	0.80	0.77	Other	54	95
675	SKM.type_1_slow.oxidative	1.97e-07	Nonsignificant	1.00	0.23	Other	802	251
676	HEP.acute_phase.complement_metabolic	1.04e-07	Nonsignificant	0.98	0.81	Other	1,423	3,464
677	HEP.acute_phase.inflammatory	4.47e-08	Nonsignificant	0.98	0.71	Other	382	649
678	HEP.acute_phase.hypoxia_lipid	1.06e-08	Nonsignificant	—	0.03	Other	0	0
679	NEU.EXC_CT.Ca2_signaling	1.06e-08	Nonsignificant	—	0.00	Other	68	17
680	MAC.alveolar.stress_metabolic	9.16e-09	Nonsignificant	0.91	0.97	Other	116	148
681	CM.anti_inflammatory	6.72e-09	Nonsignificant	1.00	0.82	Other	424	1,503
682	CM.translation_boost_RPS	4.63e-09	Nonsignificant	1.00	0.84	Other	69	16
683	NEU.EXC_NTNG1.synaptic	1.65e-10	Nonsignificant	—	0.67	Other	0	0
684	NEU.EXC_NTNG1.nuclear_reg	1.57e-10	Nonsignificant	—	0.00	Other	0	0
685	MAC.alveolar.biosynthetic_sterol_heme	1.68e-11	Nonsignificant	0.91	0.80	Other	347	40
686	MAC.alveolar.scavenging_endocytic	9.20e-13	Nonsignificant	—	0.00	Other	140	283
687	NEU.EXC_SYT2.nuclear_reg	4.49e-13	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_CT.Ca2_sensor	3.01e-13	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

54 unique genes. Showing 1–54. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
COLCA1	01-High	0.75	8.69	G1	C1	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic (L2), EPI.salivary_duct_excretory.baseline (L2), NEU.EXC_CT.remodeling (L2)	EPI.salivary_duct_excretory (Tier: specific) EPI.colonocyte.goblet_interface (Tier: relevant) EPI.ileal_goblet.immature (Tier: relevant) EPI.salivary_duct_excretory.baseline (Tier: relevant) EPI.salivary_duct_excretory.stress (Tier: relevant)	37 cells — complete matches	16	45
POU2AF3	01-High	0.72	8.31	G1	C1	—	—	—	16	43
RHPN2	01-High	0.57	10.14	G1	C1	—	EPI.colonocyte (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.ion_transport (Tier: relevant)	22 cells — complete matches	26	84
LAMA5	01-High	0.55	5.50	G1	C1	HEP.periportal_metabolic.urea_onecarbon_secretory (L2)	—	27 cells — complete matches	25	72
GPATCH1	01-High	0.54	10.73	G1	C1	—	—	12 cells — complete matches	25	83
CEP89	01-High	0.50	9.18	G1	C1	—	—	9 cells — complete matches	22	61
WDR88	01-High	0.48	8.90	G1	C1	—	—	—	72	313
FAAP24	01-High	0.48	9.11	G1	C1	—	—	22 cells — complete matches	22	60
SLC7A9	01-High	0.41	4.77	G1	C1	EPI.ileal_enterocyte_crypt.villus_transition (L2)	—	14 cells — complete matches	30	95
GREM1-AS1	02-Medium	0.53	13.28	G2	C2	—	—	—	0	0
GREM1	02-Medium	0.53	13.15	G2	C2	—	—	43 cells — complete matches	0	0
LINC01713	02-Medium	0.49	9.36	G1	C2	—	—	—	0	0
SCG5	02-Medium	0.49	11.99	G2	C2	IPSC.mesendo_primed (L2)	EPI.ileal_goblet.immature (Tier: relevant)	39 cells — complete matches	1	1
ENSG00000298379	02-Medium	0.46	11.79	G2	C2	—	—	—	2	1
SLC6A19	02-Medium	0.46	6.25	G2	C2	EPI.ileal_enterocyte_absorptive.brush_border (L2)	EPI.extrahepatic_cholangiocyte (Tier: relevant) EPI.bile_duct_cholangiocyte.secretory_mucin (Tier: relevant) EPI.extrahepatic_cholangiocyte.mucin_secretory (Tier: relevant)	11 cells — complete matches	5	15
SMAD7	02-Medium	0.45	10.79	G2	C2	—	—	39 cells — complete matches	2	3
ENSG00000287486	02-Medium	0.45	6.98	G2	C2	—	—	—	0	0
LAMA5-AS1	02-Medium	0.45	5.39	G1	C2	—	—	—	18	48
ENSG00000299449	02-Medium	0.43	12.59	G2	C2	—	—	—	2	5
ENSG00000298289	02-Medium	0.43	12.31	G2	C2	—	—	—	2	1
BMP2	02-Medium	0.43	7.81	G1	C2	—	EPI.colonocyte (Tier: specific) EPI.alveolar_type_2.injury_primed (Tier: specific) EPI.colonocyte.crypt_progenitor (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.inflammatory (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.junctional_remodel (Tier: relevant)	35 cells — complete matches	7	23
SLC6A18	02-Medium	0.42	5.48	G1	C2	—	—	EPI.renal_proximal_tubule (L1S), EPI.renal_proximal_tubule.detox_antioxidant (L2), EPI.renal_proximal_tubule.onecarbon_peroxisome (L2)	1	13
ENSG00000267764	02-Medium	0.42	12.11	G2	C2	—	—	—	2	1
ENSG00000300340	02-Medium	0.42	5.55	G1	C2	—	—	—	13	41
ENSG00000266905	02-Medium	0.41	12.17	G2	C2	—	—	—	1	0
ADRM1	02-Medium	0.41	5.57	G1	C2	—	—	EPI.alveolar_type_1.baseline (L2), MAC.resident_iron.heme_catabolism (L2)	17	48
EIF3H	02-Medium	0.40	3.27	G1	C2	—	—	GRANU.MAST (L1S), EPI.salivary_serous_acinar.secretory_active (L2)	0	0
ENSG00000289378	02-Medium	0.40	8.43	G2	C1	—	—	—	27	99
ENSG00000302641	02-Medium	0.40	6.11	G1	C2	—	—	—	0	0
ENSG00000293974	02-Medium	0.39	5.44	G1	C2	—	—	—	15	45
ENSG00000226332	02-Medium	0.38	5.08	G1	C2	—	—	—	17	44
TERT	02-Medium	0.38	7.73	G2	C2	—	EPI.thymic_cortical (Tier: specific) EPI.thymic_cortical.Notch_interface (Tier: specific)	10 cells — complete matches	0	2
ENSG00000309250	02-Medium	0.37	10.68	G2	C2	—	—	—	1	0
ENSG00000297684	02-Medium	0.36	6.68	G1	C2	—	—	—	0	0
LRP3	02-Medium	0.35	7.04	G2	C1	—	—	14 cells — complete matches	33	116
UTP23	02-Medium	0.35	3.31	G2	C2	—	—	DC.cDC2.adhesion_signaling (L2), GRANU.MAST.activated_acute (L2)	0	0
OSBPL2	02-Medium	0.35	3.92	G1	C2	—	—	EC.lymphatic.tip_migratory (L2), T.CD8_Tcm.helper_like (L2), T.CD8_Tem.signaling_turnover (L2)	17	46
ENSG00000273420	02-Medium	0.35	6.45	G2	C1	—	—	—	74	312
CTIF	02-Medium	0.35	8.59	G2	C2	—	EPI.salivary_serous_acinar.quiescent (Tier: specific)	25 cells — complete matches	2	1
ENSG00000298999	02-Medium	0.33	3.07	G2	C2	—	—	—	0	0
DYM-AS1	02-Medium	0.33	10.38	G2	C2	—	—	—	2	1
ENSG00000300381	02-Medium	0.32	4.76	G2	C2	—	—	—	0	0
RPS21-DT	02-Medium	0.31	5.49	G2	C2	—	—	—	12	39
CABLES2	02-Medium	0.31	5.77	G2	C2	—	—	4 cells — complete matches	12	39
POU2AF2	02-Medium	0.31	7.24	G2	C2	—	—	—	1	0
ENSG00000293761	02-Medium	0.30	4.81	G2	C2	—	—	—	11	38
RPS21	02-Medium	0.30	4.94	G2	C2	PERI.cardiac_skeletal (L2), SCHWN.translation_boost (L2)	EPI.pancreatic_ductal_progenitor (Tier: specific) EPI.pancreatic_ductal_perivascular (Tier: relevant) EPI.pancreatic_ductal_perivascular.protective_antioxidant (Tier: relevant) EPI.pancreatic_ductal_progenitor.baseline (Tier: relevant) EPI.pancreatic_ductal_progenitor.ciliated_transport (Tier: relevant)	64 cells — complete matches	14	50
RBBP8NL	02-Medium	0.30	5.28	G2	C2	—	—	6 cells — complete matches	8	34
ENSG00000267054	02-Medium	0.30	6.40	G2	C2	—	—	—	23	87
LINC02550	02-Medium	0.29	8.08	G2	C2	—	—	11 cells — complete matches	0	0
NUDT19	02-Medium	0.27	2.75	G2	C1	—	—	17 cells — complete matches	3	3
POU2AF1	02-Medium	0.24	7.04	G2	C2	T.CD4_Tfh.canonical_GC_helper (L2), T.CD4_Treg.Tr1_like (L2)	EPI.salivary_duct_excretory (Tier: specific) EPI.salivary_duct_excretory.baseline (Tier: relevant) EPI.salivary_duct_excretory.stress (Tier: relevant)	56 cells — complete matches	6	8
DYM	02-Medium	0.24	5.70	G2	C2	—	—	MAC.LAM.lipid_opsonization (L2), T.CD8_transitional.early (L2)	2	0
GOLGA8H	02-Medium	0.16	5.25	G2	C2	—	—	—	4	8

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.