Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000023 · All tissues

Acute laryngitis and tracheitis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Upper respiratory inflammation

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	cardiomyocyte	72.85	Significant	3.30e-49	1.22	Specific	533	2,045
2	oligodendrocyte	9.81	Significant	1.33e-09	1.11	Specific	385	1,507
3	mesothelial_cell	9.72	Significant	1.00	1.01	Relevant	6	36
4	hepatocyte	4.70	Nominal	1.00	1.02	Other	1,515	3,822
5	fibroblast	3.87	Nominal	0.90	1.02	Other	184	826
6	endothelial_cell	2.67	Nonsignificant	1.00	0.99	Other	373	974
7	skeletal_muscle_cell	1.69	Nonsignificant	1.00	0.96	Other	944	2,600
8	smooth_muscle_cell	0.95	Nonsignificant	1.00	0.83	Other	27	139
9	macrophage	0.87	Nonsignificant	1.00	0.85	Other	813	1,732
10	epithelial_cell	0.68	Nonsignificant	1.00	0.86	Other	24	47
11	dendritic_cell	0.68	Nonsignificant	1.00	0.84	Other	496	724
12	plasma_cell	0.54	Nonsignificant	1.00	0.81	Other	17	24
13	pericyte	0.48	Nonsignificant	1.00	0.81	Other	128	517
14	innate_lymphoid_cell_2	0.34	Nonsignificant	1.00	1.00	Other	3	8
15	granulocyte	0.32	Nonsignificant	1.00	0.81	Other	5	6
16	thymocyte	0.26	Nonsignificant	1.00	0.77	Other	168	512
17	adipose_stem_and_progenitor_cell	0.20	Nonsignificant	1.00	0.73	Other	327	954
18	haematopoietic_progenitor_cell	0.17	Nonsignificant	1.00	0.72	Other	262	502
19	monocyte	0.11	Nonsignificant	1.00	0.78	Other	2,176	3,871
20	muscle_stem_cell	0.09	Nonsignificant	1.00	0.64	Other	7	27
21	neuron	0.08	Nonsignificant	1.00	0.65	Other	330	1,328
22	microglia	0.07	Nonsignificant	1.00	0.64	Other	61	129
23	adipocyte	0.05	Nonsignificant	1.00	0.78	Other	33	111
24	natural_killer_cell	0.04	Nonsignificant	1.00	0.75	Other	1,204	2,052
25	induced_pluripotent_stem_cell	0.03	Nonsignificant	1.00	0.68	Other	0	0
26	platelet	0.03	Nonsignificant	—	0.21	Other	85	104
27	B_cell	0.03	Nonsignificant	1.00	0.55	Other	356	694
28	astrocyte	0.02	Nonsignificant	1.00	0.67	Other	256	1,203
29	T_cell	0.02	Nonsignificant	1.00	0.43	Other	470	959
30	oligodendrocyte_precursor_cell	0.02	Nonsignificant	1.00	0.49	Other	461	1,454
31	melanocyte	0.01	Nonsignificant	1.00	0.50	Other	97	309
32	granulosa_cell	8.91e-03	Nonsignificant	1.00	0.46	Other	293	670
33	chondrocyte	8.26e-03	Nonsignificant	1.00	0.50	Other	548	1,069
34	schwann_cell	1.54e-03	Nonsignificant	1.00	0.32	Other	10	57

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	CM.cardiomyocyte	72.85	Significant	—	—	Specific	524	2,032
2	EPI.pancreatic_islet	13.86	Significant	0.30	1.26	Relevant	52	132
3	EC.liver_sinusoidal	13.11	Significant	0.06	1.14	Relevant	1,083	1,925
4	EC.heart_remodeling	11.41	Significant	3.71e-10	1.28	Specific	569	1,594
5	OLG.oligodendrocyte	9.81	Significant	—	—	Specific	384	1,397
6	MESO.mesothelial_cell	9.72	Significant	—	—	Relevant	2	18
7	FIB.adventitial	7.88	Significant	9.26e-49	1.73	Specific	268	1,447
8	HEP.acute_phase	5.44	Nominal	1.52e-03	1.54	Other	1,441	3,641
9	HEP.canalicular_transport	5.19	Nominal	0.02	1.35	Other	1,290	3,434
10	EPI.endocervical_secretory	3.84	Nominal	—	1.31	Other	0	0
11	HEP.periportal_metabolic	3.73	Nominal	1.00	0.44	Other	1,750	4,427
12	FIB.hepatic_stellate_cell	3.71	Nominal	—	0.27	Other	64	252
13	EPI.skin_sebaceous_duct_luminal	3.64	Nominal	0.67	1.19	Other	100	249
14	EPI.pancreatic_acinar	2.97	Nonsignificant	7.12e-09	1.30	Other	429	1,475
15	EC.arterial	2.86	Nonsignificant	0.10	1.05	Other	356	885
16	EPI.renal_distal_tubule	2.53	Nonsignificant	1.00	1.14	Other	133	361
17	MAC.alveolar	2.10	Nonsignificant	4.56e-06	1.61	Other	1,432	3,122
18	EPI.ileal_enterocyte_crypt	2.07	Nonsignificant	1.00	1.09	Other	67	113
19	SKM.type_2_fast	1.71	Nonsignificant	0.36	1.32	Other	972	2,639
20	SKM.type_1_slow	1.66	Nonsignificant	0.76	0.74	Other	923	2,478
21	MAC.kupffer	1.64	Nonsignificant	0.32	1.18	Other	189	530
22	MAC.resident_cardiac	1.45	Nonsignificant	2.77e-04	1.39	Other	485	1,074
23	EPI.pancreatic_ductal_mucinous	1.39	Nonsignificant	1.00	1.06	Other	219	430
24	EPI.skin_keratinocyte_progenitor	1.26	Nonsignificant	—	0.99	Other	0	3
25	EPI.renal_intercalated_cell_type_A	1.15	Nonsignificant	1.00	0.92	Other	67	142
26	EPI.colonic_tuft	1.11	Nonsignificant	—	0.95	Other	7	24
27	SMC.smooth_muscle_cell	0.95	Nonsignificant	—	—	Other	20	101
28	DC.mig	0.93	Nonsignificant	—	0.49	Other	89	156
29	EPI.skin_keratinocyte_basal	0.91	Nonsignificant	—	0.85	Other	13	26
30	DC.cDC2	0.88	Nonsignificant	1.07e-05	1.45	Other	1,189	1,793
31	EPI.salivary_duct_ion_transport	0.85	Nonsignificant	1.00	1.04	Other	5	11
32	EPI.ectocervical_granular	0.81	Nonsignificant	—	0.88	Other	11	23
33	GRANU.neutrophil	0.80	Nonsignificant	9.43e-04	1.50	Other	1,235	2,649
34	EPI.alveolar_type_2	0.78	Nonsignificant	1.00	0.99	Other	813	1,853
35	EPI.salivary_duct_excretory	0.70	Nonsignificant	1.00	0.95	Other	85	180
36	MAC.LAM	0.66	Nonsignificant	1.00	0.79	Other	914	2,064
37	MAC.MDM	0.65	Nonsignificant	1.00	0.78	Other	623	986
38	EPI.skin_keratinocyte_proliferating	0.63	Nonsignificant	1.00	1.03	Other	47	76
39	EPI.salivary_intercalated_defense	0.61	Nonsignificant	1.00	0.90	Other	81	161
40	EPI.skin_hair_follicle_companion	0.60	Nonsignificant	—	0.62	Other	8	12
41	PC.IgA_muocsal	0.58	Nonsignificant	2.83e-04	1.69	Other	18	31
42	EPI.colonic_enteroendocrine	0.50	Nonsignificant	—	0.44	Other	1	1
43	PERI.pericyte	0.48	Nonsignificant	—	—	Other	117	0
44	MAC.microglia_like	0.48	Nonsignificant	1.00	0.86	Other	124	179
45	MAC.proliferating	0.47	Nonsignificant	1.00	0.65	Other	87	253
46	EPI.ileal_bile_transport	0.47	Nonsignificant	1.00	0.95	Other	61	93
47	EPI.bile_duct_cholangiocyte	0.42	Nonsignificant	1.00	0.84	Other	37	60
48	EPI.renal_immature_ureteric_bud	0.41	Nonsignificant	1.00	0.82	Other	217	569
49	B.germinal_center	0.40	Nonsignificant	0.01	1.46	Other	233	655
50	EPI.gastric_foveolar	0.39	Nonsignificant	—	0.62	Other	0	0
51	EPI.renal_principal_cell	0.38	Nonsignificant	1.00	0.83	Other	207	403
52	EPI.esophageal_suprabasal	0.35	Nonsignificant	1.00	0.82	Other	158	404
53	EC.capillary	0.34	Nonsignificant	1.00	0.70	Other	514	1,635
54	ILC2.innate_lymphoid_cell_2	0.34	Nonsignificant	—	—	Other	2	0
55	MAC.resident_repair	0.30	Nonsignificant	9.36e-04	1.35	Other	796	1,426
56	FIB.suburothelial	0.30	Nonsignificant	1.00	0.66	Other	122	432
57	PC.IgG_systemic	0.28	Nonsignificant	0.21	1.16	Other	41	60
58	EPI.extrahepatic_cholangiocyte	0.28	Nonsignificant	—	0.12	Other	37	71
59	EC.venous	0.26	Nonsignificant	1.00	0.61	Other	516	1,387
60	THYMO.thymocyte	0.26	Nonsignificant	—	—	Other	163	495
61	FIB.interstitial	0.24	Nonsignificant	1.00	0.34	Other	288	940
62	MAC.resident_iron	0.22	Nonsignificant	1.00	0.31	Other	16	21
63	ASPC.adipose_stem_and_progenitor_cell	0.20	Nonsignificant	—	—	Other	324	930
64	EPI.renal_thick_ascending_limb	0.19	Nonsignificant	1.00	0.78	Other	453	1,153
65	HEP.pericentral_lipoprotein	0.18	Nonsignificant	—	0.00	Other	0	0
66	HPC.haematopoietic_progenitor_cell	0.17	Nonsignificant	—	—	Other	211	370
67	NEU.EXC_SYT2	0.16	Nonsignificant	—	1.08	Other	40	77
68	FIB.perivascular_interface	0.14	Nonsignificant	1.00	0.54	Other	0	0
69	MONO.CD14	0.13	Nonsignificant	6.12e-05	1.09	Other	2,294	4,139
70	NEU.EXC_CT	0.13	Nonsignificant	0.98	1.05	Other	362	384
71	EPI.colonocyte	0.12	Nonsignificant	1.00	0.78	Other	294	815
72	NEU.EXC_IT	0.11	Nonsignificant	0.02	1.25	Other	411	192
73	EPI.hepatic_ductular_cholangiocyte	0.10	Nonsignificant	1.00	0.68	Other	83	243
74	EPI.ileal_enterocyte_absorptive	0.09	Nonsignificant	1.00	0.78	Other	118	338
75	FIB.skin_neurosecretory	0.09	Nonsignificant	—	0.00	Other	0	0
76	FIB.barrier_purinergic	0.09	Nonsignificant	—	0.00	Other	1	3
77	MUSC.muscle_stem_cell	0.09	Nonsignificant	—	—	Other	4	18
78	EPI.intrahepatic_cholangiocyte_defense	0.09	Nonsignificant	—	0.00	Other	8	13
79	EPI.lung_multiciliated	0.08	Nonsignificant	1.00	0.86	Other	16	49
80	EPI.pancreatic_ductal_perivascular	0.08	Nonsignificant	1.00	0.70	Other	4	30
81	MG.microglia	0.07	Nonsignificant	—	—	Other	49	0
82	EPI.pancreatic_ductal_bicarbonate	0.06	Nonsignificant	1.00	0.65	Other	131	548
83	DC.cDC1	0.06	Nonsignificant	1.00	0.41	Other	55	112
84	FIB.reticular	0.05	Nonsignificant	1.00	0.38	Other	19	87
85	NEU.EXC_NTNG1	0.05	Nonsignificant	—	0.40	Other	0	0
86	ADIPO.adipocyte	0.05	Nonsignificant	—	—	Other	20	62
87	GRANU.MAST	0.05	Nonsignificant	1.00	0.00	Other	5	6
88	NK.natural_killer_cell	0.04	Nonsignificant	—	—	Other	1,204	2,045
89	EPI.tracheal_submucosal_gland	0.04	Nonsignificant	—	0.04	Other	0	0
90	T.CD8_transitional	0.04	Nonsignificant	3.28e-04	1.20	Other	497	932
91	EPI.alveolar_type_1	0.04	Nonsignificant	1.00	0.68	Other	26	101
92	EPI.thymic_medullary	0.04	Nonsignificant	1.00	0.56	Other	26	133
93	IPSC.induced_pluripotent_stem_cell	0.03	Nonsignificant	—	—	Other	0	0
94	T.CD8_naive	0.03	Nonsignificant	0.83	1.00	Other	317	708
95	PLAT.platelet	0.03	Nonsignificant	—	0.00	Other	38	53
96	T.CD4_Tfh	0.03	Nonsignificant	0.56	1.09	Other	47	45
97	B.naive	0.03	Nonsignificant	0.02	1.13	Other	307	595
98	EPI.renal_proximal_tubule	0.03	Nonsignificant	1.00	0.61	Other	525	806
99	NEU.INH_PVALB	0.03	Nonsignificant	1.00	0.62	Other	193	183
100	EPI.skin_hair_follicle_bulge	0.02	Nonsignificant	1.00	0.54	Other	51	178
101	T.CD4_Trm	0.02	Nonsignificant	0.56	1.06	Other	176	363
102	ASTRO.astrocyte	0.02	Nonsignificant	—	—	Other	228	1,111
103	T.CD4_naive	0.02	Nonsignificant	0.83	0.99	Other	399	866
104	EPI.skin_follicular_keratinizing	0.02	Nonsignificant	1.00	0.47	Other	30	81
105	T.CD8_Trm	0.02	Nonsignificant	0.40	1.11	Other	211	346
106	MONO.CD16	0.02	Nonsignificant	1.00	0.93	Other	1,304	1,835
107	EPI.renal_intercalated_cell_type_B	0.02	Nonsignificant	—	0.00	Other	6	7
108	OPC.oligodendrocyte_precursor_cell	0.02	Nonsignificant	—	—	Other	413	1,269
109	T.CD4_Th2	0.02	Nonsignificant	—	0.98	Other	1	2
110	B.age_associated	0.02	Nonsignificant	1.00	0.78	Other	207	350
111	EPI.salivary_myoepithelial	0.02	Nonsignificant	1.00	0.95	Other	191	714
112	EPI.skin_interfollicular_spinous	0.02	Nonsignificant	1.00	0.40	Other	260	563
113	T.CD4_transitional	0.02	Nonsignificant	0.83	1.02	Other	48	110
114	T.CD4_Tem	0.02	Nonsignificant	0.40	1.14	Other	365	697
115	FIB.lung_alveolar	0.01	Nonsignificant	—	0.00	Other	6	15
116	EPI.pancreatic_ductal_progenitor	0.01	Nonsignificant	1.00	0.40	Other	234	873
117	B.memory	0.01	Nonsignificant	1.00	0.69	Other	442	882
118	FIB.tracheal_subepithelial	0.01	Nonsignificant	—	0.00	Other	0	0
119	EPI.intrahepatic_cholangiocyte_transport	0.01	Nonsignificant	—	0.00	Other	12	42
120	MEL.melanocyte	0.01	Nonsignificant	—	—	Other	79	242
121	T.CD4_Treg	9.73e-03	Nonsignificant	1.00	0.83	Other	244	511
122	EC.lymphatic	9.37e-03	Nonsignificant	1.00	0.43	Other	630	998
123	GRNLSA.granulosa_cell	8.91e-03	Nonsignificant	—	—	Other	257	0
124	EPI.esophageal_basal	8.51e-03	Nonsignificant	1.00	0.36	Other	4	10
125	T.CD4_Th17	8.47e-03	Nonsignificant	0.56	1.08	Other	421	794
126	CHOND.chondrocyte	8.26e-03	Nonsignificant	—	—	Other	519	730
127	T.MAIT	8.23e-03	Nonsignificant	1.00	0.79	Other	469	855
128	EPI.skin_appendage_keratinocyte	6.93e-03	Nonsignificant	1.00	0.50	Other	87	222
129	T.CD8_Tcm	6.89e-03	Nonsignificant	0.83	0.99	Other	460	926
130	EPI.salivary_mucous_acinar	6.60e-03	Nonsignificant	1.00	0.29	Other	639	1,189
131	T.CD8_Tem	6.19e-03	Nonsignificant	0.22	1.11	Other	1,083	1,857
132	T.CD4_Tcm	6.11e-03	Nonsignificant	1.00	0.94	Other	494	988
133	FIB.transitioning	5.95e-03	Nonsignificant	1.00	0.20	Other	172	497
134	FIB.skin_tenogenic	5.93e-03	Nonsignificant	—	0.00	Other	108	227
135	FIB.barrier_secretory	5.82e-03	Nonsignificant	1.00	0.28	Other	81	228
136	FIB.skin_sheath	4.84e-03	Nonsignificant	1.00	0.14	Other	49	118
137	EPI.salivary_serous_acinar	4.78e-03	Nonsignificant	1.00	0.24	Other	233	531
138	NEU.INH_VIP	3.87e-03	Nonsignificant	1.00	0.18	Other	241	366
139	EPI.lung_club_secretory	3.07e-03	Nonsignificant	1.00	0.26	Other	5	14
140	SCHWN.schwann_cell	1.54e-03	Nonsignificant	—	—	Other	7	33
141	T.gamma_delta	1.47e-03	Nonsignificant	1.00	0.69	Other	588	1,078
142	FIB.neurolectin_mucosa	1.31e-03	Nonsignificant	1.00	0.05	Other	133	394
143	EPI.cervical_suprabasal	1.06e-03	Nonsignificant	—	0.00	Other	14	50
144	NEU.INH_LAMP5	9.75e-04	Nonsignificant	1.00	0.11	Other	263	532
145	EPI.tracheal_basal	9.62e-04	Nonsignificant	1.00	0.09	Other	398	1,120
146	EPI.tracheal_suprabasal	8.48e-04	Nonsignificant	1.00	0.22	Other	29	56
147	EPI.skin_sweat_duct_keratinocyte	6.91e-04	Nonsignificant	1.00	0.16	Other	146	301
148	EPI.ileal_goblet	4.95e-04	Nonsignificant	1.00	0.06	Other	181	432
149	T.CD4_cytotoxic	1.95e-04	Nonsignificant	1.00	0.31	Other	855	1,493
150	FIB.skin_papillary	1.61e-04	Nonsignificant	—	0.00	Other	0	0
151	EPI.thymic_cortical	1.51e-04	Nonsignificant	1.00	0.31	Other	442	824
152	DC.pDC	2.40e-05	Nonsignificant	1.00	0.00	Other	496	1,028

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	CM.mechano_activated	85.75	Significant	0.03	2.04	—	205	134
2	CM.anti_inflammatory	82.72	Significant	0.09	1.60	Specific	424	1,503
3	CM.mito_proteostasis	79.25	Significant	0.22	1.36	—	329	29
4	CM.sarcomere_actin_interface	78.30	Significant	0.22	1.37	—	450	78
5	CM.oxidative_phospho	76.41	Significant	0.80	0.99	Relevant	266	792
6	CM.translation_boost_RPL	72.84	Significant	1.00	0.71	—	129	1
7	CM.translation_boost_RPS	72.31	Significant	1.00	0.67	—	69	16
8	CM.osmoprotection	71.98	Significant	0.12	1.71	Relevant	34	57
9	CM.baseline	69.73	Significant	1.00	0.41	—	393	0
10	EC.liver_sinusoidal.remodeling_lipotoxicity	21.75	Significant	—	1.12	—	90	58
11	EC.liver_sinusoidal.inflammatory	20.15	Significant	—	0.80	—	223	154
12	CM.inflammatory	20.12	Significant	—	0.00	—	0	0
13	EPI.pancreatic_islet.beta	19.44	Significant	0.07	1.61	—	42	57
14	EC.heart_remodeling.perivascular	16.17	Significant	6.13e-04	2.26	Specific	124	408
15	EC.heart_remodeling.remodeling_stalk	15.84	Significant	0.01	2.00	Specific	33	111
16	EPI.renal_distal_tubule.ciliated_remodelling	15.36	Significant	—	1.64	Relevant	0	0
17	EC.liver_sinusoidal.hypoxia_metabolic	14.52	Significant	0.81	1.10	—	183	107
18	MESO.baseline	13.96	Significant	0.39	1.14	Relevant	0	6
19	EC.liver_sinusoidal.stress	13.16	Significant	—	0.11	—	413	158
20	EC.heart_remodeling.capillary_metabolic	12.90	Significant	0.22	1.53	Relevant	54	414
21	EC.heart_remodeling.activated_acute	12.02	Significant	0.70	1.04	Relevant	102	186
22	MESO.secretory_structural	11.32	Significant	—	0.47	Relevant	0	0
23	OLG.myelinating_stress	11.24	Significant	0.02	1.86	—	232	62
24	OLG.myelinating_mature	10.86	Significant	0.02	1.66	—	363	94
25	OLG.vesicle_trafficking	10.36	Significant	0.25	1.45	—	124	10
26	HEP.acute_phase.complement_antiviral	9.74	Significant	3.93e-03	1.90	Specific	377	751
27	FIB.adventitial.mechano_chemo_sensing	9.73	Significant	0.42	1.34	Relevant	135	524
28	EPI.pancreatic_islet.alpha	9.52	Significant	—	0.00	—	152	330
29	OLG.stress	9.48	Significant	0.62	1.11	—	232	8
30	OLG.regulatory_activated	9.45	Significant	0.82	0.92	Relevant	196	614
31	FIB.adventitial.mito_secretory	9.38	Significant	0.66	1.18	—	21	7
32	HEP.acute_phase.inflammatory	9.06	Significant	3.93e-03	1.86	Specific	382	649
33	OLG.regulatory	9.06	Significant	1.00	0.32	—	353	73
34	FIB.adventitial.baseline	8.84	Significant	0.72	0.92	Relevant	157	278
35	EC.heart_remodeling.angiocrine	8.75	Significant	1.00	0.33	Relevant	182	525
36	EC.heart_remodeling.remodeling_secretory	8.67	Significant	1.00	0.00	Relevant	605	1,341
37	EC.liver_sinusoidal.prostanoid	8.66	Significant	—	0.00	Relevant	11	64
38	FIB.adventitial.complement_angiocrine	8.54	Significant	0.42	1.32	Relevant	153	684
39	EC.heart_remodeling.translation_boost	8.05	Significant	—	0.00	—	0	0
40	MESO.antiviral	8.02	Significant	—	0.16	—	3	8
41	MESO.activated_migratory	7.13	Significant	—	0.00	Other	0	0
42	HEP.canalicular_transport.ductular_like_transition	7.09	Significant	2.23e-03	2.06	Specific	400	87
43	FIB.adventitial.inflammatory_activated	6.63	Significant	0.71	0.99	Other	100	473
44	FIB.adventitial.PI16_matrix	6.61	Significant	0.66	1.08	Relevant	70	90
45	FIB.adventitial.adhesion_lipid	6.17	Significant	0.93	0.60	Relevant	58	209
46	HEP.acute_phase.proliferative	5.95	Significant	—	0.25	Relevant	4	6
47	HEP.canalicular_transport.injury_stress	5.84	Significant	4.34e-03	1.91	Specific	289	24
48	OLG.reactive_repair	5.80	Significant	1.00	0.06	—	385	385
49	HEP.canalicular_transport.pericentral_like_hypoxia	5.77	Significant	0.54	1.17	Relevant	326	8
50	EC.liver_sinusoidal.secretory_lipoprotein	5.70	Significant	0.99	0.11	—	120	70
51	EPI.endocervical_secretory.secretory_translocon	5.63	Significant	—	0.67	Relevant	0	0
52	HEP.canalicular_transport.baseline	5.55	Significant	0.81	0.96	Relevant	199	477
53	HEP.periportal_metabolic.urea_onecarbon_secretory	5.21	Nominal	1.85e-06	2.08	Other	1,332	3,053
54	CM.contractile_oxphos	5.01	Nominal	1.00	0.00	Other	6	19
55	EC.arterial.arteriole_gas_exchange	4.72	Nominal	0.06	1.26	Other	238	131
56	HEP.acute_phase.baseline	4.69	Nominal	1.00	0.89	Other	946	19
57	HEP.canalicular_transport.inflammatory	4.40	Nominal	1.00	0.40	Other	1,335	194
58	EC.venous.cardiac_structural	4.36	Nominal	0.23	1.23	Other	102	229
59	HEP.acute_phase.hypoxia_lipid	4.19	Nominal	—	0.00	Other	0	0
60	EPI.pancreatic_islet.delta	4.14	Nominal	—	0.00	Other	0	0
61	MAC.alveolar.scavenging_endocytic	4.12	Nominal	—	1.28	Other	140	283
62	EPI.skin_sebaceous_duct_luminal.detox_repair	4.09	Nominal	0.50	1.39	Other	137	94
63	HEP.periportal_metabolic.xenobiotic_detox	4.03	Nominal	8.09e-03	1.66	Other	1,440	139
64	EPI.pancreatic_acinar.inflammatory_regenerative	4.00	Nominal	0.02	2.01	Other	25	113
65	FIB.hepatic_stellate_cell.inflammatory	3.93	Nominal	—	0.32	Other	0	0
66	FIB.hepatic_stellate_cell.contractile	3.88	Nominal	—	0.00	Other	0	0
67	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	3.77	Nominal	0.57	0.90	Other	2	9
68	HEP.periportal_metabolic.acute_phase_barrier	3.70	Nominal	0.95	0.72	Other	533	138
69	EC.arterial.arteriole_interface	3.63	Nominal	0.75	1.11	Other	31	12
70	MESO.activated_stress	3.61	Nominal	—	0.00	Other	0	0
71	HEP.acute_phase.complement_metabolic	3.56	Nominal	1.00	0.32	Other	1,423	3,464
72	HEP.periportal_metabolic.inflammatory_activated	3.54	Nominal	0.95	0.94	Other	712	1,610
73	EPI.pancreatic_acinar.baseline	3.54	Nominal	0.02	1.86	Other	274	163
74	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	3.48	Nominal	—	0.09	Other	0	0
75	FIB.hepatic_stellate_cell.fibrogenic	3.48	Nominal	—	0.00	Other	0	0
76	HEP.acute_phase.stress_secretory	3.46	Nominal	1.00	0.39	Other	26	3
77	HEP.canalicular_transport.sterol_lipid_biosynthesis	3.44	Nominal	—	0.00	Other	10	20
78	HEP.canalicular_transport.secretory_ERAD_UPR	3.42	Nominal	1.00	0.07	Other	232	28
79	EC.arterial.mito_contact	3.27	Nominal	0.75	1.09	Other	14	5
80	EPI.pancreatic_acinar.adhesion_remodeling	3.27	Nominal	0.22	1.48	Other	210	784
81	FIB.adventitial.activated_remodelling	3.20	Nominal	—	0.00	Other	141	319
82	EC.arterial.ion_pump	3.19	Nominal	1.00	0.85	Other	3	2
83	EPI.renal_distal_tubule.stress	3.07	Nominal	—	0.33	Other	0	0
84	EC.arterial.angiogenic_tip	3.03	Nominal	—	0.00	Other	30	37
85	EPI.renal_intercalated_cell_type_A.PC_transitional	3.00	Nonsignificant	—	0.66	Other	203	407
86	ASPC.mesothelial_like	2.99	Nonsignificant	0.20	1.45	Other	143	486
87	HEP.periportal_metabolic.stress_checkpoint	2.93	Nonsignificant	0.95	0.70	Other	234	786
88	EPI.pancreatic_acinar.quiet_dedifferentiation	2.90	Nonsignificant	0.64	0.98	Other	142	171
89	EC.arterial.inflammatory	2.89	Nonsignificant	1.00	0.99	Other	63	50
90	MAC.alveolar.biosynthetic_sterol_heme	2.88	Nonsignificant	0.68	1.13	Other	347	40
91	HEP.periportal_metabolic.canonical_urea_cycle	2.80	Nonsignificant	0.95	0.67	Other	1,464	269
92	EPI.ileal_enterocyte_crypt.baseline	2.72	Nonsignificant	0.18	1.34	Other	11	6
93	MAC.kupffer.monocyte_like	2.44	Nonsignificant	—	0.80	Other	0	0
94	HEP.periportal_metabolic.apolipoprotein_secretory	2.36	Nonsignificant	0.95	0.71	Other	43	110
95	EPI.pancreatic_acinar.metabolic_onecarbon	2.35	Nonsignificant	0.94	0.51	Other	287	328
96	EPI.ileal_enterocyte_crypt.proliferative_S	2.31	Nonsignificant	0.24	1.24	Other	4	2
97	EPI.skin_keratinocyte_proliferating.detox_repair	2.29	Nonsignificant	—	1.13	Other	0	0
98	EC.arterial.homeostatic	2.22	Nonsignificant	1.00	0.85	Other	24	3
99	MONO.CD14.cord_tolerance	2.17	Nonsignificant	0.36	1.10	Other	864	753
100	MAC.kupffer.inflammatory	2.13	Nonsignificant	—	0.64	Other	7	4
101	MAC.kupffer.tolerogenic	2.09	Nonsignificant	—	0.58	Other	45	49
102	SKM.type_1_slow.glycolytic	2.06	Nonsignificant	1.88e-04	2.68	Other	362	647
103	MAC.alveolar.capillary_interacting	2.05	Nonsignificant	0.62	1.34	Other	113	181
104	EPI.pancreatic_acinar.stress	2.05	Nonsignificant	0.64	0.97	Other	28	28
105	EPI.renal_distal_tubule.immune_modulatory	2.02	Nonsignificant	—	0.53	Other	0	0
106	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	2.02	Nonsignificant	—	0.98	Other	0	0
107	SKM.type_2_fast.oxidative_IIa	1.92	Nonsignificant	7.16e-07	2.92	Other	946	56
108	EPI.ileal_enterocyte_crypt.bile_transport	1.90	Nonsignificant	0.69	0.89	Other	2	0
109	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.84	Nonsignificant	—	0.00	Other	19	54
110	MAC.alveolar.lipid_autophagy	1.80	Nonsignificant	—	0.00	Other	35	44
111	EPI.skin_keratinocyte_basal.spinous_transition	1.79	Nonsignificant	—	0.97	Other	0	0
112	SMC.contractile	1.71	Nonsignificant	0.07	1.28	Other	80	588
113	EPI.skin_sebaceous_duct_luminal.immune_interface	1.68	Nonsignificant	—	0.00	Other	0	0
114	EPI.skin_keratinocyte_progenitor.activated_stress	1.63	Nonsignificant	—	0.38	Other	0	0
115	MAC.alveolar.stress_metabolic	1.59	Nonsignificant	0.90	0.84	Other	116	148
116	MAC.resident_cardiac.inflammatory_reparative	1.58	Nonsignificant	0.28	1.50	Other	31	96
117	SKM.type_1_slow.contractile	1.55	Nonsignificant	0.83	0.61	Other	596	8
118	EPI.skin_keratinocyte_basal.transit_amplifying	1.53	Nonsignificant	—	0.00	Other	0	0
119	SKM.type_1_slow.oxidative	1.53	Nonsignificant	0.83	0.59	Other	802	251
120	DC.cDC2.monocyte_like	1.52	Nonsignificant	0.02	1.55	Other	1,285	791
121	ASPC.signal_integrator	1.51	Nonsignificant	—	0.52	Other	0	0
122	EPI.colonic_tuft.homeostatic	1.47	Nonsignificant	—	0.73	Other	0	0
123	MAC.resident_cardiac.phagocytic_homeostasis	1.46	Nonsignificant	0.60	1.03	Other	564	1,221
124	EPI.ectocervical_granular.inflammatory	1.44	Nonsignificant	—	1.15	Other	0	0
125	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.41	Nonsignificant	0.68	0.76	Other	449	1,034
126	EPI.skin_hair_follicle_companion.gap_junction_contractile	1.40	Nonsignificant	—	0.97	Other	0	0
127	MAC.kupffer.stress	1.36	Nonsignificant	0.82	0.65	Other	9	3
128	EC.arterial.metabolic	1.36	Nonsignificant	1.00	0.88	Other	195	159
129	SKM.type_2_fast.glycolytic_IIx_IIb	1.35	Nonsignificant	1.00	0.00	Other	565	1,482
130	MAC.alveolar.inflammatory	1.35	Nonsignificant	0.90	0.64	Other	208	312
131	MAC.resident_cardiac.antigen_presenting	1.35	Nonsignificant	0.60	0.90	Other	52	27
132	EPI.renal_principal_cell.intercalated_like	1.32	Nonsignificant	7.69e-03	1.61	Other	63	66
133	MAC.kupffer.fibrogenic	1.21	Nonsignificant	—	0.00	Other	0	0
134	EPI.alveolar_type_2.injury_primed	1.17	Nonsignificant	2.52e-05	2.25	Other	434	245
135	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.14	Nonsignificant	—	0.00	Other	0	0
136	EPI.ileal_enterocyte_crypt.villus_transition	1.12	Nonsignificant	—	0.00	Other	7	10
137	EPI.colonic_enteroendocrine.Lcell_peptide	1.09	Nonsignificant	—	0.97	Other	0	0
138	DC.cDC2.tolerogenic_regulatory	1.05	Nonsignificant	0.33	1.29	Other	44	4
139	DC.cDC2.migratory	1.01	Nonsignificant	0.52	1.15	Other	185	39
140	EPI.ectocervical_granular.immune_interact	0.93	Nonsignificant	—	0.32	Other	0	0
141	DC.mig.baseline	0.93	Nonsignificant	—	0.00	Other	1	0
142	GRANU.neutrophil.tissue_patrolling	0.92	Nonsignificant	—	0.52	Other	0	0
143	ILC2.quiescent	0.90	Nonsignificant	—	0.35	Other	0	0
144	MAC.LAM.antimicrobial	0.90	Nonsignificant	0.43	1.24	Other	389	93
145	GRANU.neutrophil.primed_degranulation	0.88	Nonsignificant	—	0.00	Other	0	0
146	EC.capillary.inflammatory	0.88	Nonsignificant	0.10	1.15	Other	27	51
147	EPI.ectocervical_granular.proliferative_basal	0.87	Nonsignificant	—	0.00	Other	0	0
148	MAC.MDM.APC_dendritic	0.87	Nonsignificant	0.34	1.20	Other	48	15
149	PERI.cardiac_skeletal	0.85	Nonsignificant	6.03e-11	1.73	Other	313	630
150	EPI.salivary_duct_ion_transport.baseline	0.85	Nonsignificant	—	—	Other	0	0
151	DC.cDC2.pro_inflammatory	0.84	Nonsignificant	0.69	0.93	Other	3	5
152	MAC.LAM.inflammatory_APC	0.79	Nonsignificant	0.09	1.36	Other	872	165
153	EPI.salivary_intercalated_defense.inflammatory	0.78	Nonsignificant	0.75	1.06	Other	152	360
154	MAC.microglia_like.inflammatory_chemokine	0.77	Nonsignificant	—	0.52	Other	20	32
155	HEP.periportal_metabolic.stress_chaperone	0.76	Nonsignificant	—	0.00	Other	66	128
156	EPI.colonic_tuft.activated	0.76	Nonsignificant	—	0.00	Other	0	0
157	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.73	Nonsignificant	—	0.76	Other	2	0
158	EPI.salivary_duct_excretory.baseline	0.72	Nonsignificant	0.64	1.11	Other	23	57
159	MAC.resident_repair.lipid_phagocytic	0.71	Nonsignificant	0.68	1.18	Other	228	604
160	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.71	Nonsignificant	—	1.59	Other	0	0
161	MAC.proliferating.stress	0.71	Nonsignificant	—	0.15	Other	87	136
162	MAC.MDM.complement_resolving	0.70	Nonsignificant	0.02	1.53	Other	440	860
163	DC.cDC2.proliferative	0.70	Nonsignificant	—	0.12	Other	39	71
164	PC.IgG_systemic.secretory	0.69	Nonsignificant	7.71e-03	1.45	Other	0	0
165	EPI.salivary_duct_excretory.stress	0.68	Nonsignificant	0.64	0.79	Other	33	68
166	EPI.alveolar_type_2.stress_response	0.67	Nonsignificant	0.98	0.88	Other	675	1,562
167	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.65	Nonsignificant	—	0.00	Other	0	0
168	MAC.kupffer.metabolic	0.65	Nonsignificant	—	0.00	Other	25	36
169	PC.IgA_muocsal.migratory	0.64	Nonsignificant	0.47	1.07	Other	4	1
170	PC.IgA_muocsal.baseline	0.64	Nonsignificant	0.40	1.16	Other	3	5
171	GRANU.neutrophil.antiviral_endotoxin	0.63	Nonsignificant	—	0.00	Other	0	0
172	DC.cDC2.antiviral	0.63	Nonsignificant	0.53	1.08	Other	100	37
173	EPI.renal_intercalated_cell_type_A.acid_secretion	0.62	Nonsignificant	0.96	0.40	Other	12	6
174	B.germinal_center.LZ_survival	0.62	Nonsignificant	—	0.79	Other	0	0
175	SMC.metabolic	0.59	Nonsignificant	0.99	0.66	Other	14	40
176	EC.arterial.elastic	0.58	Nonsignificant	1.00	0.62	Other	22	45
177	EPI.lung_multiciliated.mature_motile_cilia	0.58	Nonsignificant	—	1.53	Other	0	0
178	MAC.resident_repair.chemokine_angiocrine	0.57	Nonsignificant	0.23	1.15	Other	87	138
179	EPI.colonocyte.proximal_transport	0.57	Nonsignificant	0.42	1.20	Other	24	12
180	B.germinal_center.LZ_memory_precursor	0.57	Nonsignificant	—	0.37	Other	0	0
181	FIB.interstitial.remodeling	0.56	Nonsignificant	0.19	1.21	Other	31	9
182	B.germinal_center.LZ_selection	0.55	Nonsignificant	—	0.73	Other	0	0
183	EPI.ileal_bile_transport.detox_transcytosis	0.55	Nonsignificant	—	0.20	Other	0	1
184	EPI.renal_immature_ureteric_bud.osmoprotective	0.54	Nonsignificant	0.02	1.32	Other	126	44
185	MAC.MDM.LAM_like	0.53	Nonsignificant	0.69	1.01	Other	12	14
186	EPI.esophageal_suprabasal.differentiating_keratin	0.52	Nonsignificant	2.52e-04	1.68	Other	131	61
187	NK.immature_bridge	0.52	Nonsignificant	0.45	1.06	Other	117	122
188	PC.IgA_muocsal.plasmablast	0.52	Nonsignificant	0.40	1.31	Other	5	4
189	HPC.GMP_granulocytic	0.52	Nonsignificant	—	0.20	Other	3	3
190	THYMO.proliferative_G2M	0.51	Nonsignificant	—	1.01	Other	164	413
191	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.50	Nonsignificant	0.75	0.78	Other	11	22
192	EC.capillary.stress	0.49	Nonsignificant	0.65	1.00	Other	44	36
193	PC.IgA_muocsal.activated	0.48	Nonsignificant	0.81	0.83	Other	17	8
194	MAC.LAM.lipid_opsonization	0.47	Nonsignificant	1.00	0.59	Other	45	14
195	MAC.MDM.inflammatory_phagocytic	0.47	Nonsignificant	0.76	0.86	Other	199	52
196	EPI.renal_thick_ascending_limb.barrier_repair	0.46	Nonsignificant	0.73	1.15	Other	141	284
197	SMC.activated	0.44	Nonsignificant	0.99	0.76	Other	2	5
198	EPI.ileal_bile_transport.absorptive_xenobiotic	0.44	Nonsignificant	0.72	0.59	Other	11	12
199	THYMO.SP_CD4_naive	0.43	Nonsignificant	0.03	1.55	Other	65	75
200	MAC.microglia_like.phagocytic_redox	0.43	Nonsignificant	—	0.17	Other	0	0
201	THYMO.DP_early	0.42	Nonsignificant	3.67e-04	1.62	Other	326	313
202	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.42	Nonsignificant	—	0.00	Other	0	0
203	EPI.ileal_enterocyte_crypt.secretory_precursor	0.41	Nonsignificant	—	0.00	Other	0	0
204	EPI.alveolar_type_2.baseline_surfactant	0.40	Nonsignificant	1.00	0.06	Other	64	9
205	EPI.gastric_foveolar.baseline	0.39	Nonsignificant	—	0.00	Other	0	0
206	FIB.suburothelial.urothelial_interface	0.38	Nonsignificant	2.34e-04	2.82	Other	9	8
207	MAC.LAM.anti_inflammatory	0.38	Nonsignificant	1.00	0.64	Other	86	132
208	MAC.proliferating.DNA_replication	0.36	Nonsignificant	0.83	0.73	Other	3	6
209	ASPC.baseline	0.34	Nonsignificant	9.02e-03	1.22	Other	363	170
210	EPI.ectocervical_granular.secretory_apocrine	0.34	Nonsignificant	—	0.00	Other	0	0
211	EC.capillary.activated	0.34	Nonsignificant	0.65	1.07	Other	2	5
212	HPC.GMP_inflammatory	0.34	Nonsignificant	0.36	1.26	Other	20	10
213	EPI.extrahepatic_cholangiocyte.barrier_interface	0.33	Nonsignificant	—	0.00	Other	0	0
214	FIB.interstitial.immune_interact	0.33	Nonsignificant	0.95	0.97	Other	12	1
215	PERI.angiocrine	0.32	Nonsignificant	1.00	0.69	Other	93	102
216	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.32	Nonsignificant	—	0.00	Other	0	0
217	MAC.LAM.perivascular_angiocrine	0.31	Nonsignificant	—	0.00	Other	53	138
218	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.31	Nonsignificant	—	0.00	Other	0	0
219	FIB.suburothelial.contractile_myofibroblast	0.29	Nonsignificant	—	0.00	Other	9	0
220	NK.cytokine_lung_immediate_early	0.29	Nonsignificant	1.00	1.04	Other	424	274
221	MAC.LAM.lipid_phagocytosis	0.28	Nonsignificant	1.00	0.18	Other	369	328
222	DC.cDC2.adhesion_signaling	0.28	Nonsignificant	1.00	0.42	Other	35	9
223	MAC.resident_iron.APC_iron_sensing	0.28	Nonsignificant	0.74	1.00	Other	211	114
224	DC.cDC1.baseline	0.27	Nonsignificant	—	1.53	Other	0	0
225	T.CD8_naive.mito_proteostasis	0.27	Nonsignificant	0.03	1.62	Other	428	100
226	EC.capillary.angiocrine	0.27	Nonsignificant	0.65	1.01	Other	250	630
227	FIB.suburothelial.inflammatory_prostanoid	0.27	Nonsignificant	—	0.00	Other	0	0
228	EPI.renal_thick_ascending_limb.remodeling	0.25	Nonsignificant	0.73	1.03	Other	152	92
229	EC.capillary.baseline	0.25	Nonsignificant	0.95	0.95	Other	246	560
230	MAC.resident_iron.heme_catabolism	0.24	Nonsignificant	0.74	1.11	Other	30	51
231	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.24	Nonsignificant	0.50	1.24	Other	40	191
232	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.23	Nonsignificant	—	0.00	Other	0	0
233	FIB.perivascular_interface.vascular_BM_remodelling	0.23	Nonsignificant	—	0.86	Other	0	0
234	NEU.EXC_CT.projector	0.22	Nonsignificant	0.11	1.35	Other	87	26
235	FIB.suburothelial.homeostasis_matrix	0.21	Nonsignificant	1.00	0.00	Other	258	921
236	THYMO.SP_CD8_naive	0.21	Nonsignificant	1.00	0.81	Other	297	177
237	EPI.endocervical_secretory.squamous_barrier	0.21	Nonsignificant	—	0.00	Other	0	0
238	NEU.EXC_SYT2.synaptic	0.21	Nonsignificant	—	0.48	Other	0	0
239	EPI.salivary_myoepithelial.contractile_repair	0.21	Nonsignificant	—	1.42	Other	3	9
240	NEU.EXC_IT.structural	0.20	Nonsignificant	0.62	1.16	Other	171	41
241	ASPC.inflammatory	0.20	Nonsignificant	0.63	1.19	Other	21	61
242	THYMO.SP_CD8_naive_stress	0.20	Nonsignificant	1.00	0.80	Other	1	1
243	HEP.pericentral_lipoprotein.ApoB_coagulation	0.20	Nonsignificant	—	0.67	Other	0	0
244	EPI.salivary_intercalated_defense.basal_EMT	0.20	Nonsignificant	—	0.00	Other	0	0
245	MAC.resident_repair.stress_iron	0.19	Nonsignificant	0.68	1.13	Other	48	97
246	ASPC.remodeling	0.19	Nonsignificant	1.00	0.95	Other	106	354
247	EPI.renal_thick_ascending_limb.cation_flux	0.18	Nonsignificant	0.73	1.04	Other	57	95
248	MAC.resident_iron.stress_tolerogenic	0.18	Nonsignificant	—	0.17	Other	0	0
249	EC.venous.remodeling_stalk	0.18	Nonsignificant	0.98	1.04	Other	559	566
250	THYMO.SP_CD8_transitional	0.18	Nonsignificant	1.00	0.73	Other	32	75
251	EC.capillary.migratory	0.18	Nonsignificant	0.65	1.02	Other	181	509
252	FIB.interstitial.stress_secretory	0.18	Nonsignificant	0.19	1.33	Other	92	56
253	EPI.ileal_enterocyte_absorptive.villus_tip	0.17	Nonsignificant	1.23e-04	1.75	Other	4	3
254	EPI.renal_principal_cell.inflammatory	0.17	Nonsignificant	0.94	0.84	Other	74	157
255	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.17	Nonsignificant	—	0.00	Other	135	290
256	EC.venous.baseline	0.17	Nonsignificant	0.98	0.94	Other	346	807
257	EPI.renal_principal_cell.canonical_vasopressin	0.17	Nonsignificant	0.94	1.03	Other	2	0
258	B.germinal_center.DZ_S_phase	0.16	Nonsignificant	—	0.00	Other	0	0
259	FIB.barrier_purinergic.lipid_secretory	0.16	Nonsignificant	—	0.48	Other	0	0
260	EC.lymphatic.valve	0.16	Nonsignificant	—	2.18	Other	0	0
261	DC.cDC2.lipid_metabolic	0.16	Nonsignificant	—	0.00	Other	0	0
262	ADIPO.immature	0.16	Nonsignificant	—	1.05	Other	24	40
263	FIB.perivascular_interface.vasomotor_tone	0.16	Nonsignificant	—	0.00	Other	0	0
264	HEP.pericentral_lipoprotein.UPR_redox	0.15	Nonsignificant	—	0.00	Other	0	0
265	PERI.baseline	0.15	Nonsignificant	1.00	0.44	Other	39	66
266	ASPC.secretory	0.15	Nonsignificant	1.00	0.95	Other	76	5
267	MUSC.baseline	0.15	Nonsignificant	0.43	1.21	Other	0	0
268	PERI.inflammatory	0.15	Nonsignificant	1.00	0.48	Other	40	77
269	MAC.resident_iron.redox_metabolic	0.14	Nonsignificant	0.80	0.75	Other	4	4
270	NEU.EXC_IT.guidance	0.14	Nonsignificant	0.54	1.23	Other	274	63
271	B.germinal_center.DZ_M_phase	0.13	Nonsignificant	—	0.00	Other	0	0
272	HPC.MEP	0.13	Nonsignificant	0.80	0.98	Other	599	1,195
273	EC.venous.quiescent_homeostatic	0.12	Nonsignificant	0.98	0.96	Other	456	360
274	NK.cytokine_tissue_activation	0.12	Nonsignificant	1.00	1.05	Other	267	450
275	MONO.CD16.hepatic_mac_like	0.12	Nonsignificant	0.33	1.12	Other	803	117
276	GRNLSA.angiocrine_mechanosensory	0.12	Nonsignificant	—	2.33	Other	0	0
277	MAC.resident_repair.antigen_presenting	0.11	Nonsignificant	0.89	0.96	Other	244	113
278	FIB.reticular.stromal_niche	0.11	Nonsignificant	0.11	1.31	Other	0	0
279	NEU.EXC_IT.neuromodulated	0.11	Nonsignificant	0.79	0.84	Other	176	116
280	MG.baseline	0.11	Nonsignificant	0.11	1.40	Other	16	5
281	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.11	Nonsignificant	—	0.00	Other	0	0
282	MUSC.activated_migratory	0.11	Nonsignificant	0.43	1.29	Other	6	7
283	NEU.EXC_CT.remodeling	0.11	Nonsignificant	—	0.38	Other	23	1
284	MONO.CD14.baseline	0.10	Nonsignificant	1.00	0.98	Other	2,268	76
285	MONO.CD14.inflammatory	0.10	Nonsignificant	1.00	1.06	Other	92	134
286	ASPC.adipocyte_capillary_interface	0.10	Nonsignificant	1.00	0.73	Other	21	54
287	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.10	Nonsignificant	—	0.35	Other	11	69
288	EPI.colonocyte.secretory_boost	0.10	Nonsignificant	1.00	1.00	Other	98	91
289	ASTRO.synaptic_interaction	0.10	Nonsignificant	0.59	1.08	Other	76	334
290	EPI.renal_principal_cell.injury_repair	0.09	Nonsignificant	0.94	0.52	Other	26	9
291	B.naive.baseline	0.09	Nonsignificant	0.24	1.32	Other	10	13
292	EPI.bile_duct_cholangiocyte.secretory_mucin	0.09	Nonsignificant	—	0.00	Other	7	12
293	FIB.skin_neurosecretory.baseline	0.09	Nonsignificant	—	0.00	Other	0	0
294	IPSC.proliferative	0.09	Nonsignificant	8.25e-03	1.07	Other	0	0
295	NEU.EXC_IT.adhesion	0.09	Nonsignificant	0.79	0.89	Other	252	108
296	THYMO.CD8aa_IELp	0.09	Nonsignificant	—	0.00	Other	1	7
297	GRANU.MAST.resting_granule	0.09	Nonsignificant	—	0.95	Other	0	0
298	EC.capillary.postcap_venule	0.09	Nonsignificant	0.65	1.01	Other	355	261
299	T.CD8_transitional.effector_primed	0.09	Nonsignificant	0.21	1.06	Other	435	151
300	MEL.neurotrophic_migratory	0.09	Nonsignificant	—	1.65	Other	0	0
301	ASTRO.hypoxia_angiogenic	0.08	Nonsignificant	0.59	1.23	Other	5	18
302	NEU.EXC_SYT2.nuclear_reg	0.08	Nonsignificant	—	0.00	Other	0	0
303	MONO.CD14.APC_like	0.08	Nonsignificant	1.00	0.97	Other	1,686	2,493
304	T.CD8_Trm.dendritic_recruiter	0.07	Nonsignificant	0.55	1.11	Other	47	85
305	PC.IgG_systemic.interacting	0.07	Nonsignificant	0.96	0.58	Other	0	0
306	EC.capillary.angiogenic_tip	0.07	Nonsignificant	0.96	0.81	Other	186	218
307	PC.IgG_systemic.stress	0.07	Nonsignificant	—	0.00	Other	1	5
308	EPI.skin_keratinocyte_basal.basement_anchoring	0.07	Nonsignificant	—	0.00	Other	0	0
309	EPI.pancreatic_ductal_perivascular.baseline	0.07	Nonsignificant	0.62	0.76	Other	1	5
310	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.07	Nonsignificant	0.19	1.29	Other	219	533
311	EPI.tracheal_submucosal_gland.acinar_serous	0.07	Nonsignificant	—	0.73	Other	0	0
312	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.07	Nonsignificant	—	0.00	Other	0	0
313	MAC.resident_iron.heme_recycling	0.07	Nonsignificant	—	0.00	Other	30	37
314	NEU.INH_PVALB.chandelier	0.07	Nonsignificant	0.36	1.32	Other	19	16
315	EPI.skin_hair_follicle_companion.activated_migratory	0.06	Nonsignificant	—	0.00	Other	0	0
316	ASPC.niche_keeping_progenitor	0.06	Nonsignificant	1.00	0.67	Other	52	219
317	EPI.thymic_medullary.hormone_xeno_barrier	0.06	Nonsignificant	—	0.95	Other	0	8
318	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.06	Nonsignificant	—	0.73	Other	5	3
319	NEU.EXC_NTNG1.synaptic	0.06	Nonsignificant	—	0.67	Other	0	0
320	HPC.MPP_IEG	0.06	Nonsignificant	0.80	1.05	Other	45	46
321	MONO.CD14.platelet_bound	0.06	Nonsignificant	1.00	0.98	Other	964	176
322	MAC.resident_repair.ECM_stromal_crosstalk	0.06	Nonsignificant	0.98	0.69	Other	95	158
323	ASPC.proliferative	0.06	Nonsignificant	1.00	0.65	Other	33	85
324	T.CD4_naive.neddylation_mitoprot	0.06	Nonsignificant	0.40	1.29	Other	93	56
325	EPI.skin_interfollicular_spinous.inflammatory	0.06	Nonsignificant	—	0.91	Other	0	0
326	IPSC.mesendo_primed	0.06	Nonsignificant	1.86e-04	1.11	Other	0	0
327	EPI.renal_principal_cell.activated_acute	0.06	Nonsignificant	0.94	0.47	Other	29	59
328	PC.IgG_systemic.metabolic	0.06	Nonsignificant	0.96	0.44	Other	46	63
329	FIB.interstitial.mesenchymal_regulator	0.06	Nonsignificant	0.95	0.71	Other	4	4
330	FIB.perivascular_interface.lipid_shuttle	0.06	Nonsignificant	—	0.00	Other	51	170
331	HPC.LMPP	0.06	Nonsignificant	0.92	0.69	Other	65	31
332	EPI.pancreatic_ductal_bicarbonate.baseline	0.05	Nonsignificant	0.93	1.00	Other	11	42
333	ASPC.preadipocyte_lipid_primed	0.05	Nonsignificant	1.00	0.54	Other	331	129
334	FIB.interstitial.mesenchymal_APC	0.05	Nonsignificant	0.95	0.88	Other	81	33
335	B.naive.metabolic	0.05	Nonsignificant	0.76	1.12	Other	50	79
336	THYMO.DP_early_stress	0.05	Nonsignificant	—	0.00	Other	0	0
337	FIB.interstitial.lipid_matrix	0.05	Nonsignificant	0.95	0.77	Other	258	191
338	T.CD4_Tfh.suppression_exhaustion	0.05	Nonsignificant	0.67	1.13	Other	0	2
339	EPI.esophageal_suprabasal.proliferative_S	0.05	Nonsignificant	—	0.00	Other	26	41
340	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.05	Nonsignificant	—	1.39	Other	39	82
341	T.CD8_transitional.APC_like	0.05	Nonsignificant	0.21	1.06	Other	205	62
342	T.CD8_Trm.inflammatory	0.05	Nonsignificant	0.15	1.17	Other	124	176
343	EPI.esophageal_suprabasal.proliferative_exit	0.05	Nonsignificant	—	0.00	Other	0	0
344	NEU.INH_PVALB.metabotropic	0.05	Nonsignificant	—	0.63	Other	0	0
345	T.CD4_Trm.baseline	0.05	Nonsignificant	0.74	1.10	Other	31	21
346	T.CD8_transitional.Trm_primed	0.04	Nonsignificant	0.69	1.01	Other	108	15
347	T.CD4_Tfh.canonical_GC_helper	0.04	Nonsignificant	0.81	1.00	Other	1	2
348	MONO.CD16.platelet_bound	0.04	Nonsignificant	0.33	1.24	Other	372	508
349	MUSC.quiescent_reservoir	0.04	Nonsignificant	0.89	0.65	Other	2	8
350	MUSC.early_activation	0.04	Nonsignificant	0.89	0.62	Other	4	32
351	T.CD4_Tfh.effector_migratory	0.04	Nonsignificant	0.12	1.25	Other	122	57
352	EPI.esophageal_suprabasal.proliferative_G2M	0.04	Nonsignificant	—	0.00	Other	0	0
353	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.04	Nonsignificant	—	0.00	Other	0	0
354	T.CD4_Treg.tissue_effector	0.04	Nonsignificant	0.14	1.45	Other	16	13
355	NEU.EXC_NTNG1.nuclear_reg	0.04	Nonsignificant	—	0.00	Other	0	0
356	EPI.thymic_medullary.stress_APC	0.04	Nonsignificant	0.76	1.13	Other	2	4
357	T.CD4_transitional.primed_helper_effector	0.04	Nonsignificant	0.24	1.21	Other	19	43
358	EPI.pancreatic_ductal_progenitor.ADM_like	0.04	Nonsignificant	—	1.55	Other	0	0
359	EPI.skin_follicular_keratinizing.root_infundibulum	0.04	Nonsignificant	—	0.49	Other	0	0
360	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.04	Nonsignificant	6.18e-03	2.09	Other	58	89
361	NEU.EXC_IT.transitional	0.04	Nonsignificant	0.79	0.83	Other	237	142
362	EPI.hepatic_ductular_cholangiocyte.stress	0.04	Nonsignificant	—	0.58	Other	0	0
363	EPI.alveolar_type_1.baseline	0.04	Nonsignificant	0.11	1.76	Other	8	0
364	B.naive.receptor_recycle	0.04	Nonsignificant	0.76	1.03	Other	51	0
365	EPI.skin_interfollicular_spinous.stress_oxidative	0.04	Nonsignificant	—	0.79	Other	0	0
366	PLAT.adhesion	0.04	Nonsignificant	—	0.48	Other	0	0
367	T.CD4_Trm.central_like	0.04	Nonsignificant	0.03	1.23	Other	38	31
368	NEU.EXC_IT.callosal	0.04	Nonsignificant	0.79	0.97	Other	286	119
369	EPI.skin_interfollicular_spinous.proliferative	0.04	Nonsignificant	—	1.01	Other	0	0
370	EPI.renal_distal_tubule.repair	0.04	Nonsignificant	—	0.00	Other	34	102
371	MONO.CD14.repair_M2_like	0.04	Nonsignificant	1.00	0.88	Other	550	1,495
372	OPC.homeostatic	0.03	Nonsignificant	0.07	1.36	Other	394	160
373	MG.phagocytic_APC	0.03	Nonsignificant	0.95	0.39	Other	25	8
374	B.memory.migratory	0.03	Nonsignificant	0.54	1.16	Other	123	208
375	T.CD4_naive.homeostatic	0.03	Nonsignificant	0.40	1.19	Other	215	108
376	IPSC.canonical_pluripotent	0.03	Nonsignificant	0.25	1.04	Other	0	0
377	THYMO.proliferative_S	0.03	Nonsignificant	1.00	0.03	Other	163	418
378	IPSC.endoderm_primed	0.03	Nonsignificant	1.00	0.99	Other	0	0
379	CHOND.remodeling	0.03	Nonsignificant	—	1.11	Other	5	0
380	GRANU.MAST.activated_acute	0.03	Nonsignificant	—	0.00	Other	0	0
381	IPSC.mesodermal_primed	0.03	Nonsignificant	1.00	0.93	Other	0	0
382	GRNLSA.chemokine_mechanosensory	0.03	Nonsignificant	0.68	1.31	Other	1	0
383	T.CD4_naive.proteostasis_mitoprot	0.03	Nonsignificant	0.40	1.22	Other	15	37
384	EPI.renal_immature_ureteric_bud.defense_secretory	0.03	Nonsignificant	1.00	0.12	Other	45	76
385	EPI.skin_hair_follicle_bulge.quiescent	0.03	Nonsignificant	0.29	1.20	Other	56	69
386	T.CD8_naive.baseline	0.03	Nonsignificant	0.88	1.13	Other	142	2
387	B.naive.proteostasis	0.03	Nonsignificant	0.76	1.05	Other	49	69
388	FIB.lung_alveolar.stress_interacting	0.03	Nonsignificant	—	0.97	Other	0	0
389	GRANU.MAST.activated_repair	0.03	Nonsignificant	—	0.00	Other	0	1
390	EPI.colonocyte.crypt_progenitor	0.03	Nonsignificant	1.00	0.81	Other	115	265
391	B.naive.purinergic	0.03	Nonsignificant	0.76	0.93	Other	384	820
392	HPC.CLP_B_primed	0.03	Nonsignificant	—	0.07	Other	0	0
393	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.03	Nonsignificant	—	0.00	Other	0	0
394	EPI.alveolar_type_1.activated	0.03	Nonsignificant	—	0.00	Other	0	0
395	T.CD4_Tcm.DC_interact	0.03	Nonsignificant	0.38	1.22	Other	72	32
396	NEU.INH_VIP.enkephalinergic	0.03	Nonsignificant	—	1.68	Other	0	0
397	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.03	Nonsignificant	—	0.00	Other	29	88
398	EPI.renal_distal_tubule.ion_transport	0.02	Nonsignificant	—	0.00	Other	0	0
399	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.02	Nonsignificant	—	0.00	Other	0	0
400	PLAT.megakaryocytic	0.02	Nonsignificant	—	0.00	Other	0	0
401	T.CD4_naive.survival_mitoprot	0.02	Nonsignificant	0.40	1.22	Other	13	7
402	MG.expanding	0.02	Nonsignificant	0.95	0.39	Other	2	1
403	T.CD8_Tcm.effector_bias	0.02	Nonsignificant	0.52	1.26	Other	199	329
404	EPI.skin_interfollicular_spinous.transition_basal	0.02	Nonsignificant	0.74	1.18	Other	100	127
405	EPI.renal_proximal_tubule.detox_antioxidant	0.02	Nonsignificant	1.00	0.00	Other	394	77
406	T.CD4_naive.proteostasis	0.02	Nonsignificant	0.71	1.06	Other	14	9
407	DC.cDC1.activated	0.02	Nonsignificant	—	0.52	Other	0	0
408	B.age_associated.migratory	0.02	Nonsignificant	0.24	1.26	Other	2	2
409	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.02	Nonsignificant	—	0.00	Other	6	9
410	ASPC.activated	0.02	Nonsignificant	1.00	0.42	Other	164	162
411	ILC2.migratory	0.02	Nonsignificant	—	0.00	Other	0	0
412	EC.venous.activated	0.02	Nonsignificant	0.98	0.84	Other	247	752
413	EPI.thymic_medullary.canonical_alarmin	0.02	Nonsignificant	0.97	0.24	Other	8	17
414	EPI.tracheal_submucosal_gland.ductal_luminal	0.02	Nonsignificant	—	0.00	Other	0	0
415	B.naive.antigen_presenting_ready	0.02	Nonsignificant	0.76	0.91	Other	48	73
416	T.CD4_transitional.APC_interacting	0.02	Nonsignificant	0.67	0.99	Other	10	14
417	T.CD8_naive.cytokine_dampened	0.02	Nonsignificant	0.90	0.81	Other	71	4
418	B.naive.remodeling	0.02	Nonsignificant	0.76	0.88	Other	135	230
419	B.naive.restrained	0.02	Nonsignificant	0.09	1.27	Other	183	353
420	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.02	Nonsignificant	—	0.70	Other	105	368
421	IPSC.axial_identity_primed	0.02	Nonsignificant	1.00	0.96	Other	0	0
422	T.MAIT.migratory	0.02	Nonsignificant	0.02	1.55	Other	10	1
423	HPC.MPP_activated	0.02	Nonsignificant	—	0.00	Other	0	0
424	T.CD8_Tem.early_helper_like	0.02	Nonsignificant	0.55	1.13	Other	445	755
425	T.CD4_naive.survival	0.02	Nonsignificant	0.71	1.05	Other	12	17
426	T.CD4_naive.gut_prone	0.02	Nonsignificant	0.71	1.07	Other	35	70
427	T.CD8_naive.nfkb_related	0.02	Nonsignificant	0.88	0.97	Other	1	0
428	T.CD4_Tem.inflammatory	0.02	Nonsignificant	0.76	1.03	Other	28	6
429	T.CD8_transitional.stress	0.02	Nonsignificant	—	0.86	Other	24	34
430	T.CD4_Th2.precursor	0.02	Nonsignificant	—	0.00	Other	0	0
431	EPI.renal_intercalated_cell_type_B.baseline	0.02	Nonsignificant	—	0.00	Other	3	1
432	B.naive.activated	0.02	Nonsignificant	0.76	0.90	Other	77	127
433	EPI.lung_multiciliated.baseline	0.02	Nonsignificant	—	0.51	Other	0	7
434	EPI.thymic_medullary.proliferative_APC	0.02	Nonsignificant	—	0.00	Other	0	0
435	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.02	Nonsignificant	0.93	0.82	Other	14	32
436	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.02	Nonsignificant	1.00	0.29	Other	322	317
437	T.CD4_naive.survival_neddylation	0.02	Nonsignificant	0.71	1.06	Other	26	38
438	T.CD4_transitional.primed_cytotoxic	0.02	Nonsignificant	0.67	1.09	Other	28	30
439	T.CD8_naive.innate_like	0.02	Nonsignificant	0.88	1.06	Other	10	1
440	T.CD4_Th17.migratory	0.02	Nonsignificant	0.10	1.20	Other	13	23
441	NEU.INH_PVALB.fastspike	0.02	Nonsignificant	—	0.00	Other	24	22
442	EPI.skin_follicular_keratinizing.upper_infundibulum	0.02	Nonsignificant	—	0.14	Other	8	2
443	T.CD4_Th2.tissue_adapted	0.02	Nonsignificant	—	0.00	Other	0	0
444	MAC.microglia_like.patrolling_adhesive	0.02	Nonsignificant	—	0.00	Other	0	0
445	DC.cDC1.cross_presenting	0.02	Nonsignificant	—	0.17	Other	0	0
446	T.CD4_Trm.activated	0.02	Nonsignificant	0.84	1.07	Other	32	26
447	T.CD4_naive.mature	0.02	Nonsignificant	0.77	0.95	Other	211	100
448	EPI.esophageal_suprabasal.basal_transitional	0.02	Nonsignificant	1.00	0.00	Other	44	67
449	CHOND.articular_collagen	0.02	Nonsignificant	0.14	1.16	Other	551	266
450	NEU.EXC_CT.Ca2_signaling	0.02	Nonsignificant	—	0.00	Other	68	17
451	EPI.ileal_enterocyte_absorptive.brush_border	0.02	Nonsignificant	1.00	0.00	Other	580	1,717
452	T.CD8_naive.lipid_synthesis	0.02	Nonsignificant	0.88	1.04	Other	6	4
453	FIB.reticular.stress_metallothionein	0.02	Nonsignificant	—	0.00	Other	3	32
454	T.CD8_naive.vesicle_secretory	0.02	Nonsignificant	0.88	0.91	Other	42	0
455	EPI.skin_follicular_keratinizing.transit_amplifying	0.02	Nonsignificant	—	0.00	Other	21	49
456	FIB.transitioning.motility_remodelling	0.02	Nonsignificant	—	0.92	Other	0	0
457	T.CD4_Tem.long_term_memory	0.02	Nonsignificant	0.76	1.05	Other	314	587
458	EPI.renal_thick_ascending_limb.salt_sensing	0.01	Nonsignificant	1.00	0.47	Other	73	103
459	B.age_associated.activated	0.01	Nonsignificant	—	0.00	Other	18	22
460	T.CD8_naive.effector_transition	0.01	Nonsignificant	0.88	0.88	Other	35	62
461	B.age_associated.naive_transitional	0.01	Nonsignificant	—	0.00	Other	0	0
462	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.01	Nonsignificant	—	0.00	Other	0	0
463	NEU.INH_PVALB.neuromodulatory	0.01	Nonsignificant	—	0.00	Other	0	0
464	T.CD4_naive.mature_mitoprot	0.01	Nonsignificant	0.81	0.90	Other	212	476
465	T.CD4_Tem.cytotoxic_effector	0.01	Nonsignificant	0.83	0.95	Other	225	398
466	MONO.CD14.remodeling	0.01	Nonsignificant	1.00	0.94	Other	2,373	295
467	FIB.skin_sheath.neuro_vascular_interface	0.01	Nonsignificant	—	1.03	Other	0	0
468	T.CD4_Tem.transitional_CM	0.01	Nonsignificant	0.83	0.92	Other	31	20
469	T.CD4_Tcm.tissue_homing	0.01	Nonsignificant	0.69	1.18	Other	78	46
470	EC.venous.adipose_lipid	0.01	Nonsignificant	0.98	0.76	Other	254	476
471	MEL.dedifferentiated_migratory	0.01	Nonsignificant	—	0.37	Other	0	0
472	T.CD4_naive.resist_bystander	0.01	Nonsignificant	0.77	0.93	Other	40	25
473	CHOND.angiogenic	0.01	Nonsignificant	—	0.92	Other	0	0
474	T.CD8_Tem.baseline	0.01	Nonsignificant	0.55	1.10	Other	458	356
475	T.CD4_naive.neddylation	0.01	Nonsignificant	0.81	0.86	Other	104	222
476	ILC2.activated	0.01	Nonsignificant	—	6.94e-17	Other	0	0
477	T.CD4_Trm.helper_like	0.01	Nonsignificant	0.84	0.96	Other	84	147
478	FIB.tracheal_subepithelial.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
479	THYMO.DN_preTCR	0.01	Nonsignificant	1.00	0.02	Other	41	71
480	T.CD4_Trm.cytotoxic_effector	0.01	Nonsignificant	0.84	1.02	Other	118	77
481	EPI.esophageal_basal.activated_progenitor	0.01	Nonsignificant	0.08	1.54	Other	1	0
482	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	1.04	Other	1	9
483	T.MAIT.early_activation	0.01	Nonsignificant	0.60	1.22	Other	57	4
484	T.CD4_transitional.tissue_enagement	0.01	Nonsignificant	0.67	1.06	Other	5	11
485	EPI.skin_interfollicular_spinous.early_differentiation	0.01	Nonsignificant	0.74	1.04	Other	89	19
486	B.memory.activated	0.01	Nonsignificant	0.85	1.02	Other	105	29
487	NEU.INH_VIP.cannabinoid	0.01	Nonsignificant	—	0.60	Other	0	0
488	OPC.proliferative_immune_interact	0.01	Nonsignificant	0.97	0.70	Other	180	373
489	EPI.pancreatic_ductal_progenitor.baseline	9.95e-03	Nonsignificant	0.98	0.35	Other	179	702
490	EPI.colonic_enteroendocrine.progenitor	9.73e-03	Nonsignificant	—	0.00	Other	0	0
491	T.CD4_Tcm.effector_like	9.40e-03	Nonsignificant	0.79	1.09	Other	293	533
492	NK.adaptive_classII_inhibitory	9.18e-03	Nonsignificant	1.00	1.00	Other	880	154
493	NK.cytokine_repair_primed	9.17e-03	Nonsignificant	1.00	1.05	Other	266	11
494	T.CD8_Trm.muscosal_Tc17	9.16e-03	Nonsignificant	1.00	0.86	Other	19	38
495	T.CD4_naive.purinergic	8.95e-03	Nonsignificant	0.77	0.93	Other	49	1
496	T.CD4_Tcm.imprinted_splicing	8.80e-03	Nonsignificant	0.79	1.12	Other	6	17
497	NK.cytokine_tissue_resident	8.69e-03	Nonsignificant	1.00	0.98	Other	74	82
498	NEU.INH_VIP.serotonergic	8.60e-03	Nonsignificant	—	0.56	Other	9	2
499	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	8.56e-03	Nonsignificant	—	0.32	Other	0	0
500	OPC.premyelinating	8.53e-03	Nonsignificant	0.97	0.57	Other	185	12
501	NEU.EXC_CT.Ca2_sensor	8.23e-03	Nonsignificant	—	0.00	Other	0	0
502	B.memory.baseline	8.22e-03	Nonsignificant	0.85	0.93	Other	472	99
503	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	8.07e-03	Nonsignificant	—	0.00	Other	0	0
504	T.CD8_Trm.homeostatic	7.92e-03	Nonsignificant	1.00	0.77	Other	42	5
505	NEU.INH_PVALB.serotonergic	7.81e-03	Nonsignificant	—	0.00	Other	0	0
506	EPI.hepatic_ductular_cholangiocyte.polarity	7.72e-03	Nonsignificant	—	0.00	Other	0	0
507	MEL.secretory_quiescent	7.71e-03	Nonsignificant	0.99	0.88	Other	19	13
508	T.CD4_Tcm.crosstalk_myeloid	7.71e-03	Nonsignificant	0.79	1.17	Other	5	4
509	EPI.lung_multiciliated.stress	7.59e-03	Nonsignificant	—	0.00	Other	67	165
510	FIB.barrier_secretory.homeostasis	7.56e-03	Nonsignificant	—	0.00	Other	0	0
511	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	7.48e-03	Nonsignificant	—	0.00	Other	0	0
512	FIB.transitioning.matrix_stress	7.45e-03	Nonsignificant	—	0.00	Other	47	138
513	T.CD8_Tcm.NK_like	7.34e-03	Nonsignificant	0.58	1.22	Other	334	581
514	T.CD8_naive.splicing_enriched	7.33e-03	Nonsignificant	0.99	0.58	Other	120	16
515	T.CD4_Treg.APC_interactive	7.16e-03	Nonsignificant	0.74	1.03	Other	118	28
516	EPI.salivary_serous_acinar.seromucous_like	7.15e-03	Nonsignificant	—	0.48	Other	0	0
517	B.memory.pDC_imprint	7.09e-03	Nonsignificant	0.85	0.93	Other	157	103
518	T.CD8_transitional.early	7.04e-03	Nonsignificant	1.00	0.80	Other	327	55
519	T.CD4_Th17.baseline	6.94e-03	Nonsignificant	0.71	1.02	Other	51	5
520	T.CD4_Tfh.precursor_migratory	6.82e-03	Nonsignificant	0.98	0.64	Other	72	27
521	ASTRO.neuromodulatory	6.70e-03	Nonsignificant	0.98	0.94	Other	34	172
522	EPI.salivary_mucous_acinar.baseline	6.60e-03	Nonsignificant	—	—	Other	394	683
523	T.MAIT.vesicle	6.57e-03	Nonsignificant	0.98	0.84	Other	37	65
524	ADIPO.thermogenic	6.55e-03	Nonsignificant	—	0.14	Other	0	0
525	EPI.lung_club_secretory.canonical_surfactant	6.34e-03	Nonsignificant	—	0.75	Other	74	104
526	GRNLSA.lipid_hypoxia	6.32e-03	Nonsignificant	0.86	1.02	Other	28	0
527	IPSC.stress	6.26e-03	Nonsignificant	0.69	1.05	Other	0	0
528	EPI.skin_interfollicular_spinous.baseline	5.98e-03	Nonsignificant	0.92	0.59	Other	35	3
529	T.CD4_transitional.baseline	5.98e-03	Nonsignificant	0.67	0.97	Other	59	97
530	GRNLSA.EMT_insulin_signaling	5.98e-03	Nonsignificant	0.86	0.96	Other	47	84
531	T.CD4_naive.Treg_like	5.98e-03	Nonsignificant	0.77	0.90	Other	121	72
532	FIB.lung_alveolar.mito_secretory	5.95e-03	Nonsignificant	—	0.00	Other	0	0
533	FIB.skin_tenogenic.baseline	5.93e-03	Nonsignificant	—	0.00	Other	0	2
534	EPI.pancreatic_ductal_bicarbonate.activated	5.91e-03	Nonsignificant	0.95	0.56	Other	10	7
535	FIB.reticular.ECM_builder	5.83e-03	Nonsignificant	—	0.00	Other	0	0
536	EC.lymphatic.baseline	5.82e-03	Nonsignificant	0.83	1.15	Other	38	72
537	EPI.colonocyte.distal_absorptive	5.60e-03	Nonsignificant	—	0.04	Other	0	0
538	FIB.reticular.immune_interface	5.25e-03	Nonsignificant	—	0.00	Other	1	6
539	T.CD8_Tcm.baseline	5.22e-03	Nonsignificant	0.64	1.06	Other	90	89
540	B.memory.preactivated	5.20e-03	Nonsignificant	0.85	0.82	Other	173	174
541	T.MAIT.MAPK_brake	5.11e-03	Nonsignificant	0.98	0.70	Other	44	66
542	GRNLSA.cholesterol_mevalonate	5.08e-03	Nonsignificant	0.86	1.00	Other	9	4
543	EPI.salivary_serous_acinar.secretory_active	4.95e-03	Nonsignificant	0.85	1.04	Other	242	69
544	IPSC.neural_primed	4.93e-03	Nonsignificant	1.00	0.85	Other	0	0
545	T.CD4_Tcm.migratory_cilium	4.91e-03	Nonsignificant	0.88	1.04	Other	5	10
546	T.MAIT.quiescent	4.89e-03	Nonsignificant	0.98	0.54	Other	100	5
547	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	4.83e-03	Nonsignificant	—	0.00	Other	49	237
548	T.CD4_naive.activated_stress	4.39e-03	Nonsignificant	0.40	1.36	Other	339	429
549	NEU.INH_PVALB.nuclear_reg	4.26e-03	Nonsignificant	1.00	0.00	Other	25	12
550	ASPC.stem_like_progenitor	4.25e-03	Nonsignificant	1.00	0.20	Other	300	842
551	MEL.stress_glucocorticoid	4.23e-03	Nonsignificant	0.99	0.81	Other	11	34
552	EPI.skin_interfollicular_spinous.stress_UPR	3.94e-03	Nonsignificant	—	0.00	Other	0	0
553	T.CD4_Tcm.APC_mimicry	3.94e-03	Nonsignificant	0.88	1.04	Other	54	43
554	T.MAIT.cytotoxic	3.93e-03	Nonsignificant	0.98	0.68	Other	52	15
555	EC.lymphatic.scavenger	3.86e-03	Nonsignificant	0.83	0.65	Other	203	257
556	EPI.skin_interfollicular_spinous.upper_lipid	3.65e-03	Nonsignificant	—	0.00	Other	6	6
557	EPI.skin_appendage_keratinocyte.transit_amplifying	3.50e-03	Nonsignificant	—	0.00	Other	109	358
558	EPI.salivary_myoepithelial.junctional_transport	3.46e-03	Nonsignificant	1.00	1.10	Other	66	121
559	EPI.ileal_goblet.immature	3.45e-03	Nonsignificant	—	1.13	Other	0	0
560	EC.lymphatic.activated	3.42e-03	Nonsignificant	0.83	0.77	Other	47	73
561	FIB.barrier_secretory.remodeling	3.41e-03	Nonsignificant	—	0.00	Other	0	0
562	SCHWN.translation_boost	3.40e-03	Nonsignificant	—	0.27	Other	8	1
563	T.CD4_Tcm.Tfh_like	3.29e-03	Nonsignificant	0.91	0.97	Other	102	214
564	IPSC.neuroendocrine_primed	3.21e-03	Nonsignificant	—	0.80	Other	0	0
565	T.CD4_Th17.cytotoxic	3.12e-03	Nonsignificant	0.75	0.93	Other	332	123
566	DC.cDC1.proliferative	3.12e-03	Nonsignificant	—	0.00	Other	0	0
567	EC.lymphatic.tip_migratory	3.09e-03	Nonsignificant	0.83	0.71	Other	23	37
568	T.CD4_Treg.Tr1_like	2.94e-03	Nonsignificant	—	0.00	Other	8	8
569	FIB.transitioning.secretory_procollagen	2.92e-03	Nonsignificant	—	0.00	Other	0	0
570	CHOND.activated_fibro_like	2.90e-03	Nonsignificant	1.00	0.73	Other	531	188
571	ASTRO.stress_mito	2.82e-03	Nonsignificant	0.96	1.07	Other	47	110
572	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	2.82e-03	Nonsignificant	—	1.24	Other	0	0
573	T.CD4_Tcm.Th2_like	2.50e-03	Nonsignificant	0.69	1.24	Other	23	55
574	ADIPO.hypoxia_remodelling	2.45e-03	Nonsignificant	—	0.00	Other	29	105
575	FIB.neurolectin_mucosa.nerve_interface	2.40e-03	Nonsignificant	—	0.75	Other	4	0
576	NK.adaptive_HLAE_tuned	2.33e-03	Nonsignificant	1.00	0.98	Other	1,124	189
577	EPI.skin_hair_follicle_bulge.anagen_growth	2.28e-03	Nonsignificant	—	0.00	Other	0	0
578	ASTRO.homeostatic	2.25e-03	Nonsignificant	0.96	1.03	Other	200	431
579	FIB.neurolectin_mucosa.remodeling_repair	2.24e-03	Nonsignificant	—	0.15	Other	4	2
580	NEU.INH_VIP.canonical_disinhibitory	2.22e-03	Nonsignificant	0.26	1.24	Other	59	38
581	EPI.salivary_serous_acinar.quiescent	2.11e-03	Nonsignificant	0.86	0.78	Other	178	493
582	EPI.lung_club_secretory.ciliogenesis_primed	2.11e-03	Nonsignificant	—	0.37	Other	0	0
583	NEU.INH_VIP.nuclear_reg	2.09e-03	Nonsignificant	—	0.30	Other	20	4
584	T.CD8_Trm.cytotoxic	2.08e-03	Nonsignificant	1.00	0.45	Other	165	85
585	EPI.hepatic_ductular_cholangiocyte.secretory_transport	2.06e-03	Nonsignificant	—	0.00	Other	0	0
586	EPI.colonocyte.ionocyte_BEST4	2.02e-03	Nonsignificant	1.00	0.68	Other	103	188
587	NEU.INH_VIP.regulatory_remodeling	2.02e-03	Nonsignificant	—	0.16	Other	6	1
588	EPI.esophageal_basal.junctional_barrier	1.95e-03	Nonsignificant	—	0.00	Other	0	0
589	GRNLSA.p53_damage	1.94e-03	Nonsignificant	—	0.12	Other	13	10
590	T.gamma_delta.early_effector	1.89e-03	Nonsignificant	0.43	1.09	Other	89	0
591	FIB.skin_sheath.stress_chaperone	1.81e-03	Nonsignificant	—	0.00	Other	0	0
592	NEU.INH_LAMP5.rosehip	1.81e-03	Nonsignificant	—	0.46	Other	0	0
593	T.CD4_Trm.stress_adaptive	1.80e-03	Nonsignificant	0.91	0.86	Other	8	22
594	T.gamma_delta.cytotoxic_effector	1.77e-03	Nonsignificant	0.74	1.02	Other	349	109
595	T.CD4_Tcm.stress	1.76e-03	Nonsignificant	0.88	1.05	Other	5	11
596	NK.adaptive_immature_precursor	1.75e-03	Nonsignificant	1.00	0.84	Other	358	111
597	T.CD4_Tcm.baseline	1.74e-03	Nonsignificant	0.91	0.92	Other	61	31
598	EPI.tracheal_basal.activated_stress	1.68e-03	Nonsignificant	0.04	1.44	Other	32	0
599	GRNLSA.proliferative_migratory	1.61e-03	Nonsignificant	0.88	0.85	Other	248	292
600	DC.cDC1.homeostatic_inhibitory	1.58e-03	Nonsignificant	—	0.00	Other	0	0
601	EPI.salivary_myoepithelial.baseline	1.35e-03	Nonsignificant	1.00	0.73	Other	42	141
602	NK.adaptive_axis_baseline	1.33e-03	Nonsignificant	1.00	0.85	Other	1,008	153
603	EPI.cervical_suprabasal.inflammatory_repair	1.23e-03	Nonsignificant	—	0.00	Other	0	0
604	T.CD8_Tem.signaling_turnover	1.22e-03	Nonsignificant	0.93	0.99	Other	425	683
605	T.CD4_Tcm.regulatory_poised	1.15e-03	Nonsignificant	0.91	0.92	Other	2	3
606	GRNLSA.secretory_remodeling	1.15e-03	Nonsignificant	0.89	0.69	Other	90	25
607	FIB.transitioning.ISG_primed_interface	1.13e-03	Nonsignificant	—	0.00	Other	17	80
608	NEU.INH_LAMP5.exc_inh_balance	1.13e-03	Nonsignificant	—	0.09	Other	46	2
609	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.13e-03	Nonsignificant	—	0.00	Other	0	0
610	MONO.CD16.baseline	1.09e-03	Nonsignificant	1.00	0.89	Other	50	1
611	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.04e-03	Nonsignificant	0.97	0.69	Other	33	34
612	T.CD4_Treg.central_naive_like	1.01e-03	Nonsignificant	1.00	0.10	Other	333	45
613	EPI.tracheal_suprabasal.transitional_wound	1.01e-03	Nonsignificant	—	0.25	Other	16	1
614	MEL.mature_oxidative_traffic	1.01e-03	Nonsignificant	0.99	0.36	Other	247	285
615	SCHWN.reactive_inflammatory	9.90e-04	Nonsignificant	—	0.33	Other	0	0
616	GRNLSA.stress_metabolic	9.80e-04	Nonsignificant	—	0.00	Other	1	2
617	T.CD4_Tcm.synapse_dynamics	9.50e-04	Nonsignificant	0.91	0.89	Other	15	10
618	T.CD4_Trm.metal_stress	9.18e-04	Nonsignificant	0.92	0.73	Other	34	58
619	IPSC.midbrain_primed	9.16e-04	Nonsignificant	1.00	0.78	Other	0	0
620	EPI.cervical_suprabasal.secretory_vesicle	8.85e-04	Nonsignificant	—	0.00	Other	0	0
621	NEU.INH_VIP.matrix	8.44e-04	Nonsignificant	—	0.00	Other	24	77
622	NK.adaptive_terminal_cytotoxic	8.40e-04	Nonsignificant	1.00	0.83	Other	485	802
623	ASTRO.stress_acute	8.33e-04	Nonsignificant	0.98	0.85	Other	60	56
624	T.CD8_Tem.stress_adapted	8.12e-04	Nonsignificant	0.93	0.88	Other	607	520
625	T.gamma_delta.central_memory	7.58e-04	Nonsignificant	0.74	0.96	Other	460	919
626	SCHWN.axon_contact_cardiac	7.40e-04	Nonsignificant	0.85	0.67	Other	18	63
627	EPI.skin_sweat_duct_keratinocyte.repair	7.08e-04	Nonsignificant	—	0.60	Other	0	0
628	FIB.neurolectin_mucosa.axon_responsive	6.99e-04	Nonsignificant	0.97	0.83	Other	10	10
629	ASTRO.A1_reactive	6.41e-04	Nonsignificant	0.98	0.89	Other	433	394
630	MONO.CD16.inflammatory	6.29e-04	Nonsignificant	1.00	0.84	Other	1,640	168
631	T.CD8_Tcm.helper_like	6.24e-04	Nonsignificant	1.00	0.54	Other	81	159
632	EPI.tracheal_suprabasal.secretory_immune	6.19e-04	Nonsignificant	—	0.00	Other	0	0
633	FIB.skin_sheath.ECM_immune	6.10e-04	Nonsignificant	—	0.00	Other	0	0
634	NK.cytokine_axis_baseline	6.06e-04	Nonsignificant	1.00	0.87	Other	1,172	116
635	EPI.skin_sweat_duct_keratinocyte.signal_gate	5.98e-04	Nonsignificant	—	0.00	Other	43	26
636	EPI.thymic_cortical.secretory_remodeling	5.63e-04	Nonsignificant	—	0.58	Other	4	1
637	EPI.colonocyte.goblet_interface	5.51e-04	Nonsignificant	—	0.00	Other	11	21
638	NK.cytokine_quiescent	5.36e-04	Nonsignificant	1.00	0.88	Other	623	1,062
639	T.CD8_Tem.TEMRA	5.27e-04	Nonsignificant	0.93	0.84	Other	920	1,088
640	T.CD8_Tem.motility_primed	5.23e-04	Nonsignificant	0.93	0.98	Other	269	4
641	T.CD4_cytotoxic.NK_adapted	5.00e-04	Nonsignificant	0.42	1.21	Other	82	33
642	FIB.barrier_purinergic.stress_GF_binding	4.92e-04	Nonsignificant	—	0.00	Other	0	0
643	EPI.tracheal_basal.homeostatic_progenitor	4.88e-04	Nonsignificant	0.99	0.40	Other	285	74
644	NK.adaptive_adipose_stress	4.86e-04	Nonsignificant	1.00	0.86	Other	374	39
645	NK.cytokine_biosynthetic_primed	4.56e-04	Nonsignificant	1.00	0.93	Other	360	21
646	NEU.INH_LAMP5.projecting	4.51e-04	Nonsignificant	—	0.00	Other	0	0
647	CHOND.pro_inflammatory	4.36e-04	Nonsignificant	1.00	0.31	Other	181	351
648	EPI.skin_sweat_duct_keratinocyte.barrier	4.19e-04	Nonsignificant	—	0.10	Other	0	0
649	EPI.lung_club_secretory.inflammatory	4.08e-04	Nonsignificant	—	0.00	Other	0	0
650	NEU.INH_VIP.develop_niche	3.93e-04	Nonsignificant	—	0.00	Other	0	0
651	NEU.INH_LAMP5.glial_interface	3.77e-04	Nonsignificant	—	0.00	Other	0	0
652	T.CD4_Tcm.secretory	3.73e-04	Nonsignificant	1.00	0.71	Other	20	11
653	EPI.salivary_myoepithelial.activated	3.70e-04	Nonsignificant	1.00	0.13	Other	85	281
654	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	3.59e-04	Nonsignificant	—	0.09	Other	0	0
655	EPI.lung_club_secretory.ciliogenesis_axoneme	3.51e-04	Nonsignificant	—	0.00	Other	0	0
656	IPSC.mesenchymal_primed	3.47e-04	Nonsignificant	1.00	0.76	Other	0	0
657	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	3.09e-04	Nonsignificant	0.97	0.41	Other	7	16
658	T.CD4_Tcm.RNA_control	3.00e-04	Nonsignificant	1.00	0.51	Other	96	4
659	NK.cytokine_vascular_patrolling	2.66e-04	Nonsignificant	1.00	0.87	Other	863	94
660	T.MAIT.stress	2.65e-04	Nonsignificant	—	0.00	Other	0	0
661	EPI.ileal_goblet.baseline	2.57e-04	Nonsignificant	0.87	0.96	Other	16	2
662	MONO.CD16.patrolling	2.56e-04	Nonsignificant	1.00	0.64	Other	797	216
663	EPI.colonocyte.junction_remodeling	2.56e-04	Nonsignificant	1.00	0.19	Other	218	305
664	FIB.neurolectin_mucosa.inflammatory	2.27e-04	Nonsignificant	0.97	0.30	Other	52	110
665	NEU.INH_VIP.excitatory_coupled	1.84e-04	Nonsignificant	—	0.00	Other	13	0
666	T.CD4_cytotoxic.precursor	1.68e-04	Nonsignificant	0.45	1.20	Other	156	67
667	ADIPO.inflammatory	1.62e-04	Nonsignificant	—	0.00	Other	0	0
668	FIB.skin_papillary.baseline	1.61e-04	Nonsignificant	—	0.00	Other	0	0
669	T.CD8_Tcm.gut_homing	1.56e-04	Nonsignificant	1.00	0.33	Other	380	112
670	NK.adaptive_biosynthetic_primed	1.55e-04	Nonsignificant	1.00	0.81	Other	244	405
671	NEU.INH_VIP.opioid	1.43e-04	Nonsignificant	—	0.00	Other	50	9
672	T.CD4_Tcm.retro_ZNF117	1.43e-04	Nonsignificant	1.00	0.50	Other	5	9
673	T.CD4_cytotoxic.terminal_effector	1.28e-04	Nonsignificant	0.64	1.05	Other	286	21
674	EPI.ileal_goblet.inflammatory_mucin	9.84e-05	Nonsignificant	0.87	0.35	Other	6	9
675	T.CD4_cytotoxic.activated	9.00e-05	Nonsignificant	0.67	0.98	Other	3	1
676	EPI.pancreatic_ductal_bicarbonate.stress	8.52e-05	Nonsignificant	—	0.00	Other	12	33
677	EPI.ileal_goblet.stress_metallothionein	6.82e-05	Nonsignificant	—	0.00	Other	4	11
678	ASTRO.immature_lipid	6.09e-05	Nonsignificant	0.98	0.73	Other	23	113
679	T.CD4_cytotoxic.baseline	5.53e-05	Nonsignificant	0.67	0.94	Other	0	0
680	DC.pDC.immature_metabolic	3.96e-05	Nonsignificant	0.60	1.09	Other	78	124
681	DC.pDC.poised_migratory	2.90e-05	Nonsignificant	0.60	1.10	Other	54	95
682	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.03e-05	Nonsignificant	—	0.00	Other	0	0
683	ASTRO.A2_reactive	6.02e-06	Nonsignificant	0.98	0.58	Other	10	37
684	DC.pDC.baseline	3.89e-06	Nonsignificant	0.94	0.67	Other	88	123
685	EPI.thymic_cortical.Notch_interface	3.46e-06	Nonsignificant	—	0.42	Other	82	137
686	IPSC.stromal_primed	2.18e-06	Nonsignificant	1.00	0.39	Other	0	0
687	EPI.thymic_cortical.baseline	1.44e-06	Nonsignificant	0.97	0.18	Other	185	386
688	EPI.skin_sweat_duct_keratinocyte.proliferative_S	8.76e-07	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

18 unique genes. Showing 1–18. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
FUT1	02-Medium	0.68	7.14	G1	C2	—	EC.liver_sinusoidal (Tier: relevant)	28 cells — complete matches	131	146
FGF21	02-Medium	0.64	6.43	G1	C2	—	—	—	232	667
MAMSTR	02-Medium	0.64	6.85	G1	C2	—	FIB.adventitial.baseline (Tier: relevant)	20 cells — complete matches	144	185
RASIP1	02-Medium	0.63	6.51	G1	C2	—	EC.heart_remodeling (Tier: specific) EC.liver_sinusoidal (Tier: relevant) EC.heart_remodeling.angiocrine (Tier: relevant) EC.heart_remodeling.capillary_metabolic (Tier: relevant) EC.heart_remodeling.remodeling_secretory (Tier: relevant) EC.liver_sinusoidal.prostanoid (Tier: relevant)	44 cells — complete matches	207	259
TNFAIP8	02-Medium	0.61	6.40	G1	C2	CHOND.pro_inflammatory (L2)	HEP.canalicular_transport.ductular_like_transition (Tier: specific) HEP.canalicular_transport.injury_stress (Tier: specific)	23 cells — complete matches	21	107
HSD17B4	02-Medium	0.59	5.33	G2	C1	—	—	EC.venous.remodeling_stalk (L2), EPI.extrahepatic_cholangiocyte.mucin_secretory (L2), EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2)	4	4
FUT2	02-Medium	0.58	7.03	G1	C2	—	—	36 cells — complete matches	113	124
IZUMO1	02-Medium	0.54	6.36	G2	C2	—	—	21 cells — complete matches	97	104
ENSG00000306119	02-Medium	0.48	6.79	G2	C2	—	—	—	93	102
FAM170A	02-Medium	0.45	3.24	G2	C1	—	—	—	3	4
SEC1P.2	02-Medium	0.42	6.73	G2	C2	—	—	—	105	110
NTN5	02-Medium	0.39	6.22	G2	C2	—	—	PC.IgG_systemic.interacting (L2)	86	95
CA11	02-Medium	0.37	6.37	G2	C2	—	EC.heart_remodeling.remodeling_secretory (Tier: relevant)	16 cells — complete matches	73	76
FAM83E	02-Medium	0.36	2.14	G2	C2	—	—	23 cells — complete matches	4	4
ENSG00000229855	02-Medium	0.34	1.12	G2	C1	—	—	—	0	0
RPL18	02-Medium	0.33	2.14	G2	C2	EC.heart_remodeling.translation_boost (L2), EPI.ileal_enterocyte_absorptive.villus_tip (L2), EPI.salivary_serous_acinar.secretory_active (L2)	—	56 cells — complete matches	3	4
SPHK2	02-Medium	0.33	2.20	G2	C2	—	EC.heart_remodeling (Tier: specific) EC.heart_remodeling.angiocrine (Tier: relevant)	8 cells — complete matches	0	0
ENSG00000248927	02-Medium	0.32	0.96	G2	C1	—	—	—	3	2

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.