Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000033 · All tissues

Acute tubulo-interstitial nephritis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Nephritis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	13.33	Significant	3.62e-28	1.14	Relevant	0	0
2	hepatocyte	7.24	Significant	3.62e-07	1.07	Other	1,515	3,822
3	oligodendrocyte	4.03	Nominal	0.90	1.02	Other	385	1,507
4	oligodendrocyte_precursor_cell	2.94	Nonsignificant	1.00	1.01	Other	461	1,454
5	neuron	2.90	Nonsignificant	1.00	0.99	Other	330	1,328
6	epithelial_cell	2.07	Nonsignificant	1.00	0.99	Other	24	47
7	fibroblast	1.95	Nonsignificant	1.00	0.98	Other	184	826
8	plasma_cell	0.92	Nonsignificant	1.00	0.92	Other	17	24
9	platelet	0.62	Nonsignificant	—	0.69	Other	85	104
10	mesothelial_cell	0.55	Nonsignificant	1.00	0.90	Other	6	36
11	chondrocyte	0.48	Nonsignificant	1.00	0.87	Other	548	1,069
12	astrocyte	0.42	Nonsignificant	1.00	0.86	Other	256	1,203
13	smooth_muscle_cell	0.28	Nonsignificant	1.00	0.80	Other	27	139
14	endothelial_cell	0.24	Nonsignificant	1.00	0.82	Other	373	974
15	granulocyte	0.18	Nonsignificant	1.00	0.89	Other	5	6
16	muscle_stem_cell	0.14	Nonsignificant	1.00	0.76	Other	7	27
17	innate_lymphoid_cell_2	0.10	Nonsignificant	1.00	0.80	Other	3	8
18	adipose_stem_and_progenitor_cell	0.09	Nonsignificant	1.00	0.76	Other	327	954
19	pericyte	0.09	Nonsignificant	1.00	0.75	Other	128	517
20	B_cell	0.08	Nonsignificant	1.00	0.70	Other	356	694
21	microglia	0.06	Nonsignificant	1.00	0.69	Other	61	129
22	melanocyte	0.04	Nonsignificant	1.00	0.62	Other	97	309
23	thymocyte	0.04	Nonsignificant	1.00	0.58	Other	168	512
24	cardiomyocyte	0.03	Nonsignificant	1.00	0.88	Other	533	2,045
25	granulosa_cell	0.03	Nonsignificant	1.00	0.58	Other	293	670
26	dendritic_cell	0.03	Nonsignificant	1.00	0.60	Other	496	724
27	macrophage	0.02	Nonsignificant	1.00	0.67	Other	813	1,732
28	T_cell	0.02	Nonsignificant	1.00	0.53	Other	470	959
29	schwann_cell	0.02	Nonsignificant	1.00	0.62	Other	10	57
30	haematopoietic_progenitor_cell	0.01	Nonsignificant	1.00	0.61	Other	262	502
31	natural_killer_cell	8.41e-03	Nonsignificant	1.00	0.48	Other	1,204	2,052
32	adipocyte	3.96e-03	Nonsignificant	1.00	0.47	Other	33	111
33	monocyte	1.71e-03	Nonsignificant	1.00	0.38	Other	2,176	3,871
34	skeletal_muscle_cell	1.33e-03	Nonsignificant	1.00	0.26	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.intrahepatic_cholangiocyte_transport	27.89	Significant	—	2.14	Relevant	12	42
2	EPI.pancreatic_ductal_bicarbonate	23.80	Significant	5.53e-06	1.27	Specific	131	548
3	HEP.acute_phase	16.37	Significant	1.19e-41	2.16	Specific	1,441	3,641
4	NEU.INH_LAMP5	14.91	Significant	6.43e-03	1.36	Specific	263	532
5	IPSC.induced_pluripotent_stem_cell	13.33	Significant	—	—	Relevant	0	0
6	EPI.pancreatic_ductal_perivascular	12.27	Significant	1.00	1.14	Relevant	4	30
7	EPI.hepatic_ductular_cholangiocyte	11.31	Significant	1.00	1.18	Relevant	83	243
8	EPI.intrahepatic_cholangiocyte_defense	10.37	Significant	—	1.51	Relevant	8	13
9	NEU.INH_PVALB	9.71	Significant	4.28e-03	1.31	Specific	193	183
10	NEU.EXC_NTNG1	7.83	Significant	—	1.05	Relevant	0	0
11	HEP.canalicular_transport	6.46	Significant	0.25	1.09	Specific	1,290	3,434
12	EPI.pancreatic_ductal_progenitor	6.25	Significant	1.00	1.13	Relevant	234	873
13	EPI.skin_appendage_keratinocyte	4.40	Nominal	1.00	1.09	Other	87	222
14	EPI.skin_sebaceous_duct_luminal	4.34	Nominal	1.00	1.11	Other	100	249
15	OLG.oligodendrocyte	4.03	Nominal	—	—	Other	384	1,397
16	EPI.endocervical_secretory	3.82	Nominal	—	1.04	Other	0	0
17	FIB.adventitial	3.73	Nominal	8.25e-39	1.73	Other	268	1,447
18	EPI.skin_keratinocyte_proliferating	3.47	Nominal	1.00	1.06	Other	47	76
19	NEU.INH_VIP	3.24	Nominal	1.00	0.96	Other	241	366
20	HEP.pericentral_lipoprotein	3.07	Nominal	—	0.00	Other	0	0
21	OPC.oligodendrocyte_precursor_cell	2.94	Nonsignificant	—	—	Other	413	1,269
22	EPI.pancreatic_islet	2.86	Nonsignificant	1.00	1.00	Other	52	132
23	FIB.skin_papillary	2.55	Nonsignificant	—	0.54	Other	0	0
24	EPI.pancreatic_ductal_mucinous	2.38	Nonsignificant	1.00	0.96	Other	219	430
25	FIB.skin_sheath	2.33	Nonsignificant	1.00	0.97	Other	49	118
26	EPI.extrahepatic_cholangiocyte	2.11	Nonsignificant	—	0.77	Other	37	71
27	NEU.EXC_CT	1.85	Nonsignificant	1.00	0.90	Other	362	384
28	FIB.skin_neurosecretory	1.85	Nonsignificant	—	0.35	Other	0	0
29	FIB.skin_tenogenic	1.70	Nonsignificant	—	0.30	Other	108	227
30	EPI.skin_hair_follicle_bulge	1.69	Nonsignificant	1.00	0.93	Other	51	178
31	EPI.skin_follicular_keratinizing	1.66	Nonsignificant	1.00	0.95	Other	30	81
32	EPI.renal_immature_ureteric_bud	1.64	Nonsignificant	1.00	0.88	Other	217	569
33	EPI.renal_proximal_tubule	1.64	Nonsignificant	1.00	1.05	Other	525	806
34	EC.heart_remodeling	1.60	Nonsignificant	1.81e-08	1.21	Other	569	1,594
35	HEP.periportal_metabolic	1.57	Nonsignificant	1.00	0.00	Other	1,750	4,427
36	EPI.skin_keratinocyte_progenitor	1.39	Nonsignificant	—	0.76	Other	0	3
37	EPI.tracheal_basal	1.17	Nonsignificant	1.00	0.91	Other	398	1,120
38	EPI.renal_distal_tubule	1.14	Nonsignificant	1.00	0.92	Other	133	361
39	FIB.barrier_purinergic	1.11	Nonsignificant	—	0.16	Other	1	3
40	FIB.transitioning	1.10	Nonsignificant	1.00	0.74	Other	172	497
41	EPI.salivary_duct_excretory	1.00	Nonsignificant	1.00	0.83	Other	85	180
42	PC.IgA_muocsal	1.00	Nonsignificant	3.33e-03	1.45	Other	18	31
43	EPI.tracheal_suprabasal	0.93	Nonsignificant	1.00	0.99	Other	29	56
44	EPI.ileal_enterocyte_crypt	0.88	Nonsignificant	1.00	0.77	Other	67	113
45	EPI.ectocervical_granular	0.85	Nonsignificant	—	0.11	Other	11	23
46	FIB.reticular	0.76	Nonsignificant	1.00	0.68	Other	19	87
47	EPI.renal_intercalated_cell_type_B	0.73	Nonsignificant	—	0.59	Other	6	7
48	EPI.skin_keratinocyte_basal	0.71	Nonsignificant	—	0.56	Other	13	26
49	EPI.tracheal_submucosal_gland	0.69	Nonsignificant	—	0.51	Other	0	0
50	FIB.suburothelial	0.67	Nonsignificant	1.00	0.75	Other	122	432
51	B.age_associated	0.65	Nonsignificant	0.02	1.35	Other	207	350
52	FIB.tracheal_subepithelial	0.62	Nonsignificant	—	0.00	Other	0	0
53	PLAT.platelet	0.62	Nonsignificant	—	0.00	Other	38	53
54	EPI.skin_sweat_duct_keratinocyte	0.56	Nonsignificant	1.00	0.89	Other	146	301
55	NEU.EXC_SYT2	0.56	Nonsignificant	—	0.00	Other	40	77
56	MESO.mesothelial_cell	0.55	Nonsignificant	—	—	Other	2	18
57	EPI.colonic_tuft	0.54	Nonsignificant	—	0.48	Other	7	24
58	EPI.colonic_enteroendocrine	0.50	Nonsignificant	—	0.37	Other	1	1
59	CHOND.chondrocyte	0.48	Nonsignificant	—	—	Other	519	730
60	EPI.renal_principal_cell	0.47	Nonsignificant	1.00	0.79	Other	207	403
61	FIB.lung_alveolar	0.44	Nonsignificant	—	0.00	Other	6	15
62	EPI.salivary_intercalated_defense	0.43	Nonsignificant	1.00	0.77	Other	81	161
63	ASTRO.astrocyte	0.42	Nonsignificant	—	—	Other	228	1,111
64	EPI.renal_intercalated_cell_type_A	0.35	Nonsignificant	1.00	0.73	Other	67	142
65	EC.lymphatic	0.35	Nonsignificant	0.26	1.12	Other	630	998
66	PC.IgG_systemic	0.34	Nonsignificant	0.90	0.79	Other	41	60
67	FIB.perivascular_interface	0.30	Nonsignificant	1.00	0.55	Other	0	0
68	EPI.ileal_enterocyte_absorptive	0.30	Nonsignificant	1.00	0.69	Other	118	338
69	EPI.bile_duct_cholangiocyte	0.30	Nonsignificant	1.00	0.74	Other	37	60
70	DC.mig	0.29	Nonsignificant	—	1.81	Other	89	156
71	GRANU.MAST	0.29	Nonsignificant	9.43e-04	1.72	Other	5	6
72	SMC.smooth_muscle_cell	0.28	Nonsignificant	—	—	Other	20	101
73	EPI.cervical_suprabasal	0.27	Nonsignificant	—	0.00	Other	14	50
74	NEU.EXC_IT	0.25	Nonsignificant	1.00	0.11	Other	411	192
75	EPI.colonocyte	0.25	Nonsignificant	1.00	0.68	Other	294	815
76	MAC.kupffer	0.19	Nonsignificant	0.25	1.26	Other	189	530
77	EPI.ileal_bile_transport	0.15	Nonsignificant	1.00	0.69	Other	61	93
78	MUSC.muscle_stem_cell	0.14	Nonsignificant	—	—	Other	4	18
79	FIB.interstitial	0.13	Nonsignificant	1.00	0.05	Other	288	940
80	T.CD4_Treg	0.13	Nonsignificant	0.12	1.18	Other	244	511
81	EPI.esophageal_basal	0.10	Nonsignificant	1.00	0.63	Other	4	10
82	ILC2.innate_lymphoid_cell_2	0.10	Nonsignificant	—	—	Other	2	0
83	FIB.neurolectin_mucosa	0.10	Nonsignificant	1.00	0.41	Other	133	394
84	ASPC.adipose_stem_and_progenitor_cell	0.09	Nonsignificant	—	—	Other	324	930
85	PERI.pericyte	0.09	Nonsignificant	—	—	Other	117	0
86	T.CD4_Tem	0.08	Nonsignificant	0.19	1.14	Other	365	697
87	EPI.salivary_myoepithelial	0.08	Nonsignificant	1.00	0.57	Other	191	714
88	EPI.ileal_goblet	0.08	Nonsignificant	1.00	0.64	Other	181	432
89	B.memory	0.07	Nonsignificant	1.00	1.00	Other	442	882
90	FIB.hepatic_stellate_cell	0.07	Nonsignificant	—	0.00	Other	64	252
91	EPI.skin_hair_follicle_companion	0.07	Nonsignificant	—	0.00	Other	8	12
92	EPI.renal_thick_ascending_limb	0.07	Nonsignificant	1.00	0.53	Other	453	1,153
93	EPI.lung_multiciliated	0.07	Nonsignificant	1.00	0.52	Other	16	49
94	MG.microglia	0.06	Nonsignificant	—	—	Other	49	0
95	B.naive	0.06	Nonsignificant	1.00	0.87	Other	307	595
96	EC.liver_sinusoidal	0.06	Nonsignificant	1.00	0.89	Other	1,083	1,925
97	T.CD4_Tfh	0.06	Nonsignificant	0.64	1.05	Other	47	45
98	T.CD4_Trm	0.06	Nonsignificant	0.32	1.08	Other	176	363
99	MAC.resident_iron	0.05	Nonsignificant	0.57	1.10	Other	16	21
100	EPI.salivary_duct_ion_transport	0.05	Nonsignificant	1.00	0.56	Other	5	11
101	EPI.skin_interfollicular_spinous	0.04	Nonsignificant	1.00	0.65	Other	260	563
102	T.CD8_transitional	0.04	Nonsignificant	0.32	1.07	Other	497	932
103	T.CD4_Th2	0.04	Nonsignificant	—	1.23	Other	1	2
104	EPI.salivary_serous_acinar	0.04	Nonsignificant	1.00	0.49	Other	233	531
105	EPI.esophageal_suprabasal	0.04	Nonsignificant	1.00	0.47	Other	158	404
106	MEL.melanocyte	0.04	Nonsignificant	—	—	Other	79	242
107	EPI.gastric_foveolar	0.04	Nonsignificant	—	0.00	Other	0	0
108	T.CD8_Trm	0.04	Nonsignificant	0.64	1.03	Other	211	346
109	THYMO.thymocyte	0.04	Nonsignificant	—	—	Other	163	495
110	EC.arterial	0.04	Nonsignificant	1.00	0.63	Other	356	885
111	MAC.LAM	0.03	Nonsignificant	0.08	1.13	Other	914	2,064
112	MAC.proliferating	0.03	Nonsignificant	0.57	1.17	Other	87	253
113	CM.cardiomyocyte	0.03	Nonsignificant	—	—	Other	524	2,032
114	DC.cDC1	0.03	Nonsignificant	0.80	1.14	Other	55	112
115	EC.venous	0.03	Nonsignificant	1.00	0.61	Other	516	1,387
116	GRNLSA.granulosa_cell	0.03	Nonsignificant	—	—	Other	257	0
117	EPI.pancreatic_acinar	0.03	Nonsignificant	1.00	0.57	Other	429	1,475
118	EPI.alveolar_type_1	0.03	Nonsignificant	1.00	0.48	Other	26	101
119	T.CD4_transitional	0.02	Nonsignificant	1.00	0.97	Other	48	110
120	EC.capillary	0.02	Nonsignificant	1.00	0.51	Other	514	1,635
121	EPI.lung_club_secretory	0.02	Nonsignificant	1.00	0.53	Other	5	14
122	DC.cDC2	0.02	Nonsignificant	1.00	0.80	Other	1,189	1,793
123	SCHWN.schwann_cell	0.02	Nonsignificant	—	—	Other	7	33
124	T.CD8_Tcm	0.02	Nonsignificant	1.00	0.98	Other	460	926
125	T.CD8_Tem	0.02	Nonsignificant	1.00	0.85	Other	1,083	1,857
126	MAC.microglia_like	0.02	Nonsignificant	0.76	1.07	Other	124	179
127	HPC.haematopoietic_progenitor_cell	0.01	Nonsignificant	—	—	Other	211	370
128	T.CD4_Tcm	0.01	Nonsignificant	1.00	0.95	Other	494	988
129	FIB.barrier_secretory	0.01	Nonsignificant	1.00	0.18	Other	81	228
130	T.gamma_delta	0.01	Nonsignificant	1.00	0.95	Other	588	1,078
131	T.CD4_Th17	9.10e-03	Nonsignificant	1.00	0.95	Other	421	794
132	NK.natural_killer_cell	8.41e-03	Nonsignificant	—	—	Other	1,204	2,045
133	MAC.resident_cardiac	6.51e-03	Nonsignificant	1.00	0.76	Other	485	1,074
134	EPI.alveolar_type_2	5.71e-03	Nonsignificant	1.00	0.16	Other	813	1,853
135	T.CD4_cytotoxic	5.55e-03	Nonsignificant	1.00	0.76	Other	855	1,493
136	T.CD4_naive	4.68e-03	Nonsignificant	1.00	0.71	Other	399	866
137	ADIPO.adipocyte	3.96e-03	Nonsignificant	—	—	Other	20	62
138	MAC.resident_repair	3.63e-03	Nonsignificant	1.00	0.70	Other	796	1,426
139	T.CD8_naive	3.44e-03	Nonsignificant	1.00	0.91	Other	317	708
140	EPI.thymic_medullary	2.85e-03	Nonsignificant	1.00	0.11	Other	26	133
141	T.MAIT	2.81e-03	Nonsignificant	0.12	1.16	Other	469	855
142	MAC.MDM	2.34e-03	Nonsignificant	1.00	0.65	Other	623	986
143	SKM.type_2_fast	2.18e-03	Nonsignificant	5.96e-16	1.64	Other	972	2,639
144	MONO.CD14	1.79e-03	Nonsignificant	0.72	1.01	Other	2,294	4,139
145	DC.pDC	1.49e-03	Nonsignificant	1.00	0.35	Other	496	1,028
146	EPI.salivary_mucous_acinar	1.45e-03	Nonsignificant	1.00	0.07	Other	639	1,189
147	MONO.CD16	1.34e-03	Nonsignificant	0.80	0.96	Other	1,304	1,835
148	GRANU.neutrophil	1.29e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
149	B.germinal_center	9.50e-04	Nonsignificant	1.00	0.04	Other	233	655
150	EPI.thymic_cortical	5.31e-04	Nonsignificant	1.00	0.38	Other	442	824
151	SKM.type_1_slow	1.85e-04	Nonsignificant	1.00	0.03	Other	923	2,478
152	MAC.alveolar	3.37e-05	Nonsignificant	1.00	8.89e-03	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	36.39	Significant	—	1.15	—	0	0
2	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	35.67	Significant	—	0.32	—	0	0
3	IPSC.canonical_pluripotent	35.13	Significant	1.10e-33	2.57	—	0	0
4	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	32.65	Significant	0.54	1.51	Relevant	40	191
5	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	32.52	Significant	—	0.93	Relevant	49	237
6	EPI.pancreatic_ductal_bicarbonate.stress	27.63	Significant	—	0.00	—	12	33
7	EPI.pancreatic_ductal_bicarbonate.activated	26.43	Significant	0.73	1.22	—	10	7
8	EPI.pancreatic_ductal_bicarbonate.baseline	23.62	Significant	0.84	0.85	Relevant	11	42
9	EPI.pancreatic_ductal_bicarbonate.inflammatory	23.31	Significant	0.84	0.82	Relevant	14	32
10	HEP.acute_phase.complement_metabolic	19.49	Significant	4.43e-07	3.04	Specific	1,423	3,464
11	EPI.hepatic_ductular_cholangiocyte.ion_transport	19.10	Significant	—	1.32	Relevant	0	0
12	EPI.hepatic_ductular_cholangiocyte.secretory_transport	17.26	Significant	—	0.81	—	0	0
13	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	17.21	Significant	—	0.00	Relevant	0	0
14	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	16.87	Significant	—	0.00	—	0	0
15	HEP.acute_phase.baseline	16.63	Significant	1.00	0.91	—	946	19
16	NEU.INH_LAMP5.glial_interface	15.96	Significant	—	0.13	Relevant	0	0
17	NEU.INH_LAMP5.exc_inh_balance	15.76	Significant	—	0.29	—	46	2
18	IPSC.mesendo_primed	15.35	Significant	0.13	1.28	—	0	0
19	HEP.acute_phase.hypoxia_lipid	15.01	Significant	—	0.00	Relevant	0	0
20	IPSC.stromal_primed	14.98	Significant	0.08	1.38	—	0	0
21	NEU.INH_LAMP5.projecting	14.90	Significant	—	0.00	—	0	0
22	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	14.49	Significant	1.00	0.00	Relevant	219	533
23	EPI.pancreatic_ductal_perivascular.protective_antioxidant	14.20	Significant	—	0.16	Relevant	11	69
24	EPI.hepatic_ductular_cholangiocyte.polarity	13.95	Significant	—	0.62	—	0	0
25	HEP.acute_phase.inflammatory	13.79	Significant	1.00	0.35	Relevant	382	649
26	HEP.acute_phase.stress_secretory	12.67	Significant	1.00	0.16	Relevant	26	3
27	NEU.INH_PVALB.metabotropic	12.50	Significant	—	0.77	—	0	0
28	HEP.acute_phase.complement_antiviral	12.47	Significant	1.00	0.04	Relevant	377	751
29	EPI.pancreatic_ductal_progenitor.ciliated_transport	12.33	Significant	—	1.24	Relevant	105	368
30	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	12.25	Significant	—	0.43	—	0	0
31	NEU.EXC_NTNG1.synaptic	12.18	Significant	—	0.67	Relevant	0	0
32	NEU.INH_LAMP5.rosehip	11.99	Significant	—	0.00	Relevant	0	0
33	IPSC.mesenchymal_primed	11.57	Significant	1.00	0.87	—	0	0
34	NEU.INH_PVALB.fastspike	11.28	Significant	—	0.40	—	24	22
35	EPI.pancreatic_ductal_perivascular.baseline	11.05	Significant	0.69	0.68	Relevant	1	5
36	EPI.skin_keratinocyte_proliferating.detox_repair	10.96	Significant	—	1.13	Relevant	0	0
37	NEU.INH_VIP.matrix	10.62	Significant	—	1.75	Specific	24	77
38	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	10.46	Significant	—	0.00	—	0	0
39	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	10.35	Significant	—	0.00	—	0	0
40	EPI.endocervical_secretory.squamous_barrier	10.30	Significant	—	0.67	Relevant	0	0
41	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	10.26	Significant	—	0.00	Relevant	0	0
42	NEU.INH_PVALB.serotonergic	9.94	Significant	—	0.28	—	0	0
43	NEU.INH_PVALB.neuromodulatory	9.86	Significant	—	0.27	—	0	0
44	IPSC.axial_identity_primed	9.85	Significant	1.00	0.50	—	0	0
45	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	9.57	Significant	—	1.44	Relevant	0	0
46	NEU.INH_PVALB.nuclear_reg	9.42	Significant	0.96	0.68	—	25	12
47	HEP.acute_phase.proliferative	8.98	Significant	—	0.00	Relevant	4	6
48	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	8.57	Significant	—	0.00	—	6	9
49	HEP.canalicular_transport.secretory_ERAD_UPR	8.22	Significant	0.05	1.69	—	232	28
50	HEP.canalicular_transport.inflammatory	8.13	Significant	1.06e-04	2.01	—	1,335	194
51	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	7.91	Significant	—	0.00	—	5	3
52	IPSC.proliferative	7.77	Significant	1.00	0.09	—	0	0
53	NEU.INH_PVALB.chandelier	7.75	Significant	0.96	0.19	—	19	16
54	NEU.INH_VIP.develop_niche	7.64	Significant	—	1.23	Relevant	0	0
55	IPSC.mesodermal_primed	6.98	Significant	1.00	0.24	—	0	0
56	OLG.myelinating_mature	6.87	Significant	1.34e-11	1.64	Specific	363	94
57	EPI.skin_appendage_keratinocyte.transit_amplifying	6.73	Significant	—	0.50	Specific	109	358
58	IPSC.midbrain_primed	6.71	Significant	1.00	0.29	Relevant	0	0
59	HEP.canalicular_transport.baseline	6.56	Significant	0.77	1.10	Relevant	199	477
60	IPSC.neural_primed	6.37	Significant	1.00	0.24	—	0	0
61	FIB.adventitial.baseline	6.22	Significant	1.28e-04	1.84	Specific	157	278
62	HEP.canalicular_transport.pericentral_like_hypoxia	5.95	Significant	1.00	0.69	—	326	8
63	ASPC.mesothelial_like	5.89	Significant	0.03	1.45	Other	143	486
64	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	5.86	Significant	—	0.17	—	0	0
65	NEU.INH_VIP.LAMP5_hybrid	5.85	Significant	—	0.81	Other	1	9
66	FIB.adventitial.mito_secretory	5.78	Significant	0.12	1.52	Relevant	21	7
67	NEU.INH_VIP.cannabinoid	5.74	Significant	—	0.84	Relevant	0	0
68	NEU.EXC_CT.Ca2_sensor	5.71	Significant	—	1.16	Relevant	0	0
69	OLG.myelinating_stress	5.67	Significant	0.31	1.17	Other	232	62
70	EPI.pancreatic_ductal_progenitor.baseline	5.57	Significant	0.75	0.70	Relevant	179	702
71	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	5.55	Significant	—	0.73	Relevant	39	82
72	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	5.37	Nominal	—	0.60	Other	0	0
73	EPI.hepatic_ductular_cholangiocyte.stress	5.08	Nominal	—	0.00	Other	0	0
74	FIB.adventitial.mechano_chemo_sensing	5.07	Nominal	0.09	1.43	Other	135	524
75	EPI.pancreatic_islet.beta	4.87	Nominal	0.20	1.31	Other	42	57
76	HEP.periportal_metabolic.apolipoprotein_secretory	4.78	Nominal	4.40e-04	1.74	Other	43	110
77	IPSC.neuroendocrine_primed	4.61	Nominal	—	0.00	Other	0	0
78	HEP.canalicular_transport.ductular_like_transition	4.58	Nominal	1.00	0.33	Other	400	87
79	OLG.vesicle_trafficking	4.53	Nominal	0.58	1.11	Other	124	10
80	IPSC.stress	4.43	Nominal	1.00	0.42	Other	0	0
81	EPI.skin_sebaceous_duct_luminal.detox_repair	4.38	Nominal	0.59	1.18	Other	137	94
82	HEP.canalicular_transport.sterol_lipid_biosynthesis	4.35	Nominal	—	0.00	Other	10	20
83	HEP.canalicular_transport.injury_stress	4.11	Nominal	1.00	0.00	Other	289	24
84	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	4.08	Nominal	0.59	0.90	Other	2	9
85	NEU.EXC_NTNG1.nuclear_reg	4.03	Nominal	—	0.00	Other	0	0
86	EPI.skin_hair_follicle_bulge.niche_crosstalk	4.00	Nominal	—	1.32	Other	29	88
87	FIB.adventitial.complement_angiocrine	3.86	Nominal	0.88	0.94	Other	153	684
88	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	3.84	Nominal	0.96	0.88	Other	33	34
89	EPI.extrahepatic_cholangiocyte.barrier_interface	3.76	Nominal	—	0.73	Other	0	0
90	EPI.skin_sebaceous_duct_luminal.immune_interface	3.57	Nominal	—	0.00	Other	0	0
91	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	3.56	Nominal	0.96	0.19	Other	7	16
92	EC.heart_remodeling.angiocrine	3.52	Nominal	1.95e-03	1.49	Other	182	525
93	EPI.renal_immature_ureteric_bud.defense_secretory	3.49	Nominal	0.07	1.47	Other	45	76
94	OPC.premyelinating	3.41	Nominal	0.15	1.62	Other	185	12
95	HEP.pericentral_lipoprotein.UPR_redox	3.41	Nominal	—	0.67	Other	0	0
96	NEU.EXC_CT.remodeling	3.13	Nominal	—	0.45	Other	23	1
97	EPI.ileal_enterocyte_crypt.proliferative_G2M	2.98	Nonsignificant	—	1.36	Other	19	54
98	HEP.periportal_metabolic.urea_onecarbon_secretory	2.87	Nonsignificant	4.40e-04	1.52	Other	1,332	3,053
99	EPI.pancreatic_ductal_progenitor.ADM_like	2.87	Nonsignificant	—	0.00	Other	0	0
100	FIB.skin_sheath.neuro_vascular_interface	2.81	Nonsignificant	—	0.80	Other	0	0
101	OPC.homeostatic	2.79	Nonsignificant	0.45	1.20	Other	394	160
102	EPI.skin_keratinocyte_proliferating.anchor_remodel	2.78	Nonsignificant	—	0.18	Other	0	0
103	NEU.INH_VIP.excitatory_coupled	2.76	Nonsignificant	—	0.21	Other	13	0
104	HEP.pericentral_lipoprotein.ApoB_coagulation	2.73	Nonsignificant	—	0.00	Other	0	0
105	IPSC.endoderm_primed	2.71	Nonsignificant	1.00	0.03	Other	0	0
106	NEU.INH_VIP.enkephalinergic	2.67	Nonsignificant	—	0.28	Other	0	0
107	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	2.65	Nonsignificant	—	1.52	Other	0	0
108	FIB.skin_papillary.baseline	2.55	Nonsignificant	—	0.00	Other	0	0
109	FIB.adventitial.adhesion_lipid	2.54	Nonsignificant	0.88	0.92	Other	58	209
110	OLG.stress	2.54	Nonsignificant	1.00	0.66	Other	232	8
111	OLG.regulatory_activated	2.52	Nonsignificant	1.00	0.62	Other	196	614
112	OPC.proliferative_immune_interact	2.52	Nonsignificant	0.87	0.58	Other	180	373
113	EPI.renal_distal_tubule.repair	2.50	Nonsignificant	—	0.55	Other	34	102
114	FIB.skin_sheath.ECM_immune	2.20	Nonsignificant	—	0.00	Other	0	0
115	FIB.adventitial.PI16_matrix	2.15	Nonsignificant	1.00	0.26	Other	70	90
116	EPI.skin_follicular_keratinizing.transit_amplifying	2.06	Nonsignificant	—	0.41	Other	21	49
117	EPI.renal_distal_tubule.ion_transport	2.06	Nonsignificant	—	0.71	Other	0	0
118	FIB.skin_sheath.stress_chaperone	2.00	Nonsignificant	—	0.00	Other	0	0
119	EPI.skin_keratinocyte_progenitor.activated_stress	1.87	Nonsignificant	—	0.38	Other	0	0
120	NEU.INH_VIP.regulatory_remodeling	1.86	Nonsignificant	—	0.00	Other	6	1
121	FIB.skin_neurosecretory.baseline	1.85	Nonsignificant	—	0.00	Other	0	0
122	OLG.regulatory	1.79	Nonsignificant	1.00	0.35	Other	353	73
123	NEU.INH_VIP.opioid	1.79	Nonsignificant	—	0.00	Other	50	9
124	EPI.ectocervical_granular.proliferative_basal	1.79	Nonsignificant	—	1.15	Other	0	0
125	EPI.salivary_duct_excretory.stress	1.73	Nonsignificant	7.66e-03	1.86	Other	33	68
126	HEP.periportal_metabolic.stress_chaperone	1.71	Nonsignificant	—	0.28	Other	66	128
127	FIB.skin_tenogenic.baseline	1.70	Nonsignificant	—	0.00	Other	0	2
128	EPI.renal_proximal_tubule.onecarbon_peroxisome	1.69	Nonsignificant	0.33	1.58	Other	58	89
129	FIB.adventitial.inflammatory_activated	1.68	Nonsignificant	1.00	0.17	Other	100	473
130	EPI.salivary_intercalated_defense.basal_EMT	1.67	Nonsignificant	—	1.49	Other	0	0
131	EPI.renal_proximal_tubule.detox_antioxidant	1.60	Nonsignificant	1.00	0.00	Other	394	77
132	EPI.tracheal_suprabasal.transitional_wound	1.54	Nonsignificant	—	0.60	Other	16	1
133	HEP.periportal_metabolic.canonical_urea_cycle	1.51	Nonsignificant	1.00	0.91	Other	1,464	269
134	EC.heart_remodeling.remodeling_secretory	1.49	Nonsignificant	1.00	0.92	Other	605	1,341
135	FIB.barrier_purinergic.lipid_secretory	1.46	Nonsignificant	—	0.48	Other	0	0
136	EPI.skin_follicular_keratinizing.root_infundibulum	1.45	Nonsignificant	—	0.00	Other	0	0
137	EPI.skin_follicular_keratinizing.upper_infundibulum	1.44	Nonsignificant	—	0.00	Other	8	2
138	EPI.skin_keratinocyte_basal.transit_amplifying	1.37	Nonsignificant	—	0.97	Other	0	0
139	NEU.INH_VIP.nuclear_reg	1.33	Nonsignificant	—	0.00	Other	20	4
140	EPI.tracheal_basal.homeostatic_progenitor	1.31	Nonsignificant	0.06	2.03	Other	285	74
141	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.28	Nonsignificant	0.76	0.66	Other	449	1,034
142	FIB.transitioning.matrix_stress	1.27	Nonsignificant	—	0.27	Other	47	138
143	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	1.26	Nonsignificant	—	0.00	Other	0	0
144	FIB.transitioning.ISG_primed_interface	1.22	Nonsignificant	—	0.25	Other	17	80
145	EPI.skin_hair_follicle_bulge.quiescent	1.21	Nonsignificant	0.89	0.48	Other	56	69
146	EPI.skin_keratinocyte_basal.spinous_transition	1.20	Nonsignificant	—	0.00	Other	0	0
147	PC.IgA_muocsal.migratory	1.15	Nonsignificant	0.53	1.08	Other	4	1
148	FIB.reticular.ECM_builder	1.14	Nonsignificant	—	0.44	Other	0	0
149	EPI.renal_distal_tubule.ciliated_remodelling	1.13	Nonsignificant	—	0.67	Other	0	0
150	NEU.INH_VIP.canonical_disinhibitory	1.11	Nonsignificant	0.98	0.22	Other	59	38
151	EPI.tracheal_submucosal_gland.ductal_luminal	1.09	Nonsignificant	—	0.00	Other	0	0
152	EPI.pancreatic_islet.alpha	1.08	Nonsignificant	—	0.00	Other	152	330
153	EPI.ileal_enterocyte_crypt.proliferative_S	1.05	Nonsignificant	0.69	1.30	Other	4	2
154	CHOND.remodeling	1.04	Nonsignificant	—	1.03	Other	5	0
155	PC.IgA_muocsal.plasmablast	1.01	Nonsignificant	0.53	1.15	Other	5	4
156	EPI.colonic_enteroendocrine.progenitor	1.01	Nonsignificant	—	0.97	Other	0	0
157	EPI.renal_immature_ureteric_bud.osmoprotective	1.00	Nonsignificant	0.99	0.33	Other	126	44
158	HEP.periportal_metabolic.xenobiotic_detox	0.99	Nonsignificant	1.00	0.92	Other	1,440	139
159	EPI.tracheal_basal.activated_stress	0.97	Nonsignificant	0.98	0.08	Other	32	0
160	PLAT.adhesion	0.96	Nonsignificant	—	0.48	Other	0	0
161	PC.IgA_muocsal.baseline	0.95	Nonsignificant	0.92	0.82	Other	3	5
162	FIB.transitioning.secretory_procollagen	0.95	Nonsignificant	—	0.00	Other	0	0
163	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.95	Nonsignificant	—	0.80	Other	0	0
164	ASTRO.immature_lipid	0.95	Nonsignificant	0.39	1.26	Other	23	113
165	HEP.periportal_metabolic.stress_checkpoint	0.91	Nonsignificant	1.00	0.70	Other	234	786
166	PC.IgA_muocsal.activated	0.87	Nonsignificant	0.83	0.96	Other	17	8
167	MESO.secretory_structural	0.85	Nonsignificant	—	0.32	Other	0	0
168	FIB.suburothelial.homeostasis_matrix	0.82	Nonsignificant	0.18	1.59	Other	258	921
169	MESO.activated_stress	0.81	Nonsignificant	—	0.67	Other	0	0
170	HEP.periportal_metabolic.acute_phase_barrier	0.79	Nonsignificant	1.00	0.49	Other	533	138
171	PC.IgG_systemic.secretory	0.77	Nonsignificant	0.13	1.30	Other	0	0
172	FIB.transitioning.motility_remodelling	0.77	Nonsignificant	—	0.00	Other	0	0
173	EPI.salivary_intercalated_defense.inflammatory	0.73	Nonsignificant	0.15	1.25	Other	152	360
174	FIB.reticular.stromal_niche	0.73	Nonsignificant	0.24	1.35	Other	0	0
175	EPI.renal_intercalated_cell_type_B.baseline	0.73	Nonsignificant	—	0.00	Other	3	1
176	ASTRO.hypoxia_angiogenic	0.73	Nonsignificant	0.62	1.20	Other	5	18
177	EC.lymphatic.valve	0.72	Nonsignificant	—	0.67	Other	0	0
178	NEU.EXC_IT.neuromodulated	0.71	Nonsignificant	0.76	1.05	Other	176	116
179	EPI.colonocyte.proximal_transport	0.70	Nonsignificant	0.62	1.23	Other	24	12
180	FIB.reticular.immune_interface	0.70	Nonsignificant	—	0.00	Other	1	6
181	B.age_associated.migratory	0.68	Nonsignificant	0.32	1.20	Other	2	2
182	FIB.suburothelial.urothelial_interface	0.68	Nonsignificant	0.18	1.46	Other	9	8
183	EPI.salivary_duct_excretory.baseline	0.67	Nonsignificant	1.00	0.00	Other	23	57
184	NEU.EXC_CT.projector	0.67	Nonsignificant	0.79	0.79	Other	87	26
185	NEU.INH_VIP.serotonergic	0.67	Nonsignificant	—	0.00	Other	9	2
186	FIB.barrier_purinergic.stress_GF_binding	0.67	Nonsignificant	—	0.00	Other	0	0
187	EPI.colonic_tuft.homeostatic	0.66	Nonsignificant	—	0.00	Other	0	0
188	MESO.antiviral	0.66	Nonsignificant	—	0.00	Other	3	8
189	EPI.renal_principal_cell.intercalated_like	0.65	Nonsignificant	0.14	1.62	Other	63	66
190	NEU.EXC_SYT2.synaptic	0.64	Nonsignificant	—	0.00	Other	0	0
191	NEU.EXC_IT.transitional	0.64	Nonsignificant	0.76	1.07	Other	237	142
192	EPI.renal_principal_cell.canonical_vasopressin	0.64	Nonsignificant	0.87	0.98	Other	2	0
193	B.age_associated.activated	0.64	Nonsignificant	—	0.12	Other	18	22
194	ASTRO.homeostatic	0.63	Nonsignificant	0.62	1.14	Other	200	431
195	EC.heart_remodeling.capillary_metabolic	0.63	Nonsignificant	1.00	0.99	Other	54	414
196	EPI.endocervical_secretory.secretory_translocon	0.62	Nonsignificant	—	0.00	Other	0	0
197	CM.contractile_oxphos	0.62	Nonsignificant	0.89	1.18	Other	6	19
198	FIB.reticular.stress_metallothionein	0.62	Nonsignificant	—	0.00	Other	3	32
199	FIB.tracheal_subepithelial.baseline	0.62	Nonsignificant	—	0.00	Other	0	0
200	EPI.renal_principal_cell.injury_repair	0.61	Nonsignificant	0.14	1.61	Other	26	9
201	CHOND.activated_fibro_like	0.61	Nonsignificant	0.44	1.18	Other	531	188
202	EC.lymphatic.activated	0.60	Nonsignificant	0.21	1.24	Other	47	73
203	B.age_associated.naive_transitional	0.59	Nonsignificant	—	0.00	Other	0	0
204	EPI.ileal_enterocyte_crypt.baseline	0.58	Nonsignificant	0.95	0.82	Other	11	6
205	NEU.EXC_IT.adhesion	0.58	Nonsignificant	0.71	1.12	Other	252	108
206	EPI.ileal_goblet.immature	0.58	Nonsignificant	—	1.59	Other	0	0
207	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.57	Nonsignificant	—	0.00	Other	0	0
208	FIB.lung_alveolar.mito_secretory	0.56	Nonsignificant	—	0.48	Other	0	0
209	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.55	Nonsignificant	—	0.76	Other	2	0
210	EPI.ileal_enterocyte_crypt.secretory_precursor	0.55	Nonsignificant	—	0.26	Other	0	0
211	MAC.kupffer.monocyte_like	0.54	Nonsignificant	—	1.29	Other	0	0
212	FIB.suburothelial.contractile_myofibroblast	0.54	Nonsignificant	—	0.00	Other	9	0
213	EPI.cervical_suprabasal.inflammatory_repair	0.54	Nonsignificant	—	0.42	Other	0	0
214	EC.heart_remodeling.translation_boost	0.53	Nonsignificant	—	0.00	Other	0	0
215	SMC.contractile	0.51	Nonsignificant	2.49e-03	1.40	Other	80	588
216	CHOND.angiogenic	0.51	Nonsignificant	—	0.39	Other	0	0
217	EPI.ileal_enterocyte_absorptive.villus_tip	0.49	Nonsignificant	3.37e-03	1.68	Other	4	3
218	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.48	Nonsignificant	—	0.00	Other	0	0
219	HEP.periportal_metabolic.inflammatory_activated	0.48	Nonsignificant	1.00	0.20	Other	712	1,610
220	EPI.colonocyte.secretory_boost	0.47	Nonsignificant	0.80	1.11	Other	98	91
221	EPI.colonic_enteroendocrine.Lcell_peptide	0.46	Nonsignificant	—	0.00	Other	0	0
222	EC.lymphatic.tip_migratory	0.46	Nonsignificant	0.21	1.23	Other	23	37
223	FIB.suburothelial.inflammatory_prostanoid	0.44	Nonsignificant	—	0.00	Other	0	0
224	EPI.colonic_tuft.activated	0.43	Nonsignificant	—	0.00	Other	0	0
225	NEU.EXC_SYT2.nuclear_reg	0.42	Nonsignificant	—	0.00	Other	0	0
226	EPI.renal_intercalated_cell_type_A.PC_transitional	0.41	Nonsignificant	—	0.03	Other	203	407
227	FIB.perivascular_interface.vascular_BM_remodelling	0.40	Nonsignificant	—	0.30	Other	0	0
228	EC.heart_remodeling.remodeling_stalk	0.40	Nonsignificant	1.00	0.56	Other	33	111
229	MAC.kupffer.stress	0.39	Nonsignificant	0.23	1.21	Other	9	3
230	CHOND.articular_collagen	0.39	Nonsignificant	0.95	0.94	Other	551	266
231	ASTRO.stress_acute	0.38	Nonsignificant	0.39	1.28	Other	60	56
232	GRANU.MAST.activated_acute	0.38	Nonsignificant	—	0.50	Other	0	0
233	MESO.baseline	0.37	Nonsignificant	0.83	0.71	Other	0	6
234	ASTRO.synaptic_interaction	0.35	Nonsignificant	0.87	0.94	Other	76	334
235	EPI.renal_intercalated_cell_type_A.acid_secretion	0.34	Nonsignificant	0.60	0.89	Other	12	6
236	MESO.activated_migratory	0.33	Nonsignificant	—	0.00	Other	0	0
237	EPI.lung_multiciliated.mature_motile_cilia	0.32	Nonsignificant	—	1.53	Other	0	0
238	FIB.adventitial.activated_remodelling	0.32	Nonsignificant	—	0.00	Other	141	319
239	ASTRO.stress_mito	0.32	Nonsignificant	0.76	1.01	Other	47	110
240	ASPC.signal_integrator	0.31	Nonsignificant	—	0.24	Other	0	0
241	ASTRO.A2_reactive	0.31	Nonsignificant	0.89	0.82	Other	10	37
242	EC.lymphatic.baseline	0.30	Nonsignificant	0.70	0.97	Other	38	72
243	GRANU.MAST.activated_repair	0.30	Nonsignificant	—	0.08	Other	0	1
244	EPI.colonocyte.distal_absorptive	0.29	Nonsignificant	—	0.54	Other	0	0
245	DC.mig.baseline	0.29	Nonsignificant	—	0.00	Other	1	0
246	FIB.interstitial.mesenchymal_regulator	0.29	Nonsignificant	0.73	1.09	Other	4	4
247	T.CD4_Tem.transitional_CM	0.29	Nonsignificant	0.01	1.40	Other	31	20
248	EPI.tracheal_submucosal_gland.acinar_serous	0.28	Nonsignificant	—	0.00	Other	0	0
249	EPI.pancreatic_islet.delta	0.28	Nonsignificant	—	0.00	Other	0	0
250	T.CD4_Treg.tissue_effector	0.27	Nonsignificant	0.12	1.36	Other	16	13
251	FIB.lung_alveolar.stress_interacting	0.27	Nonsignificant	—	0.00	Other	0	0
252	EC.heart_remodeling.activated_acute	0.27	Nonsignificant	1.00	0.39	Other	102	186
253	FIB.perivascular_interface.vasomotor_tone	0.26	Nonsignificant	—	0.00	Other	0	0
254	NEU.EXC_CT.Ca2_signaling	0.24	Nonsignificant	—	0.00	Other	68	17
255	FIB.perivascular_interface.lipid_shuttle	0.24	Nonsignificant	—	0.00	Other	51	170
256	ASTRO.A1_reactive	0.23	Nonsignificant	0.62	1.07	Other	433	394
257	GRANU.MAST.resting_granule	0.23	Nonsignificant	—	0.00	Other	0	0
258	FIB.interstitial.remodeling	0.23	Nonsignificant	0.73	1.07	Other	31	9
259	EPI.renal_principal_cell.inflammatory	0.23	Nonsignificant	0.99	0.19	Other	74	157
260	EPI.renal_principal_cell.activated_acute	0.22	Nonsignificant	0.99	0.24	Other	29	59
261	EPI.skin_interfollicular_spinous.transition_basal	0.22	Nonsignificant	0.37	1.21	Other	100	127
262	CHOND.pro_inflammatory	0.21	Nonsignificant	0.99	0.50	Other	181	351
263	MUSC.quiescent_reservoir	0.21	Nonsignificant	0.71	1.30	Other	2	8
264	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.20	Nonsignificant	—	0.00	Other	0	0
265	SMC.metabolic	0.20	Nonsignificant	0.94	0.73	Other	14	40
266	EPI.ileal_bile_transport.detox_transcytosis	0.20	Nonsignificant	—	0.80	Other	0	1
267	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.20	Nonsignificant	—	0.22	Other	43	26
268	EPI.ileal_enterocyte_crypt.bile_transport	0.19	Nonsignificant	0.95	0.31	Other	2	0
269	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.18	Nonsignificant	—	0.00	Other	135	290
270	B.naive.metabolic	0.18	Nonsignificant	0.59	1.22	Other	50	79
271	MEL.dedifferentiated_migratory	0.17	Nonsignificant	—	0.76	Other	0	0
272	ILC2.activated	0.16	Nonsignificant	—	0.59	Other	0	0
273	PERI.baseline	0.16	Nonsignificant	9.84e-03	1.60	Other	39	66
274	MG.expanding	0.15	Nonsignificant	0.22	1.41	Other	2	1
275	PC.IgG_systemic.interacting	0.15	Nonsignificant	0.81	0.80	Other	0	0
276	EPI.colonocyte.crypt_progenitor	0.15	Nonsignificant	1.00	0.80	Other	115	265
277	B.naive.baseline	0.15	Nonsignificant	0.59	1.16	Other	10	13
278	EPI.renal_thick_ascending_limb.salt_sensing	0.15	Nonsignificant	0.43	1.27	Other	73	103
279	MUSC.early_activation	0.14	Nonsignificant	0.95	0.83	Other	4	32
280	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.14	Nonsignificant	—	0.97	Other	0	0
281	EC.liver_sinusoidal.hypoxia_metabolic	0.14	Nonsignificant	0.59	1.15	Other	183	107
282	FIB.interstitial.mesenchymal_APC	0.14	Nonsignificant	0.91	0.96	Other	81	33
283	B.memory.pDC_imprint	0.14	Nonsignificant	0.38	1.27	Other	157	103
284	ILC2.migratory	0.14	Nonsignificant	—	0.44	Other	0	0
285	ASPC.niche_keeping_progenitor	0.14	Nonsignificant	0.87	1.11	Other	52	219
286	MUSC.baseline	0.13	Nonsignificant	0.95	0.99	Other	0	0
287	PC.IgG_systemic.metabolic	0.13	Nonsignificant	0.81	0.82	Other	46	63
288	EPI.ileal_bile_transport.absorptive_xenobiotic	0.13	Nonsignificant	0.94	0.11	Other	11	12
289	T.CD4_Treg.APC_interactive	0.13	Nonsignificant	0.82	0.98	Other	118	28
290	EC.venous.cardiac_structural	0.13	Nonsignificant	0.41	1.32	Other	102	229
291	T.CD4_Tcm.regulatory_poised	0.12	Nonsignificant	0.16	1.32	Other	2	3
292	B.naive.receptor_recycle	0.12	Nonsignificant	0.59	1.16	Other	51	0
293	THYMO.SP_CD4_naive	0.12	Nonsignificant	0.25	1.36	Other	65	75
294	FIB.neurolectin_mucosa.axon_responsive	0.12	Nonsignificant	0.36	1.23	Other	10	10
295	T.CD4_Treg.Tr1_like	0.12	Nonsignificant	—	0.11	Other	8	8
296	EPI.pancreatic_acinar.stress	0.12	Nonsignificant	0.49	1.40	Other	28	28
297	FIB.neurolectin_mucosa.inflammatory	0.11	Nonsignificant	0.36	1.25	Other	52	110
298	FIB.interstitial.immune_interact	0.11	Nonsignificant	0.91	0.99	Other	12	1
299	EPI.ileal_enterocyte_absorptive.brush_border	0.11	Nonsignificant	1.00	0.00	Other	580	1,717
300	T.CD4_Trm.baseline	0.11	Nonsignificant	0.72	1.16	Other	31	21
301	EPI.esophageal_basal.activated_progenitor	0.11	Nonsignificant	0.15	1.51	Other	1	0
302	THYMO.proliferative_S	0.11	Nonsignificant	0.08	1.43	Other	163	418
303	FIB.hepatic_stellate_cell.fibrogenic	0.11	Nonsignificant	—	0.73	Other	0	0
304	EPI.tracheal_suprabasal.secretory_immune	0.10	Nonsignificant	—	0.00	Other	0	0
305	EPI.skin_keratinocyte_basal.basement_anchoring	0.10	Nonsignificant	—	0.00	Other	0	0
306	T.CD8_Trm.muscosal_Tc17	0.10	Nonsignificant	0.28	1.30	Other	19	38
307	FIB.neurolectin_mucosa.remodeling_repair	0.10	Nonsignificant	—	0.26	Other	4	2
308	MAC.resident_iron.stress_tolerogenic	0.10	Nonsignificant	—	0.74	Other	0	0
309	DC.cDC2.proliferative	0.10	Nonsignificant	—	0.84	Other	39	71
310	EPI.ectocervical_granular.inflammatory	0.10	Nonsignificant	—	0.32	Other	0	0
311	T.CD4_Tfh.precursor_migratory	0.09	Nonsignificant	0.06	1.38	Other	72	27
312	EPI.renal_thick_ascending_limb.remodeling	0.09	Nonsignificant	0.84	1.07	Other	152	92
313	EPI.ileal_enterocyte_crypt.villus_transition	0.09	Nonsignificant	—	0.00	Other	7	10
314	EPI.salivary_myoepithelial.baseline	0.09	Nonsignificant	0.19	1.38	Other	42	141
315	T.CD8_transitional.APC_like	0.09	Nonsignificant	2.67e-06	1.50	Other	205	62
316	MAC.resident_iron.redox_metabolic	0.09	Nonsignificant	0.65	1.23	Other	4	4
317	ASTRO.neuromodulatory	0.08	Nonsignificant	1.00	0.31	Other	34	172
318	EPI.salivary_myoepithelial.contractile_repair	0.08	Nonsignificant	—	0.00	Other	3	9
319	EC.liver_sinusoidal.prostanoid	0.08	Nonsignificant	—	0.64	Other	11	64
320	B.memory.baseline	0.08	Nonsignificant	0.43	1.06	Other	472	99
321	EC.arterial.arteriole_interface	0.08	Nonsignificant	0.32	1.31	Other	31	12
322	EPI.salivary_myoepithelial.junctional_transport	0.08	Nonsignificant	0.09	1.68	Other	66	121
323	T.CD8_Tcm.NK_like	0.08	Nonsignificant	0.22	1.23	Other	334	581
324	B.memory.activated	0.08	Nonsignificant	0.38	1.14	Other	105	29
325	T.CD4_Tfh.canonical_GC_helper	0.07	Nonsignificant	0.50	1.25	Other	1	2
326	THYMO.SP_CD8_transitional	0.07	Nonsignificant	0.29	1.36	Other	32	75
327	B.naive.activated	0.07	Nonsignificant	0.59	1.12	Other	77	127
328	EPI.esophageal_basal.junctional_barrier	0.07	Nonsignificant	—	0.00	Other	0	0
329	PERI.cardiac_skeletal	0.07	Nonsignificant	1.00	0.72	Other	313	630
330	T.CD4_Tcm.APC_mimicry	0.07	Nonsignificant	0.88	1.19	Other	54	43
331	PERI.inflammatory	0.07	Nonsignificant	1.00	0.93	Other	40	77
332	EC.arterial.homeostatic	0.07	Nonsignificant	0.32	1.30	Other	24	3
333	EPI.esophageal_suprabasal.proliferative_exit	0.07	Nonsignificant	—	0.99	Other	0	0
334	MAC.kupffer.fibrogenic	0.07	Nonsignificant	—	0.07	Other	0	0
335	T.CD4_Tem.cytotoxic_effector	0.07	Nonsignificant	0.50	1.14	Other	225	398
336	EPI.lung_club_secretory.ciliogenesis_axoneme	0.07	Nonsignificant	—	0.34	Other	0	0
337	SMC.activated	0.07	Nonsignificant	0.94	0.76	Other	2	5
338	EPI.salivary_myoepithelial.activated	0.06	Nonsignificant	0.78	0.73	Other	85	281
339	FIB.interstitial.stress_secretory	0.06	Nonsignificant	0.91	0.90	Other	92	56
340	T.CD4_Trm.central_like	0.06	Nonsignificant	0.83	1.09	Other	38	31
341	EPI.lung_multiciliated.baseline	0.06	Nonsignificant	—	0.51	Other	0	7
342	T.CD4_Trm.helper_like	0.06	Nonsignificant	1.00	0.95	Other	84	147
343	EPI.renal_thick_ascending_limb.barrier_repair	0.06	Nonsignificant	0.84	0.99	Other	141	284
344	MAC.LAM.inflammatory_APC	0.06	Nonsignificant	0.71	1.13	Other	872	165
345	EPI.renal_thick_ascending_limb.cation_flux	0.06	Nonsignificant	0.86	0.92	Other	57	95
346	B.memory.migratory	0.06	Nonsignificant	0.49	1.04	Other	123	208
347	PERI.angiocrine	0.05	Nonsignificant	1.00	0.26	Other	93	102
348	B.naive.purinergic	0.05	Nonsignificant	0.59	1.05	Other	384	820
349	T.CD4_Th2.precursor	0.05	Nonsignificant	—	0.48	Other	0	0
350	ASPC.inflammatory	0.05	Nonsignificant	0.87	1.17	Other	21	61
351	EPI.esophageal_suprabasal.basal_transitional	0.05	Nonsignificant	0.07	1.61	Other	44	67
352	MEL.secretory_quiescent	0.05	Nonsignificant	0.63	1.20	Other	19	13
353	MG.baseline	0.05	Nonsignificant	0.87	0.89	Other	16	5
354	MEL.neurotrophic_migratory	0.05	Nonsignificant	—	0.81	Other	0	0
355	EC.capillary.activated	0.05	Nonsignificant	0.11	1.45	Other	2	5
356	MAC.kupffer.inflammatory	0.05	Nonsignificant	—	0.00	Other	7	4
357	EPI.esophageal_suprabasal.proliferative_G2M	0.05	Nonsignificant	—	0.41	Other	0	0
358	MAC.resident_iron.APC_iron_sensing	0.05	Nonsignificant	0.73	0.90	Other	211	114
359	EC.heart_remodeling.perivascular	0.05	Nonsignificant	1.00	0.08	Other	124	408
360	NK.adaptive_immature_precursor	0.05	Nonsignificant	0.32	1.22	Other	358	111
361	EPI.colonocyte.ionocyte_BEST4	0.05	Nonsignificant	1.00	0.56	Other	103	188
362	DC.cDC1.cross_presenting	0.05	Nonsignificant	—	1.01	Other	0	0
363	MAC.proliferating.stress	0.05	Nonsignificant	—	0.00	Other	87	136
364	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.05	Nonsignificant	—	0.00	Other	0	0
365	EPI.salivary_duct_ion_transport.baseline	0.05	Nonsignificant	—	—	Other	0	0
366	EPI.alveolar_type_1.activated	0.05	Nonsignificant	—	1.64	Other	0	0
367	EPI.salivary_serous_acinar.quiescent	0.05	Nonsignificant	0.19	1.48	Other	178	493
368	T.CD4_Treg.central_naive_like	0.05	Nonsignificant	0.87	0.79	Other	333	45
369	THYMO.CD8aa_IELp	0.05	Nonsignificant	—	0.66	Other	1	7
370	NEU.EXC_IT.callosal	0.04	Nonsignificant	1.00	0.73	Other	286	119
371	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.04	Nonsignificant	—	0.00	Other	0	0
372	T.CD8_Trm.inflammatory	0.04	Nonsignificant	0.67	1.10	Other	124	176
373	FIB.hepatic_stellate_cell.contractile	0.04	Nonsignificant	—	0.00	Other	0	0
374	FIB.neurolectin_mucosa.nerve_interface	0.04	Nonsignificant	—	0.00	Other	4	0
375	T.CD4_Trm.metal_stress	0.04	Nonsignificant	0.83	1.16	Other	34	58
376	GRNLSA.chemokine_mechanosensory	0.04	Nonsignificant	0.19	1.59	Other	1	0
377	MAC.resident_iron.heme_catabolism	0.04	Nonsignificant	0.65	1.11	Other	30	51
378	DC.cDC2.antiviral	0.04	Nonsignificant	1.00	1.15	Other	100	37
379	EC.capillary.inflammatory	0.04	Nonsignificant	0.61	1.15	Other	27	51
380	EPI.salivary_serous_acinar.secretory_active	0.04	Nonsignificant	0.89	0.86	Other	242	69
381	EPI.skin_hair_follicle_bulge.anagen_growth	0.04	Nonsignificant	—	0.00	Other	0	0
382	ASPC.adipocyte_capillary_interface	0.04	Nonsignificant	0.95	1.07	Other	21	54
383	MAC.kupffer.tolerogenic	0.04	Nonsignificant	—	0.00	Other	45	49
384	FIB.hepatic_stellate_cell.inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
385	SCHWN.translation_boost	0.04	Nonsignificant	—	0.27	Other	8	1
386	T.CD4_transitional.primed_helper_effector	0.04	Nonsignificant	0.78	1.11	Other	19	43
387	EC.liver_sinusoidal.inflammatory	0.04	Nonsignificant	—	0.00	Other	223	154
388	T.CD8_Trm.dendritic_recruiter	0.04	Nonsignificant	0.67	1.06	Other	47	85
389	CM.baseline	0.04	Nonsignificant	1.00	1.00	Other	393	0
390	THYMO.SP_CD8_naive_stress	0.04	Nonsignificant	0.29	1.35	Other	1	1
391	MG.phagocytic_APC	0.04	Nonsignificant	0.87	0.70	Other	25	8
392	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.04	Nonsignificant	1.00	0.12	Other	11	22
393	T.CD8_naive.mito_proteostasis	0.04	Nonsignificant	0.32	1.27	Other	428	100
394	EPI.gastric_foveolar.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
395	MAC.microglia_like.phagocytic_redox	0.04	Nonsignificant	—	0.32	Other	0	0
396	EPI.pancreatic_acinar.metabolic_onecarbon	0.04	Nonsignificant	1.00	1.08	Other	287	328
397	DC.cDC2.lipid_metabolic	0.04	Nonsignificant	—	0.99	Other	0	0
398	GRNLSA.proliferative_migratory	0.04	Nonsignificant	0.19	1.45	Other	248	292
399	DC.cDC1.activated	0.04	Nonsignificant	—	0.20	Other	0	0
400	EPI.esophageal_suprabasal.differentiating_keratin	0.03	Nonsignificant	0.91	0.52	Other	131	61
401	SCHWN.reactive_inflammatory	0.03	Nonsignificant	—	0.73	Other	0	0
402	ASPC.preadipocyte_lipid_primed	0.03	Nonsignificant	0.98	0.94	Other	331	129
403	T.CD8_transitional.effector_primed	0.03	Nonsignificant	0.99	0.74	Other	435	151
404	EC.venous.baseline	0.03	Nonsignificant	0.41	1.09	Other	346	807
405	EPI.esophageal_suprabasal.proliferative_S	0.03	Nonsignificant	—	0.00	Other	26	41
406	T.CD4_transitional.APC_interacting	0.03	Nonsignificant	0.78	1.03	Other	10	14
407	EC.arterial.ion_pump	0.03	Nonsignificant	1.00	1.03	Other	3	2
408	B.naive.antigen_presenting_ready	0.03	Nonsignificant	0.99	0.92	Other	48	73
409	T.CD8_Trm.homeostatic	0.03	Nonsignificant	0.81	0.95	Other	42	5
410	GRNLSA.secretory_remodeling	0.03	Nonsignificant	0.36	1.31	Other	90	25
411	T.CD4_Tfh.suppression_exhaustion	0.03	Nonsignificant	1.00	0.76	Other	0	2
412	DC.cDC1.proliferative	0.03	Nonsignificant	—	0.00	Other	0	0
413	T.CD4_naive.activated_stress	0.03	Nonsignificant	0.67	1.23	Other	339	429
414	ASPC.secretory	0.03	Nonsignificant	0.99	0.91	Other	76	5
415	ASPC.proliferative	0.03	Nonsignificant	0.95	1.02	Other	33	85
416	EC.arterial.metabolic	0.03	Nonsignificant	1.00	0.98	Other	195	159
417	HPC.LMPP	0.03	Nonsignificant	0.51	1.13	Other	65	31
418	T.CD4_transitional.tissue_enagement	0.03	Nonsignificant	0.78	1.09	Other	5	11
419	EPI.bile_duct_cholangiocyte.secretory_mucin	0.03	Nonsignificant	—	0.00	Other	7	12
420	EC.capillary.baseline	0.03	Nonsignificant	0.66	1.08	Other	246	560
421	T.CD8_transitional.Trm_primed	0.03	Nonsignificant	0.99	0.82	Other	108	15
422	MUSC.activated_migratory	0.03	Nonsignificant	0.99	0.10	Other	6	7
423	NK.cytokine_tissue_resident	0.03	Nonsignificant	0.71	1.16	Other	74	82
424	THYMO.proliferative_G2M	0.03	Nonsignificant	—	0.25	Other	164	413
425	MONO.CD14.platelet_bound	0.02	Nonsignificant	0.74	1.14	Other	964	176
426	EPI.lung_club_secretory.inflammatory	0.02	Nonsignificant	—	0.79	Other	0	0
427	T.CD8_Tem.stress_adapted	0.02	Nonsignificant	0.31	1.31	Other	607	520
428	MAC.proliferating.DNA_replication	0.02	Nonsignificant	0.71	0.93	Other	3	6
429	T.CD4_Th2.tissue_adapted	0.02	Nonsignificant	—	0.00	Other	0	0
430	GRNLSA.p53_damage	0.02	Nonsignificant	—	0.17	Other	13	10
431	EPI.alveolar_type_1.baseline	0.02	Nonsignificant	1.00	0.00	Other	8	0
432	THYMO.DP_early	0.02	Nonsignificant	1.00	0.70	Other	326	313
433	PLAT.megakaryocytic	0.02	Nonsignificant	—	0.00	Other	0	0
434	HPC.CLP_B_primed	0.02	Nonsignificant	—	0.94	Other	0	0
435	EC.capillary.angiocrine	0.02	Nonsignificant	0.66	1.06	Other	250	630
436	MAC.microglia_like.patrolling_adhesive	0.02	Nonsignificant	—	0.69	Other	0	0
437	EPI.ileal_goblet.baseline	0.02	Nonsignificant	0.83	0.95	Other	16	2
438	T.CD8_transitional.early	0.02	Nonsignificant	0.99	0.69	Other	327	55
439	NK.immature_bridge	0.02	Nonsignificant	0.32	1.16	Other	117	122
440	GRNLSA.EMT_insulin_signaling	0.02	Nonsignificant	0.93	0.90	Other	47	84
441	T.CD4_cytotoxic.precursor	0.02	Nonsignificant	0.13	1.48	Other	156	67
442	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.95	0.73	Other	28	6
443	EPI.ectocervical_granular.secretory_apocrine	0.02	Nonsignificant	—	0.00	Other	0	0
444	GRNLSA.lipid_hypoxia	0.02	Nonsignificant	0.93	0.76	Other	28	0
445	DC.cDC1.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
446	FIB.barrier_secretory.remodeling	0.02	Nonsignificant	—	0.64	Other	0	0
447	T.CD4_Tem.long_term_memory	0.02	Nonsignificant	0.50	1.03	Other	314	587
448	T.CD8_Tem.TEMRA	0.02	Nonsignificant	0.53	1.21	Other	920	1,088
449	B.naive.remodeling	0.02	Nonsignificant	0.99	0.71	Other	135	230
450	T.CD4_Th17.cytotoxic	0.02	Nonsignificant	0.38	1.18	Other	332	123
451	B.memory.preactivated	0.02	Nonsignificant	0.49	1.02	Other	173	174
452	EC.venous.quiescent_homeostatic	0.02	Nonsignificant	0.91	1.03	Other	456	360
453	DC.cDC1.homeostatic_inhibitory	0.02	Nonsignificant	—	0.00	Other	0	0
454	EC.arterial.arteriole_gas_exchange	0.02	Nonsignificant	1.00	0.65	Other	238	131
455	T.CD4_transitional.baseline	0.02	Nonsignificant	0.78	0.88	Other	59	97
456	EC.arterial.angiogenic_tip	0.02	Nonsignificant	—	0.00	Other	30	37
457	HPC.GMP_inflammatory	0.02	Nonsignificant	0.51	1.27	Other	20	10
458	T.CD4_transitional.primed_cytotoxic	0.02	Nonsignificant	0.78	0.90	Other	28	30
459	EC.arterial.mito_contact	0.02	Nonsignificant	1.00	0.77	Other	14	5
460	EPI.renal_distal_tubule.stress	0.02	Nonsignificant	—	0.00	Other	0	0
461	THYMO.DP_early_stress	0.02	Nonsignificant	—	0.36	Other	0	0
462	EPI.ileal_goblet.inflammatory_mucin	0.02	Nonsignificant	0.83	0.38	Other	6	9
463	NK.adaptive_adipose_stress	0.02	Nonsignificant	0.97	1.05	Other	374	39
464	B.naive.restrained	0.02	Nonsignificant	0.99	0.65	Other	183	353
465	T.CD8_transitional.stress	0.02	Nonsignificant	—	0.00	Other	24	34
466	T.CD8_Tcm.helper_like	0.02	Nonsignificant	0.56	1.03	Other	81	159
467	FIB.interstitial.lipid_matrix	0.02	Nonsignificant	1.00	0.58	Other	258	191
468	EC.arterial.elastic	0.02	Nonsignificant	1.00	0.77	Other	22	45
469	ASPC.stem_like_progenitor	0.02	Nonsignificant	0.95	1.00	Other	300	842
470	EC.lymphatic.scavenger	0.02	Nonsignificant	1.00	0.40	Other	203	257
471	EC.capillary.migratory	0.02	Nonsignificant	0.90	0.87	Other	181	509
472	DC.cDC2.tolerogenic_regulatory	0.02	Nonsignificant	1.00	0.95	Other	44	4
473	GRNLSA.stress_metabolic	0.02	Nonsignificant	—	0.00	Other	1	2
474	ASPC.baseline	0.02	Nonsignificant	0.99	0.78	Other	363	170
475	EPI.ileal_goblet.stress_metallothionein	0.01	Nonsignificant	—	0.00	Other	4	11
476	T.CD8_Trm.cytotoxic	0.01	Nonsignificant	0.81	0.88	Other	165	85
477	T.CD4_cytotoxic.baseline	0.01	Nonsignificant	0.29	1.45	Other	0	0
478	T.CD8_Tem.early_helper_like	0.01	Nonsignificant	0.53	1.06	Other	445	755
479	GRNLSA.cholesterol_mevalonate	0.01	Nonsignificant	0.93	0.41	Other	9	4
480	THYMO.DN_preTCR	0.01	Nonsignificant	1.00	0.66	Other	41	71
481	MAC.resident_cardiac.antigen_presenting	0.01	Nonsignificant	0.20	1.33	Other	52	27
482	NK.adaptive_classII_inhibitory	0.01	Nonsignificant	1.00	1.02	Other	880	154
483	NEU.EXC_IT.structural	0.01	Nonsignificant	1.00	0.92	Other	171	41
484	ASPC.remodeling	0.01	Nonsignificant	0.99	0.78	Other	106	354
485	T.MAIT.early_activation	0.01	Nonsignificant	0.20	1.28	Other	57	4
486	T.gamma_delta.cytotoxic_effector	0.01	Nonsignificant	0.72	1.07	Other	349	109
487	EPI.skin_interfollicular_spinous.stress_oxidative	0.01	Nonsignificant	—	0.26	Other	0	0
488	T.CD4_Th17.migratory	0.01	Nonsignificant	0.38	1.15	Other	13	23
489	DC.cDC2.adhesion_signaling	0.01	Nonsignificant	1.00	0.78	Other	35	9
490	T.gamma_delta.early_effector	0.01	Nonsignificant	0.72	1.02	Other	89	0
491	T.CD4_Trm.activated	0.01	Nonsignificant	1.00	0.68	Other	32	26
492	EC.venous.adipose_lipid	0.01	Nonsignificant	1.00	0.84	Other	254	476
493	T.CD8_Tem.baseline	0.01	Nonsignificant	0.53	1.08	Other	458	356
494	EC.capillary.stress	0.01	Nonsignificant	0.90	0.89	Other	44	36
495	EC.capillary.postcap_venule	0.01	Nonsignificant	0.90	0.79	Other	355	261
496	ASPC.activated	0.01	Nonsignificant	0.99	0.73	Other	164	162
497	MAC.LAM.lipid_opsonization	0.01	Nonsignificant	0.71	1.21	Other	45	14
498	EC.capillary.angiogenic_tip	0.01	Nonsignificant	0.90	0.73	Other	186	218
499	EPI.alveolar_type_2.baseline_surfactant	0.01	Nonsignificant	0.07	1.45	Other	64	9
500	NK.adaptive_biosynthetic_primed	0.01	Nonsignificant	1.00	0.96	Other	244	405
501	THYMO.SP_CD8_naive	0.01	Nonsignificant	1.00	0.16	Other	297	177
502	HPC.MEP	0.01	Nonsignificant	0.51	1.17	Other	599	1,195
503	T.CD4_Tfh.effector_migratory	0.01	Nonsignificant	1.00	0.24	Other	122	57
504	EPI.ectocervical_granular.immune_interact	9.94e-03	Nonsignificant	—	0.00	Other	0	0
505	NEU.EXC_IT.guidance	9.86e-03	Nonsignificant	1.00	0.53	Other	274	63
506	MAC.resident_iron.heme_recycling	9.75e-03	Nonsignificant	—	0.00	Other	30	37
507	MONO.CD16.platelet_bound	9.68e-03	Nonsignificant	0.16	1.43	Other	372	508
508	T.CD4_naive.Treg_like	9.66e-03	Nonsignificant	0.67	1.21	Other	121	72
509	T.CD4_Tcm.Th2_like	9.61e-03	Nonsignificant	0.88	1.05	Other	23	55
510	ADIPO.inflammatory	9.45e-03	Nonsignificant	—	0.97	Other	0	0
511	T.CD8_naive.lipid_synthesis	9.31e-03	Nonsignificant	0.32	1.31	Other	6	4
512	HPC.GMP_granulocytic	9.30e-03	Nonsignificant	—	0.13	Other	3	3
513	EPI.pancreatic_acinar.baseline	9.13e-03	Nonsignificant	1.00	0.89	Other	274	163
514	EPI.renal_thick_ascending_limb.canonical_salt_transporter	9.06e-03	Nonsignificant	0.97	0.69	Other	322	317
515	T.CD4_Tcm.synapse_dynamics	9.01e-03	Nonsignificant	0.88	1.13	Other	15	10
516	EPI.colonocyte.goblet_interface	8.93e-03	Nonsignificant	—	0.00	Other	11	21
517	DC.cDC2.pro_inflammatory	8.91e-03	Nonsignificant	1.00	0.88	Other	3	5
518	PC.IgG_systemic.stress	8.78e-03	Nonsignificant	—	0.00	Other	1	5
519	T.CD4_Tcm.imprinted_splicing	8.74e-03	Nonsignificant	0.88	1.09	Other	6	17
520	MEL.stress_glucocorticoid	8.73e-03	Nonsignificant	1.00	0.58	Other	11	34
521	B.naive.proteostasis	8.56e-03	Nonsignificant	0.99	0.47	Other	49	69
522	T.CD4_naive.neddylation_mitoprot	8.52e-03	Nonsignificant	0.45	1.15	Other	93	56
523	EC.arterial.inflammatory	8.48e-03	Nonsignificant	1.00	0.17	Other	63	50
524	T.CD4_Tcm.tissue_homing	8.38e-03	Nonsignificant	0.91	0.92	Other	78	46
525	T.CD4_Tcm.crosstalk_myeloid	7.93e-03	Nonsignificant	0.88	0.99	Other	5	4
526	EPI.lung_multiciliated.stress	7.79e-03	Nonsignificant	—	0.00	Other	67	165
527	T.CD8_Tcm.baseline	7.77e-03	Nonsignificant	0.22	1.14	Other	90	89
528	EPI.salivary_serous_acinar.seromucous_like	7.47e-03	Nonsignificant	—	0.00	Other	0	0
529	MEL.mature_oxidative_traffic	7.41e-03	Nonsignificant	1.00	0.11	Other	247	285
530	EPI.cervical_suprabasal.secretory_vesicle	7.39e-03	Nonsignificant	—	0.00	Other	0	0
531	NK.adaptive_axis_baseline	7.25e-03	Nonsignificant	1.00	0.87	Other	1,008	153
532	EPI.lung_club_secretory.canonical_surfactant	7.23e-03	Nonsignificant	—	0.00	Other	74	104
533	ILC2.quiescent	7.19e-03	Nonsignificant	—	0.00	Other	0	0
534	T.CD4_Trm.stress_adaptive	6.95e-03	Nonsignificant	1.00	0.51	Other	8	22
535	T.CD4_naive.gut_prone	6.72e-03	Nonsignificant	0.68	1.12	Other	35	70
536	EC.venous.activated	6.68e-03	Nonsignificant	1.00	0.56	Other	247	752
537	T.CD4_Trm.cytotoxic_effector	6.61e-03	Nonsignificant	1.00	0.45	Other	118	77
538	T.CD4_Tcm.baseline	6.58e-03	Nonsignificant	0.88	1.00	Other	61	31
539	T.CD4_Tcm.DC_interact	6.40e-03	Nonsignificant	0.88	0.99	Other	72	32
540	EC.venous.remodeling_stalk	6.20e-03	Nonsignificant	1.00	0.41	Other	559	566
541	EPI.skin_interfollicular_spinous.inflammatory	6.00e-03	Nonsignificant	—	0.00	Other	0	0
542	T.CD4_naive.mature	5.86e-03	Nonsignificant	0.67	1.05	Other	211	100
543	EPI.alveolar_type_2.injury_primed	5.77e-03	Nonsignificant	0.98	0.93	Other	434	245
544	MAC.resident_repair.stress_iron	5.67e-03	Nonsignificant	0.18	1.41	Other	48	97
545	EPI.thymic_medullary.hormone_xeno_barrier	5.62e-03	Nonsignificant	—	0.66	Other	0	8
546	T.CD8_Tcm.effector_bias	5.56e-03	Nonsignificant	0.77	0.91	Other	199	329
547	MONO.CD14.inflammatory	5.50e-03	Nonsignificant	0.76	1.20	Other	92	134
548	NK.cytokine_quiescent	5.41e-03	Nonsignificant	1.00	0.96	Other	623	1,062
549	MAC.LAM.anti_inflammatory	5.39e-03	Nonsignificant	0.71	1.05	Other	86	132
550	T.CD4_naive.proteostasis_mitoprot	5.35e-03	Nonsignificant	0.67	1.14	Other	15	37
551	T.CD8_Tem.signaling_turnover	5.29e-03	Nonsignificant	0.95	0.58	Other	425	683
552	MAC.MDM.APC_dendritic	5.22e-03	Nonsignificant	0.79	1.17	Other	48	15
553	T.CD4_Tcm.stress	5.22e-03	Nonsignificant	0.88	1.11	Other	5	11
554	MAC.resident_cardiac.phagocytic_homeostasis	5.20e-03	Nonsignificant	0.91	0.77	Other	564	1,221
555	T.CD4_Tcm.retro_ZNF117	5.15e-03	Nonsignificant	0.91	0.93	Other	5	9
556	MAC.resident_repair.ECM_stromal_crosstalk	5.14e-03	Nonsignificant	0.20	1.23	Other	95	158
557	EPI.pancreatic_acinar.inflammatory_regenerative	5.11e-03	Nonsignificant	1.00	0.79	Other	25	113
558	GRNLSA.angiocrine_mechanosensory	4.93e-03	Nonsignificant	—	0.00	Other	0	0
559	T.CD8_Tem.motility_primed	4.92e-03	Nonsignificant	0.95	0.67	Other	269	4
560	EPI.skin_sweat_duct_keratinocyte.barrier	4.82e-03	Nonsignificant	—	0.00	Other	0	0
561	T.gamma_delta.central_memory	4.65e-03	Nonsignificant	0.92	0.85	Other	460	919
562	T.CD4_Tcm.effector_like	4.62e-03	Nonsignificant	0.91	0.91	Other	293	533
563	T.CD8_Tcm.gut_homing	4.56e-03	Nonsignificant	0.22	1.16	Other	380	112
564	NK.cytokine_lung_immediate_early	4.47e-03	Nonsignificant	1.00	0.94	Other	424	274
565	MAC.resident_repair.chemokine_angiocrine	4.47e-03	Nonsignificant	0.51	1.09	Other	87	138
566	NK.cytokine_tissue_activation	4.23e-03	Nonsignificant	1.00	0.77	Other	267	450
567	NK.adaptive_HLAE_tuned	4.17e-03	Nonsignificant	1.00	0.75	Other	1,124	189
568	ADIPO.immature	4.13e-03	Nonsignificant	—	0.44	Other	24	40
569	NK.cytokine_axis_baseline	4.10e-03	Nonsignificant	1.00	0.99	Other	1,172	116
570	EPI.skin_hair_follicle_companion.activated_migratory	4.06e-03	Nonsignificant	—	0.00	Other	0	0
571	T.CD8_naive.nfkb_related	4.02e-03	Nonsignificant	0.59	1.19	Other	1	0
572	SCHWN.axon_contact_cardiac	3.99e-03	Nonsignificant	0.98	0.27	Other	18	63
573	T.CD4_naive.purinergic	3.87e-03	Nonsignificant	0.67	1.11	Other	49	1
574	EPI.colonocyte.junction_remodeling	3.65e-03	Nonsignificant	1.00	0.00	Other	218	305
575	EPI.renal_distal_tubule.immune_modulatory	3.63e-03	Nonsignificant	—	0.00	Other	0	0
576	T.CD4_naive.homeostatic	3.62e-03	Nonsignificant	0.81	0.97	Other	215	108
577	T.CD4_naive.neddylation	3.60e-03	Nonsignificant	0.67	1.05	Other	104	222
578	T.CD4_naive.resist_bystander	3.52e-03	Nonsignificant	0.68	1.05	Other	40	25
579	NK.cytokine_repair_primed	3.45e-03	Nonsignificant	0.71	1.14	Other	266	11
580	T.CD8_naive.vesicle_secretory	3.41e-03	Nonsignificant	0.32	1.25	Other	42	0
581	EC.liver_sinusoidal.secretory_lipoprotein	3.33e-03	Nonsignificant	0.90	0.63	Other	120	70
582	T.CD4_naive.mature_mitoprot	3.31e-03	Nonsignificant	0.81	0.95	Other	212	476
583	EPI.alveolar_type_2.stress_response	3.30e-03	Nonsignificant	0.98	0.51	Other	675	1,562
584	T.CD4_Tcm.Tfh_like	3.30e-03	Nonsignificant	0.88	0.98	Other	102	214
585	MAC.resident_cardiac.inflammatory_reparative	3.21e-03	Nonsignificant	0.91	0.80	Other	31	96
586	CM.sarcomere_actin_interface	3.03e-03	Nonsignificant	1.00	0.93	Other	450	78
587	ADIPO.thermogenic	2.84e-03	Nonsignificant	—	0.00	Other	0	0
588	EPI.skin_interfollicular_spinous.proliferative	2.83e-03	Nonsignificant	—	0.70	Other	0	0
589	EPI.thymic_medullary.stress_APC	2.79e-03	Nonsignificant	0.18	1.50	Other	2	4
590	DC.pDC.baseline	2.75e-03	Nonsignificant	0.57	1.37	Other	88	123
591	T.CD4_Tcm.migratory_cilium	2.70e-03	Nonsignificant	0.96	0.83	Other	5	10
592	NK.cytokine_vascular_patrolling	2.57e-03	Nonsignificant	0.38	1.12	Other	863	94
593	FIB.barrier_secretory.homeostasis	2.51e-03	Nonsignificant	—	0.00	Other	0	0
594	T.CD4_cytotoxic.terminal_effector	2.49e-03	Nonsignificant	0.97	0.85	Other	286	21
595	MONO.CD16.baseline	2.47e-03	Nonsignificant	0.42	1.18	Other	50	1
596	MAC.microglia_like.inflammatory_chemokine	2.37e-03	Nonsignificant	—	0.00	Other	20	32
597	T.CD4_naive.survival	2.34e-03	Nonsignificant	0.81	0.95	Other	12	17
598	DC.cDC2.migratory	2.33e-03	Nonsignificant	1.00	0.23	Other	185	39
599	B.germinal_center.LZ_selection	2.31e-03	Nonsignificant	—	1.13	Other	0	0
600	SKM.type_2_fast.oxidative_IIa	2.29e-03	Nonsignificant	0.72	0.90	Other	946	56
601	T.CD4_cytotoxic.activated	2.19e-03	Nonsignificant	0.82	1.02	Other	3	1
602	ADIPO.hypoxia_remodelling	2.18e-03	Nonsignificant	—	0.00	Other	29	105
603	T.CD4_Tcm.RNA_control	2.11e-03	Nonsignificant	0.96	0.82	Other	96	4
604	NK.cytokine_biosynthetic_primed	2.10e-03	Nonsignificant	1.00	0.79	Other	360	21
605	T.CD4_Th17.baseline	2.09e-03	Nonsignificant	0.91	0.79	Other	51	5
606	MONO.CD14.repair_M2_like	2.05e-03	Nonsignificant	0.85	1.00	Other	550	1,495
607	EPI.thymic_cortical.secretory_remodeling	2.00e-03	Nonsignificant	—	1.23	Other	4	1
608	SKM.type_2_fast.glycolytic_IIx_IIb	1.98e-03	Nonsignificant	0.72	0.98	Other	565	1,482
609	GRANU.neutrophil.antiviral_endotoxin	1.95e-03	Nonsignificant	—	0.64	Other	0	0
610	T.CD4_naive.survival_mitoprot	1.91e-03	Nonsignificant	0.81	0.94	Other	13	7
611	T.CD4_naive.proteostasis	1.88e-03	Nonsignificant	0.81	0.93	Other	14	9
612	MAC.MDM.LAM_like	1.85e-03	Nonsignificant	0.88	0.94	Other	12	14
613	T.CD4_naive.survival_neddylation	1.75e-03	Nonsignificant	0.81	0.88	Other	26	38
614	MAC.MDM.inflammatory_phagocytic	1.70e-03	Nonsignificant	0.88	0.95	Other	199	52
615	EPI.thymic_medullary.canonical_alarmin	1.69e-03	Nonsignificant	0.92	0.43	Other	8	17
616	EPI.thymic_medullary.proliferative_APC	1.67e-03	Nonsignificant	—	0.00	Other	0	0
617	HPC.MPP_IEG	1.65e-03	Nonsignificant	0.91	0.48	Other	45	46
618	EPI.pancreatic_acinar.adhesion_remodeling	1.52e-03	Nonsignificant	1.00	0.45	Other	210	784
619	MAC.LAM.lipid_phagocytosis	1.50e-03	Nonsignificant	0.71	0.97	Other	369	328
620	EPI.salivary_mucous_acinar.baseline	1.45e-03	Nonsignificant	—	—	Other	394	683
621	MONO.CD14.APC_like	1.43e-03	Nonsignificant	0.76	1.03	Other	1,686	2,493
622	GRANU.neutrophil.primed_degranulation	1.38e-03	Nonsignificant	—	0.00	Other	0	0
623	CM.mechano_activated	1.22e-03	Nonsignificant	1.00	0.85	Other	205	134
624	NK.adaptive_terminal_cytotoxic	1.19e-03	Nonsignificant	1.00	0.48	Other	485	802
625	CM.osmoprotection	1.19e-03	Nonsignificant	1.00	0.96	Other	34	57
626	T.MAIT.migratory	1.14e-03	Nonsignificant	0.81	1.14	Other	10	1
627	T.CD8_naive.splicing_enriched	1.11e-03	Nonsignificant	0.96	0.93	Other	120	16
628	MONO.CD14.baseline	1.10e-03	Nonsignificant	1.00	0.93	Other	2,268	76
629	DC.cDC2.monocyte_like	1.04e-03	Nonsignificant	1.00	0.04	Other	1,285	791
630	MONO.CD14.remodeling	1.02e-03	Nonsignificant	0.76	1.02	Other	2,373	295
631	DC.pDC.immature_metabolic	9.91e-04	Nonsignificant	0.57	1.17	Other	78	124
632	EPI.skin_interfollicular_spinous.upper_lipid	9.85e-04	Nonsignificant	—	0.27	Other	6	6
633	MAC.MDM.complement_resolving	9.64e-04	Nonsignificant	0.89	0.79	Other	440	860
634	MONO.CD16.patrolling	9.55e-04	Nonsignificant	0.84	0.96	Other	797	216
635	CM.inflammatory	9.46e-04	Nonsignificant	—	0.98	Other	0	0
636	MAC.resident_repair.lipid_phagocytic	9.23e-04	Nonsignificant	0.51	1.13	Other	228	604
637	MAC.resident_repair.antigen_presenting	9.18e-04	Nonsignificant	1.00	0.43	Other	244	113
638	T.CD8_naive.cytokine_dampened	9.02e-04	Nonsignificant	0.96	0.99	Other	71	4
639	B.germinal_center.LZ_survival	8.88e-04	Nonsignificant	—	0.37	Other	0	0
640	T.CD4_Tcm.secretory	8.50e-04	Nonsignificant	0.96	0.63	Other	20	11
641	T.CD4_cytotoxic.NK_adapted	8.46e-04	Nonsignificant	0.98	0.39	Other	82	33
642	EPI.skin_sweat_duct_keratinocyte.repair	8.00e-04	Nonsignificant	—	0.00	Other	0	0
643	B.germinal_center.LZ_memory_precursor	7.99e-04	Nonsignificant	—	0.00	Other	0	0
644	CM.oxidative_phospho	7.61e-04	Nonsignificant	1.00	0.97	Other	266	792
645	CM.translation_boost_RPL	6.87e-04	Nonsignificant	1.00	0.89	Other	129	1
646	DC.pDC.poised_migratory	6.44e-04	Nonsignificant	0.57	0.91	Other	54	95
647	EC.liver_sinusoidal.stress	6.11e-04	Nonsignificant	—	0.00	Other	413	158
648	T.CD8_naive.effector_transition	5.41e-04	Nonsignificant	0.96	0.81	Other	35	62
649	MONO.CD16.hepatic_mac_like	5.39e-04	Nonsignificant	0.84	0.96	Other	803	117
650	T.MAIT.MAPK_brake	5.29e-04	Nonsignificant	0.81	0.98	Other	44	66
651	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	5.17e-04	Nonsignificant	—	0.00	Other	0	0
652	MONO.CD16.inflammatory	5.09e-04	Nonsignificant	0.86	0.87	Other	1,640	168
653	EPI.lung_club_secretory.ciliogenesis_primed	5.07e-04	Nonsignificant	—	0.00	Other	0	0
654	CM.mito_proteostasis	4.88e-04	Nonsignificant	1.00	0.90	Other	329	29
655	EPI.skin_interfollicular_spinous.early_differentiation	4.57e-04	Nonsignificant	0.99	0.51	Other	89	19
656	EPI.pancreatic_acinar.quiet_dedifferentiation	4.53e-04	Nonsignificant	1.00	0.00	Other	142	171
657	MAC.kupffer.metabolic	3.94e-04	Nonsignificant	—	0.00	Other	25	36
658	T.CD8_naive.baseline	3.79e-04	Nonsignificant	1.00	0.70	Other	142	2
659	GRANU.neutrophil.tissue_patrolling	3.63e-04	Nonsignificant	—	0.00	Other	0	0
660	T.CD8_naive.innate_like	3.45e-04	Nonsignificant	0.96	0.81	Other	10	1
661	MAC.LAM.perivascular_angiocrine	2.89e-04	Nonsignificant	—	0.00	Other	53	138
662	MONO.CD14.cord_tolerance	2.64e-04	Nonsignificant	1.00	0.84	Other	864	753
663	SKM.type_1_slow.oxidative	2.54e-04	Nonsignificant	0.71	1.16	Other	802	251
664	MAC.LAM.antimicrobial	2.48e-04	Nonsignificant	1.00	0.29	Other	389	93
665	EC.liver_sinusoidal.remodeling_lipotoxicity	2.48e-04	Nonsignificant	—	0.00	Other	90	58
666	T.MAIT.quiescent	2.47e-04	Nonsignificant	0.81	1.04	Other	100	5
667	OLG.reactive_repair	2.42e-04	Nonsignificant	1.00	0.01	Other	385	385
668	EPI.skin_interfollicular_spinous.baseline	2.31e-04	Nonsignificant	0.99	0.53	Other	35	3
669	SKM.type_1_slow.contractile	1.76e-04	Nonsignificant	0.71	0.98	Other	596	8
670	T.MAIT.cytotoxic	1.76e-04	Nonsignificant	0.81	0.91	Other	52	15
671	B.germinal_center.DZ_S_phase	1.71e-04	Nonsignificant	—	0.00	Other	0	0
672	B.germinal_center.DZ_M_phase	1.44e-04	Nonsignificant	—	0.00	Other	0	0
673	CM.anti_inflammatory	1.27e-04	Nonsignificant	1.00	0.61	Other	424	1,503
674	MAC.alveolar.stress_metabolic	1.07e-04	Nonsignificant	0.50	1.35	Other	116	148
675	SKM.type_1_slow.glycolytic	9.72e-05	Nonsignificant	0.71	0.83	Other	362	647
676	CM.translation_boost_RPS	6.96e-05	Nonsignificant	1.00	0.66	Other	69	16
677	EPI.skin_interfollicular_spinous.stress_UPR	5.64e-05	Nonsignificant	—	0.00	Other	0	0
678	T.MAIT.vesicle	4.69e-05	Nonsignificant	0.93	0.57	Other	37	65
679	MAC.alveolar.lipid_autophagy	4.23e-05	Nonsignificant	—	0.98	Other	35	44
680	MAC.alveolar.capillary_interacting	4.14e-05	Nonsignificant	0.50	1.27	Other	113	181
681	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.95e-05	Nonsignificant	—	0.00	Other	0	0
682	HPC.MPP_activated	1.32e-05	Nonsignificant	—	0.00	Other	0	0
683	MAC.alveolar.inflammatory	1.09e-05	Nonsignificant	0.96	0.73	Other	208	312
684	MAC.alveolar.biosynthetic_sterol_heme	6.47e-06	Nonsignificant	0.96	0.44	Other	347	40
685	MAC.alveolar.scavenging_endocytic	6.04e-06	Nonsignificant	—	0.00	Other	140	283
686	T.MAIT.stress	4.58e-06	Nonsignificant	—	0.00	Other	0	0
687	EPI.thymic_cortical.Notch_interface	3.45e-08	Nonsignificant	—	0.00	Other	82	137
688	EPI.thymic_cortical.baseline	3.15e-08	Nonsignificant	0.95	0.27	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

26 unique genes. Showing 1–26. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ENSG00000297913	01-High	0.67	11.98	G1	C1	—	—	—	11	15
ENSG00000297934	01-High	0.64	8.38	G1	C1	—	—	—	11	15
DUSP23	01-High	0.64	11.63	G1	C1	EPI.renal_thick_ascending_limb.remodeling (L2)	—	15 cells — complete matches	13	16
CRP	01-High	0.61	9.30	G1	C1	HEP.acute_phase (L1S)	HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) EPI.hepatic_ductular_cholangiocyte (Tier: relevant) HEP.acute_phase.complement_antiviral (Tier: relevant) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant) HEP.acute_phase.stress_secretory (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant)	25 cells — complete matches	10	13
ENSG00000288775	01-High	0.60	10.00	G1	C1	—	—	—	11	14
APCS	01-High	0.46	5.40	G1	C1	—	—	—	10	16
ACKR1	01-High	0.45	5.49	G1	C1	EC.heart_remodeling (L1S), EC.venous (L1S), EC.arterial.arteriole_interface (L2), EC.capillary.postcap_venule (L2), EC.venous.baseline (L2)	—	18 cells — complete matches	20	35
ENSG00000231100	01-High	0.44	4.19	G1	C1	—	—	—	10	14
LINC02819	01-High	0.44	3.83	G1	C1	—	—	—	10	14
FCRL6	01-High	0.43	3.18	G1	C1	T.CD4_transitional.primed_cytotoxic (L2), T.CD8_Tcm.NK_like (L2), T.CD8_transitional.effector_primed (L2)	—	68 cells — complete matches	13	16
AIM2	01-High	0.43	5.50	G1	C1	B.memory.baseline (L2)	EPI.endocervical_secretory.squamous_barrier (Tier: relevant)	77 cells — complete matches	13	30
FCER1A	01-High	0.41	4.07	G1	C1	dendritic_cell (L1), DC.cDC2 (L1S), DC.cDC2.tolerogenic_regulatory (L2), HPC.MEP (L2), MAC.MDM.APC_dendritic (L2), MAC.resident_repair.antigen_presenting (L2)	—	56 cells — complete matches	34	50
ENSG00000289484	01-High	0.40	3.65	G1	C1	—	—	—	11	16
ENSG00000228560	01-High	0.39	2.78	G1	C1	—	—	—	9	14
ENSG00000272668	01-High	0.39	2.58	G1	C1	—	—	—	10	14
SNHG28	01-High	0.38	2.59	G1	C1	—	—	—	11	14
CFAP45	01-High	0.37	1.88	G1	C1	EPI.lung_multiciliated.baseline (L2)	—	30 cells — complete matches	12	14
SLAMF8	01-High	0.37	2.35	G1	C1	—	—	66 cells — complete matches	12	16
ENSG00000256029	01-High	0.37	2.18	G1	C1	—	—	—	11	14
PYHIN1	01-High	0.36	3.24	G1	C1	—	—	103 cells — complete matches	14	29
FCGR2B	01-High	0.36	1.58	G1	C1	EC.liver_sinusoidal (L1S), DC.cDC2.tolerogenic_regulatory (L2), HEP.canalicular_transport.secretory_ERAD_UPR (L2), MAC.alveolar.capillary_interacting (L2), MAC.resident_iron.APC_iron_sensing (L2)	—	86 cells — complete matches	209	293
LINC01133	01-High	0.35	2.43	G1	C1	—	EPI.endocervical_secretory.squamous_barrier (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.barrier_mucin (Tier: relevant) EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit (Tier: relevant)	49 cells — complete matches	6	11
IGSF9	01-High	0.35	2.32	G1	C1	—	—	14 cells — complete matches	11	14
ENSG00000283360	01-High	0.34	2.01	G1	C1	—	—	—	194	263
HLA-DQB1	02-Medium	0.41	5.04	G2	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	EPI.hepatic_ductular_cholangiocyte.ion_transport (Tier: relevant)	133 cells — complete matches	703	1,314
ENSG00000303029	02-Medium	0.35	5.09	G2	C2	—	—	—	234	380

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.