Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000027 · All tissues

Acute pancreatitis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Pancreatitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	hepatocyte	38.26	Significant	1.65e-49	1.45	Specific	1,515	3,822
2	T_cell	11.99	Significant	1.65e-49	1.31	Specific	470	959
3	epithelial_cell	6.40	Significant	0.07	1.03	Other	24	47
4	natural_killer_cell	5.58	Significant	1.00	1.01	Other	1,204	2,052
5	thymocyte	5.30	Nominal	1.00	0.91	Other	168	512
6	melanocyte	4.10	Nominal	1.00	0.91	Other	97	309
7	innate_lymphoid_cell_2	2.79	Nonsignificant	1.00	0.80	Other	3	8
8	plasma_cell	1.29	Nonsignificant	1.00	0.85	Other	17	24
9	B_cell	0.97	Nonsignificant	1.00	0.85	Other	356	694
10	neuron	0.88	Nonsignificant	1.00	0.81	Other	330	1,328
11	platelet	0.48	Nonsignificant	—	0.08	Other	85	104
12	smooth_muscle_cell	0.24	Nonsignificant	1.00	0.71	Other	27	139
13	induced_pluripotent_stem_cell	0.14	Nonsignificant	1.00	0.67	Other	0	0
14	schwann_cell	0.11	Nonsignificant	1.00	0.68	Other	10	57
15	dendritic_cell	0.11	Nonsignificant	1.00	0.69	Other	496	724
16	mesothelial_cell	0.09	Nonsignificant	1.00	0.60	Other	6	36
17	haematopoietic_progenitor_cell	0.07	Nonsignificant	1.00	0.64	Other	262	502
18	granulocyte	0.07	Nonsignificant	1.00	0.59	Other	5	6
19	oligodendrocyte_precursor_cell	0.04	Nonsignificant	1.00	0.56	Other	461	1,454
20	fibroblast	0.03	Nonsignificant	1.00	0.53	Other	184	826
21	adipose_stem_and_progenitor_cell	0.03	Nonsignificant	1.00	0.50	Other	327	954
22	oligodendrocyte	0.03	Nonsignificant	1.00	0.53	Other	385	1,507
23	granulosa_cell	0.02	Nonsignificant	1.00	0.52	Other	293	670
24	muscle_stem_cell	0.02	Nonsignificant	1.00	0.50	Other	7	27
25	macrophage	0.02	Nonsignificant	1.00	0.49	Other	813	1,732
26	chondrocyte	0.02	Nonsignificant	1.00	0.49	Other	548	1,069
27	astrocyte	0.01	Nonsignificant	1.00	0.48	Other	256	1,203
28	endothelial_cell	0.01	Nonsignificant	1.00	0.38	Other	373	974
29	microglia	8.48e-03	Nonsignificant	1.00	0.40	Other	61	129
30	cardiomyocyte	6.37e-03	Nonsignificant	1.00	0.73	Other	533	2,045
31	adipocyte	5.75e-03	Nonsignificant	1.00	0.43	Other	33	111
32	pericyte	5.50e-03	Nonsignificant	1.00	0.31	Other	128	517
33	monocyte	2.12e-03	Nonsignificant	1.00	0.28	Other	2,176	3,871
34	skeletal_muscle_cell	2.00e-03	Nonsignificant	1.00	0.34	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar	51.77	Significant	6.29e-23	1.39	Specific	429	1,475
2	HEP.periportal_metabolic	43.85	Significant	9.24e-16	2.94	Specific	1,750	4,427
3	HEP.acute_phase	37.71	Significant	1.00	0.67	Specific	1,441	3,641
4	HEP.canalicular_transport	33.38	Significant	1.00	0.20	Specific	1,290	3,434
5	T.CD8_Tcm	18.23	Significant	6.23e-11	2.24	Specific	460	926
6	T.CD4_Tem	18.04	Significant	2.10e-13	2.25	Specific	365	697
7	T.CD4_Th17	17.99	Significant	5.67e-10	2.38	Specific	421	794
8	T.CD8_transitional	17.33	Significant	1.59e-26	2.36	Specific	497	932
9	T.CD4_Tcm	16.31	Significant	4.48e-34	2.39	Specific	494	988
10	T.CD4_cytotoxic	16.03	Significant	4.13e-05	1.89	Specific	855	1,493
11	T.MAIT	13.33	Significant	2.67e-03	1.51	Specific	469	855
12	EPI.pancreatic_ductal_mucinous	12.88	Significant	1.00	1.12	Relevant	219	430
13	T.gamma_delta	11.75	Significant	0.08	1.35	Relevant	588	1,078
14	T.CD4_transitional	11.69	Significant	0.34	1.15	Relevant	48	110
15	T.CD8_Tem	11.31	Significant	0.34	1.09	Specific	1,083	1,857
16	T.CD8_Trm	11.06	Significant	0.29	1.16	Relevant	211	346
17	EPI.salivary_serous_acinar	11.04	Significant	3.02e-03	1.16	Specific	233	531
18	T.CD4_naive	10.21	Significant	1.00	0.78	Specific	399	866
19	T.CD4_Treg	8.44	Significant	1.00	0.26	Relevant	244	511
20	T.CD8_naive	7.58	Significant	1.00	0.25	Relevant	317	708
21	T.CD4_Tfh	6.35	Significant	1.00	0.05	—	47	45
22	NEU.EXC_CT	5.87	Significant	1.49e-03	1.32	Other	362	384
23	NK.natural_killer_cell	5.58	Significant	—	—	Other	1,204	2,045
24	EPI.extrahepatic_cholangiocyte	5.31	Nominal	—	0.67	Other	37	71
25	THYMO.thymocyte	5.30	Nominal	—	—	Other	163	495
26	T.CD4_Trm	4.85	Nominal	1.00	0.01	Other	176	363
27	EPI.colonocyte	4.81	Nominal	1.00	0.94	Other	294	815
28	T.CD4_Th2	4.71	Nominal	—	0.00	Other	1	2
29	EPI.pancreatic_ductal_bicarbonate	4.59	Nominal	1.00	0.88	Other	131	548
30	EPI.hepatic_ductular_cholangiocyte	4.56	Nominal	1.00	0.86	Other	83	243
31	HEP.pericentral_lipoprotein	4.45	Nominal	—	0.00	Other	0	0
32	EPI.pancreatic_ductal_perivascular	4.14	Nominal	1.00	0.83	Other	4	30
33	MEL.melanocyte	4.10	Nominal	—	—	Other	79	242
34	EPI.salivary_mucous_acinar	3.69	Nominal	1.00	0.91	Other	639	1,189
35	EPI.ileal_enterocyte_crypt	3.37	Nominal	1.00	0.82	Other	67	113
36	ILC2.innate_lymphoid_cell_2	2.79	Nonsignificant	—	—	Other	2	0
37	NEU.EXC_SYT2	2.02	Nonsignificant	—	1.20	Other	40	77
38	EPI.pancreatic_ductal_progenitor	1.95	Nonsignificant	1.00	0.85	Other	234	873
39	B.age_associated	1.51	Nonsignificant	0.45	1.17	Other	207	350
40	EPI.tracheal_submucosal_gland	1.43	Nonsignificant	—	0.32	Other	0	0
41	PC.IgA_muocsal	1.33	Nonsignificant	0.52	1.16	Other	18	31
42	EPI.pancreatic_islet	1.24	Nonsignificant	1.00	0.83	Other	52	132
43	B.germinal_center	1.13	Nonsignificant	0.73	0.83	Other	233	655
44	EPI.colonic_tuft	1.05	Nonsignificant	—	0.28	Other	7	24
45	PC.IgG_systemic	1.02	Nonsignificant	0.70	0.86	Other	41	60
46	EPI.gastric_foveolar	1.00	Nonsignificant	—	0.27	Other	0	0
47	B.naive	0.97	Nonsignificant	0.10	1.19	Other	307	595
48	NEU.INH_VIP	0.97	Nonsignificant	0.54	1.07	Other	241	366
49	B.memory	0.94	Nonsignificant	0.66	1.00	Other	442	882
50	EPI.intrahepatic_cholangiocyte_defense	0.83	Nonsignificant	—	0.25	Other	8	13
51	FIB.skin_sheath	0.75	Nonsignificant	0.25	1.58	Other	49	118
52	PLAT.platelet	0.48	Nonsignificant	—	0.00	Other	38	53
53	EPI.intrahepatic_cholangiocyte_transport	0.47	Nonsignificant	—	0.13	Other	12	42
54	FIB.skin_neurosecretory	0.29	Nonsignificant	—	1.95	Other	0	0
55	EPI.renal_immature_ureteric_bud	0.24	Nonsignificant	1.00	0.66	Other	217	569
56	SMC.smooth_muscle_cell	0.24	Nonsignificant	—	—	Other	20	101
57	DC.mig	0.22	Nonsignificant	—	0.93	Other	89	156
58	EPI.bile_duct_cholangiocyte	0.21	Nonsignificant	1.00	0.70	Other	37	60
59	MAC.microglia_like	0.20	Nonsignificant	0.24	1.31	Other	124	179
60	EPI.salivary_intercalated_defense	0.19	Nonsignificant	1.00	0.64	Other	81	161
61	EPI.colonic_enteroendocrine	0.18	Nonsignificant	—	0.13	Other	1	1
62	FIB.perivascular_interface	0.16	Nonsignificant	0.25	1.48	Other	0	0
63	IPSC.induced_pluripotent_stem_cell	0.14	Nonsignificant	—	—	Other	0	0
64	DC.cDC2	0.13	Nonsignificant	4.45e-03	1.33	Other	1,189	1,793
65	SCHWN.schwann_cell	0.11	Nonsignificant	—	—	Other	7	33
66	NEU.EXC_IT	0.11	Nonsignificant	1.00	0.48	Other	411	192
67	GRANU.MAST	0.10	Nonsignificant	9.43e-04	1.67	Other	5	6
68	EPI.renal_intercalated_cell_type_B	0.10	Nonsignificant	—	0.10	Other	6	7
69	MAC.resident_iron	0.10	Nonsignificant	0.16	1.20	Other	16	21
70	EPI.skin_hair_follicle_companion	0.09	Nonsignificant	—	0.01	Other	8	12
71	MESO.mesothelial_cell	0.09	Nonsignificant	—	—	Other	2	18
72	HPC.haematopoietic_progenitor_cell	0.07	Nonsignificant	—	—	Other	211	370
73	EPI.renal_intercalated_cell_type_A	0.07	Nonsignificant	1.00	0.56	Other	67	142
74	FIB.skin_papillary	0.06	Nonsignificant	—	1.35	Other	0	0
75	MAC.kupffer	0.06	Nonsignificant	0.41	1.16	Other	189	530
76	EPI.ileal_enterocyte_absorptive	0.06	Nonsignificant	1.00	0.52	Other	118	338
77	EPI.ileal_goblet	0.05	Nonsignificant	1.00	0.67	Other	181	432
78	EPI.esophageal_basal	0.05	Nonsignificant	1.00	0.60	Other	4	10
79	FIB.barrier_purinergic	0.04	Nonsignificant	—	0.81	Other	1	3
80	EPI.salivary_duct_ion_transport	0.04	Nonsignificant	1.00	0.52	Other	5	11
81	OPC.oligodendrocyte_precursor_cell	0.04	Nonsignificant	—	—	Other	413	1,269
82	EPI.ileal_bile_transport	0.04	Nonsignificant	1.00	0.50	Other	61	93
83	EPI.skin_keratinocyte_progenitor	0.03	Nonsignificant	—	0.00	Other	0	3
84	ASPC.adipose_stem_and_progenitor_cell	0.03	Nonsignificant	—	—	Other	324	930
85	EPI.alveolar_type_1	0.03	Nonsignificant	1.00	0.53	Other	26	101
86	OLG.oligodendrocyte	0.03	Nonsignificant	—	—	Other	384	1,397
87	NEU.INH_PVALB	0.03	Nonsignificant	1.00	0.53	Other	193	183
88	EPI.skin_interfollicular_spinous	0.03	Nonsignificant	1.00	0.44	Other	260	563
89	FIB.adventitial	0.03	Nonsignificant	1.00	0.92	Other	268	1,447
90	EPI.salivary_duct_excretory	0.03	Nonsignificant	1.00	0.48	Other	85	180
91	FIB.lung_alveolar	0.03	Nonsignificant	—	0.78	Other	6	15
92	FIB.skin_tenogenic	0.03	Nonsignificant	—	0.67	Other	108	227
93	FIB.transitioning	0.03	Nonsignificant	1.00	1.13	Other	172	497
94	FIB.suburothelial	0.03	Nonsignificant	1.00	0.99	Other	122	432
95	EPI.skin_keratinocyte_basal	0.03	Nonsignificant	—	0.00	Other	13	26
96	GRNLSA.granulosa_cell	0.02	Nonsignificant	—	—	Other	257	0
97	MUSC.muscle_stem_cell	0.02	Nonsignificant	—	—	Other	4	18
98	EPI.skin_sebaceous_duct_luminal	0.02	Nonsignificant	1.00	0.41	Other	100	249
99	EC.arterial	0.02	Nonsignificant	0.08	1.13	Other	356	885
100	MAC.MDM	0.02	Nonsignificant	1.00	0.98	Other	623	986
101	FIB.interstitial	0.02	Nonsignificant	1.00	0.68	Other	288	940
102	EPI.lung_club_secretory	0.02	Nonsignificant	1.00	0.58	Other	5	14
103	FIB.barrier_secretory	0.02	Nonsignificant	1.00	0.86	Other	81	228
104	FIB.reticular	0.02	Nonsignificant	1.00	0.79	Other	19	87
105	FIB.hepatic_stellate_cell	0.02	Nonsignificant	—	0.47	Other	64	252
106	CHOND.chondrocyte	0.02	Nonsignificant	—	—	Other	519	730
107	FIB.tracheal_subepithelial	0.01	Nonsignificant	—	0.35	Other	0	0
108	EC.venous	0.01	Nonsignificant	0.21	1.09	Other	516	1,387
109	EC.liver_sinusoidal	0.01	Nonsignificant	0.60	1.10	Other	1,083	1,925
110	DC.cDC1	0.01	Nonsignificant	1.00	0.57	Other	55	112
111	EPI.esophageal_suprabasal	0.01	Nonsignificant	1.00	0.33	Other	158	404
112	EPI.endocervical_secretory	0.01	Nonsignificant	—	0.00	Other	0	0
113	ASTRO.astrocyte	0.01	Nonsignificant	—	—	Other	228	1,111
114	EPI.skin_follicular_keratinizing	0.01	Nonsignificant	1.00	0.34	Other	30	81
115	EPI.skin_hair_follicle_bulge	0.01	Nonsignificant	1.00	0.33	Other	51	178
116	EPI.renal_thick_ascending_limb	0.01	Nonsignificant	1.00	0.24	Other	453	1,153
117	MAC.resident_repair	9.46e-03	Nonsignificant	1.00	0.84	Other	796	1,426
118	GRANU.neutrophil	9.06e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
119	EPI.ectocervical_granular	8.92e-03	Nonsignificant	—	0.00	Other	11	23
120	EPI.alveolar_type_2	8.75e-03	Nonsignificant	1.00	0.51	Other	813	1,853
121	FIB.neurolectin_mucosa	8.56e-03	Nonsignificant	1.00	0.63	Other	133	394
122	MG.microglia	8.48e-03	Nonsignificant	—	—	Other	49	0
123	EPI.tracheal_suprabasal	7.48e-03	Nonsignificant	1.00	0.26	Other	29	56
124	EPI.renal_distal_tubule	6.98e-03	Nonsignificant	1.00	0.35	Other	133	361
125	EC.lymphatic	6.86e-03	Nonsignificant	1.00	0.80	Other	630	998
126	EPI.thymic_medullary	6.84e-03	Nonsignificant	1.00	0.29	Other	26	133
127	CM.cardiomyocyte	6.37e-03	Nonsignificant	—	—	Other	524	2,032
128	ADIPO.adipocyte	5.75e-03	Nonsignificant	—	—	Other	20	62
129	EC.capillary	5.61e-03	Nonsignificant	1.00	0.90	Other	514	1,635
130	EPI.skin_sweat_duct_keratinocyte	5.60e-03	Nonsignificant	1.00	0.28	Other	146	301
131	PERI.pericyte	5.50e-03	Nonsignificant	—	—	Other	117	0
132	MAC.LAM	5.12e-03	Nonsignificant	1.00	0.72	Other	914	2,064
133	NEU.INH_LAMP5	5.02e-03	Nonsignificant	1.00	0.44	Other	263	532
134	EPI.renal_principal_cell	4.59e-03	Nonsignificant	1.00	0.19	Other	207	403
135	SKM.type_1_slow	4.55e-03	Nonsignificant	1.18e-06	1.17	Other	923	2,478
136	EPI.renal_proximal_tubule	3.78e-03	Nonsignificant	1.00	0.26	Other	525	806
137	EPI.tracheal_basal	3.77e-03	Nonsignificant	1.00	0.18	Other	398	1,120
138	EPI.salivary_myoepithelial	3.76e-03	Nonsignificant	1.00	0.14	Other	191	714
139	DC.pDC	2.40e-03	Nonsignificant	1.00	0.41	Other	496	1,028
140	MONO.CD14	2.31e-03	Nonsignificant	0.43	1.02	Other	2,294	4,139
141	EC.heart_remodeling	2.30e-03	Nonsignificant	1.00	0.54	Other	569	1,594
142	EPI.skin_appendage_keratinocyte	2.24e-03	Nonsignificant	1.00	0.10	Other	87	222
143	MAC.resident_cardiac	2.11e-03	Nonsignificant	1.00	0.56	Other	485	1,074
144	EPI.thymic_cortical	2.08e-03	Nonsignificant	1.00	0.57	Other	442	824
145	EPI.skin_keratinocyte_proliferating	1.83e-03	Nonsignificant	1.00	0.09	Other	47	76
146	EPI.lung_multiciliated	1.75e-03	Nonsignificant	1.00	0.10	Other	16	49
147	MAC.proliferating	1.41e-03	Nonsignificant	1.00	0.53	Other	87	253
148	EPI.cervical_suprabasal	1.25e-03	Nonsignificant	—	0.00	Other	14	50
149	MONO.CD16	1.13e-03	Nonsignificant	0.78	0.94	Other	1,304	1,835
150	NEU.EXC_NTNG1	3.90e-04	Nonsignificant	—	0.00	Other	0	0
151	SKM.type_2_fast	1.01e-04	Nonsignificant	1.00	0.81	Other	972	2,639
152	MAC.alveolar	4.47e-05	Nonsignificant	1.00	0.06	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar.adhesion_remodeling	71.70	Significant	1.16e-03	2.45	Specific	210	784
2	EPI.pancreatic_acinar.metabolic_onecarbon	57.57	Significant	0.20	1.57	—	287	328
3	HEP.periportal_metabolic.urea_onecarbon_secretory	52.78	Significant	5.72e-04	2.25	Specific	1,332	3,053
4	EPI.pancreatic_acinar.baseline	50.07	Significant	0.95	0.76	—	274	163
5	HEP.periportal_metabolic.canonical_urea_cycle	47.91	Significant	0.39	1.39	—	1,464	269
6	EPI.pancreatic_acinar.stress	45.38	Significant	0.95	0.63	—	28	28
7	HEP.periportal_metabolic.acute_phase_barrier	43.03	Significant	0.92	0.70	—	533	138
8	HEP.acute_phase.hypoxia_lipid	42.47	Significant	—	0.60	Relevant	0	0
9	HEP.acute_phase.complement_metabolic	42.28	Significant	6.49e-03	2.20	Specific	1,423	3,464
10	HEP.periportal_metabolic.xenobiotic_detox	40.55	Significant	0.92	0.61	—	1,440	139
11	HEP.canalicular_transport.baseline	40.54	Significant	0.05	2.06	Specific	199	477
12	EPI.pancreatic_acinar.inflammatory_regenerative	39.69	Significant	0.95	0.71	Relevant	25	113
13	HEP.periportal_metabolic.inflammatory_activated	38.96	Significant	0.92	0.49	Specific	712	1,610
14	EPI.pancreatic_acinar.quiet_dedifferentiation	38.26	Significant	0.97	0.27	—	142	171
15	HEP.acute_phase.baseline	37.89	Significant	0.98	0.80	—	946	19
16	HEP.canalicular_transport.secretory_ERAD_UPR	36.89	Significant	0.05	2.01	—	232	28
17	HEP.periportal_metabolic.apolipoprotein_secretory	35.16	Significant	0.92	0.55	Relevant	43	110
18	HEP.canalicular_transport.inflammatory	34.81	Significant	0.07	1.64	—	1,335	194
19	HEP.acute_phase.proliferative	34.48	Significant	—	0.00	Relevant	4	6
20	HEP.acute_phase.complement_antiviral	34.15	Significant	0.98	0.56	Specific	377	751
21	HEP.periportal_metabolic.stress_checkpoint	34.11	Significant	0.92	0.55	Relevant	234	786
22	HEP.canalicular_transport.ductular_like_transition	34.02	Significant	0.71	0.99	—	400	87
23	HEP.acute_phase.inflammatory	32.70	Significant	0.98	0.19	Specific	382	649
24	HEP.canalicular_transport.pericentral_like_hypoxia	31.16	Significant	1.00	0.46	—	326	8
25	HEP.periportal_metabolic.stress_chaperone	30.74	Significant	—	0.00	Relevant	66	128
26	HEP.canalicular_transport.injury_stress	28.50	Significant	1.00	0.02	—	289	24
27	HEP.acute_phase.stress_secretory	26.76	Significant	0.98	0.10	—	26	3
28	T.CD8_transitional.APC_like	22.15	Significant	2.91e-03	1.73	—	205	62
29	T.CD4_Th17.cytotoxic	21.67	Significant	5.32e-05	2.35	—	332	123
30	HEP.canalicular_transport.sterol_lipid_biosynthesis	21.63	Significant	—	0.00	Relevant	10	20
31	T.CD8_Tcm.effector_bias	21.58	Significant	1.05e-03	2.34	Specific	199	329
32	T.CD8_Tcm.gut_homing	21.17	Significant	0.46	1.36	—	380	112
33	T.CD4_cytotoxic.precursor	20.95	Significant	0.05	2.16	—	156	67
34	T.CD4_Tcm.Th2_like	20.76	Significant	0.23	1.65	Relevant	23	55
35	T.CD4_Tcm.synapse_dynamics	19.61	Significant	0.23	1.55	—	15	10
36	T.CD4_Tem.long_term_memory	19.45	Significant	0.19	1.55	Relevant	314	587
37	EPI.salivary_serous_acinar.seromucous_like	18.70	Significant	—	1.68	Relevant	0	0
38	T.CD8_Tcm.helper_like	18.50	Significant	0.72	1.04	Relevant	81	159
39	T.CD4_Tem.cytotoxic_effector	18.34	Significant	0.74	1.05	Relevant	225	398
40	T.CD8_transitional.Trm_primed	18.24	Significant	0.28	1.27	—	108	15
41	T.CD4_Tcm.DC_interact	18.12	Significant	0.23	1.50	—	72	32
42	T.CD4_Tcm.secretory	17.88	Significant	0.88	1.11	—	20	11
43	T.CD4_Tcm.effector_like	17.73	Significant	0.11	1.76	Relevant	293	533
44	T.CD8_Tcm.baseline	17.18	Significant	0.98	0.67	—	90	89
45	T.CD4_Tem.inflammatory	17.07	Significant	0.74	0.78	—	28	6
46	T.CD4_Tcm.tissue_homing	17.06	Significant	0.68	1.23	—	78	46
47	T.CD4_Tem.transitional_CM	16.91	Significant	0.74	0.81	—	31	20
48	T.CD4_Th17.baseline	16.90	Significant	0.91	0.58	—	51	5
49	T.MAIT.stress	16.50	Significant	—	1.01	—	0	0
50	T.CD8_transitional.early	16.43	Significant	0.90	0.90	—	327	55
51	T.CD4_Th17.migratory	16.34	Significant	0.91	0.75	Relevant	13	23
52	T.CD4_Tcm.retro_ZNF117	16.27	Significant	0.98	0.59	Relevant	5	9
53	T.CD4_Tcm.RNA_control	16.12	Significant	0.98	0.89	—	96	4
54	T.CD4_Tcm.crosstalk_myeloid	15.86	Significant	0.68	1.26	—	5	4
55	T.gamma_delta.central_memory	15.82	Significant	2.95e-03	1.87	Specific	460	919
56	T.CD4_cytotoxic.NK_adapted	15.80	Significant	0.35	1.49	—	82	33
57	T.CD4_Tcm.Tfh_like	15.66	Significant	0.98	0.75	Relevant	102	214
58	T.CD4_cytotoxic.activated	15.57	Significant	0.66	0.93	Relevant	3	1
59	T.MAIT.cytotoxic	15.41	Significant	0.82	1.21	—	52	15
60	T.CD4_cytotoxic.baseline	15.41	Significant	0.64	1.12	—	0	0
61	T.CD4_Tcm.baseline	15.38	Significant	0.98	0.70	—	61	31
62	T.CD4_Tcm.migratory_cilium	15.05	Significant	0.98	0.91	—	5	10
63	T.CD4_cytotoxic.terminal_effector	14.96	Significant	0.66	0.81	—	286	21
64	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	14.80	Significant	—	0.32	Relevant	0	0
65	T.CD4_Tcm.APC_mimicry	14.79	Significant	0.98	0.53	—	54	43
66	T.CD8_Trm.cytotoxic	14.78	Significant	3.50e-03	1.72	—	165	85
67	T.CD8_transitional.effector_primed	14.18	Significant	0.95	0.65	—	435	151
68	T.MAIT.MAPK_brake	14.14	Significant	0.82	1.16	Relevant	44	66
69	T.CD4_Tcm.imprinted_splicing	13.83	Significant	0.98	0.57	Relevant	6	17
70	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	13.82	Significant	0.08	1.85	Relevant	449	1,034
71	T.MAIT.quiescent	13.68	Significant	0.82	0.84	—	100	5
72	T.CD4_transitional.baseline	13.45	Significant	0.73	1.17	Relevant	59	97
73	T.MAIT.vesicle	13.11	Significant	0.82	0.78	Relevant	37	65
74	T.MAIT.early_activation	13.10	Significant	0.82	0.89	—	57	4
75	T.CD4_transitional.primed_cytotoxic	13.01	Significant	0.73	1.19	—	28	30
76	T.CD4_Tcm.regulatory_poised	12.77	Significant	0.98	0.75	—	2	3
77	T.CD8_Tem.stress_adapted	12.70	Significant	4.64e-03	1.97	—	607	520
78	T.CD8_Tem.motility_primed	12.64	Significant	0.36	1.45	—	269	4
79	T.CD8_naive.mito_proteostasis	12.53	Significant	2.96e-04	2.47	—	428	100
80	T.CD4_Treg.central_naive_like	12.36	Significant	6.33e-05	2.39	—	333	45
81	T.CD4_Tcm.stress	12.29	Significant	0.98	0.31	Relevant	5	11
82	T.CD4_naive.purinergic	11.97	Significant	0.50	1.39	—	49	1
83	EPI.colonocyte.secretory_boost	11.87	Significant	1.09e-05	2.44	Specific	98	91
84	EPI.salivary_serous_acinar.secretory_active	11.78	Significant	1.61e-04	2.34	—	242	69
85	T.CD8_Tem.early_helper_like	11.74	Significant	0.62	1.11	Relevant	445	755
86	T.CD4_naive.survival_mitoprot	11.48	Significant	0.03	2.05	—	13	7
87	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	11.25	Significant	—	0.00	—	0	0
88	T.CD8_Tem.baseline	11.17	Significant	0.62	1.06	—	458	356
89	T.CD4_naive.survival_neddylation	11.15	Significant	0.55	1.31	Relevant	26	38
90	T.CD4_naive.resist_bystander	10.78	Significant	0.32	1.55	—	40	25
91	T.CD8_Trm.inflammatory	10.69	Significant	0.99	0.98	Relevant	124	176
92	T.gamma_delta.early_effector	10.63	Significant	0.99	0.77	—	89	0
93	T.CD4_naive.Treg_like	10.62	Significant	0.81	1.11	—	121	72
94	T.CD4_naive.mature_mitoprot	10.58	Significant	0.61	1.16	Relevant	212	476
95	T.CD8_Trm.muscosal_Tc17	10.55	Significant	0.99	0.90	Relevant	19	38
96	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	10.47	Significant	—	0.00	—	0	0
97	T.CD4_naive.homeostatic	10.45	Significant	0.50	1.31	—	215	108
98	T.CD8_Tem.signaling_turnover	10.37	Significant	0.65	0.95	Relevant	425	683
99	T.CD4_naive.neddylation	10.37	Significant	1.00	0.84	Relevant	104	222
100	T.CD4_naive.proteostasis_mitoprot	10.35	Significant	1.00	0.82	Relevant	15	37
101	NEU.EXC_CT.Ca2_signaling	10.26	Significant	—	1.25	Relevant	68	17
102	T.CD4_naive.survival	10.18	Significant	0.90	0.99	Relevant	12	17
103	T.MAIT.migratory	10.14	Significant	1.00	0.07	—	10	1
104	T.CD4_naive.neddylation_mitoprot	9.93	Significant	1.00	0.71	—	93	56
105	T.CD4_naive.mature	9.75	Significant	1.00	0.54	—	211	100
106	T.CD4_transitional.primed_helper_effector	9.60	Significant	0.81	1.01	Relevant	19	43
107	T.CD4_naive.proteostasis	9.45	Significant	1.00	0.51	—	14	9
108	T.CD8_Trm.homeostatic	9.27	Significant	0.99	0.56	—	42	5
109	T.CD4_Treg.Tr1_like	9.21	Significant	—	0.20	—	8	8
110	T.CD8_Tem.TEMRA	9.09	Significant	1.00	0.20	—	920	1,088
111	NK.adaptive_terminal_cytotoxic	9.05	Significant	4.11e-05	2.24	Specific	485	802
112	T.gamma_delta.cytotoxic_effector	8.75	Significant	0.99	0.39	—	349	109
113	T.CD4_Trm.helper_like	8.55	Significant	5.42e-03	1.78	Specific	84	147
114	T.CD4_transitional.APC_interacting	8.46	Significant	1.00	0.48	—	10	14
115	THYMO.CD8aa_IELp	8.37	Significant	—	0.97	Relevant	1	7
116	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	8.25	Significant	—	0.43	Relevant	0	0
117	THYMO.SP_CD8_naive	8.20	Significant	4.47e-13	2.51	Specific	297	177
118	T.CD8_Tcm.NK_like	8.18	Significant	1.00	0.05	Relevant	334	581
119	NK.adaptive_axis_baseline	8.15	Significant	1.14e-10	2.61	Specific	1,008	153
120	T.CD4_naive.gut_prone	8.12	Significant	1.00	0.32	—	35	70
121	EPI.extrahepatic_cholangiocyte.mucin_secretory	8.08	Significant	—	0.73	Relevant	0	0
122	T.CD8_naive.vesicle_secretory	8.07	Significant	0.82	1.18	—	42	0
123	NK.adaptive_immature_precursor	8.06	Significant	2.39e-05	2.33	Specific	358	111
124	T.CD4_Tfh.effector_migratory	7.98	Significant	0.39	1.29	—	122	57
125	NK.adaptive_biosynthetic_primed	7.68	Significant	0.01	1.97	Specific	244	405
126	T.CD8_naive.baseline	7.63	Significant	0.65	1.30	—	142	2
127	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	7.57	Significant	5.84e-03	1.93	Specific	219	533
128	T.CD8_naive.nfkb_related	7.54	Significant	0.82	0.95	—	1	0
129	T.CD4_transitional.tissue_enagement	7.48	Significant	1.00	0.15	Relevant	5	11
130	T.CD8_naive.innate_like	7.26	Significant	0.82	0.94	—	10	1
131	T.CD8_naive.lipid_synthesis	7.26	Significant	0.82	0.85	—	6	4
132	NK.adaptive_HLAE_tuned	7.24	Significant	6.59e-07	2.26	Specific	1,124	189
133	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	7.22	Significant	—	0.84	Relevant	49	237
134	T.CD8_naive.effector_transition	7.16	Significant	0.98	0.50	Relevant	35	62
135	NK.adaptive_classII_inhibitory	7.15	Significant	2.39e-05	2.25	Specific	880	154
136	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	7.11	Significant	—	0.64	Relevant	5	3
137	T.CD4_Th2.precursor	7.07	Significant	—	0.48	Relevant	0	0
138	T.CD4_Treg.APC_interactive	7.03	Significant	0.98	0.46	—	118	28
139	T.CD8_naive.cytokine_dampened	6.96	Significant	0.82	1.06	—	71	4
140	T.CD8_naive.splicing_enriched	6.84	Significant	0.98	0.42	—	120	16
141	T.CD4_Tfh.precursor_migratory	6.82	Significant	0.39	1.29	—	72	27
142	NK.adaptive_adipose_stress	6.56	Significant	0.06	1.61	Relevant	374	39
143	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	6.49	Significant	0.49	1.32	Relevant	40	191
144	EPI.ileal_enterocyte_crypt.baseline	6.24	Significant	0.12	1.55	Other	11	6
145	T.CD8_Trm.dendritic_recruiter	6.05	Significant	0.99	0.20	Relevant	47	85
146	T.CD4_Treg.tissue_effector	5.94	Significant	0.98	0.22	Other	16	13
147	NEU.EXC_CT.projector	5.64	Significant	0.50	1.02	Other	87	26
148	T.CD4_Trm.cytotoxic_effector	5.55	Significant	0.97	1.08	Other	118	77
149	THYMO.DP_early	5.49	Nominal	0.41	1.24	Other	326	313
150	NK.cytokine_tissue_activation	5.36	Nominal	1.00	0.89	Other	267	450
151	T.CD8_transitional.stress	5.35	Nominal	—	0.00	Other	24	34
152	NK.cytokine_quiescent	5.25	Nominal	1.00	0.55	Other	623	1,062
153	THYMO.SP_CD8_naive_stress	5.23	Nominal	1.00	0.95	Other	1	1
154	MEL.mature_oxidative_traffic	5.21	Nominal	0.02	1.97	Other	247	285
155	NEU.EXC_CT.Ca2_sensor	5.19	Nominal	—	0.00	Other	0	0
156	EPI.colonocyte.proximal_transport	5.12	Nominal	0.52	1.32	Other	24	12
157	NK.cytokine_tissue_resident	5.01	Nominal	1.00	0.61	Other	74	82
158	HEP.pericentral_lipoprotein.UPR_redox	4.98	Nominal	—	0.67	Other	0	0
159	T.CD4_Tfh.canonical_GC_helper	4.94	Nominal	0.92	0.59	Other	1	2
160	NK.cytokine_repair_primed	4.88	Nominal	1.00	0.59	Other	266	11
161	T.CD4_Trm.baseline	4.74	Nominal	0.97	0.79	Other	31	21
162	NK.cytokine_biosynthetic_primed	4.73	Nominal	1.00	0.63	Other	360	21
163	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	4.73	Nominal	—	0.43	Other	0	0
164	EPI.colonocyte.crypt_progenitor	4.71	Nominal	0.79	1.02	Other	115	265
165	NK.cytokine_vascular_patrolling	4.70	Nominal	1.00	0.53	Other	863	94
166	MEL.stress_glucocorticoid	4.58	Nominal	0.40	1.27	Other	11	34
167	NK.cytokine_axis_baseline	4.46	Nominal	1.00	0.50	Other	1,172	116
168	EPI.hepatic_ductular_cholangiocyte.polarity	4.36	Nominal	—	0.00	Other	0	0
169	T.CD4_Tfh.suppression_exhaustion	4.22	Nominal	0.92	0.50	Other	0	2
170	EPI.pancreatic_ductal_perivascular.protective_antioxidant	4.19	Nominal	—	0.24	Other	11	69
171	EPI.pancreatic_ductal_perivascular.baseline	4.12	Nominal	0.76	0.64	Other	1	5
172	THYMO.SP_CD4_naive	4.03	Nominal	1.00	0.64	Other	65	75
173	HEP.pericentral_lipoprotein.ApoB_coagulation	3.94	Nominal	—	0.00	Other	0	0
174	EPI.pancreatic_ductal_bicarbonate.inflammatory	3.91	Nominal	0.99	0.79	Other	14	32
175	ILC2.migratory	3.76	Nominal	—	0.44	Other	0	0
176	ILC2.activated	3.76	Nominal	—	0.59	Other	0	0
177	EPI.salivary_mucous_acinar.baseline	3.69	Nominal	—	—	Other	394	683
178	T.CD4_Trm.activated	3.67	Nominal	0.97	0.85	Other	32	26
179	T.CD4_Trm.metal_stress	3.66	Nominal	0.97	0.69	Other	34	58
180	MEL.secretory_quiescent	3.61	Nominal	0.87	0.54	Other	19	13
181	T.CD4_Trm.central_like	3.59	Nominal	0.97	0.54	Other	38	31
182	EPI.colonocyte.junction_remodeling	3.50	Nominal	1.00	0.48	Other	218	305
183	NEU.EXC_CT.remodeling	3.34	Nominal	—	0.00	Other	23	1
184	EPI.ileal_enterocyte_crypt.proliferative_S	3.34	Nominal	0.95	0.85	Other	4	2
185	EPI.hepatic_ductular_cholangiocyte.stress	3.29	Nominal	—	0.00	Other	0	0
186	EPI.hepatic_ductular_cholangiocyte.secretory_transport	3.23	Nominal	—	0.00	Other	0	0
187	EPI.pancreatic_ductal_bicarbonate.baseline	3.23	Nominal	0.99	0.30	Other	11	42
188	THYMO.DP_early_stress	3.15	Nominal	—	0.00	Other	0	0
189	EPI.ileal_enterocyte_crypt.proliferative_G2M	3.11	Nominal	—	0.17	Other	19	54
190	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	2.93	Nonsignificant	—	0.00	Other	6	9
191	EPI.pancreatic_ductal_bicarbonate.activated	2.83	Nonsignificant	0.99	0.41	Other	10	7
192	MEL.dedifferentiated_migratory	2.76	Nonsignificant	—	0.00	Other	0	0
193	T.CD4_Trm.stress_adaptive	2.73	Nonsignificant	0.97	0.63	Other	8	22
194	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.68	Nonsignificant	—	1.28	Other	105	368
195	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	2.63	Nonsignificant	—	1.21	Other	0	0
196	NK.cytokine_lung_immediate_early	2.51	Nonsignificant	1.00	0.04	Other	424	274
197	EPI.pancreatic_islet.beta	2.47	Nonsignificant	3.83e-03	1.37	Other	42	57
198	NEU.EXC_SYT2.synaptic	2.46	Nonsignificant	—	0.48	Other	0	0
199	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	2.40	Nonsignificant	—	0.00	Other	0	0
200	EPI.pancreatic_ductal_bicarbonate.stress	2.37	Nonsignificant	—	0.00	Other	12	33
201	EPI.extrahepatic_cholangiocyte.barrier_interface	2.36	Nonsignificant	—	0.00	Other	0	0
202	EPI.colonocyte.goblet_interface	2.14	Nonsignificant	—	0.00	Other	11	21
203	EPI.pancreatic_ductal_progenitor.ADM_like	2.00	Nonsignificant	—	0.10	Other	0	0
204	NEU.INH_VIP.serotonergic	1.90	Nonsignificant	—	1.26	Other	9	2
205	THYMO.proliferative_S	1.90	Nonsignificant	1.00	0.10	Other	163	418
206	NK.immature_bridge	1.73	Nonsignificant	1.00	0.01	Other	117	122
207	EPI.pancreatic_ductal_progenitor.baseline	1.72	Nonsignificant	0.98	0.05	Other	179	702
208	B.germinal_center.DZ_M_phase	1.70	Nonsignificant	—	1.47	Other	0	0
209	EPI.ileal_enterocyte_crypt.secretory_precursor	1.64	Nonsignificant	—	0.00	Other	0	0
210	PC.IgG_systemic.stress	1.62	Nonsignificant	—	0.91	Other	1	5
211	NEU.INH_VIP.canonical_disinhibitory	1.60	Nonsignificant	0.14	1.35	Other	59	38
212	NEU.INH_VIP.excitatory_coupled	1.59	Nonsignificant	—	0.80	Other	13	0
213	B.age_associated.migratory	1.54	Nonsignificant	0.55	0.88	Other	2	2
214	B.age_associated.activated	1.52	Nonsignificant	—	0.00	Other	18	22
215	T.CD4_naive.activated_stress	1.51	Nonsignificant	1.00	0.00	Other	339	429
216	B.germinal_center.DZ_S_phase	1.50	Nonsignificant	—	0.58	Other	0	0
217	MEL.neurotrophic_migratory	1.48	Nonsignificant	—	0.00	Other	0	0
218	EPI.tracheal_submucosal_gland.acinar_serous	1.47	Nonsignificant	—	0.00	Other	0	0
219	B.memory.pDC_imprint	1.47	Nonsignificant	0.35	1.28	Other	157	103
220	B.age_associated.naive_transitional	1.46	Nonsignificant	—	0.00	Other	0	0
221	PC.IgA_muocsal.activated	1.44	Nonsignificant	0.84	1.05	Other	17	8
222	B.naive.remodeling	1.42	Nonsignificant	0.43	1.22	Other	135	230
223	PC.IgA_muocsal.migratory	1.41	Nonsignificant	0.84	1.16	Other	4	1
224	EPI.tracheal_submucosal_gland.ductal_luminal	1.38	Nonsignificant	—	0.00	Other	0	0
225	NEU.EXC_SYT2.nuclear_reg	1.32	Nonsignificant	—	0.00	Other	0	0
226	B.naive.receptor_recycle	1.30	Nonsignificant	0.97	0.97	Other	51	0
227	NEU.INH_VIP.opioid	1.29	Nonsignificant	—	0.41	Other	50	9
228	PC.IgG_systemic.secretory	1.26	Nonsignificant	0.57	1.16	Other	0	0
229	PLAT.megakaryocytic	1.23	Nonsignificant	—	0.97	Other	0	0
230	B.naive.baseline	1.21	Nonsignificant	0.97	0.84	Other	10	13
231	PC.IgA_muocsal.baseline	1.19	Nonsignificant	0.95	0.67	Other	3	5
232	THYMO.DN_preTCR	1.19	Nonsignificant	1.00	0.15	Other	41	71
233	PC.IgG_systemic.interacting	1.19	Nonsignificant	0.57	1.10	Other	0	0
234	B.naive.purinergic	1.16	Nonsignificant	0.82	1.04	Other	384	820
235	T.CD4_Th2.tissue_adapted	1.14	Nonsignificant	—	0.00	Other	0	0
236	B.naive.antigen_presenting_ready	1.13	Nonsignificant	0.43	1.23	Other	48	73
237	B.memory.baseline	1.12	Nonsignificant	3.86e-04	1.58	Other	472	99
238	EPI.colonic_tuft.activated	1.09	Nonsignificant	—	0.42	Other	0	0
239	IPSC.canonical_pluripotent	1.07	Nonsignificant	5.61e-16	1.26	Other	0	0
240	ILC2.quiescent	1.07	Nonsignificant	—	0.00	Other	0	0
241	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.07	Nonsignificant	—	1.15	Other	0	0
242	EPI.colonocyte.ionocyte_BEST4	1.06	Nonsignificant	1.00	0.04	Other	103	188
243	EPI.ileal_enterocyte_crypt.bile_transport	1.05	Nonsignificant	1.00	0.20	Other	2	0
244	EPI.colonic_tuft.homeostatic	1.01	Nonsignificant	—	0.00	Other	0	0
245	EPI.gastric_foveolar.baseline	1.00	Nonsignificant	—	0.00	Other	0	0
246	B.naive.proteostasis	0.97	Nonsignificant	0.61	1.15	Other	49	69
247	B.germinal_center.LZ_survival	0.96	Nonsignificant	—	0.00	Other	0	0
248	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.96	Nonsignificant	—	0.00	Other	0	0
249	B.germinal_center.LZ_memory_precursor	0.95	Nonsignificant	—	0.00	Other	0	0
250	PC.IgA_muocsal.plasmablast	0.94	Nonsignificant	0.95	0.80	Other	5	4
251	B.naive.metabolic	0.92	Nonsignificant	0.97	0.76	Other	50	79
252	THYMO.proliferative_G2M	0.92	Nonsignificant	—	0.00	Other	164	413
253	FIB.skin_sheath.ECM_immune	0.90	Nonsignificant	—	0.35	Other	0	0
254	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.89	Nonsignificant	—	0.00	Other	0	0
255	FIB.skin_sheath.stress_chaperone	0.88	Nonsignificant	—	0.00	Other	0	0
256	B.naive.activated	0.84	Nonsignificant	0.97	0.74	Other	77	127
257	B.memory.migratory	0.82	Nonsignificant	1.00	0.81	Other	123	208
258	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.79	Nonsignificant	—	0.00	Other	0	0
259	NEU.INH_VIP.regulatory_remodeling	0.78	Nonsignificant	—	0.00	Other	6	1
260	NEU.INH_VIP.enkephalinergic	0.76	Nonsignificant	—	0.04	Other	0	0
261	MAC.microglia_like.phagocytic_redox	0.68	Nonsignificant	—	0.85	Other	0	0
262	THYMO.SP_CD8_transitional	0.68	Nonsignificant	1.00	0.06	Other	32	75
263	B.germinal_center.LZ_selection	0.64	Nonsignificant	—	0.00	Other	0	0
264	FIB.adventitial.activated_remodelling	0.59	Nonsignificant	—	0.35	Other	141	319
265	B.memory.activated	0.58	Nonsignificant	1.00	0.90	Other	105	29
266	NEU.INH_VIP.nuclear_reg	0.57	Nonsignificant	—	0.00	Other	20	4
267	EPI.ileal_enterocyte_crypt.villus_transition	0.57	Nonsignificant	—	0.00	Other	7	10
268	EPI.renal_immature_ureteric_bud.defense_secretory	0.56	Nonsignificant	0.11	1.46	Other	45	76
269	SMC.contractile	0.55	Nonsignificant	8.08e-05	1.40	Other	80	588
270	CM.inflammatory	0.54	Nonsignificant	—	2.74	Other	0	0
271	EPI.ileal_goblet.immature	0.50	Nonsignificant	—	1.13	Other	0	0
272	FIB.skin_sheath.neuro_vascular_interface	0.47	Nonsignificant	—	6.94e-17	Other	0	0
273	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	0.46	Nonsignificant	—	0.32	Other	0	0
274	EPI.salivary_serous_acinar.quiescent	0.44	Nonsignificant	1.00	0.00	Other	178	493
275	EPI.bile_duct_cholangiocyte.secretory_mucin	0.41	Nonsignificant	—	0.76	Other	7	12
276	MESO.secretory_structural	0.39	Nonsignificant	—	0.77	Other	0	0
277	PC.IgG_systemic.metabolic	0.39	Nonsignificant	1.00	0.14	Other	46	63
278	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.36	Nonsignificant	0.46	1.18	Other	11	22
279	DC.cDC2.antiviral	0.35	Nonsignificant	0.02	1.35	Other	100	37
280	B.naive.restrained	0.35	Nonsignificant	0.97	0.78	Other	183	353
281	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.35	Nonsignificant	—	0.97	Other	0	0
282	NEU.EXC_IT.structural	0.34	Nonsignificant	0.53	1.14	Other	171	41
283	FIB.skin_neurosecretory.baseline	0.29	Nonsignificant	—	0.00	Other	0	0
284	B.memory.preactivated	0.27	Nonsignificant	1.00	0.42	Other	173	174
285	HPC.GMP_inflammatory	0.26	Nonsignificant	0.40	1.29	Other	20	10
286	DC.cDC2.lipid_metabolic	0.24	Nonsignificant	—	0.77	Other	0	0
287	FIB.perivascular_interface.vascular_BM_remodelling	0.24	Nonsignificant	—	0.51	Other	0	0
288	FIB.perivascular_interface.vasomotor_tone	0.22	Nonsignificant	—	0.52	Other	0	0
289	DC.mig.baseline	0.22	Nonsignificant	—	0.00	Other	1	0
290	IPSC.midbrain_primed	0.22	Nonsignificant	1.00	1.14	Other	0	0
291	MAC.kupffer.stress	0.19	Nonsignificant	0.28	1.23	Other	9	3
292	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.18	Nonsignificant	—	0.97	Other	0	0
293	NEU.INH_VIP.matrix	0.18	Nonsignificant	—	0.00	Other	24	77
294	MAC.resident_iron.stress_tolerogenic	0.18	Nonsignificant	—	0.81	Other	0	0
295	IPSC.neuroendocrine_primed	0.17	Nonsignificant	—	1.14	Other	0	0
296	GRANU.MAST.activated_acute	0.17	Nonsignificant	—	0.62	Other	0	0
297	DC.cDC2.tolerogenic_regulatory	0.16	Nonsignificant	1.00	0.97	Other	44	4
298	GRANU.MAST.resting_granule	0.15	Nonsignificant	—	0.73	Other	0	0
299	SCHWN.axon_contact_cardiac	0.14	Nonsignificant	0.15	1.45	Other	18	63
300	EPI.colonocyte.distal_absorptive	0.14	Nonsignificant	—	0.00	Other	0	0
301	EPI.skin_interfollicular_spinous.upper_lipid	0.14	Nonsignificant	—	1.79	Other	6	6
302	NEU.EXC_IT.adhesion	0.14	Nonsignificant	0.53	1.12	Other	252	108
303	EPI.renal_immature_ureteric_bud.osmoprotective	0.13	Nonsignificant	0.99	0.39	Other	126	44
304	EPI.colonic_enteroendocrine.progenitor	0.12	Nonsignificant	—	0.00	Other	0	0
305	NEU.INH_VIP.cannabinoid	0.12	Nonsignificant	—	0.00	Other	0	0
306	DC.cDC2.adhesion_signaling	0.12	Nonsignificant	1.00	0.89	Other	35	9
307	MAC.resident_iron.APC_iron_sensing	0.11	Nonsignificant	0.77	1.16	Other	211	114
308	NEU.INH_PVALB.chandelier	0.11	Nonsignificant	2.34e-04	1.33	Other	19	16
309	SCHWN.reactive_inflammatory	0.11	Nonsignificant	—	0.21	Other	0	0
310	EC.arterial.elastic	0.11	Nonsignificant	0.02	1.35	Other	22	45
311	EPI.ileal_enterocyte_absorptive.villus_tip	0.10	Nonsignificant	1.30e-04	1.67	Other	4	3
312	HPC.GMP_granulocytic	0.10	Nonsignificant	—	0.45	Other	3	3
313	EPI.renal_intercalated_cell_type_B.baseline	0.10	Nonsignificant	—	0.00	Other	3	1
314	MAC.microglia_like.inflammatory_chemokine	0.10	Nonsignificant	—	0.18	Other	20	32
315	EPI.lung_club_secretory.inflammatory	0.09	Nonsignificant	—	1.47	Other	0	0
316	MAC.resident_iron.heme_catabolism	0.09	Nonsignificant	0.88	0.87	Other	30	51
317	MESO.antiviral	0.09	Nonsignificant	—	0.48	Other	3	8
318	NEU.EXC_IT.transitional	0.08	Nonsignificant	1.00	0.96	Other	237	142
319	NEU.INH_VIP.develop_niche	0.08	Nonsignificant	—	0.00	Other	0	0
320	CM.contractile_oxphos	0.08	Nonsignificant	0.59	1.11	Other	6	19
321	DC.cDC2.pro_inflammatory	0.08	Nonsignificant	1.00	0.85	Other	3	5
322	EC.lymphatic.valve	0.08	Nonsignificant	—	2.18	Other	0	0
323	MAC.resident_iron.redox_metabolic	0.08	Nonsignificant	0.88	0.68	Other	4	4
324	GRNLSA.cholesterol_mevalonate	0.08	Nonsignificant	0.29	1.37	Other	9	4
325	EC.venous.cardiac_structural	0.08	Nonsignificant	0.64	1.28	Other	102	229
326	FIB.barrier_purinergic.lipid_secretory	0.08	Nonsignificant	—	0.48	Other	0	0
327	EPI.renal_intercalated_cell_type_A.acid_secretion	0.07	Nonsignificant	0.62	0.87	Other	12	6
328	OLG.stress	0.07	Nonsignificant	1.71e-03	1.38	Other	232	8
329	NEU.EXC_IT.neuromodulated	0.07	Nonsignificant	1.00	0.87	Other	176	116
330	SMC.metabolic	0.07	Nonsignificant	1.00	0.50	Other	14	40
331	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.07	Nonsignificant	—	0.00	Other	0	0
332	FIB.skin_papillary.baseline	0.06	Nonsignificant	—	0.00	Other	0	0
333	FIB.perivascular_interface.lipid_shuttle	0.06	Nonsignificant	—	0.00	Other	51	170
334	SCHWN.translation_boost	0.06	Nonsignificant	—	0.00	Other	8	1
335	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.06	Nonsignificant	—	0.00	Other	0	0
336	EPI.colonic_enteroendocrine.Lcell_peptide	0.06	Nonsignificant	—	0.00	Other	0	0
337	EPI.esophageal_basal.activated_progenitor	0.06	Nonsignificant	0.03	1.72	Other	1	0
338	EPI.renal_distal_tubule.ciliated_remodelling	0.06	Nonsignificant	—	1.64	Other	0	0
339	OLG.reactive_repair	0.06	Nonsignificant	0.37	1.27	Other	385	385
340	FIB.adventitial.adhesion_lipid	0.06	Nonsignificant	0.67	1.31	Other	58	209
341	MESO.activated_migratory	0.06	Nonsignificant	—	0.00	Other	0	0
342	EPI.renal_intercalated_cell_type_A.PC_transitional	0.05	Nonsignificant	—	0.00	Other	203	407
343	MAC.kupffer.monocyte_like	0.05	Nonsignificant	—	0.00	Other	0	0
344	EPI.skin_keratinocyte_basal.transit_amplifying	0.05	Nonsignificant	—	0.97	Other	0	0
345	SMC.activated	0.05	Nonsignificant	1.00	0.28	Other	2	5
346	OPC.premyelinating	0.05	Nonsignificant	0.23	1.29	Other	185	12
347	PLAT.adhesion	0.05	Nonsignificant	—	0.00	Other	0	0
348	EPI.skin_keratinocyte_progenitor.activated_stress	0.05	Nonsignificant	—	0.38	Other	0	0
349	ASPC.niche_keeping_progenitor	0.05	Nonsignificant	0.37	1.18	Other	52	219
350	ASPC.activated	0.05	Nonsignificant	0.37	1.16	Other	164	162
351	ASPC.adipocyte_capillary_interface	0.05	Nonsignificant	0.61	1.20	Other	21	54
352	ASTRO.A2_reactive	0.05	Nonsignificant	0.91	1.19	Other	10	37
353	GRANU.MAST.activated_repair	0.05	Nonsignificant	—	0.00	Other	0	1
354	EPI.pancreatic_islet.delta	0.04	Nonsignificant	—	0.00	Other	0	0
355	EPI.alveolar_type_1.activated	0.04	Nonsignificant	—	1.04	Other	0	0
356	EPI.salivary_duct_ion_transport.baseline	0.04	Nonsignificant	—	—	Other	0	0
357	ASPC.preadipocyte_lipid_primed	0.04	Nonsignificant	0.37	1.12	Other	331	129
358	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.04	Nonsignificant	—	0.69	Other	0	0
359	IPSC.mesodermal_primed	0.04	Nonsignificant	1.00	0.76	Other	0	0
360	FIB.adventitial.mechano_chemo_sensing	0.04	Nonsignificant	0.67	1.19	Other	135	524
361	CHOND.angiogenic	0.04	Nonsignificant	—	1.29	Other	0	0
362	FIB.transitioning.matrix_stress	0.04	Nonsignificant	—	0.00	Other	47	138
363	EPI.skin_keratinocyte_basal.spinous_transition	0.04	Nonsignificant	—	0.00	Other	0	0
364	OPC.proliferative_immune_interact	0.04	Nonsignificant	0.70	1.04	Other	180	373
365	ASPC.secretory	0.04	Nonsignificant	0.37	1.12	Other	76	5
366	EPI.pancreatic_islet.alpha	0.04	Nonsignificant	—	0.00	Other	152	330
367	FIB.interstitial.immune_interact	0.04	Nonsignificant	0.55	1.25	Other	12	1
368	NEU.INH_VIP.LAMP5_hybrid	0.04	Nonsignificant	—	0.00	Other	1	9
369	EPI.ileal_bile_transport.absorptive_xenobiotic	0.04	Nonsignificant	0.32	1.22	Other	11	12
370	MAC.MDM.APC_dendritic	0.04	Nonsignificant	0.89	1.06	Other	48	15
371	DC.cDC2.proliferative	0.04	Nonsignificant	—	0.00	Other	39	71
372	IPSC.endoderm_primed	0.04	Nonsignificant	1.00	0.79	Other	0	0
373	FIB.lung_alveolar.stress_interacting	0.04	Nonsignificant	—	0.97	Other	0	0
374	HPC.LMPP	0.03	Nonsignificant	0.61	1.08	Other	65	31
375	MONO.CD14.platelet_bound	0.03	Nonsignificant	0.23	1.24	Other	964	176
376	MAC.kupffer.tolerogenic	0.03	Nonsignificant	—	0.58	Other	45	49
377	EPI.skin_interfollicular_spinous.baseline	0.03	Nonsignificant	1.00	1.12	Other	35	3
378	FIB.suburothelial.inflammatory_prostanoid	0.03	Nonsignificant	—	0.49	Other	0	0
379	FIB.transitioning.ISG_primed_interface	0.03	Nonsignificant	—	0.05	Other	17	80
380	EPI.salivary_duct_excretory.stress	0.03	Nonsignificant	0.18	1.42	Other	33	68
381	EPI.alveolar_type_1.baseline	0.03	Nonsignificant	0.91	0.28	Other	8	0
382	FIB.suburothelial.contractile_myofibroblast	0.03	Nonsignificant	—	0.34	Other	9	0
383	EPI.skin_interfollicular_spinous.stress_UPR	0.03	Nonsignificant	—	0.39	Other	0	0
384	FIB.adventitial.inflammatory_activated	0.03	Nonsignificant	0.96	1.04	Other	100	473
385	FIB.barrier_secretory.remodeling	0.03	Nonsignificant	—	0.90	Other	0	0
386	MUSC.baseline	0.03	Nonsignificant	0.52	1.42	Other	0	0
387	MAC.resident_repair.lipid_phagocytic	0.03	Nonsignificant	5.02e-03	1.59	Other	228	604
388	GRNLSA.chemokine_mechanosensory	0.03	Nonsignificant	0.67	1.23	Other	1	0
389	MAC.MDM.LAM_like	0.03	Nonsignificant	0.89	1.19	Other	12	14
390	FIB.skin_tenogenic.baseline	0.03	Nonsignificant	—	0.00	Other	0	2
391	GRNLSA.lipid_hypoxia	0.03	Nonsignificant	0.94	0.98	Other	28	0
392	EPI.salivary_duct_excretory.baseline	0.03	Nonsignificant	0.77	0.77	Other	23	57
393	EC.liver_sinusoidal.prostanoid	0.03	Nonsignificant	—	0.96	Other	11	64
394	ASPC.mesothelial_like	0.03	Nonsignificant	0.66	1.17	Other	143	486
395	OLG.vesicle_trafficking	0.03	Nonsignificant	1.00	1.01	Other	124	10
396	EPI.skin_interfollicular_spinous.stress_oxidative	0.03	Nonsignificant	—	0.30	Other	0	0
397	EPI.ileal_bile_transport.detox_transcytosis	0.03	Nonsignificant	—	0.00	Other	0	1
398	HPC.CLP_B_primed	0.03	Nonsignificant	—	0.85	Other	0	0
399	OLG.regulatory	0.03	Nonsignificant	1.00	0.87	Other	353	73
400	FIB.suburothelial.urothelial_interface	0.03	Nonsignificant	0.53	1.00	Other	9	8
401	DC.cDC1.proliferative	0.03	Nonsignificant	—	0.89	Other	0	0
402	ASPC.baseline	0.03	Nonsignificant	0.98	0.90	Other	363	170
403	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.03	Nonsignificant	0.58	0.99	Other	2	9
404	OPC.homeostatic	0.03	Nonsignificant	0.92	0.68	Other	394	160
405	CHOND.pro_inflammatory	0.02	Nonsignificant	0.61	1.04	Other	181	351
406	IPSC.axial_identity_primed	0.02	Nonsignificant	1.00	0.62	Other	0	0
407	IPSC.stress	0.02	Nonsignificant	1.00	0.67	Other	0	0
408	EPI.skin_hair_follicle_companion.activated_migratory	0.02	Nonsignificant	—	0.00	Other	0	0
409	FIB.lung_alveolar.mito_secretory	0.02	Nonsignificant	—	0.00	Other	0	0
410	GRNLSA.EMT_insulin_signaling	0.02	Nonsignificant	0.94	0.91	Other	47	84
411	HPC.MPP_IEG	0.02	Nonsignificant	0.61	1.10	Other	45	46
412	EPI.ectocervical_granular.secretory_apocrine	0.02	Nonsignificant	—	1.15	Other	0	0
413	FIB.suburothelial.homeostasis_matrix	0.02	Nonsignificant	0.52	1.32	Other	258	921
414	CHOND.activated_fibro_like	0.02	Nonsignificant	0.61	1.08	Other	531	188
415	FIB.reticular.stromal_niche	0.02	Nonsignificant	0.13	1.34	Other	0	0
416	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.02	Nonsignificant	—	0.00	Other	2	0
417	EPI.renal_thick_ascending_limb.barrier_repair	0.02	Nonsignificant	0.01	1.47	Other	141	284
418	FIB.interstitial.remodeling	0.02	Nonsignificant	0.57	1.14	Other	31	9
419	EPI.skin_interfollicular_spinous.early_differentiation	0.02	Nonsignificant	1.00	0.66	Other	89	19
420	ASTRO.synaptic_interaction	0.02	Nonsignificant	0.91	1.11	Other	76	334
421	FIB.reticular.immune_interface	0.02	Nonsignificant	—	0.00	Other	1	6
422	MUSC.quiescent_reservoir	0.02	Nonsignificant	0.72	1.18	Other	2	8
423	IPSC.proliferative	0.02	Nonsignificant	1.00	0.62	Other	0	0
424	NEU.EXC_IT.callosal	0.02	Nonsignificant	1.00	0.60	Other	286	119
425	FIB.hepatic_stellate_cell.inflammatory	0.02	Nonsignificant	—	1.15	Other	0	0
426	FIB.interstitial.mesenchymal_regulator	0.02	Nonsignificant	0.55	1.25	Other	4	4
427	OLG.regulatory_activated	0.02	Nonsignificant	1.00	0.80	Other	196	614
428	EPI.skin_sweat_duct_keratinocyte.repair	0.02	Nonsignificant	—	1.24	Other	0	0
429	EPI.ectocervical_granular.inflammatory	0.02	Nonsignificant	—	0.32	Other	0	0
430	FIB.neurolectin_mucosa.remodeling_repair	0.02	Nonsignificant	—	1.08	Other	4	2
431	GRNLSA.stress_metabolic	0.02	Nonsignificant	—	0.60	Other	1	2
432	EPI.esophageal_suprabasal.differentiating_keratin	0.02	Nonsignificant	0.09	1.43	Other	131	61
433	EPI.endocervical_secretory.secretory_translocon	0.02	Nonsignificant	—	0.67	Other	0	0
434	EPI.salivary_intercalated_defense.inflammatory	0.02	Nonsignificant	0.89	0.66	Other	152	360
435	EPI.skin_follicular_keratinizing.root_infundibulum	0.02	Nonsignificant	—	0.58	Other	0	0
436	EC.arterial.homeostatic	0.02	Nonsignificant	0.95	0.98	Other	24	3
437	OLG.myelinating_mature	0.02	Nonsignificant	1.00	0.70	Other	363	94
438	OLG.myelinating_stress	0.02	Nonsignificant	1.00	0.64	Other	232	62
439	FIB.hepatic_stellate_cell.fibrogenic	0.02	Nonsignificant	—	0.00	Other	0	0
440	ASTRO.neuromodulatory	0.02	Nonsignificant	0.98	1.05	Other	34	172
441	ASPC.inflammatory	0.02	Nonsignificant	0.98	0.69	Other	21	61
442	ASPC.remodeling	0.02	Nonsignificant	0.98	0.82	Other	106	354
443	DC.cDC1.cross_presenting	0.02	Nonsignificant	—	0.52	Other	0	0
444	EPI.renal_thick_ascending_limb.salt_sensing	0.02	Nonsignificant	1.00	1.11	Other	73	103
445	MUSC.activated_migratory	0.02	Nonsignificant	0.82	0.57	Other	6	7
446	DC.cDC2.migratory	0.02	Nonsignificant	1.00	0.44	Other	185	39
447	IPSC.mesendo_primed	0.02	Nonsignificant	1.00	0.54	Other	0	0
448	EC.liver_sinusoidal.stress	0.02	Nonsignificant	—	0.24	Other	413	158
449	ASPC.proliferative	0.02	Nonsignificant	0.97	0.93	Other	33	85
450	MAC.LAM.anti_inflammatory	0.02	Nonsignificant	0.75	1.13	Other	86	132
451	EC.venous.baseline	0.02	Nonsignificant	0.64	1.04	Other	346	807
452	EPI.salivary_myoepithelial.contractile_repair	0.02	Nonsignificant	—	1.27	Other	3	9
453	FIB.tracheal_subepithelial.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
454	FIB.hepatic_stellate_cell.contractile	0.01	Nonsignificant	—	0.00	Other	0	0
455	EC.venous.activated	0.01	Nonsignificant	0.79	1.01	Other	247	752
456	DC.cDC1.activated	0.01	Nonsignificant	—	0.00	Other	0	0
457	MUSC.early_activation	0.01	Nonsignificant	0.72	0.93	Other	4	32
458	EC.capillary.inflammatory	0.01	Nonsignificant	0.35	1.20	Other	27	51
459	MAC.MDM.inflammatory_phagocytic	0.01	Nonsignificant	0.92	0.94	Other	199	52
460	NEU.INH_PVALB.metabotropic	0.01	Nonsignificant	—	0.48	Other	0	0
461	EC.liver_sinusoidal.hypoxia_metabolic	0.01	Nonsignificant	0.65	0.90	Other	183	107
462	FIB.transitioning.motility_remodelling	0.01	Nonsignificant	—	0.24	Other	0	0
463	EC.liver_sinusoidal.secretory_lipoprotein	0.01	Nonsignificant	0.65	0.81	Other	120	70
464	GRANU.neutrophil.primed_degranulation	0.01	Nonsignificant	—	0.64	Other	0	0
465	PERI.baseline	0.01	Nonsignificant	0.44	1.18	Other	39	66
466	DC.cDC1.baseline	0.01	Nonsignificant	—	0.16	Other	0	0
467	EPI.skin_sebaceous_duct_luminal.detox_repair	0.01	Nonsignificant	0.58	0.94	Other	137	94
468	FIB.adventitial.baseline	0.01	Nonsignificant	0.99	0.79	Other	157	278
469	MG.phagocytic_APC	0.01	Nonsignificant	0.45	1.19	Other	25	8
470	IPSC.mesenchymal_primed	0.01	Nonsignificant	1.00	0.55	Other	0	0
471	EPI.alveolar_type_2.injury_primed	0.01	Nonsignificant	0.56	1.09	Other	434	245
472	FIB.interstitial.lipid_matrix	0.01	Nonsignificant	1.00	0.88	Other	258	191
473	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	0.01	Nonsignificant	—	0.92	Other	0	0
474	MAC.resident_repair.antigen_presenting	0.01	Nonsignificant	0.49	1.20	Other	244	113
475	EPI.skin_hair_follicle_bulge.quiescent	0.01	Nonsignificant	0.08	1.49	Other	56	69
476	IPSC.neural_primed	0.01	Nonsignificant	1.00	0.49	Other	0	0
477	FIB.transitioning.secretory_procollagen	0.01	Nonsignificant	—	0.00	Other	0	0
478	MESO.baseline	0.01	Nonsignificant	0.87	0.59	Other	0	6
479	EC.arterial.inflammatory	0.01	Nonsignificant	0.95	0.86	Other	63	50
480	EPI.skin_interfollicular_spinous.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
481	ASPC.stem_like_progenitor	0.01	Nonsignificant	0.98	0.52	Other	300	842
482	EPI.tracheal_suprabasal.secretory_immune	0.01	Nonsignificant	—	0.38	Other	0	0
483	EC.venous.adipose_lipid	0.01	Nonsignificant	0.64	1.12	Other	254	476
484	FIB.barrier_secretory.homeostasis	0.01	Nonsignificant	—	0.00	Other	0	0
485	EPI.renal_principal_cell.canonical_vasopressin	0.01	Nonsignificant	0.08	1.60	Other	2	0
486	NEU.EXC_IT.guidance	0.01	Nonsignificant	1.00	0.42	Other	274	63
487	MONO.CD14.repair_M2_like	0.01	Nonsignificant	0.35	1.15	Other	550	1,495
488	FIB.adventitial.complement_angiocrine	0.01	Nonsignificant	0.99	0.60	Other	153	684
489	EPI.ileal_enterocyte_absorptive.brush_border	0.01	Nonsignificant	1.00	0.00	Other	580	1,717
490	EPI.skin_follicular_keratinizing.upper_infundibulum	0.01	Nonsignificant	—	0.06	Other	8	2
491	EC.arterial.arteriole_gas_exchange	0.01	Nonsignificant	0.16	1.20	Other	238	131
492	EPI.skin_hair_follicle_bulge.anagen_growth	9.94e-03	Nonsignificant	—	0.00	Other	0	0
493	EPI.skin_sweat_duct_keratinocyte.barrier	9.83e-03	Nonsignificant	—	0.67	Other	0	0
494	EPI.thymic_medullary.proliferative_APC	9.52e-03	Nonsignificant	—	0.72	Other	0	0
495	ASTRO.homeostatic	9.51e-03	Nonsignificant	0.99	0.91	Other	200	431
496	GRNLSA.angiocrine_mechanosensory	9.49e-03	Nonsignificant	—	0.35	Other	0	0
497	FIB.reticular.ECM_builder	9.43e-03	Nonsignificant	—	0.18	Other	0	0
498	EPI.ileal_goblet.inflammatory_mucin	9.30e-03	Nonsignificant	0.75	1.09	Other	6	9
499	EC.capillary.stress	9.29e-03	Nonsignificant	0.57	1.10	Other	44	36
500	EC.liver_sinusoidal.remodeling_lipotoxicity	9.26e-03	Nonsignificant	—	0.00	Other	90	58
501	DC.cDC2.monocyte_like	9.21e-03	Nonsignificant	1.00	0.46	Other	1,285	791
502	NEU.INH_LAMP5.exc_inh_balance	9.16e-03	Nonsignificant	—	0.20	Other	46	2
503	ADIPO.thermogenic	8.99e-03	Nonsignificant	—	0.62	Other	0	0
504	GRANU.neutrophil.antiviral_endotoxin	8.99e-03	Nonsignificant	—	0.00	Other	0	0
505	MG.expanding	8.94e-03	Nonsignificant	0.45	1.16	Other	2	1
506	EC.liver_sinusoidal.inflammatory	8.93e-03	Nonsignificant	—	0.00	Other	223	154
507	FIB.adventitial.PI16_matrix	8.83e-03	Nonsignificant	0.99	0.63	Other	70	90
508	SKM.type_1_slow.contractile	8.72e-03	Nonsignificant	0.04	1.21	Other	596	8
509	EPI.skin_follicular_keratinizing.transit_amplifying	8.71e-03	Nonsignificant	—	0.00	Other	21	49
510	ADIPO.inflammatory	8.57e-03	Nonsignificant	—	0.59	Other	0	0
511	MAC.resident_iron.heme_recycling	8.36e-03	Nonsignificant	—	0.00	Other	30	37
512	PERI.inflammatory	7.96e-03	Nonsignificant	0.57	1.08	Other	40	77
513	EPI.skin_hair_follicle_bulge.niche_crosstalk	7.85e-03	Nonsignificant	—	0.00	Other	29	88
514	EPI.thymic_cortical.secretory_remodeling	7.82e-03	Nonsignificant	—	1.23	Other	4	1
515	MAC.MDM.complement_resolving	7.82e-03	Nonsignificant	0.94	0.73	Other	440	860
516	EPI.alveolar_type_2.stress_response	7.75e-03	Nonsignificant	0.37	1.12	Other	675	1,562
517	EPI.skin_interfollicular_spinous.proliferative	7.67e-03	Nonsignificant	—	0.00	Other	0	0
518	ASTRO.hypoxia_angiogenic	7.62e-03	Nonsignificant	0.98	1.00	Other	5	18
519	EPI.thymic_medullary.canonical_alarmin	7.47e-03	Nonsignificant	0.71	1.01	Other	8	17
520	EC.capillary.activated	7.43e-03	Nonsignificant	0.57	1.29	Other	2	5
521	ADIPO.hypoxia_remodelling	7.23e-03	Nonsignificant	—	0.24	Other	29	105
522	EPI.renal_thick_ascending_limb.remodeling	7.11e-03	Nonsignificant	1.00	0.92	Other	152	92
523	MAC.resident_repair.chemokine_angiocrine	7.09e-03	Nonsignificant	0.85	0.87	Other	87	138
524	EPI.lung_multiciliated.mature_motile_cilia	7.00e-03	Nonsignificant	—	1.53	Other	0	0
525	EPI.esophageal_suprabasal.proliferative_S	6.99e-03	Nonsignificant	—	0.00	Other	26	41
526	EPI.renal_thick_ascending_limb.canonical_salt_transporter	6.69e-03	Nonsignificant	1.00	0.79	Other	322	317
527	IPSC.stromal_primed	6.66e-03	Nonsignificant	1.00	0.37	Other	0	0
528	EPI.renal_distal_tubule.ion_transport	6.63e-03	Nonsignificant	—	0.58	Other	0	0
529	EC.lymphatic.baseline	6.57e-03	Nonsignificant	0.65	1.39	Other	38	72
530	MESO.activated_stress	6.51e-03	Nonsignificant	—	0.00	Other	0	0
531	EC.arterial.metabolic	6.49e-03	Nonsignificant	0.95	0.71	Other	195	159
532	EC.arterial.ion_pump	6.48e-03	Nonsignificant	0.95	0.95	Other	3	2
533	EPI.thymic_medullary.stress_APC	6.42e-03	Nonsignificant	0.71	0.84	Other	2	4
534	NEU.INH_LAMP5.projecting	6.07e-03	Nonsignificant	—	0.71	Other	0	0
535	EC.lymphatic.scavenger	5.84e-03	Nonsignificant	0.65	1.15	Other	203	257
536	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	5.81e-03	Nonsignificant	—	0.37	Other	0	0
537	MAC.resident_repair.ECM_stromal_crosstalk	5.75e-03	Nonsignificant	0.85	0.78	Other	95	158
538	MG.baseline	5.64e-03	Nonsignificant	0.65	0.94	Other	16	5
539	FIB.neurolectin_mucosa.nerve_interface	5.64e-03	Nonsignificant	—	0.00	Other	4	0
540	FIB.reticular.stress_metallothionein	5.55e-03	Nonsignificant	—	0.00	Other	3	32
541	EC.arterial.arteriole_interface	5.48e-03	Nonsignificant	0.95	0.67	Other	31	12
542	EPI.skin_keratinocyte_basal.basement_anchoring	5.44e-03	Nonsignificant	—	0.00	Other	0	0
543	EPI.esophageal_basal.junctional_barrier	5.32e-03	Nonsignificant	—	0.00	Other	0	0
544	MAC.LAM.lipid_phagocytosis	5.30e-03	Nonsignificant	0.75	1.11	Other	369	328
545	FIB.interstitial.stress_secretory	5.28e-03	Nonsignificant	1.00	0.44	Other	92	56
546	ASTRO.immature_lipid	5.15e-03	Nonsignificant	0.99	0.80	Other	23	113
547	ASTRO.stress_mito	5.06e-03	Nonsignificant	0.98	0.99	Other	47	110
548	FIB.neurolectin_mucosa.axon_responsive	5.04e-03	Nonsignificant	0.84	0.76	Other	10	10
549	EPI.thymic_medullary.hormone_xeno_barrier	5.03e-03	Nonsignificant	—	0.00	Other	0	8
550	DC.cDC1.homeostatic_inhibitory	5.01e-03	Nonsignificant	—	0.00	Other	0	0
551	FIB.neurolectin_mucosa.inflammatory	4.78e-03	Nonsignificant	0.84	0.66	Other	52	110
552	EPI.tracheal_suprabasal.transitional_wound	4.76e-03	Nonsignificant	—	0.00	Other	16	1
553	DC.pDC.baseline	4.52e-03	Nonsignificant	0.26	1.26	Other	88	123
554	EPI.skin_appendage_keratinocyte.transit_amplifying	4.43e-03	Nonsignificant	—	0.00	Other	109	358
555	EPI.renal_proximal_tubule.onecarbon_peroxisome	4.39e-03	Nonsignificant	0.30	1.57	Other	58	89
556	EPI.renal_principal_cell.inflammatory	4.36e-03	Nonsignificant	0.87	1.14	Other	74	157
557	EPI.tracheal_basal.activated_stress	4.31e-03	Nonsignificant	0.33	1.37	Other	32	0
558	EC.capillary.postcap_venule	4.29e-03	Nonsignificant	0.57	1.08	Other	355	261
559	FIB.adventitial.mito_secretory	4.29e-03	Nonsignificant	0.99	0.37	Other	21	7
560	MAC.LAM.inflammatory_APC	4.21e-03	Nonsignificant	0.89	0.94	Other	872	165
561	FIB.interstitial.mesenchymal_APC	4.12e-03	Nonsignificant	1.00	0.32	Other	81	33
562	FIB.barrier_purinergic.stress_GF_binding	4.04e-03	Nonsignificant	—	0.00	Other	0	0
563	CHOND.remodeling	4.03e-03	Nonsignificant	—	0.32	Other	5	0
564	EC.capillary.angiocrine	4.01e-03	Nonsignificant	0.57	1.08	Other	250	630
565	EPI.renal_principal_cell.injury_repair	3.97e-03	Nonsignificant	0.87	0.81	Other	26	9
566	EPI.alveolar_type_2.baseline_surfactant	3.86e-03	Nonsignificant	0.56	1.01	Other	64	9
567	MAC.LAM.lipid_opsonization	3.75e-03	Nonsignificant	0.89	0.92	Other	45	14
568	PERI.angiocrine	3.72e-03	Nonsignificant	1.00	0.90	Other	93	102
569	EPI.esophageal_suprabasal.basal_transitional	3.70e-03	Nonsignificant	0.98	0.19	Other	44	67
570	MAC.resident_repair.stress_iron	3.68e-03	Nonsignificant	0.85	0.96	Other	48	97
571	EC.heart_remodeling.remodeling_secretory	3.58e-03	Nonsignificant	0.40	1.25	Other	605	1,341
572	EC.heart_remodeling.perivascular	3.53e-03	Nonsignificant	0.40	1.19	Other	124	408
573	EPI.ileal_goblet.baseline	3.48e-03	Nonsignificant	0.75	0.70	Other	16	2
574	EPI.salivary_myoepithelial.junctional_transport	3.45e-03	Nonsignificant	0.90	1.12	Other	66	121
575	GRANU.neutrophil.tissue_patrolling	3.44e-03	Nonsignificant	—	0.00	Other	0	0
576	EPI.tracheal_basal.homeostatic_progenitor	3.40e-03	Nonsignificant	0.94	0.49	Other	285	74
577	EC.heart_remodeling.activated_acute	3.40e-03	Nonsignificant	0.40	1.35	Other	102	186
578	MAC.resident_cardiac.antigen_presenting	3.37e-03	Nonsignificant	0.46	1.14	Other	52	27
579	EPI.renal_proximal_tubule.detox_antioxidant	3.35e-03	Nonsignificant	0.92	0.36	Other	394	77
580	EPI.ectocervical_granular.proliferative_basal	3.29e-03	Nonsignificant	—	0.00	Other	0	0
581	HPC.MPP_activated	3.26e-03	Nonsignificant	—	0.00	Other	0	0
582	MONO.CD14.APC_like	3.20e-03	Nonsignificant	0.35	1.10	Other	1,686	2,493
583	CM.baseline	3.17e-03	Nonsignificant	1.00	1.01	Other	393	0
584	EPI.renal_principal_cell.activated_acute	3.16e-03	Nonsignificant	0.87	1.00	Other	29	59
585	EPI.skin_interfollicular_spinous.transition_basal	3.11e-03	Nonsignificant	1.00	0.05	Other	100	127
586	EPI.renal_distal_tubule.repair	3.05e-03	Nonsignificant	—	0.13	Other	34	102
587	EC.arterial.mito_contact	2.97e-03	Nonsignificant	0.95	0.58	Other	14	5
588	EPI.skin_keratinocyte_proliferating.anchor_remodel	2.91e-03	Nonsignificant	—	0.55	Other	0	0
589	GRNLSA.secretory_remodeling	2.70e-03	Nonsignificant	0.94	0.83	Other	90	25
590	EC.capillary.baseline	2.68e-03	Nonsignificant	0.97	0.80	Other	246	560
591	MONO.CD14.inflammatory	2.66e-03	Nonsignificant	0.35	1.32	Other	92	134
592	MAC.kupffer.metabolic	2.65e-03	Nonsignificant	—	0.00	Other	25	36
593	EPI.ileal_goblet.stress_metallothionein	2.64e-03	Nonsignificant	—	0.00	Other	4	11
594	EPI.salivary_myoepithelial.baseline	2.63e-03	Nonsignificant	0.90	0.71	Other	42	141
595	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	2.59e-03	Nonsignificant	0.96	1.02	Other	7	16
596	EPI.salivary_myoepithelial.activated	2.54e-03	Nonsignificant	0.90	0.60	Other	85	281
597	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	2.54e-03	Nonsignificant	—	2.25e-03	Other	39	82
598	EPI.renal_thick_ascending_limb.cation_flux	2.50e-03	Nonsignificant	1.00	0.30	Other	57	95
599	EC.heart_remodeling.remodeling_stalk	2.46e-03	Nonsignificant	0.40	1.17	Other	33	111
600	SKM.type_1_slow.glycolytic	2.41e-03	Nonsignificant	1.00	0.88	Other	362	647
601	EPI.lung_club_secretory.canonical_surfactant	2.39e-03	Nonsignificant	—	0.26	Other	74	104
602	EPI.skin_sebaceous_duct_luminal.immune_interface	2.37e-03	Nonsignificant	—	0.00	Other	0	0
603	ASTRO.stress_acute	2.36e-03	Nonsignificant	0.99	0.77	Other	60	56
604	EC.lymphatic.activated	2.31e-03	Nonsignificant	0.94	0.47	Other	47	73
605	EC.venous.quiescent_homeostatic	2.28e-03	Nonsignificant	1.00	0.64	Other	456	360
606	EC.lymphatic.tip_migratory	2.24e-03	Nonsignificant	0.94	0.65	Other	23	37
607	EPI.renal_principal_cell.intercalated_like	2.18e-03	Nonsignificant	0.87	0.64	Other	63	66
608	MONO.CD16.baseline	2.15e-03	Nonsignificant	0.11	1.29	Other	50	1
609	EPI.esophageal_suprabasal.proliferative_G2M	2.11e-03	Nonsignificant	—	0.00	Other	0	0
610	EPI.lung_club_secretory.ciliogenesis_primed	2.02e-03	Nonsignificant	—	0.00	Other	0	0
611	DC.pDC.immature_metabolic	2.01e-03	Nonsignificant	0.57	1.09	Other	78	124
612	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.94e-03	Nonsignificant	—	0.39	Other	135	290
613	EPI.esophageal_suprabasal.proliferative_exit	1.93e-03	Nonsignificant	—	0.00	Other	0	0
614	MAC.resident_cardiac.inflammatory_reparative	1.91e-03	Nonsignificant	0.46	1.19	Other	31	96
615	MAC.proliferating.DNA_replication	1.85e-03	Nonsignificant	0.06	1.50	Other	3	6
616	MAC.resident_cardiac.phagocytic_homeostasis	1.85e-03	Nonsignificant	0.86	0.84	Other	564	1,221
617	MAC.microglia_like.patrolling_adhesive	1.80e-03	Nonsignificant	—	0.00	Other	0	0
618	EPI.lung_multiciliated.baseline	1.74e-03	Nonsignificant	—	0.51	Other	0	7
619	EC.capillary.migratory	1.73e-03	Nonsignificant	0.86	0.91	Other	181	509
620	MONO.CD16.platelet_bound	1.62e-03	Nonsignificant	0.34	1.24	Other	372	508
621	EC.capillary.angiogenic_tip	1.60e-03	Nonsignificant	0.86	0.84	Other	186	218
622	MAC.LAM.antimicrobial	1.57e-03	Nonsignificant	0.89	0.79	Other	389	93
623	PERI.cardiac_skeletal	1.45e-03	Nonsignificant	1.00	0.51	Other	313	630
624	NEU.INH_PVALB.nuclear_reg	1.41e-03	Nonsignificant	0.93	0.59	Other	25	12
625	NEU.INH_PVALB.serotonergic	1.35e-03	Nonsignificant	—	0.00	Other	0	0
626	MAC.kupffer.inflammatory	1.35e-03	Nonsignificant	—	0.00	Other	7	4
627	MONO.CD16.patrolling	1.29e-03	Nonsignificant	0.18	1.14	Other	797	216
628	EPI.cervical_suprabasal.secretory_vesicle	1.26e-03	Nonsignificant	—	0.00	Other	0	0
629	MONO.CD16.hepatic_mac_like	1.25e-03	Nonsignificant	0.05	1.34	Other	803	117
630	EPI.cervical_suprabasal.inflammatory_repair	1.23e-03	Nonsignificant	—	0.00	Other	0	0
631	EC.arterial.angiogenic_tip	1.23e-03	Nonsignificant	—	0.00	Other	30	37
632	MAC.LAM.perivascular_angiocrine	1.22e-03	Nonsignificant	—	0.09	Other	53	138
633	MONO.CD14.remodeling	1.21e-03	Nonsignificant	0.62	1.02	Other	2,373	295
634	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.10e-03	Nonsignificant	0.96	0.41	Other	33	34
635	EPI.ectocervical_granular.immune_interact	1.06e-03	Nonsignificant	—	0.00	Other	0	0
636	MAC.kupffer.fibrogenic	1.04e-03	Nonsignificant	—	0.00	Other	0	0
637	GRNLSA.proliferative_migratory	1.03e-03	Nonsignificant	1.00	0.20	Other	248	292
638	GRNLSA.p53_damage	9.80e-04	Nonsignificant	—	0.00	Other	13	10
639	MONO.CD14.baseline	8.81e-04	Nonsignificant	1.00	0.88	Other	2,268	76
640	ASPC.signal_integrator	7.95e-04	Nonsignificant	—	0.00	Other	0	0
641	NEU.EXC_NTNG1.nuclear_reg	7.30e-04	Nonsignificant	—	0.67	Other	0	0
642	EC.heart_remodeling.angiocrine	7.29e-04	Nonsignificant	1.00	0.40	Other	182	525
643	ASTRO.A1_reactive	6.81e-04	Nonsignificant	0.99	0.63	Other	433	394
644	EPI.skin_sweat_duct_keratinocyte.signal_gate	6.58e-04	Nonsignificant	—	0.00	Other	43	26
645	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	6.31e-04	Nonsignificant	—	0.00	Other	0	0
646	EPI.lung_multiciliated.stress	5.26e-04	Nonsignificant	—	0.00	Other	67	165
647	SKM.type_1_slow.oxidative	5.05e-04	Nonsignificant	1.00	0.42	Other	802	251
648	EPI.skin_sweat_duct_keratinocyte.proliferative_S	4.93e-04	Nonsignificant	—	0.00	Other	0	0
649	HPC.MEP	4.89e-04	Nonsignificant	1.00	0.31	Other	599	1,195
650	MAC.proliferating.stress	4.75e-04	Nonsignificant	—	0.00	Other	87	136
651	DC.pDC.poised_migratory	4.58e-04	Nonsignificant	0.57	1.02	Other	54	95
652	CHOND.articular_collagen	4.03e-04	Nonsignificant	1.00	0.13	Other	551	266
653	EC.heart_remodeling.translation_boost	3.75e-04	Nonsignificant	—	0.00	Other	0	0
654	MONO.CD16.inflammatory	3.36e-04	Nonsignificant	0.99	0.66	Other	1,640	168
655	EPI.skin_keratinocyte_proliferating.detox_repair	2.80e-04	Nonsignificant	—	0.00	Other	0	0
656	EC.venous.remodeling_stalk	2.25e-04	Nonsignificant	1.00	0.09	Other	559	566
657	EC.heart_remodeling.capillary_metabolic	2.21e-04	Nonsignificant	1.00	0.05	Other	54	414
658	EPI.salivary_intercalated_defense.basal_EMT	2.16e-04	Nonsignificant	—	0.00	Other	0	0
659	ADIPO.immature	1.83e-04	Nonsignificant	—	0.00	Other	24	40
660	SKM.type_2_fast.oxidative_IIa	1.59e-04	Nonsignificant	0.03	1.06	Other	946	56
661	EPI.renal_distal_tubule.immune_modulatory	1.48e-04	Nonsignificant	—	0.00	Other	0	0
662	EPI.endocervical_secretory.squamous_barrier	1.42e-04	Nonsignificant	—	0.00	Other	0	0
663	CM.osmoprotection	1.38e-04	Nonsignificant	1.00	1.00	Other	34	57
664	MAC.alveolar.capillary_interacting	1.31e-04	Nonsignificant	0.65	1.18	Other	113	181
665	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	1.18e-04	Nonsignificant	—	0.00	Other	0	0
666	EPI.lung_club_secretory.ciliogenesis_axoneme	9.33e-05	Nonsignificant	—	0.00	Other	0	0
667	MAC.alveolar.lipid_autophagy	8.92e-05	Nonsignificant	—	0.82	Other	35	44
668	MAC.alveolar.stress_metabolic	7.89e-05	Nonsignificant	0.65	1.14	Other	116	148
669	MONO.CD14.cord_tolerance	7.17e-05	Nonsignificant	1.00	0.67	Other	864	753
670	EPI.renal_distal_tubule.stress	3.29e-05	Nonsignificant	—	0.00	Other	0	0
671	CM.mechano_activated	2.04e-05	Nonsignificant	1.00	1.00	Other	205	134
672	NEU.INH_LAMP5.glial_interface	1.17e-05	Nonsignificant	—	0.00	Other	0	0
673	MAC.alveolar.inflammatory	1.05e-05	Nonsignificant	0.96	0.97	Other	208	312
674	NEU.INH_PVALB.fastspike	8.34e-06	Nonsignificant	—	0.00	Other	24	22
675	CM.mito_proteostasis	8.29e-06	Nonsignificant	1.00	0.98	Other	329	29
676	NEU.INH_LAMP5.rosehip	7.55e-06	Nonsignificant	—	0.00	Other	0	0
677	CM.sarcomere_actin_interface	5.93e-06	Nonsignificant	1.00	0.94	Other	450	78
678	CM.oxidative_phospho	3.48e-06	Nonsignificant	1.00	0.95	Other	266	792
679	SKM.type_2_fast.glycolytic_IIx_IIb	2.92e-06	Nonsignificant	0.78	0.93	Other	565	1,482
680	CM.translation_boost_RPL	1.66e-06	Nonsignificant	1.00	0.93	Other	129	1
681	NEU.EXC_NTNG1.synaptic	1.45e-06	Nonsignificant	—	0.00	Other	0	0
682	NEU.INH_PVALB.neuromodulatory	1.45e-06	Nonsignificant	—	0.00	Other	0	0
683	MAC.alveolar.biosynthetic_sterol_heme	4.54e-07	Nonsignificant	0.97	0.51	Other	347	40
684	CM.translation_boost_RPS	1.88e-08	Nonsignificant	1.00	0.93	Other	69	16
685	MAC.alveolar.scavenging_endocytic	6.57e-09	Nonsignificant	—	0.00	Other	140	283
686	CM.anti_inflammatory	9.85e-10	Nonsignificant	1.00	0.80	Other	424	1,503
687	EPI.thymic_cortical.Notch_interface	3.53e-11	Nonsignificant	—	0.18	Other	82	137
688	EPI.thymic_cortical.baseline	9.05e-12	Nonsignificant	1.00	0.00	Other	185	386

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

77 unique genes. Showing 1–77. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
TRBJ2-5	01-High	0.71	14.39	G1	C1	—	—	—	6	10
TRBJ2-6	01-High	0.71	14.39	G1	C1	—	—	—	6	10
TRBJ2-7	01-High	0.71	14.39	G1	C1	—	—	—	6	10
TRBJ2-1	01-High	0.71	14.37	G1	C1	—	—	—	6	10
TRBJ2-2	01-High	0.71	14.37	G1	C1	—	—	—	6	10
TRBJ2-2P	01-High	0.71	14.37	G1	C1	—	—	—	6	10
TRBJ2-3	01-High	0.71	14.37	G1	C1	—	—	—	6	10
TRBJ2-4	01-High	0.71	14.37	G1	C1	—	—	—	6	10
TRBV30	01-High	0.64	12.55	G1	C1	—	—	—	5	7
ENSG00000290099	01-High	0.63	9.09	G1	C1	—	—	—	2	3
ABCG8	01-High	0.60	5.77	G1	C1	—	HEP.periportal_metabolic (Tier: specific)	6 cells — complete matches	70	517
ABCG5	01-High	0.55	6.12	G1	C1	—	HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.inflammatory_activated (Tier: specific) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant)	8 cells — complete matches	70	518
ENSG00000305165	01-High	0.54	7.00	G1	C1	—	—	—	70	518
DYNC2LI1	01-High	0.45	6.30	G1	C1	—	—	7 cells — complete matches	65	511
PRSS2	02-Medium	0.75	13.17	G1	C2	EPI.pancreatic_acinar (L1S), EPI.pancreatic_acinar.baseline (L2), EPI.pancreatic_ductal_progenitor.ADM_like (L2)	EPI.pancreatic_acinar (Tier: specific) EPI.pancreatic_acinar.adhesion_remodeling (Tier: specific) EPI.pancreatic_acinar.inflammatory_regenerative (Tier: relevant)	33 cells — complete matches	2	1
TRBD1	02-Medium	0.72	13.40	G1	C2	—	—	—	2	3
TRBJ1-1	02-Medium	0.71	12.62	G1	C2	—	—	—	3	3
TRBC1	02-Medium	0.69	12.47	G1	C2	T_cell (L1)	—	—	6	9
TRBC2	02-Medium	0.68	13.90	G1	C2	—	—	—	5	6
ENSG00000310430	02-Medium	0.68	14.17	G1	C2	—	—	—	3	3
TRBJ1-3	02-Medium	0.65	9.87	G1	C2	—	—	—	3	3
TRBJ1-4	02-Medium	0.65	9.87	G1	C2	—	—	—	3	3
TRBJ1-5	02-Medium	0.65	9.87	G1	C2	—	—	—	3	3
TRBJ1-6	02-Medium	0.65	9.87	G1	C2	—	—	—	3	3
TRBV28	02-Medium	0.64	11.33	G1	C2	—	—	—	3	3
ENSG00000299979	02-Medium	0.64	13.61	G1	C2	—	—	—	3	4
SPINK1	02-Medium	0.64	16.55	G1	C2	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.pancreatic_acinar.baseline (L2), EPI.pancreatic_ductal_progenitor.ADM_like (L2)	EPI.pancreatic_acinar (Tier: specific) EPI.colonocyte.secretory_boost (Tier: specific) EPI.pancreatic_acinar.adhesion_remodeling (Tier: specific) EPI.pancreatic_ductal_bicarbonate.barrier_mucin (Tier: specific) EPI.pancreatic_ductal_mucinous (Tier: relevant) EPI.pancreatic_acinar.inflammatory_regenerative (Tier: relevant) EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (Tier: relevant) EPI.pancreatic_ductal_mucinous.remodeling_channel_rich (Tier: relevant)	66 cells — complete matches	2	2
TRBV20-1	02-Medium	0.63	11.12	G1	C2	—	—	—	7	10
PRSS3P1	02-Medium	0.62	7.27	G1	C2	—	—	—	2	1
EPHB6	02-Medium	0.61	11.99	G1	C2	NEU.INH_LAMP5.projecting (L2), NEU.INH_VIP.matrix (L2)	T.MAIT (Tier: specific) THYMO.SP_CD8_naive (Tier: specific) T.CD4_Treg (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion (Tier: relevant) T.CD4_naive.mature_mitoprot (Tier: relevant) T.CD4_naive.survival_neddylation (Tier: relevant) T.CD4_Tcm.imprinted_splicing (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.MAIT.MAPK_brake (Tier: relevant) T.MAIT.vesicle (Tier: relevant) THYMO.CD8aa_IELp (Tier: relevant)	67 cells — complete matches	8	11
SCGB3A2	02-Medium	0.60	17.11	G1	C2	EPI.lung_club_secretory.canonical_surfactant (L2)	—	15 cells — complete matches	2	2
TRBV19	02-Medium	0.59	11.88	G1	C2	—	—	—	1	2
ENSG00000292271	02-Medium	0.59	9.13	G1	C2	—	—	—	3	3
TRBV29-1	02-Medium	0.58	8.58	G1	C2	—	—	—	3	3
ENSG00000287630	02-Medium	0.56	13.36	G1	C2	—	—	—	1	1
ENSG00000308063	02-Medium	0.56	9.40	G1	C2	—	—	—	8	11
TRPV6	02-Medium	0.56	8.21	G1	C2	EPI.pancreatic_ductal_bicarbonate.baseline (L2)	EPI.salivary_serous_acinar (Tier: specific) EPI.pancreatic_ductal_bicarbonate.barrier_mucin (Tier: specific) EPI.extrahepatic_cholangiocyte.mucin_secretory (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (Tier: relevant) EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.junctional_remodel (Tier: relevant) EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump (Tier: relevant)	49 cells — complete matches	3	4
ENSG00000289938	02-Medium	0.55	11.64	G1	C2	—	—	—	1	1
PRSS1	02-Medium	0.55	7.42	G1	C2	EPI.pancreatic_acinar (L1S), EPI.pancreatic_acinar.baseline (L2)	EPI.pancreatic_acinar (Tier: specific) EPI.pancreatic_acinar.adhesion_remodeling (Tier: specific) EPI.pancreatic_acinar.inflammatory_regenerative (Tier: relevant)	17 cells — complete matches	9	9
JAKMIP2	02-Medium	0.55	9.92	G1	C2	—	T.CD4_Tem (Tier: specific) T.CD8_Tem (Tier: specific) T.CD8_transitional (Tier: specific) NK.adaptive_biosynthetic_primed (Tier: specific) NK.adaptive_classII_inhibitory (Tier: specific) T.CD8_Tcm.effector_bias (Tier: specific) T.CD8_Trm (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_Tcm.retro_ZNF117 (Tier: relevant) T.CD4_Tcm.stress (Tier: relevant) T.CD4_Tcm.Tfh_like (Tier: relevant) T.CD4_Tem.cytotoxic_effector (Tier: relevant) T.CD4_Th2.precursor (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD4_transitional.tissue_enagement (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant) T.CD8_Tem.signaling_turnover (Tier: relevant) T.CD8_Trm.dendritic_recruiter (Tier: relevant) T.CD8_Trm.inflammatory (Tier: relevant) T.CD8_Trm.muscosal_Tc17 (Tier: relevant)	67 cells — complete matches	1	1
ENSG00000308045	02-Medium	0.55	10.71	G1	C2	—	—	—	3	3
ENSG00000305298	02-Medium	0.54	6.74	G1	C2	—	—	—	3	4
ENSG00000286831	02-Medium	0.54	6.45	G1	C2	—	—	—	2	1
ENSG00000288882	02-Medium	0.54	6.45	G1	C2	—	—	—	4	9
TRBV27	02-Medium	0.54	6.45	G1	C2	—	—	—	4	9
TRBV23-1	02-Medium	0.53	4.30	G1	C2	—	—	—	1	2
TRPV5	02-Medium	0.53	9.14	G1	C2	—	—	6 cells — complete matches	3	7
CTRB1	02-Medium	0.53	3.51	G1	C2	EPI.pancreatic_acinar.baseline (L2)	EPI.pancreatic_acinar (Tier: specific) EPI.pancreatic_acinar.adhesion_remodeling (Tier: specific) EPI.pancreatic_acinar.inflammatory_regenerative (Tier: relevant)	22 cells — complete matches	42	59
ARHGEF35	02-Medium	0.52	7.92	G1	C2	—	NK.adaptive_immature_precursor (Tier: specific) T.CD4_transitional (Tier: relevant) T.CD4_cytotoxic.activated (Tier: relevant) T.CD4_transitional.primed_helper_effector (Tier: relevant) T.CD8_Tcm.helper_like (Tier: relevant)	27 cells — complete matches	1	0
TRBV24-1	02-Medium	0.49	5.38	G1	C2	—	—	—	2	2
TRBV25-1	02-Medium	0.49	4.71	G1	C2	—	—	—	3	7
TRBV18	02-Medium	0.49	4.56	G1	C2	—	—	—	2	2
ARHGEF35-AS1	02-Medium	0.48	4.84	G1	C2	—	—	—	1	0
ENSG00000240338	02-Medium	0.47	3.84	G1	C2	—	—	—	40	58
ENSG00000290455	02-Medium	0.47	3.84	G1	C2	—	—	—	40	58
ENSG00000291149	02-Medium	0.46	2.19	G1	C2	—	—	—	5	7
TRBV10-3	02-Medium	0.46	5.15	G1	C2	—	—	—	0	0
KEL	02-Medium	0.45	5.08	G1	C2	—	—	12 cells — complete matches	6	9
TRBV15	02-Medium	0.45	3.63	G1	C2	—	—	—	1	0
TRBV16	02-Medium	0.44	6.71	G1	C2	—	—	—	1	0
TRBV12-5	02-Medium	0.43	2.85	G1	C2	—	—	—	1	0
BCAR1	02-Medium	0.42	2.32	G1	C2	—	T.CD4_Tcm.retro_ZNF117 (Tier: relevant)	14 cells — complete matches	53	82
TRBV7-3	02-Medium	0.40	4.46	G1	C2	—	—	—	0	0
CTRB2	02-Medium	0.37	2.60	G1	C2	EPI.pancreatic_acinar (L1S), EPI.pancreatic_acinar.baseline (L2), EPI.pancreatic_ductal_progenitor.ADM_like (L2)	EPI.pancreatic_acinar (Tier: specific) EPI.pancreatic_acinar.adhesion_remodeling (Tier: specific) EPI.pancreatic_acinar.inflammatory_regenerative (Tier: relevant)	16 cells — complete matches	32	49
ENSG00000261783	02-Medium	0.36	1.87	G1	C2	—	—	—	23	23
ENSG00000280152	02-Medium	0.36	1.94	G1	C2	—	—	—	24	23
C5orf46	02-Medium	0.36	9.28	G2	C2	EPI.skin_sweat_duct_keratinocyte.barrier (L2)	EPI.salivary_serous_acinar (Tier: specific)	29 cells — complete matches	2	2
CFDP1	02-Medium	0.36	2.52	G1	C2	—	—	T.CD8_Tem.motility_primed (L2)	28	31
TRBJ1-2	02-Medium	0.28	10.89	G2	C1	—	—	—	1	2
PLEKHH2	02-Medium	0.27	4.14	G2	C1	ASTRO.synaptic_interaction (L2), OPC.homeostatic (L2)	T.CD8_Trm.dendritic_recruiter (Tier: relevant)	46 cells — complete matches	19	44
ENSG00000296114	02-Medium	0.24	1.68	G1	C2	—	—	—	19	20
ZFP1	02-Medium	0.22	2.42	G1	C2	—	T.CD4_Treg (Tier: relevant) T.CD8_Tem.early_helper_like (Tier: relevant)	19 cells — complete matches	10	9
ENSG00000261717	02-Medium	0.21	1.44	G1	C2	—	—	—	29	53
TMEM170A	02-Medium	0.21	1.44	G1	C2	—	—	B.age_associated.naive_transitional (L2), T.CD4_Tem.transitional_CM (L2)	29	53
ENSG00000274220	02-Medium	0.20	1.18	G1	C2	—	—	—	10	10
ENSG00000296154	02-Medium	0.20	1.18	G1	C2	—	—	—	10	10
HYDIN	02-Medium	0.15	0.06	G2	C2	EPI.lung_multiciliated.mature_motile_cilia (L2), NEU.EXC_IT.structural (L2)	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion (Tier: relevant)	15 cells — complete matches	12	14

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.