Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000030 · All tissues

Acute renal failure: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Kidney failure, acute

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	natural_killer_cell	15.51	Significant	1.85e-48	1.34	Specific	1,204	2,052
2	T_cell	12.18	Significant	3.30e-49	1.46	Specific	470	959
3	innate_lymphoid_cell_2	6.45	Significant	1.00	0.89	Other	3	8
4	haematopoietic_progenitor_cell	5.37	Nominal	1.00	0.91	Other	262	502
5	endothelial_cell	5.17	Nominal	1.00	0.97	Other	373	974
6	adipose_stem_and_progenitor_cell	5.03	Nominal	1.00	0.98	Other	327	954
7	dendritic_cell	3.92	Nominal	1.00	0.92	Other	496	724
8	B_cell	1.91	Nonsignificant	1.00	0.77	Other	356	694
9	macrophage	1.42	Nonsignificant	1.00	0.78	Other	813	1,732
10	thymocyte	1.26	Nonsignificant	1.00	0.72	Other	168	512
11	epithelial_cell	1.15	Nonsignificant	1.00	0.68	Other	24	47
12	fibroblast	0.86	Nonsignificant	1.00	0.73	Other	184	826
13	granulocyte	0.74	Nonsignificant	1.00	0.76	Other	5	6
14	smooth_muscle_cell	0.59	Nonsignificant	1.00	0.65	Other	27	139
15	granulosa_cell	0.57	Nonsignificant	1.00	0.57	Other	293	670
16	pericyte	0.57	Nonsignificant	1.00	0.71	Other	128	517
17	hepatocyte	0.41	Nonsignificant	1.00	0.56	Other	1,515	3,822
18	astrocyte	0.38	Nonsignificant	1.00	0.59	Other	256	1,203
19	melanocyte	0.29	Nonsignificant	1.00	0.56	Other	97	309
20	monocyte	0.26	Nonsignificant	1.00	0.48	Other	2,176	3,871
21	muscle_stem_cell	0.23	Nonsignificant	1.00	0.55	Other	7	27
22	oligodendrocyte	0.13	Nonsignificant	1.00	0.42	Other	385	1,507
23	plasma_cell	0.10	Nonsignificant	1.00	0.41	Other	17	24
24	adipocyte	0.08	Nonsignificant	1.00	0.44	Other	33	111
25	induced_pluripotent_stem_cell	0.08	Nonsignificant	1.00	0.39	Other	0	0
26	schwann_cell	0.02	Nonsignificant	1.00	0.29	Other	10	57
27	platelet	0.01	Nonsignificant	—	0.00	Other	85	104
28	microglia	7.97e-03	Nonsignificant	1.00	0.29	Other	61	129
29	mesothelial_cell	2.40e-03	Nonsignificant	1.00	0.27	Other	6	36
30	oligodendrocyte_precursor_cell	9.91e-04	Nonsignificant	1.00	0.26	Other	461	1,454
31	neuron	8.80e-04	Nonsignificant	1.00	0.31	Other	330	1,328
32	chondrocyte	7.89e-04	Nonsignificant	1.00	0.24	Other	548	1,069
33	cardiomyocyte	7.41e-04	Nonsignificant	1.00	0.27	Other	533	2,045
34	skeletal_muscle_cell	2.53e-06	Nonsignificant	1.00	0.22	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	NK.natural_killer_cell	15.51	Significant	—	—	Specific	1,204	2,045
2	T.CD8_Tem	15.07	Significant	1.32e-18	2.45	Specific	1,083	1,857
3	T.CD4_cytotoxic	14.87	Significant	4.48e-04	1.94	Specific	855	1,493
4	T.CD4_naive	13.61	Significant	6.87e-08	1.65	Specific	399	866
5	T.CD8_Trm	13.29	Significant	0.02	1.51	Specific	211	346
6	T.CD8_Tcm	12.13	Significant	1.00	0.92	Relevant	460	926
7	T.CD8_transitional	11.65	Significant	1.00	0.87	Specific	497	932
8	T.CD8_naive	11.49	Significant	1.00	0.75	Specific	317	708
9	T.MAIT	11.32	Significant	1.00	0.98	Specific	469	855
10	T.CD4_Tcm	11.30	Significant	1.00	0.51	Specific	494	988
11	T.gamma_delta	11.14	Significant	1.00	0.93	Specific	588	1,078
12	T.CD4_Th17	11.08	Significant	1.00	1.08	Relevant	421	794
13	T.CD4_Tem	10.99	Significant	1.00	0.66	Specific	365	697
14	T.CD4_Tfh	10.64	Significant	1.00	0.67	—	47	45
15	T.CD4_transitional	10.16	Significant	1.00	0.30	Relevant	48	110
16	T.CD4_Trm	10.01	Significant	1.00	0.24	Relevant	176	363
17	EC.capillary	9.22	Significant	2.96e-13	1.44	Specific	514	1,635
18	EPI.renal_proximal_tubule	7.67	Significant	3.86e-05	1.52	Specific	525	806
19	EPI.intrahepatic_cholangiocyte_defense	6.98	Significant	—	1.94	Relevant	8	13
20	T.CD4_Th2	6.98	Significant	—	0.00	Relevant	1	2
21	EPI.skin_interfollicular_spinous	6.91	Significant	2.11e-08	1.55	Specific	260	563
22	ILC2.innate_lymphoid_cell_2	6.45	Significant	—	—	Other	2	0
23	EPI.tracheal_basal	6.33	Significant	1.51e-04	1.48	Specific	398	1,120
24	EC.venous	5.90	Significant	1.00	1.02	Other	516	1,387
25	HPC.haematopoietic_progenitor_cell	5.37	Nominal	—	—	Other	211	370
26	ASPC.adipose_stem_and_progenitor_cell	5.03	Nominal	—	—	Other	324	930
27	DC.cDC2	4.69	Nominal	1.86e-05	2.11	Other	1,189	1,793
28	DC.cDC1	4.36	Nominal	0.80	0.95	Other	55	112
29	T.CD4_Treg	4.05	Nominal	1.00	0.02	Other	244	511
30	EPI.intrahepatic_cholangiocyte_transport	3.82	Nominal	—	1.25	Other	12	42
31	FIB.barrier_secretory	3.62	Nominal	0.64	1.16	Other	81	228
32	FIB.transitioning	3.43	Nominal	0.31	1.18	Other	172	497
33	EPI.bile_duct_cholangiocyte	3.26	Nominal	0.29	1.37	Other	37	60
34	MAC.alveolar	3.22	Nominal	0.02	1.29	Other	1,432	3,122
35	EPI.tracheal_suprabasal	3.22	Nominal	0.81	1.26	Other	29	56
36	EC.arterial	3.19	Nominal	1.00	0.82	Other	356	885
37	EPI.skin_keratinocyte_proliferating	2.86	Nonsignificant	0.94	1.18	Other	47	76
38	EPI.pancreatic_ductal_bicarbonate	2.66	Nonsignificant	0.02	1.24	Other	131	548
39	MAC.LAM	2.49	Nonsignificant	1.27e-04	1.29	Other	914	2,064
40	DC.mig	2.42	Nonsignificant	—	0.00	Other	89	156
41	B.naive	2.27	Nonsignificant	1.56e-05	1.46	Other	307	595
42	FIB.interstitial	2.09	Nonsignificant	1.28e-13	1.30	Other	288	940
43	MAC.proliferating	1.84	Nonsignificant	0.87	1.07	Other	87	253
44	EPI.hepatic_ductular_cholangiocyte	1.71	Nonsignificant	1.00	0.96	Other	83	243
45	EPI.salivary_mucous_acinar	1.63	Nonsignificant	0.11	1.20	Other	639	1,189
46	MAC.MDM	1.59	Nonsignificant	0.87	1.02	Other	623	986
47	B.memory	1.57	Nonsignificant	1.00	0.56	Other	442	882
48	EPI.salivary_serous_acinar	1.56	Nonsignificant	0.03	1.17	Other	233	531
49	EPI.skin_follicular_keratinizing	1.45	Nonsignificant	1.00	1.04	Other	30	81
50	EPI.extrahepatic_cholangiocyte	1.42	Nonsignificant	—	0.60	Other	37	71
51	EPI.pancreatic_ductal_perivascular	1.37	Nonsignificant	1.00	0.92	Other	4	30
52	FIB.tracheal_subepithelial	1.35	Nonsignificant	—	0.79	Other	0	0
53	FIB.reticular	1.33	Nonsignificant	1.00	0.95	Other	19	87
54	EPI.skin_keratinocyte_basal	1.28	Nonsignificant	—	0.63	Other	13	26
55	THYMO.thymocyte	1.26	Nonsignificant	—	—	Other	163	495
56	GRANU.MAST	1.17	Nonsignificant	9.43e-04	1.76	Other	5	6
57	EC.lymphatic	1.07	Nonsignificant	1.00	0.61	Other	630	998
58	EPI.skin_sweat_duct_keratinocyte	0.97	Nonsignificant	1.00	0.81	Other	146	301
59	EPI.salivary_duct_excretory	0.88	Nonsignificant	1.00	0.87	Other	85	180
60	EPI.pancreatic_ductal_progenitor	0.83	Nonsignificant	1.00	0.92	Other	234	873
61	EPI.skin_keratinocyte_progenitor	0.83	Nonsignificant	—	0.22	Other	0	3
62	B.age_associated	0.83	Nonsignificant	1.00	0.14	Other	207	350
63	HEP.periportal_metabolic	0.80	Nonsignificant	2.25e-23	1.59	Other	1,750	4,427
64	MAC.resident_iron	0.75	Nonsignificant	1.00	0.69	Other	16	21
65	MAC.microglia_like	0.73	Nonsignificant	1.00	0.78	Other	124	179
66	EPI.salivary_duct_ion_transport	0.72	Nonsignificant	1.00	0.97	Other	5	11
67	EPI.esophageal_basal	0.69	Nonsignificant	1.00	0.79	Other	4	10
68	B.germinal_center	0.61	Nonsignificant	1.00	0.06	Other	233	655
69	SMC.smooth_muscle_cell	0.59	Nonsignificant	—	—	Other	20	101
70	DC.pDC	0.59	Nonsignificant	1.00	0.00	Other	496	1,028
71	GRNLSA.granulosa_cell	0.57	Nonsignificant	—	—	Other	257	0
72	PERI.pericyte	0.57	Nonsignificant	—	—	Other	117	0
73	EPI.renal_immature_ureteric_bud	0.57	Nonsignificant	1.00	0.68	Other	217	569
74	EPI.alveolar_type_1	0.57	Nonsignificant	1.00	0.90	Other	26	101
75	EPI.salivary_intercalated_defense	0.55	Nonsignificant	1.00	0.69	Other	81	161
76	EPI.pancreatic_ductal_mucinous	0.53	Nonsignificant	1.00	0.70	Other	219	430
77	EPI.skin_hair_follicle_bulge	0.52	Nonsignificant	1.00	0.76	Other	51	178
78	EPI.renal_principal_cell	0.52	Nonsignificant	1.00	0.72	Other	207	403
79	EPI.ileal_enterocyte_crypt	0.45	Nonsignificant	1.00	0.71	Other	67	113
80	EPI.skin_sebaceous_duct_luminal	0.42	Nonsignificant	1.00	0.63	Other	100	249
81	ASTRO.astrocyte	0.38	Nonsignificant	—	—	Other	228	1,111
82	EPI.tracheal_submucosal_gland	0.37	Nonsignificant	—	0.04	Other	0	0
83	FIB.perivascular_interface	0.37	Nonsignificant	1.00	0.82	Other	0	0
84	HEP.acute_phase	0.37	Nonsignificant	0.24	1.09	Other	1,441	3,641
85	EPI.gastric_foveolar	0.36	Nonsignificant	—	0.05	Other	0	0
86	MAC.resident_repair	0.36	Nonsignificant	1.00	0.58	Other	796	1,426
87	EPI.esophageal_suprabasal	0.36	Nonsignificant	1.00	0.67	Other	158	404
88	EPI.skin_appendage_keratinocyte	0.33	Nonsignificant	1.00	0.55	Other	87	222
89	EPI.renal_intercalated_cell_type_B	0.33	Nonsignificant	—	0.00	Other	6	7
90	EPI.colonic_enteroendocrine	0.32	Nonsignificant	—	0.00	Other	1	1
91	FIB.barrier_purinergic	0.32	Nonsignificant	—	0.41	Other	1	3
92	EPI.pancreatic_islet	0.32	Nonsignificant	1.00	0.68	Other	52	132
93	MONO.CD16	0.30	Nonsignificant	0.84	0.99	Other	1,304	1,835
94	EPI.renal_thick_ascending_limb	0.30	Nonsignificant	1.00	0.62	Other	453	1,153
95	MEL.melanocyte	0.29	Nonsignificant	—	—	Other	79	242
96	MONO.CD14	0.25	Nonsignificant	0.84	0.96	Other	2,294	4,139
97	MUSC.muscle_stem_cell	0.23	Nonsignificant	—	—	Other	4	18
98	EPI.renal_intercalated_cell_type_A	0.22	Nonsignificant	1.00	0.87	Other	67	142
99	EPI.colonocyte	0.18	Nonsignificant	1.00	0.52	Other	294	815
100	EPI.lung_club_secretory	0.16	Nonsignificant	1.00	0.52	Other	5	14
101	FIB.hepatic_stellate_cell	0.15	Nonsignificant	—	0.19	Other	64	252
102	FIB.lung_alveolar	0.13	Nonsignificant	—	0.13	Other	6	15
103	EPI.salivary_myoepithelial	0.13	Nonsignificant	1.00	0.85	Other	191	714
104	OLG.oligodendrocyte	0.13	Nonsignificant	—	—	Other	384	1,397
105	FIB.neurolectin_mucosa	0.12	Nonsignificant	1.00	0.70	Other	133	394
106	FIB.suburothelial	0.11	Nonsignificant	1.00	0.73	Other	122	432
107	PC.IgA_muocsal	0.10	Nonsignificant	0.59	0.96	Other	18	31
108	FIB.skin_neurosecretory	0.10	Nonsignificant	—	0.07	Other	0	0
109	EC.heart_remodeling	0.09	Nonsignificant	1.00	0.06	Other	569	1,594
110	PC.IgG_systemic	0.08	Nonsignificant	0.59	0.95	Other	41	60
111	ADIPO.adipocyte	0.08	Nonsignificant	—	—	Other	20	62
112	IPSC.induced_pluripotent_stem_cell	0.08	Nonsignificant	—	—	Other	0	0
113	EPI.alveolar_type_2	0.07	Nonsignificant	1.00	0.33	Other	813	1,853
114	EPI.ectocervical_granular	0.07	Nonsignificant	—	0.00	Other	11	23
115	EC.liver_sinusoidal	0.06	Nonsignificant	1.00	0.15	Other	1,083	1,925
116	HEP.pericentral_lipoprotein	0.06	Nonsignificant	—	0.00	Other	0	0
117	EPI.ileal_enterocyte_absorptive	0.05	Nonsignificant	1.00	0.99	Other	118	338
118	EPI.colonic_tuft	0.05	Nonsignificant	—	0.00	Other	7	24
119	HEP.canalicular_transport	0.04	Nonsignificant	1.00	0.14	Other	1,290	3,434
120	EPI.ileal_goblet	0.04	Nonsignificant	1.00	0.22	Other	181	432
121	FIB.skin_sheath	0.04	Nonsignificant	1.00	0.64	Other	49	118
122	EPI.skin_hair_follicle_companion	0.04	Nonsignificant	—	0.00	Other	8	12
123	EPI.thymic_medullary	0.04	Nonsignificant	1.00	0.23	Other	26	133
124	EPI.pancreatic_acinar	0.03	Nonsignificant	1.00	0.12	Other	429	1,475
125	FIB.skin_tenogenic	0.03	Nonsignificant	—	0.00	Other	108	227
126	EPI.cervical_suprabasal	0.02	Nonsignificant	—	0.00	Other	14	50
127	MAC.kupffer	0.02	Nonsignificant	1.00	0.42	Other	189	530
128	FIB.skin_papillary	0.02	Nonsignificant	—	0.00	Other	0	0
129	SCHWN.schwann_cell	0.02	Nonsignificant	—	—	Other	7	33
130	NEU.EXC_SYT2	0.02	Nonsignificant	—	0.21	Other	40	77
131	PLAT.platelet	0.01	Nonsignificant	—	0.00	Other	38	53
132	EPI.ileal_bile_transport	0.01	Nonsignificant	1.00	0.13	Other	61	93
133	EPI.renal_distal_tubule	9.47e-03	Nonsignificant	1.00	0.33	Other	133	361
134	MG.microglia	7.97e-03	Nonsignificant	—	—	Other	49	0
135	MESO.mesothelial_cell	2.40e-03	Nonsignificant	—	—	Other	2	18
136	FIB.adventitial	2.14e-03	Nonsignificant	1.00	3.59e-03	Other	268	1,447
137	NEU.INH_VIP	1.22e-03	Nonsignificant	0.81	1.06	Other	241	366
138	OPC.oligodendrocyte_precursor_cell	9.91e-04	Nonsignificant	—	—	Other	413	1,269
139	CHOND.chondrocyte	7.89e-04	Nonsignificant	—	—	Other	519	730
140	NEU.EXC_IT	7.56e-04	Nonsignificant	5.20e-03	1.05	Other	411	192
141	CM.cardiomyocyte	7.41e-04	Nonsignificant	—	—	Other	524	2,032
142	GRANU.neutrophil	5.29e-04	Nonsignificant	1.00	0.00	Other	1,235	2,649
143	EPI.endocervical_secretory	3.85e-04	Nonsignificant	—	0.00	Other	0	0
144	MAC.resident_cardiac	1.18e-04	Nonsignificant	1.00	0.09	Other	485	1,074
145	NEU.INH_PVALB	6.61e-05	Nonsignificant	0.97	0.97	Other	193	183
146	EPI.thymic_cortical	7.87e-06	Nonsignificant	1.00	0.06	Other	442	824
147	NEU.EXC_NTNG1	4.71e-06	Nonsignificant	—	0.65	Other	0	0
148	NEU.INH_LAMP5	4.41e-06	Nonsignificant	0.97	0.80	Other	263	532
149	SKM.type_2_fast	4.40e-06	Nonsignificant	2.16e-18	1.06	Other	972	2,639
150	NEU.EXC_CT	9.97e-07	Nonsignificant	0.97	0.70	Other	362	384
151	EPI.lung_multiciliated	1.65e-07	Nonsignificant	1.00	0.02	Other	16	49
152	SKM.type_1_slow	4.66e-12	Nonsignificant	1.00	0.04	Other	923	2,478

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	T.CD4_naive.activated_stress	29.72	Significant	3.21e-07	2.87	—	339	429
2	NK.adaptive_classII_inhibitory	20.38	Significant	1.51e-09	3.31	—	880	154
3	NK.adaptive_terminal_cytotoxic	19.66	Significant	3.42e-05	2.60	Specific	485	802
4	NK.adaptive_HLAE_tuned	19.22	Significant	7.08e-08	2.80	—	1,124	189
5	NK.adaptive_biosynthetic_primed	18.39	Significant	0.24	1.56	Relevant	244	405
6	NK.adaptive_axis_baseline	17.82	Significant	3.34e-05	2.53	—	1,008	153
7	T.CD8_Tem.motility_primed	16.68	Significant	0.53	1.23	—	269	4
8	T.CD8_Tcm.gut_homing	16.64	Significant	4.92e-03	2.20	—	380	112
9	T.CD4_cytotoxic.NK_adapted	16.58	Significant	0.08	2.04	—	82	33
10	T.CD8_naive.mito_proteostasis	16.36	Significant	2.52e-03	2.35	—	428	100
11	NK.adaptive_adipose_stress	16.04	Significant	0.36	1.41	—	374	39
12	T.CD8_Tem.signaling_turnover	15.96	Significant	0.53	1.36	Relevant	425	683
13	T.CD8_Tem.early_helper_like	15.76	Significant	0.53	1.23	Specific	445	755
14	NK.cytokine_repair_primed	15.60	Significant	0.41	1.34	—	266	11
15	NK.cytokine_quiescent	15.33	Significant	1.00	0.90	Relevant	623	1,062
16	T.CD8_Tem.stress_adapted	15.25	Significant	0.97	0.70	—	607	520
17	T.CD4_cytotoxic.precursor	15.16	Significant	0.39	1.50	—	156	67
18	NK.cytokine_vascular_patrolling	15.02	Significant	1.00	0.85	—	863	94
19	T.CD4_cytotoxic.activated	14.97	Significant	0.61	1.08	Relevant	3	1
20	T.CD4_naive.neddylation_mitoprot	14.96	Significant	0.34	1.48	—	93	56
21	T.CD8_Trm.cytotoxic	14.64	Significant	0.26	1.50	—	165	85
22	T.CD8_Tem.baseline	14.61	Significant	0.97	0.87	—	458	356
23	T.CD4_cytotoxic.terminal_effector	14.47	Significant	0.61	1.00	—	286	21
24	T.CD4_naive.mature_mitoprot	14.21	Significant	1.00	1.00	Specific	212	476
25	NK.cytokine_axis_baseline	14.14	Significant	1.00	0.64	—	1,172	116
26	T.CD8_Trm.homeostatic	14.06	Significant	0.78	1.02	—	42	5
27	T.CD4_naive.homeostatic	14.00	Significant	1.00	1.10	—	215	108
28	NK.cytokine_biosynthetic_primed	13.98	Significant	1.00	0.75	—	360	21
29	T.CD8_Tem.TEMRA	13.86	Significant	0.97	0.43	—	920	1,088
30	T.CD4_Tcm.crosstalk_myeloid	13.82	Significant	0.55	1.55	—	5	4
31	T.CD4_naive.survival	13.74	Significant	1.00	1.02	Relevant	12	17
32	T.CD4_naive.purinergic	13.49	Significant	1.00	0.64	—	49	1
33	T.CD4_naive.survival_mitoprot	13.43	Significant	1.00	0.96	—	13	7
34	T.CD4_naive.neddylation	13.37	Significant	1.00	1.02	Relevant	104	222
35	T.CD4_transitional.primed_cytotoxic	13.36	Significant	0.26	1.43	—	28	30
36	T.CD4_Tfh.effector_migratory	13.29	Significant	0.21	1.46	—	122	57
37	EC.capillary.postcap_venule	13.21	Significant	0.07	1.43	—	355	261
38	T.CD4_naive.survival_neddylation	13.19	Significant	1.00	0.71	Relevant	26	38
39	T.CD4_Tcm.secretory	13.17	Significant	0.55	1.35	—	20	11
40	T.CD4_naive.mature	13.08	Significant	1.00	0.90	—	211	100
41	NK.cytokine_tissue_activation	13.05	Significant	1.00	0.38	Relevant	267	450
42	T.MAIT.cytotoxic	13.04	Significant	0.05	2.07	—	52	15
43	ILC2.quiescent	12.86	Significant	—	0.59	Relevant	0	0
44	NK.adaptive_immature_precursor	12.71	Significant	1.00	0.14	—	358	111
45	T.CD8_Tcm.baseline	12.69	Significant	0.96	0.92	—	90	89
46	T.MAIT.stress	12.68	Significant	—	0.11	—	0	0
47	T.CD4_Tcm.retro_ZNF117	12.60	Significant	0.64	1.26	Relevant	5	9
48	T.CD8_naive.innate_like	12.42	Significant	1.00	0.85	—	10	1
49	T.CD4_Tcm.regulatory_poised	12.42	Significant	0.55	1.43	—	2	3
50	T.CD4_Tcm.baseline	12.40	Significant	0.84	1.07	—	61	31
51	T.CD8_Trm.dendritic_recruiter	12.36	Significant	0.84	0.61	Relevant	47	85
52	T.CD4_Th17.baseline	12.35	Significant	0.60	1.29	—	51	5
53	T.CD4_naive.Treg_like	12.32	Significant	1.00	0.83	—	121	72
54	T.CD8_transitional.effector_primed	12.28	Significant	0.06	1.65	—	435	151
55	T.CD4_Tcm.effector_like	12.24	Significant	0.55	1.46	Relevant	293	533
56	T.CD4_cytotoxic.baseline	12.21	Significant	0.93	0.32	—	0	0
57	T.CD4_Tem.inflammatory	12.16	Significant	0.14	1.65	—	28	6
58	T.CD4_naive.resist_bystander	12.13	Significant	1.00	0.89	—	40	25
59	T.MAIT.quiescent	12.11	Significant	0.42	1.47	—	100	5
60	T.CD4_transitional.baseline	12.09	Significant	0.01	1.88	Specific	59	97
61	EC.capillary.migratory	12.07	Significant	0.07	1.50	Relevant	181	509
62	T.CD8_transitional.early	12.04	Significant	0.47	1.09	—	327	55
63	T.CD8_transitional.Trm_primed	12.02	Significant	0.47	1.15	—	108	15
64	T.CD8_Trm.muscosal_Tc17	11.96	Significant	0.78	1.06	Relevant	19	38
65	T.CD4_Tcm.DC_interact	11.96	Significant	0.87	1.01	—	72	32
66	T.CD4_naive.proteostasis_mitoprot	11.92	Significant	1.00	0.40	Relevant	15	37
67	T.CD4_Tem.long_term_memory	11.78	Significant	0.18	1.48	Relevant	314	587
68	T.gamma_delta.central_memory	11.77	Significant	0.64	0.96	Relevant	460	919
69	T.CD8_naive.baseline	11.77	Significant	0.16	1.50	—	142	2
70	T.CD8_Tcm.helper_like	11.76	Significant	0.96	0.96	Relevant	81	159
71	T.CD8_naive.splicing_enriched	11.69	Significant	0.16	1.50	—	120	16
72	T.CD8_naive.vesicle_secretory	11.57	Significant	1.00	0.82	—	42	0
73	T.CD8_Trm.inflammatory	11.57	Significant	0.84	0.71	Relevant	124	176
74	NK.immature_bridge	11.50	Significant	1.00	0.03	—	117	122
75	T.CD4_Tfh.precursor_migratory	11.42	Significant	0.21	1.45	—	72	27
76	T.CD4_Tcm.stress	11.40	Significant	0.55	1.40	Relevant	5	11
77	T.MAIT.migratory	11.30	Significant	0.77	0.80	—	10	1
78	EC.venous.adipose_lipid	11.30	Significant	0.06	1.60	Specific	254	476
79	T.CD4_Tcm.RNA_control	11.28	Significant	0.64	1.19	—	96	4
80	NK.cytokine_tissue_resident	11.26	Significant	1.00	0.13	—	74	82
81	T.CD8_Tcm.effector_bias	11.17	Significant	1.00	0.34	Relevant	199	329
82	T.CD4_Trm.cytotoxic_effector	11.17	Significant	0.07	1.69	—	118	77
83	T.gamma_delta.cytotoxic_effector	11.13	Significant	0.36	1.43	—	349	109
84	T.CD4_Tcm.synapse_dynamics	11.13	Significant	0.88	0.73	—	15	10
85	EC.capillary.angiocrine	11.11	Significant	0.66	1.12	Relevant	250	630
86	T.CD4_Trm.central_like	11.05	Significant	0.57	1.14	—	38	31
87	T.MAIT.vesicle	10.91	Significant	0.77	0.80	Relevant	37	65
88	T.CD8_naive.cytokine_dampened	10.78	Significant	1.00	0.63	—	71	4
89	T.CD4_Tem.cytotoxic_effector	10.72	Significant	0.85	0.86	Relevant	225	398
90	T.CD4_Th17.cytotoxic	10.65	Significant	0.96	0.61	—	332	123
91	T.CD8_transitional.APC_like	10.63	Significant	0.99	0.39	—	205	62
92	T.CD8_naive.nfkb_related	10.62	Significant	1.00	0.66	—	1	0
93	T.CD4_Tcm.imprinted_splicing	10.62	Significant	0.88	0.78	Relevant	6	17
94	T.MAIT.early_activation	10.60	Significant	0.77	1.04	—	57	4
95	T.CD4_naive.proteostasis	10.60	Significant	1.00	0.35	—	14	9
96	T.CD4_Tcm.tissue_homing	10.57	Significant	0.88	0.79	—	78	46
97	T.gamma_delta.early_effector	10.49	Significant	0.64	0.87	—	89	0
98	T.CD4_Trm.stress_adaptive	10.44	Significant	0.57	1.14	—	8	22
99	T.CD4_Tcm.Tfh_like	10.33	Significant	0.88	0.82	Relevant	102	214
100	T.CD4_Trm.helper_like	10.24	Significant	0.73	0.98	Relevant	84	147
101	T.CD4_Tcm.migratory_cilium	10.11	Significant	0.88	0.73	—	5	10
102	T.MAIT.MAPK_brake	10.11	Significant	0.97	0.31	Relevant	44	66
103	T.CD8_naive.effector_transition	10.01	Significant	1.00	0.19	Relevant	35	62
104	NK.cytokine_lung_immediate_early	9.94	Significant	1.00	0.01	—	424	274
105	T.CD4_Tcm.Th2_like	9.83	Significant	1.00	0.28	Relevant	23	55
106	DC.cDC2.lipid_metabolic	9.69	Significant	—	0.88	Relevant	0	0
107	T.CD4_Trm.baseline	9.56	Significant	0.57	1.15	—	31	21
108	EC.capillary.baseline	9.39	Significant	1.00	0.99	Relevant	246	560
109	T.CD4_Tfh.suppression_exhaustion	9.00	Significant	0.98	0.62	—	0	2
110	T.CD4_Th17.migratory	8.93	Significant	0.96	0.41	Relevant	13	23
111	T.CD4_Th2.tissue_adapted	8.87	Significant	—	0.97	—	0	0
112	T.CD8_naive.lipid_synthesis	8.86	Significant	1.00	0.39	—	6	4
113	EPI.renal_proximal_tubule.detox_antioxidant	8.60	Significant	9.44e-03	2.41	—	394	77
114	HPC.MPP_activated	8.44	Significant	—	0.98	Relevant	0	0
115	T.CD4_Tem.transitional_CM	8.40	Significant	1.00	0.09	—	31	20
116	EC.capillary.stress	8.22	Significant	1.00	0.73	Relevant	44	36
117	EPI.skin_interfollicular_spinous.early_differentiation	7.97	Significant	0.12	1.66	—	89	19
118	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	7.96	Significant	—	0.42	—	0	0
119	EPI.skin_interfollicular_spinous.baseline	7.88	Significant	0.06	2.04	—	35	3
120	EC.venous.quiescent_homeostatic	7.62	Significant	0.10	1.43	Relevant	456	360
121	T.CD4_Tcm.APC_mimicry	7.57	Significant	1.00	0.09	—	54	43
122	EPI.skin_interfollicular_spinous.stress_UPR	7.47	Significant	—	0.29	—	0	0
123	EPI.skin_interfollicular_spinous.proliferative	7.29	Significant	—	0.07	—	0	0
124	HPC.MPP_IEG	7.14	Significant	0.64	1.39	Relevant	45	46
125	T.CD4_transitional.primed_helper_effector	6.98	Significant	1.00	0.36	Relevant	19	43
126	EPI.skin_interfollicular_spinous.stress_oxidative	6.91	Significant	—	0.24	—	0	0
127	EPI.tracheal_basal.homeostatic_progenitor	6.90	Significant	0.21	1.70	—	285	74
128	T.CD4_Treg.central_naive_like	6.89	Significant	1.72e-06	2.34	—	333	45
129	ASPC.preadipocyte_lipid_primed	6.87	Significant	1.07e-09	1.91	Specific	331	129
130	T.CD4_Trm.metal_stress	6.83	Significant	1.00	0.39	Relevant	34	58
131	T.CD8_Tcm.NK_like	6.71	Significant	1.00	0.00	Relevant	334	581
132	T.CD4_Tfh.canonical_GC_helper	6.70	Significant	0.98	0.24	—	1	2
133	ASPC.stem_like_progenitor	6.63	Significant	0.17	1.44	Relevant	300	842
134	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	6.55	Significant	—	1.15	Relevant	0	0
135	HPC.GMP_granulocytic	6.51	Significant	—	0.24	Relevant	3	3
136	T.CD4_Trm.activated	6.47	Significant	1.00	0.06	—	32	26
137	EC.arterial.metabolic	6.38	Significant	0.31	1.20	Other	195	159
138	EPI.renal_proximal_tubule.onecarbon_peroxisome	6.38	Significant	1.00	0.00	Relevant	58	89
139	HEP.periportal_metabolic.stress_chaperone	6.37	Significant	—	2.04	Other	66	128
140	DC.cDC1.homeostatic_inhibitory	6.36	Significant	—	1.21	Relevant	0	0
141	HPC.GMP_inflammatory	6.24	Significant	0.72	1.12	Relevant	20	10
142	DC.cDC2.proliferative	6.14	Significant	—	0.59	Relevant	39	71
143	T.CD4_naive.gut_prone	5.93	Significant	1.00	9.37e-03	Other	35	70
144	EC.venous.baseline	5.87	Significant	0.67	1.07	Other	346	807
145	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	5.85	Significant	—	0.00	Relevant	0	0
146	ASPC.activated	5.83	Significant	0.41	1.24	Relevant	164	162
147	T.CD4_Treg.Tr1_like	5.80	Significant	—	0.74	—	8	8
148	EPI.hepatic_ductular_cholangiocyte.ion_transport	5.79	Significant	—	1.86	Relevant	0	0
149	T.CD4_Th2.precursor	5.73	Significant	—	0.00	Relevant	0	0
150	EC.capillary.angiogenic_tip	5.69	Significant	1.00	0.46	Other	186	218
151	EPI.skin_interfollicular_spinous.upper_lipid	5.68	Significant	—	0.00	—	6	6
152	EPI.pancreatic_ductal_bicarbonate.stress	5.64	Significant	—	1.25	Other	12	33
153	EC.venous.remodeling_stalk	5.60	Significant	0.73	1.01	Relevant	559	566
154	EPI.tracheal_basal.activated_stress	5.47	Nominal	1.00	0.00	Other	32	0
155	ASPC.baseline	5.46	Nominal	1.00	1.02	Other	363	170
156	T.CD4_transitional.APC_interacting	5.45	Nominal	1.00	0.00	Other	10	14
157	T.CD4_transitional.tissue_enagement	5.40	Nominal	1.00	0.08	Other	5	11
158	EC.capillary.inflammatory	5.31	Nominal	1.00	0.27	Other	27	51
159	DC.cDC2.migratory	5.25	Nominal	0.73	1.40	Other	185	39
160	T.CD8_transitional.stress	5.10	Nominal	—	0.00	Other	24	34
161	EC.capillary.activated	5.07	Nominal	1.00	0.45	Other	2	5
162	EPI.skin_interfollicular_spinous.transition_basal	4.93	Nominal	1.00	0.00	Other	100	127
163	EPI.tracheal_suprabasal.transitional_wound	4.85	Nominal	—	0.60	Other	16	1
164	EPI.skin_interfollicular_spinous.inflammatory	4.84	Nominal	—	0.00	Other	0	0
165	EPI.skin_keratinocyte_proliferating.early_spinous_transition	4.76	Nominal	—	0.87	Other	135	290
166	DC.cDC2.antiviral	4.73	Nominal	0.92	0.85	Other	100	37
167	DC.cDC1.activated	4.69	Nominal	—	0.00	Other	0	0
168	DC.cDC2.pro_inflammatory	4.64	Nominal	0.73	1.29	Other	3	5
169	MAC.LAM.anti_inflammatory	4.47	Nominal	1.29e-03	1.85	Other	86	132
170	EC.arterial.inflammatory	4.44	Nominal	0.38	1.14	Other	63	50
171	HPC.LMPP	4.28	Nominal	0.78	0.72	Other	65	31
172	DC.cDC2.monocyte_like	4.18	Nominal	0.92	0.80	Other	1,285	791
173	DC.cDC1.proliferative	4.13	Nominal	—	0.00	Other	0	0
174	FIB.transitioning.matrix_stress	4.13	Nominal	—	0.31	Other	47	138
175	ASPC.secretory	4.05	Nominal	1.00	0.54	Other	76	5
176	FIB.interstitial.lipid_matrix	4.04	Nominal	4.57e-04	1.61	Other	258	191
177	DC.cDC1.cross_presenting	4.04	Nominal	—	0.00	Other	0	0
178	DC.cDC2.adhesion_signaling	4.03	Nominal	0.92	0.71	Other	35	9
179	EC.arterial.mito_contact	4.03	Nominal	0.38	1.16	Other	14	5
180	DC.cDC2.tolerogenic_regulatory	4.02	Nominal	0.96	0.42	Other	44	4
181	MAC.LAM.perivascular_angiocrine	4.01	Nominal	—	0.84	Other	53	138
182	T.CD4_Treg.tissue_effector	3.95	Nominal	0.38	1.25	Other	16	13
183	THYMO.DN_preTCR	3.94	Nominal	6.96e-09	2.18	Other	41	71
184	ILC2.activated	3.93	Nominal	—	0.00	Other	0	0
185	MAC.alveolar.capillary_interacting	3.88	Nominal	0.19	1.51	Other	113	181
186	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.88	Nominal	—	0.32	Other	0	0
187	FIB.transitioning.ISG_primed_interface	3.87	Nominal	—	0.31	Other	17	80
188	HPC.MEP	3.84	Nominal	0.78	0.82	Other	599	1,195
189	ASPC.inflammatory	3.80	Nominal	1.00	0.91	Other	21	61
190	MAC.alveolar.lipid_autophagy	3.79	Nominal	—	0.53	Other	35	44
191	MAC.alveolar.stress_metabolic	3.72	Nominal	0.18	1.62	Other	116	148
192	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	3.71	Nominal	—	0.85	Other	0	0
193	FIB.barrier_secretory.remodeling	3.67	Nominal	—	0.00	Other	0	0
194	MAC.alveolar.biosynthetic_sterol_heme	3.60	Nominal	0.14	1.80	Other	347	40
195	FIB.barrier_secretory.homeostasis	3.58	Nominal	—	0.17	Other	0	0
196	EC.venous.activated	3.58	Nominal	1.00	0.37	Other	247	752
197	EPI.bile_duct_cholangiocyte.secretory_mucin	3.56	Nominal	—	0.07	Other	7	12
198	B.naive.restrained	3.54	Nominal	1.01e-03	1.59	Other	183	353
199	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	3.37	Nominal	—	0.79	Other	49	237
200	MAC.LAM.antimicrobial	3.34	Nominal	0.23	1.33	Other	389	93
201	B.memory.preactivated	3.20	Nominal	8.33e-03	1.74	Other	173	174
202	HPC.CLP_B_primed	3.05	Nominal	—	0.00	Other	0	0
203	EPI.bile_duct_cholangiocyte.inflammatory_APC	2.97	Nonsignificant	—	0.00	Other	2	0
204	EC.arterial.angiogenic_tip	2.91	Nonsignificant	—	0.00	Other	30	37
205	EC.arterial.elastic	2.77	Nonsignificant	0.92	0.94	Other	22	45
206	B.naive.activated	2.76	Nonsignificant	0.83	1.14	Other	77	127
207	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.72	Nonsignificant	0.67	1.27	Other	40	191
208	THYMO.SP_CD8_transitional	2.70	Nonsignificant	0.04	1.72	Other	32	75
209	MAC.LAM.lipid_phagocytosis	2.68	Nonsignificant	0.84	0.88	Other	369	328
210	FIB.reticular.stress_metallothionein	2.67	Nonsignificant	—	0.82	Other	3	32
211	FIB.interstitial.stress_secretory	2.61	Nonsignificant	0.45	1.22	Other	92	56
212	FIB.transitioning.secretory_procollagen	2.61	Nonsignificant	—	0.00	Other	0	0
213	EC.arterial.arteriole_gas_exchange	2.55	Nonsignificant	0.92	0.96	Other	238	131
214	MAC.MDM.LAM_like	2.52	Nonsignificant	0.20	1.43	Other	12	14
215	MAC.proliferating.stress	2.45	Nonsignificant	—	0.57	Other	87	136
216	MAC.alveolar.inflammatory	2.44	Nonsignificant	0.99	0.12	Other	208	312
217	EPI.pancreatic_ductal_bicarbonate.inflammatory	2.44	Nonsignificant	0.67	1.03	Other	14	32
218	T.CD4_Treg.APC_interactive	2.44	Nonsignificant	1.00	0.00	Other	118	28
219	DC.mig.baseline	2.42	Nonsignificant	—	0.00	Other	1	0
220	FIB.transitioning.motility_remodelling	2.38	Nonsignificant	—	0.00	Other	0	0
221	EPI.pancreatic_ductal_bicarbonate.activated	2.37	Nonsignificant	0.67	1.03	Other	10	7
222	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	2.34	Nonsignificant	0.67	0.97	Other	219	533
223	B.naive.proteostasis	2.28	Nonsignificant	0.40	1.35	Other	49	69
224	EC.arterial.arteriole_interface	2.28	Nonsignificant	0.92	0.99	Other	31	12
225	THYMO.proliferative_S	2.24	Nonsignificant	0.04	1.59	Other	163	418
226	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	2.23	Nonsignificant	—	1.15	Other	0	0
227	EPI.extrahepatic_cholangiocyte.barrier_interface	2.23	Nonsignificant	—	0.73	Other	0	0
228	MAC.alveolar.scavenging_endocytic	2.22	Nonsignificant	—	0.00	Other	140	283
229	FIB.interstitial.mesenchymal_APC	2.14	Nonsignificant	0.45	1.15	Other	81	33
230	EPI.pancreatic_ductal_bicarbonate.baseline	2.07	Nonsignificant	0.92	0.49	Other	11	42
231	B.naive.purinergic	2.06	Nonsignificant	1.00	0.71	Other	384	820
232	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.01	Nonsignificant	—	0.70	Other	0	0
233	MAC.MDM.APC_dendritic	1.99	Nonsignificant	0.33	1.21	Other	48	15
234	B.naive.antigen_presenting_ready	1.98	Nonsignificant	1.00	0.67	Other	48	73
235	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.98	Nonsignificant	—	0.00	Other	0	0
236	B.naive.metabolic	1.93	Nonsignificant	1.00	0.87	Other	50	79
237	EC.lymphatic.valve	1.92	Nonsignificant	—	0.67	Other	0	0
238	DC.cDC1.baseline	1.90	Nonsignificant	—	0.00	Other	0	0
239	MAC.LAM.inflammatory_APC	1.90	Nonsignificant	1.00	0.41	Other	872	165
240	EC.lymphatic.activated	1.83	Nonsignificant	0.50	1.11	Other	47	73
241	EPI.skin_keratinocyte_proliferating.anchor_remodel	1.82	Nonsignificant	—	0.00	Other	0	0
242	EPI.hepatic_ductular_cholangiocyte.polarity	1.77	Nonsignificant	—	0.51	Other	0	0
243	EPI.skin_follicular_keratinizing.transit_amplifying	1.77	Nonsignificant	—	0.64	Other	21	49
244	THYMO.CD8aa_IELp	1.75	Nonsignificant	—	0.86	Other	1	7
245	ILC2.migratory	1.73	Nonsignificant	—	0.00	Other	0	0
246	ASPC.adipocyte_capillary_interface	1.72	Nonsignificant	1.00	0.07	Other	21	54
247	EPI.salivary_serous_acinar.secretory_active	1.72	Nonsignificant	1.15e-14	2.68	Other	242	69
248	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	1.72	Nonsignificant	—	1.57	Other	39	82
249	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.69	Nonsignificant	—	0.39	Other	6	9
250	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.69	Nonsignificant	—	1.13	Other	0	0
251	B.memory.activated	1.64	Nonsignificant	0.74	1.13	Other	105	29
252	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.64	Nonsignificant	—	0.25	Other	0	0
253	EPI.pancreatic_ductal_perivascular.protective_antioxidant	1.63	Nonsignificant	—	0.22	Other	11	69
254	EPI.salivary_mucous_acinar.baseline	1.63	Nonsignificant	—	—	Other	394	683
255	GRNLSA.proliferative_migratory	1.61	Nonsignificant	2.78e-03	1.74	Other	248	292
256	IPSC.stress	1.59	Nonsignificant	0.03	1.29	Other	0	0
257	FIB.reticular.immune_interface	1.59	Nonsignificant	—	0.23	Other	1	6
258	B.naive.remodeling	1.58	Nonsignificant	1.00	0.51	Other	135	230
259	MAC.resident_iron.redox_metabolic	1.57	Nonsignificant	0.01	1.64	Other	4	4
260	ASPC.niche_keeping_progenitor	1.55	Nonsignificant	1.00	0.10	Other	52	219
261	MAC.proliferating.DNA_replication	1.55	Nonsignificant	0.92	0.47	Other	3	6
262	THYMO.DP_early_stress	1.51	Nonsignificant	—	0.87	Other	0	0
263	GRANU.MAST.activated_acute	1.51	Nonsignificant	—	0.66	Other	0	0
264	ASPC.proliferative	1.49	Nonsignificant	1.00	0.36	Other	33	85
265	EC.arterial.homeostatic	1.48	Nonsignificant	0.98	0.74	Other	24	3
266	B.memory.baseline	1.44	Nonsignificant	0.97	0.70	Other	472	99
267	FIB.interstitial.immune_interact	1.44	Nonsignificant	1.00	0.64	Other	12	1
268	EC.arterial.ion_pump	1.42	Nonsignificant	0.94	0.84	Other	3	2
269	EPI.skin_follicular_keratinizing.upper_infundibulum	1.41	Nonsignificant	—	0.00	Other	8	2
270	FIB.reticular.ECM_builder	1.41	Nonsignificant	—	0.47	Other	0	0
271	EC.lymphatic.tip_migratory	1.40	Nonsignificant	0.50	1.14	Other	23	37
272	MAC.resident_repair.lipid_phagocytic	1.39	Nonsignificant	0.05	1.54	Other	228	604
273	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.39	Nonsignificant	—	0.92	Other	0	0
274	EPI.skin_keratinocyte_basal.basement_anchoring	1.35	Nonsignificant	—	0.97	Other	0	0
275	FIB.tracheal_subepithelial.baseline	1.35	Nonsignificant	—	0.00	Other	0	0
276	EPI.skin_keratinocyte_basal.spinous_transition	1.35	Nonsignificant	—	0.00	Other	0	0
277	B.naive.receptor_recycle	1.31	Nonsignificant	1.00	0.49	Other	51	0
278	MAC.MDM.inflammatory_phagocytic	1.30	Nonsignificant	0.97	0.78	Other	199	52
279	MAC.microglia_like.inflammatory_chemokine	1.28	Nonsignificant	—	0.69	Other	20	32
280	MAC.LAM.lipid_opsonization	1.27	Nonsignificant	0.84	0.88	Other	45	14
281	HEP.periportal_metabolic.canonical_urea_cycle	1.26	Nonsignificant	0.07	1.42	Other	1,464	269
282	PERI.baseline	1.22	Nonsignificant	0.13	1.12	Other	39	66
283	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	1.22	Nonsignificant	—	1.46	Other	0	0
284	MAC.MDM.complement_resolving	1.21	Nonsignificant	0.97	0.64	Other	440	860
285	EPI.pancreatic_ductal_perivascular.baseline	1.21	Nonsignificant	0.69	0.69	Other	1	5
286	THYMO.proliferative_G2M	1.19	Nonsignificant	—	0.33	Other	164	413
287	GRANU.MAST.activated_repair	1.19	Nonsignificant	—	0.00	Other	0	1
288	PERI.inflammatory	1.19	Nonsignificant	0.08	1.16	Other	40	77
289	B.memory.migratory	1.18	Nonsignificant	0.97	0.78	Other	123	208
290	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.16	Nonsignificant	—	0.41	Other	43	26
291	FIB.interstitial.mesenchymal_regulator	1.13	Nonsignificant	1.00	0.66	Other	4	4
292	MONO.CD14.APC_like	1.10	Nonsignificant	0.21	1.14	Other	1,686	2,493
293	EPI.salivary_myoepithelial.contractile_repair	1.10	Nonsignificant	—	1.62	Other	3	9
294	DC.pDC.poised_migratory	1.09	Nonsignificant	0.19	1.42	Other	54	95
295	EPI.colonocyte.secretory_boost	1.07	Nonsignificant	0.12	1.47	Other	98	91
296	ASPC.remodeling	1.06	Nonsignificant	1.00	0.07	Other	106	354
297	EPI.pancreatic_ductal_progenitor.ADM_like	1.05	Nonsignificant	—	1.07	Other	0	0
298	EPI.skin_keratinocyte_basal.transit_amplifying	1.04	Nonsignificant	—	0.00	Other	0	0
299	B.naive.baseline	1.04	Nonsignificant	1.00	0.21	Other	10	13
300	EPI.skin_follicular_keratinizing.root_infundibulum	1.02	Nonsignificant	—	0.00	Other	0	0
301	MONO.CD16.platelet_bound	1.00	Nonsignificant	0.04	1.49	Other	372	508
302	ASTRO.stress_acute	1.00	Nonsignificant	1.00	1.01	Other	60	56
303	EPI.tracheal_suprabasal.secretory_immune	0.97	Nonsignificant	—	0.00	Other	0	0
304	GRANU.MAST.resting_granule	0.96	Nonsignificant	—	0.00	Other	0	0
305	ASTRO.A1_reactive	0.95	Nonsignificant	1.00	1.06	Other	433	394
306	EPI.skin_sweat_duct_keratinocyte.barrier	0.95	Nonsignificant	—	0.20	Other	0	0
307	HEP.periportal_metabolic.xenobiotic_detox	0.94	Nonsignificant	1.00	1.09	Other	1,440	139
308	EC.lymphatic.baseline	0.92	Nonsignificant	0.85	0.93	Other	38	72
309	MONO.CD14.cord_tolerance	0.92	Nonsignificant	0.21	1.15	Other	864	753
310	B.age_associated.migratory	0.92	Nonsignificant	0.28	1.27	Other	2	2
311	THYMO.SP_CD8_naive	0.91	Nonsignificant	0.96	0.98	Other	297	177
312	EPI.salivary_duct_excretory.stress	0.89	Nonsignificant	0.35	1.17	Other	33	68
313	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.88	Nonsignificant	—	0.46	Other	105	368
314	B.germinal_center.LZ_survival	0.87	Nonsignificant	—	0.79	Other	0	0
315	EPI.salivary_duct_excretory.baseline	0.87	Nonsignificant	0.35	1.37	Other	23	57
316	EPI.skin_sweat_duct_keratinocyte.repair	0.84	Nonsignificant	—	0.00	Other	0	0
317	B.age_associated.naive_transitional	0.82	Nonsignificant	—	0.13	Other	0	0
318	B.germinal_center.LZ_selection	0.81	Nonsignificant	—	0.73	Other	0	0
319	B.germinal_center.LZ_memory_precursor	0.80	Nonsignificant	—	0.37	Other	0	0
320	SMC.activated	0.80	Nonsignificant	0.60	1.03	Other	2	5
321	FIB.interstitial.remodeling	0.79	Nonsignificant	1.00	0.13	Other	31	9
322	B.memory.pDC_imprint	0.79	Nonsignificant	0.97	0.30	Other	157	103
323	EPI.esophageal_basal.activated_progenitor	0.78	Nonsignificant	0.12	1.87	Other	1	0
324	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.78	Nonsignificant	—	0.00	Other	5	3
325	THYMO.SP_CD4_naive	0.77	Nonsignificant	1.00	0.42	Other	65	75
326	EPI.pancreatic_ductal_progenitor.baseline	0.75	Nonsignificant	1.00	0.00	Other	179	702
327	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.74	Nonsignificant	—	0.59	Other	0	0
328	SMC.metabolic	0.73	Nonsignificant	0.39	1.16	Other	14	40
329	EPI.colonic_enteroendocrine.progenitor	0.72	Nonsignificant	—	0.97	Other	0	0
330	EPI.salivary_duct_ion_transport.baseline	0.72	Nonsignificant	—	—	Other	0	0
331	B.age_associated.activated	0.72	Nonsignificant	—	0.00	Other	18	22
332	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.71	Nonsignificant	—	0.00	Other	0	0
333	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.71	Nonsignificant	—	0.81	Other	0	0
334	EPI.renal_intercalated_cell_type_A.PC_transitional	0.70	Nonsignificant	—	0.31	Other	203	407
335	ASTRO.hypoxia_angiogenic	0.70	Nonsignificant	0.37	1.32	Other	5	18
336	HEP.periportal_metabolic.apolipoprotein_secretory	0.69	Nonsignificant	1.00	0.76	Other	43	110
337	EPI.skin_sebaceous_duct_luminal.detox_repair	0.69	Nonsignificant	0.19	1.53	Other	137	94
338	MAC.resident_iron.heme_catabolism	0.68	Nonsignificant	0.56	1.12	Other	30	51
339	MAC.resident_iron.APC_iron_sensing	0.67	Nonsignificant	0.74	0.82	Other	211	114
340	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.66	Nonsignificant	2.29e-03	1.54	Other	322	317
341	HEP.periportal_metabolic.urea_onecarbon_secretory	0.66	Nonsignificant	1.00	0.86	Other	1,332	3,053
342	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.65	Nonsignificant	—	0.00	Other	0	0
343	FIB.reticular.stromal_niche	0.65	Nonsignificant	1.00	0.00	Other	0	0
344	EPI.renal_principal_cell.inflammatory	0.65	Nonsignificant	0.31	1.64	Other	74	157
345	MONO.CD14.repair_M2_like	0.65	Nonsignificant	0.30	1.07	Other	550	1,495
346	ASPC.mesothelial_like	0.65	Nonsignificant	1.00	0.63	Other	143	486
347	EPI.alveolar_type_1.activated	0.64	Nonsignificant	—	1.64	Other	0	0
348	GRNLSA.secretory_remodeling	0.63	Nonsignificant	0.98	1.14	Other	90	25
349	MAC.resident_iron.stress_tolerogenic	0.62	Nonsignificant	—	0.23	Other	0	0
350	EPI.pancreatic_islet.beta	0.62	Nonsignificant	3.83e-03	1.45	Other	42	57
351	THYMO.SP_CD8_naive_stress	0.62	Nonsignificant	1.00	0.52	Other	1	1
352	EPI.skin_hair_follicle_bulge.quiescent	0.62	Nonsignificant	4.72e-04	2.56	Other	56	69
353	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.62	Nonsignificant	—	0.42	Other	19	54
354	EPI.salivary_intercalated_defense.basal_EMT	0.62	Nonsignificant	—	0.29	Other	0	0
355	ASTRO.neuromodulatory	0.60	Nonsignificant	1.00	1.05	Other	34	172
356	EPI.renal_principal_cell.canonical_vasopressin	0.60	Nonsignificant	0.88	1.01	Other	2	0
357	EPI.salivary_intercalated_defense.inflammatory	0.59	Nonsignificant	0.33	1.24	Other	152	360
358	EPI.renal_principal_cell.activated_acute	0.59	Nonsignificant	0.54	1.35	Other	29	59
359	EPI.ileal_enterocyte_crypt.baseline	0.58	Nonsignificant	0.64	1.06	Other	11	6
360	FIB.perivascular_interface.lipid_shuttle	0.57	Nonsignificant	—	0.51	Other	51	170
361	EPI.renal_immature_ureteric_bud.osmoprotective	0.57	Nonsignificant	0.76	0.78	Other	126	44
362	EPI.hepatic_ductular_cholangiocyte.stress	0.57	Nonsignificant	—	0.00	Other	0	0
363	EPI.renal_immature_ureteric_bud.defense_secretory	0.57	Nonsignificant	0.76	1.12	Other	45	76
364	EPI.alveolar_type_1.baseline	0.56	Nonsignificant	1.00	0.00	Other	8	0
365	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.55	Nonsignificant	—	0.00	Other	0	0
366	EPI.esophageal_suprabasal.basal_transitional	0.54	Nonsignificant	0.17	1.60	Other	44	67
367	GRNLSA.stress_metabolic	0.52	Nonsignificant	—	0.49	Other	1	2
368	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.51	Nonsignificant	0.33	1.17	Other	11	22
369	PERI.angiocrine	0.51	Nonsignificant	1.00	0.89	Other	93	102
370	MONO.CD16.inflammatory	0.49	Nonsignificant	0.02	1.31	Other	1,640	168
371	THYMO.DP_early	0.49	Nonsignificant	1.00	0.00	Other	326	313
372	EPI.renal_principal_cell.intercalated_like	0.46	Nonsignificant	0.96	0.67	Other	63	66
373	MAC.microglia_like.phagocytic_redox	0.46	Nonsignificant	—	0.00	Other	0	0
374	MONO.CD16.hepatic_mac_like	0.46	Nonsignificant	0.23	1.20	Other	803	117
375	HEP.acute_phase.baseline	0.45	Nonsignificant	1.38e-03	1.91	Other	946	19
376	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	0.45	Nonsignificant	—	0.00	Other	0	0
377	EPI.ileal_enterocyte_crypt.bile_transport	0.45	Nonsignificant	0.53	1.21	Other	2	0
378	MAC.resident_repair.antigen_presenting	0.44	Nonsignificant	0.18	1.27	Other	244	113
379	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.43	Nonsignificant	0.83	0.58	Other	449	1,034
380	EPI.esophageal_basal.junctional_barrier	0.42	Nonsignificant	—	0.00	Other	0	0
381	DC.pDC.immature_metabolic	0.42	Nonsignificant	0.91	0.96	Other	78	124
382	EPI.tracheal_submucosal_gland.ductal_luminal	0.40	Nonsignificant	—	0.00	Other	0	0
383	FIB.barrier_purinergic.stress_GF_binding	0.39	Nonsignificant	—	0.97	Other	0	0
384	EPI.lung_club_secretory.inflammatory	0.39	Nonsignificant	—	1.47	Other	0	0
385	EPI.skin_sebaceous_duct_luminal.immune_interface	0.38	Nonsignificant	—	0.27	Other	0	0
386	MEL.mature_oxidative_traffic	0.38	Nonsignificant	6.05e-03	2.06	Other	247	285
387	HEP.acute_phase.complement_antiviral	0.38	Nonsignificant	0.84	1.11	Other	377	751
388	HEP.acute_phase.stress_secretory	0.37	Nonsignificant	0.84	0.98	Other	26	3
389	EPI.gastric_foveolar.baseline	0.36	Nonsignificant	—	0.00	Other	0	0
390	B.germinal_center.DZ_M_phase	0.36	Nonsignificant	—	0.00	Other	0	0
391	EPI.skin_sweat_duct_keratinocyte.proliferative_S	0.36	Nonsignificant	—	0.00	Other	0	0
392	EPI.esophageal_suprabasal.differentiating_keratin	0.36	Nonsignificant	0.27	1.26	Other	131	61
393	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.36	Nonsignificant	—	0.00	Other	29	88
394	EPI.ileal_enterocyte_crypt.proliferative_S	0.35	Nonsignificant	0.64	0.95	Other	4	2
395	EPI.tracheal_submucosal_gland.acinar_serous	0.34	Nonsignificant	—	0.00	Other	0	0
396	GRNLSA.EMT_insulin_signaling	0.33	Nonsignificant	0.98	0.64	Other	47	84
397	EPI.renal_intercalated_cell_type_B.baseline	0.33	Nonsignificant	—	0.00	Other	3	1
398	EPI.renal_principal_cell.injury_repair	0.32	Nonsignificant	0.96	0.27	Other	26	9
399	MAC.resident_repair.chemokine_angiocrine	0.31	Nonsignificant	0.97	0.81	Other	87	138
400	EPI.skin_keratinocyte_proliferating.detox_repair	0.30	Nonsignificant	—	0.00	Other	0	0
401	HEP.acute_phase.complement_metabolic	0.30	Nonsignificant	0.99	0.41	Other	1,423	3,464
402	DC.pDC.baseline	0.30	Nonsignificant	0.91	0.56	Other	88	123
403	GRNLSA.lipid_hypoxia	0.29	Nonsignificant	0.98	0.49	Other	28	0
404	EC.heart_remodeling.activated_acute	0.29	Nonsignificant	0.49	1.28	Other	102	186
405	HEP.periportal_metabolic.inflammatory_activated	0.28	Nonsignificant	1.00	0.44	Other	712	1,610
406	SMC.contractile	0.28	Nonsignificant	1.00	0.56	Other	80	588
407	MUSC.baseline	0.28	Nonsignificant	0.40	1.34	Other	0	0
408	GRNLSA.chemokine_mechanosensory	0.28	Nonsignificant	0.98	0.56	Other	1	0
409	FIB.perivascular_interface.vasomotor_tone	0.28	Nonsignificant	—	0.17	Other	0	0
410	MONO.CD14.remodeling	0.28	Nonsignificant	0.36	1.03	Other	2,373	295
411	HEP.acute_phase.inflammatory	0.28	Nonsignificant	0.99	0.58	Other	382	649
412	B.germinal_center.DZ_S_phase	0.27	Nonsignificant	—	0.00	Other	0	0
413	EPI.skin_keratinocyte_progenitor.activated_stress	0.27	Nonsignificant	—	0.00	Other	0	0
414	FIB.barrier_purinergic.lipid_secretory	0.26	Nonsignificant	—	0.00	Other	0	0
415	HEP.acute_phase.proliferative	0.26	Nonsignificant	—	0.00	Other	4	6
416	MUSC.activated_migratory	0.26	Nonsignificant	0.40	1.24	Other	6	7
417	MEL.secretory_quiescent	0.25	Nonsignificant	0.93	0.48	Other	19	13
418	EPI.ileal_enterocyte_crypt.secretory_precursor	0.25	Nonsignificant	—	0.34	Other	0	0
419	MEL.dedifferentiated_migratory	0.24	Nonsignificant	—	0.00	Other	0	0
420	OLG.regulatory	0.24	Nonsignificant	8.44e-03	1.26	Other	353	73
421	EPI.renal_thick_ascending_limb.barrier_repair	0.23	Nonsignificant	0.98	0.80	Other	141	284
422	EPI.ileal_goblet.immature	0.23	Nonsignificant	—	1.59	Other	0	0
423	EPI.esophageal_suprabasal.proliferative_S	0.23	Nonsignificant	—	0.00	Other	26	41
424	MEL.stress_glucocorticoid	0.22	Nonsignificant	0.66	1.05	Other	11	34
425	EC.heart_remodeling.translation_boost	0.22	Nonsignificant	—	1.30	Other	0	0
426	MEL.neurotrophic_migratory	0.22	Nonsignificant	—	0.00	Other	0	0
427	FIB.neurolectin_mucosa.nerve_interface	0.22	Nonsignificant	—	0.87	Other	4	0
428	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.22	Nonsignificant	—	0.00	Other	0	0
429	MUSC.quiescent_reservoir	0.21	Nonsignificant	0.40	1.26	Other	2	8
430	EC.venous.cardiac_structural	0.21	Nonsignificant	1.00	0.00	Other	102	229
431	EPI.renal_thick_ascending_limb.remodeling	0.21	Nonsignificant	0.98	0.70	Other	152	92
432	GRNLSA.cholesterol_mevalonate	0.20	Nonsignificant	0.98	0.17	Other	9	4
433	MONO.CD16.baseline	0.20	Nonsignificant	1.00	0.82	Other	50	1
434	FIB.perivascular_interface.vascular_BM_remodelling	0.20	Nonsignificant	—	0.00	Other	0	0
435	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.19	Nonsignificant	0.92	0.30	Other	2	9
436	EPI.alveolar_type_2.baseline_surfactant	0.19	Nonsignificant	0.01	1.65	Other	64	9
437	OLG.reactive_repair	0.18	Nonsignificant	0.41	1.11	Other	385	385
438	MAC.resident_repair.stress_iron	0.18	Nonsignificant	0.97	0.92	Other	48	97
439	EPI.esophageal_suprabasal.proliferative_exit	0.18	Nonsignificant	—	0.00	Other	0	0
440	OLG.vesicle_trafficking	0.18	Nonsignificant	0.39	1.15	Other	124	10
441	ASPC.signal_integrator	0.17	Nonsignificant	—	0.00	Other	0	0
442	ADIPO.thermogenic	0.17	Nonsignificant	—	0.78	Other	0	0
443	EPI.colonocyte.junction_remodeling	0.17	Nonsignificant	0.98	1.11	Other	218	305
444	FIB.hepatic_stellate_cell.fibrogenic	0.17	Nonsignificant	—	0.00	Other	0	0
445	OLG.stress	0.17	Nonsignificant	0.31	1.13	Other	232	8
446	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.16	Nonsignificant	0.77	0.66	Other	33	34
447	EPI.lung_club_secretory.canonical_surfactant	0.16	Nonsignificant	—	0.39	Other	74	104
448	MONO.CD14.platelet_bound	0.16	Nonsignificant	0.21	1.15	Other	964	176
449	GRNLSA.p53_damage	0.15	Nonsignificant	—	0.00	Other	13	10
450	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.15	Nonsignificant	—	1.44	Other	10	20
451	EPI.esophageal_suprabasal.proliferative_G2M	0.15	Nonsignificant	—	0.00	Other	0	0
452	EPI.renal_thick_ascending_limb.cation_flux	0.15	Nonsignificant	0.98	0.61	Other	57	95
453	PC.IgG_systemic.stress	0.15	Nonsignificant	—	0.75	Other	1	5
454	FIB.neurolectin_mucosa.remodeling_repair	0.15	Nonsignificant	—	0.50	Other	4	2
455	OLG.regulatory_activated	0.15	Nonsignificant	0.52	1.05	Other	196	614
456	EPI.skin_hair_follicle_bulge.anagen_growth	0.15	Nonsignificant	—	0.00	Other	0	0
457	FIB.lung_alveolar.mito_secretory	0.14	Nonsignificant	—	0.00	Other	0	0
458	EC.liver_sinusoidal.prostanoid	0.14	Nonsignificant	—	0.82	Other	11	64
459	FIB.hepatic_stellate_cell.contractile	0.14	Nonsignificant	—	0.32	Other	0	0
460	IPSC.canonical_pluripotent	0.14	Nonsignificant	1.00	1.07	Other	0	0
461	EPI.ectocervical_granular.proliferative_basal	0.14	Nonsignificant	—	1.15	Other	0	0
462	MAC.resident_iron.heme_recycling	0.14	Nonsignificant	—	0.00	Other	30	37
463	MUSC.early_activation	0.13	Nonsignificant	0.94	0.25	Other	4	32
464	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.13	Nonsignificant	—	0.00	Other	0	0
465	EC.heart_remodeling.remodeling_secretory	0.13	Nonsignificant	0.49	1.13	Other	605	1,341
466	ASTRO.immature_lipid	0.13	Nonsignificant	1.00	0.89	Other	23	113
467	MAC.resident_repair.ECM_stromal_crosstalk	0.13	Nonsignificant	0.97	0.62	Other	95	158
468	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.13	Nonsignificant	0.77	0.56	Other	7	16
469	PC.IgA_muocsal.baseline	0.12	Nonsignificant	0.23	1.25	Other	3	5
470	FIB.suburothelial.contractile_myofibroblast	0.12	Nonsignificant	—	0.60	Other	9	0
471	EPI.pancreatic_islet.delta	0.12	Nonsignificant	—	0.00	Other	0	0
472	EPI.colonic_enteroendocrine.Lcell_peptide	0.12	Nonsignificant	—	0.00	Other	0	0
473	EPI.pancreatic_acinar.stress	0.12	Nonsignificant	0.43	1.49	Other	28	28
474	EC.heart_remodeling.angiocrine	0.11	Nonsignificant	0.56	1.08	Other	182	525
475	FIB.hepatic_stellate_cell.inflammatory	0.11	Nonsignificant	—	0.00	Other	0	0
476	ADIPO.hypoxia_remodelling	0.11	Nonsignificant	—	0.33	Other	29	105
477	FIB.suburothelial.homeostasis_matrix	0.11	Nonsignificant	0.58	1.31	Other	258	921
478	EC.liver_sinusoidal.secretory_lipoprotein	0.11	Nonsignificant	0.69	1.09	Other	120	70
479	EPI.skin_appendage_keratinocyte.transit_amplifying	0.11	Nonsignificant	—	0.00	Other	109	358
480	FIB.suburothelial.inflammatory_prostanoid	0.11	Nonsignificant	—	0.00	Other	0	0
481	FIB.lung_alveolar.stress_interacting	0.10	Nonsignificant	—	0.00	Other	0	0
482	PC.IgG_systemic.secretory	0.10	Nonsignificant	0.60	1.23	Other	0	0
483	FIB.suburothelial.urothelial_interface	0.10	Nonsignificant	0.92	0.31	Other	9	8
484	PC.IgA_muocsal.migratory	0.10	Nonsignificant	0.96	1.00	Other	4	1
485	GRNLSA.angiocrine_mechanosensory	0.10	Nonsignificant	—	0.00	Other	0	0
486	MONO.CD14.baseline	0.10	Nonsignificant	1.00	0.65	Other	2,268	76
487	FIB.skin_neurosecretory.baseline	0.10	Nonsignificant	—	0.00	Other	0	0
488	EPI.skin_hair_follicle_companion.activated_migratory	0.10	Nonsignificant	—	0.97	Other	0	0
489	EC.liver_sinusoidal.inflammatory	0.09	Nonsignificant	—	0.57	Other	223	154
490	PC.IgA_muocsal.activated	0.09	Nonsignificant	0.96	0.90	Other	17	8
491	FIB.neurolectin_mucosa.inflammatory	0.09	Nonsignificant	0.99	0.41	Other	52	110
492	PC.IgG_systemic.interacting	0.09	Nonsignificant	0.87	0.96	Other	0	0
493	EPI.salivary_myoepithelial.junctional_transport	0.09	Nonsignificant	0.84	1.22	Other	66	121
494	HEP.periportal_metabolic.acute_phase_barrier	0.09	Nonsignificant	1.00	0.36	Other	533	138
495	MONO.CD14.inflammatory	0.09	Nonsignificant	0.30	1.17	Other	92	134
496	EPI.ileal_enterocyte_absorptive.villus_tip	0.09	Nonsignificant	0.51	1.13	Other	4	3
497	EPI.renal_intercalated_cell_type_A.acid_secretion	0.08	Nonsignificant	0.85	0.64	Other	12	6
498	EPI.renal_thick_ascending_limb.salt_sensing	0.08	Nonsignificant	0.98	0.61	Other	73	103
499	EPI.colonocyte.goblet_interface	0.08	Nonsignificant	—	0.00	Other	11	21
500	EPI.thymic_medullary.stress_APC	0.07	Nonsignificant	0.50	1.51	Other	2	4
501	HEP.canalicular_transport.secretory_ERAD_UPR	0.07	Nonsignificant	0.16	1.45	Other	232	28
502	EC.liver_sinusoidal.stress	0.07	Nonsignificant	—	0.38	Other	413	158
503	MAC.kupffer.monocyte_like	0.07	Nonsignificant	—	0.53	Other	0	0
504	EPI.salivary_serous_acinar.seromucous_like	0.07	Nonsignificant	—	0.00	Other	0	0
505	IPSC.neuroendocrine_primed	0.06	Nonsignificant	—	0.84	Other	0	0
506	HEP.periportal_metabolic.stress_checkpoint	0.06	Nonsignificant	1.00	0.86	Other	234	786
507	FIB.neurolectin_mucosa.axon_responsive	0.06	Nonsignificant	0.99	0.08	Other	10	10
508	EPI.lung_club_secretory.ciliogenesis_primed	0.06	Nonsignificant	—	0.00	Other	0	0
509	MONO.CD16.patrolling	0.06	Nonsignificant	1.00	0.12	Other	797	216
510	EPI.colonocyte.crypt_progenitor	0.06	Nonsignificant	1.00	0.54	Other	115	265
511	HEP.pericentral_lipoprotein.UPR_redox	0.06	Nonsignificant	—	0.67	Other	0	0
512	EC.lymphatic.scavenger	0.06	Nonsignificant	1.00	0.34	Other	203	257
513	HEP.pericentral_lipoprotein.ApoB_coagulation	0.06	Nonsignificant	—	0.00	Other	0	0
514	HEP.acute_phase.hypoxia_lipid	0.05	Nonsignificant	—	0.00	Other	0	0
515	HEP.canalicular_transport.pericentral_like_hypoxia	0.05	Nonsignificant	0.38	1.15	Other	326	8
516	EPI.colonic_tuft.activated	0.05	Nonsignificant	—	0.73	Other	0	0
517	MAC.kupffer.inflammatory	0.05	Nonsignificant	—	0.46	Other	7	4
518	FIB.skin_sheath.ECM_immune	0.05	Nonsignificant	—	0.35	Other	0	0
519	IPSC.neural_primed	0.05	Nonsignificant	1.00	0.88	Other	0	0
520	EPI.alveolar_type_2.stress_response	0.05	Nonsignificant	0.96	0.87	Other	675	1,562
521	PC.IgA_muocsal.plasmablast	0.05	Nonsignificant	0.96	0.54	Other	5	4
522	EPI.cervical_suprabasal.inflammatory_repair	0.05	Nonsignificant	—	0.73	Other	0	0
523	IPSC.midbrain_primed	0.05	Nonsignificant	1.00	0.86	Other	0	0
524	IPSC.proliferative	0.04	Nonsignificant	1.00	1.00	Other	0	0
525	FIB.skin_sheath.neuro_vascular_interface	0.04	Nonsignificant	—	0.23	Other	0	0
526	EPI.colonocyte.proximal_transport	0.04	Nonsignificant	1.00	0.41	Other	24	12
527	EPI.colonic_tuft.homeostatic	0.04	Nonsignificant	—	0.00	Other	0	0
528	SCHWN.translation_boost	0.04	Nonsignificant	—	0.69	Other	8	1
529	HEP.canalicular_transport.baseline	0.04	Nonsignificant	0.38	1.30	Other	199	477
530	HEP.canalicular_transport.ductular_like_transition	0.04	Nonsignificant	0.38	1.13	Other	400	87
531	EPI.lung_club_secretory.ciliogenesis_axoneme	0.04	Nonsignificant	—	0.00	Other	0	0
532	EPI.pancreatic_acinar.adhesion_remodeling	0.04	Nonsignificant	0.58	1.16	Other	210	784
533	HEP.canalicular_transport.inflammatory	0.04	Nonsignificant	0.97	0.73	Other	1,335	194
534	OLG.myelinating_stress	0.04	Nonsignificant	1.00	0.54	Other	232	62
535	EPI.salivary_myoepithelial.activated	0.03	Nonsignificant	0.95	0.42	Other	85	281
536	EPI.ileal_goblet.baseline	0.03	Nonsignificant	0.95	0.99	Other	16	2
537	EPI.ileal_enterocyte_crypt.villus_transition	0.03	Nonsignificant	—	0.00	Other	7	10
538	HEP.canalicular_transport.injury_stress	0.03	Nonsignificant	0.97	0.80	Other	289	24
539	EPI.renal_distal_tubule.repair	0.03	Nonsignificant	—	0.00	Other	34	102
540	EPI.alveolar_type_2.injury_primed	0.03	Nonsignificant	0.96	0.51	Other	434	245
541	EPI.salivary_myoepithelial.baseline	0.03	Nonsignificant	0.95	0.49	Other	42	141
542	OLG.myelinating_mature	0.03	Nonsignificant	1.00	0.24	Other	363	94
543	FIB.skin_tenogenic.baseline	0.03	Nonsignificant	—	0.00	Other	0	2
544	EPI.pancreatic_acinar.quiet_dedifferentiation	0.03	Nonsignificant	0.58	1.24	Other	142	171
545	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.03	Nonsignificant	—	0.00	Other	0	0
546	PC.IgG_systemic.metabolic	0.02	Nonsignificant	1.00	0.23	Other	46	63
547	NEU.EXC_SYT2.synaptic	0.02	Nonsignificant	—	0.48	Other	0	0
548	FIB.skin_sheath.stress_chaperone	0.02	Nonsignificant	—	0.00	Other	0	0
549	SCHWN.reactive_inflammatory	0.02	Nonsignificant	—	0.57	Other	0	0
550	EPI.ileal_enterocyte_absorptive.brush_border	0.02	Nonsignificant	0.51	1.10	Other	580	1,717
551	EPI.thymic_medullary.canonical_alarmin	0.02	Nonsignificant	0.50	0.94	Other	8	17
552	MAC.microglia_like.patrolling_adhesive	0.02	Nonsignificant	—	0.00	Other	0	0
553	CM.contractile_oxphos	0.02	Nonsignificant	0.56	1.09	Other	6	19
554	EPI.thymic_medullary.hormone_xeno_barrier	0.02	Nonsignificant	—	0.00	Other	0	8
555	EPI.thymic_medullary.proliferative_APC	0.02	Nonsignificant	—	0.00	Other	0	0
556	FIB.skin_papillary.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
557	ASTRO.stress_mito	0.02	Nonsignificant	1.00	0.79	Other	47	110
558	IPSC.mesenchymal_primed	0.02	Nonsignificant	1.00	0.79	Other	0	0
559	EPI.ectocervical_granular.secretory_apocrine	0.02	Nonsignificant	—	0.32	Other	0	0
560	EPI.colonocyte.distal_absorptive	0.02	Nonsignificant	—	0.00	Other	0	0
561	EPI.ileal_bile_transport.detox_transcytosis	0.02	Nonsignificant	—	0.66	Other	0	1
562	PLAT.adhesion	0.02	Nonsignificant	—	0.48	Other	0	0
563	IPSC.axial_identity_primed	0.02	Nonsignificant	1.00	0.91	Other	0	0
564	EPI.ileal_goblet.stress_metallothionein	0.02	Nonsignificant	—	0.00	Other	4	11
565	EPI.pancreatic_acinar.metabolic_onecarbon	0.02	Nonsignificant	0.61	0.97	Other	287	328
566	EPI.ileal_goblet.inflammatory_mucin	0.01	Nonsignificant	0.95	0.18	Other	6	9
567	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	1.75	Other	1	9
568	MG.expanding	0.01	Nonsignificant	0.69	1.06	Other	2	1
569	ASTRO.synaptic_interaction	0.01	Nonsignificant	1.00	0.43	Other	76	334
570	EC.heart_remodeling.perivascular	0.01	Nonsignificant	1.00	0.83	Other	124	408
571	FIB.adventitial.PI16_matrix	0.01	Nonsignificant	0.79	1.07	Other	70	90
572	MESO.secretory_structural	0.01	Nonsignificant	—	1.13	Other	0	0
573	EPI.ileal_bile_transport.absorptive_xenobiotic	0.01	Nonsignificant	0.93	0.44	Other	11	12
574	MG.baseline	9.90e-03	Nonsignificant	0.69	1.07	Other	16	5
575	EC.heart_remodeling.capillary_metabolic	9.77e-03	Nonsignificant	1.00	0.57	Other	54	414
576	MAC.kupffer.fibrogenic	9.52e-03	Nonsignificant	—	0.33	Other	0	0
577	EPI.pancreatic_acinar.inflammatory_regenerative	8.78e-03	Nonsignificant	0.61	1.05	Other	25	113
578	ASTRO.A2_reactive	8.37e-03	Nonsignificant	1.00	0.45	Other	10	37
579	EPI.pancreatic_acinar.baseline	7.51e-03	Nonsignificant	1.00	0.42	Other	274	163
580	PLAT.megakaryocytic	7.29e-03	Nonsignificant	—	0.00	Other	0	0
581	ADIPO.immature	6.64e-03	Nonsignificant	—	0.00	Other	24	40
582	EPI.renal_distal_tubule.ion_transport	6.38e-03	Nonsignificant	—	0.86	Other	0	0
583	EPI.colonocyte.ionocyte_BEST4	6.09e-03	Nonsignificant	1.00	0.00	Other	103	188
584	MAC.kupffer.tolerogenic	5.68e-03	Nonsignificant	—	0.13	Other	45	49
585	MAC.kupffer.stress	4.84e-03	Nonsignificant	0.78	0.82	Other	9	3
586	EPI.ectocervical_granular.inflammatory	4.40e-03	Nonsignificant	—	0.00	Other	0	0
587	MESO.activated_stress	4.10e-03	Nonsignificant	—	0.48	Other	0	0
588	NEU.EXC_IT.structural	3.86e-03	Nonsignificant	0.50	1.16	Other	171	41
589	EC.liver_sinusoidal.hypoxia_metabolic	3.57e-03	Nonsignificant	1.00	0.25	Other	183	107
590	ASTRO.homeostatic	3.14e-03	Nonsignificant	1.00	0.32	Other	200	431
591	IPSC.endoderm_primed	3.13e-03	Nonsignificant	1.00	0.68	Other	0	0
592	CHOND.pro_inflammatory	2.60e-03	Nonsignificant	0.08	1.19	Other	181	351
593	FIB.adventitial.adhesion_lipid	2.45e-03	Nonsignificant	0.99	1.03	Other	58	209
594	FIB.adventitial.activated_remodelling	2.44e-03	Nonsignificant	—	6.42e-03	Other	141	319
595	SCHWN.axon_contact_cardiac	2.17e-03	Nonsignificant	0.99	0.24	Other	18	63
596	EPI.salivary_serous_acinar.quiescent	1.91e-03	Nonsignificant	1.00	0.00	Other	178	493
597	OPC.premyelinating	1.84e-03	Nonsignificant	0.12	1.14	Other	185	12
598	CHOND.remodeling	1.76e-03	Nonsignificant	—	0.46	Other	5	0
599	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.74e-03	Nonsignificant	—	0.00	Other	0	0
600	MG.phagocytic_APC	1.66e-03	Nonsignificant	0.92	0.80	Other	25	8
601	PERI.cardiac_skeletal	1.61e-03	Nonsignificant	1.00	0.00	Other	313	630
602	EC.heart_remodeling.remodeling_stalk	1.51e-03	Nonsignificant	1.00	0.34	Other	33	111
603	OPC.proliferative_immune_interact	1.18e-03	Nonsignificant	0.45	1.06	Other	180	373
604	GRANU.neutrophil.antiviral_endotoxin	9.31e-04	Nonsignificant	—	0.26	Other	0	0
605	EPI.endocervical_secretory.squamous_barrier	9.26e-04	Nonsignificant	—	0.67	Other	0	0
606	NEU.INH_VIP.develop_niche	8.85e-04	Nonsignificant	—	1.08	Other	0	0
607	MESO.baseline	8.83e-04	Nonsignificant	0.65	0.98	Other	0	6
608	EPI.pancreatic_islet.alpha	7.28e-04	Nonsignificant	—	0.00	Other	152	330
609	CHOND.angiogenic	6.58e-04	Nonsignificant	—	0.65	Other	0	0
610	NEU.INH_VIP.enkephalinergic	6.57e-04	Nonsignificant	—	0.95	Other	0	0
611	FIB.adventitial.inflammatory_activated	5.79e-04	Nonsignificant	0.99	1.00	Other	100	473
612	GRANU.neutrophil.primed_degranulation	5.51e-04	Nonsignificant	—	0.38	Other	0	0
613	MESO.antiviral	4.92e-04	Nonsignificant	—	0.22	Other	3	8
614	CM.baseline	4.83e-04	Nonsignificant	1.00	0.99	Other	393	0
615	CHOND.articular_collagen	4.62e-04	Nonsignificant	1.00	0.91	Other	551	266
616	IPSC.stromal_primed	3.95e-04	Nonsignificant	1.00	0.57	Other	0	0
617	NEU.INH_VIP.serotonergic	3.84e-04	Nonsignificant	—	0.41	Other	9	2
618	CM.osmoprotection	2.49e-04	Nonsignificant	1.00	1.03	Other	34	57
619	NEU.INH_PVALB.chandelier	2.17e-04	Nonsignificant	0.39	1.20	Other	19	16
620	CHOND.activated_fibro_like	1.99e-04	Nonsignificant	1.00	0.63	Other	531	188
621	MAC.resident_cardiac.inflammatory_reparative	1.58e-04	Nonsignificant	0.12	1.27	Other	31	96
622	EPI.renal_distal_tubule.stress	1.44e-04	Nonsignificant	—	0.00	Other	0	0
623	FIB.adventitial.complement_angiocrine	1.37e-04	Nonsignificant	0.99	0.82	Other	153	684
624	MAC.resident_cardiac.phagocytic_homeostasis	1.35e-04	Nonsignificant	0.56	1.04	Other	564	1,221
625	EPI.endocervical_secretory.secretory_translocon	1.18e-04	Nonsignificant	—	0.00	Other	0	0
626	NEU.INH_VIP.nuclear_reg	9.47e-05	Nonsignificant	—	0.47	Other	20	4
627	OPC.homeostatic	7.76e-05	Nonsignificant	0.97	0.84	Other	394	160
628	FIB.adventitial.baseline	6.60e-05	Nonsignificant	0.99	0.82	Other	157	278
629	FIB.adventitial.mechano_chemo_sensing	4.57e-05	Nonsignificant	0.99	0.80	Other	135	524
630	NEU.INH_PVALB.metabotropic	4.10e-05	Nonsignificant	—	0.52	Other	0	0
631	NEU.INH_VIP.matrix	3.96e-05	Nonsignificant	—	0.07	Other	24	77
632	EC.liver_sinusoidal.remodeling_lipotoxicity	3.88e-05	Nonsignificant	—	0.00	Other	90	58
633	EPI.thymic_cortical.secretory_remodeling	2.96e-05	Nonsignificant	—	0.78	Other	4	1
634	NEU.INH_VIP.regulatory_remodeling	2.83e-05	Nonsignificant	—	0.00	Other	6	1
635	EPI.ectocervical_granular.immune_interact	2.78e-05	Nonsignificant	—	0.00	Other	0	0
636	CM.sarcomere_actin_interface	2.60e-05	Nonsignificant	1.00	0.98	Other	450	78
637	IPSC.mesodermal_primed	2.34e-05	Nonsignificant	1.00	0.53	Other	0	0
638	NEU.INH_PVALB.fastspike	2.18e-05	Nonsignificant	—	0.00	Other	24	22
639	MAC.resident_cardiac.antigen_presenting	1.88e-05	Nonsignificant	0.81	0.88	Other	52	27
640	EPI.renal_distal_tubule.ciliated_remodelling	1.64e-05	Nonsignificant	—	0.00	Other	0	0
641	NEU.INH_VIP.excitatory_coupled	1.52e-05	Nonsignificant	—	0.00	Other	13	0
642	EPI.renal_distal_tubule.immune_modulatory	1.20e-05	Nonsignificant	—	0.00	Other	0	0
643	FIB.adventitial.mito_secretory	1.11e-05	Nonsignificant	0.99	0.75	Other	21	7
644	NEU.INH_LAMP5.exc_inh_balance	9.38e-06	Nonsignificant	—	0.74	Other	46	2
645	NEU.EXC_NTNG1.synaptic	7.77e-06	Nonsignificant	—	0.67	Other	0	0
646	CM.inflammatory	7.55e-06	Nonsignificant	—	1.37	Other	0	0
647	SKM.type_2_fast.oxidative_IIa	6.96e-06	Nonsignificant	0.05	1.07	Other	946	56
648	MAC.kupffer.metabolic	5.69e-06	Nonsignificant	—	0.00	Other	25	36
649	GRANU.neutrophil.tissue_patrolling	4.79e-06	Nonsignificant	—	0.00	Other	0	0
650	MESO.activated_migratory	4.78e-06	Nonsignificant	—	0.00	Other	0	0
651	NEU.INH_VIP.canonical_disinhibitory	4.54e-06	Nonsignificant	0.96	0.49	Other	59	38
652	CM.oxidative_phospho	2.77e-06	Nonsignificant	1.00	0.98	Other	266	792
653	NEU.INH_PVALB.nuclear_reg	2.65e-06	Nonsignificant	0.96	0.52	Other	25	12
654	CM.mito_proteostasis	2.50e-06	Nonsignificant	1.00	0.98	Other	329	29
655	NEU.INH_LAMP5.rosehip	2.23e-06	Nonsignificant	—	0.00	Other	0	0
656	NEU.EXC_NTNG1.nuclear_reg	2.04e-06	Nonsignificant	—	0.00	Other	0	0
657	NEU.EXC_CT.projector	2.00e-06	Nonsignificant	0.20	1.17	Other	87	26
658	NEU.INH_VIP.opioid	1.85e-06	Nonsignificant	—	0.00	Other	50	9
659	NEU.EXC_IT.transitional	1.19e-06	Nonsignificant	0.97	0.99	Other	237	142
660	NEU.INH_PVALB.serotonergic	1.15e-06	Nonsignificant	—	0.00	Other	0	0
661	EPI.lung_multiciliated.mature_motile_cilia	1.15e-06	Nonsignificant	—	1.53	Other	0	0
662	NEU.EXC_IT.callosal	1.14e-06	Nonsignificant	0.97	0.95	Other	286	119
663	IPSC.mesendo_primed	1.00e-06	Nonsignificant	1.00	0.39	Other	0	0
664	NEU.EXC_IT.neuromodulated	6.79e-07	Nonsignificant	0.97	0.86	Other	176	116
665	NEU.INH_VIP.cannabinoid	5.95e-07	Nonsignificant	—	0.00	Other	0	0
666	NEU.EXC_CT.remodeling	4.93e-07	Nonsignificant	—	0.53	Other	23	1
667	CM.mechano_activated	3.56e-07	Nonsignificant	1.00	0.98	Other	205	134
668	NEU.INH_LAMP5.projecting	3.22e-07	Nonsignificant	—	0.00	Other	0	0
669	EPI.cervical_suprabasal.secretory_vesicle	2.01e-07	Nonsignificant	—	0.00	Other	0	0
670	NEU.EXC_IT.adhesion	1.96e-07	Nonsignificant	0.97	0.89	Other	252	108
671	NEU.INH_LAMP5.glial_interface	1.86e-07	Nonsignificant	—	0.00	Other	0	0
672	CM.translation_boost_RPL	1.08e-07	Nonsignificant	1.00	0.94	Other	129	1
673	SKM.type_2_fast.glycolytic_IIx_IIb	7.19e-08	Nonsignificant	0.51	0.98	Other	565	1,482
674	EPI.lung_multiciliated.stress	3.60e-08	Nonsignificant	—	0.00	Other	67	165
675	NEU.EXC_IT.guidance	3.22e-08	Nonsignificant	1.00	0.52	Other	274	63
676	EPI.lung_multiciliated.baseline	2.22e-08	Nonsignificant	—	0.05	Other	0	7
677	NEU.INH_PVALB.neuromodulatory	9.74e-09	Nonsignificant	—	0.00	Other	0	0
678	CM.anti_inflammatory	8.40e-10	Nonsignificant	1.00	0.84	Other	424	1,503
679	SKM.type_1_slow.glycolytic	1.99e-11	Nonsignificant	0.22	1.10	Other	362	647
680	ADIPO.inflammatory	1.02e-11	Nonsignificant	—	0.00	Other	0	0
681	CM.translation_boost_RPS	4.71e-12	Nonsignificant	1.00	0.83	Other	69	16
682	NEU.EXC_CT.Ca2_signaling	4.37e-12	Nonsignificant	—	0.00	Other	68	17
683	NEU.EXC_SYT2.nuclear_reg	1.67e-12	Nonsignificant	—	0.00	Other	0	0
684	NEU.EXC_CT.Ca2_sensor	8.86e-13	Nonsignificant	—	0.00	Other	0	0
685	SKM.type_1_slow.oxidative	3.90e-13	Nonsignificant	0.92	0.94	Other	802	251
686	SKM.type_1_slow.contractile	1.18e-13	Nonsignificant	0.92	0.90	Other	596	8
687	EPI.thymic_cortical.Notch_interface	9.71e-17	Nonsignificant	—	0.00	Other	82	137
688	EPI.thymic_cortical.baseline	2.32e-17	Nonsignificant	0.97	0.58	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

1 unique genes. Showing 1–1. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
	UMOD	02-Medium	0.52	4.57	G1	C2	EPI.renal_thick_ascending_limb (L1S), EPI.renal_thick_ascending_limb.canonical_salt_transporter (L2)	—	7 cells — complete matches	110	155

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.