Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000021 · All tissues

Acute bronchitis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Bronchitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	hepatocyte	11.39	Significant	6.88e-33	1.27	Specific	1,515	3,822
2	neuron	9.63	Significant	1.19e-06	1.18	Specific	330	1,328
3	natural_killer_cell	9.20	Significant	6.30e-32	1.24	Specific	1,204	2,052
4	T_cell	6.06	Significant	3.30e-49	1.23	Other	470	959
5	oligodendrocyte_precursor_cell	4.67	Nominal	0.68	1.08	Other	461	1,454
6	innate_lymphoid_cell_2	3.93	Nominal	1.00	0.95	Other	3	8
7	dendritic_cell	1.67	Nonsignificant	1.00	0.84	Other	496	724
8	epithelial_cell	1.66	Nonsignificant	1.00	0.85	Other	24	47
9	haematopoietic_progenitor_cell	1.34	Nonsignificant	1.00	0.78	Other	262	502
10	plasma_cell	1.00	Nonsignificant	1.00	0.81	Other	17	24
11	mesothelial_cell	0.91	Nonsignificant	1.00	0.69	Other	6	36
12	smooth_muscle_cell	0.80	Nonsignificant	1.00	0.79	Other	27	139
13	monocyte	0.60	Nonsignificant	1.00	0.74	Other	2,176	3,871
14	schwann_cell	0.51	Nonsignificant	1.00	0.72	Other	10	57
15	thymocyte	0.40	Nonsignificant	1.00	0.75	Other	168	512
16	granulocyte	0.38	Nonsignificant	1.00	0.67	Other	5	6
17	astrocyte	0.32	Nonsignificant	1.00	0.70	Other	256	1,203
18	platelet	0.28	Nonsignificant	—	0.00	Other	85	104
19	adipocyte	0.21	Nonsignificant	1.00	0.67	Other	33	111
20	B_cell	0.15	Nonsignificant	1.00	0.61	Other	356	694
21	macrophage	0.12	Nonsignificant	1.00	0.65	Other	813	1,732
22	fibroblast	0.11	Nonsignificant	1.00	0.64	Other	184	826
23	muscle_stem_cell	0.10	Nonsignificant	1.00	0.61	Other	7	27
24	endothelial_cell	0.07	Nonsignificant	1.00	0.58	Other	373	974
25	pericyte	0.05	Nonsignificant	1.00	0.55	Other	128	517
26	melanocyte	0.04	Nonsignificant	1.00	0.51	Other	97	309
27	induced_pluripotent_stem_cell	0.04	Nonsignificant	1.00	0.62	Other	0	0
28	granulosa_cell	0.04	Nonsignificant	1.00	0.63	Other	293	670
29	cardiomyocyte	0.04	Nonsignificant	1.00	0.64	Other	533	2,045
30	microglia	0.03	Nonsignificant	1.00	0.49	Other	61	129
31	adipose_stem_and_progenitor_cell	0.01	Nonsignificant	1.00	0.66	Other	327	954
32	chondrocyte	2.69e-03	Nonsignificant	1.00	0.39	Other	548	1,069
33	oligodendrocyte	2.42e-03	Nonsignificant	1.00	0.75	Other	385	1,507
34	skeletal_muscle_cell	3.15e-04	Nonsignificant	1.00	0.27	Other	944	2,600

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.alveolar_type_2	19.20	Significant	3.62e-09	1.30	Specific	813	1,853
2	NEU.EXC_NTNG1	15.51	Significant	—	1.24	—	0	0
3	NEU.EXC_CT	14.06	Significant	9.03e-06	2.54	—	362	384
4	T.CD4_cytotoxic	13.76	Significant	1.41e-08	1.81	Specific	855	1,493
5	NEU.INH_VIP	13.32	Significant	1.62e-04	2.17	—	241	366
6	HEP.canalicular_transport	13.01	Significant	1.53e-15	2.48	Specific	1,290	3,434
7	T.CD8_transitional	11.95	Significant	7.77e-35	1.95	Specific	497	932
8	HEP.periportal_metabolic	11.68	Significant	0.71	1.02	Specific	1,750	4,427
9	T.gamma_delta	11.67	Significant	4.47e-08	1.67	Specific	588	1,078
10	EPI.lung_club_secretory	11.09	Significant	0.84	1.22	Other	5	14
11	T.CD4_Tem	10.38	Significant	4.81e-07	1.55	Specific	365	697
12	T.MAIT	10.01	Significant	1.48e-07	1.60	Specific	469	855
13	T.CD8_Tcm	9.36	Significant	6.25e-03	1.35	Specific	460	926
14	NK.natural_killer_cell	9.20	Significant	—	—	Specific	1,204	2,045
15	T.CD4_Trm	9.16	Significant	3.35e-05	1.41	Specific	176	363
16	HEP.acute_phase	8.86	Significant	0.96	0.61	Specific	1,441	3,641
17	T.CD4_Th17	8.83	Significant	0.07	1.28	Relevant	421	794
18	NEU.EXC_IT	8.70	Significant	1.00	0.88	—	411	192
19	T.CD8_Tem	8.13	Significant	3.94e-10	1.52	Specific	1,083	1,857
20	NEU.INH_PVALB	6.85	Significant	1.00	0.14	—	193	183
21	T.CD8_Trm	6.54	Significant	0.34	1.08	Relevant	211	346
22	T.CD4_Tcm	5.44	Nominal	1.00	0.92	Other	494	988
23	EPI.skin_interfollicular_spinous	4.91	Nominal	0.84	1.13	Other	260	563
24	NEU.INH_LAMP5	4.81	Nominal	1.00	0.08	Other	263	532
25	OPC.oligodendrocyte_precursor_cell	4.67	Nominal	—	—	Other	413	1,269
26	T.CD4_Tfh	4.58	Nominal	1.00	0.69	Other	47	45
27	EPI.tracheal_suprabasal	4.31	Nominal	1.00	1.13	Other	29	56
28	T.CD4_transitional	4.05	Nominal	1.00	0.60	Other	48	110
29	EPI.tracheal_basal	3.99	Nominal	0.84	1.15	Other	398	1,120
30	ILC2.innate_lymphoid_cell_2	3.93	Nominal	—	—	Other	2	0
31	DC.pDC	2.61	Nonsignificant	0.02	1.49	Other	496	1,028
32	T.CD4_naive	2.50	Nonsignificant	1.00	0.16	Other	399	866
33	EPI.pancreatic_islet	2.29	Nonsignificant	1.00	0.98	Other	52	132
34	NEU.EXC_SYT2	2.11	Nonsignificant	—	0.00	Other	40	77
35	EPI.ileal_bile_transport	2.03	Nonsignificant	1.00	1.08	Other	61	93
36	EPI.colonic_enteroendocrine	2.03	Nonsignificant	—	0.87	Other	1	1
37	EPI.ileal_enterocyte_crypt	1.96	Nonsignificant	1.00	1.03	Other	67	113
38	T.CD4_Th2	1.93	Nonsignificant	—	0.00	Other	1	2
39	MONO.CD16	1.93	Nonsignificant	1.36e-15	1.34	Other	1,304	1,835
40	T.CD8_naive	1.75	Nonsignificant	1.00	0.03	Other	317	708
41	EPI.ileal_goblet	1.64	Nonsignificant	1.00	1.06	Other	181	432
42	DC.cDC1	1.58	Nonsignificant	0.86	0.74	Other	55	112
43	DC.cDC2	1.51	Nonsignificant	0.86	0.93	Other	1,189	1,793
44	T.CD4_Treg	1.51	Nonsignificant	1.00	0.01	Other	244	511
45	HPC.haematopoietic_progenitor_cell	1.34	Nonsignificant	—	—	Other	211	370
46	EPI.extrahepatic_cholangiocyte	1.25	Nonsignificant	—	0.82	Other	37	71
47	B.age_associated	1.23	Nonsignificant	6.81e-03	1.37	Other	207	350
48	HEP.pericentral_lipoprotein	1.19	Nonsignificant	—	0.00	Other	0	0
49	EPI.ileal_enterocyte_absorptive	1.10	Nonsignificant	1.00	0.90	Other	118	338
50	PC.IgG_systemic	1.07	Nonsignificant	0.23	1.28	Other	41	60
51	PC.IgA_muocsal	0.99	Nonsignificant	0.72	0.86	Other	18	31
52	EPI.tracheal_submucosal_gland	0.97	Nonsignificant	—	0.75	Other	0	0
53	FIB.hepatic_stellate_cell	0.94	Nonsignificant	—	2.07	Other	64	252
54	MESO.mesothelial_cell	0.91	Nonsignificant	—	—	Other	2	18
55	MAC.kupffer	0.89	Nonsignificant	0.53	1.12	Other	189	530
56	EC.liver_sinusoidal	0.80	Nonsignificant	0.01	1.28	Other	1,083	1,925
57	SMC.smooth_muscle_cell	0.80	Nonsignificant	—	—	Other	20	101
58	EPI.skin_keratinocyte_proliferating	0.78	Nonsignificant	1.00	1.02	Other	47	76
59	DC.mig	0.70	Nonsignificant	—	0.00	Other	89	156
60	EPI.salivary_serous_acinar	0.70	Nonsignificant	1.00	0.87	Other	233	531
61	EPI.endocervical_secretory	0.61	Nonsignificant	—	0.56	Other	0	0
62	EPI.esophageal_suprabasal	0.59	Nonsignificant	1.00	0.88	Other	158	404
63	GRANU.MAST	0.58	Nonsignificant	9.43e-04	1.70	Other	5	6
64	EPI.gastric_foveolar	0.58	Nonsignificant	—	0.57	Other	0	0
65	EPI.renal_distal_tubule	0.53	Nonsignificant	1.00	0.92	Other	133	361
66	EPI.colonic_tuft	0.51	Nonsignificant	—	0.50	Other	7	24
67	SCHWN.schwann_cell	0.51	Nonsignificant	—	—	Other	7	33
68	EPI.pancreatic_ductal_mucinous	0.48	Nonsignificant	1.00	0.85	Other	219	430
69	EPI.hepatic_ductular_cholangiocyte	0.47	Nonsignificant	1.00	0.79	Other	83	243
70	THYMO.thymocyte	0.40	Nonsignificant	—	—	Other	163	495
71	EPI.esophageal_basal	0.38	Nonsignificant	1.00	0.80	Other	4	10
72	MONO.CD14	0.34	Nonsignificant	1.00	0.08	Other	2,294	4,139
73	MAC.resident_cardiac	0.34	Nonsignificant	0.53	1.08	Other	485	1,074
74	EPI.bile_duct_cholangiocyte	0.32	Nonsignificant	1.00	0.96	Other	37	60
75	ASTRO.astrocyte	0.32	Nonsignificant	—	—	Other	228	1,111
76	FIB.suburothelial	0.30	Nonsignificant	0.41	1.14	Other	122	432
77	MAC.microglia_like	0.29	Nonsignificant	1.00	1.09	Other	124	179
78	PLAT.platelet	0.28	Nonsignificant	—	0.00	Other	38	53
79	EPI.skin_keratinocyte_progenitor	0.27	Nonsignificant	—	0.37	Other	0	3
80	EPI.skin_hair_follicle_bulge	0.26	Nonsignificant	1.00	0.74	Other	51	178
81	ADIPO.adipocyte	0.21	Nonsignificant	—	—	Other	20	62
82	EPI.ectocervical_granular	0.21	Nonsignificant	—	0.05	Other	11	23
83	EPI.colonocyte	0.21	Nonsignificant	1.00	0.76	Other	294	815
84	EPI.skin_keratinocyte_basal	0.18	Nonsignificant	—	0.19	Other	13	26
85	FIB.adventitial	0.17	Nonsignificant	0.41	1.04	Other	268	1,447
86	FIB.perivascular_interface	0.17	Nonsignificant	0.78	1.12	Other	0	0
87	FIB.skin_sheath	0.16	Nonsignificant	0.97	1.07	Other	49	118
88	MAC.MDM	0.16	Nonsignificant	1.00	1.00	Other	623	986
89	B.naive	0.13	Nonsignificant	0.64	1.02	Other	307	595
90	B.memory	0.11	Nonsignificant	1.00	0.90	Other	442	882
91	EPI.cervical_suprabasal	0.11	Nonsignificant	—	0.18	Other	14	50
92	EPI.skin_follicular_keratinizing	0.11	Nonsignificant	1.00	0.70	Other	30	81
93	EPI.skin_appendage_keratinocyte	0.11	Nonsignificant	1.00	0.97	Other	87	222
94	FIB.transitioning	0.11	Nonsignificant	1.00	0.98	Other	172	497
95	FIB.tracheal_subepithelial	0.10	Nonsignificant	—	0.95	Other	0	0
96	MUSC.muscle_stem_cell	0.10	Nonsignificant	—	—	Other	4	18
97	EC.heart_remodeling	0.09	Nonsignificant	0.60	1.04	Other	569	1,594
98	EPI.skin_hair_follicle_companion	0.09	Nonsignificant	—	0.05	Other	8	12
99	EPI.pancreatic_ductal_bicarbonate	0.09	Nonsignificant	1.00	0.65	Other	131	548
100	FIB.lung_alveolar	0.08	Nonsignificant	—	0.95	Other	6	15
101	EPI.salivary_duct_excretory	0.08	Nonsignificant	1.00	0.67	Other	85	180
102	EC.arterial	0.06	Nonsignificant	1.00	0.99	Other	356	885
103	MAC.resident_iron	0.05	Nonsignificant	1.00	0.95	Other	16	21
104	PERI.pericyte	0.05	Nonsignificant	—	—	Other	117	0
105	FIB.skin_neurosecretory	0.05	Nonsignificant	—	0.89	Other	0	0
106	EPI.salivary_intercalated_defense	0.05	Nonsignificant	1.00	0.57	Other	81	161
107	EPI.intrahepatic_cholangiocyte_defense	0.04	Nonsignificant	—	0.03	Other	8	13
108	EPI.thymic_medullary	0.04	Nonsignificant	1.00	0.65	Other	26	133
109	FIB.reticular	0.04	Nonsignificant	1.00	0.86	Other	19	87
110	MEL.melanocyte	0.04	Nonsignificant	—	—	Other	79	242
111	GRANU.neutrophil	0.04	Nonsignificant	1.00	0.00	Other	1,235	2,649
112	FIB.barrier_purinergic	0.04	Nonsignificant	—	0.47	Other	1	3
113	IPSC.induced_pluripotent_stem_cell	0.04	Nonsignificant	—	—	Other	0	0
114	GRNLSA.granulosa_cell	0.04	Nonsignificant	—	—	Other	257	0
115	CM.cardiomyocyte	0.04	Nonsignificant	—	—	Other	524	2,032
116	EC.capillary	0.03	Nonsignificant	1.00	0.90	Other	514	1,635
117	MG.microglia	0.03	Nonsignificant	—	—	Other	49	0
118	EPI.skin_sebaceous_duct_luminal	0.02	Nonsignificant	1.00	0.54	Other	100	249
119	EPI.renal_immature_ureteric_bud	0.02	Nonsignificant	1.00	0.54	Other	217	569
120	EPI.pancreatic_acinar	0.02	Nonsignificant	1.00	0.56	Other	429	1,475
121	FIB.skin_tenogenic	0.01	Nonsignificant	—	0.64	Other	108	227
122	EC.venous	0.01	Nonsignificant	1.00	0.77	Other	516	1,387
123	ASPC.adipose_stem_and_progenitor_cell	0.01	Nonsignificant	—	—	Other	324	930
124	FIB.skin_papillary	0.01	Nonsignificant	—	0.60	Other	0	0
125	EPI.renal_principal_cell	9.93e-03	Nonsignificant	1.00	0.47	Other	207	403
126	EPI.intrahepatic_cholangiocyte_transport	9.71e-03	Nonsignificant	—	0.00	Other	12	42
127	EPI.renal_proximal_tubule	8.34e-03	Nonsignificant	1.00	0.50	Other	525	806
128	FIB.interstitial	6.50e-03	Nonsignificant	1.00	0.65	Other	288	940
129	MAC.LAM	6.39e-03	Nonsignificant	1.00	0.75	Other	914	2,064
130	EPI.salivary_duct_ion_transport	5.48e-03	Nonsignificant	1.00	0.51	Other	5	11
131	FIB.neurolectin_mucosa	4.21e-03	Nonsignificant	1.00	0.65	Other	133	394
132	MAC.resident_repair	2.82e-03	Nonsignificant	1.00	0.84	Other	796	1,426
133	CHOND.chondrocyte	2.69e-03	Nonsignificant	—	—	Other	519	730
134	OLG.oligodendrocyte	2.42e-03	Nonsignificant	—	—	Other	384	1,397
135	EC.lymphatic	1.62e-03	Nonsignificant	1.00	0.54	Other	630	998
136	EPI.alveolar_type_1	1.49e-03	Nonsignificant	1.00	0.34	Other	26	101
137	EPI.pancreatic_ductal_perivascular	1.48e-03	Nonsignificant	1.00	0.41	Other	4	30
138	EPI.salivary_mucous_acinar	1.05e-03	Nonsignificant	1.00	0.64	Other	639	1,189
139	FIB.barrier_secretory	9.06e-04	Nonsignificant	1.00	0.55	Other	81	228
140	EPI.renal_thick_ascending_limb	8.92e-04	Nonsignificant	1.00	0.31	Other	453	1,153
141	EPI.renal_intercalated_cell_type_B	7.70e-04	Nonsignificant	—	0.00	Other	6	7
142	EPI.skin_sweat_duct_keratinocyte	7.61e-04	Nonsignificant	1.00	0.32	Other	146	301
143	EPI.pancreatic_ductal_progenitor	7.61e-04	Nonsignificant	1.00	0.38	Other	234	873
144	EPI.salivary_myoepithelial	7.06e-04	Nonsignificant	1.00	0.32	Other	191	714
145	MAC.proliferating	5.07e-04	Nonsignificant	1.00	0.86	Other	87	253
146	SKM.type_1_slow	3.23e-04	Nonsignificant	0.61	0.99	Other	923	2,478
147	SKM.type_2_fast	3.09e-04	Nonsignificant	0.61	1.01	Other	972	2,639
148	EPI.renal_intercalated_cell_type_A	1.66e-04	Nonsignificant	1.00	0.26	Other	67	142
149	EPI.lung_multiciliated	7.80e-05	Nonsignificant	1.00	0.19	Other	16	49
150	EPI.thymic_cortical	4.27e-05	Nonsignificant	1.00	0.33	Other	442	824
151	B.germinal_center	2.45e-05	Nonsignificant	1.00	0.00	Other	233	655
152	MAC.alveolar	2.04e-05	Nonsignificant	1.00	0.43	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.alveolar_type_2.injury_primed	31.93	Significant	4.13e-06	2.33	—	434	245
2	EPI.lung_club_secretory.inflammatory	24.27	Significant	—	1.47	Relevant	0	0
3	NEU.INH_VIP.cannabinoid	22.37	Significant	—	1.15	—	0	0
4	NEU.INH_VIP.matrix	21.07	Significant	—	1.28	—	24	77
5	NEU.INH_VIP.develop_niche	20.44	Significant	—	1.23	—	0	0
6	HEP.periportal_metabolic.urea_onecarbon_secretory	19.88	Significant	4.41e-14	2.87	Specific	1,332	3,053
7	NEU.EXC_NTNG1.nuclear_reg	16.75	Significant	—	0.67	—	0	0
8	T.CD4_cytotoxic.precursor	16.64	Significant	0.33	1.50	—	156	67
9	NEU.EXC_CT.Ca2_signaling	16.48	Significant	—	0.84	—	68	17
10	NEU.INH_VIP.opioid	15.92	Significant	—	0.54	—	50	9
11	HEP.canalicular_transport.ductular_like_transition	15.79	Significant	0.11	1.57	—	400	87
12	T.CD4_cytotoxic.NK_adapted	15.70	Significant	0.28	1.76	—	82	33
13	NEU.EXC_CT.Ca2_sensor	15.68	Significant	—	0.37	—	0	0
14	EPI.alveolar_type_2.baseline_surfactant	15.62	Significant	1.00	0.59	—	64	9
15	T.CD4_cytotoxic.activated	15.18	Significant	0.35	1.33	Relevant	3	1
16	T.CD8_transitional.early	15.03	Significant	1.04e-05	1.96	—	327	55
17	T.gamma_delta.central_memory	14.93	Significant	4.73e-04	2.21	Specific	460	919
18	HEP.canalicular_transport.baseline	14.72	Significant	0.39	1.33	Relevant	199	477
19	NEU.EXC_NTNG1.synaptic	14.10	Significant	—	0.00	—	0	0
20	HEP.canalicular_transport.injury_stress	13.99	Significant	0.01	1.87	—	289	24
21	HEP.canalicular_transport.secretory_ERAD_UPR	13.88	Significant	0.52	1.13	—	232	28
22	NEU.EXC_CT.projector	13.84	Significant	0.66	0.71	—	87	26
23	HEP.acute_phase.hypoxia_lipid	13.81	Significant	—	2.04	Relevant	0	0
24	T.CD8_Tcm.effector_bias	13.79	Significant	2.32e-04	2.18	Specific	199	329
25	T.CD4_Th17.cytotoxic	13.67	Significant	5.41e-04	2.13	—	332	123
26	T.CD8_Tcm.gut_homing	13.04	Significant	0.20	1.51	—	380	112
27	T.CD4_Tem.long_term_memory	12.91	Significant	0.01	1.81	Specific	314	587
28	T.MAIT.cytotoxic	12.87	Significant	0.10	1.87	—	52	15
29	HEP.canalicular_transport.pericentral_like_hypoxia	12.78	Significant	1.00	0.61	—	326	8
30	NEU.INH_VIP.excitatory_coupled	12.59	Significant	—	0.07	—	13	0
31	T.MAIT.stress	12.33	Significant	—	0.75	—	0	0
32	T.CD4_Trm.stress_adaptive	12.30	Significant	0.35	1.36	Relevant	8	22
33	HEP.periportal_metabolic.inflammatory_activated	12.27	Significant	0.10	1.63	Relevant	712	1,610
34	T.CD4_cytotoxic.baseline	12.26	Significant	0.98	0.31	—	0	0
35	NEU.INH_VIP.canonical_disinhibitory	12.13	Significant	0.70	0.74	—	59	38
36	EPI.lung_club_secretory.canonical_surfactant	12.10	Significant	—	0.14	Relevant	74	104
37	NEU.INH_VIP.nuclear_reg	12.07	Significant	—	0.00	—	20	4
38	NEU.EXC_CT.remodeling	11.76	Significant	—	0.00	—	23	1
39	NK.cytokine_axis_baseline	11.67	Significant	1.20e-18	2.88	—	1,172	116
40	T.CD4_cytotoxic.terminal_effector	11.65	Significant	0.98	0.20	—	286	21
41	T.CD4_Trm.cytotoxic_effector	11.51	Significant	0.35	1.37	Relevant	118	77
42	NEU.EXC_IT.transitional	11.44	Significant	4.70e-03	2.45	—	237	142
43	EPI.alveolar_type_2.stress_response	11.33	Significant	1.00	0.03	Relevant	675	1,562
44	NK.cytokine_biosynthetic_primed	11.27	Significant	0.17	1.58	—	360	21
45	T.gamma_delta.early_effector	11.26	Significant	0.66	1.03	—	89	0
46	HEP.canalicular_transport.inflammatory	11.23	Significant	1.00	0.13	—	1,335	194
47	T.CD4_Tcm.effector_like	10.94	Significant	7.15e-08	2.38	Specific	293	533
48	HEP.periportal_metabolic.acute_phase_barrier	10.85	Significant	0.94	1.03	—	533	138
49	T.CD8_transitional.Trm_primed	10.80	Significant	0.83	1.06	—	108	15
50	NK.cytokine_vascular_patrolling	10.79	Significant	0.08	1.66	—	863	94
51	T.CD4_Tem.cytotoxic_effector	10.77	Significant	0.78	1.07	Relevant	225	398
52	HEP.periportal_metabolic.stress_checkpoint	10.68	Significant	0.94	0.96	Relevant	234	786
53	T.CD8_transitional.effector_primed	10.57	Significant	0.99	0.77	—	435	151
54	NK.cytokine_tissue_resident	10.51	Significant	0.17	1.62	—	74	82
55	T.MAIT.MAPK_brake	10.42	Significant	0.85	0.78	Relevant	44	66
56	T.MAIT.early_activation	10.24	Significant	0.36	1.46	—	57	4
57	T.MAIT.vesicle	10.11	Significant	0.85	0.81	Relevant	37	65
58	NEU.INH_VIP.serotonergic	10.09	Significant	—	0.00	—	9	2
59	T.CD4_Tem.inflammatory	10.02	Significant	1.00	0.69	—	28	6
60	HEP.acute_phase.complement_metabolic	9.87	Significant	0.03	2.06	Specific	1,423	3,464
61	T.CD8_transitional.APC_like	9.83	Significant	0.99	0.51	—	205	62
62	T.MAIT.quiescent	9.82	Significant	0.85	0.93	—	100	5
63	NK.cytokine_repair_primed	9.65	Significant	0.48	1.33	—	266	11
64	NEU.EXC_IT.adhesion	9.56	Significant	0.67	1.04	—	252	108
65	T.CD8_Tem.early_helper_like	9.42	Significant	0.11	1.68	Relevant	445	755
66	NK.cytokine_quiescent	9.29	Significant	0.82	1.11	Relevant	623	1,062
67	HEP.acute_phase.inflammatory	9.25	Significant	0.68	1.16	Relevant	382	649
68	NEU.EXC_IT.neuromodulated	9.19	Significant	0.43	1.47	—	176	116
69	T.CD4_Trm.central_like	9.15	Significant	1.00	0.94	Relevant	38	31
70	NK.cytokine_lung_immediate_early	9.14	Significant	0.17	1.60	—	424	274
71	T.CD4_Trm.baseline	9.09	Significant	0.35	1.27	Relevant	31	21
72	NEU.EXC_IT.callosal	8.92	Significant	0.67	1.07	—	286	119
73	HEP.periportal_metabolic.canonical_urea_cycle	8.80	Significant	1.00	0.53	—	1,464	269
74	T.gamma_delta.cytotoxic_effector	8.80	Significant	1.00	0.17	—	349	109
75	NEU.INH_VIP.regulatory_remodeling	8.80	Significant	—	0.00	—	6	1
76	T.CD8_Tem.stress_adapted	8.73	Significant	0.23	1.34	Relevant	607	520
77	NEU.INH_PVALB.neuromodulatory	8.61	Significant	—	0.72	—	0	0
78	NEU.INH_PVALB.serotonergic	8.57	Significant	—	1.04	—	0	0
79	HEP.canalicular_transport.sterol_lipid_biosynthesis	8.51	Significant	—	0.00	Relevant	10	20
80	T.CD8_Tem.motility_primed	8.50	Significant	0.58	1.11	—	269	4
81	T.CD8_Tcm.baseline	8.43	Significant	1.00	0.62	Relevant	90	89
82	HEP.acute_phase.baseline	8.40	Significant	1.00	0.19	—	946	19
83	NK.adaptive_HLAE_tuned	8.39	Significant	1.00	0.69	—	1,124	189
84	T.CD4_Th17.baseline	8.34	Significant	0.89	0.93	—	51	5
85	T.CD8_Tem.baseline	8.33	Significant	0.20	1.41	Relevant	458	356
86	HEP.acute_phase.stress_secretory	8.29	Significant	0.68	1.09	—	26	3
87	NEU.EXC_IT.structural	8.17	Significant	0.67	0.93	—	171	41
88	NK.adaptive_biosynthetic_primed	8.11	Significant	1.00	0.58	Relevant	244	405
89	EPI.lung_club_secretory.ciliogenesis_primed	8.11	Significant	—	0.37	Relevant	0	0
90	HEP.periportal_metabolic.apolipoprotein_secretory	7.97	Significant	1.00	0.66	Relevant	43	110
91	T.CD8_Trm.cytotoxic	7.87	Significant	0.03	1.65	Specific	165	85
92	NEU.INH_VIP.LAMP5_hybrid	7.79	Significant	—	0.00	—	1	9
93	T.CD8_transitional.stress	7.68	Significant	—	0.00	—	24	34
94	T.CD4_Tfh.precursor_migratory	7.59	Significant	0.13	1.46	Relevant	72	27
95	HEP.acute_phase.complement_antiviral	7.58	Significant	1.00	0.32	Relevant	377	751
96	NEU.INH_PVALB.metabotropic	7.56	Significant	—	0.26	—	0	0
97	T.CD8_Tem.signaling_turnover	7.48	Significant	1.00	0.63	Relevant	425	683
98	NK.cytokine_tissue_activation	7.45	Significant	1.00	0.43	Relevant	267	450
99	NK.adaptive_adipose_stress	7.45	Significant	1.00	0.43	—	374	39
100	NK.adaptive_terminal_cytotoxic	7.37	Significant	1.00	0.33	Relevant	485	802
101	T.CD4_Trm.activated	7.33	Significant	1.00	0.61	—	32	26
102	NK.adaptive_axis_baseline	7.26	Significant	1.00	0.34	—	1,008	153
103	NEU.INH_PVALB.fastspike	7.22	Significant	—	0.17	—	24	22
104	T.CD4_naive.activated_stress	7.20	Significant	5.15e-11	2.76	Specific	339	429
105	T.CD8_Trm.homeostatic	7.11	Significant	0.41	1.26	—	42	5
106	NK.adaptive_classII_inhibitory	6.99	Significant	1.00	0.28	—	880	154
107	NEU.INH_PVALB.nuclear_reg	6.93	Significant	1.00	0.70	—	25	12
108	HEP.periportal_metabolic.xenobiotic_detox	6.84	Significant	1.00	0.05	—	1,440	139
109	T.CD8_Tcm.helper_like	6.83	Significant	1.00	0.25	Relevant	81	159
110	T.MAIT.migratory	6.79	Significant	1.00	0.05	—	10	1
111	T.CD4_Tcm.crosstalk_myeloid	6.76	Significant	0.37	1.52	Relevant	5	4
112	NEU.EXC_IT.guidance	6.70	Significant	1.00	0.06	—	274	63
113	NK.adaptive_immature_precursor	6.59	Significant	1.00	0.23	—	358	111
114	T.CD4_Tcm.Th2_like	6.59	Significant	0.37	1.41	Relevant	23	55
115	T.CD4_Tem.transitional_CM	6.49	Significant	1.00	0.11	—	31	20
116	T.CD4_Tcm.regulatory_poised	6.33	Significant	0.37	1.40	Relevant	2	3
117	HEP.acute_phase.proliferative	6.21	Significant	—	0.00	Relevant	4	6
118	EPI.skin_interfollicular_spinous.early_differentiation	6.18	Significant	0.07	1.72	Relevant	89	19
119	T.CD4_Trm.metal_stress	6.11	Significant	1.00	0.37	Relevant	34	58
120	T.CD8_Tem.TEMRA	6.11	Significant	1.00	0.14	Relevant	920	1,088
121	EPI.skin_interfollicular_spinous.baseline	6.07	Significant	0.07	1.68	Relevant	35	3
122	T.CD8_Trm.inflammatory	5.93	Significant	0.98	0.67	Relevant	124	176
123	EPI.skin_interfollicular_spinous.stress_UPR	5.87	Significant	—	0.37	Relevant	0	0
124	T.CD4_Tcm.secretory	5.74	Significant	0.99	0.96	Other	20	11
125	NEU.INH_LAMP5.glial_interface	5.64	Significant	—	0.86	—	0	0
126	T.CD4_Tcm.synapse_dynamics	5.60	Significant	0.99	1.00	Other	15	10
127	T.CD4_Tcm.tissue_homing	5.42	Nominal	0.37	1.38	Other	78	46
128	T.CD4_Tcm.DC_interact	5.39	Nominal	0.99	0.91	Other	72	32
129	ILC2.activated	5.35	Nominal	—	0.00	Other	0	0
130	T.CD4_Tcm.retro_ZNF117	5.34	Nominal	0.99	1.08	Other	5	9
131	T.CD4_transitional.baseline	5.25	Nominal	0.05	1.63	Other	59	97
132	OPC.homeostatic	5.23	Nominal	0.03	1.99	Other	394	160
133	T.CD4_Tcm.RNA_control	5.16	Nominal	0.99	0.94	Other	96	4
134	NEU.INH_PVALB.chandelier	5.14	Nominal	1.00	0.00	Other	19	16
135	NEU.INH_LAMP5.exc_inh_balance	5.13	Nominal	—	0.37	Other	46	2
136	HEP.periportal_metabolic.stress_chaperone	5.09	Nominal	—	0.00	Other	66	128
137	ILC2.quiescent	4.98	Nominal	—	0.44	Other	0	0
138	EPI.skin_interfollicular_spinous.stress_oxidative	4.93	Nominal	—	0.00	Other	0	0
139	EPI.colonic_enteroendocrine.progenitor	4.78	Nominal	—	0.97	Other	0	0
140	T.CD4_Th17.migratory	4.74	Nominal	1.00	0.00	Other	13	23
141	T.CD4_Tcm.migratory_cilium	4.71	Nominal	1.00	0.62	Other	5	10
142	T.CD8_naive.mito_proteostasis	4.70	Nominal	2.04e-07	2.54	Other	428	100
143	T.CD4_Trm.helper_like	4.69	Nominal	1.00	0.08	Other	84	147
144	NK.immature_bridge	4.69	Nominal	1.00	0.07	Other	117	122
145	OPC.proliferative_immune_interact	4.68	Nominal	0.74	1.00	Other	180	373
146	T.CD8_Trm.dendritic_recruiter	4.49	Nominal	0.98	0.52	Other	47	85
147	EPI.tracheal_basal.homeostatic_progenitor	4.36	Nominal	0.17	1.73	Other	285	74
148	T.CD4_transitional.primed_cytotoxic	4.35	Nominal	1.00	1.01	Other	28	30
149	EPI.tracheal_suprabasal.transitional_wound	4.32	Nominal	—	0.00	Other	16	1
150	EPI.tracheal_suprabasal.secretory_immune	4.30	Nominal	—	0.00	Other	0	0
151	T.CD8_Trm.muscosal_Tc17	4.30	Nominal	0.98	0.42	Other	19	38
152	NEU.INH_LAMP5.projecting	4.28	Nominal	—	0.00	Other	0	0
153	EPI.pancreatic_islet.alpha	4.23	Nominal	—	0.80	Other	152	330
154	T.CD8_Tcm.NK_like	4.16	Nominal	1.00	0.04	Other	334	581
155	T.CD4_Tcm.Tfh_like	4.15	Nominal	1.00	0.47	Other	102	214
156	EPI.skin_interfollicular_spinous.proliferative	4.11	Nominal	—	0.00	Other	0	0
157	OPC.premyelinating	4.07	Nominal	1.00	0.12	Other	185	12
158	T.CD4_Tfh.effector_migratory	3.88	Nominal	0.97	0.96	Other	122	57
159	EPI.skin_interfollicular_spinous.upper_lipid	3.83	Nominal	—	0.00	Other	6	6
160	NEU.INH_LAMP5.rosehip	3.79	Nominal	—	0.00	Other	0	0
161	T.CD4_Tcm.baseline	3.70	Nominal	1.00	0.17	Other	61	31
162	T.CD4_Tcm.stress	3.70	Nominal	1.00	0.33	Other	5	11
163	DC.cDC1.homeostatic_inhibitory	3.55	Nominal	—	1.21	Other	0	0
164	NEU.INH_VIP.enkephalinergic	3.48	Nominal	—	0.00	Other	0	0
165	EPI.tracheal_basal.activated_stress	3.44	Nominal	1.00	0.00	Other	32	0
166	MAC.kupffer.monocyte_like	3.38	Nominal	—	0.00	Other	0	0
167	T.CD4_Tcm.imprinted_splicing	3.31	Nominal	1.00	0.11	Other	6	17
168	CM.inflammatory	3.21	Nominal	—	2.83	Other	0	0
169	T.CD4_Tcm.APC_mimicry	3.20	Nominal	1.00	0.13	Other	54	43
170	T.CD4_naive.purinergic	2.93	Nonsignificant	0.68	1.17	Other	49	1
171	EPI.ileal_enterocyte_crypt.secretory_precursor	2.89	Nonsignificant	—	1.01	Other	0	0
172	T.CD4_naive.survival_neddylation	2.86	Nonsignificant	0.72	1.08	Other	26	38
173	DC.pDC.poised_migratory	2.79	Nonsignificant	0.31	1.69	Other	54	95
174	MONO.CD16.inflammatory	2.79	Nonsignificant	9.20e-06	1.82	Other	1,640	168
175	T.CD4_naive.proteostasis_mitoprot	2.74	Nonsignificant	0.68	1.27	Other	15	37
176	EPI.skin_interfollicular_spinous.transition_basal	2.73	Nonsignificant	1.00	0.05	Other	100	127
177	T.CD4_transitional.APC_interacting	2.71	Nonsignificant	1.00	0.50	Other	10	14
178	T.CD4_naive.neddylation	2.65	Nonsignificant	0.56	1.29	Other	104	222
179	T.CD4_naive.Treg_like	2.63	Nonsignificant	0.92	0.92	Other	121	72
180	T.CD4_transitional.primed_helper_effector	2.60	Nonsignificant	1.00	0.31	Other	19	43
181	T.CD4_naive.resist_bystander	2.60	Nonsignificant	0.46	1.40	Other	40	25
182	DC.pDC.baseline	2.60	Nonsignificant	0.81	0.92	Other	88	123
183	EPI.ileal_enterocyte_crypt.villus_transition	2.57	Nonsignificant	—	0.83	Other	7	10
184	MONO.CD16.platelet_bound	2.56	Nonsignificant	0.25	1.35	Other	372	508
185	T.CD4_naive.neddylation_mitoprot	2.55	Nonsignificant	0.92	0.87	Other	93	56
186	T.CD4_Treg.central_naive_like	2.55	Nonsignificant	0.02	1.60	Other	333	45
187	T.CD4_naive.survival_mitoprot	2.54	Nonsignificant	0.68	1.15	Other	13	7
188	T.CD4_naive.proteostasis	2.53	Nonsignificant	0.92	0.72	Other	14	9
189	EC.liver_sinusoidal.inflammatory	2.52	Nonsignificant	—	1.23	Other	223	154
190	T.CD4_naive.survival	2.50	Nonsignificant	0.68	1.14	Other	12	17
191	T.CD4_naive.mature_mitoprot	2.46	Nonsignificant	0.92	0.84	Other	212	476
192	T.CD4_Th2.precursor	2.45	Nonsignificant	—	0.00	Other	0	0
193	DC.pDC.immature_metabolic	2.45	Nonsignificant	0.84	0.50	Other	78	124
194	EPI.ileal_goblet.immature	2.44	Nonsignificant	—	1.13	Other	0	0
195	T.CD4_naive.homeostatic	2.35	Nonsignificant	0.92	0.79	Other	215	108
196	NEU.EXC_SYT2.nuclear_reg	2.32	Nonsignificant	—	0.00	Other	0	0
197	T.CD4_naive.mature	2.30	Nonsignificant	0.92	0.85	Other	211	100
198	MONO.CD16.baseline	2.25	Nonsignificant	0.25	1.26	Other	50	1
199	EPI.ileal_enterocyte_crypt.baseline	2.22	Nonsignificant	0.95	1.00	Other	11	6
200	DC.cDC2.antiviral	2.22	Nonsignificant	0.43	1.20	Other	100	37
201	DC.cDC2.migratory	2.18	Nonsignificant	0.43	1.26	Other	185	39
202	T.CD4_Tfh.suppression_exhaustion	2.16	Nonsignificant	0.97	0.32	Other	0	2
203	ASPC.signal_integrator	2.13	Nonsignificant	—	2.22	Other	0	0
204	EPI.ileal_bile_transport.absorptive_xenobiotic	2.11	Nonsignificant	0.17	1.67	Other	11	12
205	HPC.GMP_granulocytic	2.11	Nonsignificant	—	0.35	Other	3	3
206	HPC.MPP_activated	2.02	Nonsignificant	—	0.79	Other	0	0
207	HPC.MPP_IEG	1.98	Nonsignificant	0.64	1.17	Other	45	46
208	NEU.EXC_SYT2.synaptic	1.98	Nonsignificant	—	0.00	Other	0	0
209	EPI.renal_distal_tubule.immune_modulatory	1.97	Nonsignificant	—	1.34	Other	0	0
210	MAC.resident_cardiac.antigen_presenting	1.90	Nonsignificant	0.43	1.24	Other	52	27
211	DC.cDC2.monocyte_like	1.90	Nonsignificant	0.49	1.14	Other	1,285	791
212	T.CD8_naive.nfkb_related	1.86	Nonsignificant	0.80	1.05	Other	1	0
213	DC.cDC2.adhesion_signaling	1.84	Nonsignificant	0.52	1.09	Other	35	9
214	T.CD8_naive.vesicle_secretory	1.82	Nonsignificant	0.76	1.16	Other	42	0
215	T.CD4_Tfh.canonical_GC_helper	1.82	Nonsignificant	0.97	0.41	Other	1	2
216	EPI.ileal_bile_transport.detox_transcytosis	1.80	Nonsignificant	—	0.00	Other	0	1
217	MONO.CD14.APC_like	1.78	Nonsignificant	6.28e-08	1.37	Other	1,686	2,493
218	EPI.endocervical_secretory.squamous_barrier	1.75	Nonsignificant	—	0.67	Other	0	0
219	T.CD8_naive.effector_transition	1.75	Nonsignificant	0.76	1.18	Other	35	62
220	MONO.CD16.hepatic_mac_like	1.75	Nonsignificant	0.43	1.09	Other	803	117
221	T.CD4_Treg.tissue_effector	1.73	Nonsignificant	0.59	1.11	Other	16	13
222	MESO.activated_migratory	1.69	Nonsignificant	—	1.04	Other	0	0
223	T.CD8_naive.lipid_synthesis	1.69	Nonsignificant	0.76	1.15	Other	6	4
224	DC.cDC1.baseline	1.68	Nonsignificant	—	0.49	Other	0	0
225	EPI.ileal_enterocyte_crypt.proliferative_G2M	1.64	Nonsignificant	—	0.00	Other	19	54
226	HPC.LMPP	1.64	Nonsignificant	0.64	1.06	Other	65	31
227	EPI.ileal_enterocyte_crypt.bile_transport	1.63	Nonsignificant	0.95	0.67	Other	2	0
228	T.CD8_naive.baseline	1.63	Nonsignificant	0.99	0.90	Other	142	2
229	EPI.extrahepatic_cholangiocyte.barrier_interface	1.62	Nonsignificant	—	0.00	Other	0	0
230	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.62	Nonsignificant	—	0.87	Other	135	290
231	PC.IgG_systemic.secretory	1.60	Nonsignificant	0.30	1.37	Other	0	0
232	EPI.ileal_goblet.baseline	1.60	Nonsignificant	0.93	0.96	Other	16	2
233	EPI.ileal_enterocyte_crypt.proliferative_S	1.59	Nonsignificant	0.95	0.41	Other	4	2
234	EPI.skin_interfollicular_spinous.inflammatory	1.58	Nonsignificant	—	0.00	Other	0	0
235	EPI.ileal_goblet.inflammatory_mucin	1.52	Nonsignificant	0.93	0.22	Other	6	9
236	T.CD8_naive.innate_like	1.51	Nonsignificant	0.99	0.72	Other	10	1
237	T.CD4_Treg.Tr1_like	1.51	Nonsignificant	—	0.25	Other	8	8
238	EPI.ileal_goblet.stress_metallothionein	1.48	Nonsignificant	—	0.00	Other	4	11
239	MESO.activated_stress	1.47	Nonsignificant	—	0.51	Other	0	0
240	B.age_associated.naive_transitional	1.45	Nonsignificant	—	0.63	Other	0	0
241	T.CD4_transitional.tissue_enagement	1.44	Nonsignificant	1.00	0.23	Other	5	11
242	T.CD8_naive.cytokine_dampened	1.41	Nonsignificant	1.00	0.50	Other	71	4
243	HPC.GMP_inflammatory	1.41	Nonsignificant	0.64	1.03	Other	20	10
244	EPI.ileal_enterocyte_absorptive.villus_tip	1.38	Nonsignificant	4.78e-05	2.61	Other	4	3
245	T.CD8_naive.splicing_enriched	1.38	Nonsignificant	1.00	0.35	Other	120	16
246	B.age_associated.activated	1.34	Nonsignificant	—	0.20	Other	18	22
247	HEP.pericentral_lipoprotein.UPR_redox	1.33	Nonsignificant	—	0.67	Other	0	0
248	SMC.contractile	1.32	Nonsignificant	0.38	1.11	Other	80	588
249	EPI.colonocyte.distal_absorptive	1.29	Nonsignificant	—	1.48	Other	0	0
250	ILC2.migratory	1.26	Nonsignificant	—	0.00	Other	0	0
251	MONO.CD16.patrolling	1.19	Nonsignificant	1.00	0.38	Other	797	216
252	MAC.kupffer.metabolic	1.19	Nonsignificant	—	1.05	Other	25	36
253	PC.IgG_systemic.metabolic	1.18	Nonsignificant	0.92	0.88	Other	46	63
254	PC.IgA_muocsal.migratory	1.15	Nonsignificant	0.20	1.33	Other	4	1
255	T.CD4_Th2.tissue_adapted	1.14	Nonsignificant	—	0.00	Other	0	0
256	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	1.14	Nonsignificant	—	0.00	Other	0	0
257	DC.cDC1.cross_presenting	1.13	Nonsignificant	—	0.00	Other	0	0
258	EPI.pancreatic_islet.delta	1.13	Nonsignificant	—	0.00	Other	0	0
259	FIB.hepatic_stellate_cell.contractile	1.10	Nonsignificant	—	1.15	Other	0	0
260	EPI.tracheal_submucosal_gland.acinar_serous	1.07	Nonsignificant	—	0.42	Other	0	0
261	HPC.CLP_B_primed	1.06	Nonsignificant	—	0.17	Other	0	0
262	HEP.pericentral_lipoprotein.ApoB_coagulation	1.06	Nonsignificant	—	0.00	Other	0	0
263	EPI.colonocyte.ionocyte_BEST4	1.06	Nonsignificant	0.78	1.23	Other	103	188
264	B.age_associated.migratory	1.05	Nonsignificant	0.91	0.28	Other	2	2
265	FIB.hepatic_stellate_cell.inflammatory	1.04	Nonsignificant	—	0.32	Other	0	0
266	EC.liver_sinusoidal.remodeling_lipotoxicity	1.00	Nonsignificant	—	0.97	Other	90	58
267	MESO.baseline	0.97	Nonsignificant	0.50	1.09	Other	0	6
268	DC.cDC1.activated	0.97	Nonsignificant	—	0.00	Other	0	0
269	PC.IgA_muocsal.baseline	0.95	Nonsignificant	0.84	0.88	Other	3	5
270	T.CD4_Treg.APC_interactive	0.93	Nonsignificant	1.00	0.08	Other	118	28
271	THYMO.SP_CD8_transitional	0.91	Nonsignificant	3.57e-04	2.10	Other	32	75
272	EPI.pancreatic_islet.beta	0.90	Nonsignificant	0.89	0.54	Other	42	57
273	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.90	Nonsignificant	—	0.00	Other	0	0
274	PC.IgA_muocsal.activated	0.89	Nonsignificant	0.84	0.79	Other	17	8
275	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.89	Nonsignificant	—	1.03	Other	39	82
276	THYMO.DP_early_stress	0.88	Nonsignificant	—	1.52	Other	0	0
277	EPI.tracheal_submucosal_gland.ductal_luminal	0.87	Nonsignificant	—	0.00	Other	0	0
278	T.CD4_naive.gut_prone	0.85	Nonsignificant	1.00	8.46e-03	Other	35	70
279	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.84	Nonsignificant	—	0.00	Other	0	0
280	EPI.ileal_enterocyte_absorptive.brush_border	0.82	Nonsignificant	0.99	0.16	Other	580	1,717
281	PC.IgA_muocsal.plasmablast	0.81	Nonsignificant	0.84	0.88	Other	5	4
282	FIB.hepatic_stellate_cell.fibrogenic	0.79	Nonsignificant	—	0.00	Other	0	0
283	GRANU.MAST.resting_granule	0.78	Nonsignificant	—	0.63	Other	0	0
284	ASTRO.homeostatic	0.77	Nonsignificant	0.12	1.27	Other	200	431
285	EPI.salivary_serous_acinar.secretory_active	0.77	Nonsignificant	1.82e-08	2.20	Other	242	69
286	MAC.kupffer.inflammatory	0.76	Nonsignificant	—	0.38	Other	7	4
287	EC.liver_sinusoidal.prostanoid	0.74	Nonsignificant	—	0.18	Other	11	64
288	ASTRO.stress_mito	0.72	Nonsignificant	0.73	1.11	Other	47	110
289	DC.mig.baseline	0.70	Nonsignificant	—	0.00	Other	1	0
290	DC.cDC2.tolerogenic_regulatory	0.69	Nonsignificant	1.00	0.63	Other	44	4
291	IPSC.stress	0.68	Nonsignificant	1.00	1.06	Other	0	0
292	ASTRO.immature_lipid	0.68	Nonsignificant	0.73	1.15	Other	23	113
293	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.65	Nonsignificant	0.03	1.77	Other	449	1,034
294	PC.IgG_systemic.interacting	0.65	Nonsignificant	0.92	0.47	Other	0	0
295	EPI.colonic_tuft.homeostatic	0.64	Nonsignificant	—	0.73	Other	0	0
296	EPI.esophageal_suprabasal.differentiating_keratin	0.64	Nonsignificant	0.17	1.60	Other	131	61
297	SCHWN.translation_boost	0.62	Nonsignificant	—	0.34	Other	8	1
298	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.62	Nonsignificant	—	0.76	Other	2	0
299	EPI.esophageal_suprabasal.proliferative_exit	0.61	Nonsignificant	—	0.00	Other	0	0
300	EPI.esophageal_suprabasal.basal_transitional	0.61	Nonsignificant	0.17	1.48	Other	44	67
301	MAC.microglia_like.phagocytic_redox	0.60	Nonsignificant	—	0.52	Other	0	0
302	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.60	Nonsignificant	—	0.28	Other	6	9
303	B.naive.activated	0.59	Nonsignificant	7.38e-03	1.38	Other	77	127
304	FIB.adventitial.inflammatory_activated	0.59	Nonsignificant	0.54	1.10	Other	100	473
305	ADIPO.hypoxia_remodelling	0.59	Nonsignificant	—	0.85	Other	29	105
306	DC.cDC2.lipid_metabolic	0.58	Nonsignificant	—	0.00	Other	0	0
307	EPI.gastric_foveolar.baseline	0.58	Nonsignificant	—	0.00	Other	0	0
308	THYMO.DP_early	0.58	Nonsignificant	1.20e-06	2.01	Other	326	313
309	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.56	Nonsignificant	—	0.10	Other	0	0
310	B.memory.activated	0.56	Nonsignificant	0.01	1.26	Other	105	29
311	MONO.CD14.platelet_bound	0.55	Nonsignificant	0.33	1.16	Other	964	176
312	GRANU.MAST.activated_repair	0.54	Nonsignificant	—	0.00	Other	0	1
313	EC.liver_sinusoidal.hypoxia_metabolic	0.52	Nonsignificant	0.98	0.65	Other	183	107
314	SMC.metabolic	0.52	Nonsignificant	0.71	0.93	Other	14	40
315	THYMO.proliferative_G2M	0.50	Nonsignificant	—	0.00	Other	164	413
316	SMC.activated	0.49	Nonsignificant	0.38	1.10	Other	2	5
317	EPI.colonic_enteroendocrine.Lcell_peptide	0.48	Nonsignificant	—	0.00	Other	0	0
318	SCHWN.reactive_inflammatory	0.48	Nonsignificant	—	0.00	Other	0	0
319	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.46	Nonsignificant	—	0.44	Other	5	3
320	EPI.esophageal_basal.junctional_barrier	0.46	Nonsignificant	—	0.32	Other	0	0
321	EPI.hepatic_ductular_cholangiocyte.polarity	0.46	Nonsignificant	—	0.49	Other	0	0
322	SCHWN.axon_contact_cardiac	0.45	Nonsignificant	0.61	0.85	Other	18	63
323	EPI.ectocervical_granular.proliferative_basal	0.44	Nonsignificant	—	1.15	Other	0	0
324	PLAT.adhesion	0.44	Nonsignificant	—	0.48	Other	0	0
325	DC.cDC1.proliferative	0.44	Nonsignificant	—	0.00	Other	0	0
326	FIB.adventitial.PI16_matrix	0.43	Nonsignificant	1.00	1.02	Other	70	90
327	EPI.skin_keratinocyte_basal.spinous_transition	0.43	Nonsignificant	—	0.97	Other	0	0
328	EPI.esophageal_suprabasal.proliferative_S	0.42	Nonsignificant	—	0.00	Other	26	41
329	EC.liver_sinusoidal.stress	0.41	Nonsignificant	—	0.00	Other	413	158
330	MONO.CD14.remodeling	0.41	Nonsignificant	0.33	1.05	Other	2,373	295
331	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.41	Nonsignificant	0.62	1.26	Other	14	32
332	EPI.colonocyte.secretory_boost	0.40	Nonsignificant	0.92	1.12	Other	98	91
333	EPI.colonic_tuft.activated	0.39	Nonsignificant	—	0.00	Other	0	0
334	MAC.kupffer.stress	0.39	Nonsignificant	0.91	0.41	Other	9	3
335	THYMO.SP_CD4_naive	0.39	Nonsignificant	0.60	1.12	Other	65	75
336	FIB.suburothelial.inflammatory_prostanoid	0.39	Nonsignificant	—	0.68	Other	0	0
337	FIB.suburothelial.contractile_myofibroblast	0.37	Nonsignificant	—	0.60	Other	9	0
338	DC.cDC2.pro_inflammatory	0.37	Nonsignificant	1.00	0.29	Other	3	5
339	THYMO.DN_preTCR	0.37	Nonsignificant	0.60	1.19	Other	41	71
340	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.37	Nonsignificant	—	0.00	Other	0	0
341	EPI.skin_hair_follicle_bulge.quiescent	0.36	Nonsignificant	9.48e-04	1.58	Other	56	69
342	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.36	Nonsignificant	—	1.15	Other	0	0
343	ASTRO.A2_reactive	0.35	Nonsignificant	1.00	0.93	Other	10	37
344	EPI.esophageal_basal.activated_progenitor	0.35	Nonsignificant	0.66	0.81	Other	1	0
345	GRANU.MAST.activated_acute	0.35	Nonsignificant	—	0.00	Other	0	0
346	THYMO.SP_CD8_naive_stress	0.35	Nonsignificant	0.92	0.72	Other	1	1
347	MAC.kupffer.fibrogenic	0.34	Nonsignificant	—	0.00	Other	0	0
348	FIB.suburothelial.homeostasis_matrix	0.32	Nonsignificant	0.72	1.19	Other	258	921
349	MAC.microglia_like.inflammatory_chemokine	0.31	Nonsignificant	—	0.34	Other	20	32
350	THYMO.CD8aa_IELp	0.31	Nonsignificant	—	0.00	Other	1	7
351	EPI.renal_distal_tubule.stress	0.30	Nonsignificant	—	0.00	Other	0	0
352	EPI.esophageal_suprabasal.proliferative_G2M	0.30	Nonsignificant	—	0.00	Other	0	0
353	MAC.MDM.inflammatory_phagocytic	0.29	Nonsignificant	0.40	1.18	Other	199	52
354	CM.contractile_oxphos	0.28	Nonsignificant	1.00	1.08	Other	6	19
355	EC.liver_sinusoidal.secretory_lipoprotein	0.27	Nonsignificant	0.98	0.18	Other	120	70
356	MESO.antiviral	0.27	Nonsignificant	—	0.00	Other	3	8
357	THYMO.SP_CD8_naive	0.27	Nonsignificant	1.00	0.48	Other	297	177
358	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.26	Nonsignificant	—	0.00	Other	0	0
359	B.naive.baseline	0.24	Nonsignificant	0.99	1.06	Other	10	13
360	EPI.skin_keratinocyte_progenitor.activated_stress	0.23	Nonsignificant	—	0.00	Other	0	0
361	ASTRO.synaptic_interaction	0.23	Nonsignificant	1.00	0.85	Other	76	334
362	MAC.MDM.APC_dendritic	0.23	Nonsignificant	0.51	1.14	Other	48	15
363	FIB.suburothelial.urothelial_interface	0.22	Nonsignificant	0.93	0.28	Other	9	8
364	FIB.skin_sheath.ECM_immune	0.21	Nonsignificant	—	0.35	Other	0	0
365	FIB.transitioning.ISG_primed_interface	0.21	Nonsignificant	—	0.37	Other	17	80
366	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.21	Nonsignificant	—	0.97	Other	0	0
367	EPI.skin_keratinocyte_basal.transit_amplifying	0.20	Nonsignificant	—	0.00	Other	0	0
368	FIB.perivascular_interface.vasomotor_tone	0.20	Nonsignificant	—	0.52	Other	0	0
369	FIB.skin_sheath.stress_chaperone	0.20	Nonsignificant	—	0.23	Other	0	0
370	FIB.perivascular_interface.vascular_BM_remodelling	0.20	Nonsignificant	—	0.41	Other	0	0
371	GRNLSA.proliferative_migratory	0.20	Nonsignificant	0.20	1.17	Other	248	292
372	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.20	Nonsignificant	—	0.00	Other	0	0
373	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.19	Nonsignificant	—	0.00	Other	0	0
374	EC.heart_remodeling.remodeling_secretory	0.18	Nonsignificant	0.07	1.33	Other	605	1,341
375	MONO.CD14.baseline	0.17	Nonsignificant	1.00	0.60	Other	2,268	76
376	THYMO.proliferative_S	0.17	Nonsignificant	0.66	1.02	Other	163	418
377	EC.heart_remodeling.activated_acute	0.17	Nonsignificant	0.92	1.05	Other	102	186
378	CM.mechano_activated	0.16	Nonsignificant	1.00	1.05	Other	205	134
379	ASTRO.hypoxia_angiogenic	0.16	Nonsignificant	1.00	0.88	Other	5	18
380	EPI.hepatic_ductular_cholangiocyte.stress	0.15	Nonsignificant	—	0.00	Other	0	0
381	HPC.MEP	0.15	Nonsignificant	1.00	0.11	Other	599	1,195
382	IPSC.canonical_pluripotent	0.15	Nonsignificant	0.09	1.07	Other	0	0
383	MUSC.baseline	0.15	Nonsignificant	0.06	1.76	Other	0	0
384	FIB.lung_alveolar.stress_interacting	0.15	Nonsignificant	—	0.97	Other	0	0
385	EPI.salivary_duct_excretory.stress	0.14	Nonsignificant	0.49	1.20	Other	33	68
386	EPI.skin_follicular_keratinizing.transit_amplifying	0.14	Nonsignificant	—	0.00	Other	21	49
387	EPI.cervical_suprabasal.secretory_vesicle	0.14	Nonsignificant	—	0.00	Other	0	0
388	FIB.reticular.immune_interface	0.14	Nonsignificant	—	0.42	Other	1	6
389	MEL.neurotrophic_migratory	0.13	Nonsignificant	—	1.27	Other	0	0
390	EC.arterial.angiogenic_tip	0.13	Nonsignificant	—	0.23	Other	30	37
391	DC.cDC2.proliferative	0.12	Nonsignificant	—	0.00	Other	39	71
392	EC.capillary.activated	0.12	Nonsignificant	0.69	1.09	Other	2	5
393	EPI.pancreatic_ductal_bicarbonate.baseline	0.12	Nonsignificant	0.62	1.10	Other	11	42
394	FIB.perivascular_interface.lipid_shuttle	0.12	Nonsignificant	—	0.00	Other	51	170
395	MEL.dedifferentiated_migratory	0.11	Nonsignificant	—	0.54	Other	0	0
396	EPI.skin_follicular_keratinizing.root_infundibulum	0.11	Nonsignificant	—	0.58	Other	0	0
397	EC.heart_remodeling.capillary_metabolic	0.10	Nonsignificant	0.62	1.21	Other	54	414
398	EC.arterial.homeostatic	0.10	Nonsignificant	0.78	1.01	Other	24	3
399	FIB.tracheal_subepithelial.baseline	0.10	Nonsignificant	—	0.00	Other	0	0
400	EC.venous.cardiac_structural	0.10	Nonsignificant	0.58	1.16	Other	102	229
401	MAC.kupffer.tolerogenic	0.10	Nonsignificant	—	0.00	Other	45	49
402	B.naive.restrained	0.10	Nonsignificant	0.99	0.97	Other	183	353
403	EPI.skin_follicular_keratinizing.upper_infundibulum	0.10	Nonsignificant	—	0.14	Other	8	2
404	PERI.cardiac_skeletal	0.10	Nonsignificant	1.81e-12	1.69	Other	313	630
405	MUSC.early_activation	0.09	Nonsignificant	1.00	1.00	Other	4	32
406	EPI.pancreatic_ductal_bicarbonate.activated	0.09	Nonsignificant	0.99	0.95	Other	10	7
407	MESO.secretory_structural	0.09	Nonsignificant	—	0.00	Other	0	0
408	EPI.pancreatic_acinar.inflammatory_regenerative	0.09	Nonsignificant	1.00	1.10	Other	25	113
409	EPI.cervical_suprabasal.inflammatory_repair	0.09	Nonsignificant	—	0.00	Other	0	0
410	B.naive.purinergic	0.09	Nonsignificant	0.99	0.92	Other	384	820
411	MUSC.quiescent_reservoir	0.09	Nonsignificant	1.00	0.73	Other	2	8
412	EPI.colonocyte.goblet_interface	0.09	Nonsignificant	—	0.49	Other	11	21
413	MONO.CD14.cord_tolerance	0.08	Nonsignificant	1.00	0.84	Other	864	753
414	FIB.transitioning.matrix_stress	0.08	Nonsignificant	—	0.19	Other	47	138
415	FIB.adventitial.adhesion_lipid	0.08	Nonsignificant	1.00	0.94	Other	58	209
416	EC.heart_remodeling.angiocrine	0.08	Nonsignificant	1.00	0.82	Other	182	525
417	EPI.salivary_serous_acinar.seromucous_like	0.08	Nonsignificant	—	0.00	Other	0	0
418	EC.arterial.arteriole_interface	0.08	Nonsignificant	0.76	1.06	Other	31	12
419	GRNLSA.angiocrine_mechanosensory	0.08	Nonsignificant	—	1.24	Other	0	0
420	EC.arterial.inflammatory	0.08	Nonsignificant	0.24	1.27	Other	63	50
421	FIB.skin_sheath.neuro_vascular_interface	0.07	Nonsignificant	—	0.00	Other	0	0
422	ADIPO.thermogenic	0.07	Nonsignificant	—	0.44	Other	0	0
423	FIB.adventitial.activated_remodelling	0.07	Nonsignificant	—	1.09	Other	141	319
424	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.07	Nonsignificant	0.65	1.19	Other	11	22
425	MAC.resident_iron.stress_tolerogenic	0.07	Nonsignificant	—	0.96	Other	0	0
426	FIB.barrier_purinergic.lipid_secretory	0.07	Nonsignificant	—	0.48	Other	0	0
427	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.07	Nonsignificant	—	0.73	Other	0	0
428	EC.capillary.inflammatory	0.07	Nonsignificant	0.69	1.04	Other	27	51
429	PC.IgG_systemic.stress	0.07	Nonsignificant	—	0.00	Other	1	5
430	B.naive.receptor_recycle	0.07	Nonsignificant	0.99	0.71	Other	51	0
431	MAC.resident_iron.APC_iron_sensing	0.07	Nonsignificant	0.57	0.99	Other	211	114
432	B.naive.metabolic	0.07	Nonsignificant	0.99	0.77	Other	50	79
433	B.memory.pDC_imprint	0.06	Nonsignificant	1.00	0.86	Other	157	103
434	B.naive.remodeling	0.06	Nonsignificant	0.99	0.80	Other	135	230
435	FIB.transitioning.secretory_procollagen	0.06	Nonsignificant	—	0.00	Other	0	0
436	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.06	Nonsignificant	—	0.00	Other	0	0
437	MAC.resident_iron.heme_catabolism	0.06	Nonsignificant	0.34	1.25	Other	30	51
438	EC.arterial.arteriole_gas_exchange	0.06	Nonsignificant	0.88	0.93	Other	238	131
439	EPI.colonocyte.crypt_progenitor	0.06	Nonsignificant	0.97	0.98	Other	115	265
440	EC.arterial.mito_contact	0.06	Nonsignificant	0.76	1.13	Other	14	5
441	MEL.secretory_quiescent	0.05	Nonsignificant	1.00	1.02	Other	19	13
442	MAC.MDM.LAM_like	0.05	Nonsignificant	1.00	0.78	Other	12	14
443	EPI.salivary_duct_excretory.baseline	0.05	Nonsignificant	0.96	0.44	Other	23	57
444	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.05	Nonsignificant	—	0.00	Other	0	0
445	FIB.skin_neurosecretory.baseline	0.05	Nonsignificant	—	0.00	Other	0	0
446	B.memory.preactivated	0.05	Nonsignificant	1.00	0.90	Other	173	174
447	GRANU.neutrophil.antiviral_endotoxin	0.05	Nonsignificant	—	0.64	Other	0	0
448	B.naive.proteostasis	0.05	Nonsignificant	0.99	0.78	Other	49	69
449	EPI.endocervical_secretory.secretory_translocon	0.05	Nonsignificant	—	0.00	Other	0	0
450	EPI.thymic_medullary.stress_APC	0.05	Nonsignificant	0.47	1.30	Other	2	4
451	MUSC.activated_migratory	0.04	Nonsignificant	1.00	7.00e-04	Other	6	7
452	EPI.thymic_medullary.hormone_xeno_barrier	0.04	Nonsignificant	—	0.00	Other	0	8
453	EC.heart_remodeling.remodeling_stalk	0.04	Nonsignificant	1.00	0.72	Other	33	111
454	IPSC.endoderm_primed	0.04	Nonsignificant	1.00	1.06	Other	0	0
455	EPI.colonocyte.proximal_transport	0.04	Nonsignificant	0.97	0.83	Other	24	12
456	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.04	Nonsignificant	0.30	1.31	Other	2	9
457	MAC.resident_iron.redox_metabolic	0.04	Nonsignificant	0.57	1.03	Other	4	4
458	MONO.CD14.repair_M2_like	0.04	Nonsignificant	1.00	0.51	Other	550	1,495
459	B.memory.baseline	0.04	Nonsignificant	1.00	0.64	Other	472	99
460	EPI.thymic_medullary.canonical_alarmin	0.04	Nonsignificant	0.47	0.98	Other	8	17
461	EC.arterial.ion_pump	0.04	Nonsignificant	0.88	0.82	Other	3	2
462	EPI.pancreatic_acinar.quiet_dedifferentiation	0.04	Nonsignificant	1.00	1.02	Other	142	171
463	EC.arterial.metabolic	0.04	Nonsignificant	0.24	1.25	Other	195	159
464	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.04	Nonsignificant	—	0.00	Other	0	0
465	EPI.thymic_medullary.proliferative_APC	0.04	Nonsignificant	—	0.00	Other	0	0
466	GRANU.neutrophil.tissue_patrolling	0.04	Nonsignificant	—	0.00	Other	0	0
467	MG.baseline	0.04	Nonsignificant	0.34	1.24	Other	16	5
468	GRANU.neutrophil.primed_degranulation	0.04	Nonsignificant	—	0.00	Other	0	0
469	EC.arterial.elastic	0.03	Nonsignificant	0.95	0.74	Other	22	45
470	EC.capillary.stress	0.03	Nonsignificant	0.69	1.03	Other	44	36
471	MONO.CD14.inflammatory	0.03	Nonsignificant	1.00	0.76	Other	92	134
472	FIB.lung_alveolar.mito_secretory	0.03	Nonsignificant	—	0.00	Other	0	0
473	MAC.resident_cardiac.inflammatory_reparative	0.03	Nonsignificant	0.75	1.02	Other	31	96
474	B.naive.antigen_presenting_ready	0.03	Nonsignificant	0.99	0.59	Other	48	73
475	EPI.renal_immature_ureteric_bud.defense_secretory	0.03	Nonsignificant	0.78	1.06	Other	45	76
476	ASTRO.A1_reactive	0.03	Nonsignificant	1.00	0.46	Other	433	394
477	EPI.renal_principal_cell.inflammatory	0.03	Nonsignificant	0.15	1.38	Other	74	157
478	EC.venous.adipose_lipid	0.03	Nonsignificant	7.90e-03	1.17	Other	254	476
479	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.03	Nonsignificant	—	0.00	Other	29	88
480	FIB.interstitial.mesenchymal_regulator	0.03	Nonsignificant	0.28	1.21	Other	4	4
481	EPI.ectocervical_granular.inflammatory	0.02	Nonsignificant	—	0.32	Other	0	0
482	EPI.skin_sebaceous_duct_luminal.detox_repair	0.02	Nonsignificant	0.76	0.84	Other	137	94
483	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.02	Nonsignificant	—	0.73	Other	0	0
484	EC.capillary.baseline	0.02	Nonsignificant	0.90	0.97	Other	246	560
485	EC.heart_remodeling.perivascular	0.02	Nonsignificant	1.00	0.37	Other	124	408
486	EPI.salivary_intercalated_defense.inflammatory	0.02	Nonsignificant	0.66	0.88	Other	152	360
487	PERI.angiocrine	0.02	Nonsignificant	1.00	0.62	Other	93	102
488	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.02	Nonsignificant	—	0.00	Other	0	0
489	PERI.inflammatory	0.02	Nonsignificant	0.62	1.06	Other	40	77
490	EPI.salivary_serous_acinar.quiescent	0.02	Nonsignificant	1.00	0.00	Other	178	493
491	EC.capillary.angiocrine	0.02	Nonsignificant	0.80	1.00	Other	250	630
492	MAC.resident_cardiac.phagocytic_homeostasis	0.02	Nonsignificant	0.94	0.79	Other	564	1,221
493	MG.phagocytic_APC	0.02	Nonsignificant	0.80	0.97	Other	25	8
494	EPI.renal_principal_cell.activated_acute	0.02	Nonsignificant	1.00	1.07	Other	29	59
495	CM.osmoprotection	0.02	Nonsignificant	1.00	1.02	Other	34	57
496	EPI.renal_immature_ureteric_bud.osmoprotective	0.02	Nonsignificant	0.78	0.86	Other	126	44
497	FIB.interstitial.immune_interact	0.02	Nonsignificant	0.28	1.15	Other	12	1
498	FIB.transitioning.motility_remodelling	0.02	Nonsignificant	—	0.00	Other	0	0
499	EC.capillary.angiogenic_tip	0.02	Nonsignificant	0.69	1.08	Other	186	218
500	MEL.stress_glucocorticoid	0.01	Nonsignificant	1.00	0.60	Other	11	34
501	FIB.reticular.stromal_niche	0.01	Nonsignificant	0.45	1.08	Other	0	0
502	FIB.reticular.stress_metallothionein	0.01	Nonsignificant	—	0.00	Other	3	32
503	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.01	Nonsignificant	—	0.00	Other	0	0
504	MAC.microglia_like.patrolling_adhesive	0.01	Nonsignificant	—	0.00	Other	0	0
505	EPI.pancreatic_acinar.stress	0.01	Nonsignificant	1.00	0.94	Other	28	28
506	FIB.skin_tenogenic.baseline	0.01	Nonsignificant	—	0.00	Other	0	2
507	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.01	Nonsignificant	7.70e-04	2.16	Other	58	89
508	OLG.stress	0.01	Nonsignificant	0.57	1.23	Other	232	8
509	PERI.baseline	0.01	Nonsignificant	1.00	0.27	Other	39	66
510	CHOND.angiogenic	0.01	Nonsignificant	—	1.37	Other	0	0
511	EC.capillary.migratory	0.01	Nonsignificant	0.90	0.94	Other	181	509
512	EC.heart_remodeling.translation_boost	0.01	Nonsignificant	—	0.00	Other	0	0
513	FIB.skin_papillary.baseline	0.01	Nonsignificant	—	0.00	Other	0	0
514	EPI.ectocervical_granular.immune_interact	0.01	Nonsignificant	—	0.00	Other	0	0
515	IPSC.mesenchymal_primed	0.01	Nonsignificant	1.00	0.94	Other	0	0
516	ASPC.inflammatory	0.01	Nonsignificant	0.65	1.15	Other	21	61
517	ASTRO.neuromodulatory	0.01	Nonsignificant	1.00	0.35	Other	34	172
518	CM.baseline	9.84e-03	Nonsignificant	1.00	0.94	Other	393	0
519	EPI.pancreatic_acinar.baseline	9.66e-03	Nonsignificant	1.00	1.00	Other	274	163
520	MAC.resident_repair.stress_iron	9.47e-03	Nonsignificant	0.38	1.27	Other	48	97
521	ASPC.stem_like_progenitor	9.36e-03	Nonsignificant	0.65	1.10	Other	300	842
522	MAC.LAM.inflammatory_APC	9.33e-03	Nonsignificant	0.43	1.07	Other	872	165
523	EPI.alveolar_type_1.activated	8.60e-03	Nonsignificant	—	1.64	Other	0	0
524	MG.expanding	8.55e-03	Nonsignificant	0.86	0.68	Other	2	1
525	EC.venous.baseline	8.51e-03	Nonsignificant	0.98	0.94	Other	346	807
526	ASPC.mesothelial_like	8.36e-03	Nonsignificant	0.65	1.25	Other	143	486
527	ASTRO.stress_acute	8.35e-03	Nonsignificant	1.00	0.37	Other	60	56
528	ASPC.activated	8.19e-03	Nonsignificant	0.83	1.03	Other	164	162
529	IPSC.neuroendocrine_primed	8.00e-03	Nonsignificant	—	1.09	Other	0	0
530	EC.capillary.postcap_venule	7.77e-03	Nonsignificant	0.91	0.91	Other	355	261
531	EC.lymphatic.valve	7.69e-03	Nonsignificant	—	2.18	Other	0	0
532	MAC.LAM.anti_inflammatory	7.34e-03	Nonsignificant	0.74	1.05	Other	86	132
533	MAC.LAM.lipid_opsonization	7.27e-03	Nonsignificant	0.68	1.13	Other	45	14
534	FIB.neurolectin_mucosa.remodeling_repair	7.08e-03	Nonsignificant	—	0.32	Other	4	2
535	FIB.reticular.ECM_builder	6.90e-03	Nonsignificant	—	0.00	Other	0	0
536	MAC.resident_repair.antigen_presenting	6.54e-03	Nonsignificant	0.77	1.06	Other	244	113
537	EPI.bile_duct_cholangiocyte.secretory_mucin	6.09e-03	Nonsignificant	—	0.00	Other	7	12
538	EPI.ectocervical_granular.secretory_apocrine	5.96e-03	Nonsignificant	—	0.00	Other	0	0
539	MAC.MDM.complement_resolving	5.88e-03	Nonsignificant	1.00	0.16	Other	440	860
540	EPI.skin_keratinocyte_basal.basement_anchoring	5.77e-03	Nonsignificant	—	0.00	Other	0	0
541	B.memory.migratory	5.73e-03	Nonsignificant	1.00	0.36	Other	123	208
542	EPI.pancreatic_ductal_bicarbonate.stress	5.63e-03	Nonsignificant	—	0.00	Other	12	33
543	EC.venous.activated	5.58e-03	Nonsignificant	0.98	0.97	Other	247	752
544	ASPC.proliferative	5.54e-03	Nonsignificant	0.83	1.10	Other	33	85
545	EPI.salivary_duct_ion_transport.baseline	5.48e-03	Nonsignificant	—	—	Other	0	0
546	MEL.mature_oxidative_traffic	5.17e-03	Nonsignificant	1.00	0.00	Other	247	285
547	EPI.renal_proximal_tubule.detox_antioxidant	5.06e-03	Nonsignificant	1.00	0.00	Other	394	77
548	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	4.57e-03	Nonsignificant	—	0.00	Other	0	0
549	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	4.53e-03	Nonsignificant	0.99	0.41	Other	40	191
550	FIB.interstitial.stress_secretory	4.51e-03	Nonsignificant	0.28	1.27	Other	92	56
551	FIB.neurolectin_mucosa.nerve_interface	4.35e-03	Nonsignificant	—	0.22	Other	4	0
552	GRNLSA.chemokine_mechanosensory	4.18e-03	Nonsignificant	0.98	0.88	Other	1	0
553	CHOND.activated_fibro_like	4.18e-03	Nonsignificant	0.67	1.08	Other	531	188
554	EPI.renal_principal_cell.canonical_vasopressin	4.17e-03	Nonsignificant	1.00	0.78	Other	2	0
555	ASPC.remodeling	3.97e-03	Nonsignificant	0.83	0.98	Other	106	354
556	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	3.88e-03	Nonsignificant	0.99	0.40	Other	219	533
557	MAC.resident_repair.lipid_phagocytic	3.72e-03	Nonsignificant	0.38	1.26	Other	228	604
558	FIB.neurolectin_mucosa.axon_responsive	3.60e-03	Nonsignificant	0.80	1.14	Other	10	10
559	EPI.colonocyte.junction_remodeling	3.53e-03	Nonsignificant	0.97	0.67	Other	218	305
560	ASPC.preadipocyte_lipid_primed	3.42e-03	Nonsignificant	0.83	0.95	Other	331	129
561	GRNLSA.secretory_remodeling	3.33e-03	Nonsignificant	0.98	0.89	Other	90	25
562	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	3.32e-03	Nonsignificant	—	0.00	Other	49	237
563	CHOND.pro_inflammatory	3.28e-03	Nonsignificant	0.69	1.03	Other	181	351
564	EC.venous.quiescent_homeostatic	3.24e-03	Nonsignificant	0.98	0.97	Other	456	360
565	GRNLSA.EMT_insulin_signaling	3.05e-03	Nonsignificant	0.98	1.01	Other	47	84
566	ASPC.baseline	2.98e-03	Nonsignificant	0.83	0.97	Other	363	170
567	ASPC.niche_keeping_progenitor	2.74e-03	Nonsignificant	0.83	0.94	Other	52	219
568	EPI.renal_thick_ascending_limb.barrier_repair	2.67e-03	Nonsignificant	0.01	1.26	Other	141	284
569	ASPC.adipocyte_capillary_interface	2.37e-03	Nonsignificant	0.83	0.96	Other	21	54
570	EPI.skin_hair_follicle_companion.activated_migratory	2.36e-03	Nonsignificant	—	0.00	Other	0	0
571	IPSC.midbrain_primed	2.23e-03	Nonsignificant	1.00	0.89	Other	0	0
572	CM.mito_proteostasis	2.18e-03	Nonsignificant	1.00	0.94	Other	329	29
573	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	2.15e-03	Nonsignificant	0.92	0.95	Other	7	16
574	EPI.salivary_myoepithelial.contractile_repair	2.03e-03	Nonsignificant	—	0.03	Other	3	9
575	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.00e-03	Nonsignificant	—	0.46	Other	105	368
576	FIB.neurolectin_mucosa.inflammatory	1.97e-03	Nonsignificant	0.85	0.60	Other	52	110
577	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.82e-03	Nonsignificant	—	0.60	Other	43	26
578	IPSC.mesendo_primed	1.79e-03	Nonsignificant	1.00	0.90	Other	0	0
579	EC.lymphatic.tip_migratory	1.76e-03	Nonsignificant	0.73	1.14	Other	23	37
580	CM.translation_boost_RPS	1.75e-03	Nonsignificant	1.00	0.94	Other	69	16
581	EPI.renal_distal_tubule.repair	1.75e-03	Nonsignificant	—	0.00	Other	34	102
582	EPI.skin_hair_follicle_bulge.anagen_growth	1.71e-03	Nonsignificant	—	0.00	Other	0	0
583	FIB.interstitial.remodeling	1.69e-03	Nonsignificant	0.94	0.85	Other	31	9
584	ASPC.secretory	1.63e-03	Nonsignificant	0.92	0.90	Other	76	5
585	IPSC.mesodermal_primed	1.55e-03	Nonsignificant	1.00	0.92	Other	0	0
586	EPI.pancreatic_ductal_perivascular.protective_antioxidant	1.51e-03	Nonsignificant	—	0.00	Other	11	69
587	EC.lymphatic.baseline	1.50e-03	Nonsignificant	0.73	1.20	Other	38	72
588	EPI.pancreatic_ductal_perivascular.baseline	1.46e-03	Nonsignificant	0.57	0.92	Other	1	5
589	OLG.myelinating_mature	1.45e-03	Nonsignificant	0.75	1.12	Other	363	94
590	EC.lymphatic.activated	1.41e-03	Nonsignificant	0.88	0.71	Other	47	73
591	EPI.renal_principal_cell.injury_repair	1.39e-03	Nonsignificant	1.00	0.40	Other	26	9
592	SKM.type_1_slow.glycolytic	1.38e-03	Nonsignificant	8.82e-03	1.25	Other	362	647
593	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.27e-03	Nonsignificant	—	0.76	Other	0	0
594	CHOND.remodeling	1.23e-03	Nonsignificant	—	0.45	Other	5	0
595	FIB.interstitial.lipid_matrix	1.18e-03	Nonsignificant	0.94	0.98	Other	258	191
596	FIB.barrier_secretory.homeostasis	1.18e-03	Nonsignificant	—	0.00	Other	0	0
597	IPSC.stromal_primed	1.09e-03	Nonsignificant	1.00	0.95	Other	0	0
598	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.06e-03	Nonsignificant	—	0.92	Other	0	0
599	EPI.salivary_mucous_acinar.baseline	1.05e-03	Nonsignificant	—	—	Other	394	683
600	EC.lymphatic.scavenger	1.03e-03	Nonsignificant	0.88	0.60	Other	203	257
601	GRNLSA.stress_metabolic	9.76e-04	Nonsignificant	—	0.11	Other	1	2
602	CM.oxidative_phospho	9.66e-04	Nonsignificant	1.00	0.93	Other	266	792
603	FIB.adventitial.mechano_chemo_sensing	9.65e-04	Nonsignificant	1.00	0.48	Other	135	524
604	PLAT.megakaryocytic	9.24e-04	Nonsignificant	—	0.00	Other	0	0
605	EPI.salivary_myoepithelial.baseline	8.70e-04	Nonsignificant	0.75	1.02	Other	42	141
606	MAC.resident_repair.chemokine_angiocrine	8.55e-04	Nonsignificant	0.99	0.95	Other	87	138
607	EPI.renal_thick_ascending_limb.remodeling	7.98e-04	Nonsignificant	0.13	1.16	Other	152	92
608	FIB.adventitial.complement_angiocrine	7.92e-04	Nonsignificant	1.00	0.45	Other	153	684
609	EPI.renal_intercalated_cell_type_B.baseline	7.70e-04	Nonsignificant	—	0.00	Other	3	1
610	MAC.proliferating.DNA_replication	7.46e-04	Nonsignificant	0.65	1.13	Other	3	6
611	EPI.salivary_intercalated_defense.basal_EMT	7.32e-04	Nonsignificant	—	0.00	Other	0	0
612	EPI.pancreatic_ductal_progenitor.baseline	7.09e-04	Nonsignificant	0.71	0.95	Other	179	702
613	EPI.salivary_myoepithelial.junctional_transport	5.78e-04	Nonsignificant	0.50	1.20	Other	66	121
614	FIB.barrier_secretory.remodeling	5.24e-04	Nonsignificant	—	0.00	Other	0	0
615	FIB.interstitial.mesenchymal_APC	4.89e-04	Nonsignificant	0.94	0.76	Other	81	33
616	EPI.renal_thick_ascending_limb.canonical_salt_transporter	4.87e-04	Nonsignificant	1.00	0.89	Other	322	317
617	EPI.renal_thick_ascending_limb.salt_sensing	4.63e-04	Nonsignificant	1.00	0.97	Other	73	103
618	EPI.skin_sweat_duct_keratinocyte.repair	4.21e-04	Nonsignificant	—	0.29	Other	0	0
619	EPI.alveolar_type_1.baseline	3.80e-04	Nonsignificant	1.00	0.00	Other	8	0
620	FIB.adventitial.baseline	3.73e-04	Nonsignificant	1.00	0.33	Other	157	278
621	FIB.adventitial.mito_secretory	3.40e-04	Nonsignificant	1.00	0.44	Other	21	7
622	SKM.type_2_fast.oxidative_IIa	3.39e-04	Nonsignificant	0.05	1.13	Other	946	56
623	CHOND.articular_collagen	3.31e-04	Nonsignificant	1.00	0.47	Other	551	266
624	CM.sarcomere_actin_interface	3.29e-04	Nonsignificant	1.00	0.85	Other	450	78
625	EPI.salivary_myoepithelial.activated	3.03e-04	Nonsignificant	0.88	0.80	Other	85	281
626	ADIPO.inflammatory	2.73e-04	Nonsignificant	—	0.00	Other	0	0
627	IPSC.neural_primed	2.68e-04	Nonsignificant	1.00	0.88	Other	0	0
628	SKM.type_2_fast.glycolytic_IIx_IIb	2.58e-04	Nonsignificant	0.10	1.12	Other	565	1,482
629	MAC.LAM.lipid_phagocytosis	2.20e-04	Nonsignificant	1.00	0.77	Other	369	328
630	EPI.renal_intercalated_cell_type_A.acid_secretion	2.13e-04	Nonsignificant	2.35e-04	1.58	Other	12	6
631	EPI.lung_multiciliated.mature_motile_cilia	2.07e-04	Nonsignificant	—	0.89	Other	0	0
632	IPSC.axial_identity_primed	2.03e-04	Nonsignificant	1.00	0.77	Other	0	0
633	MAC.LAM.perivascular_angiocrine	2.00e-04	Nonsignificant	—	0.10	Other	53	138
634	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	1.83e-04	Nonsignificant	—	0.00	Other	0	0
635	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.81e-04	Nonsignificant	0.92	0.59	Other	33	34
636	EPI.thymic_cortical.secretory_remodeling	1.60e-04	Nonsignificant	—	1.23	Other	4	1
637	MAC.LAM.antimicrobial	1.21e-04	Nonsignificant	1.00	0.61	Other	389	93
638	EPI.skin_sweat_duct_keratinocyte.barrier	1.16e-04	Nonsignificant	—	0.00	Other	0	0
639	CM.translation_boost_RPL	9.59e-05	Nonsignificant	1.00	0.80	Other	129	1
640	EPI.lung_multiciliated.stress	8.92e-05	Nonsignificant	—	0.00	Other	67	165
641	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	8.46e-05	Nonsignificant	—	0.00	Other	0	0
642	FIB.barrier_purinergic.stress_GF_binding	8.42e-05	Nonsignificant	—	0.00	Other	0	0
643	EPI.skin_appendage_keratinocyte.transit_amplifying	7.50e-05	Nonsignificant	—	0.00	Other	109	358
644	OLG.regulatory_activated	7.29e-05	Nonsignificant	0.57	1.12	Other	196	614
645	MAC.alveolar.capillary_interacting	6.62e-05	Nonsignificant	0.58	1.23	Other	113	181
646	CM.anti_inflammatory	6.51e-05	Nonsignificant	1.00	0.76	Other	424	1,503
647	EPI.renal_principal_cell.intercalated_like	6.41e-05	Nonsignificant	1.00	0.00	Other	63	66
648	MAC.alveolar.stress_metabolic	5.47e-05	Nonsignificant	0.67	1.13	Other	116	148
649	B.germinal_center.LZ_selection	5.36e-05	Nonsignificant	—	0.92	Other	0	0
650	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	4.72e-05	Nonsignificant	—	0.38	Other	0	0
651	EPI.skin_sebaceous_duct_luminal.immune_interface	4.63e-05	Nonsignificant	—	0.00	Other	0	0
652	GRNLSA.lipid_hypoxia	4.10e-05	Nonsignificant	0.98	0.63	Other	28	0
653	MAC.resident_iron.heme_recycling	3.97e-05	Nonsignificant	—	0.00	Other	30	37
654	OLG.regulatory	3.77e-05	Nonsignificant	0.85	0.87	Other	353	73
655	B.germinal_center.LZ_memory_precursor	3.63e-05	Nonsignificant	—	0.79	Other	0	0
656	EPI.pancreatic_ductal_progenitor.ADM_like	3.50e-05	Nonsignificant	—	0.23	Other	0	0
657	OLG.myelinating_stress	3.39e-05	Nonsignificant	0.75	0.97	Other	232	62
658	EPI.renal_thick_ascending_limb.cation_flux	3.30e-05	Nonsignificant	1.00	0.34	Other	57	95
659	EC.venous.remodeling_stalk	3.18e-05	Nonsignificant	0.98	0.64	Other	559	566
660	SKM.type_1_slow.contractile	2.39e-05	Nonsignificant	1.00	0.71	Other	596	8
661	GRNLSA.cholesterol_mevalonate	2.31e-05	Nonsignificant	0.98	0.67	Other	9	4
662	ADIPO.immature	2.21e-05	Nonsignificant	—	0.00	Other	24	40
663	OLG.vesicle_trafficking	1.98e-05	Nonsignificant	0.57	1.17	Other	124	10
664	EPI.lung_multiciliated.baseline	1.98e-05	Nonsignificant	—	0.00	Other	0	7
665	MAC.resident_repair.ECM_stromal_crosstalk	1.88e-05	Nonsignificant	0.99	0.62	Other	95	158
666	B.germinal_center.DZ_S_phase	1.20e-05	Nonsignificant	—	0.00	Other	0	0
667	MAC.alveolar.biosynthetic_sterol_heme	9.31e-06	Nonsignificant	0.71	1.06	Other	347	40
668	B.germinal_center.DZ_M_phase	7.76e-06	Nonsignificant	—	0.00	Other	0	0
669	EPI.pancreatic_acinar.metabolic_onecarbon	7.50e-06	Nonsignificant	1.00	0.29	Other	287	328
670	EPI.lung_club_secretory.ciliogenesis_axoneme	7.18e-06	Nonsignificant	—	0.00	Other	0	0
671	SKM.type_1_slow.oxidative	5.91e-06	Nonsignificant	1.00	0.26	Other	802	251
672	EPI.renal_distal_tubule.ciliated_remodelling	5.27e-06	Nonsignificant	—	0.00	Other	0	0
673	EPI.renal_distal_tubule.ion_transport	4.79e-06	Nonsignificant	—	0.00	Other	0	0
674	OLG.reactive_repair	3.86e-06	Nonsignificant	1.00	0.45	Other	385	385
675	EPI.pancreatic_acinar.adhesion_remodeling	3.40e-06	Nonsignificant	1.00	0.22	Other	210	784
676	EPI.renal_intercalated_cell_type_A.PC_transitional	3.10e-06	Nonsignificant	—	0.00	Other	203	407
677	MAC.proliferating.stress	2.02e-06	Nonsignificant	—	0.00	Other	87	136
678	IPSC.proliferative	1.38e-06	Nonsignificant	1.00	0.57	Other	0	0
679	EPI.thymic_cortical.Notch_interface	5.59e-07	Nonsignificant	—	0.00	Other	82	137
680	GRNLSA.p53_damage	4.80e-07	Nonsignificant	—	0.00	Other	13	10
681	EPI.thymic_cortical.baseline	3.21e-07	Nonsignificant	0.98	0.11	Other	185	386
682	B.germinal_center.LZ_survival	2.41e-07	Nonsignificant	—	0.00	Other	0	0
683	MAC.alveolar.lipid_autophagy	2.01e-07	Nonsignificant	—	0.20	Other	35	44
684	MAC.alveolar.inflammatory	8.22e-08	Nonsignificant	0.96	0.61	Other	208	312
685	EPI.skin_sweat_duct_keratinocyte.proliferative_S	3.67e-08	Nonsignificant	—	0.00	Other	0	0
686	MAC.alveolar.scavenging_endocytic	2.63e-09	Nonsignificant	—	0.00	Other	140	283
687	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	1.40e-09	Nonsignificant	—	0.00	Other	0	0
688	EPI.skin_keratinocyte_proliferating.detox_repair	1.22e-09	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

17 unique genes. Showing 1–17. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
ENSG00000305871	02-Medium	0.54	8.70	G2	C2	—	—	—	43	111
RGS12	02-Medium	0.52	6.57	G1	C2	—	T.CD8_Tem.early_helper_like (Tier: relevant)	30 cells — complete matches	55	131
MSANTD1	02-Medium	0.52	6.41	G1	C2	—	—	—	40	86
ENSG00000280087	02-Medium	0.51	3.47	G1	C2	—	—	—	359	1,576
TOMM40	02-Medium	0.48	4.31	G1	C2	—	—	DC.cDC2.monocyte_like (L2), EPI.ileal_goblet.immature (L2)	296	1,418
ENSG00000296398	02-Medium	0.47	6.58	G1	C2	—	—	—	47	117
APOC1	02-Medium	0.43	4.83	G1	C2	ASPC.adipocyte_capillary_interface (L2), ASPC.remodeling (L2), DC.cDC2.lipid_metabolic (L2), EPI.ectocervical_granular.secretory_apocrine (L2), FIB.reticular.stromal_niche (L2), MAC.MDM.LAM_like (L2), MONO.CD16.hepatic_mac_like (L2)	HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	135 cells — complete matches	301	1,434
HTT	02-Medium	0.42	4.89	G1	C2	—	T.CD8_Tcm.effector_bias (Tier: specific) T.CD8_Tem.TEMRA (Tier: relevant)	5 cells — complete matches	41	80
HGFAC	02-Medium	0.42	5.36	G1	C2	—	hepatocyte (Tier: specific) HEP.acute_phase (Tier: specific) HEP.canalicular_transport (Tier: specific) HEP.acute_phase.complement_metabolic (Tier: specific) HEP.acute_phase.hypoxia_lipid (Tier: relevant) HEP.acute_phase.inflammatory (Tier: relevant) HEP.acute_phase.proliferative (Tier: relevant) HEP.canalicular_transport.baseline (Tier: relevant) HEP.canalicular_transport.sterol_lipid_biosynthesis (Tier: relevant) HEP.periportal_metabolic.stress_checkpoint (Tier: relevant)	21 cells — complete matches	125	653
APOE	02-Medium	0.41	3.06	G1	C2	macrophage (L1), HEP.pericentral_lipoprotein (L1S), MAC.LAM (L1S), MAC.microglia_like (L1S), ASPC.adipocyte_capillary_interface (L2), EPI.ectocervical_granular.secretory_apocrine (L2), EPI.renal_intercalated_cell_type_A.acid_secretion (L2), EPI.skin_appendage_keratinocyte.sebaceous_apocrine (L2), EPI.skin_hair_follicle_bulge.niche_crosstalk (L2), EPI.skin_keratinocyte_progenitor.quiescent_stem_like (L2), EPI.skin_keratinocyte_proliferating.early_spinous_transition (L2), FIB.interstitial.lipid_matrix (L2), FIB.perivascular_interface.lipid_shuttle (L2), FIB.suburothelial.homeostasis_matrix (L2), FIB.transitioning.ISG_primed_interface (L2), HEP.acute_phase.stress_secretory (L2), HEP.periportal_metabolic.apolipoprotein_secretory (L2), MAC.LAM.inflammatory_APC (L2), MAC.MDM.LAM_like (L2), MAC.resident_repair.lipid_phagocytic (L2), MG.phagocytic_APC (L2), NEU.INH_LAMP5.glial_interface (L2)	EPI.skin_interfollicular_spinous.baseline (Tier: relevant) EPI.skin_interfollicular_spinous.early_differentiation (Tier: relevant) EPI.skin_interfollicular_spinous.stress_UPR (Tier: relevant) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant)	163 cells — complete matches	351	1,543
APOC1P1.2	02-Medium	0.39	3.43	G1	C2	—	—	—	317	1,464
APOC1P1	02-Medium	0.39	3.43	G1	C2	—	—	—	317	1,464
ENSG00000286900	02-Medium	0.37	4.53	G1	C2	—	—	—	38	113
DOK7	02-Medium	0.36	4.19	G1	C2	—	—	17 cells — complete matches	39	112
ENSG00000267282	02-Medium	0.35	2.56	G2	C2	—	—	—	213	1,188
APOC4-APOC2	02-Medium	0.34	3.90	G2	C2	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	10 cells — complete matches	211	1,246
APOC4	02-Medium	0.34	3.89	G2	C2	—	hepatocyte (Tier: specific) HEP.periportal_metabolic (Tier: specific) HEP.periportal_metabolic.urea_onecarbon_secretory (Tier: specific) HEP.periportal_metabolic.apolipoprotein_secretory (Tier: relevant) HEP.periportal_metabolic.inflammatory_activated (Tier: relevant)	10 cells — complete matches	242	1,341

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.